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Dermatofibrosarcoma protuberans is a very rare tumor, but it is considered the most common skin sarcoma. It originates in the dermis and tends to infiltrate underlying structures. Due to a high rate of misdiagnosis, it is usually discovered with local invasions, but metastases are rare. Wide local excision and adjuvant therapies such as Imatinib (Tyrosine Kinase Inhibitor) are used to both prevent and limit recurrences. Long term follow-up is strongly recommended. We present the case of a 51-year-old man who presented with multiple atypical nevi. The patient was diagnosed with dermatofibrosarcoma protuberans and mediastinal adenopaties seven years ago. The primary lesion was excised and he was prescribed chemotherapy with Paclitaxel and Carboplatin. Subséquent, he was diagnosed with a dermatofibrosarcoma protuberans pulmonary metastasis with fibrosarcomatous development, thus beginning treatment with Imatinib. From the patients's history, he was also diagnosed with in situ melanoma on the back which was excised, developed after initiating the treatment with Imatinib. Patients with fibrosarcomatous dermatqfibrosarcoma protuberans may need adjuvant therapy such as Imatinib in order to avoid a possible recurrence or to treat metastases. Dysplastic nevi proliferation may be associated with Imatinib therapy. Therefore, regular follow-ups are required in order to monitor both dermatofibrosarcoma protuberans recurrences, as well as atypic nevi at a patient with history of melanoma. [ABSTRACT FROM AUTHOR]

Introduction: The diagnosis of erythroderma is frequently challenging due to subtle clinical and paraclinical signs necessary to differentiate between a variety of underlying dermatoses, infections or systemic diseases. The management is also difficult, with severe systemic complications that impose an early medical intervention. Objective: We aimed to analyze the epidemiological, clinical, and therapeutic profile of patients diagnosed with erythroderma in a tertiary dermatology referral center from Romania. Materials and methods: We conducted a retrospective descriptive study of patients diagnosed with erythroderma in the Dermatology and Allergology Clinic, „Elias" Emergency University Hospital, Bucharest, Romania from January 2012 to August 2018. An in-depth analysis of the clinical, paraclinical, as well as therapeutic management was performed. Results: The most frequent cause of erythroderma was represented by the exacerbation of psoriasis, followed by other chronic inflammatory dermatoses, as well as by hypersensitivity reactions to drugs. Less frequently, erythroderma was a paraneoplastic manifestation or a clinical presentation of rare genetic or autoimmune pathologies. The therapeutic management led to favorable results, with the remission or the amelioration of the disease. Few patients needed supportive care. Conclusions: Although the prognosis of the majority of patients was favorable, it is important to take into consideration the possibility of an associated cancer diagnosis. The dermatologist plays an essential role within the multidisciplinary team involved in the diagnosis and management of erythroderma. [ABSTRACT FROM AUTHOR]

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Atopic dermatitis is an inflammatory skin disease, characterized by periods of exacerbation and remission, which affects 15-30% of children and 2-10% of adults. It is known that atopic dermatitis is caused by an abnormal skin barrier (physical, chemical and immunological). In addition, new studies have shown that an important role in the pathophysiology of atopic dermatitis is the altered skin microbiota. This review highlights the recent observations regarding the changes of the skin microbiome in atopic dermatitis and possible therapeutic options for this disease. [ABSTRACT FROM AUTHOR]

Hidradenitis suppurativa represents a chronic, recurrent inflammatory disease, characterized by the formation of painful abscesses, sinuous tracts, foul smelling secretions, vicious scaring, with a severe reduction of the patients' quality of life. The pathophysiology of hidradenitis suppurativa is complex, follicular hyperkeratosis being regarded as the main pathogenetic mechanism. Bacterial colonization and follicular dysbiosis are of secondary importance in the pathogenesis of the disease, by triggering immunemediated inflammation. The formation of bacterial biofilms in sinuous tracts inhibits the efficacy of antibiotics, thus inducing chronic lesions. This article aims to highlight the role of bacterial colonization in the pathophysiology of hidradenitis suppurativa, as well as therapeutic options that act by regulating follicular dysbiosis. [ABSTRACT FROM AUTHOR]

Acne vulgaris is a disorder of the pilosebaceous unit that affects approximately 85% of teenagers. There are multiple factors involved in the pathogenesis, among which an imbalance in the skin microbiota, with an increased representation of Cutibacterium (former Propionibacterium) acnes, that activates innate immunity and leads to chronic inflammation. This review highlights recent observations regarding the influence of different Cutibacterium acnes phylotypes in acne and the importance of antimicrobial resistance of acne-associated strains. [ABSTRACT FROM AUTHOR]