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1. Synthesis of new potentially biologically active pyranopyridones with tryptamine fragment

Author

G. P. Tokmakov, Victor A. Tafeenko, N. M. Przhevalskii, R. K. Laypanov, I. V. Lukina, and D. A. Vershinkin

Subjects
Tryptamine, biology, 010405 organic chemistry, Stereochemistry, food and beverages, Biological activity, General Chemistry, 010402 general chemistry, biology.organism_classification, 01 natural sciences, 0104 chemical sciences, chemistry.chemical_compound, chemistry, Allium, Malononitrile, Primary screening
Abstract

New pyranopyridonotryptamines 3 were synthesized by a three-component reaction of pyridonotryptamines 1, aromatic aldehydes 2, and malononitrile. The structures of compounds 3 were confirmed by X-ray crystallography. A series of compounds 3 underwent primary screening for the effect on the course of mitosis in seeds of plants of the species Allium cepa L.

Published
2021

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