248 results on '"D. Santangelo"'
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2. Should I Stay or Should I Go?
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Michael J. Mol, Larissa Rabbiosi, and Grazia D. Santangelo
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Geopolitics ,Denmark ,General Engineering ,Operational costs ,Exit strategy ,Reputational costs ,Invasion of Ukraine - Abstract
Geopolitical shifts are having an increased impact on multinational enterprises. We propose a framework that illustrates how corporate responses to geopolitical shifts vary with operational and reputational considerations. We build our framework from evidence of how five Danish multinationals with operations in Russia responded to the Russian invasion of Ukraine. The selected cases highlight several drivers of operational and reputational considerations that offer reasons for MNEs’ heterogeneity in strategic responses. Based on our framework, we derive recommendations for managers in terms of increased preparedness and awareness. We also recommend that policymakers reconsider their strategies for using corporations as geopolitical instruments.
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- 2023
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3. Actionable guidelines to improve ‘theory-related’ contributions to international business research
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Grazia D. Santangelo and Alain Verbeke
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Economics and Econometrics ,Management of Technology and Innovation ,Strategy and Management ,Business and International Management ,General Business, Management and Accounting - Abstract
The editors of most scholarly journals in business and management, including international business (IB) journals such as JIBS, expect authors to make a ‘theory-related’ contribution. Many submissions are rejected outright by the journal’s reviewing editor or after review by field experts because of an insufficient theory-related contribution. In this article, we provide ten actionable guidelines to help authors clarify their theory-related contribution to an extant body of scholarly research, thereby avoiding commonly made mistakes.As a preamble to our ten guidelines, we should like to note that it matters much to frame an empirical phenomenon, a research gap and a research question by using field-specific ‘language’. Appropriate framing means that the author demonstrates adequate knowledge (even when adopting a critical perspective) of the field’s main building blocks, including the shared assumptions and common variables viewed relevant by scholars in the field, to examine a series of phenomena of interest. In the case of IB research, these shared assumptions and variables are related to the purposes and goals of IB activities. Shared assumptions and variables are also related to the characteristics and motivations of the parties involved. These parties include the actors steering the internationally operating firm and those affecting the achievement of its goals, as well as the market and non-market institutions that can influence IB. Finally, shared assumptions and variables are linked to a myriad of outcomes of IB activities, both intended and unintended ones.
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- 2022
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4. Knowledge Sourcing by the Multinational Enterprise
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Anupama Phene and Grazia D. Santangelo
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Economics and Econometrics ,Knowledge management ,Strategy and Management ,media_common.quotation_subject ,International business ,Consistency (negotiation) ,Management of Technology and Innovation ,0502 economics and business ,Economics ,Business and International Management ,Unit level ,Microfoundations ,media_common ,business.industry ,05 social sciences ,Perspective (graphical) ,Creativity ,General Business, Management and Accounting ,Multinational corporation ,International knowledge sourcing ,050211 marketing ,business ,Knowledge transfer ,Componential theory of creativity ,050203 business & management - Abstract
We examine how individual heterogeneity can be managed across geographically dispersed units of the multinational enterprise (MNE) to facilitate effective knowledge sourcing. To explore individual heterogeneity, we adopt the componential theory of creativity, which links heterogeneous features of individuals to creativity performance. We propose that these features shape individuals’ responses to unit-level practices, stimulating international knowledge sourcing and sharing. We further acknowledge that MNE units are subject to the pressures for global integration and local adaptation. Individuals’ responses to unit-level knowledge transfer practices may be inconsistent with one or both of these pressures. We explore, in a nuanced fashion, conditions that can lead to such inconsistencies, and investigate how they can be resolved at the unit level to ensure effective knowledge sourcing by the MNE. Ultimately, our model challenges the assumption that individual knowledge-related efforts automatically accrue to the MNE level. We argue that effective knowledge sourcing by the MNE is the result of successful unit-level processes in managing individual heterogeneity and ensuring consistency with global integration and local adaptation pressures. Our multi-level model contributes to both the MNE- and individual-level perspective on international knowledge sourcing, and the growing microfoundations research on the role of the individual in an MNE.
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- 2022
5. Replication studies in international business
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Luis Alfonso Dau, Arjen van Witteloostuijn, Grazia D. Santangelo, and Ethics, Governance and Society
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Economics and Econometrics ,Economics ,Management of Technology and Innovation ,Strategy and Management ,Knowledge advancement ,International business ,Business and International Management ,General Business, Management and Accounting ,Industrial organization ,Replication (computing) ,Replication studies - Abstract
Dans les affaires internationales, ainsi que dans de nombreux autres domaines des sciences sociales, les recherches de réplication ont longtemps été mal appréciées, découragées et traitées comme parents pauvres et « non originales ». Nous argumentons qu’en élucidant les facteurs de confusion, validant les mécanismes de causalité et testant les limites spatiale et temporelle, les recherches de réplication peuvent stimuler les débats, enrichir notre corpus de connaissances et affiner la théorie. Cet éditorial a pour objectif de promouvoir les recherches de réplication. Nous plaidons en faveur de celles-ci en reconnaissant leurs valeurs et présentant leurs différents types. Nous proposons également un canevas méthodologique permettant de les réaliser avec rigueur académique. Enfin, nous élaborons les recommandations concrètes sur la manière d’augmenter leur nombre de publication., In international business, as well as in many other social sciences, replication studies have long been treated as a poor relative, discounted and discouraged as “not original”. We argue that by teasing out confounding factors, validating causal mechanisms, and testing spatial and temporal boundaries, replication studies can stimulate debate, add to our body of knowledge, and fine-tune theory. Our goal in writing this editorial is to promote replication studies. We build a case for them by recognizing their value and showcasing their different types. We also offer a methodological template for carrying them out with academic rigor. Finally, we make concrete recommendations on how to go about increasing the number of them published.
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- 2022
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6. How cells wrap around virus-like particles using extracellular filamentous protein structures
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Sarthak Gupta, Christian D. Santangelo, Alison E. Patteson, and J. M. Schwarz
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Biological Physics (physics.bio-ph) ,FOS: Biological sciences ,Cell Behavior (q-bio.CB) ,Soft Condensed Matter (cond-mat.soft) ,FOS: Physical sciences ,Quantitative Biology - Cell Behavior ,Physics - Biological Physics ,Condensed Matter - Soft Condensed Matter - Abstract
Nanoparticles, such as viruses, can enter cells via endocytosis. During endocytosis, the cell surface wraps around the nanoparticle to effectively eat it. Prior focus has been on how nanoparticle size and shape impacts endocytosis. However, inspired by the noted presence of extracellular vimentin affecting viral and bacteria uptake, as well as the structure of coronaviruses, we construct a computational model in which both the cell-like construct and the virus-like construct contain filamentous protein structures protruding from their surfaces. We then study the impact of these additional degrees of freedom on viral wrapping. We find that cells with an optimal density of filamentous extracellular components (ECCs) are more likely to be infected as they uptake the virus faster and use relatively less cell surface area per individual virus. At the optimal density, the cell surface folds around the virus, and folds are faster and more efficient at wrapping the virus than crumple-like wrapping. We also find that cell surface bending rigidity helps generate folds, as bending rigidity enhances force transmission across the surface. However, changing other mechanical parameters, such as the stretching stiffness of filamentous ECCs or virus spikes, can drive crumple-like formation of the cell surface. We conclude with the implications of our study on the evolutionary pressures of virus-like particles, with a particular focus on the cellular microenvironment that may include filamentous ECCs., 15 pages, 8 figures
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- 2023
7. EarthScan-TSS, a Cubesat Based Tethered Satellite System And Platform To Test On Orbit Servicing And Space Sustainability
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Andrew D. Santangelo and Gregory Falco
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- 2023
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8. QuickSAT/Designer and /Test, a Flexible and Collaborative AI Based Mission Design and Test Environment
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Andrew D. Santangelo
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- 2023
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9. Making smarter materials
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Christian D, Santangelo
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- 2022
10. Diaspora Ownership and International Technology Licensing by Emerging Market Firms
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Larissa Rabbiosi, Aleksandra Gregoric, and Grazia D. Santangelo
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Economics and Econometrics ,Signaling theory ,Strategy and Management ,Homeland ,International business ,Emerging market firms ,Instrumental variables estimation ,Diaspora ,Market economy ,Management of Technology and Innovation ,0502 economics and business ,Economics ,Matched sample ,Business and International Management ,Emerging markets ,Transaction cost ,05 social sciences ,Liability ,Equity (finance) ,General Business, Management and Accounting ,Liability of origin ,Subnational environments ,International technology licensing ,050211 marketing ,Diaspora ownership ,050203 business & management - Abstract
The liability of origin makes participation in international technology licensing challenging for emerging market firms. We draw on signaling theory to propose that diaspora ownership – diaspora members’ equity investments in their homeland firms – constitutes a reliable third-party signal of emerging market firms’ trustworthiness, which facilitates the access of these firms to international technology licensing. We further hypothesize that the efficacy of diaspora ownership as a third-party signal varies with the firm’s subnational context. Specifically, the relevance of diaspora ownership signal increases with the degree of homogeneity of the within-industry R&D effort in the firm’s sub-national location. This is because, under these conditions, additional signals are required to differentiate between local firms operating in the same industry. In contrast, the diaspora ownership signal has a smaller effect in dysfunctional institutional contexts due to their prohibitive transaction costs. We test our arguments on a matched sample of 597 Indian firms operating between 2006 and 2015, and find general support for the predicted relationships. Our study advances research on the liability of origin of emerging market firms, the work on subnational dimension of international business, and the literature on the benefits diasporans bring to their homelands and resident countries.
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- 2021
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11. Constant spacing in filament bundles
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Daria W Atkinson, Christian D Santangelo, and Gregory M Grason
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filaments and fibers ,packing ,material geometry ,Science ,Physics ,QC1-999 - Abstract
Assemblies of one-dimensional filaments appear in a wide range of physical systems: from biopolymer bundles, columnar liquid crystals, and superconductor vortex arrays; to familiar macroscopic materials, like ropes, cables, and textiles. Interactions between the constituent filaments in such systems are most sensitive to the distance of closest approach between the central curves which approximate their configuration, subjecting these distinct assemblies to common geometric constraints. In this paper, we consider two distinct notions of constant spacing in multi-filament packings in ${{\mathbb{R}}}^{3}$ : equidistance , where the distance of closest approach is constant along the length of filament pairs; and isometry , where the distances of closest approach between all neighboring filaments are constant and equal. We show that, although any smooth curve in ${{\mathbb{R}}}^{3}$ permits one dimensional families of collinear equidistant curves belonging to a ruled surface, there are only two families of tangent fields with mutually equidistant integral curves in ${{\mathbb{R}}}^{3}$ . The relative shapes and configurations of curves in these families are highly constrained: they must be either (isometric) developable domains, which can bend, but not twist; or (non-isometric) constant-pitch helical bundles, which can twist, but not bend. Thus, filament textures that are simultaneously bent and twisted, such as twisted toroids of condensed DNA plasmids or wire ropes, are doubly frustrated: twist frustrates constant neighbor spacing in the cross-section, while non-equidistance requires additional longitudinal variations of spacing along the filaments. To illustrate the consequences of the failure of equidistance, we compare spacing in three ‘almost equidistant’ ansatzes for twisted toroidal bundles and use our formulation of equidistance to construct upper bounds on the growth of longitudinal variations of spacing with bundle thickness.
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- 2019
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12. Controlling the configuration space topology of mechanical structures
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M. Berry, David Limberg, M. E. Lee-Trimble, Ryan Hayward, and C. D. Santangelo
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Linkages are mechanical devices constructed from rigid bars and freely rotating joints studied both for their utility in engineering and as mathematical idealizations in a number of physical systems. Recently, there has been a resurgence of interest in designing linkages in the physics community due to the concurrent developments of mechanical metamaterials, topological mechanics, and the discovery of anomalous rigidity in fiber networks and vertex models. These developments raise a natural question: to what extent can the motion of a linkage or mechanical structure be designed? Here, we describe a method to design the topology of the configuration space of a linkage by first identifying the manifold of critical points, then perturbing around such critical configurations. Unlike other methods, our methods are tractable and provide a simple visual toolkit for mechanism design. We demonstrate our procedure by designing a mechanism to gate the propagation of a soliton in a Kane-Lubensky chain of interconnected rotors.
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- 2022
13. Mechanical signaling cascades
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Michelle Berry, Yongjae Kim, David Limberg, Ryan C. Hayward, and Christian D. Santangelo
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Soft Condensed Matter (cond-mat.soft) ,FOS: Physical sciences ,Condensed Matter - Soft Condensed Matter - Abstract
Mechanical computing has seen resurgent interest recently owing to the potential to embed sensing and computation into new classes of programmable metamaterials. To realize this, however, one must push signals from one part of a device to another, and do so in a way that can be reset robustly. We investigate the propagation of signals in a bistable mechanical cascade uphill in energy. By identifying a penetration length for perturbations, we show that signals can propagate uphill for finite distances and map out parameters for this to occur. Experiments on soft elastomers corroborate our results., 8 pages, 6 figures
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- 2022
14. Theory and practice of origami in science
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Christian D. Santangelo
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Engineering ,business.industry ,0103 physical sciences ,Engineering ethics ,02 engineering and technology ,General Chemistry ,021001 nanoscience & nanotechnology ,010306 general physics ,0210 nano-technology ,Condensed Matter Physics ,business ,01 natural sciences - Abstract
No longer just the purview of artists and enthusiasts, origami engineering has emerged as a potentially powerful tool to create three dimensional structures on disparate scales. Whether origami (and the closely related kirigami) engineering can emerge as a useful technology will depend crucially on both fundamental theoretical advances as well as the development of further fabrication tools.
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- 2020
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15. The relevance of MRI blood-sensitive sequences in the diagnostic assessment of late-onset epilepsy
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S, Neri, M, Ascoli, E, Africa, P, Versace, A, Porcelli, A, Armentano, D, Santangelo, A, Pascarella, L, Manzo, C, Lobianco, G, Mastroianni, V, Cianci, S, Gasparini, U, Aguglia, and E, Ferlazzo
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Cerebral Cortex ,Cerebral Amyloid Angiopathy ,Epilepsy ,Seizures ,Humans ,Magnetic Resonance Imaging - Abstract
Sporadic cerebral amyloid angiopathy (CAA) is a degenerative brain small vessel disease of ageing resulting from progressive amyloid deposition in small arteries and arterioles of the cortex and leptomeninges. CAA may be diagnosed by the mean of Boston criteria, particularly with the use of the blood-sensitive T2* MRI sequences (GRE and SWI). Epileptic seizures have rarely been reported in CAA.We describe two patients with late-onset unprovoked seizures due to CAA. A short literature review on this topic is presented.In our two patients with late-onset unprovoked seizures as the first manifestation of CAA, only GRE and SWI sequences lead to a correct diagnosis. In literature, only 15 patients with CAA presenting with seizures have been reported. In these subjects, data on seizures semiology and prognosis are scarce.Our report highlights the importance to perform blood-sensitive sequences in all subjects with LOE of otherwise unknown etiology, not to miss a diagnosis of CAA.
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- 2022
16. Energetic rigidity. II. Applications in examples of biological and underconstrained materials
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Ojan Khatib Damavandi, Varda F. Hagh, Christian D. Santangelo, and M. Lisa Manning
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Condensed Matter::Soft Condensed Matter ,Condensed Matter - Materials Science ,Biological Physics (physics.bio-ph) ,Soft Condensed Matter (cond-mat.soft) ,Materials Science (cond-mat.mtrl-sci) ,FOS: Physical sciences ,Disordered Systems and Neural Networks (cond-mat.dis-nn) ,Physics - Biological Physics ,Condensed Matter - Soft Condensed Matter ,Condensed Matter - Disordered Systems and Neural Networks - Abstract
This is the second paper devoted to energetic rigidity, in which we apply our formalism to examples in two dimensions: underconstrained random regular spring networks, vertex models, and jammed packings of soft particles. Spring networks and vertex models are both highly underconstrained, and first-order constraint counting does not predict their rigidity, but second-order rigidity does. In contrast, spherical jammed packings are overconstrained and thus first-order rigid, meaning that constraint counting is equivalent to energetic rigidity as long as prestresses in the system are sufficiently small. Aspherical jammed packings on the other hand have been shown to be jammed at hypostaticity, which we use to argue for a modified constraint counting for systems that are energetically rigid at quartic order., 13 pages, 8 figures. Second of a two-part series
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- 2022
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17. Epilepsy in Cerebrovascular Diseases: A Narrative Review
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U. Aguglia, S. Neri, S. Gasparini, A. Pascarella, D. Santangelo, V. Cianci, A. Mammì, M. Lo Giudice, and E. Ferlazzo
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Pharmacology ,Psychiatry and Mental health ,Neurology ,Pharmacology (medical) ,Neurology (clinical) ,General Medicine - Abstract
Background: Epilepsy is a common comorbidity of cerebrovascular disease and an increasing socioeconomic burden. Objective: Objective: We aimed to provide an updated comprehensive review on the state of the art about seizures and epilepsy in stroke, cerebral haemorrhage, and leukoaraiosis. Methods: We selected English-written articles on epilepsy, stroke, and small vessel disease up until December 2021. We reported the most recent data about epidemiology, pathophysiology, prognosis, and management for each disease. Results: The main predictors for both ES and PSE are the severity and extent of stroke, the presence of cortical involvement and hemorrhagic transformation, while PSE is also predicted by younger age at stroke onset. Few data exist on physiopathology and seizure semiology, and no randomized controlled trial has been performed to standardize the therapeutic approach to post-stroke epilepsy. Conclusion: Some aspects of ES and PSE have been well explored, particularly epidemiology and risk factors. On the contrary, few data exist on physiopathology, and existing evidence is mainly based on studies on animal models. Little is also known about seizure semiology, which may also be difficult to interpret by non-epileptologists. Moreover, the therapeutic approach needs standardization as regards indications and the choice of specific ASMs. Future research may help to better elucidate these aspects.
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- 2022
18. The LinkStar Cybersecurity 'Sandbox', a platform to test small satellite vulnerabilities within the Community – Updates and Lessons Learned
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Andrew D. Santangelo, Gregory Falco, and Arun Viswanathan
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- 2022
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19. Subsidiary Technological Scope and Learning
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Anupama Phene and Grazia D. Santangelo
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This chapter examines the role of foreign subsidiary technological scope in the learning process that culminates in MNE innovation. It explores how subsidiary scope, reflected in the dispersion of its technological activity, operates across different stages of the learning process. To develop the arguments, insights on specialists and generalists from organizational research are integrated with research on firm reasoning. The authors posit that search and extension stages involve unpredictable environments that create an advantage for generalist subsidiaries who can engage in analogical reasoning by drawing on a wider variety of familiar chunks of knowledge. In contrast, access and integration stages create predictable learning environments where specialized subsidiaries are in an advantageous position, with access to fewer but deeper chunks of knowledge resulting in effective learning. Futhermore, theoretical and managerial implications for the cross-border organization of MNE innovation are developed to present a more nuanced view of the role of the subsidiary.
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- 2022
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20. Spring 2021 Flight Of The LinkStar-TRK System On A CubeSat
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Andrew D. Santangelo
- Subjects
Meteorology ,Trk receptor ,CubeSat ,Spring (mathematics) ,Geology - Published
- 2021
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21. QuickSAT/Designer, a Flexible and Collaborative AI Based Mission Design Environment For New Space
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Andrew D. Santangelo
- Subjects
Mission design ,Computer science ,Systems engineering ,Space (commercial competition) - Published
- 2021
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22. The LinkStar Cybersecurity 'Sandbox' - a platform to test cubesat vulnerabilities within the Small Satellite Community
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Andrew D. Santangelo
- Subjects
Computer science ,Sandbox (computer security) ,Vulnerability ,Satellite ,CubeSat ,Computer security ,computer.software_genre ,computer ,Test (assessment) - Published
- 2021
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23. The STX4/SpotX Radio System: An Evolution From Global Simplex To Global Duplex Communications for 1U Cubesats And Larger Vehicles
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Andrew D. Santangelo
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Simplex ,Computer science ,business.industry ,Duplex (telecommunications) ,Radio system ,business ,Computer hardware - Published
- 2021
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24. The significance of European small country regions in the geographical division of labour of European Information and Communications Technology (ICT) corporations.
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John Cantwell and Grazia D. Santangelo
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- 2002
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25. Apolipoprotein Mimetic Peptide Inhibits Neutrophil-Driven Inflammatory Damage via Membrane Remodeling and Suppression of Cell Lysis
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Michelle W. Lee, Kiyotaka Akabori, Nathan W. Schmidt, Carlos Silvestre-Roig, Elizabeth Wei Chia Luo, Yashes Srinivasan, Gerard C. L. Wong, Christian D. Santangelo, Ghee Hwee Lai, Patricia Lemnitzer, and Oliver Soehnlein
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Programmed cell death ,biology ,Cell Death ,Chemistry ,Neutrophils ,General Engineering ,General Physics and Astronomy ,Inflammation ,Neutrophil extracellular traps ,Extracellular Traps ,Article ,Cell biology ,Histone H4 ,Histones ,Histone ,Lytic cycle ,medicine ,biology.protein ,Extracellular ,General Materials Science ,medicine.symptom ,Cytotoxicity ,Peptides - Abstract
Neutrophils are crucial for host defense but are notorious for causing sterile inflammatory damage. Activated neutrophils in inflamed tissue can liberate histone H4, which was recently shown to perpetuate inflammation by permeating membranes via the generation of negative Gaussian curvature (NGC), leading to lytic cell death. Here, we show that it is possible to build peptides or proteins that cancel NGC in membranes and thereby suppress pore formation, and demonstrate that they can inhibit H4 membrane remodeling and thereby reduce histone H4-driven lytic cell death and resultant inflammation. As a demonstration of principle, we use apolipoprotein A-I (apoA-I) mimetic peptide apoMP(1). X-ray structural studies and theoretical calculations show that apoMP(1) induces nanoscopic positive Gaussian curvature (PGC), which interacts with the NGC induced by the N-terminus of histone H4 (H4n) to inhibit membrane permeation. Interestingly, we show that induction of PGC can inhibit membrane-permeating activity in general and “turn off” diverse membrane-permeating molecules besides H4n. In vitro experiments show an apoMP(1) dose-dependent rescue of H4 cytotoxicity. Using a mouse model, we show that tissue accumulation of neutrophils, release of neutrophil extracellular traps (NETs), and extracellular H4 all strongly correlate independently with local tissue cell death in multiple organs, but administration of apoMP(1) inhibits histone H4-mediated cytotoxicity and strongly prevents organ tissue damage.
- Published
- 2021
26. An inactivated enterovirus 71 vaccine is safe and immunogenic in healthy adults: A phase I, double blind, randomized, placebo-controlled, study of two dosages
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Raman Rao, Paul A. Tambyah, Lovkesh Karwal, Hansi Dean, Jolene Oon, William Kristanto, Joseph D. Santangelo, Shi-Hsia Hwa, Fue Vang, Subash C. Das, Jeremy Fuchs, Rosmonaliza Asli, Dan T. Stinchcomb, Cynthia A. Thomson, and Gilad Gordon
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Adult ,Male ,medicine.medical_specialty ,Dose ,Cross Protection ,030231 tropical medicine ,Placebo-controlled study ,Antibodies, Viral ,Placebo ,Young Adult ,03 medical and health sciences ,Immunogenicity, Vaccine ,0302 clinical medicine ,Neutralization Tests ,Internal medicine ,Outcome Assessment, Health Care ,Enterovirus Infections ,medicine ,Enterovirus 71 ,Humans ,030212 general & internal medicine ,Seroconversion ,Adverse effect ,Reactogenicity ,General Veterinary ,General Immunology and Microbiology ,biology ,business.industry ,Vaccination ,Public Health, Environmental and Occupational Health ,Viral Vaccines ,Middle Aged ,biology.organism_classification ,Antibodies, Neutralizing ,Healthy Volunteers ,Enterovirus A, Human ,Infectious Diseases ,Vaccines, Inactivated ,Molecular Medicine ,Female ,business - Abstract
Background Hand, foot and mouth disease (HFMD), especially that caused by enterovirus 71 (EV71) infection, is a public health concern in the Asia-Pacific region. We report a phase I clinical trial of an EV71 candidate vaccine (INV21) based on a binary ethylenimine inactivated B2 sub-genotype formulated with aluminum hydroxide. Methods In this double-blind, placebo-controlled, randomized, dose escalation study adult volunteers received two vaccinations 28 days apart of low or high dose formulations of the candidate vaccine and were then monitored for safety and reactogenicity for four weeks after each dose, and for their immune responses up to 28 weeks. Results Of 36 adults enrolled, 35 completed the study as planned. Either no or mild adverse events were observed, mainly injection site pain and tiredness. Seroconversion was 100% after two vaccinations. High geometric mean neutralizing antibody titers (GMT) were observed 14 days post first dose, peaking 14 days post second dose (at Day 42) in both high and low dose groups; GMTs on days 14, 28, 42, and 56 were 128, 81, 323, 203 and 144, 100, 451, 351 in low- and high-dose groups, respectively. Titers for both doses declined gradually to Day 196 but remained higher than baseline and the placebo groups, which had low GMTs throughout the duration of the study. Cross-neutralizing antibody activity against heterologous sub-genotypes was demonstrated. Conclusion These data show that the EV71 candidate vaccine is safe and immunogenic in adults and supports further clinical development as a potential pediatric vaccine by initiating a dose-escalation study for determining the dose-dependent safety and immunogenicity of the vaccine in young naive children.
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- 2019
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27. MNEs’ location strategies and labor standards: The role of operating and reputational considerations across industries
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Seda Koymen-Ozer, Grazia D. Santangelo, and Daniela Maggioni
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Economics and Econometrics ,liability of foreignness ,Strategy and Management ,05 social sciences ,reputational costs ,Developing country ,International business ,General Business, Management and Accounting ,Occupational safety and health ,industry specificities ,labor standards ,location choice ,Bargaining power ,Management of Technology and Innovation ,0502 economics and business ,Economics ,Settore SECS-P/08 - ECONOMIA E GESTIONE DELLE IMPRESE ,050211 marketing ,Business and International Management ,Settore SECS-P/01 - Economia Politica ,050203 business & management ,Industrial organization - Abstract
We investigate the role of local labor standards on MNEs’ location decisions across different sectors and sub-national regions within a developing country. We suggest that foreign investors adopt selective location strategies in connection with specific labor standards as a result of reputational and operating considerations. Foreign firms in more hazardous sectors prefer locations with higher occupational health and safety standards because they are more exposed to reputational risks. Those in sectors with less reversible investments prefer locations with lower degrees of unionization because their lower bargaining power increases their sensitivity to operating costs. We test our arguments across 26 sub-national Turkish regions over the period 2005–2011.
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- 2019
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28. International Business and Human Rights
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Grazia D. Santangelo, Günter K. Stahl, Elisa Giuliani, and Florian Wettstein
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Business and human rights ,Corporate social responsibility ,Multinational Enterprise ,Sustainability ,media_common.quotation_subject ,International business ,Political science ,0502 economics and business ,Business and International Management ,media_common ,Marketing ,Human rights ,business.industry ,Field (Bourdieu) ,05 social sciences ,Public relations ,Scholarship ,Multinational corporation ,Thriving ,050211 marketing ,business ,050203 business & management ,Finance - Abstract
The discussion on business responsibilities for human rights is thriving – although, surprisingly, predominantly outside of the International Business (IB) field. This article introduces business and human rights (BHR) as a research area with great potential for IB scholars. IB scholarship has much to offer when it comes to better understanding the relation between multinational enterprises (MNEs) and human rights. BHR, on the other hand, is a field that can no longer be ignored by IB research if the field is to remain at the forefront of scholarship in globalization-related issues concerning MNEs. Therefore, this perspective article aims at providing guidance to IB scholars interested in engaging in BHR research by tracing common themes and overlaps, and outlining a research agenda that addresses some of the research gaps and open questions in both fields.
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- 2019
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29. Energetic rigidity. I. A unifying theory of mechanical stability
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Ojan Khatib Damavandi, Varda F. Hagh, Christian D. Santangelo, and M. Lisa Manning
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Condensed Matter - Materials Science ,Biological Physics (physics.bio-ph) ,Soft Condensed Matter (cond-mat.soft) ,Materials Science (cond-mat.mtrl-sci) ,FOS: Physical sciences ,Disordered Systems and Neural Networks (cond-mat.dis-nn) ,Physics - Biological Physics ,Condensed Matter - Soft Condensed Matter ,Condensed Matter - Disordered Systems and Neural Networks - Abstract
Rigidity regulates the integrity and function of many physical and biological systems. This is the first of two papers on the origin of rigidity, wherein we propose that "energetic rigidity," in which all non-trivial deformations raise the energy of a structure, is a more useful notion of rigidity in practice than two more commonly used rigidity tests: Maxwell-Calladine constraint counting (first-order rigidity) and second-order rigidity. We find that constraint counting robustly predicts energetic rigidity only when the system has no states of self stress. When the system has states of self stress, we show that second-order rigidity can imply energetic rigidity in systems that are not considered rigid based on constraint counting, and is even more reliable than shear modulus. We also show that there may be systems for which neither first nor second-order rigidity imply energetic rigidity. The formalism of energetic rigidity unifies our understanding of mechanical stability and also suggests new avenues for material design., 14 pages, 2 figures. First of a two-part series
- Published
- 2021
30. Robust Folding of Elastic Origami
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M. E. Lee-Trimble, Ji-Hwan Kang, Ryan C. Hayward, and Christian D. Santangelo
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Soft Condensed Matter (cond-mat.soft) ,FOS: Physical sciences ,General Chemistry ,Condensed Matter - Soft Condensed Matter ,Condensed Matter Physics ,Elasticity - Abstract
Self-folding origami, structures that are engineered flat to fold into targeted, three-dimensional shapes, have many potential engineering applications. Though significant effort in recent years has been devoted to designing fold patterns that can achieve a variety of target shapes, recent work has also made clear that many origami structures exhibit multiple folding pathways, with a proliferation of geometric folding pathways as the origami structure becomes complex. The competition between these pathways can lead to structures that are programmed for one shape, yet fold incorrectly. To disentangle the features that lead to misfolding, we introduce a model of self-folding origami that accounts for the finite stretching rigidity of the origami faces and allows the computation of energy landscapes that lead to misfolding. We find that, in addition to the geometrical features of the origami, the finite elasticity of the nearly-flat origami configurations regulates the proliferation of potential misfolded states through a series of saddle-node bifurcations. We apply our model to one of the most common origami motifs, the symmetric "bird's foot," a single vertex with four folds. We show that though even a small error in programmed fold angles induces metastability in rigid origami, elasticity allows one to tune resilience to misfolding. In a more complex design, the "Randlett flapping bird," which has thousands of potential competing states, we further show that the number of actual observed minima is strongly determined by the structure's elasticity. In general, we show that elastic origami with both stiffer folds and less bendable faces self-folds better.
- Published
- 2021
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31. Mechanics of metric frustration in contorted filament bundles: From local symmetry to columnar elasticity
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Daria W. Atkinson, Gregory M. Grason, and Christian D. Santangelo
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Physics ,Quantitative Biology::Biomolecules ,media_common.quotation_subject ,General Physics and Astronomy ,Frustration ,Proteins ,FOS: Physical sciences ,Mechanics ,Bending ,Condensed Matter - Soft Condensed Matter ,01 natural sciences ,Symmetry (physics) ,Elasticity ,010305 fluids & plasmas ,Protein filament ,Quantitative Biology::Subcellular Processes ,Local symmetry ,Bundle ,0103 physical sciences ,Metric (mathematics) ,Soft Condensed Matter (cond-mat.soft) ,Elasticity (economics) ,010306 general physics ,media_common - Abstract
Bundles of filaments are subject to geometric frustration: certain deformations (e.g. bending while twisted) require longitudinal variations in spacing between filaments. While bundles are common -- from protein fibers to yarns -- the mechanical consequences of longitudinal frustration are unknown. We derive a geometrically-nonlinear formalism for bundle mechanics, using a gauge-like symmetry under reptations along filament backbones. We relate force balance to orientational geometry and assess the elastic cost of frustration in twisted toroidal bundles., Comment: 9 pages, 3 figures
- Published
- 2021
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32. Thermal Fluctuations of Singular Bar-Joint Mechanisms
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Manu Mannattil, J. M. Schwarz, and Christian D. Santangelo
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Chemical Physics (physics.chem-ph) ,Hot Temperature ,Statistical Mechanics (cond-mat.stat-mech) ,Physics - Chemical Physics ,Statistics as Topic ,General Physics and Astronomy ,Soft Condensed Matter (cond-mat.soft) ,FOS: Physical sciences ,Condensed Matter - Soft Condensed Matter ,Condensed Matter - Statistical Mechanics - Abstract
A bar-joint mechanism is a deformable assembly of freely rotating joints connected by stiff bars. Here we develop a formalism to study the equilibration of common bar-joint mechanisms with a thermal bath. When the constraints in a mechanism cease to be linearly independent, singularities can appear in its shape space, which is the part of its configuration space after discarding rigid motions. We show that the free-energy landscape of a mechanism at low temperatures is dominated by the neighborhoods of points that correspond to these singularities. We consider two example mechanisms with shape-space singularities and find that they are more likely to be found in configurations near the singularities than others. These findings are expected to help improve the design of nanomechanisms for various applications., Comment: 6 + 21 pages; 3 + 7 figures
- Published
- 2021
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33. Topology in non-linear mechanical systems
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Christian D. Santangelo, Po Wei Lo, Bryan Gin-ge Chen, Chao-Ming Jian, Krishanu Roychowdhury, and Michael J. Lawler
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Physics ,Linear system ,General Physics and Astronomy ,FOS: Physical sciences ,Field (mathematics) ,Type (model theory) ,Condensed Matter - Soft Condensed Matter ,Topology ,01 natural sciences ,010305 fluids & plasmas ,Nonlinear system ,Differential geometry ,Topological index ,0103 physical sciences ,Soft Condensed Matter (cond-mat.soft) ,Invariant (mathematics) ,010306 general physics ,Topology (chemistry) - Abstract
Many advancements have been made in the field of topological mechanics. The majority of the work, however, concerns the topological invariant in a linear theory. In this Letter, we present a generic prescription to define topological indices that accommodates nonlinear effects in mechanical systems without taking any approximation. Invoking the tools of differential geometry, a $\mathbb{Z}$-valued quantity in terms of a topological index in differential geometry known as the Poincar\'e-Hopf index, which features the topological invariant of nonlinear zero modes (ZMs), is predicted. We further identify one type of topologically protected solitons that are robust to disorders. Our prescription constitutes a new direction of searching for novel topologically protected nonlinear ZMs in the future.
- Published
- 2021
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34. Preclinical evaluation of the immunogenicity and safety of an inactivated enterovirus 71 candidate vaccine.
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Shi-Hsia Hwa, Yock Ann Lee, Joseph N Brewoo, Charalambos D Partidos, Jorge E Osorio, and Joseph D Santangelo
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Arctic medicine. Tropical medicine ,RC955-962 ,Public aspects of medicine ,RA1-1270 - Abstract
Human enterovirus 71 (EV71) is a significant cause of morbidity and mortality from Hand, Foot and Mouth Disease (HFMD) and neurological complications, particularly in young children in the Asia-Pacific region. There are no vaccines or antiviral therapies currently available for prevention or treatment of HFMD caused by EV71. Therefore, the development of therapeutic and preventive strategies against HFMD is of growing importance. We report the immunogenic and safety profile of inactivated, purified EV71 preparations formulated with aluminum hydroxide adjuvant in preclinical studies in mice and rabbits. In mice, the candidate vaccine formulations elicited high neutralizing antibody responses. A toxicology study of the vaccine formulations planned for human use performed in rabbits showed no vaccine-related pathological changes and all animals remained healthy. Based on these preclinical studies, Phase 1 clinical testing of the EV71 inactivated vaccine was initiated.
- Published
- 2013
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35. Adaptation of enterovirus 71 to adult interferon deficient mice.
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Elizabeth A Caine, Charalambos D Partidos, Joseph D Santangelo, and Jorge E Osorio
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Medicine ,Science - Abstract
Non-polio enteroviruses, including enterovirus 71 (EV71), have caused severe and fatal cases of hand, foot and mouth disease (HFMD) in the Asia-Pacific region. The development of a vaccine or antiviral against these pathogens has been hampered by the lack of a reliable small animal model. In this study, a mouse adapted EV71 strain was produced by conducting serial passages through A129 (α/β interferon (IFN) receptor deficient) and AG129 (α/β, γ IFN receptor deficient) mice. A B2 sub genotype of EV71 was inoculated intraperitoneally (i.p.) into neonatal AG129 mice and brain-harvested virus was subsequently passaged through 12 and 15 day-old A129 mice. When tested in 10 week-old AG129 mice, this adapted strain produced 100% lethality with clinical signs including limb paralysis, eye irritation, loss of balance, and death. This virus caused only 17% mortality in same age A129 mice, confirming that in the absence of a functional IFN response, adult AG129 mice are susceptible to infection by adapted EV71 isolates. Subsequent studies in adult AG129 and young A129 mice with the adapted EV71 virus examined the efficacy of an inactivated EV71 candidate vaccine and determined the role of humoral immunity in protection. Passive transfer of rabbit immune sera raised against the EV71 vaccine provided protection in a dose dependent manner in 15 day-old A129 mice. Intramuscular injections (i.m.) in five week-old AG129 mice with the alum adjuvanted vaccine also provided protection against the mouse adapted homologous strain. No clinical signs of disease or mortality were observed in vaccinated animals, which received a prime-and-boost, whereas 71% of control animals were euthanized after exhibiting systemic clinical signs (P
- Published
- 2013
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36. Internationalization Process Perspective
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Grazia D. Santangelo
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MNE performance ,Managerial roles ,IP model ,Internationalization ,Process management ,International knowledge acquisition ,Process (engineering) ,Perspective (graphical) ,Internationalization dynamics ,Path-breaking commitment ,Business ,Market knowledge speed - Abstract
To manage the increasing competition in their home markets, firms need to go international and seek new markets, improve their efficiency, acquire natural resources, and (or) gain access to strategic assets. Irrespective of the motivations driving the decision to cross national boundaries, firms face the challenge to plan their internationalization process (IP) effectively. This chapter offers an overview of the IP perspective starting from the original formulation of the IP—or Uppsala— model (Johanson & Vahlne, 1977) to its latest revision (Vahlne & Johanson, 2017) and the open-ended debate that this revision continues to stimulate. It then discusses how firms acquire market knowledge for the first-time versus subsequent internationalization, and why they may change their market commitment after the initial foreign market entry.
- Published
- 2020
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37. Hidden symmetries generate rigid folding mechanisms in periodic origami
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D. Zeb Rocklin, Bryan Gin-ge Chen, James McInerney, Christian D. Santangelo, Louis Theran, and University of St Andrews. Pure Mathematics
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T-NDAS ,FOS: Physical sciences ,02 engineering and technology ,Condensed Matter - Soft Condensed Matter ,Computer Science::Computational Geometry ,01 natural sciences ,Origami ,symbols.namesake ,0103 physical sciences ,Gaussian curvature ,Mechanisms ,Wavenumber ,QA Mathematics ,Topological polarization ,010306 general physics ,QA ,Rigid folding ,Physics ,Multidisciplinary ,Computer simulation ,021001 nanoscience & nanotechnology ,Rigid body ,T Technology ,Classical mechanics ,Pairing ,Homogeneous space ,Physical Sciences ,symbols ,Soft Condensed Matter (cond-mat.soft) ,Configuration space ,0210 nano-technology ,Atiyah–Singer index theorem - Abstract
Funding: NSF Award No. PHY-1554887 (B.G.C.). NSF DMR-1822638 (C.S.). Georgia Institute of Technology President’s Fellowship and the STAMI Graduate Student Fellowship ( J.M.). We consider the zero-energy deformations of periodic origami sheets with generic crease patterns. Using a mapping from the linear folding motions of such sheets to force-bearing modes in conjunction with the Maxwell–Calladine index theorem we derive a relation between the number of linear folding motions and the number of rigid body modes that depends only on the average coordination number of the origami’s vertices. This supports the recent result by Tachi [T. Tachi, Origami 6, 97–108 (2015)] which shows periodic origami sheets with triangular faces exhibit two-dimensional spaces of rigidly foldable cylindrical configurations. We also find, through analytical calculation and numerical simulation, branching of this configuration space from the flat state due to geometric compatibility constraints that prohibit finite Gaussian curvature. The same counting argument leads to pairing of spatially varying modes at opposite wavenumber in triangulated origami, preventing topological polarization but permitting a family of zero-energy deformations in the bulk that may be used to reconfigure the origami sheet. Postprint
- Published
- 2020
38. LinkStar-TRK - A PC104 Based Integrated Computer Architecture, Communications and Global Tracking System for CubeSats
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Andrew D. Santangelo
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Computer architecture ,Computer science ,business.industry ,Tracking system ,business - Published
- 2020
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39. QuickSAT/Autonomy - an open Autonomy Framework for Cubesats and Small Satellites
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Andrew D. Santangelo
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business.industry ,media_common.quotation_subject ,Telecommunications ,business ,Autonomy ,media_common - Published
- 2020
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40. A positive PSMA PET/CT predicts more aggressive disease progression in patients with biochemical recurrence after radical prostatectomy
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Andrea Gallina, P.I. Karakiewicz, M. Moschini, Francesco Montorsi, Vito Cucchiara, Luigi Nocera, Alberto Martini, Armando Stabile, A. Rizzo, E. Zito, Francesco Barletta, A. Briganti, C.A. Bravi, Simone Scuderi, Matteo Droghetti, Gabriele Sorce, G. Gandaglia, D. Santangelo, F. Pellegrino, E. Mazzone, N. Fossati, Daniele Robesti, L. Sciacqua, and E. Camisassa
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Biochemical recurrence ,medicine.medical_specialty ,Prostatectomy ,business.industry ,Urology ,medicine.medical_treatment ,Aggressive disease ,lcsh:Diseases of the genitourinary system. Urology ,lcsh:RC870-923 ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,lcsh:RC254-282 ,medicine ,In patient ,Psma pet ct ,business - Published
- 2020
41. Host country corruption and the organization of HQ–subsidiary relationships
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Grazia D. Santangelo and Larissa Rabbiosi
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Economics and Econometrics ,Corruption ,Strategy and Management ,media_common.quotation_subject ,Subsidiary ,Subsidiary autonomy ,International business ,Foreign direct investment ,Market economy ,Headquarters–subsidiary relations ,Management of Technology and Innovation ,0502 economics and business ,Economics ,Business and International Management ,Legitimacy ,media_common ,Dissociation strategy ,05 social sciences ,General Business, Management and Accounting ,Multinational corporation ,050211 marketing ,Organizational perspective of corruption ,050203 business & management ,Autonomy ,Reputation - Abstract
Multinational enterprises (MNEs) operating in more corrupt host (than home) countries face actual costs related to processing information for decision-making, and lack of local legitimacy, and potential reputation and legal costs in case of corruption scandals. Drawing on the organizational perspective of corruption, we argue that greater subsidiary autonomy helps minimize these costs. However, headquarter (HQ)–subsidiary communication weakens the autonomy-based advantages for minimizing legitimacy costs, and MNEs’ experience in relatively corrupt countries weakens the advantages for minimizing information-processing costs. Our analysis of 261 Italian foreign subsidiaries in 25 host countries confirms most of our arguments except the moderating effect of MNE experience. Our findings contribute to research on corruption and FDI, weak institutional contexts and MNE strategies as well as the literature on HQ–subsidiary relationship.
- Published
- 2018
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42. Topological kinematics of origami metamaterials
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Thomas C. Hull, Itai Cohen, Bin Liu, Arthur A. Evans, Robert J. Lang, Jesse L. Silverberg, and Christian D. Santangelo
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Physics ,Bistability ,General Physics and Astronomy ,Metamaterial ,Fermi surface ,02 engineering and technology ,Kinematics ,021001 nanoscience & nanotechnology ,Topology ,01 natural sciences ,0103 physical sciences ,Configuration space ,Variety (universal algebra) ,010306 general physics ,0210 nano-technology ,Topology (chemistry) - Abstract
A variety of electronic phases in solid-state systems can be understood by abstracting away microscopic details and refocusing on how Fermi surface topology interacts with band structure to define available electron states1. In fact, topological concepts are broadly applicable to non-electronic materials and can be used to understand a variety of seemingly unrelated phenomena2–6. Here, we apply topological principles to origami-inspired mechanical metamaterials7–12, and demonstrate how to guide bulk kinematics by tailoring the crease configuration-space topology. Specifically, we show that by simply changing the crease angles, we modify the configuration-space topology, and drive origami structures to dramatically change their kinematics from being smoothly and continuously deformable to mechanically bistable and rigid. In addition, we examine how a topologically disjointed configuration space can be used to constrain the locally accessible deformations of a single folded sheet. While analyses of origami structures are typically dependent on the energetics of constitutive relations11–14, the topological abstractions introduced here are a separate and independent consideration that we use to analyse, understand and design these metamaterials. Origami-inspired metamaterial design gives rise to structures with kinematic properties dictated by the topology of their configuration space. The approach allows for well-defined metamaterial properties even in the presence of unpredictable forces.
- Published
- 2018
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43. Guest editorial
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Grazia D. Santangelo
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Set (abstract data type) ,Multinational corporation ,0502 economics and business ,05 social sciences ,Regional science ,Business ,050207 economics ,Business and International Management ,General Business, Management and Accounting ,050203 business & management - Published
- 2018
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44. Internationalization through exaptation: The role of domestic geographical dispersion in the internationalization process
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Grazia D. Santangelo and Tamara Stucchi
- Subjects
Economics and Econometrics ,Process (engineering) ,business.industry ,Strategy and Management ,05 social sciences ,Control (management) ,Context (language use) ,Exaptation ,International business ,General Business, Management and Accounting ,Internationalization ,Management of Technology and Innovation ,0502 economics and business ,Organizational learning ,Economics ,Frame (artificial intelligence) ,Economic geography ,050207 economics ,Business and International Management ,business ,050203 business & management - Abstract
We introduce the notion of exaptation to internationalization theory, a process in which a capability is re-used for a purpose and in a context different than its historical purpose and context. Specifically, we examine which domestic capabilities may be redeployed when organizations engage in cross-border M&As for the first time. We suggest that organizations exapt (re-use) coordination and control capabilities, initially developed to manage domestic geographical dispersion, to acquire and integrate external resources across borders. By analyzing 693 Indian business groups over a decade, we add to the recent effort to frame the internationalization process within evolutionary theory.
- Published
- 2018
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45. Location, collocation and innovation by multinational enterprises: a research agenda
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Ram Mudambi, Grazia D. Santangelo, and Rajneesh Narula
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Collocation ,business.industry ,media_common.quotation_subject ,05 social sciences ,Distribution (economics) ,International business ,Space (commercial competition) ,Creativity ,General Business, Management and Accounting ,Multinational corporation ,Management of Technology and Innovation ,0502 economics and business ,Economic geography ,050207 economics ,business ,Nexus (standard) ,050203 business & management ,Disadvantage ,media_common - Abstract
The distribution of creative economic activity over space has been viewed from three distinct perspectives. International business focuses on the multinational enterprise and the location of activities across national borders; economic geography studies the characteristics of the location site; and innovation scholars are mainly concerned with the technologies and knowledge that arises from the interaction of location and the creativity of actors. All these communities have drawn attention to collocation. However, the nexus of the three literatures is surprisingly thin, in particular with regard to the conditions under which collocation is an advantage or a disadvantage. In this paper, we take stock of the knowledge developed by the three communities and move the discussion further by qualifying a number of these conditions. Based on these considerations, we then propose a number of directions for future research.
- Published
- 2018
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46. The seroprevalence and seroincidence of enterovirus71 infection in infants and children in Ho Chi Minh City, Viet Nam.
- Author
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Chau Bich Nguyen Tran, Hieu Trong Nguyen, Ha Thanh Thi Phan, Ngoc Van Tran, Bridget Wills, Jeremy Farrar, Joseph D Santangelo, and Cameron P Simmons
- Subjects
Medicine ,Science - Abstract
Enterovirus 71 (EV71)-associated hand, foot and mouth disease has emerged as a serious public health problem in South East Asia over the last decade. To better understand the prevalence of EV71 infection, we determined EV71 seroprevalence and seroincidence amongst healthy infants and children in Ho Chi Minh City, Viet Nam. In a cohort of 200 newborns, 55% of cord blood samples contained EV71 neutralizing antibodies and these decayed to undetectable levels by 6 months of age in 98% of infants. The EV71 neutralizing antibody seroconversion rate was 5.6% in the first year and 14% in the second year of life. In children 5-15 yrs of age, seroprevalence of EV71 neutralizing antibodies was 84% and in cord blood it was 55%. Taken together, these data suggest EV71 force of infection is high and highlights the need for more research into its epidemiology and pathogenesis in high disease burden countries.
- Published
- 2011
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47. Refugee Human Capital and Firm Performance
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Grazia D. Santangelo, Wolfgang Sofka, and Vera Rocha
- Subjects
Extant taxon ,Refugee ,Political science ,Refugee crisis ,Development economics ,Management research ,General Medicine ,Human capital - Abstract
The availability of employment is a central determinant for addressing the refugee crisis in many host countries. Extant management research largely assumes that hiring refugees is part of firms’ s...
- Published
- 2021
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- View/download PDF
48. The evolution of strategic asset-seeking acquisitions by emerging market multinationals
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Stefano Elia and Grazia D. Santangelo
- Subjects
Marketing ,Strategic asset allocation ,Strategic asset-seeking acquisitions, Emerging market multinationals, National innovation system, Industry context ,Strategic asset-seeking acquisitions ,Industry context ,05 social sciences ,Context (language use) ,National innovation system ,Market economy ,Multinational corporation ,0502 economics and business ,Emerging market multinationals ,050211 marketing ,Business ,Business and International Management ,Emerging markets ,050203 business & management ,Finance ,Industrial organization - Abstract
We study the extent to which emerging market multinational enterprises (EMNEs) engage in strategic asset-seeking acquisitions in advanced countries in relation to the strength of their home- and host-country national innovation system (NIS). We suggest that early acquisitions by EMNEs were used to compensate for the EMNEs relatively weak home NIS, and targeted weaker host NIS to limit the cognitive gap EMNEs would need to address. Instead, more recent acquisitions by EMNEs are supported by a stronger home NIS, and target firms in stronger host NIS. We also propose that acquisitions by high-tech ( versus non-high-tech) EMNEs need a stronger home NIS due to the technological complexity of the industry, and are limited when the complexity of a stronger host NIS adds to the industry context. We find support for most of our arguments on 179 acquisitions in the Triad by Brazilian, Russian, Indian and Chinese multinationals.
- Published
- 2017
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49. Boundary spanners and intra-MNC knowledge sharing: The roles of controlled motivation and immediate organizational context
- Author
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Grazia D. Santangelo and Dana Minbaeva
- Subjects
Knowledge management ,business.industry ,Strategy and Management ,05 social sciences ,Context (language use) ,Boundary (real estate) ,Knowledge sharing ,Intermediary ,0502 economics and business ,Organizational context ,Business ,050207 economics ,Business and International Management ,050203 business & management - Abstract
Research summary We examine the conditions under which boundary spanners positively contribute to intra-MNC knowledge sharing. Specifically, we argue that the knowledge sharing behavior of boundary spanners should not be taken for granted, as it is affected by the individual's motivation to share knowledge and contingent upon the immediate organizational context in which the individual is located. An analysis of data covering 482 individuals located in different business units of a Danish MNC confirms our arguments. Managerial summary Boundary spanners are employees who act as knowledge intermediaries between many individuals from within and outside their organisations. They are well connected internally and externally, and share knowledge across MNC units to a greater extent than non-boundary spanners. However, their contribution to knowledge sharing should not be taken for granted as it depends on their motivation and their immediate context.
- Published
- 2017
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50. Local Environmental Non-Profit Organizations and the Green Investment Strategies of Family Firms
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Daniela Maggioni and Grazia D. Santangelo
- Subjects
Economics and Econometrics ,Embeddedness ,Investment strategy ,Control (management) ,Settore SECS-P/02 - POLITICA ECONOMICA ,Settore SECS-P/06 - ECONOMIA APPLICATA ,Sample (statistics) ,010501 environmental sciences ,01 natural sciences ,ENPOs ,Family firms ,GIS ,Sectoral regulation ,0502 economics and business ,Economics ,Settore SECS-P/01 - Economia Politica ,Industrial organization ,0105 earth and related environmental sciences ,General Environmental Science ,Risk aversion ,05 social sciences ,Resource constraints ,Non profit ,Normative ,Economic system ,050203 business & management - Abstract
We add to the debate on the determinants of firms' green investment strategies (GIS) by looking at societal stakeholders and explicitly testing the role of local environmental non-profit organizations (ENPOs) in GIS engagement by family and non-family firms. We argue that ENPOs favor GIS engagement only by family firms, which, due to their resource constraints, risk aversion and local embeddedness, are more sensitive to ENPOs normative pressure. We also suggest that the role of ENPOs is especially important for family firms' GIS in those sectors with less stringent regulations, where ENPOs may act as a substitute for the coercive pressure of regulation, and promote firms' self-regulatory behaviors. We test and find support for our arguments on a sample of about 2000 Italian manufacturing firms over the period 2001–2003. Our results are robust to the control of observable omitted variables, reverse causality and to alternative model specifications.
- Published
- 2017
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