Search

Monotherpenes play an important role attributed to the therapeutic effect of compounds of plant origin. Due to this it has increased use of the computational tools as a means to assist in the evaluation in the early stages in the planning of a new drug, analyzing in advance the in vitro and in vivo tests its pharmacological properties, bioavailability and toxicity. In this study, we aimed to evaluate the monoterpene Borneol its pharmacological, toxicological and bioavailability effect under an in silico study model. The free software PASS Online®, Admetsar and Molinspiration were used in the study for in silico activities of monotrene borneol, in order to evaluate the pharmacological, toxicological and bioavailability activities by means of predictions. The results showed that the Borneol molecule has 10 possible pharmacological activities related to Dentistry, such as antiinflammatory, antifungal, antibacterial and antiviral (herpes); presenting low risk of theoretical oral toxicity and being carcinogenic; besides respecting the five rules of lipinski, thus having good oral bioavailability. The in silico study of monoterpene Borneol demonstrated that this compound had several possible biological effects on the human body as well as good oral bioavailability and a low theoretical risk profile of presenting oral cytotoxicity. [ABSTRACT FROM AUTHOR]

Aesthetics is one of the concerns of the human being, and smile is one of its fundamental constituents. The use of composite resin restorations associated with intraradicular retainers is indicated in cases of major anterior and posterior tooth loss. The present report aims to present a rehabilitation treatment using pin prefabricated fiberglass associate the direct restoration in composite resin. A 37-year-old male patient was referred for aesthetic rehabilitation of a lower left first molar (36) after completion of endodontic treatment. For this purpose, the two conduits (mesial and distal) were planned and performed, two fiberglass pins obeying clinical protocol and coronary reconstruction of the mesial, occlusal, distal and vestibular faces in composite resin. The work emphasizes from the aesthetic importance of dentistry, passing through the support and importance of the pins of glass fiber and reconstruction of the tooth with composite resin, providing an integrated treatment and with viability for the patient who cannot opt for a prosthetic treatment. [ABSTRACT FROM AUTHOR]

Teeth that have undergone endodontic treatment and have lost part of the dental structure due to fracture usually require intraradicular retainers to promote retention to the future crown. Current aesthetic standards have occurred in recent years a rapid evolution in regard to free metal prostheses. To combine all the advantages of these biomaterials to harmoniously rehabilitate a superior premolar. Patient sought dental care and clinical examination revealed fracture in element 24 already treated endodontically. Intrarradicular fiberglass retainer was planned, in agreement with the patient, following the principle of disruption of 2/3 of the root canal for insertion of the pin with posterior rehabilitation in a fixed crown free of metal, respecting the protocol. The molding procedure was done by the technique of double impression with the aid of retractor wire # 0 with condensation silicone, light and heavy base. The models were made in special type IV gypsum and sent to the laboratory to produce the final ceramoceramic crown of the IPS E-max system. Thus, there was an improvement in the quality of life of the patient, since requirements such as satisfaction in the aesthetics of the unitary prosthesis, smile aesthetics and phonetics were applied, having a positive impact. [ABSTRACT FROM AUTHOR]

Copyright of Brazilian Journal of Surgery & Clinical Research is the property of Master Editora and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)