Search

Your search keyword '"D. P., Rodrigo"' showing total 4 results
Start Over Author "D. P., Rodrigo"
4 results on '"D. P., Rodrigo"'

2. Stress distribution in the temporomandibular joint affected by anterior disc displacement: a three-dimensional analytic approach with the finite-element method

Author

Kazuo Tanne, Eiji Tanaka, Y Miyawaki, K Lee, D P Rodrigo, and K. Yamaguchi

Subjects
Dental Stress Analysis, Materials science, Compressive Strength, Finite Element Analysis, Joint Dislocations, Mandible, medicine.disease_cause, Models, Biological, Condyle, Bite Force, Weight-bearing, Weight-Bearing, Disc displacement, stomatognathic system, Tensile Strength, Temporomandibular Joint Disc, Ultimate tensile strength, medicine, Humans, General Dentistry, Temporomandibular Joint, Mandibular Condyle, Anatomy, Temporomandibular Joint Disorders, Finite element method, Temporomandibular joint, Bite force quotient, Skull, medicine.anatomical_structure, Stress, Mechanical
Abstract

The purpose of this study was to investigate the influences of anterior disc displacement on TMJ loading during maximum clenching by use of finite-element analysis. Based on a young human dry skull, an analytic model of the mandible including the TMJ was developed. In addition to the standard model with normal disc-condyle relation, two models were designed to simulate various degrees of anterior disc displacement. In the standard model, compressive stresses were induced in the anterior, middle and lateral areas on the condyle and glenoid fossa, whereas tensile stresses were observed in the posterior and medial regions. In the models with anterior disc displacement, compressive stresses were recognized in all the areas of TMJ components excluding the bilaminar zone. Shear stresses in the articular disc and bilaminar zone significantly increased in most areas. In conclusion, stress distributions in the TMJ with a normal disc position was substantially different from those with anterior disc displacement, suggesting that the progress in disc displacement may have some association with the nature of stress distributions in the TMJ, in the articular disc in particular.

Published
2000
Full Text
View/download PDF

4. Biophysical Characterization of the Recombinant Importin- from Neurospora crassa

Author

A. S. Takeda, Agnes, Z. Freitas, Fernanda, J. Magro, Angelo, E. Bernardes, Natalia, A. H. Fernandes, Carlos, D. Goncalves, Rodrigo, Celia Bertolini, Maria, and R. M. Fontes, Marcos

Abstract

Neurospora crassa has been widely used as a model organism and contributed to the development of biochemistry and molecular biology by allowing the identification of many metabolic pathways and mechanisms responsible for gene regulation. Nuclear proteins are synthesized in the cytoplasm and need to be translocated to the nucleus to exert their functions which the importin- receptor has a key role for the classical nuclear import pathway. In an attempt to get structural information of the nuclear transport process in N. crassa, we present herein the cloning, expression, purification and structural studies with N-terminally truncated IMP from N. crassa (IMP-Nc). Circular dichroism analysis revealed that the IMP-Nc obtained is correctly folded and presents a high structural conservation compared to other importins-. Dynamic light scattering, analytical size-exclusion chromatography experiments and molecular dynamics simulations indicated that the IMP-Nc unbound to any ligand may present low stability in solution. The IMP-Nc theoretical model displayed high similarity of its inner concave surface, which binds the cargo proteins containing the nuclear localization sequences, among IMP from different species. However, the presence of non-conserved amino acids relatively close to the NLS binding region may influence the binding specificity of IMP-Nc to cargo proteins.

Published
2013

Catalog

Books, media, physical & digital resources
See catalog results