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El fútbol como deporte demanda una serie de situaciones donde la fuerza explosiva es determinante. El objetivo de la presente investigación fue determinar los efectos que se generan sobre la fuerza explosiva del tren inferior al aplicar un programa de entrenamiento basado en el método pliométrico, en jugadores de fútbol entre 17 y 18 años de la Academia Iguarán Fútbol Club, según su posicionamiento dentro del campo de juego. El estudio incluyó 32 jugadores, agrupados en grupo control (n:16) y grupo experimental (n:16), los cuales fueron asociados por posición, defensas centrales (DC n=6), defensas laterales (DL n=6), volantes (VOL n=12) y delanteros (DEL n=8). El estudio tuvo un enfoque cuantitativo, de tipo descriptivo y diseño cuasiexperimental. El tratamiento estadístico fue realizado mediante el software estadístico ® versión 4.1.0. Los resultados demuestran que, la capacidad de salto refleja diferencias entre las posiciones, para los volantes se presentaron diferencias significativas (p=0.03) sobre las variables de tiempo de vuelo, altura de salto y picos de velocidad, ubicándose muy cerca a estos valores, los delanteros. Esto puede responder a las exigencias y/o requerimientos específicos del posicionamiento de juego, principalmente, para el desarrollo de acciones donde la fuerza es un actor protagónico. El tiempo de aplicación del programa de pliometría, genera diferentes adaptaciones a nivel muscular, teniendo en cuenta que los datos obtenidos para las diferentes posiciones reflejaron que en algunas posiciones se evidencian cambios sobre variables como la altura y la velocidad, mientras que en otras se presentan cambios sobre la fuerza y potencia. Palabras clave: fútbol, evaluación, adolescencia, método de medición. Abstract, Soccer as a sport demands a series of situations where explosive strength is determinant. The objective of the present research was to determine the effects generated on the explosive strength of the lower body when applying a training program based on the plyometric method, in soccer players between 17 and 18 years old of the Academia Iguarán Fútbol Club, according to their positioning within the field of play. The study included 32 players, grouped in control group (n:16) and experimental group (n:16), which were associated by position, central defenders (DC n=6), lateral defenders (DL n=6), midfielders (VOL n=12) and forwards (DEL n=8). The study had a quantitative approach, descriptive and quasi-experimental design. The statistical treatment was performed using the statistical software ® version 4.1.0. The results show that the jumping capacity reflects differences between positions, for the flyers there were significant differences (p=0.03) on the variables of flight time, jumping height and speed peaks, with the forwards being very close to these values. This may respond to the demands and/or specific requirements of the game positioning, mainly for the development of actions where strength is a protagonist. The application time of the plyometric program generates different adaptations at a muscular level, taking into account that the data obtained for the different positions showed that in some positions changes are evidenced on variables such as height and speed, while in others there are changes on strength and power. Keywords: soccer, assessment, adolescence, measurement method.

There is a vivid debate about the border location between North and South Atlantic swordfish stocks. Climate oscillations, East Atlantic (EA) and North Atlantic Oscillation (NAO), have a major impact on the Northern Hemisphere climate and weather conditions. The initial hypothesis of present study is that if it is considering the southern frontier, each stock will be differentially affected by both climatic oscillations, which would imply the existence of a strong border. However, a similar effect on both sides of the border would result in a permeable barrier. The results suggest that the combined effects of EA and NAO affect both the North and the South Atlantic swordfish stocks in similar ways, and consequently, the location of the border may reside farther north than the current management boundary at 5ºN.

A classic issue in ecology is to understand how similar species coexist in a given area (i.e., sympatry). The situation of dolphins in the Western Mediterranean Sea may represent a special case of sympatry in that three similar species (the short-beaked common dolphin [Delphinus delphis], the striped dolphin [Stenella coeruleoalba], and the bottlenose dolphin [Tursiops truncatus) are under strong human impacts in the same area. From the viewpoint of ecology and conservation biology, it is challenging to determine how these three dolphin species live together and avoid competitive exclusion in the setting of such impacts. The Spanish Institute of Oceanography has a dataset of dolphin species opportunistic sightings. Using these data, we constructed three binary variables, comprising the sighting of one species versus the sighting of either of the other two species. We obtained three significant probability models after performing logistic regression of these binary variables on a set of spatio-temporal explanatory variables. We analysed these models from the perspective of fuzzy set theory by applying the favourability function to the probability models, fuzzy operations overlap, and entropy. The results show that common dolphins are differentially favoured in the eastern part of the study area and far away from main shipping routes. The striped dolphin was differentially favoured in the western part of the study area, above deep waters, near main shipping routes, and in summer and spring. Finally, bottlenose dolphins were differentially favoured in the mid-western part of the study area, in winter, and over shallow waters.

El presente documento revisa la situación y aporta nuevos datos para las tortugas marinas en España durante el periodo 2013-2018. Se revisa el estado de conservación para el periodo 2013-2018 en cada una de las demarcaciones marítimas españolas: Levante –Baleares y Estrecho-Alborán para el Mediterráneo, y Noratlántica, Sudatlántica y Macaronesia en aguas del océano Atlántico. Se incluyen análisis de tendencias, las presiones y amenazas que afectan a cada especie y bibliografía actualizada. Para Caretta caretta, se recopila la información de los nidos en las costas mediterráneas españolas desde 2013 hasta 2018 y los movimientos de juveniles nacidos en España, tras su liberación. This document reviews the situation and provides new data for sea turtles in Spain during the period 2013-2018. The conservation status for such period is reviewed in each of the Spanish maritime demarcations: Levante -Baleares and Estrecho-Alborán for the Mediterranean, and Noratlántica, Sudatlántica and Macaronesia in waters of the Atlantic Ocean. Analysis of trends, pressures and threats that affect each species and updated bibliography are included. For Caretta caretta, information is collected on nests on the Spanish Mediterranean coasts from 2013 to 2018 and the movements of juveniles born in Spain, after their release.

Skipjack is an important commercial species with a tropical distribution, although captures in the Mediterranean Sea have been recorded for decades. The western Mediterranean Sea, specifically the Balearic Sea, is a spawning area for several tuna species. We hypothesized that the western Mediterranean warming in the last few decades could lead to the expansion of skipjack tuna spawning areas from tropical areas to the Mediterranean Sea. We analysed 454 individuals (41.8-81 cm straight fork length) caught by sport fishing vessels in offshore trolling championships in Spanish Mediterranean waters during summer months from 2014 to 2019. Analysis of the gonadosomatic index and microscopic examination of the ovaries (n=192) showed that the skipjack is reproductively active in the western Mediterranean, particularly in the Balearic Sea. These results indicate that the skipjack has expanded its distribution and spawning area from tropical waters to the Mediterranean, probably owing to the gradual warming detected in the area in the last few decades. This new spawning activity in the area should be monitored in the near future to study the possible impact on other tuna species that share the distribution range and spawning area with skipjack tuna in the western Mediterranean., El listado (Katsuwonus pelamis) es una especie muy importante a nivel comercial. Aunque su distribución es tropical, desde hace décadas se registran capturas en el Mediterráneo. El Mediterráneo occidental, concretamente el mar Balear, es zona de puesta de varias especies de túnidos. Este trabajo planteó la hipótesis de que el calentamiento registrado en las últimas décadas en el Mediterráneo occidental podría producir la expansión de las áreas de puesta del Listado desde las zonas tropicales hasta el mar Mediterráneo. Analizamos 454 ejemplares (41,8-81 cm SFL) capturados por embarcaciones de pesca recreativa en campeonatos de curricán de altura durante los meses de verano de 2014 a 2019 en aguas del Mediterráneo español. El análisis del Índice Gonadosomático y el análisis microscópico de los ovarios (n=192) mostraron que la especie es reproductivamente activa en el Mediterráneo occidental, particularmente en el mar Balear. Estos resultados indican que el Listado ha ampliado su área de distribución y puesta desde aguas tropicales hasta el Mediterráneo, probablemente debido al calentamiento gradual detectado en la zona en las últimas décadas. Además, es de interés realizar un seguimiento de esta nueva actividad de puesta en un futuro próximo para estudiar el posible impacto sobre otras especies de túnidos con las que comparte tanto área de distribución como zona de puesta en el Mediterráneo occidental.

espanolRESUMEN Las enfermedades de insuficiencia renal actualmente se consideran como una patologia compleja que en sus inicios pue-de ser tratada de manera facil y sencilla. Sin embargo, si la enfermedad no es abordada a tiempo, puede desencadenar hacia la insuficiencia renal terminal generando complicaciones que deben ser tratadas a traves del tratamiento con dialisis y renal sustitutivo. La evolucion del paciente hacia la perdida de la funcion renal se ocasiona de manera progresiva, pro-ducto de causas asociadas con la hipertension arterial (HTA) y la diabetes mellitus. Esta afeccion, se considera comun y se encuentra con frecuencia tanto en la practica comunitaria como en los pacientes hospitalizados. Tiene gran impacto en aquellos pacientes que llegan a ser sometidos a dialisis debido a los cambios de vida a los cuales son sometidos y la aceptacion del tratamiento, lo que reduce sus expectativas de vida. No obstante, sigue siendo una enfermedad heterologa, y seguir los principios basicos facilita la investigacion donde el tratamiento inicial sigue una via estandar en la mayoria de los pacientes. Este articulo se basa en mostrar y brindar informacion acerca de las estrategias terapeuticas, incluidas aquellas en situaciones especiales, en aras de ayudar al medico a decidir cuando derivar a un nefrologo y cuando considerar la terapia de reemplazo renal. EnglishThe injuries of renal insufficiency are currently considered to be a complex pathology that can be treated in a common and common way. Without the embargo, if not affected by the time, it is possible to undermine the renal terminal insuffi-ciency generating complications that must be treated through treatment with dual and renal replacement. The evolution of patients has lost renal function by progressive manners, the product of cases associated with arterial hypertension (HTA) and diabetes mellitus. This action shall be taken into account and provided with the frequency of Community practice in hospitalized patients. There is a great deal of impact on patients who are expected to receive legal changes to life chang-es to their needs and acceptance of treatment, which reduces their expectations of life. However, a heterologous nurse should be provided and basic principles facilitated by the investigation of the initial treatment should be established in the patients' history. This article is based on the provision and provision of information on therapeutic strategies, including in special situations, in the case of medical aids, and how to derive a nephrologist and need to consider renal relapse therapy.

La Esteanosis Hepática también denominada como enfermedad del hígado graso no alcohólico (EHGNA), se caracteriza por la acumulación de grasa en el hígado que no es causada por el consumo de alcohol, donde las personas que lo padecen no tienen ni siquiera antecedentes de consumo de alcohol. De acuerdo con la aparición del nuevo Covid 19 se ha observado una relación en base a los pacientes que presentan esta patología y el riesgo de padecer el nuevo coronavirus de manera mayormente agresiva con posibles riesgos de hospitalización y ventilación. El objetivo de este estudio es investigar la ubicación, extensión y tipo de afectación de la infección por la enfermedad inducida por el nuevo coronavirus 2019 (COVID-19) y la esteatosis hepática, a través, de una revisión bibliográfica que permitió reunir temas que se relacionan con el investigado enfocados en la tomografía computarizada (TC) de tórax inicial. La relación entre el hígado graso y la gravedad de la enfermedad también se investigó de acuerdo con los valores del índice de atenuación del hígado (LAI). En tal sentido, se observa que la prevalencia de la enfermedad grave es mayor en los pacientes con esteatosis hepática que en el grupo no esteatótico. Por lo tanto, la presencia de hígado graso es un fuerte predictor para enfermedad grave.

Being a person with functional diversity can´t be an ideal for not playing sport, although their motivations will differ from those without disabilities. Adapting the different formats to the conditions of its practitioners has made wheelchair basketball today the most practiced. Different studies show that it promotes a person´s independence and covey’s great values such as overcoming, being also a great agent of social integration and rehabilitator (Moreno, 2019). In view of this premise, the purpose of this article is to know the reasons why 30 players belonging to the federations of Andalusia, Aragon, the Basque Country and Catalonia have to start in this sport, as well as the benefits that it brings to them. The study was conducted under a non-experimental and descriptive empirical research design, based on survey techniques, the questionnaire being the strategy used to gather information. The results show recreational and social motivations when deciding to practice this sport, finding benefits linked to the improvement of its physical condition, the overcoming of barriers, psychological and emotional stability, mutual support and the generation of new social relations, aspects that significantly improve your quality of life. Ser una persona con diversidad funcional no puede ser óbice para no practicar deporte, aunque sus motivaciones diferirán de aquellas que no tengan discapacidad. La adaptación de los diferentes formatos a las condiciones de sus practicantes ha hecho que el baloncesto en silla de ruedas sea hoy de los más populares. Diferentes estudios evidencian que promociona la independencia de la persona y transmite grandes valores como la superación, siendo además un gran agente de integración social y rehabilitador (Moreno, 2019). Ante esta premisa, el propósito de este artículo es conocer los motivos por lo que 30 jugadores y jugadoras pertenecientes a las federaciones de Andalucía, Aragón, País Vasco y Cataluña tienen para iniciarse en este deporte, así como los beneficios que les reporta. El estudio se realizó al amparo de un diseño de investigación empírica no experimental y descriptivo, basado en técnicas de encuesta, siendo el cuestionario la estrategia empleada para recoger información. Los resultados muestran motivaciones recreativas y sociales a la hora de decidirse por practicar este deporte, encontrando beneficios ligados a la mejora de su condición física, a la superación de barreras, a la estabilidad psicológica y emocional, al apoyo mutuo y a la generación de nuevas relaciones sociales, aspectos que mejoran de un modo significativo su calidad de vida. Ser uma pessoa com diversidade funcional não pode ser um obstáculo para não praticar esportes, embora suas motivações sejam diferentes daquelas que não possuem deficiência. A adaptação dos diferentes formatos às condições dos seus praticantes fez do basquete em cadeira de rodas um dos mais populares populares da atualidade. Diferentes estudos mostram que promove a independência da pessoa e transmite grandes valores como o auto-aperfeiçoamento, sendo também um grande agente de integração social e reabilitação (Moreno, 2019). Tendo em conta esta premissa, o objectivo deste artigo é conhecer as razões pelas quais 30 jogadores pertencentes às federações da Andaluzia, Aragão, País Basco e Catalunha têm para se iniciar neste desporto, bem como os benefícios que lhes traz. O estudo foi realizado sob um delineamento de pesquisa empírica não experimental e descritiva, baseada em técnicas de inquérito, sendo o questionário a estratégia utilizada para recolher informação. Os resultados mostram motivações recreativas e sociais quando se decide praticar este desporto, encontrando benefícios ligados à melhoria de sua condição física, superação de barreiras, estabilidade psicológica e emocional, apoio mútuo e geração de novas relações sociais, aspectos que melhoram significativamente a sua qualidade de vida .

Deep-habitat cetaceans are generally difficult to study, leading to a limited knowledge of their population. This paper assesses the differential distribution patterns of three deep-habitat cetaceans (Sperm whale—Physeter macrocephalus,Risso’s dolphin—Grampus griseus &Cuvier’s beaked whale—Ziphius cavirostris). We used data of 842 opportunistic sightings of cetaceans in the western Mediterranean sea. We inferred environmental and spatio-temporal factors that affect their distribution. Binary logistic regression models were generated to compare the presence of deep-habitat cetaceans with the presence of other cetacean species in the dataset. Then, the favourability function was applied, allowing for comparison between all the models. Sperm whale and Risso’s dolphin presence was differentially favoured by the distance to towns in the eastern part of the western Mediterranean sea. The differential distribution of sperm whale was also influenced by the stability of SST, and that of the Risso’s dolphin by lower mean salinity and higher mean Chlorophyll A concentration. When modelling the three deep-habitat cetaceans (including Cuvier’s beaked whale), the variable distance to towns had a negative influence on the presence of any of them more than it did to other cetaceans, being more favourable far from towns, so this issue should be further investigated.

The Atlantic bluefin tuna is a highly migratory species emblematic of the challenges associated with shared fisheries management. In an effort to resolve the species' stock dynamics, a genomewide search for spatially informative single nucleotide polymorphisms (SNPs) was undertaken, by way of sequencing reduced representation libraries. An allele frequency approach to SNP discovery was used, combining the data of 555 larvae and young-of-the-year (LYOY) into pools representing major geographical areas and mapping against a newly assembled genomic reference. From a set of 184,895 candidate loci, 384 were selected for validation using 167 LYOY. A highly discriminatory genotyping panel of 95 SNPs was ultimately developed by selecting loci with the most pronounced differences between western Atlantic and Mediterranean Sea LYOY. The panel was evaluated by genotyping a different set of LYOY (n = 326), and from these, 77.8% and 82.1% were correctly assigned to western Atlantic and Mediterranean Sea origins, respectively. The panel revealed temporally persistent differentiation among LYOY from the western Atlantic and Mediterranean Sea (FST = 0.008, p = .034). The composition of six mixed feeding aggregations in the Atlantic Ocean and Mediterranean Sea was characterized using genotypes from medium (n = 184) and large (n = 48) adults, applying population assignment and mixture analyses. The results provide evidence of persistent population structuring across broad geographic areas and extensive mixing in the Atlantic Ocean, particularly in the mid-Atlantic Bight and Gulf of St. Lawrence. The genomic reference and genotyping tools presented here constitute novel resources useful for future research and conservation efforts., This work was carried out under the provision of the ICCAT Atlantic-wide Research Programme for Bluefin Tuna (GBYP), funded by the European Union, by several ICCAT CPCs, the ICCAT Secretariat and other entities (see: http://www.iccat.int/GBYP/en/Budget.htm). Additional funds were provided by the MARES Joint Doctorate Programme Selected Under Erasmus Mundus and coordinated by Ghent University (FPA 2011-0016). Larvae from the Balearic Sea were provided by the ATAME project “Bluefin tuna abundance indices: towards recruitment estimators based on larval ecology” (CTM 2011-29525-C04-02) and the BLUEFIN project “Modelling bluefin spawning areas variability and population dynamics in the Western Mediterranean” (IEO-SOCIB agreement).

The Western Mediterranean Sea connects the Atlantic Ocean with the rest of the Mediterranean Sea through the Strait of Gibraltar. The Western Mediterranean Sea is important area for cetaceans and it contains highly productive feeding areas, such as the Pelagos Sanctuary and the South Balearic eddy. The main aim of this study was to assess the suitability of a group of Important Marine Mammal Areas (IMMAs) for the conservation of cetaceans inhabiting this area. There were 398 (46.44%) opportunistic sightings (OS) within a number of IMMAs and 459 (53.56%) sightings outside of IMMAs in this area. Trend surface analysis was used to select the OSs (GPOSs hereafter) most likely to be observed within IMMAs as a function of their geographical position. Significant differences were found between the observed GPOS rate and the expected GPOS rate weighted by the surface area of each IMMA. Specifically, there were more sightings than expected in the Alboran Sea IMMA than in the North West Mediterranean Sea, Slope, and Canyon System IMMA. In the latter area, there were fewer sightings than expected, Sí

One the problems with fisheries assessment and management is the presence of multiple species in a single fishery. In such cases, each species may respond differently to management measures. In this study, we report for the first time the presence of a second species, the frigate tuna, Auxis thazard (Lacepede, 1800), in the fishery for bullet tuna, Auxis rochei (Risso, 1810), off the Iberian Peninsula and the western-central Mediterranean Sea. The bullet tuna is heavily targeted by both artisanal and commercial fisheries; thus, the presence of a second species may complicate management. Seven frigate tuna individuals (1.6%; 95% CI 0.7%–3.4%) were detected after analyzing more than 400 individuals, and they were unambiguously assigned to the species bullet tuna after the analysis of two unlinked genetic loci (nuclear gene Tmo-4c4 and the mitochondrial DNA control region). The unexpected presence of a species distributed in temperate and tropical waters, such as the frigate tuna in this northern location, may be a consequence of global warming. However, continuous monitoring with a validated methodology for species identification is needed to confirm this hypothesis.

El propósito del proyecto investigativo es analizar la hiperuricemia y perfil lipídico durante el embarazo como predictor de preeclampsia entre las edades de 20 a 40 años y obtener un tratamiento oportuno. Objetivo: Analizar la asociación de uricemia y lípidos durante el embarazo como predictor de preeclampsia. La hipótesis a corroborar es el aumento de ácido úrico y del perfil lipídico correspondiente como un predictor de preeclampsia. Metodología a utilizar es una investigación de diseño documental, descriptivo de corte transversal. Obtuvimos que la hiperuricemia y el perfil lipídico puedan llegar hacer un biomarcador predictor de la preeclampsia y que los factores de riesgo pueden ser factores hipertensivos, daño renal, daño a diferentes órganos, edad, antecedentes familiares, diabetes mellitus, etc. Se concluye afirmando que los niveles de ácido úrico y lípidos pueden convertirse en un biomarcador clave para el tratamiento oportuno y eficaz de la preeclampsia precoz.

Funder: Wellcome Trust (GB), Funder: Research Trainees Coordinating Centre; doi: http://dx.doi.org/10.13039/501100000659, Funder: British Heart Foundation; doi: http://dx.doi.org/10.13039/501100000274, Funder: Karolinska Institute, Background: The vascular endothelium has important endocrine and paracrine roles, particularly in the regulation of vascular tone and immune function, and it has been implicated in the pathophysiology of a range of cardiovascular and inflammatory conditions. This study uses a series of transgenic murine models to explore for the first time the role of the hypoxia-inducible factors, HIF-1α and HIF-2α in the pulmonary and systemic circulations as potential regulators of systemic vascular function in normoxic or hypoxic conditions and in response to inflammatory stress. We developed a series of transgenic mouse models, the HIF-1α Tie2Cre, deficient in HIF1-α in the systemic and pulmonary vascular endothelium and the L1Cre, a pulmonary endothelium specific knockout of HIF-1α or HIF-2α. In vivo, arterial blood pressure and metabolic activity were monitored continuously in normal atmospheric conditions and following an acute stimulus with hypoxia (10%) or lipopolysaccharide (LPS). Ex vivo, femoral artery reactivity was assessed using wire myography. Results: Under normoxia, the HIF-1α Tie2Cre mouse had increased systolic and diastolic arterial pressure compared to litter mate controls over the day–night cycle under normal environmental conditions. VO2 and VCO2 were also increased. Femoral arteries displayed impaired endothelial relaxation in response to acetylcholine mediated by a reduction in the nitric oxide dependent portion of the response. HIF-1α L1Cre mice displayed a similar pattern of increased systemic blood pressure, metabolic rate and impaired vascular relaxation without features of pulmonary hypertension, polycythaemia or renal dysfunction under normal conditions. In response to acute hypoxia, deficiency of HIF-1α was associated with faster resolution of hypoxia-induced haemodynamic and metabolic compromise. In addition, systemic haemodynamics were less compromised by LPS treatment. Conclusions: These data show that deficiency of HIF-1α in the systemic or pulmonary endothelium is associated with increased systemic blood pressure and metabolic rate, a pattern that persists in both normoxic conditions and in response to acute stress with potential implications for our understanding of the pathophysiology of vascular dysfunction in acute and chronic disease.

The Yucatan yellow bat (Rhogeessa aeneus) is a poorly known species endemic to the Yucatan Peninsula, mainly distributed in tropical forests of the three Mexican states of Campeche, Quintana Roo, and Yucatan. Here, we report the first record of this species in Cayo Centro, the main cay of Banco Chinchorro atoll, located in southern Quintana Roo, Mexico, 47 km from the mainland in the Caribbean Sea. On May 2021, we captured three individuals of R. aeneus on Cayo Centro in a low coastal forest consisting mostly of Bursera simaruba. This is the second species of bat reported for the atoll, and more studies are needed to further the investigation on the species diversity and status of the populations there.

Pulmonary arterial hypertension (PAH) is a destructive disease of the pulmonary vasculature often leading to right heart failure and death. Current therapeutic intervention strategies only slow disease progression. The role of aberrant hypoxia-inducible factor (HIF)2α stability and function in the initiation and development of pulmonary hypertension (PH) has been an area of intense interest for nearly two decades. Here we determine the effect of a novel HIF2α inhibitor (PT2567) on PH disease initiation and progression, using two pre-clinical models of PH. Haemodynamic measurements were performed, followed by collection of heart, lung and blood for pathological, gene expression and biochemical analysis. Blood outgrowth endothelial cells from idiopathic PAH patients were used to determine the impact of HIF2α-inhibition on endothelial function. Global inhibition of HIF2a reduced pulmonary vascular haemodynamics and pulmonary vascular remodelling in both su5416/hypoxia prevention and intervention models. PT2567 intervention reduced the expression of PH-associated target genes in both lung and cardiac tissues and restored plasma nitrite concentration. Treatment of monocrotaline-exposed rodents with PT2567 reduced the impact on cardiovascular haemodynamics and promoted a survival advantage. In vitro, loss of HIF2α signalling in human pulmonary arterial endothelial cells suppresses target genes associated with inflammation, and PT2567 reduced the hyperproliferative phenotype and overactive arginase activity in blood outgrowth endothelial cells from idiopathic PAH patients. These data suggest that targeting HIF2α hetero-dimerisation with an orally bioavailable compound could offer a new therapeutic approach for PAH. Future studies are required to determine the role of HIF in the heterogeneous PAH population., PAH is a debilitating disease with no cure. There is an unmet need for new transformative therapies. Targeting HIF2α function through inhibiting ARNT hetero-dimerisation reduces many clinical symptoms associated with established PH disease in animals. https://bit.ly/3jHK8PS

Bigeye tuna (Thunnus obesus, Lowe, 1839) is one of the eight recognized species of the genus Thunnus. It is considered a tropical species distributed in the Atlantic, Pacific and Indian Oceans. To date, no validated presence of this species has been reported inside the Mediterranean Sea. This study, however, confirms, for the first time, the presence of three young individuals of this species within the Mediterranean Sea Open Access funding provided thanks to the CRUE-CSIC agreement with Wiley

Marine megafauna typically include large pelagic sharks, sea turtles, seabirds, and marine mammals. These megafauna are mainly associated with pelagic ecosystems through which they undertake long-distance migration. The Alboran Sea connects the Atlantic Ocean and Mediterranean Sea and is thus a relevant hotspot for marine megafauna. In this area, the overlap between various human activities—such as marine traffic or fisheries on the north and south coasts—and pollution entails the capture or mortality of marine megafauna. We review the main research and findings on marine megafauna in the Alboran Sea and discuss research approaches that could provide suggestions for the effective management of large marine ecosystems.

11 pages, 4 figures, 1 table, Albacore Thunnus alalunga and skipjack tuna Katsuwonus pelamis are highly migratory species that are usually caught together in the Western Mediterranean. These species are top predators that are highly affected by the biomagnification process through the trophic chain. Bioaccumulation pattern of the main metal pollutants (mercury, Hg; lead, Pb; and cadmium, Cd) were analyzed in muscle tissues of 52 individuals (26 T. alalunga and 26 K. pelamis) of these highly consumed species in order to address two objectives: (1) compare the species-specific bioaccumulation between these large-pelagic species, and (2) assess the healthy properties of such valuable resources based on the trace metal limits established by the European Commission Regulation (ECR). Both generalized linear mixed models and redundancy analysis indicated a differential bioaccumulation between these two tuna species. While T. alalunga accumulates higher concentrations of Hg (0.1996 ± 0.0602 mg·kg-1 weight wet-ww), K. pelamis accumulates higher concentrations of Cd (0.0076 ± 0.0049 mg·kg-1 ww) and Pb (0.0031 ± 0.0017 mg·kg-1 ww). Size and trophic ecology support the differences detected in the bioaccumulation pattern. Heavy metal concentrations were below the tolerable limits considered by ECR (1, 0.1, and 0.3 mg·kg-1 ww for Hg, Cd, and Pb, respectively), This work was in part funded by the IEO project GPM-1719 and by the EU through the European Maritime and Fisheries Fund (EMFF) within the National Program of collection, management, and use of data in the fisheries sector and support for scientific advice regarding the Common Fisheries Policy. Antoni Sureda was supported by Instituto de Salud Carlos III, Grant Number: CIBEROBN CB12/03/30038. Jorge Hernández-Urcera was supported by a Juan de la Cierva’s post-doc research grant (#FJCI-2016-30990) funded by the Spanish Ministry of Science, Innovation and Universities. Miguel Cabanellas-Reboredo was supported by a postdoctoral contract co-funded by the Regional Government of the Balearic Islands and the European Social Fund 2014–2020

The aim of this article is to respond, by means of a nonexperimental empirical study, to the training professional demands of primary education teachers, who understand that their professional undertaking must be fully inclusive of all student profiles. By means of a scaled assessment questionnaire, this article describes the training needs of a representative and standardized group of teachers in the Spanish city of Cordoba. Additionally, through the application of factor analysis, it channels these demands into training modules that should guide specific teaching activities in the future. The principal components extracted understand continuing professional development through five spheres of actions: the teaching of physical education, education and teaching tools, working strategies in the classroom, teaching abilities, and information communication technologies resources. These basic training lines pursue the triple goal of ensuring the professional development of teachers, promoting academic success among all students, and fostering quality teaching. Subscribe to TPE

Se presenta una experiencia práctica llevada a cabo en el CEIP Bernardo Barco (La Campana, Sevilla) con el alumnado de 6º de educación primaria, basada en el desarrollo y en la adquisición de actitudes y valores positivos que vayan encaminados al desarrollo de nuevos aprendizajes vinculados con la inteligencia emocional. Las actividades desarrolladas a lo largo de las seis semanas de implantación de la propuesta didáctica han revelado que existe un aumento de las conductas positivas y de la mejora de los valores y el trabajo en equipo, lo cual repercute positivamente en el clima de aula de esta y las demás asignaturas en las que participa el alumnado. El trabajo a través de los componentes básicos de la inteligencia emocional utilizando como eje conductor el fútbol ha permitido dotar al alumnado de herramientas de trabajo en grupo, habilidades comunicativas, herramientas para la resolución de conflictos y estrategias para la toma de decisiones.