Search

Your search keyword '"DI PASQUALE, F"' showing total 315 results
Start Over Author "DI PASQUALE, F"
315 results on '"DI PASQUALE, F"'

6. A Powerful Tool Based on Finite Element Method for Designing Photonic Crystal Devices

Author

Cerqueira, A., Jr., Nobrega, K. Z., Di Pasquale, F., Hernandez-Figueroa, H. E., Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, de Souza, José Neuman, editor, Dini, Petre, editor, and Lorenz, Pascal, editor

Published
2004
Full Text
View/download PDF

8. Integration of Diagnostic Fiber Bragg Grating Sensors in Advanced Carbon Composite Materials

Author

Tozzetti, L., Gabardi, M., Faralli, S., Massimiliano SOLAZZI, Rajbhandari, S., Benedetti, D., Buttaro, G., and Di Pasquale, F.

Abstract

FBG sensors written by femtosecond laser pulses are embedded in carbon composite structures. A comparative analysis, supported by theory, points out the embedding process repeatability and the sensing technology effectiveness for structural health monitoring.

Published
2022
Full Text
View/download PDF

9. High-speed FBG interrogator based on FPGA-controlled fiber interferometer

Author

Elaskar Plazas, J., Ayaz, R. M. A., Tozzetti, L., Luda, M., Di Pasquale, F., and Oton, C. J.

Abstract

We report FBG interrogation measurements up to 1MS/s using a polarization-maintaining-fiber-based Sagnac interferometer monitored in real time with an FPGA system. The system has lower noise levels than commercial interrogators.

Published
2022
Full Text
View/download PDF

15. Multicenter Evaluation of Independent High-Throughput and RT-qPCR Technologies for the Development of Analytical Workflows for Circulating miRNA Analysis.

Author

Babayan, A, Neumann, MHD, Herdean, A, Shaffer, JM, Janning, M, Kobus, F, Loges, S, Di Pasquale, F, Kubista, M, Schlumpberger, M, Lampignano, R, Krahn, T, Schlange, T, Sprenger-Haussels, M, Pantel, K, Kloten, V, Babayan, A, Neumann, MHD, Herdean, A, Shaffer, JM, Janning, M, Kobus, F, Loges, S, Di Pasquale, F, Kubista, M, Schlumpberger, M, Lampignano, R, Krahn, T, Schlange, T, Sprenger-Haussels, M, Pantel, K, and Kloten, V

Abstract

BACKGROUND:Among emerging circulating biomarkers, miRNA has the potential to detect lung cancer and follow the course of the disease. However, miRNA analysis deserves further standardization before implementation into clinical trials or practice. Here, we performed international ring experiments to explore (pre)-analytical factors relevant to the outcome of miRNA blood tests in the context of the EU network CANCER-ID. METHODS:Cell-free (cfmiRNA) and extracellular vesicle-derived miRNA (EVmiRNA) were extracted using the miRNeasy Serum/Plasma Advanced, and the ExoRNeasy Maxi kit, respectively, in a plasma cohort of 27 NSCLC patients and 20 healthy individuals. Extracted miRNA was investigated using small RNA sequencing and hybridization platforms. Validation of the identified miRNA candidates was performed using quantitative PCR. RESULTS:We demonstrate the highest read counts in healthy individuals and NSCLC patients using QIAseq. Moreover, QIAseq showed 15.9% and 162.9% more cfmiRNA and EVmiRNA miRNA counts, respectively, in NSCLC patients compared to healthy control samples. However, a systematic comparison of selected miRNAs revealed little agreement between high-throughput platforms, thus some miRNAs are detected with one technology, but not with the other. Adding to this, 35% (9 of 26) of selected miRNAs in the cfmiRNA and 42% (11 of 26) in the EVmiRNA fraction were differentially expressed by at least one qPCR platform; about half of the miRNAs (54%) were concordant for both platforms. CONCLUSIONS:Changing of (pre)-analytical methods of miRNA analysis has a significant impact on blood test results and is therefore a major confounding factor. In addition, to confirm miRNA biomarker candidates screening studies should be followed by targeted validation using an independent platform or technology.

Published
2020

18. Multicenter Evaluation of Circulating Plasma MicroRNA Extraction Technologies for the Development of Clinically Feasible Reverse Transcription Quantitative PCR and Next-Generation Sequencing Analytical Work Flows

Author

Kloten, V, Neumann, MHD, Di Pasquale, F, Sprenger-Haussels, M, Shaffer, JM, Schlumpberger, M, Herdean, A, Betsou, F, Ammerlaan, W, Af Hällström, T, Serkkola, E, Forsman, T, Lianidou, E, Sjöback, R, Kubista, M, Bender, S, Lampignano, R, Krahn, T, Schlange, T, and CANCER-ID consortium

Subjects
Male, Reverse Transcriptase Polymerase Chain Reaction, High-Throughput Nucleotide Sequencing, Chemical Fractionation, Middle Aged, Real-Time Polymerase Chain Reaction, 1004 Medical Biotechnology, 1101 Medical Biochemistry and Metabolomics, 1103 Clinical Sciences, Extracellular Vesicles, Biomarkers, Tumor, Animals, Humans, Female, Circulating MicroRNA, Caenorhabditis elegans, General Clinical Medicine, Aged
Abstract

BACKGROUND: In human body fluids, microRNA (miRNA) can be found as circulating cell-free miRNA (cfmiRNA), as well as secreted into extracellular vesicles (EVmiRNA). miRNAs are being intensively evaluated as minimally invasive liquid biopsy biomarkers in patients with cancer. The growing interest in developing clinical assays for circulating miRNA necessitates careful consideration of confounding effects of preanalytical and analytical parameters. METHODS: By using reverse transcription quantitative real-time PCR and next-generation sequencing (NGS), we compared extraction efficiencies of 5 different protocols for cfmiRNA and 2 protocols for EVmiRNA isolation in a multicentric manner. The efficiency of the different extraction methods was evaluated by measuring exogenously spiked cel-miR-39 and 6 targeted miRNAs in plasma from 20 healthy individuals. RESULTS: There were significant differences between the tested methods. Although column-based extraction methods were highly effective for the isolation of endogenous miRNA, phenol extraction combined with column-based miRNA purification and ultracentrifugation resulted in lower quality and quantity of isolated miRNA. Among all extraction methods, the ubiquitously expressed miR-16 was represented with high abundance when compared with other targeted miRNAs. In addition, the use of miR-16 as an endogenous control for normalization of quantification cycle values resulted in a decreased variability of column-based cfmiRNA extraction methods. Cluster analysis of normalized NGS counts clearly indicated a method-dependent bias. CONCLUSIONS: The choice of plasma miRNA extraction methods affects the selection of potential miRNA marker candidates and mechanistic interpretation of results, which should be done with caution, particularly across studies using different protocols.

Published
2019

21. Monitoring Large Railways Infrastructures Using Hybrid Fbg/Raman Sensor Systems

Author

Velha, P., primary, Nannipieri, T., additional, Signorini, A., additional, Morosi, M., additional, Solazzi, M., additional, Barone, F., additional, Frisoli, A., additional, Ricciardi, L., additional, Giuliani, S., additional, Eusepi, R., additional, Icardi, M., additional, Recchia, G., additional, Lupi, M., additional, Arcoleo, G., additional, Firmi, P., additional, and Di Pasquale, F., additional

Published
2018
Full Text
View/download PDF

25. Er3+-doped BaY2F8 crystal waveguides for broadband optical amplification at 1.5 μm.

Author

Toccafondo, V., Cerqueira S., A., Faralli, S., Sani, E., Toncelli, A., Tonelli, M., and Di Pasquale, F.

Subjects
WAVEGUIDES, CRYSTALS, FINITE element method, METHODOLOGY, DATA, ABSORPTION, EMISSIONS (Air pollution), BANDWIDTHS, BASEBAND
Abstract

Integrated waveguide amplifiers based on high concentration Er3+ doped BaY2F8 crystals are numerically studied by combining a full-vectorial finite element based modal analysis and propagation-rate equations. Using realistic input data, such as the absorption/emission cross sections and Er level lifetimes measured on grown crystal samples, we investigate the amplifier performance by optimizing the total Er concentration. We predict optimum gain coefficient up to 5 dB/cm and broad amplification bandwidth exceeding 80 nm with 1480 nm pumping. [ABSTRACT FROM AUTHOR]

Published
2007
Full Text
View/download PDF

26. Bidirectional Transmission in an Optical Network on Chip With Bus and Ring Topologies

Author

Faralli, S., Gambini, Fabrizio, Pintus, P., Scaffardi, M., Liboiron-Ladouceur, O., Xiong, Y., Castoldi, P., and Di Pasquale, F.

Subjects
photonic integrated networks on chip (NoCs), Hardware_INTEGRATEDCIRCUITS, shared source-microring and shared destination-microring, adding or dropping two optical signals at the same wavelength in the same microring of NoCs with bus and ring topology, Hardware_PERFORMANCEANDRELIABILITY, simultaneous bidirectional transmissions
Abstract

In photonic integrated networks on chip (NoCs), microrings are commonly used for adding or dropping a single optical signal to be switched in the NoC. This paper demonstrates the feasibility of adding or dropping two optical signals at the same wavelength in the same microring of NoCs with bus and ring topology. More specifically, the same microring can be used to support simultaneous bidirectional transmissions of two signals to be coupled in the NoC topology, leading to two different configurations, called shared source-microring and shared destination-microring. Spectral characterization shows good agreement between simulations and measurements taken on silicon-based integrated NoC. Bit-error-rate (BER) measurements indicate that the shared sourcemicroring configuration performs better, achieving a penalty as low as 1.5 dB for a BER of 10 -9 at 10 Gb/s in the bus NoC. A higher penalty in the ring NoC for both configurations is due to higher crosstalk in the interconnecting ring

Published
2016
Full Text
View/download PDF

27. [Er.sup.3+]-doped Ba[Y.sub.2][F.sub.8] crystal waveguides for broadband optical amplification at 1.5 [micro]m

Author

Toccafondo, V., S. A. Cerqueira, Jr., Faralli, S., Sani, E., Toncelli, A., Tonelli, M., and Di Pasquale, F.

Subjects
Broadband amplifiers -- Usage, Erbium -- Mechanical properties, Waveguides -- Analysis, Physics
Abstract

A full-vectorial finite element based modal analysis and propagation-rate equations are used to study the integrated waveguide amplifiers based on high concentration [Er.sup.3+] doped Ba[Y.sub.2][F.sub.8] crystals. The numerical results have predicted optimum gain coefficient up to 5 dB/cm and broad amplification bandwidth exceeding 80 nm with 1480 nm pumping.

Published
2007

40. Silicon Photonics for Matrix Switching Applications: Ingredients and Recipes

Author

Oton, C. J., primary, Pintus, P., additional, Manganelli, C., additional, Gambini, F., additional, Di Pasquale, F., additional, Tondini, S., additional, Castellan, C., additional, Mancinelli, M., additional, Pavesi, L., additional, Kim, M. S., additional, Lee, J. M., additional, Fowler, D., additional, Fournier, M., additional, Kopp, C., additional, and Testa, F., additional

Published
2016
Full Text
View/download PDF

42. Effect of repaglinide administration on current perception in type II diabetic patients

Author

Barbato E, PASSAVANTI, Maria Beatrice, Di Pasquale F, PACE, Maria Caterina, Bologna C, PAOLISSO, Giuseppe, SANSONE, Pasquale, Cicciarella G, AURILIO, Caterina, Barbato, E, Passavanti, Maria Beatrice, Di Pasquale, F, Pace, Maria Caterina, Bologna, C, Paolisso, Giuseppe, Sansone, Pasquale, Cicciarella, G, and Aurilio, Caterina

Published
2005

45. Il target metabolico e la compliance nel diabetico anziano

Author

RIZZO, Maria Rosaria, Manzella D, BARBIERI, Michelangela, Abbatecola A, Grella R, Attanasio S, Bologna C, Quaranta E, Papa M, Di Pasquale F, PAOLISSO, Giuseppe, Rizzo, Maria Rosaria, Manzella, D, Barbieri, Michelangela, Abbatecola, A, Grella, R, Attanasio, S, Bologna, C, Quaranta, E, Papa, M, Di Pasquale, F, and Paolisso, Giuseppe

Published
2004

46. Integrated hybrid Raman/fiber Bragg grating interrogation scheme for distributed temperature and point dynamic strain measurements

Author

Zaidi F, Nannipieri T, Soto MA, Signorini A, Bolognini G, and Di Pasquale F

Subjects
Physics::Optics, FIBER, TECHNOLOGY
Abstract

We propose and experimentally demonstrate the feasibility of an integrated hybrid optical fiber sensing interrogation technique that efficiently combines distributed Raman-based temperature sensing with fiber Bragg grating (FBG)-based dynamic strain measurements. The proposed sensing system is highly integrated, making use of a common optical source/receiver block and exploiting the advantages of both (distributed and point) sensing technologies simultaneously. A multimode fiber is used for distributed temperature sensing, and a pair of FBGs in each discrete sensing point, partially overlapped in the spectral domain, allows for temperature-independent discrete strain measurements. Experimental results report a dynamic strain resolution of 7.8 n epsilon/root Hz within a full range of 1700 mu epsilon and a distributed temperature resolution of 1 degrees C at 20 km distance with 2.7 m spatial resolution.

Published
2012

47. Design of 980 nm-Pumped Waveguide Laser for Continuous Wave Operation in Ion Implanted Er:LiNbO3

Author

Sher SM, Pintus P, Di Pasquale F, Bianconi M, Montanari GB, De Nicola P, Sugliani S, and Prati G

Subjects
Physics::Optics
Abstract

Embedded channel waveguides formed on a z-cut erbium-doped lithium niobate (Er:LiNbO(3)) substrate by a high-energy ion implantation technique are first described. A detailed theoretical design of a waveguide laser for continuous wave operation is then discussed, taking into account realistic input parameters and measured data. To simulate waveguide modes and to predict laser outputs from our fabricated waveguide sample, a numerical tool is developed in FORTRAN based on the full vectorial finite element method. Using the developed tools, the waveguide dimension is optimized, ensuring single-mode operation at both pump (980 nm) and laser (1531 nm) wavelengths. Finally, laser outputs as a function of various waveguide parameters are analyzed. The proposed analysis allows the effective optimization of the ion-implanted waveguide laser in Er:LiNbO(3).

Published
2011

Catalog

Books, media, physical & digital resources
See catalog results