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28 results on '"Da Prada, Gian Antonio"'

2. Adjuvant High-Dose Chemotherapy with Autologous Hematopoietic Stem Cell Support for High-Risk Primary Breast Cancer: Results from the Italian National Registry

Author

Pedrazzoli, Paolo, Martinelli, Giovanni, Gianni, Alessandro Massimo, Da Prada, Gian Antonio, Ballestrero, Alberto, Rosti, Giovanni, Frassineti, Giovanni Luca, Aieta, Michele, Secondino, Simona, Cinieri, Saverio, Fedele, Roberta, Bengala, Carmelo, Bregni, Marco, Grasso, Donatella, De Giorgi, Ugo, Lanza, Francesco, Castagna, Luca, Bruno, Barbara, and Martino, Massimo

Published
2014
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4. Adjuvant Ovarian Suppression in Premenopausal Breast Cancer

Author

Francis, Prudence A., Regan, Meredith M., Fleming, Gini F., Láng, István, Ciruelos, Eva, Bellet, Meritxell, Bonnefoi, Hervé R., Climent, Miguel A., Da Prada, Gian Antonio, Burstein, Harold J., Martino, Silvana, Davidson, Nancy E., Geyer, Charles E., Jr., Walley, Barbara A., Coleman, Robert, Kerbrat, Pierre, Buchholz, Stefan, Ingle, James N., Winer, Eric P., Rabaglio-Poretti, Manuela, Maibach, Rudolf, Ruepp, Barbara, Giobbie-Hurder, Anita, Price, Karen N., Colleoni, Marco, Viale, Giuseppe, Coates, Alan S., Goldhirsch, Aron, and Gelber, Richard D.

Published
2015
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6. Prognostic factors for survival in patients with advanced renal cell carcinoma undergoing nonmyeloablative allogeneic stem cell transplantation

Author

Peccatori, Jacopo, Barkholt, Lisbeth, Demirer, Tanner, Sormani, Maria Pia, Bruzzi, Paolo, Ciceri, Fabio, Zambelli, Alberto, Da Prada, Gian Antonio, Pedrazzoli, Paolo, Siena, Salvatore, Massenkeil, Gero, Martino, Rodrigo, Lenhoff, Stig, Corradini, Paolo, Rosti, Giovanni, Ringden, Olle, Bregni, Marco, and Niederwieser, Dietger

Published
2005
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8. Allogeneic blood stem cell transplantation after a reduced-intensity, preparative regimen

Author

Pedrazzoli, Paolo, Da Prada, Gian Antonio, Giorgiani, Giovanna, Schiavo, Roberta, Zambelli, Alberto, Giraldi, Eugenia, Landonio, Giuseppe, Locatelli, Franco, Siena, Salvatore, and Della Cuna, Gioacchino Robustelli

Subjects
Cancer -- Research, Medical research -- Analysis, Stem cells -- Transplantation, Tumors -- Genetic aspects, Carcinoma, Renal cell -- Research, Antigens -- Physiological aspects, Health
Published
2002

14. Adjuvant high-dose chemotherapy with autologous hematopoietic stem cell transplantation for high-risk breast cancer: results from the italian National Registry

Author

Pedrazzoli, Paolo, Martinelli, Giovanni, Gianni, Alessandro Massimo, Da Prada, Gian Antonio, Ballestrero, Alberto, Rosti, Giovanni, Frassineti, Giovanni Luca, Aieta, Michele, Secondino, Simona, Cinieri, Saverio, Fedele, Roberta, Bengala, Carmelo, Bregni, Marco, Grasso, Donatella, De Giorgi, Ugo, Lanza, Francesco, Castagna, Luca, Bruno, Barbara, Martino, Massimo, and Gruppo Italiano per il Trapianto di Midollo Osseo, Cellule staminali emopoietiche e terapia cellulare

Subjects
NO
Published
2014

15. Trabectedin and indole-3-carbinol combination in heavily pretreated metastatic breast cancer: Results of a pilot clinical study.

Author

Zambelli, Alberto, primary, Tancredi, Richard, additional, Negri, Sara, additional, Cattrini, Carlo, additional, Ponchio, Luisa, additional, Frascaroli, Mara, additional, Da Prada, Gian Antonio, additional, Fregoni, Vittorio, additional, Pavesi, Lorenzo, additional, Riccardi, Alberto, additional, Zucchetti, Massimo, additional, Fuso Nerini, Ilaria, additional, and D'Incalci, Maurizio, additional

Published
2014
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19. Ex vivo generation and expansion of anti-tumor cytotoxic T-cell lines derived from patients or their HLA-identical sibling

Author

Montagna, Daniela, primary, Schiavo, Roberta, additional, Gibelli, Nadia, additional, Pedrazzoli, Paolo, additional, Tonelli, Roberto, additional, Pagani, Sara, additional, Assirelli, Elisa, additional, Locatelli, Franco, additional, Pession, Andrea, additional, Fregoni, Vittorio, additional, Montini, Elisa, additional, Da Prada, Gian Antonio, additional, Siena, Salvatore, additional, and Maccario, Rita, additional

Published
2004
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28. Evaluation of infectious complications and immune recovery following high-dose chemotherapy (HDC) and autologous peripheral blood progenitor cell transplantation (PBPC-T) in 148 breast cancer patients.

Author

Zambelli A, Montagna D, Da Prada GA, Maccario R, Zibera C, Moretta A, Ponchio L, Lozza L, Baiardi P, Maserati R, Marone P, and Della Cuna GR

Subjects
Adult, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Bacteremia etiology, Breast Neoplasms drug therapy, Breast Neoplasms immunology, Breast Neoplasms virology, Dose-Response Relationship, Drug, Female, Gram-Negative Bacterial Infections immunology, Gram-Positive Bacterial Infections immunology, Herpes Zoster immunology, Herpesvirus 3, Human physiology, Humans, Immunity, Cellular drug effects, Immunity, Cellular immunology, Middle Aged, Neutropenia microbiology, Retrospective Studies, T-Lymphocyte Subsets drug effects, T-Lymphocyte Subsets immunology, T-Lymphocytes immunology, Virus Activation, Antineoplastic Combined Chemotherapy Protocols adverse effects, Breast Neoplasms microbiology, Gram-Negative Bacterial Infections etiology, Gram-Positive Bacterial Infections etiology, Herpes Zoster etiology, Peripheral Blood Stem Cell Transplantation adverse effects
Abstract

Background and Objectives: High-dose chemotherapy (HDC) with autologous PBPC-T has been reported to be effective in hematological and in selected solid malignancies. In this setting, infectious complications represent a relevant cause of morbidity., Patients and Methods: To ascertain the incidence, types and factors influencing the development of early and late infections, we retrospectively analyzed 148 consecutive breast cancer (BC) patients receiving HDC and PBPC-T, both for primary high-risk BC (pBC) and metastatic disease (mBC)., Results: Early infection strongly associated with the occurrence of grade 4 mucositis (p < 0.001), was documented in 28 patients (19%). Late re-activation of varicella zoster virus (VZV) occurred in 14 patients (9%); an inverse correlation between the VZV re-activation and the total amount of T-cells transferred with the graft was observed. Evaluation of immune reconstitution, carried out in 10 out of 148 patients, showed a long-lasting CD+ T-cells depression (> 2 year), mainly involving the naive CD4+ T-cell subset. Conversely, the analysis of the frequency of proliferating T-lymphocyte precursors, specific for antigens expressed by 3 different widespread pathogens, demonstrated that, notwithstanding the delayed recovery of CD4+ cells, many T-lymphocyte functions were within normal range 1 year after PBPC-T., Conclusion: Altogether these results show that severe mucositis is associated with early bacterial infections and the infusion of large numbers of T-cells plays a role in controlling late VZV reactivation.

Published
2002

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