1. Meta-analysis identifies novel risk loci and yields systematic insights into the biology of male-pattern baldness
- Author
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George Dedoussis, Rui Li, Elaine G.Y. Chew, George Papanikolaou, Tim D. Spector, David A. Hinds, Susanne Moebus, Asif Javed, Dale R. Nyholt, Axel M. Hillmer, Gérard Waeber, Zoltán Kutalik, Nicholas G. Martin, Michael P. Philpott, Lara M. Hochfeld, Tessel E. Galesloot, Xiu Ting Heng, Rico Rueedi, Thomas Anhalt, Markus M. Nöthen, Dmitriy Drichel, Michael Nothnagel, Stavroula Kanoni, Ralf Paus, Lambertus A. Kiemeney, Christine Herold, Stefanie Heilmann-Heimbach, J. Brent Richards, Tim Becker, Panos Deloukas, Peter Vollenweider, Julian Hecker, Sonali Pechlivanis, Ricardo C.H. del Rosario, Heide Loehlein Fier, and Shyam Prabhakar
- Subjects
0301 basic medicine ,Male ,Candidate gene ,genetics [Trans-Activators] ,SRD5A2 protein, human ,Medizin ,General Physics and Astronomy ,genetics [3-Oxo-5-alpha-Steroid 4-Dehydrogenase] ,Genome-wide association study ,Bioinformatics ,0302 clinical medicine ,genetics [Interferon Regulatory Factors] ,Genotype ,Melatonin ,Genetics ,Multidisciplinary ,Adipogenesis ,EBF1 protein, human ,integumentary system ,genetics [Intercellular Signaling Peptides and Proteins] ,Phenotype ,FGF5 protein, human ,genetics [Membrane Proteins] ,030220 oncology & carcinogenesis ,Meta-analysis ,Urological cancers Radboud Institute for Health Sciences [Radboudumc 15] ,Interferon Regulatory Factors ,Intercellular Signaling Peptides and Proteins ,Male-pattern baldness ,ddc:500 ,Signal Transduction ,DKK2 protein, human ,Fibroblast Growth Factor 5 ,3-Oxo-5-alpha-Steroid 4-Dehydrogenase/genetics ,Adipogenesis/genetics ,Alopecia/genetics ,Case-Control Studies ,Fibroblast Growth Factor 5/genetics ,Genetic Association Studies ,Genome-Wide Association Study ,Humans ,Intercellular Signaling Peptides and Proteins/genetics ,Interferon Regulatory Factors/genetics ,Membrane Proteins/genetics ,Signal Transduction/genetics ,Trans-Activators/genetics ,Science ,Genomics ,Biology ,genetics [Signal Transduction] ,General Biochemistry, Genetics and Molecular Biology ,Article ,03 medical and health sciences ,interferon regulatory factor-4 ,3-Oxo-5-alpha-Steroid 4-Dehydrogenase ,medicine ,genetics [Adipogenesis] ,genetics [Alopecia] ,Case-control study ,Membrane Proteins ,Alopecia ,General Chemistry ,medicine.disease ,genetics [Fibroblast Growth Factor 5] ,030104 developmental biology ,Trans-Activators - Abstract
Male-pattern baldness (MPB) is a common and highly heritable trait characterized by androgen-dependent, progressive hair loss from the scalp. Here, we carry out the largest GWAS meta-analysis of MPB to date, comprising 10,846 early-onset cases and 11,672 controls from eight independent cohorts. We identify 63 MPB-associated loci (P, Male-pattern baldness is a common condition in which hair is progressively lost from the scalp. Here, the authors find 23 new genetic variants associated with this condition and suggest that it is not an isolated trait but may share an underlying biological basis with various diseases.
- Published
- 2017
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