1. Serum phospholipid omega-3 polyunsaturated fatty acids and insulin resistance in type 2 diabetes mellitus and non-alcoholic fatty liver disease
- Author
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Da-jun Lou, Qiao-ying You, Xu-wei Si, Duo Li, Li-li Guan, Qi-qian Zhu, Zhong-ming Yu, and Ai-zhen Zhang
- Subjects
Male ,medicine.medical_specialty ,endocrine system diseases ,Endocrinology, Diabetes and Metabolism ,Disease ,digestive system ,Endocrinology ,Insulin resistance ,Non-alcoholic Fatty Liver Disease ,Diabetes mellitus ,Internal medicine ,Fatty Acids, Omega-3 ,Internal Medicine ,Humans ,Medicine ,Phospholipids ,Aged ,chemistry.chemical_classification ,business.industry ,Fatty liver ,nutritional and metabolic diseases ,Type 2 Diabetes Mellitus ,Serum phospholipid ,Middle Aged ,medicine.disease ,digestive system diseases ,Diabetes Mellitus, Type 2 ,chemistry ,Case-Control Studies ,Female ,Insulin Resistance ,business ,Homeostasis ,Polyunsaturated fatty acid - Abstract
To investigate the relationship between serum phospholipid omega-3 polyunsaturated fatty acids (ω-3 PUFAs) and insulin resistance (IR) in patients with type 2 diabetes mellitus (T2DM) and non-alcoholic fatty liver disease (NAFLD).51 patients with T2DM and NAFLD (T2DM+NAFLD group), 50 with T2DM alone (T2DM group), 45 with NAFLD alone (NAFLD group), and 42 healthy control subjects (NC group) were studied. Serum ω-3 PUFA profiles were analyzed by gas chromatography, and alanine aminotransferase (ALT), aspartate aminotransferase (AST), γ-glutamyltransferase (GGT), and serum lipid concentrations were measured. Insulin resistance was assessed by the homeostasis model assessment method (HOMA-IR).HOMA-IR levels were higher in the T2DM+NAFLD group than in the T2DM, NAFLD and NC groups (p0.05), as were ALT, AST, GGT, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglyceride (TG) concentrations (p0.05). Conversely, serum ω-3 PUFA levels were significantly lower in the T2DM+NAFLD group than in the other groups (p0.05). The ω-3 PUFA level was negatively correlated with HOMA-IR, TC, LDL-C and TG.Serum phospholipid ω-3 PUFA levels were significantly decreased in patients with T2DM and NAFLD, and were negatively related with insulin resistance. Thus, reduced ω-3 PUFAs may play an important role in the development of T2DM and NAFLD.
- Published
- 2014