1. Voltammetric amplified platform based on ionic liquid/NiO nanocomposite for determination of benserazide and levodopa.
- Author
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Miraki, Mansoureh, Karimi-Maleh, Hassan, Taher, Mohammad A., Cheraghi, Somaye, Karimi, Fatemeh, Agarwal, Shilpi, and Gupta, Vinod Kumar
- Subjects
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IONIC liquids , *NICKEL oxide , *NANOCOMPOSITE materials , *DOPA , *DECARBOXYLASE inhibitors , *CARBON electrodes - Abstract
Abstract As an electrochemical strategy, we report application of new modified carbon paste electrode amplified with NiO nanoparticle and n -methyl-3-butylimidazolium bromide (CPE/nMBZBr/NiO-NPs) for square wave analysis of benserazide (BZ). The oxidation current of BZ improved ~3.0 times and over-potential of this drug reduces ~50 mV at CPE/nMBZBr/NiO-NPs compare to CPE. Using square wave voltammetric method, we found a relationship between concentration of BZ and oxidation current in the range 20.0 nM–400 μM. The detection limit was calculated ~8.0 nM. In the final step, the CPE/nMBZBr/NiO-NPs resolve overlapping signals BZ and levodopa for simultaneous analysis of these drugs. Graphical abstract In this study, we fabricated a highly sensitive electrochemical sensor amplified with room temperature ionic liquid and NiO nanoparticle for analysis of benserazide in the presence of levodopa. Unlabelled Image Highlights • Simultaneous determination of benserazide and levodopa in drug samples • Fabrication of novel sensor amplified with NiO nanoparticle and n -methyl-3-butylimidazolium bromide • Determination of benserazide in nanomolar level [ABSTRACT FROM AUTHOR]
- Published
- 2019
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