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Your search keyword '"D. A. Lopez-Ramos"' showing total 3 results
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3 results on '"D. A. Lopez-Ramos"'

1. Immunity to retrovirus infection (PP-075)

Author

M. Metzner, S. Takamura, E. A. Putilova, T. M. A. Carmo, Y. Shimizu, M. A. S. Zarife, H. Jäck, A. Hasegawa, A. Utsunomiya, R. S. Accolla, T. Okudaira, M. G. Reis, M. Maeda, H. Masutani, Y. Tamai, M. Bouzari, L. Zuo, I. Hoof, M. Kato, M. Nielsen, Y. Maeda, Z. Mortezaie, I. Choi, K. V. Gaidul, L. A. R. Freitas, A. Takamori, H. Rafat panah Bayegi, E. Takeda, R. Roghanian, M. Buggert, F. A. Pereira, E. Yoshihara, R. Tanosaki, I. A. Goldina, R. K. L. Gustafsson, X. Zhao, N. Zeng, B. G. Goldin, J. Yodoi, R. Paraná, Z. Chen, G. Tosi, T. Chikaishi, M. Kannagi, M. Miyazawa, M. Azarpajooh, C. Orlandi, N. Moheghi, N. Uike, S. Kimura, M. Masuda, J. Tavakkol Afshari, E. Kajiwara, S. Kawahara, I. V. Safronova, L. A. O. S. Pereira, M. Wabl, R. Ralte, A. C. Karlsson, C. L. Pérez, D. A. Lopez-Ramos, V. A. Ivanis, O. Lund, K. Hase, Y. Yamano, J. Okamura, H. Ohno, K. Sugie, and L. J. Ren

Subjects
Retrovirus, biology, Immunity, Immunology, Immunology and Allergy, General Medicine, biology.organism_classification, Virology
Published
2010

2. Thioredoxin-binding protein-2 (TBP-2/VDUP1/TXNIP) regulates T-cell sensitivity to glucocorticoid during HTLV-I-induced transformation

Author

K Sugie, Yasuhiro Maeda, Hiroshi Masutani, Michiyuki Maeda, Junji Yodoi, Eiji Yoshihara, Zhe Chen, and D. A. Lopez-Ramos

Subjects
Cancer Research, Programmed cell death, Tumor suppressor gene, T cell, T-Lymphocytes, Biology, Hydroxamic Acids, Cell Line, Glucocorticoid receptor, Receptors, Glucocorticoid, thioredoxin-binding protein-2/thioredoxin-interacting protein, medicine, glucocorticoid receptor, Humans, Leukemia-Lymphoma, Adult T-Cell, Glucocorticoids, Human T-lymphotropic virus 1, Vorinostat, apoptosis, Hematology, Transfection, Cell Transformation, Viral, HTLV-I, medicine.anatomical_structure, Oncology, Cell culture, Apoptosis, ATL, Cancer research, Original Article, glucocorticoid, Carrier Proteins, TXNIP
Abstract

Although glucocorticoid (GC) is widely used for treating hematopoietic malignancies including adult T-cell leukemia (ATL), the mechanism by which leukemic cells become resistant to GC in the clinical course remains unclear. Using a series of T-cell lines infected with human T lymphotropic virus type-I (HTLV-I), the causative virus of ATL, we have dissected the transformation from interleukin (IL)-2-dependent to -independent growth stage. The transformation associates the loss of thioredoxin-binding protein-2 (TBP-2), a tumor suppressor and regulator of lipid metabolism. Here we show that TBP-2 is responsible for GC-induced apoptosis in ATL cells. In the IL-2-dependent stage, dexamethasone induced TBP-2 expression and apoptosis, both of which were blocked by GC receptor (GR) antagonist RU486. Knockdown of TBP-2 consistently reduced the amount of GC-induced apoptosis. In IL-2-independent stage, however, expression of GR and TBP-2 was suppressed and GC failed to induce apoptosis. Forced expression of GR led the cells to mild sensitivity to GC, which was also accomplished by treatment with suberoylanilide hydroxamic acid, a TBP-2 inducer. A transfection experiment showed that TBP-2 expression induced apoptosis in IL-2-independent ATL cells. Thus, TBP-2 is likely to be one of the key molecules for GC-induced apoptosis and a potential target for treating the advanced stage of ATL.

Published
2010

3. NO and ROS in immune responses (WS-005)

Author

L. Kong, K. Fuchs, A. Donko, Shahrzad Zamani, Y. Hoshino, Junji Yodoi, D. A. Lopez-Ramos, M. Rojewski, Hubert Schrezenmeier, Z. Benyo, G. Solgi, T. Nishiya, Maryam Rastin, Nafiseh Tabasi, S. Miwa, Kouetsu Ogasawara, Ramin Lotfi, Y. Matsuo, Quentin J. Sattentau, A. Emami, B. Enyedi, Mahmoud Mahmoudi, E. Ruisanchez, Katsuji Sugie, M. Fujimuro, A. Meister, M. Geiszt, T. Yildiz, Z. Siadat, A. E. Moghaddam, S. Maekawa, Eiji Yoshihara, T. Uehara, Zhe Chen, Kate H. Gartlan, M. Iranshahi, and A. Orient

Subjects
Immunology, Immunology and Allergy, General Medicine
Published
2010

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