1. Serum Glycomics on Postoperative Day 7 Are Associated With Graft Loss Within 3 Months After Liver Transplantation Regardless of Early Allograft Dysfunction
- Author
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Anja Geerts, Arnaud Vanlander, Frederik Berrevoet, Luis Abreu de Carvalho, Hans Van Vlierberghe, Nico Callewaert, Leander Meuris, Roos Colman, Helena Degroote, Xavier Rogiers, and Xavier Verhelst
- Subjects
PREDICTOR ,medicine.medical_specialty ,CLEARANCE ,medicine.medical_treatment ,Liver transplantation ,Gastroenterology ,DISEASE ,RETRANSPLANTATION ,Risk Factors ,Internal medicine ,Medicine and Health Sciences ,medicine ,FAILURE ,Humans ,Prospective Studies ,Prospective cohort study ,Glycomics ,Retrospective Studies ,Transplantation ,business.industry ,MORTALITY ,Graft Survival ,Area under the curve ,Odds ratio ,Allografts ,Confidence interval ,Liver Transplantation ,MODEL ,Cohort ,SURVIVAL ,Biomarker (medicine) ,business ,DONOR-RISK-INDEX ,MELD-SCORE - Abstract
Background. Prediction of outcome after liver transplantation (LT) is limited by the lack of robust predictors of graft failure. In this prospective study, we aimed to define a serum glycomic signature in the first week after LT that is associated with graft loss at 3 mo after LT. Methods. Patients were included between January 1, 2011, and February 28, 2017. Glycomic analysis was performed using DNA sequencer-associated fluorophore-associated capillary electrophoresis on a serum sample 1 wk after LT. Making use of Lasso regression, an optimal glycomic signature was identified associated with 3-mo graft survival. Results. In this cohort of 131 patients, graft loss at 3 mo occurred in 14 patients (11.9%). The optimal mode, called the GlycoTransplantTest, yielded an area under the curve of 0.95 for association with graft loss at 3 mo. Using an optimized cutoff for this biomarker, sensitivity was 86% and specificity 89%. Negative predictive value was 98%. Odds ratio for graft loss at 3 mo was 70.211 (P < 0.001; 95% confidence interval, 10.876-453.231). Conclusions. A serum glycomic signature is highly associated with graft loss at 3 mo. It could support decision making in early retransplantation.
- Published
- 2020