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2. De pupil belicht

Author

Groot, A L W, Maillette de Buy Wenniger, L J, de Vries-Knoppert, W A E J, Odekerken, V J J, Petzold, A, Ophthalmology, Neurology, APH - Methodology, and APH - Mental Health

Subjects
genetic structures
Abstract

Testing the pupillary response is a quick and valuable diagnostic measure for certain neurological and ophthalmological diseases in patients. The pupillary response can aid in localizing abnormalities in important parts of the visual system and brainstem, provided that the tests are executed and interpreted correctly. When an abnormal pupillary response is found, it is important to differentiate between an afferent problem (eyeball, retina, optical nerve), brain stem pathology, or an efferent problem (parasympathetic fibers of the oculomotor nerve, iris sphincter muscle). We describe the technique of the ophthalmological examination, the normal neurophysiology and the possible abnormal pupil responses in patients with intact and decreased consciousness.

Published
2020

5. Strategy for the management of uncomplicated retinal detachments: the European vitreo-retinal society retinal detachment study report 1

Author

BENMERZOUGA N, METTI F, RAZZARI A, MIESBAUER P, SCHÖNHERR U, ZEYNALOVA Z, BASHIR SJ, JACOB J, KOCH P, LADHA R, SMETS E, STALMANS P, DARE A, DEVENYI R, LAM WC, SHAHEEDA M, POTAMITIS T, CHRISTENSEN SR, RAYES E, MORTADA H, SHOUMAN A, HOLM M, ALBINET P, AMAR JP, BECQUET F, BERROD JP, BOULZE M, BOSCHER C, COURJARET JC, DENION E, FOURMAUX, E, GUIGOU S, HAMON F, LAFONTAINE PO, LE ROUIC JF, LEYNAUD JL, NOCHEZ Y, PERONE JM, RYSANEK B, SOYEUR R, BOPP S, BRIX A, HÖHN F, KUSSEROW C, LUCKE K, MOHR A, SCHÜLER A, WEINBERGER A, GOTZARIDIS S, KARATZENIS D, STEFANIOTOU M, K. TSILIMBARIS MK, TSOURIS D, TSANG CW, GABOR R, SZIJARTO Z, BABU N, BANKER AS, BAPAYE M, KELKAR A, ENTEZARI, M, FATEH MOGHADAM HF, RAMEZANI A, SAFARPOUR LIMA B, OMER K, BOSCIA F, CHIARA FRENO M, CIAN R, DONVITO G, FACINO M, LESNONI G, LIUZZI, F, METE M, MININNI F, MOCHI B, PRIMAVERA V, PERTILE G, TURCO I, VASTARELLA P, FONG K, LEE M, VP LOO A, ARAGON HARRISON O, FLORES AGUILAR M, LOPEZ MONTERO LM, LOPEZCARASA HERNANDEZ G, VELASCO I, BOEYDEN V, BOSSCHA M, DE VRIES KNOPPERT W, LINDSTEDT, E. RENARDEL DE LAVALETTE VW, VAN DEN BIESEN PR, ALHASSAN M, BAERLAND TP, BOBER AM, FORSAA V, FOSSEN K, VARHAUG P, ATIENZA J.r. NF, CISIECKI S, FRYCZKOWSKI P, KOWAL LANGE A, MICHALEWSKA Z, MICHALEWSKI J, NAWROCKI J, NOWOSIELSKA A, ODROBINA D, PIETRAS TRZPIEL M, ZAKRZEWSKA A, MEIRELES A, TEIXEIRA S, ELSHAFEI M, DANIELESCU C, TALU S, ALTYNBAEV U, GORIN A, SEREJINE I, EL DEEB M, DAVIDOVIC S, IGNJATOVIC Z, STEFANICKOVA J, VENTER L, CHANG W, JO YL, KIM JY, LEE J, LIM ST, SAGONG M, ASCASO FJ, CASTRO J, CORDOVES L. DESCO ESTEBAN C, MORENO MANRESA J, VILAPLANA D, JANIEC S, TOMIC Z, BEN YAHIA S, ACAR N, GÜNGEL H, KAPRAN Z, OSMANBASOGLU O, OZDEK S, TOPBAS S, TOTAN Y, ÜNVER YB, CHICHUR D, DOBROVOLSKEY O, KOZLOVSKA I, LYTVYNCHUK L, PHYLYPCHUK O, POSTOLOVSKA A, SERGIIENKO A, SHEVCHYK V, WINDER S, CULOTTA J, KIM S, KING J, KURUP SK, LIN SJ, PACURARIU R, ROTH D, SINCLAIR S, WEBER P, DOAN H, TUNG T., ROMANO, MARIO, Benmerzouga, N, Metti, F, Razzari, A, Miesbauer, P, Schönherr, U, Zeynalova, Z, Bashir, Sj, Jacob, J, Koch, P, Ladha, R, Smets, E, Stalmans, P, Dare, A, Devenyi, R, Lam, Wc, Shaheeda, M, Potamitis, T, Christensen, Sr, Rayes, E, Mortada, H, Shouman, A, Holm, M, Albinet, P, Amar, Jp, Becquet, F, Berrod, Jp, Boulze, M, Boscher, C, Courjaret, Jc, Denion, E, Fourmaux, E, Guigou, S, Hamon, F, Lafontaine, Po, LE ROUIC, Jf, Leynaud, Jl, Nochez, Y, Perone, Jm, Rysanek, B, Soyeur, R, Bopp, S, Brix, A, Höhn, F, Kusserow, C, Lucke, K, Mohr, A, Schüler, A, Weinberger, A, Gotzaridis, S, Karatzenis, D, Stefaniotou, M, K., TSILIMBARIS MK, Tsouris, D, Tsang, Cw, Gabor, R, Szijarto, Z, Babu, N, Banker, A, Bapaye, M, Kelkar, A, Entezari, M, FATEH MOGHADAM, Hf, Ramezani, A, SAFARPOUR LIMA, B, Omer, K, Boscia, F, CHIARA FRENO, M, Cian, R, Donvito, G, Facino, M, Lesnoni, G, Liuzzi, F, Mete, M, Mininni, F, Mochi, B, Primavera, V, Romano, Mario, Pertile, G, Turco, I, Vastarella, P, Fong, K, Lee, M, VP LOO, A, ARAGON HARRISON, O, FLORES AGUILAR, M, LOPEZ MONTERO, Lm, LOPEZCARASA HERNANDEZ, G, Velasco, I, Boeyden, V, Bosscha, M, DE VRIES KNOPPERT, W, Lindstedt, E., RENARDEL DE LAVALETTE VW, VAN DEN BIESEN, Pr, Alhassan, M, Baerland, Tp, Bober, Am, Forsaa, V, Fossen, K, Varhaug, P, ATIENZA J. r., Nf, Cisiecki, S, Fryczkowski, P, KOWAL LANGE, A, Michalewska, Z, Michalewski, J, Nawrocki, J, Nowosielska, A, Odrobina, D, PIETRAS TRZPIEL, M, Zakrzewska, A, Meireles, A, Teixeira, S, Elshafei, M, Danielescu, C, Talu, S, Altynbaev, U, Gorin, A, Serejine, I, EL DEEB, M, Davidovic, S, Ignjatovic, Z, Stefanickova, J, Venter, L, Chang, W, Jo, Yl, Kim, Jy, Lee, J, Lim, St, Sagong, M, Ascaso, Fj, Castro, J, CORDOVES L., DESCO ESTEBAN C, MORENO MANRESA, J, Vilaplana, D, Janiec, S, Tomic, Z, BEN YAHIA, S, Acar, N, Güngel, H, Kapran, Z, Osmanbasoglu, O, Ozdek, S, Topbas, S, Totan, Y, Ünver, Yb, Chichur, D, Dobrovolskey, O, Kozlovska, I, Lytvynchuk, L, Phylypchuk, O, Postolovska, A, Sergiienko, A, Shevchyk, V, Winder, S, Culotta, J, Kim, S, King, J, Kurup, Sk, Lin, Sj, Pacurariu, R, Roth, D, Sinclair, S, Weber, P, Doan, H, and Tung, T.

Abstract

OBJECTIVE: To study success and failure in the treatment of uncomplicated rhegmatogenous retinal detachments (RRDs). DESIGN: Nonrandomized, multicenter retrospective study. PARTICIPANTS: One hundred seventy-six surgeons from 48 countries spanning 5 continents provided information on the primary procedures for 7678 cases of RRDs including 4179 patients with uncomplicated RRDs. METHODS: Reported data included specific clinical findings, the method of repair, and the outcome after intervention. MAIN OUTCOME MEASURES: Final failure of retinal detachment repair (level 1 failure rate), remaining silicone oil at the study's conclusion (level 2 failure rate), and need for additional procedures to repair the detachment (level 3 failure rate). RESULTS: Four thousand one hundred seventy-nine uncomplicated cases of RRD were included. Combining phakic, pseudophakic, and aphakic groups, those treated with scleral buckle alone (n = 1341) had a significantly lower final failure rate than those treated with vitrectomy, with or without a supplemental buckle (n = 2723; P = 0.04). In phakic patients, final failure rate was lower in the scleral buckle group compared with those who had vitrectomy, with or without a supplemental buckle (P = 0.028). In pseudophakic patients, the failure rate of the initial procedure was lower in the vitrectomy group compared with the scleral buckle group (P = 3×10(-8)). There was no statistically significant difference in failure rate between segmental (n = 721) and encircling (n = 351) buckles (P = 0.5). Those who underwent vitrectomy with a supplemental scleral buckle (n = 488) had an increased failure rate compared with those who underwent vitrectomy alone (n = 2235; P = 0.048). Pneumatic retinopexy was found to be comparable with scleral buckle when a retinal hole was present (P = 0.65), but not in cases with a flap tear (P = 0.034). CONCLUSIONS: In the treatment of uncomplicated phakic retinal detachments, repair using scleral buckle may be a good option. There was no significant difference between segmental versus 360-degree buckle. For pseudophakic uncomplicated retinal detachments, the surgeon should balance the risks and benefits of vitrectomy versus scleral buckle and keep in mind that the single-surgery reattachment rate may be higher with vitrectomy. However, if a vitrectomy is to be performed, these data suggest that a supplemental buckle is not helpful.

Published
2013

6. Strategy for the management of complex retinal detachments: the European vitreo-retinal society retinal detachment study report 2

Author

BENMERZOUGA N, METTI F, RAZZARI A, MIESBAUER P, SCHÖNHERR U, ZEYNALOVA Z, BASHIR SJ, JACOB J, KOCH P, LADHA R, SMETS E, STALMANS P, DARE A, DEVENYI R, LAM WC, SHAHEEDA M, POTAMITIS T, CHRISTENSEN SR, RAYES E, MORTADA H, SHOUMAN A, HOLM M, ALBINET P, AMAR JP, BECQUET F, BERROD JP, BOULZE M, BOSCHER C, COURJARET JC, DENION E, FOURMAUX, E, GUIGOU S, HAMON F, LAFONTAINE PO, LE ROUIC JF, LEYNAUD JL, NOCHEZ Y, PERONE JM, RYSANEK B, SOYEUR R, BOPP S, BRIX A, HÖHN F, KUSSEROW C, LUCKE K, MOHR A, SCHÜLER A, WEINBERGER A, GOTZARIDIS S, KARATZENIS D, STEFANIOTOU M, K. TSILIMBARIS MK, TSOURIS D, TSANG CW, GABOR R, SZIJARTO Z, BABU N, BANKER AS, BAPAYE M, KELKAR A, ENTEZARI, M, FATEH MOGHADAM HF, RAMEZANI A, SAFARPOUR LIMA B, OMER K, BOSCIA F, CHIARA FRENO M, CIAN R, DONVITO G, FACINO M, LESNONI G, LIUZZI, F, METE M, MININNI F, MOCHI B, PRIMAVERA V, PERTILE G, TURCO I, VASTARELLA P, FONG K, LEE M, VP LOO A, ARAGON HARRISON O, FLORES AGUILAR M, LOPEZ MONTERO LM, LOPEZCARASA HERNANDEZ G, VELASCO I, BOEYDEN V, BOSSCHA M, DE VRIES KNOPPERT W, LINDSTEDT, E. RENARDEL DE LAVALETTE VW, VAN DEN BIESEN PR, ALHASSAN M, BAERLAND TP, BOBER AM, FORSAA V, FOSSEN K, VARHAUG P, ATIENZA J.r. NF, CISIECKI S, FRYCZKOWSKI P, KOWAL LANGE A, MICHALEWSKA Z, MICHALEWSKI J, NAWROCKI J, NOWOSIELSKA A, ODROBINA D, PIETRAS TRZPIEL M, ZAKRZEWSKA A, MEIRELES A, TEIXEIRA S, ELSHAFEI M, DANIELESCU C, TALU S, ALTYNBAEV U, GORIN A, SEREJINE I, EL DEEB M, DAVIDOVIC S, IGNJATOVIC Z, STEFANICKOVA J, VENTER L, CHANG W, JO YL, KIM JY, LEE J, LIM ST, SAGONG M, ASCASO FJ, CASTRO J, CORDOVES L. DESCO ESTEBAN C, MORENO MANRESA J, VILAPLANA D, JANIEC S, TOMIC Z, BEN YAHIA S, ACAR N, GÜNGEL H, KAPRAN Z, OSMANBASOGLU O, OZDEK S, TOPBAS S, TOTAN Y, ÜNVER YB, CHICHUR D, DOBROVOLSKEY O, KOZLOVSKA I, LYTVYNCHUK L, PHYLYPCHUK O, POSTOLOVSKA A, SERGIIENKO A, SHEVCHYK V, WINDER S, CULOTTA J, KIM S, KING J, KURUP SK, LIN SJ, PACURARIU R, ROTH D, SINCLAIR S, WEBER P, DOAN H, TUNG T., ROMANO, MARIO, Benmerzouga, N, Metti, F, Razzari, A, Miesbauer, P, Schönherr, U, Zeynalova, Z, Bashir, Sj, Jacob, J, Koch, P, Ladha, R, Smets, E, Stalmans, P, Dare, A, Devenyi, R, Lam, Wc, Shaheeda, M, Potamitis, T, Christensen, Sr, Rayes, E, Mortada, H, Shouman, A, Holm, M, Albinet, P, Amar, Jp, Becquet, F, Berrod, Jp, Boulze, M, Boscher, C, Courjaret, Jc, Denion, E, Fourmaux, E, Guigou, S, Hamon, F, Lafontaine, Po, LE ROUIC, Jf, Leynaud, Jl, Nochez, Y, Perone, Jm, Rysanek, B, Soyeur, R, Bopp, S, Brix, A, Höhn, F, Kusserow, C, Lucke, K, Mohr, A, Schüler, A, Weinberger, A, Gotzaridis, S, Karatzenis, D, Stefaniotou, M, K., TSILIMBARIS MK, Tsouris, D, Tsang, Cw, Gabor, R, Szijarto, Z, Babu, N, Banker, A, Bapaye, M, Kelkar, A, Entezari, M, FATEH MOGHADAM, Hf, Ramezani, A, SAFARPOUR LIMA, B, Omer, K, Boscia, F, CHIARA FRENO, M, Cian, R, Donvito, G, Facino, M, Lesnoni, G, Liuzzi, F, Mete, M, Mininni, F, Mochi, B, Primavera, V, Romano, Mario, Pertile, G, Turco, I, Vastarella, P, Fong, K, Lee, M, VP LOO, A, ARAGON HARRISON, O, FLORES AGUILAR, M, LOPEZ MONTERO, Lm, LOPEZCARASA HERNANDEZ, G, Velasco, I, Boeyden, V, Bosscha, M, DE VRIES KNOPPERT, W, Lindstedt, E., RENARDEL DE LAVALETTE VW, VAN DEN BIESEN, Pr, Alhassan, M, Baerland, Tp, Bober, Am, Forsaa, V, Fossen, K, Varhaug, P, ATIENZA J. r., Nf, Cisiecki, S, Fryczkowski, P, KOWAL LANGE, A, Michalewska, Z, Michalewski, J, Nawrocki, J, Nowosielska, A, Odrobina, D, PIETRAS TRZPIEL, M, Zakrzewska, A, Meireles, A, Teixeira, S, Elshafei, M, Danielescu, C, Talu, S, Altynbaev, U, Gorin, A, Serejine, I, EL DEEB, M, Davidovic, S, Ignjatovic, Z, Stefanickova, J, Venter, L, Chang, W, Jo, Yl, Kim, Jy, Lee, J, Lim, St, Sagong, M, Ascaso, Fj, Castro, J, CORDOVES L., DESCO ESTEBAN C, MORENO MANRESA, J, Vilaplana, D, Janiec, S, Tomic, Z, BEN YAHIA, S, Acar, N, Güngel, H, Kapran, Z, Osmanbasoglu, O, Ozdek, S, Topbas, S, Totan, Y, Ünver, Yb, Chichur, D, Dobrovolskey, O, Kozlovska, I, Lytvynchuk, L, Phylypchuk, O, Postolovska, A, Sergiienko, A, Shevchyk, V, Winder, S, Culotta, J, Kim, S, King, J, Kurup, Sk, Lin, Sj, Pacurariu, R, Roth, D, Sinclair, S, Weber, P, Doan, H, and Tung, T.

Abstract

OBJECTIVE: To study the outcome of the treatment of complex rhegmatogenous retinal detachments (RRDs). DESIGN: Nonrandomized, multicenter, retrospective study. PARTICIPANTS: One hundred seventy-six surgeons from 48 countries spanning 5 continents reported primary procedures for 7678 RRDs. METHODS: Reported data included clinical manifestations, the method of repair, and the outcome. MAIN OUTCOME MEASURES: Failure of retinal detachment repair (level 1 failure rate), remaining silicone oil at the study's conclusion (level 2 failure rate), and need for additional procedures to repair the detachments (level 3 failure rate). RESULTS: The main categories of complex retinal detachments evaluated in this investigation were: (1) grade B proliferative vitreoretinopathy (PVR; n = 917), (2) grade C-1 PVR (n = 637), (3) choroidal detachment or significant hypotony (n = 578), (4) large or giant retinal tears (n = 1167), and (5) macular holes (n = 153). In grade B PVR, the level 1 failure rate was higher when treated with a scleral buckle alone versus vitrectomy (P = 0.0017). In grade C-1 PVR, there was no statistically significant difference in the level 1 failure rate between those treated with vitrectomy, with or without scleral buckle, and those treated with scleral buckle alone (P = 0.7). Vitrectomy with a supplemental buckle had an increased failure rate compared with those who did not receive a buckle (P = 0.007). There was no statistically significant difference in level 1 failure rate between tamponade with gas versus silicone oil in patients with grade B or C-1 PVR. Cases with choroidal detachment or hypotony treated with vitrectomy had a significantly lower failure rate versus treatment with scleral buckle alone (P = 0.0015). Large or giant retinal tears treated with vitrectomy also had a significantly lower failure rate versus treatment with scleral buckle (P = 7×10(-8)). CONCLUSIONS: In patients with retinal detachment, when choroidal detachment, hypotony, a large tear, or a giant tear is present, vitrectomy is the procedure of choice. In retinal detachments with PVR, tamponade with either gas or silicone oil can be considered. If a vitrectomy is to be performed, these data suggest that a supplemental buckle may not be helpful. FINANCIAL DISCLOSURE(S): The author(s) have no proprietary or commercial interest in any materials discussed in this article.

Published
2013

15. [Clinical aspects of the abnormal pupillary response; shedding light on pupillary response].

Author

Groot ALW, Groot AED, Maillette de Buy Wenniger LJ, de Vries-Knoppert WAEJ, Odekerken VJJ, and Petzold A

Subjects
Diagnosis, Differential, Humans, Diagnostic Techniques, Ophthalmological, Eye Diseases diagnosis, Eye Diseases physiopathology, Pupil physiology, Reflex, Pupillary physiology, Visual Pathways physiology, Visual Pathways physiopathology
Abstract

Testing the pupillary response is a quick and valuable diagnostic measure for certain neurological and ophthalmological diseases in patients. The pupillary response can aid in localizing abnormalities in important parts of the visual system and brainstem, provided that the tests are executed and interpreted correctly. When an abnormal pupillary response is found, it is important to differentiate between an afferent problem (eyeball, retina, optical nerve), brain stem pathology, or an efferent problem (parasympathetic fibers of the oculomotor nerve, iris sphincter muscle). We describe the technique of the ophthalmological examination, the normal neurophysiology and the possible abnormal pupil responses in patients with intact and decreased consciousness.

Published
2020

16. Progression of Anterograde Trans-Synaptic Degeneration in the Human Retina Is Modulated by Axonal Convergence and Divergence.

Author

Panneman EL, Coric D, Tran LMD, de Vries-Knoppert WAEJ, and Petzold A

Abstract

In the visual pathway of patients with multiple sclerosis (MS), the inner nuclear layer (INL) of the retina is a tight barrier for retrograde trans-synaptic degeneration. In this observational, retrospective cross-sectional study, segmented macular spectral domain optical coherence tomography (OCT) volume scans were reviewed to investigate if this observation also holds true for anterograde trans-synaptic degeneration. Significant thinning was found in all retinal layers in patients with outer retinal diseases compared with the healthy controls, while there was no significant attenuation of the outer retina in patients with MS. In contrast to the tight barrier function observed with retrograde trans-synaptic degeneration, the INL appears to be more permissive for the propagation of anterograde trans-synaptic degeneration. We speculate that this may be due to the size of the area affected and be explained by convergence and divergence of axons within the retinal layers. These findings are likely relevant to future restorative stem cell treatment of the outer retinal layers, as time may matter., (© 2019 Taylor & Francis Group, LLC.)

Published
2019
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17. Time is vision in recurrent optic neuritis.

Author

Osinga E, van Oosten B, de Vries-Knoppert W, and Petzold A

Subjects
Adult, Disease Progression, Female, Humans, Male, Middle Aged, Optic Neuritis pathology, Organ Size, Recurrence, Retina pathology, Retrospective Studies, Time-to-Treatment, Tomography, Optical Coherence, Treatment Outcome, Visual Acuity, Young Adult, Adrenal Cortex Hormones therapeutic use, Neuroprotective Agents therapeutic use, Optic Neuritis diagnostic imaging, Optic Neuritis drug therapy, Retina diagnostic imaging, Retina drug effects
Abstract

In optic neuritis (ON) inflammation precedes onset of demyelination and axonal loss. The anti-inflammatory properties of corticosteroids may be most effective in the early inflammatory phase, but rapid patient recruitment remains a logistic challenge. The aim of the study was to review the effect of time to initiation of treatment on visual outcome in recurrent ON. A retrospective case note review of patients known to our centre with recurrent ON. The primary clinical outcome was change of best corrected high contrast visual acuity (BCVA). The secondary outcome was the change of optical coherence tomography (OCT) thickness of the peripapillary retinal nerve fibre layer (pRNFL) and macular ganglion cell layer (mGCL) from baseline and after a minimum of 3months following the episode of recurrent ON. Of 269 patients with a previous episode of ON, 54 experienced recurrent ON. In total 40 OCT documented episodes of relapsing ON were captured in 19 patients. Treatment within <2days led to better recovery of the BCVA (+0.02) and mGCL (-2.4µm) if compared to delayed treatment (BCVA -0.2, p=0.036, mGCL -25.6µm, p=0.019) or no corticosteroids treatment (BCVA -0.2, p=0.045, GCL -5.0µm, p=0.836). These data suggest a beneficial effect of hyperacute corticosteroid treatment. A pragmatic approach for a prospective treatment trial should consider patients with recurrent ON for logistic reasons., (Copyright © 2017 Elsevier B.V. All rights reserved.)

Published
2017
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18. Management of retinal detachments in pseudophakic patients with Artisan lenses.

Author

van der Meulen I, Gunning F, Henry Y, de Vries-Knoppert W, Gortzak-Moorstein N, and de Smet MD

Subjects
Adult, Aged, Aged, 80 and over, Case-Control Studies, Child, Female, Humans, Hyaluronic Acid therapeutic use, Lens Implantation, Intraocular, Male, Middle Aged, Retinal Detachment etiology, Retinal Perforations etiology, Retinal Perforations surgery, Retrospective Studies, Visual Acuity, Cryosurgery methods, Lenses, Intraocular, Pseudophakia complications, Retinal Detachment surgery, Scleral Buckling methods, Vitrectomy methods
Abstract

Purpose: To report the management and outcomes of retinal detachment repair in patients with Artisan intraocular lenses (IOLs) used for pseudophakic correction., Setting: Two university-based referral centers.In this retrospective case-control study, all cases of retinal detachments in patients with an Artisan IOL used for pseudophakic correction were reviewed over 5 years at 2 university clinics., Results: Of the 20 patients identified, all had a detachment in 2 or more quadrants. A retinal tear was identified in 19 patients preoperatively. Thirteen patients had a standard buckling procedure, 3 with the addition of gas; 3 required a pars plana vitrectomy; and 2 were treated with pneumatic retinopexy alone. Reattachment was achieved with 1 procedure in 11 patients, with 2 procedures in 5 patients, and with 3 procedures in 3 patients; reattachment could not be achieved in 2 cases. Anterior displacement of the lens was noted when gas tamponade was used. When the displacement was significant, sodium hyaluronate 1% (Healon was used to prevent corneal endothelial touch., Conclusions: In most cases, the Artisan lens did not significantly limit peripheral retinal visibility. Standard buckling procedures were generally successful. Given the limited support provided by the iris, the presence of gas in the vitreous cavity can lead to anterior displacement of the lens. Corneal endothelial touch can be prevented by the use of Healon, which is sufficient if short-term gas tamponade is used.

Published
2002
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19. Vitreous findings in a patient with Terson's syndrome.

Author

de Vries-Knoppert W

Subjects
Accidents, Traffic, Adult, Basement Membrane pathology, Brain Concussion complications, Brain Concussion etiology, Eye Diseases pathology, Fundus Oculi, Humans, Intracranial Pressure, Male, Syndrome, Vitrectomy, Vitreous Hemorrhage pathology, Vitreous Hemorrhage surgery, Vitreous Body pathology, Vitreous Hemorrhage etiology
Abstract

In Terson's syndrome a sudden increase in intracranial pressure due to spontaneous subarachnoid hemorrhage or head trauma may result in intraocular hemorrhage. A patient with bilateral vitreous hemorrhages underwent vitrectomy in both eyes with excellent result. In the right eye a glistening membrane was found with blood underneath, covering the macula. This was probably the internal limiting membrane (ILM). At the vitreous base and in the equatorial zone, attachment plaques are present between the ILM and the Müller cells. Because attachment plaques are missing in the posterior zone, where the ILM is much thicker, a retinal hemorrhage is capable of detaching the ILM from the retina in that area. The presence of attachment plaques is considered in relation to centripetal vitreous traction, which is absent in the area of the posterior precortical vitreous pocket (PPVP). The posterior wall of the PPVP coincides therefore probably exactly with the thick part of the ILM in the posterior zone.

Published
1995
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20. Chemoattractant and neutrophil degranulation activities related to interleukin-8 in vitreous fluid in uveitis and vitreoretinal disorders.

Author

de Boer JH, Hack CE, Verhoeven AJ, Baarsma GS, de Jong PT, Rademakers AJ, de Vries-Knoppert WA, Rothova A, and Kijlstra A

Subjects
Cells, Cultured, Enzyme-Linked Immunosorbent Assay, Eye Diseases enzymology, Eye Diseases immunology, Humans, Neutrophils immunology, Pancreatic Elastase metabolism, Retinal Diseases enzymology, Uveitis enzymology, Vitreous Body enzymology, Cell Degranulation immunology, Chemotaxis, Leukocyte immunology, Interleukin-8 immunology, Retinal Diseases immunology, Uveitis immunology, Vitreous Body immunology
Abstract

Purpose: To investigate whether the cytokine interleukin-8 (IL-8), a strong chemoattractant and activator for neutrophils, is responsible for neutrophil infiltration and degranulation in the eye in uveitis., Methods: IL-8 and elastase were measured with specific enzyme-linked immunoassays in vitreous fluid samples obtained from 69 patients with various uveitis entities. Vitreous fluid of nonuveitis patients and eye bank eyes served as controls. The chemotactic activity of vitreous fluid was tested with the Boyden chamber technique., Results: IL-8 was detected in 45% of the vitreous fluid samples from uveitis patients and in 26% of vitreous fluid samples from nonuveitis patients. Vitreous fluid samples with IL-8 levels exceeding 100 pg/ml were chemotactic for neutrophils. This chemotactic activity could be blocked by 41% to 79% with a monoclonal anti-IL-8 antibody. Elastase levels in vitreous fluid of uveitis patients with detectable IL-8 were significantly higher than those in vitreous fluid samples with no detectable IL-8., Conclusion: These results indicate that IL-8 participates in the inflammatory processes in the eye by attracting and degranulating neutrophils. It is suggested that these processes contribute to the pathogenesis of tissue destruction in uveitis.

Published
1993

21. Malignant optic glioma in adults. Case report.

Author

Taphoorn MJ, de Vries-Knoppert WA, Ponssen H, and Wolbers JG

Subjects
Combined Modality Therapy, Female, Glioma complications, Glioma surgery, Humans, Middle Aged, Nervous System Neoplasms complications, Nervous System Neoplasms surgery, Optic Nerve Diseases complications, Optic Nerve Diseases surgery, Vision Disorders etiology, Glioma pathology, Nervous System Neoplasms pathology, Optic Nerve Diseases pathology
Abstract

Malignant optic glioma in adulthood is a rare tumor that causes early loss of vision and nearly always leads to death within a year. A case history is presented illustrating the clinical and neuroradiological characteristics of the malignant optic glioma in adults. A review of the literature is given.

Published
1989
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22. Dacryocystography after paranasal sinus surgery.

Author

Hunink MG, de Vries-Knoppert WA, Balm AJ, and Luth WJ

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Humans, Lacrimal Duct Obstruction etiology, Middle Aged, Paranasal Sinus Neoplasms radiotherapy, Radiography, Retrospective Studies, Lacrimal Apparatus diagnostic imaging, Nasolacrimal Duct diagnostic imaging, Paranasal Sinuses surgery, Postoperative Complications etiology
Abstract

The influence of nasolacrimal duct dissection and irradiation of the lacrimal system on lacrimal drainage were assessed. Findings at dacryocystography, in correlation with the results of dye tests and symptoms, are presented. Lacrimal drainage obstruction was demonstrated in one of 10 patients after paranasal sinus surgery not followed by irradiation and in four of 10 patients in which surgery was followed by irradiation.

Published
1988
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