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133 results on '"DE LUCA, Grazia"'

8. Taurine Biosynthesis in Ox Retina

Author

Macaione, Salvatore, Di Giorgio, Rosa Maria, De Luca, Grazia, Nisticò, Giuseppe, Cavallini, Doriano, editor, Gaull, Gerald E., editor, and Zappia, Vincenzo, editor

Published
1980
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9. Morphological and Functional Alterations in Human Red Blood Cells Treated with Titanium Citrate

Author

De Luca Grazia, Gugliotta Tiziana, Romano Orazio, Romano Leonardo, Romano Pietro, Scuteri Adriana, and Rigano Caterina

Subjects
biology, Chemistry, Scanning electron microscope, Titanium citrate, chemistry.chemical_element, Glutathione, chemistry.chemical_compound, Membrane, Reaction rate constant, Biochemistry, biology.protein, Band 3, Intracellular, Nuclear chemistry, Titanium
Abstract

The morphological and functional effects of titanium (Ti) citrate on human erythrocytes were studied by scanning electron microscope (SEM), sulphate uptake via band 3 protein and by determining the reduced and oxidised glutathione (GSH and GSSG, respectively) concentrations. The rate constant for sulphate uptake was significantly lower after Ti citrate treatment. Ti citrate (0.001 and 0.0025 mM) significantly decreased erythrocyte GSH and increased GSSG concentrations. At 0.005 mM Ti citrate, the intracellular GSH could not be tested due to significant cellular damage. SEM of erythrocytes treated with 0.001 mM and 0.0025 mM Ti citrate showed structural membrane defects but almost normal cellular diameters. At even higher Ti citrate concentrations (0.005 mM), erythrocytes showed obvious morphological alteration and shape changes compromising the cells physiological functions. In conclusion, although the Ti concentrations used in our experiments are physiologically high, the cumulative effect of prolonged exposure to much lower doses of Ti, as might occur during total hip replacement, should be considered for further experimental testing.

Published
2011
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16. Full-length transglutaminase 2 and its short isoform are overexpressed in human astrocytomas

Author

Macaione, Vincenzo, Aguennouz, M'Hammed, Tomasello, C, Barbagallo, I, Conti, Alfredo, DE PASQUALE, M. G., Germanò, N, Tomasello, F, DI GIORGIO, Rosa Maria, DE LUCA, Grazia, Campisi, A, Vanella, A., MACAIONE V., AGUENNOUZ M, TOMASELLO C, BARBAGALLO I, CONTI A, DE PASQUALE M.G, GERMANÒ N, TOMASELLO F, DI GIORGIO R.M, DE LUCA G, CAMPISI A, and VANELLA A

Subjects
Transglutaminase 2, glioma, isoform, human astrocytoma
Published
2008

20. L-arginine: a new opportunity in the management of clinical derangements in dialysis patients

Author

Bellinghieri, Guido, Santoro, Domenico, Mallamace, Agostino, DI GIORGIO, Rosa Maria, DE LUCA, Grazia, and Savica, Vincenzo

Subjects
Adult, Male, medicine.medical_specialty, Endothelium, Arginine, L- Arginine, Renal disease, Dialysis, Medicine (miscellaneous), Nitric Oxide, Nitric oxide, chemistry.chemical_compound, Renal Dialysis, Internal medicine, medicine, Animals, Humans, Diabetic Nephropathies, Endothelial dysfunction, Essential amino acid, Aged, chemistry.chemical_classification, Nutrition and Dietetics, biology, business.industry, Middle Aged, medicine.disease, Nitric oxide synthase, Arginase, medicine.anatomical_structure, Endocrinology, chemistry, Nephrology, Hypertension, biology.protein, Citrulline, Kidney Failure, Chronic, Female, Endothelium, Vascular, business, Arginine decarboxylase
Abstract

L-Arginine is an essential amino acid for infants and growing children, as well as for pregnant women. This amino acid is a substrate for at least 5 enzymes identified in mammals, including arginase, arginine-glycine transaminase, kyotorphine synthase, nitric oxide synthase, and arginine decarboxylase. L-arginine is essential for the synthesis of creatine, urea, polyamines, nitric oxide, and agmatine. Arginine may be considered an essential amino acid in sepsis, and its supplementation could be beneficial in this clinical setting by improving microcirculation and protein anabolism. Rats receiving arginine-supplemented parenteral nutrition showed an increased ability to synthesize acute phase proteins when challenged with sepsis. Finally, L-arginine exerts antihypertensive and antiproliferative effects on vascular smooth muscles. It has been shown to reduce systemic blood pressure in some forms of experimental hypertension. Endothelial dysfunction and reduced nitric oxide bioactivity are associated with increased incidence of cardiovascular diseases. A beneficial effect of acute and chronic L-arginine supplementation on endothelial derived nitric oxide production and endothelial function has been shown. In end-stage renal disease patients, the rate of de novo arginine synthesis seemed to be preserved. Our preliminary data on a group of dialysis patients showed that predialysis arginine levels were stable in a normal range during the dialysis session and that hypertensive patients had lower arginine-citrulline ratio than normotensive patients.

Published
2006

44. 11-cis- Retinol dehydrogenase

Author

Nicotra, C. M. A., Paganini, A., Taibi, G., Schiavo, M. R., Gueli, M. C., and DE LUCA, Grazia

Published
1994

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