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Objective To observe the blood type antibody titer abnormal proportion in pregnant women and its relationship with newborns hemolytic disease, so as to provide the basis for prevention of the ABO newborns hemolytic disease. Method Microcolumn gel card method (MGT) was used to detect IgG antibody titer of anti A or anti B in ABO blood type. Result Of the 2580 cases of pregnant women, the serum antibody titer ≥ 1:64 was found in 1944 cases, the abnomal detection rate was 75.35%. Conclusion The incidence of ABO newborns hemolytic disease is positively correlated with the level of IgG antibody titer during pregnancy. With the increase of IgG antibody titer, the incidence of ABO hemolytic disease increases. Regular detection of IgG antibody titer during pregnancy has a certain predictability in the diagnosis of HDN. The study has important significance in reducing the incidence of HDN, which can be attained through early monitoring and effectively controlling the antibody titer during the pregnancy. [ABSTRACT FROM AUTHOR]