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1. P461 ECG MONITORING TO DETECT ATRIAL FIBRILLATION IN PATIENT WITH CRYPTOGENIC ISCHEMIC STROKE

Author

M Bolognesi, D Guidetti, L Rossi, A Biagi, P Immovilli, and D Aschieri

Subjects
Cardiology and Cardiovascular Medicine
Abstract

Backgroound It’s Known that atrial fibrillation ( AF) is related to 20 % of ischemic stroke, but it is also found in one third of cryptogenetic, lacunar, atherotrombotic stroke. After stroke cardiac test are reccomended . 24 h holter ECG has a diagnostic yield about 1 – 5 % .Nowadays exists diagnostic test for ECG monitoring with a major diagnostic yield, but they are reccomended only in selected stroke patients Methods We considered consecutively 256 pazienti hospitalized in Neurology Division with ischemic stroke or transient ischemic attack ( TIA) from February to December 2022 recepient of 24 h or 72 h Holter ECG executed in Cardiology division. We evaluated AF registration, < 30 sec atrial tachicardia ( TA) and cerebral lesions. Results Out of 256 patients, with average 77±19 anni years, 149 ( 58%)were males and 105 ( 42%) females with average CHA2DS2VAS 4. AF was detected from 24 – 72 h Holter ECG 24 h – 72 in 11 patients ( 3,9%)with average age 84 years and CHA2DS2VASC 5 . The effective diagnotic yield was 3,1%. Considering cerebral injury imaging of acute stroke iun patients with AF, 3 patient had cortical injury ( one of these with early Hemorragic infarction), 2 con lesioni cortico– subcortical lesions, 2 lacunar lesions e 3 without lesions. We found < 30 seconds atrial tachicardia in 20 patients ( 8%) with average age 80 years e CHA2Ds2VAS 5 Cerebral lesions of these patients were : 5 lacunar lesions, 5 cortical lesion in multiple region, 3 cortico subcortical, 1 corticali, 2 lesions from atherotrombotic etiology, 4 without lesions Conclusions In out experience we confirm a 24 – 72 h Holter ECG low diagnostic yield to AF diagnosis more frequent in older patients with high CHA2DSAVSC score. Porolonged ECG monitoring can be considered in parients with cortico subcortical or cortical in multiple territories and with < 30 seconds AT detected at 24 – 72 holter ECG .

Published
2023

2. Cavezzo, the first Italian meteorite recovered by the PRISMA fireball network. Orbit, trajectory, and strewn-field

Author

C. A. Volpicelli, Enrico Cascone, M. Belluso, Stefano Basso, Riccardo Smareglia, Cyril Blanpain, A. Andreis, G. Monti, M. E. Bertaina, S. Masiero, Tonino Pisanu, G. Interrante, F. Lippolis, G. Tigani Sava, G. Valente, D. Barghini, Sonia Zorba, Alberto Buzzoni, V. Gagliarducci, M. Soldi, Fabio Manca, Cristina Knapic, Cristian Carli, M. Montesarchio, Giovanni Pratesi, S. Rubinetti, D. Licchelli, T. Avoscan, A. Misiano, D. Cricchio, F. Federici, P. Colombetti, M. Romeo, G. Ascione, Daniele Gardiol, Alberto Cellino, A. Gerardi, François Colas, M. Suvieri, F. Strafella, R. Di Luca, F. Bernardi, A. Nastasi, J. L. Rault, S. Jeanne, C. Simoncelli, R. Stanga, Monica Lazzarin, C. Romeni, C. Cattaneo, S. Rasetti, Albino Carbognani, A. Malgoyre, Jader Monari, P. Demaria, Carla Taricco, M. Tombelli, Gabriele Giuli, Giuseppe Leto, A. Di Dato, N. Rizzi, M. Di Carlo, R. Serra, A. Pegoraro, Sylvain Bouley, S. Pietronave, Matteo Albani, R. Baldini, D. Guidetti, F. Salvati, M. Montemaggi, G. D’Agostino, Elisa Londero, A. Zollo, Chiara Marmo, F. Mannucci, W. Riva, J. Vaubaillon, Brigitte Zanda, Mirel Birlan, M. Rigoni, P. Morini, Jérôme Gattacceca, U. Repetti, M. Pavone, R. Zagarella, G. Cremonese, S. Meucci, S. Lera, R. Bellitto, M. D’Elia, A. Balestrero, F. Affaticati, M. De Maio, T. Carriero, R. Masi, S. Mancuso, Giovanni B. Valsecchi, Emilio Molinari, N. Pugno, R. Salerno, R. Bonino, R. Pardini, Pierre Vernazza, P. Russo, A. Bussi, V. Moggi Cecchi, C. Benna, G. M. Stirpe, K. Boros, J. Lecubin, P. Bacci, Gabriele Umbriaco, M. Costa, D. Selvestrel, E. Pace, M. Di Martino, R. Vairetti, E. Colombi, L. Betti, P. Trivero, P. Volpini, Institut de Mécanique Céleste et de Calcul des Ephémérides (IMCCE), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Lille-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Centre européen de recherche et d'enseignement des géosciences de l'environnement (CEREGE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Collège de France (CdF (institution))-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Laboratoire d'Astrophysique de Marseille (LAM), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Collège de France (CdF (institution))-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Recherche Agronomique (INRA), Gardiol, D., Barghini, D., Buzzoni, A., Carbognani, A., Di Carlo, M., Di Martino, M., Knapic, C., Londero, E., Pratesi, G., Rasetti, S., Riva, W., Salerno, R., Stirpe, G. M., Valsecchi, G. B., Volpicelli, C. A., Zorba, S., Colas, F., Zanda, B., Bouley, S., Jeanne, S., Malgoyre, A., Birlan, M., Blanpain, C., Gattacceca, J., Lecubin, J., Marmo, C., Rault, J. L., Vaubaillon, J., Vernazza, P., Affaticati, F., Albani, M., Andreis, A., Ascione, G., Avoscan, T., Bacci, P., Baldini, R., Balestrero, A., Basso, S., Bellitto, R., Belluso, M., Benna, C., Bernardi, F., Bertaina, M. E., Betti, L., Bonino, R., Boros, K., Bussi, A., Carli, C., Carriero, T., Cascone, E., Cattaneo, C., Cellino, A., Colombetti, P., Colombi, E., Costa, M., Cremonese, G., Cricchio, D., D'Agostino, G., D'Elia, M., De Maio, M., Demaria, P., Di Dato, A., Di Luca, R., Federici, F., Gagliarducci, V., Gerardi, A., Giuli, G., Guidetti, D., Interrante, G., Lazzarin, M., Lera, S., Leto, G., Licchelli, D., Lippolis, F., Manca, F., Mancuso, S., Mannucci, F., Masi, R., Masiero, S., Meucci, S., Misiano, A., Moggi Cecchi, V., Molinari, E., Monari, J., Montemaggi, M., Montesarchio, M., Monti, G., Morini, P., Nastasi, A., Pace, E., Pardini, R., Pavone, M., Pegoraro, A., Pietronave, S., Pisanu, T., Pugno, N., Repetti, U., Rigoni, M., Rizzi, N., Romeni, C., Romeo, M., Rubinetti, S., Russo, P., Salvati, F., Selvestrel, D., Serra, R., Simoncelli, C., Smareglia, R., Soldi, M., Stanga, R., Strafella, F., Suvieri, M., Taricco, C., Tigani Sava, G., Tombelli, M., Trivero, P., Umbriaco, G., Vairetti, R., Valente, G., Volpini, P., Zagarella, R., Zollo, A., Gardiol D., Barghini D., Buzzoni A., Carbognani A., Di Carlo M., Di Martino M., Knapic C., Londero E., Pratesi G., Rasetti S., Riva W., Salerno R., Stirpe G.M., Valsecchi G.B., Volpicelli C.A., Zorba S., Colas F., Zanda B., Bouley S., Jeanne S., Malgoyre A., Birlan M., Blanpain C., Gattacceca J., Lecubin J., Marmo C., Rault J.L., Vaubaillon J., Vernazza P., Affaticati F., Albani M., Andreis A., Ascione G., Avoscan T., Bacci P., Baldini R., Balestrero A., Basso S., Bellitto R., Belluso M., Benna C., Bernardi F., Bertaina M.E., Betti L., Bonino R., Boros K., Bussi A., Carli C., Carriero T., Cascone E., Cattaneo C., Cellino A., Colombetti P., Colombi E., Costa M., Cremonese G., Cricchio D., D'Agostino G., D'Elia M., De Maio M., Demaria P., Di Dato A., Di Luca R., Federici F., Gagliarducci V., Gerardi A., Giuli G., Guidetti D., Interrante G., Lazzarin M., Lera S., Leto G., Licchelli D., Lippolis F., Manca F., Mancuso S., Mannucci F., Masi R., Masiero S., Meucci S., Misiano A., Moggi Cecchi V., Molinari E., Monari J., Montemaggi M., Montesarchio M., Monti G., Morini P., Nastasi A., Pace E., Pardini R., Pavone M., Pegoraro A., Pietronave S., Pisanu T., Pugno N., Repetti U., Rigoni M., Rizzi N., Romeni C., Romeo M., Rubinetti S., Russo P., Salvati F., Selvestrel D., Serra R., Simoncelli C., Smareglia R., Soldi M., Stanga R., Strafella F., Suvieri M., Taricco C., Tigani Sava G., Tombelli M., Trivero P., Umbriaco G., Vairetti R., Valente G., Volpini P., Zagarella R., Zollo A., and ITA

Subjects
meteoroids -methods: data analysis -techniques: image processing, 010502 geochemistry & geophysics, 01 natural sciences, Strewn field, meteorites, 0103 physical sciences, meteors, meteoroids, 010303 astronomy & astrophysics, meteoroid, 0105 earth and related environmental sciences, Physics, Meteoroid, image processing, methods: data analysis, techniques, meteor, Astronomy, Astronomy and Astrophysics, meteorite, Meteorite, Space and Planetary Science, [SDU]Sciences of the Universe [physics], data analysi [methods], Trajectory, Orbit (control theory)
Abstract

Two meteorite pieces have been recovered in Italy, near the town of Cavezzo (Modena), on 2020 January 4th. The associated fireball was observed on the evening of New Year’s Day 2020 by eight all-sky cameras of the PRISMA fireball network, a partner of FRIPON. The computed trajectory had an inclination angle of approximately 68° and a velocity at infinity of 12.8 km s−1. Together with the relatively low terminal height, estimated as 21.5 km, those values were indicating the significant possibility of a meteorite dropping event, as additionally confirmed by the non-zero residual total mass. The strewn-field was computed taking into account the presence of two bright light flashes, revealing that the meteoroid had been very likely subject to fragmentation. Three days after the event, two samples, weighing 3.1 and 52.2 g, were collected as a result of a dedicated field search and thanks to the involvement of the local people. The two pieces were immediately recognized as freshly fallen fragments of meteorite. The computed orbital elements, compared with the ones of known Near-Earth Asteroids from the NEODyS database, are compatible with one asteroid only; 2013 VC10. The estimated original mass of the meteoroid, 3.5 kg, and size, approximately 13 cm, is so far the smallest among the current 35 cases in which meteorites were recovered from precise strewn-field computation thanks to observational data. This result demonstrates the effectiveness of accurate processing of fireball network data even on challenging events generated by small size meteoroids.

Published
2021

3. Searching for obscured AGN in z ~ 2 submillimetre galaxies

Author

Isabella Prandoni, Hai-Bo Chen, T. W. B. Muxlow, Megan Argo, I. M. McHardy, M. A. Garrett, D. Guidetti, Peter Barthel, Robert Beswick, S. Chi, David M. Alexander, Ian Smail, M. Bondi, Alasdair Thomson, Nicholas Wrigley, and J. F. Radcliffe

Subjects
European VLBI Network, Active galactic nucleus, 85A15, media_common.quotation_subject, Population, FOS: Physical sciences, Astrophysics, 01 natural sciences, 0103 physical sciences, Very-long-baseline interferometry, education, 010303 astronomy & astrophysics, media_common, Physics, High Energy Astrophysical Phenomena (astro-ph.HE), education.field_of_study, F990, 010308 nuclear & particles physics, Astronomy and Astrophysics, Astrophysics - Astrophysics of Galaxies, Galaxy, Universe, Redshift, Space and Planetary Science, Brightness temperature, Astrophysics of Galaxies (astro-ph.GA), Astrophysics - High Energy Astrophysical Phenomena
Abstract

Submillimetre-selected galaxies (SMGs) at high redshift ($z$ $\sim$ 2) are potential host galaxies of active galactic nuclei (AGN). If the local Universe is a good guide, $\sim$ 50$\%$ of the obscured AGN amongst the SMG population could be missed even in the deepest X-ray surveys. Radio observations are insensitive to obscuration; therefore, very long baseline interferometry (VLBI) can be used as a tool to identify AGN in obscured systems. A well-established upper limit to the brightness temperature of 10$^5$ K exists in star-forming systems, thus VLBI observations can distinguish AGN from star-forming systems via brightness temperature measurements. We present 1.6 GHz European VLBI Network (EVN) observations of four SMGs (with measured redshifts) to search for evidence of compact radio components associated with AGN cores. For two of the sources, e-MERLIN images are also presented. Out of the four SMGs observed, we detect one source, J123555.14, that has an integrated EVN flux density of 201 $\pm$ 15.2 $\mu$Jy, corresponding to a brightness temperature of 5.2 $\pm$ 0.7 $\times$ 10$^5$ K. We therefore identify that the radio emission from J123555.14 is associated with an AGN. We do not detect compact radio emission from a possible AGN in the remaining sources (J123600.10, J131225.73, and J163650.43). In the case of J131225.73, this is particularly surprising, and the data suggest that this may be an extended, jet-dominated AGN that is resolved by VLBI. Since the morphology of the faint radio source population is still largely unknown at these scales, it is possible that with a $\sim$ 10 mas resolution, VLBI misses (or resolves) many radio AGN extended on kiloparsec scales., Comment: 11 pages, 5 figures

Published
2020

4. The e-MERGE Survey (e-MERLIN Galaxy Evolution Survey): overview and survey description

Author

Edo Ibar, Luitje Koopmans, A. D. Biggs, Isabella Prandoni, T. K. Garratt, M. K. Argo, Alasdair Thomson, Mark Sargent, Kristen Coppin, H. Chen, J. M. Simpson, Robert Beswick, A. M. Swinbank, P. N. Best, I. M. McHardy, M. Bondi, David Bacon, Ian Smail, A. Njeri, Eskil Varenius, Jean-Paul Kneib, J. F. Radcliffe, Rob Ivison, Tiziana Venturi, Scott Chapman, Matt J. Jarvis, Kirsten Kraiberg Knudsen, Chris Pearson, A. M. S. Richards, Miguel A. Pérez-Torres, Simon Garrington, D. Guidetti, Charles E. Simpson, N. Wrigley, H. J. A. Röttgering, T. W. B. Muxlow, M. A. Garrett, Leah K. Morabito, Eric J. Murphy, Stephen Serjeant, Laboratoire d'Astrophysique de Marseille (LAM), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Science and Technology Facilities Council (UK), South African Astronomical Observatory, Istituto Nazionale di Astrofisica, Fondo Nacional de Desarrollo Científico y Tecnológico (Chile), European Commission, and Astronomy

Subjects
radio-emission, Active galactic nucleus, star-formation history, media_common.quotation_subject, alma survey, F500, galaxies [Radio continuum], Astrophysics::Cosmology and Extragalactic Astrophysics, Astrophysics, high-resolution, 01 natural sciences, high-redshift [Galaxies], 0103 physical sciences, Galaxy formation and evolution, Surface brightness, ghz observations, wide-field, 010303 astronomy & astrophysics, Astrophysics::Galaxy Astrophysics, submillimeter galaxies, media_common, radio continuum: galaxies, Physics, [SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], 010308 nuclear & particles physics, Galaxies: high-redshift, forming galaxies, Galaxies: evolution, Astronomy and Astrophysics, evolution [Galaxies], Astrophysics - Astrophysics of Galaxies, Galaxy, Interferometry, [SDU]Sciences of the Universe [physics], Space and Planetary Science, Sky, Data analysis, data reduction, hubble-deep-field, Merge (version control)
Abstract

Full list of authors: Muxlow, T. W. B.; Thomson, A. P.; Radcliffe, J. F.; Wrigley, N. H.; Beswick, R. J.; Smail, Ian; McHardy, I. M.; Garrington, S. T.; Ivison, R. J.; Jarvis, M. J.; Prandoni, I.; Bondi, M.; Guidetti, D.; Argo, M. K.; Bacon, David; Best, P. N.; Biggs, A. D.; Chapman, S. C.; Coppin, K.; Chen, H.; Garratt, T. K.; Garrett, M. A.; Ibar, E.; Kneib, Jean-Paul; Knudsen, Kirsten K.; Koopmans, L. V. E.; Morabito, L. K.; Murphy, E. J.; Njeri, A.; Pearson, Chris; Pérez-Torres, M. A.; Richards, A. M. S.; Röttgering, H. J. A.; Sargent, M. T.; Serjeant, Stephen; Simpson, C.; Simpson, J. M.; Swinbank, A. M.; Varenius, E.; Venturi, T., We present an overview and description of the e-MERGE Survey (e-MERLIN Galaxy Evolution Survey) Data Release 1 (DR1), a large program of high-resolution 1.5-GHz radio observations of the GOODS-N field comprising similar to 140 h of observations with enhanced-Multi-Element Remotely Linked Interferometer Network (e-MERLIN) and similar to 40 h with the Very Large Array (VLA). We combine the long baselines of e-MERLIN (providing high angular resolution) with the relatively closely packed antennas of the VLA (providing excellent surface brightness sensitivity) to produce a deep 1.5-GHz radio survey with the sensitivity (similar to 1.5 mu Jy beam(-1)), angular resolution (0.2-0.7 arcsec) and field-of-view (similar to 15x15 arcmin(2)) to detect and spatially resolve star-forming galaxies and active galactic nucleus (AGN) at z greater than or similar to 1. The goal of e-MERGE is to provide new constraints on the deep, sub-arcsecond radio sky which will be surveyed by SKA1-mid. In this initial publication, we discuss our data analysis techniques, including steps taken to model in-beam source variability over an similar to 20-yr baseline and the development of newpoint spread function/primary beam models to seamlessly merge e-MERLIN and VLA data in the uv plane. We present early science results, including measurements of the luminosities and/or linear sizes of similar to 500 galaxies selected at 1.5 GHz. In combination with deep Hubble Space Telescope observations, we measure a mean radio-to-optical size ratio of r(e-MERGE)/r(HST) similar to 1.02 +/- 0.03, suggesting that in most high-redshift galaxies, the similar to GHz continuum emission traces the stellar light seen in optical imaging. This is the first in a series of papers that will explore the similar to kpc-scale radio properties of star-forming galaxies and AGN in the GOODS-N field observed by e-MERGE DR1. © 2020 The Author(s)., APT, TWBM, RJB, and MAG acknowledge support from STFC (ST/P000649/1). APT further acknowledges and thanks Robert Dickson, Peter Draper, David Hempston, Anthony Holloway, and Alan Lotts for their extensive support managing the highperformance computing infrastructure, which has been essential for the successful delivery of e-MERGE DR1. JFR acknowledges the financial assistance of the South African Radio Astronomy Observatory (SARAO) towards this research (http://sarao.ac.za).IP acknowledges support from INAF under the PRIN SKA/CTA project 'FORECaST' and the PRIN MAIN STREAM project 'SAuROS'. EI acknowledges partial support from FONDECYT through grant no 1171710. We thank the anonymous reviewer for their detailed and constructive referee report, which has undoubtedly improved the quality of the final manuscript. e-MERLIN is a National Facility operated by the University of Manchester at Jodrell Bank Observatory on behalf of STFC. The National Radio Astronomy Observatory is a facility of the National Science Foundation operated under cooperative agreement by Associated Universities, Inc. The authors acknowledge the use of the IRIDIS High Performance Computing Facility, and associated support services at the University of Southampton, in the completion of this work. We thank IRIS (www.iris.ac.uk) for provision of highperformance computing facilities. STFC IRIS is investing in the UK's Radio and mm/sub-mm Interferometry Services in order to improve data quality and throughput. The European VLBI Network is a joint facility of independent European, African, Asian, and North American radio astronomy institutes. Scientific results from data presented in this publication are derived from the following EVN project code(s): EG078B. The research leading to these results has received funding from the European Commission Horizon 2020 Research and Innovation Programme under grant agreement no. 730562 (RadioNet)., With funding from the Spanish government through the ‘Severo Ochoa Centre of Excellence’ accreditation SEV-2017-0709.

Published
2020

5. XVII Convegno Nazionale di 'Il linguaggio della Ricerca'

Author

S. Bardelli, L. Bellucci, V.Biasini, L. Capotondi, R. Del Coco, A. Degli Esposti, P. Galizia, S. Gamberini, D. Guidetti, S. Giuliani, R. Lapinska-Viola, G. Lattanzi, M. Orlandini, G. Sotgiu, and M. Tassistro e A. Zanelli

Subjects
ricerca-scuola, divulgazione, Il linguaggio della ricerca
Abstract

Il Linguaggio della Ricerca (LdR) è un progetto nato a Bologna nel 2003 per suscitare l'interesse dei giovani nei confronti della ricerca scientifica, mediante un coinvolgimento nella divulgazione dei contenuti appresi, utilizzando l'italiano e l'inglese. Si è così creata una sinergia fra il mondo della Scuola e della Ricerca, integrando l'esperienza dei ricercatori, le capacità didattiche degli insegnanti delle Scuole Secondarie di I e II grado e la creatività degli studenti. Sito web: https://ldr-network.bo.cnr.it/

Published
2020

6. The Prognostic Roles of Gender and O6-Methylguanine-DNA Methyltransferase Methylation Status in Glioblastoma Patients: The Female Power

Author

Enrico Franceschi, Alicia Tosoni, Santino Minichillo, Roberta Depenni, Alexandro Paccapelo, Stefania Bartolini, Maria Michiara, Giacomo Pavesi, Benedetta Urbini, Girolamo Crisi, Michele A. Cavallo, Luigino Tosatto, Claudio Dazzi, Claudia Biasini, Giuseppe Pasini, Damiano Balestrini, Francesca Zanelli, Vania Ramponi, Antonio Fioravanti, Ermanno Giombelli, Dario De Biase, Agostino Baruzzi, Alba A. Brandes, A. Baruzzi, F. Albani, F. Calbucci, R. D'Alessandro, R. Michelucci, A. Brandes, V. Eusebi, S. Ceruti, E. Fainardi, R. Tamarozzi, E. Emiliani, M. Cavallo, E. Franceschi, A. Tosoni, F. Fiorica, A. Valentini, R. Depenni, C. Mucciarini, G. Crisi, E. Sasso, C. Biasini, L. Cavanna, D. Guidetti, N. Marcello, A. Pisanello, A.M. Cremonini, G. Guiducci, S. de Pasqua, S. Testoni, R. Agati, G. Ambrosetto, A. Bacci, E. Baldin, A. Baldrati, E. Barbieri, S. Bartolini, E. Bellavista, F. Bisulli, E. Bonora, F. Bunkheila, V. Carelli, M. Crisci, P. Dall'Occa, D. de Biase, S. Ferro, C. Franceschi, G. Frezza, V. Grasso, M. Leonardi, G. Marucci, L. Morandi, B. Mostacci, G. Palandri, E. Pasini, M. Pastore Trossello, A. Pession, R. Poggi, P. Riguzzi, R. Rinaldi, S. Rizzi, G. Romeo, F. Spagnolli, P. Tinuper, C. Trocino, M. Dall'Agata, M. Frattarelli, G. Gentili, A. Giovannini, P. Iorio, U. Pasquini, G. Galletti, C. Guidi, W. Neri, A. Patuelli, S. Strumia, M. Faedi, M. Casmiro, A. Gamboni, F. Rasi, G. Cruciani, P. Cenni, C. Dazzi, A.R. Guidi, F. Zumaglini, A. Amadori, G. Pasini, M. Pasquinelli, E. Pasquini, A. Polselli, A. Ravasio, B. Viti, M. Sintini, A. Ariatti, F. Bertolini, G. Bigliardi, P. Carpeggiani, F. Cavalleri, S. Meletti, P. Nichelli, E. Pettorelli, G. Pinna, E. Zunarelli, F. Artioli, I. Bernardini, M. Costa, G. Greco, R. Guerzoni, C. Stucchi, C. Iaccarino, M. Ragazzi, R. Rizzi, G. Zuccoli, P. Api, F. Cartei, M. Colella, E. Fallica, M. Farneti, A. Frassoldati, E. Granieri, F. Latini, C. Monetti, A. Saletti, R. Schivalocchi, S. Sarubbo, S. Seraceni, M.R. Tola, B. Urbini, G. Zini, C. Giorgi, E. Montanari, D. Cerasti, P. Crafa, I. Dascola, I. Florindo, E. Giombelli, S. Mazza, V. Ramponi, F. Servadei, E.M. Silini, P. Torelli, P. Immovilli, N. Morelli, C. Vanzo, C. Nobile, Franceschi, Enrico, Tosoni, Alicia, Minichillo, Santino, Depenni, Roberta, Paccapelo, Alexandro, Bartolini, Stefania, Michiara, Maria, Pavesi, Giacomo, Urbini, Benedetta, Crisi, Girolamo, Cavallo, Michele A., Tosatto, Luigino, Dazzi, Claudio, Biasini, Claudia, Pasini, Giuseppe, Balestrini, Damiano, Zanelli, Francesca, Ramponi, Vania, Fioravanti, Antonio, Giombelli, Ermanno, De Biase, Dario, Baruzzi, Agostino, Brandes, Alba A., PERNO Study Group, Francesca, Bisulli, Valerio, Carelli, and Paolo, Tinuper

Subjects
Oncology, Adult, Male, medicine.medical_specialty, Multivariate analysis, Methyltransferase, Kaplan-Meier Estimate, DNA methyltransferase, Methylation, NO, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Biomarkers, Tumor, Medicine, Humans, DNA Modification Methylases, Aged, Proportional Hazards Models, Sex Characteristics, PERNO, business.industry, Brain Neoplasms, Standard treatment, Tumor Suppressor Proteins, Hazard ratio, Gender, DNA Methylation, Middle Aged, medicine.disease, Glioblastoma, MGMT, Prognosis, Confidence interval, DNA Repair Enzymes, 030220 oncology & carcinogenesis, Surgery, Neurology (clinical), Female, business, 030217 neurology & neurosurgery
Abstract

Background: Clinical and molecular factors are essential to define the prognosis in patients with glioblastoma (GBM). O6-methylguanine-DNA methyltransferase (MGMT) methylation status, age, Karnofsky Performance Status (KPS), and extent of surgical resection are the most relevant prognostic factors. Our investigation of the role of gender in predicting prognosis shows a slight survival advantage for female patients. Methods: We performed a prospective evaluation of the Project of Emilia Romagna on Neuro-Oncology (PERNO) registry to identify prognostic factors in patients with GBM who received standard treatment. Results: A total of 169 patients (99 males [58.6%] and 70 females [41.4%]) were evaluated prospectively. MGMT methylation was evaluable in 140 patients. Among the male patients, 36 were MGMT methylated (25.7%) and 47 were unmethylated (33.6%); among the female patients, 32 were methylated (22.9%) and 25 were unmethylated (17.9%). Survival was longer in the methylated females compared with the methylated males (P = 0.028) but was not significantly different between the unmethylated females and the unmethylated males (P = 0.395). In multivariate analysis, gender and MGMT methylation status considered together (methylated females vs. methylated males; hazard ratio [HR], 0.459; 95% confidence interval [CI], 0.242-0.827; P = 0.017), age (HR, 1.025; 95% CI, 1.002-1.049; P = 0.032), and KPS (HR, 0.965; 95% CI, 0.948-0.982; P < 0.001) were significantly correlated with survival. Conclusions: Survival was consistently longer among MGMT methylated females compared with males. Gender can be considered as a further prognostic factor.

Published
2018

7. The spectum of Notch3 mutations in 28 Italian CADASIL families

Author

Dott, M. T. A. Federico, R. Mazzei, S. Bianchi, O. Scali, F. L. Conforti, T. Sprovieri, D. Guidetti, U. Aguglia, D. COnsoli, L. Pantoni, C. Sarti, D. Inzitari, A. Quattrone

Subjects
Gene mutations -- Analysis, Cerebrovascular disease -- Analysis, Brain diseases -- Analysis, Health, Psychology and mental health
Published
2005

8. The Sardinia Radio Telescope . From a technological project to a radio observatory

Author

G. Serra, G. Valente, Elise Egron, M. Buttu, Federica Govoni, Maura Pilia, I. Prandoni, F. T. Nasir, A. Orlati, Alessio Trois, Andrea Tarchi, A. Pellizzoni, Roberto Ricci, C. Stanghellini, Matteo Murgia, S. Casu, Valentina Vacca, Gianni Comoretto, M. N. Iacolina, F. Loi, N. D'Amico, A. Orfei, Delphine Perrodin, Sergio Poppi, Francesco Gaudiomonte, Tonino Pisanu, Paola Castangia, Pietro Bolli, Raimondo Concu, S. Loru, Marco Bartolini, Alessandro Corongiu, Andrea Melis, Caterina Tiburzi, A. Fara, Alessandro Ridolfi, S. Righini, Matteo Bachetti, Ettore Carretti, F. Massi, C. Migoni, M. Burgay, D. Guidetti, A. Zanichelli, Steven Tingay, I. Porceddu, ITA, and AUS

Subjects
European VLBI Network, 010308 nuclear & particles physics, business.industry, Computer science, FOS: Physical sciences, Astronomy and Astrophysics, First light, Active surface, 01 natural sciences, Sextant (astronomical), law.invention, Radio telescope, Telescope, Pulsar, Space and Planetary Science, law, 0103 physical sciences, Instrumentation (computer programming), Telecommunications, business, Astrophysics - Instrumentation and Methods for Astrophysics, Instrumentation and Methods for Astrophysics (astro-ph.IM), 010303 astronomy & astrophysics
Abstract

[Abridged] The Sardinia Radio Telescope (SRT) is the new 64-m dish operated by INAF (Italy). Its active surface will allow us to observe at frequencies of up to 116 GHz. At the moment, three receivers, one per focal position, have been installed and tested. The SRT was officially opened in October 2013, upon completion of its technical commissioning phase. In this paper, we provide an overview of the main science drivers for the SRT, describe the main outcomes from the scientific commissioning of the telescope, and discuss a set of observations demonstrating the SRT's scientific capabilities. One of the main objectives of scientific commissioning was the identification of deficiencies in the instrumentation and/or in the telescope sub-systems for further optimization. As a result, the overall telescope performance has been significantly improved. As part of the scientific commissioning activities, different observing modes were tested and validated, and first astronomical observations were carried out to demonstrate the science capabilities of the SRT. In addition, we developed astronomer-oriented software tools, to support future observers on-site. The astronomical validation activities were prioritized based on technical readiness and scientific impact. The highest priority was to make the SRT available for joint observations as part of European networks. As a result, the SRT started to participate (in shared-risk mode) in EVN (European VLBI Network) and LEAP (Large European Array for Pulsars) observing sessions in early 2014. The validation of single-dish operations for the suite of SRT first light receivers and backends continued in the following years, and was concluded with the first call for shared-risk/early-science observations issued at the end of 2015., 26 pages, 18 figures, accepted for publication in Section 13 'Astronomical instrumentation' of Astronomy & Astrophysics

Published
2017

9. The eMERGE Survey - I: Very Large Array 5.5 GHz observations of the GOODS-North Field

Author

Ian Smail, M. Bondi, Alasdair Thomson, Robert Beswick, I. M. McHardy, Megan Argo, Jack Radcliffe, Nicholas Wrigley, D. Guidetti, T. W. B. Muxlow, Isabella Prandoni, and Astronomy

Subjects
ACTIVE GALACTIC NUCLEI, Active galactic nucleus, Hubble Deep Field, DEEP FIELD, Astrophysics::High Energy Astrophysical Phenomena, galaxies: active, FOS: Physical sciences, Flux, galaxies: starburst, Astrophysics, F500, Astrophysics::Cosmology and Extragalactic Astrophysics, 01 natural sciences, Jansky, SUPERMASSIVE BLACK-HOLES, 0103 physical sciences, OPTICAL IDENTIFICATIONS, 010303 astronomy & astrophysics, Astrophysics::Galaxy Astrophysics, Physics, radio continuum: galaxies, Supermassive black hole, 010308 nuclear & particles physics, HUBBLE-DEEP, Astronomy, Astronomy and Astrophysics, STAR-FORMATION HISTORY, Astrophysics - Astrophysics of Galaxies, Redshift, Galaxy, ADVECTION-DOMINATED ACCRETION, SPECTRAL ENERGY-DISTRIBUTION, Space and Planetary Science, Astrophysics of Galaxies (astro-ph.GA), cosmology: observations, RADIO-EMISSION, X-RAY, Spectral energy distribution, galaxies: evolution
Abstract

We present new observations of the GOODS-N field obtained at 5.5 GHz with the Karl G. Jansky Very Large Array (VLA). The central region of the field was imaged to a median r.m.s. of 3 microJy/beam with a resolution of 0.5 arcsec. From a 14-arcmin diameter region we extracted a sample of 94 radio sources with signal-to-noise ratio greater than 5. Near-IR identifications are available for about 88 percent of the radio sources. We used different multi-band diagnostics to separate active galactic nuclei (AGN), both radiatively efficient and inefficient, from star-forming galaxies. From our analysis, we find that about 80 percent of our radio-selected sample is AGN-dominated, with the fraction raising to 92 percent when considering only the radio sources with redshift >1.5. This large fraction of AGN-dominated radio sources at very low flux densities (the median flux density at 5.5 GHz is 42 microJy), where star-forming galaxies are expected to dominate, is somewhat surprising and at odds with other results. Our interpretation is that both the frequency and angular resolution of our radio observations strongly select against radio sources whose brightness distribution is diffuse on scale of several kpc. Indeed, we find that the median angular sizes of the AGN-dominated sources is around 0.2-0.3 arcsec against 0.8 arcsec for star-forming galaxies. This highlights the key role that high frequency radio observations can play in pinpointing AGN-driven radio emission at microJy levels. This work is part of the eMERGE legacy project., 18 pages, 11 figures. Online material (table 1, table 4 and appendix) available in the source file. Accepted for publication in MNRAS

Published
2017

10. Dynamic pattern of clinical and MRI findings in a tumefactive demyelinating lesion: a case report

Author

Paolo Immovilli, Vittorio Martinelli, G. Comi, Mauro Comola, Marta Radaelli, D. Guidetti, Paolo Preziosa, Lucia Moiola, Simonetta Gerevini, Emanuele Michieletti, Massimo Filippi, Maria A. Rocca, P. Scagnelli, Preziosa, P, Martinelli, V, Moiola, L, Radaelli, M, Gerevini, S, Guidetti, D, Immovilli, P, Michieletti, E, Scagnelli, P, Comola, M, Rocca, Ma, Filippi, M, and Comi, G

Subjects
Pathology, medicine.medical_specialty, medicine.diagnostic_test, business.industry, Multiple sclerosis, Magnetic resonance imaging, medicine.disease, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Text mining, Neurology, Tumefactive demyelination, Medicine, Dynamic pattern, Neurology (clinical), business, 030217 neurology & neurosurgery, Mri findings
Published
2016

11. Cerebrospinal fluid amounts of HLA-G in dimeric form are strongly associated to patients with MRI inactive multiple sclerosis

Author

Anna Maria Simone, John Charles Rotondo, Ilaria Pesci, Sara Montepietra, Silvia Bolzani, ML Caniatti, Massimo Negrini, S Gutman, Eleonora Baldi, Elisa Mazzoni, Silvia Sabbioni, A. Baruzzi, S Stecchi, Manuela Ferracin, G Terzano, Carlo Contini, M. Pasquinelli, R Rizzo, Roberta Rizzo, L Fiorani, Mauro Gentile, Francesca Vitetta, C Monaldini, E Granieri, Angelica Guareschi, Fernanda Martini, Norina Marcello, Roberto Michelucci, Flavia Salvi, Luisa Motti, E Groppo, Carmine Tamborino, W. Neri, I Casetta, M. Galeotti, Mario Santangelo, C Scandellari, Roberta Bedin, Daria Bortolotti, Silvia Pietrobon, I Masini, E Fainardi, E Baldi, Alessandro Ravasio, Elena Miotto, Patrizia Sola, Diana Ferraro, Valentina Gentili, F. Rasi, S. Malagù, D Bortolotti, Tiziana Antonelli, Franco Granella, Alessandro Trentini, Massimiliano Castellazzi, Paolo Frigio Nichelli, Roberto D'Alessandro, D. Guidetti, Enrico Granieri, Antonella Rotola, M Spadoni, AM Mauro, Franco Dallocchio, Enrico Fainardi, Paolo Immovilli, Tiziana Bellini, Enrico Montanari, Mauro Tognon, S. Seraceni, M Castellazzi, Manfrinato, Maria Luisa Caniatti, Dario Di Luca, S. Ceruti, Gloria Roversi, G. Greco, and Ilaria Casetta

Subjects
0301 basic medicine, Male, Pathology, HLA-G, Relapsing-Remitting, Pathogenesis, 0302 clinical medicine, Cerebrospinal fluid, dimeric form, medicine.diagnostic_test, Blotting, Brain, Middle Aged, Magnetic Resonance Imaging, Spinal Cord, Neurology, Female, MRI activity, medicine.symptom, Western, Dimerization, Adult, medicine.medical_specialty, Multiple Sclerosis, Blotting, Western, Inflammation, Human leukocyte antigen, CSF levels, NO, 03 medical and health sciences, Multiple Sclerosis, Relapsing-Remitting, Western blot, medicine, Humans, HLA-G Antigens, business.industry, Multiple sclerosis, Case-Control Studies, Nervous System Diseases, Neurology (clinical), Magnetic resonance imaging, medicine.disease, 030104 developmental biology, business, 030217 neurology & neurosurgery
Abstract

Background: The relevance of human leukocyte antigen (HLA)-G in dimeric form in multiple sclerosis (MS) is still unknown. Objective: To investigate the contribution of cerebrospinal fluid (CSF) HLA-G dimers in MS pathogenesis. Methods: CSF amounts of 78-kDa HLA-G dimers were measured by western blot analysis in 80 MS relapsing–remitting MS (RRMS) patients and in 81 inflammatory and 70 non-inflammatory controls. Results: CSF amounts of 78kDa HLA-G dimers were more frequent in RRMS than in inflammatory ( pConclusion: Our findings suggest that HLA-G dimers may be implicated in termination of inflammatory response occurring in MS.

Published
2016

12. The magnetized medium around the radio galaxy B2 0755+37: an interaction with the intragroup gas

Author

Judith H. Croston, P. Parma, Robert Laing, D. Guidetti, and Alan H. Bridle

Subjects
Physics, Jet (fluid), Radio galaxy, Astrophysics::High Energy Astrophysical Phenomena, Astronomy and Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, Astrophysics, Rotation, Power law, Spectral line, law.invention, Magnetic field, symbols.namesake, Space and Planetary Science, law, Faraday effect, symbols, Faraday cage
Abstract

We explore the magneto-ionic environment of the isolated radio galaxy B2 0755+37 using detailed imaging of the distributions of Faraday rotation and depolarization over the radio source from Very Large Array observations at 1385,1465 and 4860 MHz and new X-ray data from XMM-Newton. The Rotation Measure (RM) distribution is complex, with evidence for anisotropic fluctuations in two regions. The approaching lobe shows low and uniform RM in an unusual `stripe' along an extension of the jet axis and a linear gradient transverse to this axis over its Northern half. The leading edge of the receding lobe shows arc-like RM structures with sign reversals. Elsewhere, the RM structures are reasonably isotropic. The RM power spectra are well described by cut-off power laws with slopes ranging from 2.1 to 3.2 in different sub-regions. The corresponding magnetic-field autocorrelation lengths, where well-determined, range from 0.25 to 1.4 kpc. It is likely that the fluctuations are mostly produced by compressed gas and field around the leading edges of the lobes. We identify areas of high depolarization around the jets and inner lobes. These could be produced by dense gas immediately surrounding the radio emission containing a magnetic field which is tangled on small scales. We also identify four ways in which the well known depolarization (Faraday depth) asymmetry between jetted and counter-jetted lobes of extended radio sources can be modified by interactions with the surrounding medium.

Published
2012

13. Deep imaging of Fanaroff-Riley Class I radio galaxies with lobes

Author

Alan H. Bridle, R. A. Laing, D. Guidetti, M. Bondi, and P. Parma

Subjects
Physics, Brightness, Jet (fluid), Spectral index, Radio galaxy, Astrophysics::High Energy Astrophysical Phenomena, Astronomy and Astrophysics, Class (philosophy), Astrophysics::Cosmology and Extragalactic Astrophysics, Astrophysics, Collimated light, Lobe, medicine.anatomical_structure, Space and Planetary Science, medicine, Degree of polarization, Astrophysics::Galaxy Astrophysics
Abstract

We present deep, high-resolution imaging of the nearby Fanaroff-Riley Class I (FR I) radio galaxies NGC 193, B2 0206+35, B2 0755+37 and M 84 at frequencies of 4.9 and 1.4 GHz using new and archival multi-configuration observations from the Very Large Array. In addition, we describe lower-resolution observations of B2 0326+39 and a reanalysis of our published images of 3C 296. All of these radio galaxies show twin jets and well-defined lobes or bridges of emission, and we examine the common properties of this class of source. We show detailed images of total intensity, brightness gradient, spectral index, degree of polarization and projected magnetic-field direction. The jet bases are very similar to those in tailed twin-jet sources and show the characteristics of decelerating, relativistic flows. Except on one side of M 84, we find that the jets can be traced at least as far as the ends of the lobes, where they often form structures which we call "caps" with sharp outer brightness gradients. Continuing, but less well collimated flows back into the lobes from the caps can often be identified by their relatively flat spectral indices. The lobes in these radio galaxies are similar in morphology, spectral-index distribution and magnetic-field structure to those in more powerful (FR II) sources, but lack hot-spots or other evidence for strong shocks at the ends of the jets. M 84 may be an intermediate case between lobed and tailed sources, in which one jet does not reach the end of its lobe, but disrupts to form a "bubble".

Published
2011

14. Ordered magnetic fields around radio galaxies: evidence for interaction with the environment

Author

R. A. Laing, P. Parma, Alan H. Bridle, L. Gregorini, and D. Guidetti

Subjects
Physics, Radio galaxy, Field line, Astrophysics::High Energy Astrophysical Phenomena, Astronomy and Astrophysics, Field strength, Astrophysics::Cosmology and Extragalactic Astrophysics, Astrophysics, Rotation, Magnetic field, symbols.namesake, Space and Planetary Science, Orientation (geometry), Faraday effect, symbols, Surface brightness
Abstract

We present detailed imaging of Faraday rotation and depolarization for the radio galaxies 0206+35, 3C 270, 3C 353 and M 84, based on Very Large Array observations at multiple frequencies in the range 1365 to 8440 MHz. This work suggests a more complex picture of the magneto-ionic environments of radio galaxies than was apparent from earlier work. All of the sources show spectacular banded rotation measure (RM) structures with contours of constant RM perpendicular to the major axes of their radio lobes. We give a comprehensive description of the banded RM phenomenon and present an initial attempt to interpret it as a consequence of interactions between the sources and their surroundings. We show that the material responsible for the Faraday rotation is in front of the radio emission and that the bands are likely to be caused by magnetized plasma which has been compressed by the expanding radio lobes. A two-dimensional magnetic structure in which the field lines are a family of ellipses draped around the leading edge of the lobe can produce RM bands in the correct orientation for any source orientation. We also report the first detections of rims of high depolarization at the edges of the inner radio lobes of M 84 and 3C 270. These are spatially coincident with shells of enhanced X-ray surface brightness, in which both the field strength and the thermal gas density are likely to be increased by compression.

Published
2011

15. The 'Vexata Quaestio' on Lacunar Stroke: The Role of CT Perfusion Imaging

Author

Nicola Morelli, D. Guidetti, Emanuele Michieletti, and Eugenia Rota

Subjects
medicine.medical_specialty, Lacunar stroke, Perfusion Imaging, Perfusion scanning, Article, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, X ray computed, medicine, Humans, Radiology, Nuclear Medicine and imaging, cardiovascular diseases, Stroke, medicine.diagnostic_test, business.industry, medicine.disease, Cerebral Angiography, nervous system diseases, body regions, Lacunar Infarcts, Stroke, Lacunar, Neurology (clinical), Radiology, Tomography, X-Ray Computed, business, Nuclear medicine, 030217 neurology & neurosurgery, Cerebral angiography
Abstract

We read with great interest the study of Benson et al,[1][1] which demonstrates that CT perfusion has low sensitivity and high specificity in identifying lacunar infarcts. However, we believe that some clarification on the topic might be useful. Lacunar infarcts are defined as small subcortical

Published
2016

16. Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy

Author

B Casali, M. T. Dotti, D Guidetti, and Rosalucia Mazzei

Subjects
Pathology, medicine.medical_specialty, Receptors, Notch, Physiology, business.industry, CADASIL, Cerebral Infarction, DNA, General Medicine, Prognosis, medicine.disease, Magnetic Resonance Imaging, Diagnosis, Differential, Leukoencephalopathy, Dementia, Multi-Infarct, Dna genetics, Mutation, Prevalence, Internal Medicine, medicine, Humans, business, Receptor, Notch3
Abstract

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an inherited autosomal dominant condition characterized by migrane, recurrent stroke, subcortical dementia, and pseudobulbar palsy. It begins with migraine with aura in -33% of patients. CADASIL is commonly overlooked or misdiagnosed owing to its recent identification. The pathological hallmark of angiopathy is the presence of multiple, small, deep cerebral infarcts, leucoencephalopathy, and nonatherorosclerotic, nonamyloid angiopathy involving mainly small, deep perforating cerebral arteries. Changes also are present in vascular smooth muscle cells and consist in the presence of granular osmiophilic material (GOM). The defective gene in CADASIL is Notch 3, which encodes a large transmembrane receptor. Magnetic resonance imaging shows high intensity signal lesions, often confluent, and areas of cystic degeneration of subcortical white matter and basal ganglia. Diagnostic strategies in CADASIL are matter of discussions because the electron microscopic demonstration of GOM was reported in 100% of symptomatic patients of French authors, but only in 45% of a British study. GOMs are not present in presymptomatic patients.

Published
2006

17. Some results on the identification of memory kernels

Author

F. Colombo, D. Guidetti, M. RUZHANSKY, J. WIRTH, F. Colombo, and D. Guidetti

Subjects
Sobolev space, Identification (information), Quantitative Biology::Neurons and Cognition, Mathematical analysis, DETERMINATION OF CONVOLUTION KERNELS, Applied mathematics, Heat equation, Uniqueness, Inverse problem, Base (topology), INVERSE PROBLEMS, Mathematics, Convolution
Abstract

The present paper is base on a talk given by one of the authors to the 7th International ISAAC Congress held in London, UK, in 2009. A few years ago the authors have introduced a strategy to prove global in time existence and uniqueness results for semilinear integrodifferential inverse problems. Here we discuss the strategies used to treat some problems related to the identification of convolution memory kernels in semilinear integrodifferential models. Moreover, we explain the novelty with respect to some of the existing methods with respect to our strategy whose main ideas are contained in the paper [F. Colombo, D. Guidetti, A global in time existence and uniqueness result for a semilinear integrodifferential parabolic inverse problem in Sobolev Spaces, Math. Models Methods Appl. Sci., 17 (2007), 1–29].Convolution kernels are important to take into account memory effects, but in the case of the heat equation they are also used to make the speed of propagation of the heat finite. Among the models we discuss in this paper we mention: Phase-field models with memory, the heat equation with memory, a model in the theory of combustion, the beam equation with memory and a model arising in the theory of nuclear reactors.

Published
2011

18. Structure of the magneto-ionic media around the FR Class I radio galaxy 3C 449

Author

D. Guidetti, R. A. Laing, M. Murgia, F. Govoni, P. Parma, L. Gregorini, L. Feretti, A. Comastri, L. Angelini, M. Cappi, COMASTRI A., ANGELINI L., CAPPI M., D. Guidetti, R. A. Laing, M. Murgia, F. Govoni, P. Parma, L. Gregorini, and L. Feretti

Subjects
Physics, Radio galaxy, Astronomy, Type-cD galaxy, Astrophysics, Galaxy merger, Disc galaxy, Galaxy, GALAXIES, MAGNETIC FIELD EFFECTS, X-shaped radio galaxy, Interacting galaxy, BRIGHTNESS, Lenticular galaxy, INTERSTELLAR MATTER
Abstract

The goal of this work is to constrain the strength and structure of the magnetic field associated with the environment of the radio source 3C 449 by using observations of Faraday rotation, which we model with a structure function technique, and by comparison with numerical simulations. We present detailed rotation measure images for the polarized radio source 3C 449. All of the observations are consistent with pure foreground Faraday rotation. We also use depolarization measurements to estimate the minimum scale of the field variations. We then develop three-dimensional models with a gas density distribution derived from X-ray observations and a random magnetic field with this power spectrum. The rotation measure and depolarization data are consistent with a broken power-law magnetic-field power spectrum, with a break at about 11 kpc and slopes of 2.98 and 2.07 at smaller and larger scales respectively. The maximum and minimum scales of the fluctuations are ≈65 and ≈0.2 kpc, respectively. The average magnetic field strength at the cluster centre is 3.5 ± 1.2 μG, decreasing linearly with the gas density within ≈16 kpc of the nucleus. At larger distances, the dependence of field on density appears to flatten, but this may be an effect of errors in the density model. The magnetic field is not energetically important.

Published
2010

19. Novel heteroplasmic mtDNA mutation in a family with heterogeneous clinical presentations

Author

Franco Carrara, Marilena Greco, Alessandro Agostino, Massimo Zeviani, D. Guidetti, P. Corona, Eleonora Lamantea, MariaTeresa Dotti, and Caterina Mariotti

Subjects
Adult, Male, Proband, congenital, hereditary, and neonatal diseases and abnormalities, Mitochondrial DNA, Pathology, medicine.medical_specialty, Ataxia, Mitochondrial disease, Respiratory chain, Deafness, DNA, Mitochondrial, Muscular Dystrophies, Ophthalmoparesis, Electron Transport, Paraparesis, Diabetes Mellitus, medicine, Humans, Point Mutation, Muscle, Skeletal, Family Health, Genetics, Muscle biopsy, medicine.diagnostic_test, business.industry, DNA, Skeletal, medicine.disease, Heteroplasmy, Mitochondrial, Pedigree, Diabetes Mellitus, Type 2, Amino Acid Substitution, Neurology, Spastic, Paraparesis, Spastic, Muscle, Nucleic Acid Conformation, Female, Neurology (clinical), medicine.symptom, Cardiomyopathies, business, Type 2
Abstract

The protean manifestations of a novel maternally inherited point mutation of the mitochondrial genome are reported. The proband showed isolated, spastic paraparesis. A brother, who had suffered from a multisystem progressive disorder, ultimately died of cardiomyopathy. Another brother is healthy. The proband's mother showed truncal ataxia, dysarthria, severe hearing loss, mental regression, ptosis, ophthalmoparesis, distal cyclones, and diabetes mellitus. A muscle biopsy performed in the proband failed to show the morphological abnormalities typical of mitochondrial disorders; the activities of respiratory chain complexes were normal. However, complex I and IV activities were low in the muscle homogenate of the affected mother and brother. Sequence analysis of mtDNA showed a heteroplasmic mutation of the tRNA(Ile) gene (G4284A). The mutation load was approximately 55%, 80%, and 90% in the muscle mtDNA of the proband, his mother, and his affected brother, respectively. Mutation was undetected in the healthy brother, as well as in 100 control samples. Several cybrid clones containing homoplasmic mutant mtDNA from the proband showed significant reductions of complex IV activity and maximum oxygen consumption rate, compared with homoplasmic wild-type clones derived from the same subject.

Published
2002

20. Pattern of care and effectiveness of treatment for glioblastoma patients in the real world: Results from a prospective population-based registry. Could survival differ in a high-volume center?

Author

Alba A. Brandes, Enrico Franceschi, Mario Ermani, Alicia Tosoni, Fiorenzo Albani, Roberta Depenni, Marina Faedi, Anna Pisanello, Girolamo Crisi, Benedetta Urbini, Claudio Dazzi, Luigi Cavanna, Claudia Mucciarini, Giuseppe Pasini, Stefania Bartolini, Gianluca Marucci, Luca Morandi, Elena Zunarelli, Serenella Cerasoli, Giorgio Gardini, Giovanni Lanza, Enrico Maria Silini, Silvio Cavuto, Agostino Baruzzi, A. Baruzzi, F. Albani, F. Calbucci, R. D'Alessandro, R. Michelucci, A. Brandes, V. Eusebi, S. Ceruti, E. Fainardi, R. Tamarozzi, E. Emiliani, M. Cavallo, E. Franceschi, A. Tosoni, F. Fiorica, A. Valentini, R. Depenni, C. Mucciarini, G. Crisi, E. Sasso, C. Biasini, L. Cavanna, D. Guidetti, N. Marcello, A. Pisanello, A.M. Cremonini, G. Guiducci, S. de Pasqua, S. Testoni, R. Agati, G. Ambrosetto, A. Bacci, E. Baldin, A. Baldrati, E. Barbieri, S. Bartolini, E. Bellavista, F. Bisulli, E. Bonora, F. Bunkheila, V. Carelli, M. Crisci, P. Dall'Occa, D. de Biase, S. Ferro, C. Franceschi, G. Frezza, V. Grasso, M. Leonardi, G. Marucci, V. Mazzocchi, L. Morandi, B. Mostacci, G. Palandri, E. Pasini, M. Pastore Trossello, A. Pession, M. Ragazzi, P. Riguzzi, R. Rinaldi, S. Rizzi, G. Romeo, F. Spagnolli, P. Tinuper, C. Trocino, S. Cerasoli, M. Dall'Agata, M. Faedi, M. Frattarelli, G. Gentili, A. Giovannini, P. Iorio, U. Pasquini, G. Galletti, C. Guidi, W. Neri, A. Patuelli, S. Strumia, M. Casmiro, A. Gamboni, F. Rasi, G. Cruciani, P. Cenni, C. Dazzi, AR. Guidi, F. Zumaglini, A. Amadori, G. Pasini, M. Pasquinelli, E. Pasquini, A. Polselli, A. Ravasio, B. Viti, M. Sintini, A. Ariatti, F. Bertolini, G. Bigliardi, P. Carpeggiani, F. Cavalleri, S. Meletti, P. Nichelli, E. Pettorelli, G. Pinna, E. Zunarelli, F. Artioli, I. Bernardini, M. Costa, G. Greco, R. Guerzoni, C. Stucchi, C. Iaccarino, R. Rizzi, G. Zuccoli, P. Api, F. Cartei, E. Fallica, E. Granieri, F. Latini, G. Lelli, C. Monetti, V. Ramponi, A. Saletti, R. Schivalocchi, S. Seraceni, M.R. Tola, B. Urbini, C. Giorgi, E. Montanari, D. Cerasti, P. Crafa, I. Dascola, I. Florindo, S. Mazza, F. Servadei, EM. Silini, P. Torelli, P. Immovilli, N. Morelli, C. Vanzo, Brandes, Alba A, Franceschi, Enrico, Ermani, Mario, Tosoni, Alicia, Albani, Fiorenzo, Depenni, Roberta, Faedi, Marina, Pisanello, Anna, Crisi, Girolamo, Urbini, Benedetta, Dazzi, Claudio, Cavanna, Luigi, Mucciarini, Claudia, Pasini, Giuseppe, Bartolini, Stefania, Marucci, Gianluca, Morandi, Luca, Zunarelli, Elena, Cerasoli, Serenella, Gardini, Giorgio, Lanza, Giovanni, Silini, Enrico Maria, Cavuto, Silvio, Baruzzi, Agostino, Calbucci, F, D'Alessandro, R, Michelucci, R, Eusebi, V, Ceruti, S, Fainardi, E, Tamarozzi, R, Emiliani, E, Cavallo, M, Fiorica, F, Valentini, A, Depenni, R, Mucciarini, C, Crisi, G, Sasso, E, Biasini, C, Cavanna, L, Guidetti, D, Marcello, N, Pisanello, A, Cremonini, A M, Guiducci, G, de Pasqua, S, Testoni, S, Agati, R, Ambrosetto, G, Bacci, A, Baldin, E, Baldrati, A, Barbieri, E, Bartolini, S, Bellavista, E, Bisulli, F, Bonora, E, Bunkheila, F, Carelli, V, Crisci, M, Dall'Occa, P, de Biase, D, Ferro, S, Franceschi, C, Frezza, G, Grasso, V, Leonardi, M, Marucci, G, Mazzocchi, V, Morandi, L, Mostacci, B, Palandri, G, Pasini, E, Pastore Trossello, M, Pession, A, Ragazzi, M, Riguzzi, P, Rinaldi, R, Rizzi, S, Romeo, G, Spagnolli, F, Tinuper, P, Trocino, C, Cerasoli, S, Dall'Agata, M, Faedi, M, Frattarelli, M, Gentili, G, Giovannini, A, Iorio, P, Pasquini, U, Galletti, G, Guidi, C, Neri, W, Patuelli, A, Strumia, S, Casmiro, M, Gamboni, A, Rasi, F, Cruciani, G, Cenni, P, Dazzi, C, Guidi, Ar, Zumaglini, F, Amadori, A, Pasini, G, Pasquinelli, M, Pasquini, E, Polselli, A, Ravasio, A, Viti, B, Sintini, M, Ariatti, A, Bertolini, F, Bigliardi, G, Carpeggiani, P, Cavalleri, F, Meletti, S, Nichelli, P, Pettorelli, E, Pinna, G, Zunarelli, E, Artioli, F, Bernardini, I, Costa, M, Greco, G, Guerzoni, R, Stucchi, C, Iaccarino, C, Rizzi, R, Zuccoli, G, Api, P, Cartei, F, Fallica, E, Granieri, E, Latini, F, Lelli, G, Monetti, C, Ramponi, V, Saletti, A, Schivalocchi, R, Seraceni, S, Tola, M R, Urbini, B, Giorgi, C, Montanari, E, Cerasti, D, Crafa, P, Dascola, I, Florindo, I, Mazza, S, Servadei, F, Silini, Em, Torelli, P, Immovilli, P, Morelli, N, and Vanzo, C

Subjects
Oncology, medicine.medical_specialty, medicine.medical_treatment, Population, Medicine (miscellaneous), temozolomide, NO, surgery, center volume, glioblastoma, radiotherapy, Internal medicine, Glioma, medicine, education, Prospective cohort study, education.field_of_study, Temozolomide, Neurologic Oncology, business.industry, Incidence (epidemiology), Articles, medicine.disease, nervous system diseases, Clinical trial, Radiation therapy, business, medicine.drug
Abstract

Background As yet, no population-based prospective studies have been conducted to investigate the incidence and clinical outcome of glioblastoma (GBM) or the diffusion and impact of the current standard therapeutic approach in newly diagnosed patients younger than aged 70 years. Methods Data on all new cases of primary brain tumors observed from January 1, 2009, to December 31, 2010, in adults residing within the Emilia-Romagna region were recorded in a prospective registry in the Project of Emilia Romagna on Neuro-Oncology (PERNO). Based on the data from this registry, a prospective evaluation was made of the treatment efficacy and outcome in GBM patients. Results Two hundred sixty-seven GBM patients (median age, 64 y; range, 29–84 y) were enrolled. The median overall survival (OS) was 10.7 months (95% CI, 9.2–12.4). The 139 patients ≤aged 70 years who were given standard temozolomide treatment concomitant with and adjuvant to radiotherapy had a median OS of 16.4 months (95% CI, 14.0–18.5). With multivariate analysis, OS correlated significantly with KPS (HR = 0.458; 95% CI, 0.248–0.847; P = .0127), MGMT methylation status (HR = 0.612; 95% CI, 0.388–0.966; P = .0350), and treatment received in a high versus low-volume center (HR = 0.56; 95% CI, 0.328–0.986; P = .0446). Conclusions The median OS following standard temozolomide treatment concurrent with and adjuvant to radiotherapy given to (72.8% of) patients aged ≤70 years is consistent with findings reported from randomized phase III trials. The volume and expertise of the treatment center should be further investigated as a prognostic factor.

Published
2014

21. Spontaneous carotid dissection presenting lower cranial nerve palsies

Author

D. Guidetti, Claudio Morandi, Franco Giovanardi, Giulio Zuccoli, Anna Pisanello, and Troiso A

Subjects
Adult, medicine.medical_specialty, Palsy, Accessory nerve, business.industry, Carotid Artery, Internal, Dissection, Middle Aged, medicine.disease, Cranial Nerve Diseases, Surgery, Paresis, Carotid artery dissection, Hemiparesis, Neurology, medicine.artery, Spinal nerve, medicine, Paralysis, Humans, Female, Neurology (clinical), medicine.symptom, Internal carotid artery, business, Hypoglossal nerve
Abstract

Cranial nerve palsy in internal carotid artery (ICA) dissection occurs in 3--12% of all patients, but in 3% of these a syndrome of hemicranias and ipsilateral cranial nerve palsy is the sole manifestation of ICA dissection, and in 0.5% of cases there is only cranial nerve palsy without headache. We present two cases of lower cranial nerve palsy. The first patient, a 49-year-old woman, developed left eleventh and twelfth cranial nerve palsies and ipsilateral neck pain. The angio-RM showed an ICA dissection with stenosis of 50%, beginning about 2 cm before the carotid channel. The patient was treated with oral anticoagulant therapy and gradually improved, until complete clinical recovery. The second patient, a 38-year-old woman, presented right hemiparesis and neck pain. The left ICA dissection, beginning 2 cm distal to the bulb, was shown by ultrasound scanning of the carotid and confirmed by MR angiogram and angiography with lumen stenosis of 90%. Following hospitalisation, 20 days from the onset of symptoms, paresis of the left trapezius and sternocleidomastoideus muscles became evident. The patient was treated with oral anticoagulant therapy and only a slight right arm paresis was present at 10 months follow-up. Cranial nerve palsy is not rare in ICA dissection, and the lower cranial nerve palsies in various combinations constitute the main syndrome, but in most cases these are present with the motor or sensory deficit due to cerebral ischemia, along with headache or Horner's syndrome. In the diagnosis of the first case, there was further difficulty because the cranial nerve palsy was isolated without hemiparesis, and the second case presented a rare association of hemiparesis and palsy of the eleventh cranial nerve alone. Compression or stretching of the nerve by the expanded artery may explain the palsies, but an alternative cause is also possible, namely the interruption of the nutrient vessels supplying the nerve, which in our patients is more likely.

Published
2001

22. [Untitled]

Author

A. Ferlini, D. Guidetti, I. Torrente, and R. Sabadini

Subjects
medicine.medical_specialty, Pediatrics, Epidemiology, business.industry, Mortality rate, Incidence (epidemiology), Prevalence, Spinal muscular atrophy, Progressive bulbar palsy, medicine.disease, Surgery, medicine, Amyotrophic lateral sclerosis, business, Rare disease
Abstract

Commencing with the work carried out during the epidemiological survey of amyotrophic lateral sclerosis in the period 1980–1992 and the pathology follow-up, we carried out a perspective incidence, prevalence and mortality survey of X-linked bulbar and spinal muscular atrophy (X-BSMA) in the province of Reggio Emilia in Northern Italy. Based on 11 patients (eight familial and three sporadic cases), the mean incidence per year for the period 1980 through 1997, as evaluated at the onset of symptoms, was 0.09 cases/100,000 for the total population and 0.19 cases/100,000 for the male population. On December 31, 1997, the prevalence rate was 1.6/100,000 for the total population and 3.3/100,000 for the male population. In the 18-year period of 1980–1997, the average yearly mortality rate was: 0.03 cases/100,000 per year for the total population and 0.06 cases/100,000 for the male population. The average age at onset was 44.8 ± 10.1, and the average survival period was 27.3 ± 2.3 years. The average age of the prevalence day was 58.9 ± 14.9, and the average age at death was 71.3 ± 4.7 years. Whereas the incidence rate of X-BSMA in the province of Reggio Emilia is 16 times lower that of amyotrophic lateral sclerosis (ALS), the incidence rate of progressive bulbar palsy in the male population is only slightly higher than X-BSMA; and the prevalence rate of ALS for males is two times the prevalence rate for X-BSMA, with overlapping of confidence intervals. X-BSMA is a rare disease, which is probably under-diagnosed, but due to the long survival period of this disease its frequency is not negligible. Because of the presence of sporadic cases or non-evident familial cases, it is appropriate to consider this diagnostic possibility in making a diagnosis of ALS in patients in whom lower motor neuron dysfunction or bulbar onset predominates.

Published
2001

23. [Untitled]

Author

M. Lodesani, Renato Mantegazza, R. Sabadini, D. Guidetti, F. Cosi V e Solime, and S. Cavalletti

Subjects
Malignant Thymoma, medicine.medical_specialty, education.field_of_study, Pediatrics, Thymoma, Epidemiology, business.industry, Incidence (epidemiology), medicine.medical_treatment, Mortality rate, Population, Prevalence, medicine.disease, Myasthenia gravis, Surgery, Thymectomy, Medicine, business, education
Abstract

We carried out a retrospective incidence, prevalence and mortality survey of myasthenia gravis in the province of Reggio Emilia in Northern Italy. Based on 49 patients, the mean incidence per year for the period 1980 through 1994 was 7.8 per 1,000,000. On 31 December 1994 the prevalence rate was 117.5 per 1,000,000 for all patients, either active or recovered (50 cases in a population of 427,493) and 103.4 per 1,000,000 for the active disease. In the 15-year period 1980–1994 the average mortality rate was 1.0 per 1,000,000 per year. The average age at onset was 44.6 ± 21.0, and the average age at the time of prevalence determination was 51.1 ± 19.6 for the active disease. At the time of diagnosis, 21 patients (36.8%) were classed in group I according to Osserman's criteria, 31 in group II (54.4%), (19 in group II-A and 12 in group II-B), and the other 5 (8.8%) in group III. Of all the prevalence cases, 6 (12%) were in remission without therapy and 6 with therapy, while most of the others 16 (32%) were classed in group I, 15 (30%) in group II, and 1 (2%) in group III. Thymectomy was performed in 20 patients (35.1%), 12 (21%) had thymoma (malignant in 4 cases), 6 had thymic hyperplasia while in two patients thymic histology was normal. The relation the grade of Osserman's scale at the time of incidence and the presence of thymoma were significant. Higher grades of Osserman's scale were associated were malignant thymoma. Furthermore the relationship between thymectomy and the grade of Osserman's scale at the date of prevalence was significant for the presence of lower grades of Osserman's scale in the patients submitted to thymectomy.

Published
1998

24. Lead, cadmium, and selenium in the blood of patients with sporadic amyotrophic lateral sclerosis

Author

F. Solimé, M. Olmi, Sergio Rovesti, Margherita Bergomi, D. Guidetti, Marco Vinceti, R. Vivoli, E. Caselgrandi, and L. Rinaldi

Subjects
Male, inorganic chemicals, medicine.medical_specialty, Pathology, Neurology, cadmium, Lead, selenium, blood, sporadic amyotrophic lateral sclerosis, chemistry.chemical_element, Physiology, Dermatology, Selenium, Risk Factors, Humans, Medicine, Amyotrophic lateral sclerosis, Aged, Whole blood, Cadmium, business.industry, General Neuroscience, Amyotrophic Lateral Sclerosis, Case-control study, General Medicine, Middle Aged, medicine.disease, Psychiatry and Mental health, chemistry, Case-Control Studies, Etiology, Population study, Female, Neurology (clinical), business
Abstract

We determined whole blood lead and cadmium levels, and serum selenium levels in patients with sporadic amyotrophic lateral sclerosis and age- and sex-matched controls. Disability due to the disease directly correlated with lead levels, and there was a strong inverse correlation with selenium concentrations. Lead and selenium concentrations tended to be similar in the cases and controls, both in the study population as a whole and after the removal from the analysis of the patients with the highest degree of disability. In the patients with limited disability, cadmium concentrations were higher than in the controls. Our findings lend limited support to a possible involvement of cadmium, but not lead, in the etiology of sporadic amyotrophic lateral sclerosis, and strongly suggest that short-term indicators of exposure are inadequate to investigate the relationship between selenium and the disease.

Published
1997

25. e-MERLIN observations at 5 GHz of the GOODS-N region: pinpointing AGN cores in high redshift galaxies

Author

D. Guidetti, Ian Smail, I. M. McHardy, Nicholas Wrigley, T. W. B. Muxlow, Isabella Prandoni, Robert Beswick, and M. Bondi

Subjects
Active galactic nucleus, Cosmology and Nongalactic Astrophysics (astro-ph.CO), active [Galaxies], Radio galaxy, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, Disc galaxy, 01 natural sciences, 0103 physical sciences, Galaxy formation and evolution, observations [Cosmology], galaxies. [Radio continuum], 010303 astronomy & astrophysics, Astrophysics::Galaxy Astrophysics, Luminous infrared galaxy, Physics, 010308 nuclear & particles physics, Star formation, Astrophysics::Instrumentation and Methods for Astrophysics, Astronomy, Astronomy and Astrophysics, evolution [Galaxies], Redshift, Galaxy, starburst [Galaxies], Space and Planetary Science, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

We present 5 GHz e-MERLIN observations of the GOODS-N region at sub-arcsec resolution (0.2--0.5 arcsec). These data form part of the early commissioning observations for the e-MERLIN interferometer and a pilot for the e-MERLIN legacy program eMERGE. A total of 17 sources were detected with S/N>3. These observations provide unique information on the radio source morphology at sub-arcsec scales. For twelve of these sources, deeper 1.4 GHz MERLIN+VLA observations at the same spatial resolution are available, allowing radio spectral indices to be derived for ten sources on sub-arcsec angular scales. Via analysis of the spectral indices and radio morphologies, these sources have been identified as AGN cores in moderate-to-high redshift (1, Comment: 11 pages, 3 figures, accepted for publication in MNRAS

Published
2013

26. Contents Vol. 15, 1996

Author

Franco Gemignani, Elizabeth J. Cochran, N. Marcello, Yuri Nikitin, R. Sabadini, Gianfranco Vivoli, Adriana Marbini, Parthasarthy Satishchandra, Eric C. Seaberg, A. Freire de Concalves, D.K. Subbakrishna, Juhani Sivenius, Jukka T. Salonen, Philip B. Gorelick, D. Guidetti, Marco Vinceti, A. Colombo, J.T. Tuomilehto, Mandaville Gourie-Devi, Peter J. Koudstaal, D. E. Grobbee, David C. Garron, Milton Alter, Steven H. Belle, F. Solimé, W. Scheuermann, Gopalkrishna Gururaj, David L. Nyenhuis, Lewis H. Kuller, Steven T. DeKosky, A. Trichopoulou, Laurie Mallery, Kenneth Rockwood, L. Amaducci, S. Cavalletti, Paul Stolee, D.S. Thelle, O. Krüger, Graham Ratcliff, Kellee Howard, José M. Ferro, Mary Ganguli, M. Bondavalli, Adriano Ferrari, Michiel L. Bots, Peter Creighton Elwood, and Domenico Inzitari

Subjects
Traditional medicine, Epidemiology, business.industry, Medicine, Neurology (clinical), business
Published
1996

27. Randomised controlled trial of streptokinase, aspirin, and combination of both in treatment of acute ischaemic stroke

Author

F Finzi, G Alunni, G Costantino, E Ghidoni, M Sfrappini, L Roveyaz, M Marra, J Wardlaw, A Ballini, G Lancia, F Zuccari, M Dicostanzo, A Brambilla, E Greco, L Melini, S Terenziani, E Moschini, G Marzara, A Gasparro, G Dalessandro, O Citterio, R Milani, A Pietra, S Comparetti, G Lama, D Sabatini, G Volpi, M Cruciani, L Ralli, A Vinattieri, L Casto, M Rottoli, S Ragaini, S Polonara, M Digiovanni, E Dejuli, G Danieli, P Menegazzo, A Brucato, O Marrazza, A Palumbo, F Costantini, I Laspina, E Righetti, F Deblasi, C Giorgi, G Landini, N Bonasera, L Calvi, A Lorizio, D Vanni, C Delfavero, L Provinciali, R Zucco, U Marini, R Nuzzi, F Cocco, G Crisi, C Defanti, M Porta, M Santangelo, E Pieragnoli, D Belladonna, L Giglia, D Sita, E Cani, V Lolli, S Spolveri, S Ricci, A Perreti, M Rascaroli, P Monaco, G Pisapia, G Candeliere, L Bagnoli, L Bruni, L Curatola, E Decapitani, R Capialbi, P Lattuada, J Bamford, M Poli, G Arena, R Diperri, F Pezzella, A Colombo, F Aloy, S Blanc, M Guidotti, G Baldassarri, A Garagnani, U Loi, C Leviminzi, V Romanazzi, C Sacchet, F Barzizza, V Avenia, M Taglioli, V Pontrelli, M Arnaboldi, G Trianni, F Raudino, A Bettinelli, G Russo, D Belvedere, P Infricciolo, A Paci, E Natali, G Santoro, M Correia, S Pasquali, G Pellegrini, D Mirabile, A Messina, G Alborini, J Bogousslavsky, F Colonna, A Randazzo, F Minotta, F Lincesso, G Degliantoni, T Carboni, A Martelli, A Pirisi, V Miele, P Girardi, C Menozzi, U Scoditti, F Cardopatri, M Santoni, S Gueli, C Scaccabarozzi, A Picchiarelli, M Camerlingo, L Carosella, A Mamoli, F Dacuno, D Tonti, A Troiso, P Piazza, A Castellano, M Veneziani, M Zampolini, S Santini, C Argentino, G Palmieri, G Pinardi, G Bovio, P Sandercock, A Boccali, M Baratti, R Musolino, G Tognoni, A Gatta, E Longhini, L Steidl, G Rosati, M Delgobbo, C Refi, P Panzetti, G Bissi, G Rizzato, M Pratesi, E Bottacchi, L Candelise, G Bollettini, L Fera, P Ottaviano, G Coppola, Vittorio Bertele, M Degiorgi, F Triolo, O Tafani, M Pallone, D Guidetti, N Marcello, C Scarpati, L Desantis, F Rizzitelli, C Conte, M Voloute, G Scialfa, G Lombardo, M Bianchi, G Micili, L Motti, D Bosone, C Fini, C Matacena, F Turiamo, R Luccioli, N Miele, F Rossi, D Gori, C Clarke, T Frattini, M Celani, G Thiella, A Cantini, F Schieroni, O Scarpino, M Masina, P Sorgato, G Capocchi, F Colombo, M Zocchi, I Mazzanti, A Trenta, R Cavestri, R Reginelli, P Bassi, G Grilli, A Fancellu, D Orrico, M Scarpa, M Franceschi, F Passeri, A Ghetti, M Bondi, M Spanu, C Motto, E Negri, M Rezzonico, T Lomuzio, E Pretolani, R Ciola, S Grasselli, G Erli, M Desimoni, D Bertuzzi, H Barnett, A Vemco, G Musco, C Degrandi, A Fennetry, B Censori, A Delfavero, B Biscottini, R Peto, F Federico, C Bonaventi, C Bascelli, G Malferrari, C Alli, D Porazzi, G Sgaroni, A Giannini, G Scarlato, E Boccardi, A Cavallini, R Sterzi, E Aritzu, P Dudine, M Stellio, F Clerici, F Porro, R Grandi, L Munari, M Pacini, S Bartolini, M Zadra, A Balotta, A Sensidoni, B Felice, F Locatelli, W Garuti, R Gobbato, F Solime, L Sallusto, C Warlow, G Pirazzoli, G Ferrarini, M Watt, P Perrone, N Caputo, R Menozzi, M Michelini, R Bellesi, A Lechi, F Marras, I Bartolini, E Pascarelli, I Dascola, G Casu, G Divizia, M Ceravolo, R Ibba, R Insabato, G Venables, I Iori, G Greco, M Deledda, N Bartolini, F Grandi, E Cerioli, S Biagini, G Grampa, P Bannister, F Sasanelli, S Canzi, T Riccardi, A Bartocci, F Basso, A Marceca, C Cappelletti, I Santilli, R Bettini, F Salsa, Maria Carla Roncaglioni, G Bottini, A Ciccone, G Rebucci, A Maggioni, P Marotta, G Iannone, C Longoni, F Milone, V Inchingolo, V Chioma, E Lanza, and R Ferani

Subjects
Aspirin, Randomized controlled trial, law, business.industry, Streptokinase, Anesthesia, Medicine, General Medicine, business, Acute ischemic stroke, law.invention, medicine.drug
Published
1995

28. High dose intravenous immune globulins and plasma exchange in Guillain-Barré Syndrome

Author

V. Lolli, P. Sorgato, Giovanni Pavesi, E. Montanari, Mario Santangelo, Valeria Tugnoli, Luisa Motti, V. Miele, G G Rebucci, Giovanni Ambrosetto, Fabrizio Salvi, W. Neri, F. Rasi, M. Gentilini, Alessandro Ravasio, Maria Guarino, V. Mussuto, V. Poli, I. Allegri, G. Bianchedi, B. Currò Dossi, C. Callegarini, L. Falco, S. Laudadio, M. Pasquinelli, D. Guidetti, G. Tralli, A. Scaglioni, Franco Granella, G. Mazzini, Roberto D'Alessandro, Vittorio Govoni, C. Guidi, R. Fabbri, V. Ferrari, M. Casmiro, A. Colombo, Elisa Merelli, G. Ciucci, AR Guidi, G. Padoan, G. Facchini, R. Baldrati, Tommaso Sacquegna, Enrico Granieri, M. Galeotti, Sergio Cammarata, F. Solimé, and M. Gessaroli

Subjects
medicine.medical_specialty, Neurology, Guillain-Barre syndrome, Globulin, biology, business.industry, General Neuroscience, Clinical course, Disease, medicine.disease, Immune system, Internal medicine, Immunology, biology.protein, Medicine, Neurology (clinical), Neurosurgery, business, Incidence study
Abstract

We report the effects of treatment with plasma-exchange (PE) and intravenous immune globulins (IVIg) in 36 out of 50 patients with Guillain-Barre syndrome (GBS) recruited by an incidence study in the Emilia-Romagna region of Italy. Comparison of the patients treated with PE and IVIg showed no significant differences in terms of effectiveness in improving the clinical course of GBS: at one month, respectively 11.1% and 25% had recovered, and 55.5% and 58.3% had improved by at least one grade. These results are in agreement with those of the Dutch GBS trial. No relapses were observed in either group. Moreover, our results showed no difference in clinical outcome at 1 and 3 months between the patients receiving only one therapy and those receiving two; a second cycle of therapy did not seem to improve the clinical course of the disease significantly. We conclude that PE and IVIg are both safe and effective therapies for GBS.

Published
1995

29. Dystrophin expression in skin biopsy immunohistochemical localisation of striated muscle type dystrophin

Author

N. Marcello, Adriano Ferrari, Franco Gemignani, D. Guidetti, Adriana Marbini, and M. F. Bellanova

Subjects
musculoskeletal diseases, congenital, hereditary, and neonatal diseases and abnormalities, medicine.medical_specialty, mdx mouse, Adolescent, Biopsy, Duchenne muscular dystrophy, Muscular Dystrophies, Dystrophin, Reference Values, Internal medicine, Utrophin, medicine, Humans, Tissue Distribution, Muscular dystrophy, Child, Muscle, Skeletal, Myopathy, Skin, biology, business.industry, Muscle, Smooth, Neuromuscular Diseases, Middle Aged, musculoskeletal system, medicine.disease, Immunohistochemistry, Endocrinology, Neurology, Congenital muscular dystrophy, biology.protein, Neurology (clinical), medicine.symptom, ITGA7, business
Abstract

Dystrophin is normally localized in smooth muscle fibers of various organs in experimental animals, and it has been shown to be defective in the smooth muscle fibers of the mdx mouse, including the myoepithelial cell layer of the sweat glands. We investigated dystrophin localization, using three antisera raised against different domains of skeletal muscle type of dystrophin, in the smooth muscle structures of the skin, using immunohistochemical methods with monoclonal antibodies against dystrophin, in 24 patients with various neuromuscular diseases, and in a normal control. Skin biopsy showed a strong dystrophin reaction in the arrector pili muscles and in the myoepithelial cells of the sweat glands of patients with congenital muscular dystrophy, polymyositis, distal myopathy, putative Duchenne muscular dystrophy carriers, myoglobinuria, neurogenic atrophy and in a normal control. A faint positive dystrophin reaction was seen in four patients with Becker muscular dystrophy, whereas it was absent in 3 patients with Duchenne muscular dystrophy. As our data suggest that immunohistochemical dystrophin expression in smooth muscle structures of the skin is similar to that observed in striated muscle, skin biopsy may represent an alternative way to ascertain dystrophin deficiency.

Published
1995

30. Annual Meeting of the World Federation of Neurology-Research Group on Neuroepidemiology (Part 2 of 2)

Author

N. André, Donald B. Martin, D. Guidetti, S. Cavalletti, P. Zanoni, Juan J. Vílchez, Boleslaw H Liwnicz, Zoreh Davanipour, Patrizia Sola, P. Simonazzi, E. Creisson, Thomas Bohr, E. Merelli, Eugene Sobel, Francesc Palau, Teresa Sevilla, M. Giroud, François Becker, Soomi Chang, H. Fayolle, F. Solimé, Carey Smoak, J.M. López-Arlandis, and R. Dumas

Subjects
medicine.medical_specialty, Neurology, Epidemiology, Group (periodic table), business.industry, Family medicine, medicine, Neuroepidemiology, Neurology (clinical), business
Published
1995

31. Annual Meeting of the World Federation of Neurology-Research Group on Neuroepidemiology (Part 1 of 2)

Author

S. Cavalletti, F. Solimé, R. Dumas, François Becker, Boleslaw H Liwnicz, Zoreh Davanipour, P. Zanoni, Eugene Sobel, Soomi Chang, Donald B. Martin, D. Guidetti, E. Merelli, Teresa Sevilla, Carey Smoak, J.M. López-Arlandis, M. Giroud, Francesc Palau, Patrizia Sola, P. Simonazzi, H. Fayolle, E. Creisson, Juan J. Vílchez, N. André, and Thomas Bohr

Subjects
medicine.medical_specialty, Neurology, Epidemiology, business.industry, 030501 epidemiology, 03 medical and health sciences, 0302 clinical medicine, Group (periodic table), Family medicine, Medicine, Neuroepidemiology, Neurology (clinical), 0305 other medical science, business, 030217 neurology & neurosurgery
Published
1995

32. Fourth meeting of the European Neurological Society 25–29 June 1994 Barcelona, Spain

Author

H. Hattig, C. Delli Pizzi, M. C. Addonizio, Michelle Davis, A. R. Giovagnoli, L. Florensa, M. Roth, J. de Kruijk, Francisco Lacruz, Ph. Dewailly, A. Toygar, C. Avendano, P.P. De Deyn, J. F. Hurtevent, F. Lomeila, T. W. Wong, Gordon T. Plant, M. Bud, H. J. Willison, DH Miller, D. W. Langdon, R. Cioni, J. Servan, A. Kaygisiz, E. Racadot, D. B. Schens, E. Picciola, L. Falip, C. Bouchard, J. Jotova, A. Jorge-Santamaria, P. Misra, A. Dufour, C. P. Panagopoulos, A. Venneri, B. Sredni, B. Angelard, M. Janelidze, M. Carreno, J. Obenberger, J. Pouget, H. W. Moser, R. Kaufmann, J. A. Molina, D. Linden, A. Martin Urda, E. Uvestad, A. Krone, J. P. Cochin, J. Mallecourt, A. Cambon-Thomsen, K. Violleau, P. Osschmann, A. M. Durocher, E. Bussaglia, D. M. Danielle, H. Efendi, C. Van Broeckhoven, K. G. Jordan, W. Rautenberg, C. Iniguez, J. M. Delgado, Graham Watson, M. Lawden, Gareth J. Barker, K. Stiasny, James T. Becker, G. Campanella, E. Peghi, A. Poli, A. Haddad, T. Yamawaki, Giacomo P. Comi, S. Sotgiu, B. Ersmark, A. Pomes, M. Ziegler, P. Ferrante, P. Ruppi, H. KuÇukoglu, R. Bouton, U. K. Rinne, P. Vieregge, M. Dary, P. Giunti, Peter J. Goadsby, S. Jung, E. Secor, A. Steinberg, N. Vila, M. A. Hernandez, M. Cursi, A. Enqelhardt, A. Engelhardt, J. Veitch, F. Di Silverio, F. Arnaud, B. Neundörfer, R. Brucher, Dominique Caparros-Lefebvre, B. Meyer, Marianne Dieterich, M. H. Snidaro, R. Gomez, R. Cerbo, M. Ragno, J. M. Vance, S. Nemni, A. Caliskan, F. Barros, I. Velcheva, D. Ceballos-Baumann, V. Barak, A. Avila, N. Antonova, F. Resche, S. Pappata, L. Varela, S. R. Silveira Santos, A. Cammarota, L. Naccache, Y. Nara, E. Tournier-Lasserves, R. Mobner, T. Chase, A. Ensenyat, J. Ulrich, G. Giegerich, M. Rother, M. Revilla, N. Nitschke, K. Honczarenko, E. Basart Tarrats, J. Blin, B. Jacob, J. Santamaria, S. Knezevic, J. L. Castillo, M. Antem, J. Colomer, O. Busse, Didier Hannequin, S. Carrier, J. B. Ruidavets, C. Rozman, J. Bogoussslavsky, J. Pascual Calvet, E. Monros, J. M. Polo, M. Zucconl, Javier Muruzabal, R. R. Allen, R. Rivolta, K. Haugaard, A. Nespolo, K. Hoang-Xuang, G. Bussone, T. Avramidis, E. Corsini, Christiana Franke, T. Vinogradova, H. Boot, K. Vestergaard, G. H. Jansen, N. Argentino, M. Raltzig, W. Linssen, Mark B. Pepys, P. Roblot, L. Lauritzen, E. Fainardi, D. Morin, T. X. Arbizu Urdiain, J. Wollenhaupt, S. Bostantjopoulou, G. Pavesi, A. D. Forman, Giovanni Fabbrini, D. Jean, J. J. Archelos, M. I. Blanchs, M. Del Gobbo, Anna Carla Turconi, Ch. Derouesné, Elio Scarpini, A. Visbeck, P. Castejon, J. P. Renou, F. Mounier-Vehier, G. Potagas, Ch. Duyckaerts, A. Filla, R. Schneider, G. Ronen, K. Nagata, J. P. Vedel, A. Henneberg, G. van Melle, C. Baratti, H. Knott, M. C. Prevett, A. Bes, B. Metin, Jos V. Reempts, L. Martorell, Mefkure Eraksoy, H. O. Handwerker, D. S. Younger, O. Oktem, D. Frongillo, C. Soriano-Soriano, L. Niehaus, F. Zipp, A. Tartaro, S Newman, R. H. Browne, P. Davous, R. Sanchez, M. Muros, M. E. Kornhuber, A. Lavarone, M. Mohr, M. R. Garcia, S. Russell, H. Kellar-Wood, M. R. Tola, B. Ostermeyer, Ch. Tzekov, K. Sartor, E. B. Ringelstein, P. P. Gazzaniga, Paul Krack, H. Fidaner, H. Rico, T. Dbaiss, F. Alameda, E. Torchiana, L. Rumbach, I. Charques, J. M. Bogaard, C. D. Frith, L. J. Rappelle, R. Brenner, A. Joutel, K. Fuxe, G. HÄcker, M. J. Blaser, J. Valls-SolÇ, G. Ulm, M. Alberdi, A. Bock, F. W. Bertelsmann, U. Wieshmann, J. Visa, J. R. Lupski, D. D'Amico, L. M. P. Ramos, A. A. Vanderbark, R. Horn, M. Warmuth, Dietmar Kühne, Mark S. Palmer, C. Ehrenheim, E. Canga, S. Viola, O. Scarpino, P. Naldi, R. Almeida, A. A. Raymond, J. Gamez, Stephan Arnold, A. DiGiovanni, J. Dalmau, C. C. Chari, H. F. Beer, J. C. Koetsier, J. Iriarte, E. Yunis, J. Casadevall, E. Le Guern, E. Stenager, S. R. Benbadis, J. M. Warter, F. Burklin, I. Theodorou, L. Johannesen, G. A. Graveland, X. Leclerc, I. Vecchio, L. Ozelius, G. Nicoletti, R. K. Gherardi, E. Esperet, M. L. Delodovici, F. Cattin, F. Paiau, Giorgio Sacilotto, C. A. J. Broere, D. Chavdarov, J. P. Willmer, C. H. Hawkes, Th. Naegele, E. Ellie, E. Dartigues, M. J. Guardiola, S. Hesse, Z. Levic, Marco Rovaris, P. Saugeir-Veber, B. A. Yaqub, H. F. Durwen, R. Larumbe, J. Ballabrina, M. Sendtner, J. Röther, M. Horstink, C. Kluglein, M.P. Montesi, H. Apaydin, J. Montoya, E. Waubant, Ch. Verellen-Dunoulin, A. Nicolai, J. Lopez-Delval, R. Lemon, G. Cantinho, E. Granieri, A. Zeviani, Wolfgang H. Oertel, U. Ficola, V. Di Piero, V. Fragola, K. Sabev, M. V. Guitera, I. Turki, F. Bolgert, P. Ingrand, J. M. Gobernado, L. M. E. Grimaldi, S. Baybas, B. Eymard, Y. Rolland, Y. Robitaille, Ta. Pampols, P. J. Koehler, A. Carroacedo, J. Vilchez, S. Di Vittorio, I. R. Rise, T. Nagy, M. Kuffner, E. Palazzini, A. Ott, J. Pruim, T. X. Arbizu, E. Manetti, C. Cervera, S. Felber, G. Gursoy, J. Scholz, G. A. Buscaino, M. S. Chen, A. Pascual, J. Hazan, J. U. Gajda, J. G. Cea, G. Bottini, G. Damalik, F. Le Doze, G. Bonaldi, J. M. Hew, C. Messina, A. M. Kennedy, J. M. Carney, N. M. F. Murray, M. Parent, M. Koepp, V. Dimova, D. De Leo, K. Jellinger, G. Salemi, S. Mientus, M. L. Hansen, F. Mazzucchelli, J. Vieth, M. Mauri, E. Bartels, L. Johannsen, C. Humphreys, J. Emile, D. N. Landon, E. Kansu, R. Sanchez-Pernaute, Rsj Frackowiak, M. Gonzalez Torres, L. Oller, C. Machedo, J. Kother, M. Billiard, H. Durak, T. Schindler, A. Frank, A. Uncini, A. Sbriccoli, C. Farinas, D. W. Paty, N. Fast, A. T. Zangaladze, A. Kerkhofs, J. M. Pino Garcia, I. De la Fuente, B. Marini, L. Gomez, I. Rubio, Alessandra Bardoni, C. Brodie, P. Acin, U. Sliwka, S. A. Hawkins, S. Tardieu, F. Vitullo, J. M. Pereira Monteino, R. Gagliardi, T. Jezewski, A. Cano, T. Lempert, F. Abad Alegria, G. Rotondo, D. Ince, C. Martinez Parra, Y. Huang, H. Luders, Y. Steinvil, F. G. A. Van Der Meche, R. Bianchi, A. Sanchez, T. Sevilla, J. M. Ketelslegers, A. Domzal-Stryga, M. Pandolfo, M. O. Josse, K. W. Neff, I. Blanco, G. W. Bruyn, O. W. Witte, J. L. Thibault, G. Andersen, J. Pariset, A. Marcone, R. J. M. Lane, A. Hofman, M. Verin, T. Matilla, P. Bedoucha, J. Roche, M. Lai, M. Collard, A. Ugarte, F. Gallecho, D. Silbersweig, C. Kennard, J. P. Azulay, T. W. Ho, P. L. I. Dellemijn, R. Girardello, F. Baas, B. Voss, F. Rozenberg, E. M. Brocker, V. Stanev, A. A. J. Soeterboek, A. Marra, A. Rey, E. Ertem, M. Sawradewicz-Rybak, J. De Keyser, P. Cavallari, F. Proust, Y. Chevalier, H. C. Hansen, D. Leys, C. A. Davie, K. Hoang-Xuan, C. Bairati, H. van Crevel, Thomas T. Warner, B. Bompais, A. Dobbeleir, T Campbell, C. Macko, C. J. M. Klijn, M. Dussallant, T. P. Berlit, W. Rozenbaum, M. J. van den Bent, W. A. Rocca, M. Muller, H. Hundemer, U. Zifko, M. Campera, F. Drislane, D. Ranoux, T. M. Kloss, Anil Kumar, I. Ruolt, C. Bargnani, B. Marescau, N. A. Losseff, S. Notermans, B. Kint, E. T. Burke, C. Aykut, J. Matias Guiu, P. Maquet, T. Drogendijk, M. Leone, K. von Ammon, M. Pepeliarska, C. Prados, L. DiGiamberardino, T. Logtenberg, G. Lenoir, I. Castaldo, Damhaut, M. Radionova, G. Sirabian, R. Navon, Giovanni Antonini, K. Al Moutaery, E. Chamas, R. Schönhuber, M. Giannini, B. Debilly, I. Labatut, H. Henon, J. A. Egido, M. Baudrimont, J. N. Lorenzo, J. E. C. Bromberg, R. Antonacci, J. J. Vilchez, T. Moulin, B. Rautenstrauss, Giovanni Meola, J. Noth, S Mammi, P. Laforet, F. Lopez, C. Gehring, S. Bort, G. Rancurel, D. Decamps, S. Kostadinova, Y. Shapira, B. Neundoerfer, D. Chavrot, M. Solimena, J. P. Salier, W. Deberdt, R. Hoff-Jörgensen, A. Messina, S. Meairs, G. Rosoklija, E. Nelis, I. Bertran, C. Ertekin, J. Lohmeyer, Mitermayer Galvao dos Reis, L. Calo, E. Maccagnano, A. P. Hays, J. Verlooy, M. G. Forno, T. Blanco, L. Bail, Gabriella Silvestri, J. Montero, F. Bertrand, R. T. Ghnassia, C. Besses, T. Sereghy, F. Shalit, G. Bogliun, S. Braghi, St. Baykouchev, C. Franke, A. Lasa, L. C. Archard, J. Kriebel, S. Shaunak, M. Nocito, Alexander Tsiskaridze, E. Manfredini, T. Seigal, David G. Gadian, M. Barlas, J. D. Degos, C. Seeber, J. Caemert, J. L. Mas, R. B. Pepinsky, M. G. D'Angelo, N. Baumann, S. Yorifuji, H. P. Endtz, M. A. Cassatella, R. A. C. Hughes, V. Golzi, A. Bittencourt, A. Ferreira, M. Sanson, C. Alper, M. Vermeulen, M. A. A. van Walderveen, E. Alexiou, C. H. Lucas, M. Fiorelli, Y. N. Debbink, R. Gil, S. Congia, T. Banerjee, J. M. Bouchard, A. N. Pinto, A. Ceballos-Baumann, G. Grollier, P. I. M. Schmitz, M. D. Catata, N. Lahat, N. S. Rao, P. Papathanasopoulos, J. Valls-Solé, D. Claus, G. Schroter, A. Castro, C. Videbaek, R. Martinez Dreke, A. D. Platts, M. Hermesl, A. C. PeÇanha-Martins, M. Cardoso Silva, P. Masnou, M. J. A. Tanner, Ch. Confavreux, B. Mishu, H. Rasmussen, L. Valenciano, Carlo Pozzilli, S. W. Li, V. Salzman, Y. Vashtang, Massimo Franceschi, M. Severo, G. Deuschl, S. Setien, G. Mariani, A. Protti, J. Castillo, M. J. B. Taphoorn, M. Frontali, I. Milonas, D. Decoq, J. A. Navarro, S. Castellvi-Pel, C. Ertikin, M. Urtasun, Y. Lajat, B. E. Kendall, E. Verdu, B. Gueguen, E. Boisen, R. Couderc, A Danek, JM Stevens, F. Nicoli, L. Feltri, M. L. Vazquez-Andre, J. A. Morgan-Hughes, L. D'Angelo, F. Y. Liew, L. F. Pascual, J. Patrignani Ochoa, Vittorio Martinelli, J. Cophignon, L. Zhang, S. Martin, J. F. Meder, H. C. Buschmann, L. Bertin, J. van Gijn, A. Barreiro, A. Cools, C. Leon, A. Berod, E. A. Anllo, E. Zanette, L. Petrov, R. Barona, B. Gallicchio, P. J. Cozzone, N. Diederich, G. Cancel, L. Schelosky, P. Orizaola, K. Yulug, S. Ozer, Valeria A. Sansone, B. Guiraud-Chaumeil, K. Voigt, P. Labauge, M. Eoli, J. Zhu, J. Aguirre, M. Ferrarini, B. Zyluk, E. Planas, A. Cadilha, C. Tortorella, H. Bismuth, C. E. Counsell, A. Laun, A. Ferlini, Rio J. Montalban, N. Biary, L. Becker, M. Fardeau, M. Poloni, V. M. S. de Bruin, C. Fornada, J. Barros, E. Ganzmann, E. Touze, D. Wallach, J. Peila, H. Fujimura, M. T. Iba-Zizen, G. Macchi, C. Villoslada, R. Gouider, Ph. Rondepierre, P. Grummich, P. Chiodi, C. Conte, M. Michels, P. Annunziata, G. Semana, C. Sommer, J. Vajsar, D. Zekin, J. Kulisevsky, David G. Munoz, B. Jacotot, M. Magoni, A. Luxen, T. Garcia-Silva, S. Di Cesare, Christophe Tzourio, M. Gomori, I. Picomell, L. Santoro, F. Villa, Giovanni Pennisi, T. Ribalta, J. M. Molto, L. Marzorati, P. Loiseau, F. Gemignani, A. Gironell, J. Wissel, A. Prusinski, F. Cailloux, P. Villanueva-Hemandez, P. Cozzone, T. Del Ser, J. Sans-Sabrafen, M. Zappia, P. W. A. Willems, G. Tchernia, D. Gardeur, R. Bauer, F. Palomo, H. Metz, S. Lamoureux, C. Chastang, I. Reinhard, A. Goldfarb, S. Harder, Jordi Río, C. Ozkara, E. Tekinsoy, P. Vontobell, J. De Recondo, M. Rabasa, L. Lacomblez, F. Boon, Dgt Thomas, V. Palma, Renato Mantegazza, A. Dervis, M. Nueckel, B. YalÇinerner, I. Duran, G. Dalla Volta, A. Zubimendi, J. Pinheiro, A. Marbini, Xavier Montalban, H. Wekerle, X. Pereira Monteino, F. Crespo, F. Koskas, N. Battistini, C. Ruiz, H. Offner, J. de Pommery, P. Kanovsky, J. Y. Barnett, J. Pardo, G. Tomei, R. Rene, H. M. Lokhorst, P. Thajeb, H. Bilgin, D. McGehee, R. Fahsold, L. Morgante, Katie Sidle, C. Delwaide, M. N. Diaye, P. H. Rice, A. Creange, C. Sabev, K. Stephan, K. WeilBenborn, G. Magnani, L. Grymonprez, F. Cardellach, M. Kaps, N. G. Meco, F. Vega, V. Bonifati, A. Desomer, M. Baldy-Moulinier, G. Kvale, F. J. Authier, B. Yegen, T. Ho, J. M. Rozet, E. A. Cabanis, L. Bruce, L. Ambrosoli, M. A. Petrella, M. Hernandez, P. Timmings, H. B. van der Worp, F. Mahieux, A. Urbano-Marquez, D. A. Krendel, A. A. Garcia, R. Divari, R. Michalowicz, M. R. Piedmonte, M. Bondavalli, M. Zanca, P. F. Ippel, Onofre Combarros, B. Tavitian, E. Hirsch, I. Anastasopoulos, A. Roses, A. Köhler, P. Vienna, V. Timmerman, P. Sergi, F. Cornelio, A. Di Pasquale, R. Verleger, S. Castellvirel, J. Proano, B. van Moll, F. Rubio, W. Hacke, I. Lavenu, L. Zetta, M. W. Tas, N. Bittmann, M. Bonamini, O. R. Hommes, V. Dousset, N. Afsar, S. Belal, R. R. Myers, J. Goes, Giuseppe Vita, E. Clementi, V. G. Karepov, M. Jueptner, A Vincent, P. Emmrich, Th. Heb, A. Caballo, J. Gallego, T. Mokrusch, C. Perla, L. Gebuhrer, O. Titlbach, Alessandro Prelle, A. Czlonkowska, M. Russo, D. Hadjiev, T. S. Chkhikvishvili, M. Oehlschlager, G. Becker, I. Günther, E. N. Stenager, J. Garcia Agundez, J. Casademont, J. Batlle, S. Podobnik-Sarkanji, C. Alonso-Villaverde, B. Delaguillaume, B. Genc, B. Mazoyer, A. Rodriguez-Al-barino, Ch. Hilger, B. Ferrero, R. Price, W. Grisold, L. Fuhry, D. Oulbani, D. Ewing, A. Petkov, W. Walther, A. Gokyigit, John Newsom-Davis, J. Tayot, D. Seliak, G. Pelliccioni, D. Campagne, K. Kessler, F. Boureau, D. Perani, J. P. N'Guyen, N. Tchalucova, B. A. Antin-Ozerkis, C. Lacroix, B. D. Aronovich, I. H. Jenkins, E. A. dos Reis, M. Hortells, H. M. Meinck, H. Ch. Buschmann, S. C. J. M. Jacobs, T. Wetter, P. Creissard, N. Martinez, J. Weidenfeldl, H. J. Sturenburg, G. Damlacik, V. Gracia, J. C. Turpin, A. Pou-Serradell, J. P. Vincent, T. Gagoshidze, U. Ozkutlu, M. McLeod, K. Siegfried, I. Tchaoussoglou, J. Hildebrand, S. Kowalska, M. C. Picot, G. Galardin, L. Crevits, F. Andreetta, S. Larumbe-Lobalde, G. de la Sierra, J. C. Alvarez-Cermeno, R. J. Seitz, P. L. Oey, L. Ptacek, A. M. J. Paans, A. Wirrwar, A. Schmied, J. Uilchez, H. Tounsi, D. Hipola, V. Avoledo, Y. Hirata, P. Vermersch, T. M. Aisonobe, J. Valls-SoIè, H. Staunton, J. Dichgans, R. Karabudak, I. Dones, G. Porta, E. Janssens, Maria Martinez, J. M. Fernandez-Real, R. Villagra, Y. Yoshino, C. Kabus, K. Schimrigk, I. Girard-Buttaz, F. Piccoli, F. Aichner, P. Zuchegna, S. M. Al Deeb, F. Bono, N. Busquets, A. Jobert, Patrizia Ciscato, M. Martin, L. Polman, S. Darbra, V. Le Cam-Duchez, F. Baldissera, B. Baykan-Kurt, D. Guez, M. Bratoeva, H. Matsui, M. Mila, H. Perron, L. Bjorge, G. Husby, Steven T. DeKosky, D. R. Cornblath, J. M. Gabriel, J. J. Poza, Y. Wu, A. Toscano, R. P. Kleyweg, J. Kuhnen, S. O. Confort-Gouny, A. Barcelo, A. M. Conti, C. Fiol, C. Steichen-Wiehn, J. Rodes, M. Cavenaile, C. Vedeler, M. Drlicek, C. Argentino, M. L. Peris, A. Cervello, A. Z. GinaÏ, S. Yancheva, D. Passingham, S. Aoba, D. L. Lopez, T. Rechlin, K. Sonka, L. Grazzi, V. Folnegovic-Smalc, Maurizio Moggio, S. Rivaud, F. G. I. Jennekens, C. H. Hartard, H. Meierkord, G. Stocklin, M. D. Catala, W. C. McKay, E. Salmon, C. Navarro, I. Pastor, L. Canafoglia, M. De Braekeleer, P. K. Thomas, C. Mocellini, C. Pierre-Jerome, M. C. Dalakas, P. Pollak, M. Levivier, Niall Quinn, G. E. Rivolta, Z. Tunca, H. Zeumer, J. Garcia Tena, St. Guily, P. Gaudray, Johannes Kornhuber, V. Petrunjashev, R. Montesanti, R. J. Abbott, H. Petit, G. Kiteva-Trencevska, F. Carletto, C. Ramo, I. M. Pino, P. Beau, G. F. Mennuni, F. Moschian, F. Meneghini, B. Zdziarska, B. Fontaine, C. Stephens, G. Meco, K. Reiners, G. Badlan, M. Sessa, I. Degaey, S. M. Hassan, C. Albani, F. Caroeller, M. Schroeder, G. Savettieri, A. Novelletto, R. Kurita, P. Oschmann, I. Plaza, M. Oliveres, Simone Spuler, A. Molins, M. Schwab, J. R. Kalden, C. P. Gennaula, Y. Baklan, O. Picard, J. M. Léger, B. Mokri, E. Ghidoni, M. Jacob, D. Deplanque, W. JÄnisch, C. De Andres, P. De Deyn, G. Guomundsson, B. Herron, J. Barado, J. L. Gastaut, Guglielmo Scarlato, F. Poron, Nicola Jones, H. Teisserenc, C. P. Hawkins, A. J. Steck, H. C. Chandler, S. Blanc, J. H. Faiss, Jm. Soler Insa, I. Sarova-Ponchas, M. Malberin, A. Sackmann, G. De Vuono, K. Kaiser-Rub, K. Badhia, E. Szwabowska-Orzeszko, S. Ramm, C. Jodice, G. Franck, J. Marta-Moreno, R. Sciolla, C. Fritz, A. Attaccalite, F. Weber, E. Neuman, M. Cannata, A. Rodriguez, I. Nachainkin, R. Raffaele, T. S. Yu, N. Losseff, E. Fabrizio, C. Khati, M. Keipes, M. P. Ortega, M. Ramos-Alvarez, E. Brambilla, A. Tarasov, K. H. Wollinsky, O. B. Paulson, F. Boller, G. Bozzato, H. Wagnur, R. Canton, D. Testa, E. Kutluaye, M. Calopa, D. Smadja, G. Malatesta, F. Baggi, A. Stracciari, G. Daral, G. Avanzini, J. Perret, J. Arenas, P. Boon, I. Gomes, A. Vortmeyer, P. Cesaro, S. Venz, E. Bernd Ringelstein, N. Milani, D. Laplane, P. Seibel, E. Tournier-Lasserve, Alexis Brice, L. Motti, E. Wascher, R. J. Abbot, F. 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Henderson, R. Massa, A. Cruz Martinez, U. Liska, F. Hecht, Ernst Holler, V. S. de Bruin, B. B. Sheitman, S. M. Bentzen, C. Bayindir, F. Pallesta, P. E. Roland, J. Parrilla, P. Zunker, L. F. Burchinskaya, G. Mellino, S. Ben Ayed, D. Bonneau, P. Nowacki, M. Goncalves, P. Riederer, N. Mavroudakis, J. Togores, L. Rozewicz, S. Robeck, Y. Perez Gilabert, L. Rampello, A. Rogopoulos, S. Martinez, F. Schildermans, C. Radder, P. B. Hedlund, J. Cambier, M. Aabed, G. D. Jackson, P. Gasparini, P. Santacruz, J. Vandevivere, H. Dural, A. Mantel, W. Dorndorf, N. Ediboglu, A. Lofgren, J. Bogousslavsky, P. Thierauf, L. Goullard, R. Maserati, B. Moering, M. Ryba, J. Serra, G. G. Govan, A. Pascual-Leone, S. Schaeffer, M. R. Rosenfeld, A. P. Correia, K. Ray Chaudhuri, L. Campbell, R. Spreafico, B. Genetet, A. M. Tantot, R. A. G. Hughes, J. A. Vidal, G. Erkol, J. Y. Delattre, B. Yaqub, B. K. Hecht, E. Mayayo, Ph. Scheltens, J. Corral, M. Calaf, L. Henderson, C. Y. Li, U. Bogdahn, R. Sanchez-Roy, M. Navasa, J. Ballabriga, G. Broggi, T. Gudeva, C. Rose, J. Vion-Dury, J. A. Gastaut, J. Pniewski, Nicola J. Robertson, G. Kohncke, M. Billot, S. Gok, E. Castellli, F. Denktas, P. Bazzi, F. Spinelli, I. F. Moseley, C. D. Mardsen, B. Barbiroli, O. M. Koriech, A. Miller, Hiroaki Yoshikawa, F. X. Borruat, J. Zielasek, P. Le Coz, J. Pascual, A. Drouet, L. T. Giron, F. Schondube, R. Midgard, M. Alizadeh, M. Liguori, Lionel Ginsberg, L. Harms, C. Tilgner, G. Tognoni, F. Molteni, Mar Tintoré, M. Psylla, C. Goulon-Goeau, M. V. Aguilar, Massimo Filippi, K. H. Mauritz, Thomas V. Fernandez, C. Basset, S. Rossi, P. Meneses, B. Jandolo, T. Locatelli, D. Shechtcr, C. Magnani, R. Ferri, Bruno Dubois, J. M. Warier, S. Berges, F. Idiman, M. Schabet, R. R. Diehl, P. D'aurelio, M. Musior, Reinhard Hohlfeld, P. Smeyers, M. Olivé, A. Riva, C. A. Broere, N. Egund, S. Franceschetti, V. Bonavita, Nicola Canal, E. Timmermans, M. Ruiz, S. Barrandon, G. Vasilaski, B. Deweer, L. Galiano, S. F. T. M. de Bruijn, L. Masana, A. Goossens, B. Heye, K. Lauer, Heinz Gregor Wieser, Stephen R. Williams, B. Garavaglia, A. P. Sempere, F. Grigoletto, P. Poindron, R. Lopez-Pajares, I. Leite, T. A. McNell, C. Caucheteur, J. M. Giron, A. D. Collins, P. Freger, J. Sanhez Del Rio, D. A. Harn, K. Lindner, S. S. Scherer, G. Serve, M. Juncadella, X. Estivill, R. Binkhorst, M. Anderson, B. Tekinsoy, C. Sagan, T. Anastopoulos, G. Japaridze, S. Guillou, F. Erminio, Jon Sussman, P. G. Oomes, D. S. Rust, S. Mascheroni, O. Berger, M. Peresson, K. V. Toyka, T. W. Polder, M. Huberman, B. Arpaci, H. Ramtami, I. Martinez, Ph. Violon, P. P. Gazzaniga Pozzill, R. Ruda, P. Auzou, J. Parker, S. P. Morrissey, Jiahong Zhu, F. Rotondi, P. Baron, W. Schmid, P. Doneda, M. Spadaro, M. C. Nargeot, I. Banchs, J.S.P. van den Berg, R. Ferrai, M. Robotti, M. Fredj, Pedro M. Rodríguez Cruz, B. Erne, D. G. Piepgras, M. C. Arne-Bes, J. Escudero, C. Goetz, A. R. Naylor, M. Hallett, O. Abramsky, E. Bonifacio, L. E. Larsson, R. Pellikka, P. Valalentino, D. Guidetti, B. Buchwald, C. H. Lücking, D. Gauvreau, F. Pfaff, A. Ben Younes-Chennoufi, R. Kiefer, R. Massot, K. A. Hossmann, L. Werdelin, P. J. Baxter, U. Ziflo, S. Allaria, C. D. Marsden, M. Cabaret, S. P. Mueller, E. Calabrese, R. Colao, S. I. Bekkelund, M. Yilmaz, O. Oktem-Tanor, R. Gine, M. E. Scheulen, J. Beuuer, A. Melo, Z. Gulay, M. D. Have, C. Frith, D. Liberati, J. Gozlan, P. Rondot, Ch. Brunholzl, M. Pocchiari, J. Pena, L. Moiola, C. Salvadori, A. Cabello, T. Catarci, S. Webb, C. Dettmers, N. A. Gregson, Alexandra Durr, F. Iglesias, U. Knorr, L. Ferrini-Strambi, F. Kruggel, P. Allard, A. Coquerel, P. Genet, F. Vinuels, C. Oberwittler, A. Torbicki, P. Leffers, B. Renault, B. Fauser, C. Ciano, G. Uziel, J. M. Gibson, F. Anaya, C. Derouesné, C. N. Anagnostou, M. Kaido, W. Eickhoff, G. Talerico, M. L. Berthier, A. Capdevila, M. Alons, D. Rezek, E. Wondrusch, U. Kauerz, D. Mateo, M. A. Chornet, Holon, N. Pinsard, I. Doganer, E. Paoino, H. Strenge, C. Diaz, J. R. Brasic, W. Heide, I. Santilli, W. M. Korn, D. Selcuki, M. J. Barrett, D. Krieger, T. Leon, T. Houallah, M. Tournilhac, C. Nos, D. Chavot, F. Barbieri, F. J. Jimenez-Jimenez, J. Muruzabal, K. Poeck, A. Sennlaub, L. M. Iriarte, L. G. Lazzarino, C. Sanz, P. A. Fischer, S. D. Shorvon, R. Hoermann, F. Delecluse, M. Krams, O. Corabianu, F. H. Hochberg, Christopher J. Mathias, B. Debachy, C. M. Poser, L. Delodovici, A. Jimenez-Escrig, F. Baruzzi, F. Godenberg, D. Cucinotta, P. J. Garcia Ruiz, K. Maier-Hauff, P. R. Bar, R. Mezt, R. Jochens, S. Karakaneva, C. Roberti, E. Caballero, Joseph E. Parisi, M. Zamboni, T. Lacasa, B. Baklan, J. C. Gautier, J. A. Martinez-Matos, W. Pollmann, G. Thomas, L. Verze, E. Chleide, R. Alvarez Sala, I. Noel, E. Albuisson, O. Kastrup, S. I. Rapoport, H. J. Braune, H. Lörler, M. Le Merrer, A. Biraben, S. Soler, S. J. Taagholt, U. Meyding-Lamadé, K. Bleasdale-Barr, Isabella Moroni, Y. Campos, J. Matias-Guiu, G. Edan, M. G. Bousser, John B. Clark, J. Garcia de Yebenes, N. K. Olsen, P. Hitzenberger, S. Einius, Aj Thompson, Ch. J. Vecht, T. Crepin-Leblond, Klaus L. Leenders, A. Di Muzio, L. Georgieva, René Spiegel, K. Sabey, D. Ménégalli, J. Meulstee, U. Liszka, P. Giral, C. Sunol, J. M. Espadaler, A. D. Crockar, K. Varli, G. Giraud, P. J. Hülser, A. Benazzouz, A. Reggio, M. Salvatore, K. Genc, M. Kushnir, S. Barbieri, J. Ph. Azulay, M. Gianelli, N. Bathien, A. AlMemar, F. Hentati, I. Ragueneau, F. Chiarotti, R. C. F. Smits, A. K. Asbury, F. Lacruz, B. Muller, Alan J. Thompson, Gordon Smith, K. Schmidt, C. Daems Monpeun, Juergen Weber, A. Arboix, G. R. Fink, A. M. Cobo, M. Ait Kaci Ahmed, E. Gencheva, Israel-Biet, G. Schlaug, P. De Jonghe, Philip Scheltens, K. Toyka, P. Gonzalez-Porque, A. Cila, J. M. Fernandez, P. Augustin, J. Siclia, S. Medaglini, D. E. Ziogas, A. Feve, L. Kater, G. J. E. Rinkel, D. Leppert, Rüdiger J. Seitz, S. Ried, C. Turc-Carel, G. Smeyers, F. Godinho, M. Czygan, M. Rijntjes, E. Aversa, M. Frigo, Leif Østergaard, J. L. Munoz Blanco, A. Cruz-Matinez, J. De Reuck, C. Theillet, T. Barroso, V. Oikonen, Florence Lebert, M. Kilinc, C. Cordon-Cardon, G. Stoll, E. Thiery, F. Pulcinelli, J. Solski, M. Schmiegelow, L. J. Polman, P. Fernandez-Calle, C. Wikkelso, M. Ben Hamida, M. Laska, E. Kott, W. Sulkowski, C. Lucas, N. M. Bornstein, D. Schmitz, M. W. Lammers, A. de Louw, R. J. S. Wise, P. A. van Darn, C. Antozzi, P. Villanueva, P. H. E. Hilkens, C. Constantin, W. Ricart, A. Wolf, M. Gamba, P. Maguire, Alessandro Padovani, B. M. Patten, Marie Sarazin, H. Ackermann, L. Durelli, S. Timsit, Sebastian Jander, B. W. Scheithauer, G. Demir, J. P. Neau, P. Barbanti, A. Brand, N. AraÇ, V. Fischer-Gagnepain, R. Marchioli, G. Serratrice, C. Maugard-Louboutin, G. T. Spencer, D. Lücke, G. Mainardi, K. Harmant Van Rijckevorsel, G. B. Creel, R. Manzanares, Francesco Fortunato, A. May, J. Workman, K. Johkura, E. Fernandez, Carlo Colosimo, L. Calliauw, L. Bet, Félix F. Cruz-Sánchez, M. Dhib, H. Meinardi, F. Carrara, J. Kuehnen, C. Peiro, H. Lassmann, K. Skovgaard Olsen, A. McDonald, L. Sciulli, A. Cobo, A. Monticelli, B. Conrad, J. Bagunya, J. Benitez, V. Desnizza, B. Dupont, O. Delrieu, D. Moraes, J. J. Heimans, F. Garcia Rio, M. Matsumto, A. Fernandez, R. Nermni, R. Chalmers, M. J. Marchau, F. Aguado, P. Velupillai, P. J. Martin, P. Tassan, V. Demarin, A. Engelien, T. Gerriets, Comar, J. L. Carrasco, J. P. Pruvo, A. Lopez de Munain, D. Pavitt, J. Alarcon, Chris H. Polman, B. Guldin, N. Yeni, Hartmut Brückmann, N. Wilczak, H. Szwed, R. Causaran, G. Kyriazis, M. E. Westarp, M. Gasparini, N. Pecora, J. M. Roda, E. Lang, V. Scaioli, David R. Fish, D. Caputo, O. Gratzl, R. Mercelis, A. Perretti, G. Steimetz, I. Link, C. Rigoletto, A. Catafau, G. Lucotte, M. Buti, G. Fagiolari, A. Piqueras, C. Godinot, J. C. Meurice, Erodriguez J. Dominigo, F. Lionnet, H. Grzelec, David J. Brooks, P. M. G. Munro, F. X. Weilbach, M. Maiwald, W. Split, B. Widjaja-Cramer, V. Ozturk, J. Colas, E. Brizioli, J. Calleja, L. Publio, M. Desi, R. Soffietti, P. Cortinovis-Tourniaire, E. F. Gonano, G. Cavaletti, S. Uselli, K. Westerlind, H. Betuel, C. O. Dhiver, H. Guggenheim, M. Hamon, R. Fazio, P. Lehikoinen, A. Esser, B. Sadzot, G. Fink, Angelo Antonini, D. Bendahan, V. Di Carlo, G. Galardi, A. F. Boller, M. Aksenova, Del Fiore, V. de la Sayette, H. Chabriat, A. Nicoletti, A. Dilouya, M. L. Harpin, E. Rouillet, J. Stam, A. Wolters, M. R. Delgado, Eduardo Tolosa, G. Said, A. J. Lees, L. Rinaldi, A. Schulze-Bonhage, MA Ron, C. Lefebvre, E. W. Radü, R. Alvarez, M. L. Bots, P. Reganati, S. Palazzi, A. Poggi, N. J. Scolding, V. Sazdovitch, T. Moreau, E. Maes, M. A. Estelies, P. Petkova, Jose-Felix Marti-Masso, G De La Meilleure, N. Mullatti, M. Rodegher, N. C. Notermans, T. A. T. Warner, S. Aktan, J. P. Louboutin, L. Volpe, C. Scheidt, W. Aust, C. M. Wiles, U. Schneider, S. K. Braekken, W. R. Willems, K. Usuku, Peter M. Rothwell, C. Talamon, M. L. Sacchetti, A. Codina, M. H. Marion, A. Santoro, J. Roda, A. Bordoni, D. J. Taylor, S. Ertas, H. H. Emmen, J. Vichez, V. BesanÇon, R. E. Passingham, M. L. Malosio, A. Vérier, M. Bamberg, A. W. Hansen, E. Mostacero, G. Gaudriault, Marie Vidailhet, B. Birebent, K. Strijckmans, F. Giannini, T. Kammer, I. Araujo, J. Nowicki, E. Nikolov, A. Hutzelmann, R. Gherardi, J. Verroust, L. Austoni, A. Scheller, A. Vazquez, S. Matheron, H. Holthausen, J. M. Gerard, M. Bataillard, S. Dethy, V. H. Patterson, V. Ivanez, N. P. Hirsch, F. Ozer, M. Sutter, C. Jacomet, M. Mora, Bruno Colombo, A. Sarropoulos, T. H. Papapetropoulos, M. Schwarz, D. S. Dinner, N. Acarin, B. Iandolo, J. O. Riis, P. R. J. Barnes, F. Taroni, J. Kazenwadel, L. Torre, A. Lugaresi, I. L. Henriques, S. Pauli, S. Alfonso, Pedro Quesada, A. S. T. Planting, J. M. Castilla, Thomas Gasser, M. Van der Linden, A. Alfaro, E. Nobile-Orazio, G. Popova, W. Vaalburg, F. G. A. van der Mech, L. Williams, F. Medina, J. P. Vernant, J. Yaouanq, B. Storch-Hagenlocher, A. Potemkowski, R. Riva, M. H. Mahagne, M. Ozturk, Ve. Drory, N. Konic, C. Jungreis, A. Pou Serradell, J. L. Gauvrit, G. J. Chelune, S. Hermandez, T. Dingus, L. Hewer, Ch. Koch, M. N. Metz-Lutz, G. Parlato, M. Sinaki, Charles Pierrot-Deseilligny, H. C. Diener, J. Broeckx, J. Weill-Fulazza, M. L. Villar, M. Rizzo, O. Ganslandt, C. Duran, N. A. Fletcher, G. Di Giovacchino, Susan T. Iannaccone, C. Kolig, N. Fabre, H. A. Crockard, Rita Bella, M. Tazir, E. Papagiannuli, K. Overgaard, Emma Ciafaloni, I. Lorenzetti, F. Viader, P. A. H. Millac, I. Montiel, L. H. Visser, M. Palomar, P. L. Murgia, H. Pedersen, Rafael Blesa, S. Seddigh, W. O. Renier, I. Lemahieu, H. M. L. Jansen, L. Rosin, J. Galofre, K. Mattos, M. Pondal, G. M. Hadjigeorgiou, D. Francis, L. Cantin, D. Stegeman, M. Rango, A. B. M. F. Karim, S. Schraff, B. Castellotti, I. Iriarte, E. Laborde, T. J. Tjan, R. Mutani, D. Toni, B. Bergaasco, J. G. Young, C. Klotzsch, A. Zincone, X. Ducrocq, M. Uchuya, O. J. Kolar, A. Quattrone, T. Bauermann, Nereo Bresolin, J. Vallée, B. C. Jacobs, A. Campos, Werner Poewe, J. A. Villanueva, A. W. Kornhuber, A. Malafosse, E. Diez-Tejedor, G. Jungreia, M. J. A. Puchner, A. Komiyama, O. Saribas, V. Volpini, L. Geremia, S. Bressi, A. Nibbio, Timothy E. Bates, T. z. Tzonev, E. Ideman, G. A. Damlacik, G. Martino, G. Crepaldi, T. Martino, Kjell Någren, E. Idiman, D. Samuel, J. M. Perez Trullen, Y. van der Graaf, J. O. Thorell, M. J. M. Dupuis, E. Sieber, R. D'Alessandro, C. Cazzaniga, J. Faiss, A. Tanguy, A. Schick, I. Hoksergen, A. Cardozo, R. Shakarishvili, G. K. Wennlng, J. L. Marti-Vilalta, J. Weissenbach, I. L. Simone, Amalia C. Bruni, Darius J. Adams, C. Weiller, A. Pietrangeli, F. Croria, C. Vigo-Pelfrey, Patricia Limousin, A. Ducros, G. Conti, O. Lindvall, E. Richter, M. Zuffi, A. Nappo, T. Riise, J. Wijdenes, M. J. Fernandez, J. Rosell, P. Vermersh, S. Servidei, M. S. C. Verdugo, F. Gouttiere, W. Solbach, M. Malbezin, I. S. Watanabe, A. Tumac, W. I. McDonald, D. A. Butterfield, P. P. Costa, F. deRino, F. Bamonti, J. M. Cesar, C. H. Lahoz, I. Mosely, M. Starck, M. H. Lemaitre, K. M. Stephan, S. Tex, R. Bokonjic, I. Mollee, L. Pastena, M. Gutierrez, F. Boiler, M. C. Martinez-Para, M. Velicogna, O. Obuz, A. Grinspan, M. Guarino, L. M. Cartier, E. Ruiz, D. Gambi, S. Messina, M. Villa, Michael G. Hanna, J. Valk, Leone Pascual, M. Clanet, Z. Argov, B. Ryniewicz, E. Magni, B. Berlanga, K. S. Wong, C. Gellera, C. Prevost, F. Gonzalez-Huix, R. Petraroli, J. E. G. Benedikz, I. Kojder, C. Bommelaer, L. Perusse, M. R. Bangioanni, Guy M. McKhann, A. Molina, C. Fresquet, E. Sindern, Florence Pasquier, M. J. Rosas, M. Altieri, O. Simoncini, M. Koutroumanidis, C. A. F. Tulleken, M. Dary-Auriol, S. Oueslati, H. Kruyer, I. Nishisho, C. R. Horning, A. Vital, G. V. Czettritz, J. Ph. Neau, B. Mihout, A. Ameri, M. Francis, S. Quasthoff, D. Taussig, S. Blunt, P. Valentin, C. Y. Gao, O. Heinzlef, H. d'Allens, C. Coudero, M. Erfas, G. Borghero, P. J. Modrego Pardo, M. C. Patrosso, N. L. Gershfeld, P. A. J. M. Boon, O. Sabouraud, M. Lara, J. Svennevig, G. L. Lenzi, A. Barrio, H. Villaroya, JosÇ M. Manubens, O. Boespflug-Tanguy, M. Carreras, D. A. Costiga, J. P. Breux, S. Lynn, C. Oliveras Ley, A. G. Herbaut, J. Nos, C. Tornali, Y. A. Hekster, J. L. Chopard, J. M. Manubens, P. Chemouilli, A. Jovicic, F. Dworzak, S. Smirne, S. E. Soudain, B. Gallano, D. Lubach, G. Masullo, G. Izquierdo, A. Pascual Leone Pascual, A. Sessa, V. Freitas, O. Crambes, L. Ouss, G. W. Van Dijk, P. Marchettini, P. Confalonieri, M. Donaghy, A. Munnich, M. Corbo, and M. E. L. van der Burg

Subjects
Neurology, business.industry, Media studies, Library science, Medicine, Neurology (clinical), business
Published
1994

33. Annual Meeting of the World Federation of Neurology Research Group on Neuroepidemiology. pp 121–127

Author

Robin S. Roberts, L. Masini, Pesus Chou, Carlo Salvarani, R. Sabadini, M. Prencipe, F. Solimé, M. Baratti, Rong Chi Chen, Domenico Inzitari, Trond Riise, M. Luisa Monticelli, Grethe Albrektsen, Harald Nyland, Craig A. Molgaard, S. Terenziani, M. Bondavalli, Jackson C.T. Lin, John N. Danesh, Cesare Fieschi, Ettore Beghi, Marit Grønning, R. Zucco, Chen-Hsin Chen, G. Greco, Luciano De Zanche, Julia T. Tsuei, Graeme S. Dixon, Richard A. Smith, Tudor H. Caradoc-Davies, Carlo Gandolfo, Han-Hwa Hu, Chieh Chung, D. Guidetti, Gunnar Kvåle, Tcho Jen Liu, Rune Midgard, Carmine Marini, E. Vescovini, Wei-San Huang, Ugo Scoditti, Gianluca Landi, Louise S. Gresham, and Antonio Carolei

Subjects
medicine.medical_specialty, Neurology, Epidemiology, business.industry, Group (periodic table), Family medicine, medicine, Neuroepidemiology, Neurology (clinical), business
Published
1993

34. Title Page / Abstracts / Session I / Poster Session / Session II

Author

Gianluca Landi, Grethe Albrektsen, Harald Nyland, D. Guidetti, Gunnar Kvåle, Luciano De Zanche, Robin S. Roberts, Louise S. Gresham, Ettore Beghi, R. Sabadini, Jackson C.T. Lin, John N. Danesh, M. Baratti, Marit Grønning, Trond Riise, F. Solimé, Chen-Hsin Chen, M. Prencipe, Rong Chi Chen, Wei-San Huang, G. Greco, Antonio Carolei, Carlo Salvarani, Julia T. Tsuei, Graeme S. Dixon, Domenico Inzitari, M. Luisa Monticelli, Ugo Scoditti, Chieh Chung, Han-Hwa Hu, R. Zucco, Tcho Jen Liu, Pesus Chou, Cesare Fieschi, Richard A. Smith, Tudor H. Caradoc-Davies, E. Vescovini, Craig A. Molgaard, Carlo Gandolfo, Rune Midgard, Carmine Marini, L. Masini, M. Bondavalli, and S. Terenziani

Subjects
Epidemiology, business.industry, Library science, Medicine, Neurology (clinical), Session (computer science), Title page, business
Published
1993

35. Annual Meeting of the World Federation of Neurology Research Group on Neuroepidemiology. pp 128–138

Author

Tcho Jen Liu, M. Baratti, Trond Riise, Jackson C.T. Lin, F. Solimé, M. Bondavalli, Gunnar Kvåle, L. Masini, Carlo Salvarani, Craig A. Molgaard, Richard A. Smith, Tudor H. Caradoc-Davies, Chen-Hsin Chen, Chieh Chung, Cesare Fieschi, Ettore Beghi, Marit Grønning, Robin S. Roberts, Louise S. Gresham, M. Luisa Monticelli, G. Greco, Julia T. Tsuei, Ugo Scoditti, D. Guidetti, Graeme S. Dixon, Wei-San Huang, R. Sabadini, Harald Nyland, Han-Hwa Hu, John N. Danesh, Antonio Carolei, E. Vescovini, S. Terenziani, Carlo Gandolfo, Rune Midgard, Carmine Marini, Luciano De Zanche, Grethe Albrektsen, Pesus Chou, Rong Chi Chen, M. Prencipe, Domenico Inzitari, R. Zucco, and Gianluca Landi

Subjects
Gerontology, medicine.medical_specialty, Neurology, Epidemiology, Group (periodic table), business.industry, Medicine, Neuroepidemiology, Neurology (clinical), business
Published
1993

37. Peroneal muscular atrophy with hereditary spastic paraparesis (HMSN V) is pathologically heterogeneous

Author

P. Bizzi, Giovanna Cenacchi, D. Guidetti, Adriana Marbini, Franco Gemignani, and P. Preda

Subjects
Adult, Male, Pathology, medicine.medical_specialty, Hereditary spastic paraplegia, Biopsy, Population, Sural nerve, Pathology and Forensic Medicine, Electrocardiography, Cellular and Molecular Neuroscience, Sural Nerve, medicine, Humans, Hereditary Sensory and Autonomic Neuropathies, education, education.field_of_study, Nerve biopsy, medicine.diagnostic_test, Electromyography, business.industry, Muscles, Electroencephalography, Peroneal muscular atrophy, Middle Aged, medicine.disease, Peripheral neuropathy, Female, Neurology (clinical), Hereditary motor and sensory neuropathy, business
Abstract

Peroneal muscular atrophy (PMA) associated with hereditary spastic paraparesis (HSP) is a nosologically ill-defined disease, which has been classified by Dyck as hereditary motor and sensory neuropathy type V (HMSN V). Nerve biopsy has been rarely reported in this condition. We examined sural nerve biopsies in four patients, demonstrating the following: severe myelinated fiber loss especially of large fibers, with moderate (one case) or prominent (one case) onion bulb formation; selective decrease of large fibers with moderate Schwann cell hyperplasia (one case); normal myelinated fiber population with minimal changes (one case). After reviewing previously reported cases we, conclude that in PMA with HSP sural nerve biopsy may show features either of hypertrophic type of PMA, of neuronal type, or of spinal type; thus, it seems inappropriate to allocate PMA with HSP in a unique subtype of HMSN. In addition, HSP may be not associated with peripheral neuropathy, and thus the classification in the HMSN group may be incongruous. A proper classification of PMA with HSP may be in the "complicated" forms of HSP according to Harding [Lancet I: 1151-1155 (1983)]; however, the nosology of this condition needs to be further elucidated, possibly on the basis of the underlying molecular genetic mechanisms of HSP and PMA.

Published
1992

38. [Prevention and therapy of critical ischemia in hemodialyzed patients]

Author

M, Andreoli, G, Galli, A, Arienzo, A, Nora, M, Tedoli, D, Guidetti, R, Pacchioni, G, Ferrari, E, Talassi, A, Serra, and R, Tarchini

Subjects
Aged, 80 and over, Male, Leg, Arterial Occlusive Diseases, Middle Aged, Limb Salvage, Prognosis, Amputation, Surgical, Radiography, Tibial Arteries, Early Diagnosis, Treatment Outcome, Italy, Cardiovascular Diseases, Ischemia, Renal Dialysis, Risk Factors, Humans, Kidney Failure, Chronic, Female, Vascular Surgical Procedures, Vascular Patency, Aged, Follow-Up Studies, Retrospective Studies
Abstract

The cardiovascular disease is largely increased in chronic renal failure and the patients have a 10-20 times higher mortality respect normal population. Besides habitual risk-factors they add the mineral metabolism alterations, iperomocisteine and chronical vessel flogosis. In these patients the vascular disease is often lately diagnosed, but early diagnosis would be extremely important to establish appropriate pharmacologic or surgical treatment (PTA or by pass). The basic diagnostic methods are still digital angiography, angio-NMR or angio-CT. In our experience appears that dialysed patients present high total mortality and re-vascolarization (particularly for peripheral occlusive disease) gives less guarantee of success. During last years endovascular surgery procedures extremely improved short-term prognosis for these patients. When there is no space for the re-vascolarization and the situation is strongly compromised by the presence of extended gangrene or infected lesion, amputation is still indicated and can be considered the only possible solution.

Published
2009

41. Cerebellar Syndrome due to multiple ischemic lesions in hypothyroidism

Author

R. Valcavi, R. Zucco, E. Manicardi, G. Greco, and D. Guidetti

Subjects
Psychiatry and Mental health, medicine.medical_specialty, Pediatrics, Neurology, business.industry, General Neuroscience, Medicine, Neurology (clinical), Dermatology, General Medicine, Neurosurgery, business, Neuroradiology
Published
1990

46. Spontaneous large right-to-left shunt and migraine headache with aura are risk factors for recurrent stroke in patients with a patent foramen ovale

Author

D. Guidetti, Luisa Salomone, Andrea Donti, Fernando M. Picchio, Gualtiero Palareti, Roberto Formigari, and Alessandro Giardini

Subjects
Adult, Male, medicine.medical_specialty, Adolescent, Aura, Right-to-left shunt, Migraine with Aura, Foramen secundum, Thrombophilia, Heart Septal Defects, Atrial, Sex Factors, Recurrence, Risk Factors, medicine.artery, medicine, Humans, Stroke, Aged, Retrospective Studies, business.industry, Middle Aged, medicine.disease, Transcranial Doppler, Surgery, Migraine, Ischemic Attack, Transient, Multivariate Analysis, Patent foramen ovale, Female, Cardiology and Cardiovascular Medicine, business
Abstract

Background We sought to determine whether migraine headache with aura (MHA) and spontaneous large right-to-left (R–L) shunt are risk factors for recurrent cerebral ischemic events in cryptogenic stroke patients with a patent foramen ovale (PFO). Methods 140 patients with a PFO and cryptogenic stroke underwent transcatheter defect closure at our institution at a mean age of 45±13 years. We retrospectively analyzed follow-up data from the first cerebral ischemic event to the time of PFO closure. Before the procedure, all patients underwent transesophageal echocardiography (TEE); Transcranial Doppler scanning (TCD) was additionally performed on the last 59 patients. We analyzed the impact of MHA, thrombophilia, spontaneous large R–L shunt, and atrial septal aneurysm (ASA) on the risk of recurrent cerebral ischemic events. Results 44 patients (31%) had had at least 1 recurrent event during a follow-up of 2.2±2.6 years. Patients with recurrent events were more commonly females ( p =0.0001), had more often an associated thrombophilia ( p =0.0077), and had a higher prevalence of spontaneously large R–L shunt both at TEE and at TCD ( p p =0.0009) and more frequent episodes of MHA ( p =0.0048). Patients with MHA had a higher risk of recurrent events when compared to patients without (odds ratio 3.87, 95% CI 1.75 to 8.50). Thrombophilia ( p =0.001) and spontaneous large R–L shunt ( p =0.02) were independent predictors of recurrent stroke. Conclusions In cryptogenic stroke patients with a PFO, a history of MHA, large spontaneous large R–L shunt, and thrombophilia are all associated with a higher risk of recurrent events.

Published
2006

47. Long-term efficacy of transcatheter patent foramen ovale closure on migraine headache with aura and recurrent stroke

Author

Roberto Formigari, Luisa Salomone, Alessandro Giardini, Andrea Donti, Gualtiero Palareti, Fernando M. Picchio, D. Guidetti, Giardini A, Donti A, Formigari R, Salomone L, Palareti G, Guidetti D, and Picchio FM.

Subjects
Adult, medicine.medical_specialty, Cardiac Catheterization, Time Factors, Aura, Migraine with Aura, Ischemia, Severity of Illness Index, Heart Septal Defects, Atrial, Pfo closure, Recurrent stroke, Risk Factors, medicine, Secondary Prevention, Humans, Radiology, Nuclear Medicine and imaging, Prospective Studies, business.industry, Incidence (epidemiology), Primary care physician, General Medicine, Middle Aged, medicine.disease, Surgery, Stroke, Treatment Outcome, Migraine, Anesthesia, Patent foramen ovale, Cardiology and Cardiovascular Medicine, business, Follow-Up Studies
Abstract

Objectives: To assess the long-term results of transcatheter patent foramen ovale (PFO) closure on migraine headache with aura (MHA) and on the risk of recurrent stroke. Background: Transcatheter PFO closure is associated with an early improvement of MHA, and a reduction or the risk of recurrent cerebral ischemia, but the long-term outcome after the procedure is unknown. Methods: We analyzed follow-up data of 38 consecutive patients who had undergone transcatheter PFO closure at our institution because of cryptogenic stroke and had been followed-up for at least 3 years after the procedure. Mean age at closure was 43 ± 13 years. Thirteen patients (34%) had a diagnosis of MHA made by the primary care physician or the referring neurologist. Migraine disability assessment questionnaire (MIDAS) was used to assess MHA incidence and severity. Results: After a mean follow-up of 4.8 ± 1.4 years, two patients had a recurrent stroke (13 and 15 months after the procedure, respectively). Recurrence rate 5 years after the procedure was 5.3%. After 4.9 ± 1.4 years from the intervention, 12/13 patients (92%, 95% CI 65–99%) had complete resolution in their MHA. Overall, MIDAS score decreased significantly (38.6 ± 26.3 vs. 4.4 ± 5.1, P < 0.0001) after the procedure. One patient did not report any improvement of MHA after transcatheter PFO closure, whereas one patient reported a severe relapse of MHA about 1 year after PFO closure. Freedom from recurrent MHA 5 years after the procedure was 85% (95% CI 57–97%). Conclusions: The rate of recurrent cerebral ischemia and recurrent MHA seems to be low at long-term follow-up after transcatheter PFO closure. Recurrent cerebral ischemia and relapse of MHA seem to be confined to the first 15 months after the procedure.© 2006 Wiley-Liss, Inc.

Published
2006

48. Transcatheter patent foramen ovale closure mitigates aura migraine headaches abolishing spontaneous right-to-left shunting

Author

Daniela Prandstraller, D. Guidetti, Roberto Formigari, Alessandro Giardini, Oscar Gaddi, Gualtiero Palareti, Fernando M. Picchio, Marco Bonvicini, Andrea Donti, Luisa Salomone, Giardini A, Donti A, Formigari R, Salomone L, Prandstraller D, Bonvicini M, Palareti G, Guidetti D, Gaddi O, and Picchio FM

Subjects
Male, Adult, medicine.medical_specialty, Cardiac Catheterization, Heart Catheterization, Aura, medicine.medical_treatment, Migraine Disorders, Heart Septal Defects, Atrial, Coronary Circulation, Medicine, Humans, Thrombophilia, migraine, Cardiac catheterization, Retrospective Studies, Heart septal defect, business.industry, Retrospective cohort study, Prostheses and Implants, Middle Aged, medicine.disease, Transcranial Doppler, Surgery, Migraine, Patent foramen ovale, Female, Heart Septal Defect, Headaches, medicine.symptom, Cardiology and Cardiovascular Medicine, business
Abstract

Background: Patent foramen ovale (PFO) has been implicated in the etiology of migraine headache with aura (MHA), but the mechanisms that link right-to-left (R-to-L) shunt to MHA are unclear, and the reports on the efficacy of transcatheter PFO closure on MHA prevention are scarce. Methods: We reviewed the clinical records of 131 consecutive patients who underwent successful transcatheter PFO closure at our institution at a mean age of 45 ± 13 years because of cryptogenic stroke. Of the 131 patients, 35 (27%) had a diagnosis of MHA made by the primary care physician or the referring neurologist. Migraine headache with aura incidence and severity were assessed by using Migraine Disability Assessment (MIDAS) questionnaire. Presence and magnitude of R-to-L shunt were assessed in all patients by means of transesophageal echocardiography and also by means of transcranial Doppler (TCD) in the last 50 patients (38%). Results: Patients with MHA had a higher prevalence of thrombophilia (P = .007), a more complex atrial septal anatomy (P = .001), and they also had higher prevalence of spontaneous R-to-L shunt and of spontaneous large shunt, both at transesophageal echocardiography (P = .015, and .028, respectively) and at TCD (P = .036, and .038, respectively). After the procedure, 32 (91%) of 35 patients had either complete resolution or significant improvement in their MHA. At a mean follow-up of 1.7 ± 1.3 years, MHA disappeared completely in 29 (83%) of 35 patients. Of the remaining 6 patients, 3 patients (8%) had an improvement of ≥2 grades in the incidence and severity of MHA, 2 patients did not show any improvement of their MHA, whereas 1 patient reported a severe relapse of MHA about 1 year after the procedure. Conclusions: In patients with PFO, MHA is associated with spontaneous large R-to-L shunt and thrombophilic conditions. Transcatheter defect closure seems to be an effective and safe means to treat MHA in patients with PFO. © 2006, Mosby, Inc. All rights reserved.

Published
2006

49. [Peripheral arteriopathy in ESRD dialysed patients: when and how to intervene]

Author

R, Pacchioni, M, Andreoli, A, Nora, A, Arienzo, M, Tedoli, G, Galli, and D, Guidetti

Subjects
Aged, 80 and over, Male, Peripheral Vascular Diseases, Renal Dialysis, Humans, Kidney Failure, Chronic, Female, Arteries, Middle Aged, Aged, Follow-Up Studies, Retrospective Studies
Abstract

Critical limb ischemia secondary to chronic peripheral occlusive disease is common in chronically dialysed patients, with an incidence rate of 25-30%. Atherosclerotic lesions are more frequent in the infrainguinal arteries and long infrapopliteal occlusions often occur. Due to diabetes, hypertension and ischemic cardiopathy, the surgical prognosis is very poor in these patients; medical treatment should always be attempted associated with analgesia, without an excessive delay in surgical therapy if needed. Both spinal stimulation and lumbar simpaticectomy often fail; open and endovascular surgery are the best options before major amputation, which has a high incidence in this patient subgroup. Between 2000 and 2003, 23 chronically dialysed patients underwent surgery. Nine open and 13 endovascular procedures were performed, associated with four immediate and five late minor amputations. Despite an immediate mortality rate of 8.6%, we obtained immediate patency and limb salvage in all cases. In a medium follow-up of 25 months (range 3-36), five thromboses were found in subinguinal procedures; not one in iliac procedures. The five patients underwent major amputation. Another two patients underwent amputation despite arterious patency. Seven patients died due to cardiovascular diseases during the follow-up. Our experience confirms that the association between POAD and dialysis is a prediction factor for medium-term death and that the surgical risk is highly increased. It is important to select patients undergoing surgical treatment to check for the lowest invasivity.

Published
2005

50. Comparison of results of percutaneous closure of patent foramen ovale for paradoxical embolism in patients with versus without thrombophilia

Author

Roberto Formigari, D. Guidetti, Daniela Prandstraller, Gabriele Bronzetti, Alessandro Giardini, Oscar Gaddi, Fernando M. Picchio, Gualtiero Palareti, Marco Bonvicini, Andrea Donti, GIARDINI A, DONTI A, FORMIGARI R, BRONZETTI G, PRANDSTRALLER D, BONVICINI M, PALARETI G, GUIDETTI D, GADDI O, and PICCHIO F.

Subjects
Adult, Male, medicine.medical_specialty, Percutaneous, Heart disease, Adolescent, Foramen secundum, Thrombophilia, Persistent fetal circulation, Heart Septal Defects, Atrial, Paradoxical embolism, Internal medicine, Coagulopathy, Medicine, Humans, Cardiac Surgical Procedures, business.industry, Middle Aged, medicine.disease, Surgery, Patent foramen ovale, Cardiology, Female, Cardiology and Cardiovascular Medicine, business, Embolism, Paradoxical, Follow-Up Studies
Abstract

We investigated the efficacy of transcatheter patent foramen ovale (PFO) closure to prevent recurrent cerebral ischemic events in patients who did and those who did not have thrombophilia. Patients who have a PFO and an associated thrombophilia may have an increased risk of cerebral ischemic events. Seventy-two consecutive patients (mean age 42 +/- 13 years) underwent percutaneous PFO closure because of a cerebral stroke (51%) or a transient ischemic attack (49%). A thrombophilia was found in 20 patients (28%). A large right-to-left shunt through the PFO was found in 44 patients (61%) and an atrial septal aneurysm was found in 39 (54%). After the first event, 18 of 20 patients (90%) with a thrombophilia received oral anticoagulation. Before closure, patients who had a thrombophilia also had a higher rate of recurrences than patients who did not (p0.0001), despite a similar follow-up (p = 0.14) and regardless of shunt entity (p = 0.59), presence of an atrial septal aneurysm (p = 0.98), and a prevalence of cardiovascular risk factors (p = 0.44). PFO closure was successful in all patients. Five patients (8%) had a residual shunt at 6 months. At 20 +/- 11 months after PFO closure, 3 recurrent events occurred (4%), and the recurrence rate was similar in patients who did and those who did not have a thrombophilia (p = 0.25). Thus, in patients who have a cryptogenic stroke, the association of a PFO with a thrombophilia significantly increases the risk of recurrences. Thus, transcatheter PFO closure is effective for preventing recurrences in patients who have a thrombophilia.

Published
2004

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