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4. Autopsy as on Outcome and Performance Measure: Three Years of Hospital Autopsy as an Instrument of Clinical Audit

Author

D’Errico, S., Martelloni, M., Niballi, S., Bonuccelli, D., Kacprzyk, Janusz, Series Editor, Pal, Nikhil R., Advisory Editor, Bello Perez, Rafael, Advisory Editor, Corchado, Emilio S., Advisory Editor, Hagras, Hani, Advisory Editor, Kóczy, László T., Advisory Editor, Kreinovich, Vladik, Advisory Editor, Lin, Chin-Teng, Advisory Editor, Lu, Jie, Advisory Editor, Melin, Patricia, Advisory Editor, Nedjah, Nadia, Advisory Editor, Nguyen, Ngoc Thanh, Advisory Editor, Wang, Jun, Advisory Editor, Bagnara, Sebastiano, editor, Tartaglia, Riccardo, editor, Albolino, Sara, editor, Alexander, Thomas, editor, and Fujita, Yushi, editor

Published
2019
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5. Hospital Autopsy for Prevention of Sudden Cardiac Death

Author

D’Errico, S., Martelloni, M., Niballi, S., Bonuccelli, D., Kacprzyk, Janusz, Series Editor, Pal, Nikhil R., Advisory Editor, Bello Perez, Rafael, Advisory Editor, Corchado, Emilio S., Advisory Editor, Hagras, Hani, Advisory Editor, Kóczy, László T., Advisory Editor, Kreinovich, Vladik, Advisory Editor, Lin, Chin-Teng, Advisory Editor, Lu, Jie, Advisory Editor, Melin, Patricia, Advisory Editor, Nedjah, Nadia, Advisory Editor, Nguyen, Ngoc Thanh, Advisory Editor, Wang, Jun, Advisory Editor, Bagnara, Sebastiano, editor, Tartaglia, Riccardo, editor, Albolino, Sara, editor, Alexander, Thomas, editor, and Fujita, Yushi, editor

Published
2019
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18. The weekend effect on the provision of Emergency Surgery before and during the COVID-19 pandemic: case-control analysis of a retrospective multicentre database

Author

Tebala G. D., Milani M. S., Cirocchi R., Bignell M., Bond-Smith G., Lewis C., Agnoletti V., Catarci M., Di Saverio S., Luridiana G., Catena F., Scatizzi M., Marini P., Lo Dico R., Stracqualursi A., Russo G., D'Errico S., Cianci P., Restini E., Scialandrone G., Guercioni G., Martinez G., Pezzolla A., Altomare D. F., Picciariello A., Trigiante G., Dibra R., Papagni V., Righetti C., Polastri R., Andreuccetti J., Pignata G., D'Alessio R., Arici E., Canfora I., Cillara N., Deserra A., Sechi R., Bianco F., Gili S., Cappiello A., Incollingo P., Biloslavo A., Bellio G., Germani P., De Manzini N., Buiatti M., Paladino F. P., Sasia D., Borghi F., Testa V., Giraudo G., Allisiardi F., Giuffrida M. C., Gerosa M., Fogliati A., Maggioni D., Fabbri N., Feo C. V., Bianchini E., Panzini I., Lizzi V., Tricarico F. G., Di Gioia G., Melino R., Tartaglia N., Ambrosi A., Pavone G., Pacilli M., Vovola F., Belli F., Barberis A., Azzinnaro A., Coratti A., Benigni R., Berti S., Saracco M., Gennai A., Dova L., Farfaglia R., Pata G., Arizzi V., Pandolfo G., Frontali A., Danelli P., Ferrario L., Guerci C., Mariani N. M., Pisani Ceretti A., Nicastro V., Opocher E., Gozzo D., Casoni Pattacini G., Castriconi M., Amendola A., Gaudiello M., Palomba G., Petracca G. L., Perrone G., Giuffrida M., Moretto G., Impellizzeri H., Casaril A., Filosa M., Caizzone A., Agrusti S., Cattaneo G. M., Capelli P., Muratore A., Calabro M., Pipitore Federico N., Cuzzola B., Danna R., Murgese A., Coccolini F., Pieroni E., Chiarugi M., Tartaglia D., Giannessi S., Somigli R., Trafeli M., Fedi M., De Vincenti R., Guariniello A., Grande M., Bagaglini G., Pirozzi B., Guida A. M., Ingallinella S., Don C. P., Siragusa L., Capone O., Cerbo D., Santoro E., Pende V., Fassari A., Mingoli A., Brachini G., Cirillo B., Zambon M., Cicerchia P., Meneghini S., Sapienza P., Puzzovio A., La Torre F., Fransvea P., Di Grezia M., Sganga G., Armellino M. F., Ioia G., Rampone B., Della Corte M., Fleres F., Clarizia G., Bordoni P., Spolini A., Franzini M., Grechi A., Suppo M., Bono D., Scaglione D., Cotsoglou C., Paleini S., Chierici A. P., Uccelli M., Olmi S., Cesana G., Tenreiro N., Marcal A., Martins D., Leal C., Vieira B., Ugarte-Sierra B., Vincene-Rodriguez I., Duran-Ballesteros M., Sanz-Larrainzar A., Ibanez-Aguirre F. J., Yanez-Benites C., Talal I., Blas J. L., Garau R., Clark-Stuart S., Wallace A., Di Carlo A., Wisnia E., Ehsan K., Beck-Sanders K., Godson E., Campbell P., Ahmad R., Ali R., Aswani S. S., Barza A., Carrillo C., Dawani A., Dey A., Elserafy A., Gaspar D., Lazzareschi L., Patel M., Shabana A., Shams M., Shams O., Slack Z., Tebala, Giovanni D, Milani, Marika S, Cirocchi, Roberto, Bignell, Mark, Bond-Smith, Gile, Lewis, Christopher, Agnoletti, Vanni, Catarci, Marco, Di Saverio, Salomone, Luridiana, Gianluigi, Catena, Fausto, Scatizzi, Marco, Marini, Pierluigi, de Manzini, Nicolo', Tebala G.D., Milani M.S., Cirocchi R., Bignell M., Bond-Smith G., Lewis C., Agnoletti V., Catarci M., Di Saverio S., Luridiana G., Catena F., Scatizzi M., Marini P., Lo Dico R., Stracqualursi A., Russo G., D'Errico S., Cianci P., Restini E., Scialandrone G., Guercioni G., Martinez G., Pezzolla A., Altomare D.F., Picciariello A., Trigiante G., Dibra R., Papagni V., Righetti C., Polastri R., Andreuccetti J., Pignata G., D'Alessio R., Arici E., Canfora I., Cillara N., Deserra A., Sechi R., Bianco F., Gili S., Cappiello A., Incollingo P., Biloslavo A., Bellio G., Germani P., De Manzini N., Buiatti M., Paladino F.P., Sasia D., Borghi F., Testa V., Giraudo G., Allisiardi F., Giuffrida M.C., Gerosa M., Fogliati A., Maggioni D., Fabbri N., Feo C.V., Bianchini E., Panzini I., Lizzi V., Tricarico F.G., Di Gioia G., Melino R., Tartaglia N., Ambrosi A., Pavone G., Pacilli M., Vovola F., Belli F., Barberis A., Azzinnaro A., Coratti A., Benigni R., Berti S., Saracco M., Gennai A., Dova L., Farfaglia R., Pata G., Arizzi V., Pandolfo G., Frontali A., Danelli P., Ferrario L., Guerci C., Mariani N.M., Pisani Ceretti A., Nicastro V., Opocher E., Gozzo D., Casoni Pattacini G., Castriconi M., Amendola A., Gaudiello M., Palomba G., Petracca G.L., Perrone G., Giuffrida M., Moretto G., Impellizzeri H., Casaril A., Filosa M., Caizzone A., Agrusti S., Cattaneo G.M., Capelli P., Muratore A., Calabro M., Pipitore Federico N., Cuzzola B., Danna R., Murgese A., Coccolini F., Pieroni E., Chiarugi M., Tartaglia D., Giannessi S., Somigli R., Trafeli M., Fedi M., De Vincenti R., Guariniello A., Grande M., Bagaglini G., Pirozzi B., Guida A.M., Ingallinella S., Don C.P., Siragusa L., Capone O., Cerbo D., Santoro E., Pende V., Fassari A., Mingoli A., Brachini G., Cirillo B., Zambon M., Cicerchia P., Meneghini S., Sapienza P., Puzzovio A., La Torre F., Fransvea P., Di Grezia M., Sganga G., Armellino M.F., Ioia G., Rampone B., Della Corte M., Fleres F., Clarizia G., Bordoni P., Spolini A., Franzini M., Grechi A., Suppo M., Bono D., Scaglione D., Cotsoglou C., Paleini S., Chierici A.P., Uccelli M., Olmi S., Cesana G., Tenreiro N., Marcal A., Martins D., Leal C., Vieira B., Ugarte-Sierra B., Vincene-Rodriguez I., Duran-Ballesteros M., Sanz-Larrainzar A., Ibanez-Aguirre F.J., Yanez-Benites C., Talal I., Blas J.L., Garau R., Clark-Stuart S., Wallace A., Di Carlo A., Wisnia E., Ehsan K., Beck-Sanders K., Godson E., Campbell P., Ahmad R., Ali R., Aswani S.S., Barza A., Carrillo C., Dawani A., Dey A., Elserafy A., Gaspar D., Lazzareschi L., Patel M., Shabana A., Shams M., Shams O., and Slack Z.

Subjects
Hot gallbladder, education, Weekend effect, COVID-19, Settore MED/18 - Chirurgia Generale, Retrospective Studie, Case-Control Studies, Emergency surgery, Hospital Mortality, Humans, Retrospective Studies, Pandemics, Emergency Medicine, Surgery, Case-Control Studie, Human
Abstract

Introduction The concept of “weekend effect”, that is, substandard healthcare during weekends, has never been fully demonstrated, and the different outcomes of emergency surgical patients admitted during weekends may be due to different conditions at admission and/or different therapeutic approaches. Aim of this international audit was to identify any change of pattern of emergency surgical admissions and treatments during weekends. Furthermore, we aimed at investigating the impact of the COVID-19 pandemic on the alleged “weekend effect”. Methods The database of the CovidICE-International Study was interrogated, and 6263 patients were selected for analysis. Non-trauma, 18+ yo patients admitted to 45 emergency surgery units in Europe in the months of March–April 2019 and March–April 2020 were included. Demographic and clinical data were anonymised by the referring centre and centrally collected and analysed with a statistical package. This study was endorsed by the Association of Italian Hospital Surgeons (ACOI) and the World Society of Emergency Surgery (WSES). Results Three-quarters of patients have been admitted during workdays and only 25.7% during weekends. There was no difference in the distribution of gender, age, ASA class and diagnosis during weekends with respect to workdays. The first wave of the COVID pandemic caused a one-third reduction of emergency surgical admission both during workdays and weekends but did not change the relation between workdays and weekends. The treatment was more often surgical for patients admitted during weekends, with no difference between 2019 and 2020, and procedures were more often performed by open surgery. However, patients admitted during weekends had a threefold increased risk of laparoscopy-to-laparotomy conversion (1% vs. 3.4%). Hospital stay was longer in patients admitted during weekends, but those patients had a lower risk of readmission. There was no difference of the rate of rescue surgery between weekends and workdays. Subgroup analysis revealed that interventional procedures for hot gallbladder were less frequently performed on patients admitted during weekends. Conclusions Our analysis revealed that demographic and clinical profiles of patients admitted during weekends do not differ significantly from workdays, but the therapeutic strategy may be different probably due to lack of availability of services and skillsets during weekends. The first wave of the COVID-19 pandemic did not impact on this difference.

Published
2022

19. Transcriptomics and metabolomics integration reveals redox-dependent metabolic rewiring in breast cancer cells

Author

Bonanomi, M, Salmistraro, N, Fiscon, G, Conte, F, Paci, P, Bravata, V, Forte, G, Volpari, T, Scorza, M, Mastroianni, F, D'Errico, S, Avolio, E, Piccialli, G, Colangelo, A, Vanoni, M, Gaglio, D, Alberghina, L, Bonanomi M., Salmistraro N., Fiscon G., Conte F., Paci P., Bravata V., Forte G. I., Volpari T., Scorza M., Mastroianni F., D'errico S., Avolio E., Piccialli G., Colangelo A. M., Vanoni M., Gaglio D., Alberghina L., Bonanomi, M, Salmistraro, N, Fiscon, G, Conte, F, Paci, P, Bravata, V, Forte, G, Volpari, T, Scorza, M, Mastroianni, F, D'Errico, S, Avolio, E, Piccialli, G, Colangelo, A, Vanoni, M, Gaglio, D, Alberghina, L, Bonanomi M., Salmistraro N., Fiscon G., Conte F., Paci P., Bravata V., Forte G. I., Volpari T., Scorza M., Mastroianni F., D'errico S., Avolio E., Piccialli G., Colangelo A. M., Vanoni M., Gaglio D., and Alberghina L.

Abstract

Rewiring glucose metabolism toward aerobic glycolysis provides cancer cells with a rapid generation of pyruvate, ATP, and NADH, while pyruvate oxidation to lactate guarantees refueling of oxidized NAD+ to sustain glycolysis. CtPB2, an NADH-dependent transcriptional co-regulator, has been proposed to work as an NADH sensor, linking metabolism to epigenetic transcriptional reprogramming. By integrating metabolomics and transcriptomics in a triple-negative human breast cancer cell line, we show that genetic and pharmacological down-regulation of CtBP2 strongly reduces cell proliferation by modulating the redox balance, nucleotide synthesis, ROS generation, and scavenging. Our data highlight the critical role of NADH in controlling the oncogene-dependent crosstalk between metabolism and the epigenetically mediated transcriptional program that sustains energetic and anabolic demands in cancer cells.

Published
2021

21. Atypical antipsychotics and oxidative cardiotoxicity: review of literature and future perspectives to prevent sudden cardiac death

Author

D'Errico, S., La Russa, R., Maiese, A., Santurro, A., Scopetti, M., Romano, S., Zanon, M., Frati, P., and Fineschi, V.

Subjects
atypical antipsychotics, oxidative stress, sudden cardiac death, Review
Abstract

Oxidative stress is considered the principal mediator of myocardial injury under pathological conditions. It is well known that reactive oxygen (ROS) or nitrogen species (RNS) are involved in myocardial injury and repair at the same time and that cellular damage is generally due to an unbalance between generation and elimination of the free radicals due to an inadequate mechanism of antioxidant defense or to an increase in ROS and RNS. Major adverse cardiovascular events are often associated with drugs with associated findings such as fibrosis or inflammation of the myocardium. Despite efforts in the preclinical phase of the development of drugs, cardiotoxicity still remains a great concern. Cardiac toxicity due to second-generation antipsychotics (clozapine, olanzapine, quetiapine) has been observed in preclinical studies and described in patients affected with mental disorders. A role of oxidative stress has been hypothesized but more evidence is needed to confirm a causal relationship. A better knowledge of cardiotoxicity mechanisms should address in the future to establish the right dose and length of treatment without impacting the physical health of the patients.

Published
2021

29. Finite element simulation of dynamic instabilities in frictional sliding contact

Author

Baillet, L., Linck, V., D'Errico, S., Laulagnet, B., and Berthier, Y.

Subjects
Friction -- Research, Tribology -- Research, Algorithms -- Research, Algorithms -- Technology application, Finite element method, Algorithm, Technology application, Science and technology
Abstract

This paper describes tools for numerical modeling which enable the understanding of the appearance of vibrations of a structure generated by the frictional contact between two bodies (the excitation source being friction). The dynamic finite element code PLASTD is used to reproduce transitory phenomena generated at the contact interface. This code includes contact and friction algorithms based upon a formulation which uses Lagrange multipliers. A numerical study of the dynamic response of a 2D mechanical model composed of a deformable body in relative translation and unilateral contact with Coulomb friction with a rigid surface is presented. The steady sliding solution is generically unstable and leads to a dynamic response which leads to the generation of instabilities characterized by the appearance of steady-state pulses. It is important to notice that those instabilities appear even with a constant friction coefficient of Coulomb. These simulations provided the local contact conditions (kinematics, tribological state, contact stresses, etc). The kinematics shows the existence of local impacts and sliding at high frequencies. Furthermore, local contact normal stress is found to be much higher than that expected for a smooth surface. Finally, a 3D simulation of brakes is carried out, focusing on the vibrations of the disk and the brake pad which produce noise and are due to the interface instabilities. Keywords: Friction, Instabilities, Contact, Dynamic, Finite Element

Published
2005

33. T06.01.9 THE BISPHENOL A INDUCED WORSENING OF NON-ALCOHOLIC FATTY LIVER DISEASE: A CLINICAL STRATEGY TO ANTAGONIZE THE PROGRESSION OF THE DISEASE

Author

Dallio, M., primary, Gravina, A.G., additional, Masarone, M., additional, Diano, N., additional, Nicolucci, C., additional, Errico, S., additional, Di Sarno, R., additional, Tuccillo, C., additional, Stiuso, P., additional, Morisco, F., additional, Persico, M., additional, Loguercio, C., additional, and Federico, A., additional

Published
2020
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35. The weekend effect on the provision of Emergency Surgery before and during the COVID-19 pandemic: case–control analysis of a retrospective multicentre database.

Author

Tebala, Giovanni D., Milani, Marika S., Cirocchi, Roberto, Bignell, Mark, Bond-Smith, Giles, Lewis, Christopher, Agnoletti, Vanni, Catarci, Marco, Di Saverio, Salomone, Luridiana, Gianluigi, Catena, Fausto, Scatizzi, Marco, Marini, Pierluigi, the CovidICE-International Collaborative, Lo Dico, R., Stracqualursi, A., Russo, G., D'Errico, S., Cianci, P., and Restini, E.

Subjects
AUDITING, LENGTH of stay in hospitals, OPERATIVE surgery, TIME, MEDICAL care, PATIENTS, CASE-control method, RETROSPECTIVE studies, ACQUISITION of data, SURGERY, HOSPITAL admission & discharge, GALLBLADDER diseases, EMERGENCY medical services, MEDICAL records, LAPAROSCOPY, ABDOMINAL surgery, DESCRIPTIVE statistics, COVID-19 pandemic
Abstract

Introduction: The concept of "weekend effect", that is, substandard healthcare during weekends, has never been fully demonstrated, and the different outcomes of emergency surgical patients admitted during weekends may be due to different conditions at admission and/or different therapeutic approaches. Aim of this international audit was to identify any change of pattern of emergency surgical admissions and treatments during weekends. Furthermore, we aimed at investigating the impact of the COVID-19 pandemic on the alleged "weekend effect". Methods: The database of the CovidICE-International Study was interrogated, and 6263 patients were selected for analysis. Non-trauma, 18+ yo patients admitted to 45 emergency surgery units in Europe in the months of March–April 2019 and March–April 2020 were included. Demographic and clinical data were anonymised by the referring centre and centrally collected and analysed with a statistical package. This study was endorsed by the Association of Italian Hospital Surgeons (ACOI) and the World Society of Emergency Surgery (WSES). Results: Three-quarters of patients have been admitted during workdays and only 25.7% during weekends. There was no difference in the distribution of gender, age, ASA class and diagnosis during weekends with respect to workdays. The first wave of the COVID pandemic caused a one-third reduction of emergency surgical admission both during workdays and weekends but did not change the relation between workdays and weekends. The treatment was more often surgical for patients admitted during weekends, with no difference between 2019 and 2020, and procedures were more often performed by open surgery. However, patients admitted during weekends had a threefold increased risk of laparoscopy-to-laparotomy conversion (1% vs. 3.4%). Hospital stay was longer in patients admitted during weekends, but those patients had a lower risk of readmission. There was no difference of the rate of rescue surgery between weekends and workdays. Subgroup analysis revealed that interventional procedures for hot gallbladder were less frequently performed on patients admitted during weekends. Conclusions: Our analysis revealed that demographic and clinical profiles of patients admitted during weekends do not differ significantly from workdays, but the therapeutic strategy may be different probably due to lack of availability of services and skillsets during weekends. The first wave of the COVID-19 pandemic did not impact on this difference. [ABSTRACT FROM AUTHOR]

Published
2022
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37. Management of the corpse with suspect, probable or confirmed COVID-19 respiratory infection - Italian interim recommendations for personnel potentially exposed to material from corpses, including body fluids, in morgue structures and during autopsy practice

Author

Fineschi, V., Aprile, A., Aquila, I., Arcangeli, M., Asmundo, A., Bacci, M., Cingolani, M., Cipolloni, L., D'Errico, S., de Casamassimi, I., Mizio, G. D., Paolo, M. D., Focardi, M., Frati, P., Gabbrielli, M., Russa, R. L., Maiese, A., Manetti, F., Martelloni, M., Mazzeo, E., Montana, A., Neri, M., Padovano, M., Pinchi, V., Pomara, C., Ricci, P., Salerno, M., Santurro, A., Scopetti, M., Testi, R., Turillazzi, E., Vacchiano, G., Crivelli, F., Bonoldi, E., Facchetti, F., Nebuloni, M., Sapino, A., Fineschi, Vittorio, Aprile, Anna, Aquila, Isabella, Arcangeli, Mauro, Asmundo, Alessio, Bacci, Mauro, Cingolani, Mariano, Cipolloni, Luigi, D'Errico, Stefano, De Casamassimi, Ilaria, Di Mizio, Giulio, Di Paolo, Marco, Focardi, Martina, Frati, Paola, Gabbrielli, Mario, La Russa, Raffaele, Maiese, Aniello, Manetti, Federico, Martelloni, Massimo, Mazzeo, Elena, Montana, Angelo, Neri, Margherita, Padovano, Martina, Pinchi, Vilma, Pomara, Cristoforo, Ricci, Pietrantonio, Salerno, Monica, Santurro, Alessandro, Scopetti, Matteo, Testi, Roberto, Turillazzi, Emanuela, Vacchiano, Giuseppe, Crivelli, Filippo, Bonoldi, Emanuela, Facchetti, Fabio, Nebuloni, Manuela, and Sapino, Anna

Subjects
safety, COVID-19, autopsy, guidelines, COVID19, Health Personnel, Pneumonia, Viral, NO, Betacoronavirus, Cadaver, Humans, Autopsy, Body Fluids, Coronavirus Infections, Italy, Morgue, Pandemics, Personal Protective Equipment, Viral, Autopsy, Body Fluids, COVID-19, Cadaver, Coronavirus Infections, Health Personnel, Humans, Italy, Morgue, Pandemics, Personal Protective Equipment, SARS-CoV-2, Pneumonia, guideline, Autopsy, Body Fluids, COVID-19, Cadaver, Coronavirus Infections, Health Personnel, Humans, Italy, Morgue, Pandemics, Personal Protective Equipment, Pneumonia, Viral, SARS-CoV-2, Betacoronavirus
Abstract

non disponibile

Published
2020

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