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137 results on '"Daemi, Hamed"'

37. Bead‐free and tough electrospun PCL/gelatin/PGS ternary nanofibrous scaffolds for tissue engineering application.

Author

Behtouei, Ebrahim, Zandi, Mojgan, Askari, Fahimeh, Daemi, Hamed, Zamanlui, Soheila, Arabsorkhi‐Mishabi, Amirhesam, and Pezeshki‐Modaress, Mohamad

Subjects
TISSUE engineering, GELATIN, TISSUE scaffolds, NERVE tissue, NANOFIBERS manufacturing, STRUCTURAL stability, TENSILE strength
Abstract

Poly(glycerol sebacate) (PGS) is a biodegradable and biocompatible polyester that is increasingly used in the biomedical field. Herein, a novel ternary poly(ε‐caprolactone)/gelatin/PGS (PCL/gelatin/PGS) blend nanofibers were designed and fabricated with a wide range of chemical compositions, mechanical properties, and modulated degradability levels. PGS blends with gelatin are commonly used for enhancing electrospinability but their low‐mechanical properties, lack of structural stability in an aqueous medium, and unmodulated degradation behavior limited their application. Blending PGS and gelatin with PCL could improve their properties in a ternary structure. In addition, considering ternary blends of PCL/gelatin/PGS, an enhancement of hydrophilicity due to the presence of gelatin in the system is expected, resulting in better biocompatibility and controlled biodegradation. By increasing the polymer concentration, voltage, and distance of the needle to the collector, the bead‐free electrospun nanofibers were obtained. The ternary blend nanofibers with an equal weight ratio of polymers, T33 (containing 33 wt% PGS, 33 wt% gelatin, and 33 wt% PCL), possess more than a 4‐fold increase in tensile strength (7 MPa) and 89‐fold increase in elongation at break (1760.6%) compared to gelatin/PGS binary nanofibers. In vitro studies on glioma cells showed well attachment and proliferation of C6 glioma cells. The obtained results demonstrated the potential of these scaffolds for nerve tissue engineering applications. [ABSTRACT FROM AUTHOR]

Published
2022
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38. Assessment of the Efficacy of Tributylammonium Alginate Surface-Modified Polyurethane as an Antibacterial Elastomeric Wound Dressing for both Noninfected and Infected Full-Thickness Wounds

Author

Hosseini Salekdeh, Seyyedeh Sahar, primary, Daemi, Hamed, additional, Zare-Gachi, Maryam, additional, Rajabi, Sarah, additional, Bazgir, Farhad, additional, Aghdami, Nasser, additional, Nourbakhsh, Mohammad Sadegh, additional, and Baharvand, Hossein, additional

Published
2019
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39. Electrospun nanofibrous alginate sulfate scaffolds promote mesenchymal stem cells differentiation to chondrocytes.

Author

Irani, Shiva, Tavakkoli, Sajjad, Pezeshki-Modaress, Mohamad, Taghavifar, Elham, Mohammadali, Marjan, and Daemi, Hamed

Subjects
MESENCHYMAL stem cell differentiation, ALGINIC acid, MESENCHYMAL stem cells, SULFATES, CARTILAGE cells, ENDOCHONDRAL ossification
Abstract

Cartilage tissue engineering is one of the interesting approaches used for repairing cartilage injuries. This study reports the fabrication of polyvinyl alcohol/alginate sulfate (PVA/ALG-S) nanofibrous mats as a functional support for chondrogenic differentiation of human bone marrow mesenchymal stem cells (hBM-MSCs). The PVA/ALG-S nanofibers were obtained through electrospinning of PVA solutions containing 10, 20, and 30 wt% of ALG-S. The appearance of a band at 833 cm−1 assigned to the symmetrical C O S vibration associated to a C O SO3 group confirmed the presence of ALG-S in nanofibrous mat. The SEM images illustrated the bead-free and smooth morphology of PVA/ALG-S nanofibers with a mean diameter of 185 ± 0.06 nm. The MTT assay of the hBM-MSCs seeded on scaffolds indicated the appropriate cytocompatibility of nanofibrous PVA/ALG-S scaffolds. Furthermore, the appropriate attachment and spreading of the hBM-MSCs based on SEM images, and their differentiation to the chondrocyte-like cells accompanied by a decrease in cell growth on MTT analysis and more color absorption in alician blue staining indicated the effective role of alginate sulfate on cell differentiation. Finally, the expression of Type II collagen by RT-PCR and immunocytochemistry analyses revealed the chondrogenic differentiation of hBM-MSCs on alginate sulfate nanofibers. [ABSTRACT FROM AUTHOR]

Published
2021
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