164 results on '"Dagdelen S"'
Search Results
2. Determinants of peak oxygen pulse in disorders of glucose metabolism
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Karaduz, B, primary, Bozdemir-Ozel, C, additional, Calik Kutukcu, E, additional, Arikan, H, additional, and Dagdelen, S, additional
- Published
- 2022
- Full Text
- View/download PDF
3. Impact of proactive low-molecular weight heparin therapy on outcomes in COVID-19
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Gormez, S., Gumusel, H. K., Ekicibasi, E., Degirmencioglu, A., Paudel, A., Akan, G., Atalar, F., Erdim, R., Eroglu, E., Dagdelen, S., Sariguzel, N., Kirisoglu, C. E., Pamukcu, B., and Acibadem University Dspace
- Subjects
SARS-CoV-2 ,D-dimer ,COVID-19 ,antithrombotic therapy ,enoxaparin ,low-molecular-weight heparin ,thrombosis - Abstract
OBJECTIVES: Low molecular weight heparin (LMWH) may provide beneficial effects on outcomes of COVID-19. We aimed to examine the impact of LMWH treatment on clinical outcomes (duration of hospitalization, admission to intensive care unit, the requirement for mechanical ventilation, and death) of COVID-19 patients with normal D-dimer levels at admission. BACKGROUND: Coronavirus disease-2019 (COVID-19) predisposes patients to arterial and venous thrombosis. METHODS: In this retrospective, multicentre and observational study we analysed the data of 308 confirmed COVID-19 patients with normal D-dimer levels at initial admission. After propensity score matching (PSM) patients were grouped
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- 2021
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4. No association of anti-osteoporosis drugs with COVID-19-related outcomes in women: a nationwide cohort study
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Atmaca, A., primary, Demirci, I., additional, Haymana, C., additional, Tasci, I., additional, Sahin, I., additional, Cakal, E., additional, Ata, N., additional, Dagdelen, S., additional, Salman, S., additional, Emral, R., additional, Sahin, M., additional, Celik, O., additional, Demir, T., additional, Ertugrul, D., additional, Unluturk, U., additional, Caglayan, M., additional, Satman, I., additional, and Sonmez, A., additional
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- 2021
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5. Maternal fetal medicine-perinatology
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Tekcan, C., Naki, M. M., Özcan, N., Cebi, M., Kanadikirik, F., Has, R., Aydoadu, M., Frenz, J. P., Schröder, W., Dede, F. S., Kovalak, E. E., Gelisen, O., Dede, H., Sariisik, B., Haberal, A., Caliskan, E., Turkoz, E., Corakci, A., Ozeren, S., Yucesoy, I., Terzioglu, N., Köhler, W., Feige, A., Atad, J., Auslender, R., Bardicef, M., Calderon, I., Leron, E., Abramovici, H., Ertas, I. F., Kahyaoglu, S., Turgay, M., Sut, N., Yilmaz, B., Ozel, M., Danisman, N., Kocak, I., Üstün, C., Bese, E., Ingec, M., Borekci, B., Yilmaz, M., Kadanali, S., Ingec, M., Kadanali, S., Erdogan, F., Kumtepe, Y., Gümüs, I. I., Turhan, N. O., Tamburaci, E., Gunduz, O., Akar, M., Simsek, M., Zorlu, G., Ingec, M., Borekci, B., Kadanali, S., Balci, O., Gezginc, K., Acar, A., Akyürek, C., Kocak, I., Üstün, C., Bese, E., Biri, A., Guler, I., Himmetoglu, O., Karaoguz, M. Y., Balci, Sevim, Tanriverdi, H. A., Usal, D., Cinar, E., Barut, A., Pilanci, B., Imren, A., Öztekin, D., Kurt, S., Tinar, S., Canoruc, N., Kale, A., Kale, E., Yalinkaya, A., Akdeniz, N., Gol, M., Tuna, B., Guclu, S., Altunyurt, S., Demir, N., Biri, A., Ciftci, B., Senol, E., Haznedarohlu, S., Gucuyener, K., Gursoy, R., Kahyaoglu, S., Turgay, I., Gocmen, M., Yilmaz, B., Neslihanoglu, R., Danisman, N., Kahyaoglu, S., Turgay, I., Gocmen, M., Yilmaz, B., Ozel, M., Danisman, N., Kahyaoglu, S., Turgay, I., Kokanali, M. K., Kunt, C., Yapar, E. G., Taskin, S., Yarci, A., Bozaci, E. A., Atabekoglu, C., Söylemez, F., Taskin, S., Seval, M., Bozaci, E. A., Özmen, B., Mammadova, S., Unlü, C., Seval, M., Taskin, S., Özmen, B., Güleryüz, D., Sahincioglu, Ö., Unlü, C., Öztürk, N., Yalvac, S., Caliskan, E., Erten, A., Dölen, I., Haberal, A., Gul, A., Cebeci, A., Gedikbasi, A., Erol, O., Ceylan, Y., Tekirdag, A. I., Onan, M. A., Turp, A., Kurdoglu, M., Gunaydin, G., Kurdoglu, Z., Guler, I., Erdem, A., Himmetoglu, O., Tulumbaci, O., Onan, M. A., Turkoglu, S., Kurdoglu, M., Boyaci, B., Tiras, M. B., Kurdoglu, Z., Gunaydin, G., Kadayifci, O., Demir, S. C., Ürünsak, I. F., Özgünen, T., Evrüke, I. C., Demir, S. C., Evrüke, I. C., Özgünen, T., Kadayifci, O., Güzel, A. B., Urünsak, I. F., Uckuyu, A., Ozcimen, E. E., Nisanoglu, O., Yanik, F., Akgun, S., Kuscu, E., Sayin, N. C., Canda, M. T., Ahmet, N., Kurt, I., Varol, F. G., Erkanli, S., Caliskan, K., Bagis, T., Kilicdag, E., Tarim, E., Kuscu, E., Tutuncu, L., Ardic, N., Mungen, E., Ergur, A. R., Yergok, Y. Z., Cölcimen, N., Sahin, H. G., Kamaci, M., Bezircioglu, I., Bicer, M., Uysal, D., Yigit, S., Baloglu, A., Bezircioglu, I., Bicer, M., Karci, L., Ozder, F., Baloglu, A., Has, R., Yüksel, A., Büyükkurt, S., Tatli, B., Kalelioglu, I., Kesim, M. D., Aydin, Y., Atis, A., Gezer, A., Erkan, S., Simsek, Y., Kahraman, N., Uludag, S., Altinok, T., Kale, A., Erdemoglu, M., Akdeniz, N., Ozcan, Y., Yalinkaya, A., Köse, G., Tuncel, T., Aka, N., Kumru, P., Güven, M. A., Ciragil, P., Tutuncu, L., Ozdemir, E., Mungen, E., Ergur, A. R., Yergok, Y. Z., Güven, M. A., Aktan, E., Bozkurt, K., Güven, M. A., Kilinc, M., Ekerbicer, H., Güven, M. A., Ceylaner, S., Ceylaner, G., Gul, D., Ertas, E., Güven, M. A., Ceylaner, S., Batukan, C., Ozbek, A., Demirpolat, G., Uzel, M., Basaran, A., Bozdag, G., Dagdelen, S., Gürlek, A., Beksac, S., Arici, Özkan A., Isparta, T., Dikis, F. C., Civas, S. B., Ispahi, C., Kalelioalu, I. K., Has, R., Yüksel, A., Gilbaz, E., Ibrahimoglu, L., Ermis, H., Yildirim, A., Dane, B., Yayla, M., Dane, C., Özek, M., Kalelioglu, I. K., Has, R., Yüksel, A., Gilbaz, E., Ibrahimoglu, L., Ermis, H., Yildirim, A., Dane, B., Yayla, M., Cem, Dane, Salih, Dural, Dane, C., Yayla, M., Dane, B., Cetin, A., Kiray, M., Dane, B., Yayla, M., Dane, C., Ataoglu, E., Döventas, Y., Delier, H., Has, R., Kalelioglu, I., Büyükkurt, S., Has, R., Kalelioglu, I. K., Yüksel, A., Gilbaz, E., Ibrahimoglu, L., Ermis, H., Yildirim, A., Has, R., Kalelioglu, I. K., Yüksel, A., Gilbaz, E., Ibrahimoglu, L., Ermis, H., Yildirim, A., Yildiz, A., Köksal, A., Celik, N., Yetimalar, H., Keklik, A., Ivit, H., Cukurova, K., Hizli, D., Dilbaz, S., Acer, N., Deveci, S., Dilbaz, B., Haberal, A., Cukurova, K., Köksal, A., Yilmaz, S., Ivit, H., Yildiz, A., Yetimalar, H., Keklik, A., Bicer, Bulbul M., Karakaya, E., Pehlivan, M., Baloglu, A., Caliskan, E., Doger, E., Duman, C., Turker, G., Ozeren, S., Yucesoy, I., Caliskan, E., Doger, E., Cakiroglu, Y., Corakci, A., Ozeren, S., Caliskan, E., Turkoz, E., Ozeren, S., Corakci, A., Ozkan, S., Yucesoy, I., Caliskan, E., Cakiroglu, Y., Dundar, D., Doger, E., Caliskan, S., Ozeren, S., Cukurova, K., Köksal, A., Ivit, H., Yetimalar, H., Yildiz, A., Keklik, A., Aksakalli, V., Cukurova, K., Köksal, A., Önal, G., Yildiz, A., Ivit, H., Keklik, A., Yetimalar, H., Kesim, M. D., Demirkaya, B. Ö., Atis, A., Yavuz, M., Bozkurt, T., Ozyuncu, O., Bozdag, G., Salman, M. C., Durukan, T., Beksac, S., Onderoglu, L., Deren, O., Ayhan, A., Tufekci, C., Karalök, H., Ilter, E., Cil, L., Karalök, A. E., Akyol, H., Kesim, M. D., Demirkaya, B. Ö., Atis, A., Oruc, Ö., Ekin, M., Ülku, M., Caglar, P., Demirel, C., Güngör, T., Mollamahmutoglu, L., Usta, T., Özdemir, B., Ates, U., Numanoglu, N., Seyhan, A., Sidal, B., Akdeniz, N., Kale, A., Erdemoglu, M., Ozcan, Y., Yalinkaya, A., Ozdemir, B., Numanoglu, N., Usta, T., Ortakuz, S., Seyhan, A., Sidal, B., Seyhan, A., Numanoglu, N., Usta, T., Ortakuz, S., Öztarhan, A., Özdemir, B., Dogan, O., Ilbaz, S., Kovalak, E. E., Tarcan, A., Sariisik, B., Sivaslioglu, A., Haberal, A., Cinar, E., Tanriverdi, H. A., Akbulut, V., Sade, H., Barut, A., Dede, A., Özel, M., Günaydin, S., Ertas, E., Danisman, N., Mollamahmutoglu, L., Ates, U., Seyhan, A., Atmaca, U., Ortakuz, S., Ata, B., Akar, S., Sidal, B., Tanriverdi, H. A., Akbulut, V., Usal, D., Cinar, E., Barut, A., Vural, B., Özkan, S., Costur, P., Dalcik, H., Filiz, S., Yücesoy, I., Erdemoglu, E., Kolusari, A., Sahin, H. G., Kamaci, M., Sahin, A. V., Vural, B., Özkan, S., Tas, A., Dalcik, C., Dalcik, H., Yücesoy, G., Unlubilgin, E., Caliskan, E., Demir, B., Dilbaz, S., Sonmezer, M., Haberal, A., Erdem, M., Turp, A., Gunaydin, G., Erdem, A., Sade, H., Tanriverdi, H. A., Gezer, S., Bayar, Ü., Barut, A., Demir, B., Demir, F., Yayla, M., Api, O., Aygün, E., Kars, B., Cengizoglu, B., Bulut, S., Turan, C., Unal, O., Api, O., Ünal, O., Karageyim, Y. K., Balcik, O., Kara, Ö., Dogance, U., Akil, A., Api, M., Balsak, D., Avci, M. E., Elveren, B., Hanhan, M., Kayhan, K., Tinar, S., Ispahi, C., Mollamahmutoglu, L., Güngör, T., Özdal, B., Cavkaytar, S., Özat, M., Demirel, C., Aksakal, O., Caliskan, E., Unlubilgin, E., Cakiroglu, Y., Dilbaz, B., Dilbaz, S., Dilbaz, S., Caliskan, E., Dilbaz, B., Ozdas, E., Filiz, T., Haberal, A., Asian, E., Tarim, E., Kilicdag, E., Haydardedeoglu, B., Kuscu, E., Asian, E., Kilicdag, E., Simsek, E., Bolat, F., Haydardedeoglu, B., Ocak, S., Zeteroglu, S., Deveci, A., Gungoren, A., Borazan, E., Hakverdi, A., Zeteroglu, S., Ocak, S., Deveci, A., Gungoren, A., Andi, A., and Hakverdi, A.
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- 2005
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6. Probably Benign Breast Lesions Associated with Prolactinoma and/or Macroprolactinemia.
- Author
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Cavus, SA, primary, Dagdelen, S, additional, Soygur, IT, additional, Akpinar, MG, additional, Erbas, T, additional, and Usman, A, additional
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- 2010
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7. Impact of proactive low-molecular weight heparin therapy on outcomes in COVID-1
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Gormez, S., primary, Gumusel, H. K., additional, Ekicibasi, E., additional, Degirmencioglu, A., additional, Paudel, A., additional, Akan, G., additional, Atalar, F., additional, Erdim, R., additional, Eroglu, E., additional, Dagdelen, S., additional, Sariguzel, N., additional, Kirisoglu, C. E., additional, and Pamukcu, B., additional
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- 2021
- Full Text
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8. Simultaneous triple organ specific autoantibody profiling in adult patients with type 1 diabetes mellitus and their first-degree relatives*
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Dagdelen, S., Hascelik, G., and Bayraktar, M.
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- 2009
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9. EuroSCORE overestimates the cardiac operative risk
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Karabulut, H., Toraman, F., Alhan, C., Çamur, G., Evrenkaya, S., Dağdelen, S., and Tarcan, S.
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- 2003
- Full Text
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10. Liraglutide and Renal Outcomes in Type 2 Diabetes
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Mann JFE, Ørsted DD, Brown-Frandsen K, Marso SP, Poulter NR, Rasmussen S, Tornøe K, Zinman B, Buse JB, LEADER Steering Committee and Investigators. Bergenstal R, Daniels G, Moses AC, Nauck M, Nissen S, Pocock S, Steinberg W, Stockner M, Kristensen P, Ravn LS, Zychma M, Flyvbjerg A, Ford I, Kloos RT, Schactman MJ, Sleight P, Swedberg K, Tenner SM, Akalın S, Arechavaleta R, Bain S, Babkowski MC, Benroubi M, Berard L, Comlekci A, Czupryniak L, Eliasson B, Eriksson M, Fonseca V, Franek E, Gross J, Hafidh K, Haluzik M, Hayes F, Huang YY, Jacob S, Kaddaha G, Khalil A, Kilhovd B, Laakso M, Leiter L, Lalic N, Ji L, Luedemann J, Mannucci E, Marre M, Masmiquel L, Mota M, Omar M, O’Shea D, Pan C, Petrie J, Pieber T, Pratley R, Raz I, Rea R, Rutten G, Satman I, Shestakova M, Simpson R, Smith D, Tack C, Tarnow L, Thomas N, Van Gaal L, Travert F, Vidal J, Warren M, Yoon KH, Tuttle RM, Sheerman SI, Hegedüs L, Baerwald H, Bergenstal M, Celik S, Dias C, Eder M, Fitzgibbons S, Irvhage L, Kloluckova J, Kriulianski R, McDuffie R, Moen S, Paster A, Saalfeld RM, Sankar K, Shehaj E, Swierzewska P, Tiktin M, Tovey S, Gibson CM, Chakrabarti AK, Dashe JF, Hinchey J, Leary MC, Pride Y, Wiviott S, Allen S, Mehr AP, Mutter WP, Parikh S, Ray S, Cheifetz A, Leffler D, Sheth S, Alexander E, Gaglia JL, Goessling W, Mitzner LD, Rosenberg C, Snow KJ, Wagner A, Piazza G, Abell S, Davis T, D'Emden M, Ding SA, Gilfillan C, Greenaway T, Gunawan F, Ho J, Jackson R, Kalra B, Lau SL, Lin J, MacIsaac R, Makepeace A, Malabu U, Marjason J, McCallum R, McLean M, Moin N, Petersons C, Price S, Roberts A, Roberts D, Sangla K, Stranks S, Tan Y, Thynne T, Walters J, Ward G, Wen W, Zhang J, Brix J, Feder A, Höbaus C, Höllerl F, Höller V, Kotter T, Kratz E, Krzizek EC, Leb-Stoeger U, Mader J, Mras N, Novak E, Obendorf F, Peric S, Pesau G, Prager R, Ribitsch A, Schnack C, Schernthaner G, Wascher T, Batens AH, Benhalima K, De Block C, Ernest P, Fouckova A, Jandrain B, Lapauw B, Letiexhe M, Mathieu C, Neven S, Peiffer F, Ruige J, Scheen A, Taes Y, Van Boxelaer I, Vandistel G, Van Durme Y, Verhaegen A, Alencar E, Alencar R, Almeida AC, Alves B, Alves E, Alves G, Alves J, Araujo L, Arruda V, Augusto GA, Baggentoss R, Balestrassi L, Barbosa M, Barcelos I, Belem L, de Bem A, Betti RT, Bona R, Bosco A, Branda J, Bronstein M, Bueno T, Bulcão T, Caiado F, Camazzola F, Cambréa MF, Campos S, Canani L, Carra MK, Caruso S, Carvalho N, Casillo A, Castro D, Cavalcanti T, Cavichioli V, Cercato C, Chacra A, Challela W, Charchar HS, Chaves C, Chrisman C, Correia-Deur J, da Costa A Jr, Costa M, Costi B, Coutinho P, Coutinho W, Cunha MR, Daher J Jr, Davini E, Democh D Jr, Eliaschewitz F, Esmanhoto Facin G, Farias F, Felício J, Fernandes V, Filho CS, Filho FF, Filho M, Fontan D, Fontenele AP, Forti A, Franco D, Freire K, Fusaro A, Genestreti P, Gerchman F, Godi A, Gomes KF, Gonçalves P, Gonçalves R, Griz L, Grossman M, Gurgel MH, Vasconcellos Haddad AW, Halpern A, Hissa M, Inuy A, Jaime J, Jonasson T, Jorge JC, Malucelli FJ, Kohara S, Kramer C, Lacerda C, Ladeira S, Lana J, Lastebasse F, Leitão A, Leite S, Lerário AC, Lima D, Lima M, Lippi V, Lunardi M, Machado E, Maia F, Maia J, Maia KP, Mañas N, Marchisotti F, Marinho C, Martins C, Figueiredo de Medeiros F, Melo A, Melo F, Mendonca E, Mendonça P, Filho RM, Miguel M, Miléo K, Miyahara M, Montenegro AP, Moraes A, Moreira A, Ítalo Mota J, Mothe FS, Murro A, Nakatani V, Napoli TF, Neto BG, Neto OQ, Niclewicz E, Ohe LN, Oliveira F, Oliveira M, Panarotto D, Parente E, Parolin S, Pechmann L, Costa da Penha P, Perlamagna L, Perotta B, Pimentel L, Pinto M, Poço C, Ponte C, Prazeres P, Quintao E, Raduan R, Rassi DT, Rassi N, Reck L, Montenegro R Jr, Ribeiro R, Rodovalho S, Silveira Rodrigues G, Rollin G, Rossi S, Sabino C, Sales AP, Salles J, Sampaio CR, Santana L, Sato V, da Silva Santos M, Santos NL, Santos R, Saraiva J, Sartori C, Sena R, Sevilha M, Sgarbi J, Silva D, D'albuquerque Silva L, Silva ME, Siqueira K, Soares S, Sobreira W, Sousa B, Souza AC, Souza B, Tambascia M, Tarantino R, Tenor F, Tomarchio M, Triches C, Tristão LJ, Valenti A, Vasques E, Vencio S, Vianna A, Munhoz Vidotto T, Vieira S, Villar H, Visconti G, Volaco A, Wajchenberg B, Zanatta L, Zimmerman L, Abbott EC, Abu-Bakare A, Advani A, Allison R, Bishara P, Bowering CK, Cheng A, Chouinard S, Clayton D, Conway J, D'Amours M, de Tugwell B, DeYoung P, D'Ignazio G, Dube F, Ekoe JM, Fagan S, Garceau C, Gottesman I, Hanna A, Harris S, Hramiak IM, Hurd C, Imran S, Josse R, Joyce C, Kaiser S, Khan F, Kirouac I, Kovacs C, Labonte I, Langlois WJ, Levac MF, Liutkus J, McDonald C, Milosevic V, Nyomba BL, Paul T, Raby K, Ransom T, Reichert SM, Retnakaran R, Rabasa-Lhoret R, Raff E, Shaikholeslami R, Sigalas J, Yip CE, Weisnagel SJ, Woo V, Bao Y, Cai X, Chen J, Chen K, Chen M, Chen X, Chen Y, Ji Y, Lei J, Li H, Liu P, Mu Y, Ren M, Ren Y, Shi Y, Wang D, Wang F, Wang J, Wang Y, Yan L, Yang G, Yang J, Yu X, Yuan G, Xu M, Zhao X, Zheng J, Zhou L, Anderlová K, Brožová J, Haluzík M, Hanušová V, Kosák M, Křížová J, Mráz M, Owen K, Rušavý Z, Tomešová J, Trachta P, Žourek M, Andersen PH, Boesgaard T, Christensen S, Gram J, Gregersen S, Henriksen JE, Hermansen K, Jakobsen PE, Jensen J, Krogsaa A, Larsen M, Lervang HH, Madsbad S, Mortensen L, Olesen T, Pietraszek A, Ridderstråle M, Safai N, Schioldan AG, Schmidt C, Snorgaard O, Stidsen J, Cederberg H, Haapamäki H, Hukkanen J, Jauhiainen R, Kujari ML, Lahtela J, Laine M, Mäkelä J, Miilunpohja M, Savolainen M, Taurio J, Vänttinen M, Creton C, Cosma NV, Dillinger J, Jacques JL, Guedj AM, Moulla M, Petit C, Ratsianoharana V, Richter D, Rodier M, Roussel R, Hinz A, Politz E, Esser M, Deuse U, Mittag D, Hagenow A, Jacob F, Jordan R, Gantke D, Venschott-Jordan U, Löhr C, Klausmann G, Eschenbrücher K, Karakas M, Jahrsdörfer B, Kunze MR, Wöhrle J, König W, Spielhagen H, Kilimnik A, Lüdemann HP, Lüdemann J, Mölle A, Mölle M, Müller J, Appelt S, Sauter A, Sauter J, Hartmann U, Löw A, Krötz F, Sohn HY, von Schacky C, Klauss V, Braun D, Segner A, Degtyareva E, Kreutzmann K, Paschmionka R, Hauck N, Sihal O, Busch AK, Maus O, Stübler P, Füllgraf-Horst S, Vietzke A, Müller C, 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C, Wise J, Witte M, Wittenmyer J, Wood C, Wood R, Woodruff C, Worthington B, Wynn D, Wysham C, Xavier P, Yela S, Yenoby L, Young L, Younus N, Yourell V, Zaid M, Zubair I., Mann, Jfe, Ørsted, Dd, Brown-Frandsen, K, Marso, Sp, Poulter, Nr, Rasmussen, S, Tornøe, K, Zinman, B, Buse, Jb, Bergenstal R, LEADER Steering Committee and Investigators., Daniels, G, Moses, Ac, Nauck, M, Nissen, S, Pocock, S, Steinberg, W, Stockner, M, Kristensen, P, Ravn, L, Zychma, M, Flyvbjerg, A, Ford, I, Kloos, Rt, Schactman, Mj, Sleight, P, Swedberg, K, Tenner, Sm, Akalın, S, Arechavaleta, R, Bain, S, Babkowski, Mc, Benroubi, M, Berard, L, Comlekci, A, Czupryniak, L, Eliasson, B, Eriksson, M, Fonseca, V, Franek, E, Gross, J, Hafidh, K, Haluzik, M, Hayes, F, Huang, Yy, Jacob, S, Kaddaha, G, Khalil, A, Kilhovd, B, Laakso, M, Leiter, L, Lalic, N, Ji, L, Luedemann, J, Mannucci, E, Marre, M, Masmiquel, L, Mota, M, Omar, M, O’Shea, D, Pan, C, Petrie, J, Pieber, T, Pratley, R, Raz, I, Rea, R, Rutten, G, Satman, I, 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J, Feder, A, Höbaus, C, Höllerl, F, Höller, V, Kotter, T, Kratz, E, Krzizek, Ec, Leb-Stoeger, U, Mader, J, Mras, N, Novak, E, Obendorf, F, Peric, S, Pesau, G, Prager, R, Ribitsch, A, Schnack, C, Schernthaner, G, Wascher, T, Batens, Ah, Benhalima, K, De Block, C, Ernest, P, Fouckova, A, Jandrain, B, Lapauw, B, Letiexhe, M, Mathieu, C, Neven, S, Peiffer, F, Ruige, J, Scheen, A, Taes, Y, Van Boxelaer, I, Vandistel, G, Van Durme, Y, Verhaegen, A, Alencar, E, Alencar, R, Almeida, Ac, B, Alve, Alves, E, Alves, G, Alves, J, Araujo, L, Arruda, V, Augusto, Ga, Baggentoss, R, Balestrassi, L, Barbosa, M, Barcelos, I, Belem, L, de Bem, A, Betti, Rt, Bona, R, Bosco, A, Branda, J, Bronstein, M, Bueno, T, Bulcão, T, Caiado, F, Camazzola, F, Cambréa, Mf, Campos, S, Canani, L, Carra, Mk, Caruso, S, Carvalho, N, Casillo, A, Castro, D, Cavalcanti, T, Cavichioli, V, Cercato, C, Chacra, A, Challela, W, Charchar, H, C, Chave, Chrisman, C, Correia-Deur, J, da Costa, A Jr, Costa, M, Costi, B, Coutinho, P, 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S, Pechmann, L, Costa da Penha, P, Perlamagna, L, Perotta, B, Pimentel, L, Pinto, M, Poço, C, Ponte, C, Prazeres, P, Quintao, E, Raduan, R, Rassi, Dt, Rassi, N, Reck, L, Montenegro, R Jr, Ribeiro, R, Rodovalho, S, Silveira Rodrigues, G, Rollin, G, Rossi, S, Sabino, C, Sales, Ap, Salles, J, Sampaio, Cr, Santana, L, Sato, V, da Silva Santos, M, Santos, Nl, Santos, R, Saraiva, J, Sartori, C, Sena, R, Sevilha, M, Sgarbi, J, Silva, D, D'albuquerque Silva, L, Silva, Me, Siqueira, K, Soares, S, Sobreira, W, Sousa, B, Souza, Ac, Souza, B, Tambascia, M, Tarantino, R, Tenor, F, Tomarchio, M, Triches, C, Tristão, Lj, Valenti, A, Vasques, E, Vencio, S, Vianna, A, Munhoz Vidotto, T, Vieira, S, Villar, H, Visconti, G, Volaco, A, Wajchenberg, B, Zanatta, L, Zimmerman, L, Abbott, Ec, Abu-Bakare, A, Advani, A, Allison, R, Bishara, P, Bowering, Ck, Cheng, A, Chouinard, S, Clayton, D, Conway, J, D'Amours, M, de Tugwell, B, Deyoung, P, D'Ignazio, G, Dube, F, Ekoe, Jm, Fagan, S, Garceau, C, Gottesman, I, 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Male ,Settore MED/09 - Medicina Interna ,Acute Kidney Injury ,Aged ,Albuminuria ,Creatinine ,Diabetes Mellitus, Type 2 ,Diabetic Nephropathies ,Double-Blind Method ,Female ,Follow-Up Studies ,Glomerular Filtration Rate ,Glucagon-Like Peptide 1 ,Humans ,Hypoglycemic Agents ,Intention to Treat Analysis ,Kidney Failure, Chronic ,Liraglutide ,Middle Aged ,Type 2 diabetes ,030204 cardiovascular system & hematology ,urologic and male genital diseases ,GLOMERULAR-FILTRATION-RATE ,KIDNEY-FUNCTION ,DISEASE ,law.invention ,Kidney Failure ,chemistry.chemical_compound ,0302 clinical medicine ,Randomized controlled trial ,law ,Medicine ,Settore MED/49 - Scienze Tecniche Dietetiche Applicate ,Chronic ,RISK ,Kidney ,Acute kidney injury ,11 Medical And Health Sciences ,General Medicine ,medicine.anatomical_structure ,TRIAL ,liraglutide, randomized controlled trial, type 2 diabetes, renal outcomes ,Life Sciences & Biomedicine ,Type 2 ,medicine.drug ,medicine.medical_specialty ,Renal function ,030209 endocrinology & metabolism ,CARDIOVASCULAR OUTCOMES ,Follow-Up Studie ,03 medical and health sciences ,Medicine, General & Internal ,General & Internal Medicine ,Diabetes mellitus ,Internal medicine ,Diabetes Mellitus ,Intensive care medicine ,Science & Technology ,business.industry ,MORTALITY ,medicine.disease ,INTENSIVE GLUCOSE CONTROL ,INDIVIDUALS ,chemistry ,Diabetic Nephropathie ,LEADER Steering Committee and Investigators ,business - Abstract
BACKGROUND: In a randomized, controlled trial that compared liraglutide, a glucagon-like peptide 1 analogue, with placebo in patients with type 2 diabetes and high cardiovascular risk who were receiving usual care, we found that liraglutide resulted in lower risks of the primary end point (nonfatal myocardial infarction, nonfatal stroke, or death from cardiovascular causes) and death. However, the long-term effects of liraglutide on renal outcomes in patients with type 2 diabetes are unknown. METHODS: We report the prespecified secondary renal outcomes of that randomized, controlled trial in which patients were assigned to receive liraglutide or placebo. The secondary renal outcome was a composite of new-onset persistent macroalbuminuria, persistent doubling of the serum creatinine level, end-stage renal disease, or death due to renal disease. The risk of renal outcomes was determined with the use of time-to-event analyses with an intention-to-treat approach. Changes in the estimated glomerular filtration rate and albuminuria were also analyzed. RESULTS: A total of 9340 patients underwent randomization, and the median follow-up of the patients was 3.84 years. The renal outcome occurred in fewer participants in the liraglutide group than in the placebo group (268 of 4668 patients vs. 337 of 4672; hazard ratio, 0.78; 95% confidence interval [CI], 0.67 to 0.92; P=0.003). This result was driven primarily by the new onset of persistent macroalbuminuria, which occurred in fewer participants in the liraglutide group than in the placebo group (161 vs. 215 patients; hazard ratio, 0.74; 95% CI, 0.60 to 0.91; P=0.004). The rates of renal adverse events were similar in the liraglutide group and the placebo group (15.1 events and 16.5 events per 1000 patient-years), including the rate of acute kidney injury (7.1 and 6.2 events per 1000 patient-years, respectively). CONCLUSIONS: This prespecified secondary analysis shows that, when added to usual care, liraglutide resulted in lower rates of the development and progression of diabetic kidney disease than placebo. (Funded by Novo Nordisk and the National Institutes of Health; LEADER ClinicalTrials.gov number, NCT01179048 .).
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- 2017
11. Rosiglitazone-associated pseudotumour cerebri
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Dagdelen, S. and Gedik, O.
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- 2006
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12. Severe hyperglycemia associated with electroconvulsive therapy
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Dagdelen, S., Akin-Atmaca, A., Gürlek, A., Tufan, A., Güven, E., and Anil-Yagcioglu, E.
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- 2004
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13. Pituitary Corticotroph Microadenomas Versus Macroadenomas Causing Cushings Disease
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Aydin, K., Dagdelen, S., Burce OZGEN, Oruckaptan, H., Soylemezoglu, F., and Erbas, T.
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lcsh:RC648-665 ,kortikotropes Mikroadenom ,Morbus Cushing ,corticotroph microadenoma ,Cushings disease ,Sinus-cavernosus-Invasion ,cavernous sinus invasion ,corticotroph macroadenoma ,lcsh:Diseases of the endocrine glands. Clinical endocrinology ,kortikotropes Makroadenom - Abstract
Kortikotrope Hypophysen-Makroadenome vs. Mikroadenome als Ursache des Morbus Cushing. Ziel: Kortikotrope Hypophysen- Makroadenome werden für eine geringe Zahl von Fällen des Cushing-Syndroms verantwortlich gemacht, man geht jedoch davon aus, dass ihre genaue Prävalenz unterschätzt wird. Des Weiteren fallen die klinischen und biochemischen Manifestationen kortikotroper Makro- und Mikroadenome sehr unterschiedlich aus und in bisherigen Studien wurde nur eine geringe Anzahl von Patienten eingeschlossen. In dieser Arbeit analysieren und vergleichen wir die klinischen Charakteristika und biochemischen Eigenschaften von Patienten mit kortikotropen Makro- und Mikroadenomen, die Morbus Cushing verursachen. Methoden: Wir schlossen 107 Patienten mit M. Cushing ein (67 Mikroadenome, 40 Makroadenome). Klinische Charakteristika, biochemische Analysen des Hyperkortisolismus, Ergebnisse des Hypophysen-Imaging, Behandlungsmodalitäten sowie Raten für Remission und Wiederauftreten wurden erfasst. Ergebnisse: Das Durchschnittsalter der Patienten lag bei 46,5 ± 11,4 Jahren für Makroadenome und 37,3 ± 12,1 Jahre für Mikroadenome (p 0,001). Die Geschlechterverteilung war bei den Makroadenompatienten gleich, während bei den Mikroadenompatienten ein Vorherrschen der Frauen offensichtlich war (p = 0,001). Verglichen mit den Makro- war die klinische Evidenz des Hyperkortisolismus bei den Mikroadenomen stärker ausgeprägt. Obwohl die Präsentation der klinischen Manifestationen unterschiedlich war, waren die biochemische Analyse des Hyperkortisolismus (inklusive Basalkortisol, ACTH, 24-Stunden-Harnkortisol-Levels) und Ansprechen auf eine niedrig dosierte Dexamethason-Suppression zwischen den Gruppen ähnlich. Die Unterdrückbarkeit des Serumkortisols nach Gabe von hochdosiertem Dexamethason war für Makroadenome niedriger, erreichte aber keine Signifikanz (p = 0,074). Die Remissionsraten nach dem ersten hypophysenchirurgischen Eingriff (67,5 vs. 82,8 %) sowie die Rezidivraten bei Patienten, die länger als 6 Monate nachverfolgt wurden, waren bei beiden Gruppen vergleichbar. Ein Einwachsen in den Sinus cavernosus war ein negativer Prädiktor für Remission. Schlussfolgerung: Patienten mit kortikotropen Makro- und Mikroadenomen haben ähnliche laborchemische Veränderungen sowie Remissions- und Rezidivraten. Unterschiede gibt es jedoch bei der klinischen Präsentation. Ein Einwachsen des Tumors in den Sinus cavernosus ist ein negativer Prädikator für Remission.
- Published
- 2014
14. Chronotropic index, heart rate and exercise capacity in diabetes mellitus: comparing two different high-intensity interval training protocols
- Author
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Bozdemir Ozel, C, Arikan, H, Calik Kutukcu, E, Durukan, B N, Inal Ince, D, Kabakci, G, and Dagdelen, S
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- 2024
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15. The relationship between cardiovascular risk factors and cardiovascular fitness and physical activity in patients with T2DM and prediabetes
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Calik Kutukcu, E, Durukan, B N, Bozdemir Ozel, C, Arikan, H, and Dagdelen, S
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- 2024
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16. Ultrastructural Changes of Left Atrial Endomyocardium in Patients with Mitral Paraphosthetic Regurgitation
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YAYMACI, B., Bozbuga, N.U, Ercan, F., Dagdelen, S., Mansuroglu, D., Tuncer, A., and Erentug, V.
- Published
- 2015
17. Genetic Alterations in Differentiated Thyroid Cancer Patients with Acromegaly
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Aydin, K., additional, Aydin, C., additional, Dagdelen, S., additional, Tezel, G., additional, and Erbas, T., additional
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- 2015
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18. The Long Term Incidence and Predictors of Radial Artery Occlusion Following a Transradial Coronary Procedure
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Buturak, A., primary, Gorgulu, S., additional, Norgaz, T., additional, Voyvoda, N., additional, Sahingoz, Y., additional, Degirmencioglu, A., additional, Demirci, Y., additional, and Dagdelen, S., additional
- Published
- 2013
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19. Volatile Composition, Antioxidant and Antimicrobial Activities of Herbal Plants Used in the Manufacture of Van Herby (OTLU) Cheese
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Dagdelen, S., primary, Bilenler, T., additional, Durmaz, G., additional, Gokbulut, I., additional, Hayaloglu, A.A., additional, and Karabulut, I., additional
- Published
- 2013
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20. OP-009: ONE YEAR CLINICAL OUTCOMES OF PATIENTS WITH OVERLAPPED DRUG ELUTING STENTS
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Danzi, G., primary, Tastan, A., additional, Ates, I., additional, Dagdelen, S., additional, Chevalier, B., additional, Urban, P., additional, Wijns, W., additional, Wiemer, M., additional, Goicolea, J., additional, and Serra, A., additional
- Published
- 2011
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21. OP-008: LEFT MAIN DISEASE TREATED WITH PERCUTANEOUS CORONARY INTERVENTION: OUTCOMES WITH A THIRD GENERATION DES
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Danzi, G., primary, Tastan, A., additional, Ates, I., additional, Dagdelen, S., additional, Serra, A., additional, Marzocchi, A., additional, Stabile, A., additional, Wijns, W., additional, Laanmets, P., additional, and Brunel, P., additional
- Published
- 2011
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22. Endovascular Stent-graft Treatment of Type A Dissection: Case Report and Review of Literature
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Senay, S., Alhan, C., Toraman, F., Karabulut, H., Dagdelen, S., and Cagil, H.
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- 2007
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23. Genetic Alterations in Differentiated Thyroid Cancer Patients with Acromegaly.
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Aydin, K., Aydin, C., Dagdelen, S., Tezel, G. G., and Erbas, T.
- Subjects
THYROID cancer ,CANCER ,HYPERTROPHY ,PATHOLOGY ,TUMORS - Abstract
Aim: Acromegaly is associated with increased thyroid cancer risk. We aimed to analyze the frequency of point mutations of BRAF and RAS genes, and RET/PTC, PAX8/PPARγ gene rearrangements in patients with acromegaly having differentiated thyroid cancers (DTC) and their relation with clinical and histological features. Materials and Methods: 14 acromegalic patients (8 male, 6 female) with DTC were included. BRAF V600E and NRAS codon 61 point mutations, RET/PTC1, RET/PTC3, and PAX8/PPARγ gene rearrangements were analyzed in thyroidectomy specimens. We selected 14 non-acromegalic patients with DTC as a control group. Results: 2 patients (14.3%) were detected to have positive BRAF V600E and 3 patients (21.4%) were detected to have NRAS codon 61 mutation. NRAS codon 61 was the most frequent genetic alteration. Patients with positive mutation had aggressive histologic features more frequently than patients without mutations. Comparison of the acromegalic and non-acromegalic patients with DTC revealed that BRAF V600E mutation was more frequent in non-acromegalic patients with DTC (14.2% vs. 64.3%, p = 0.02). RET/PTC 1/3, PAX8/PPARγ gene rearrangements were not detected in any patient. None of the patients including the patients with positive point mutations had recurrence, and local and/or distant metastasis. Conclusion: NRAS codon 61 is the most frequent genetic alteration in this acromegaly series with DTC. Since acromegalic patients have lower prevalance of BRAF V600E mutation, BRAF V600E mutation may not be a causative factor in development of DTC in acromegaly. Despite the relation of BRAF V600E and NRAS codon 61 mutations with aggresive histopathologic features, their impact on tumor prognosis remains to be defined in acromegaly in further studies. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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24. Follow-Up of Pregnancy in Acromegalic Women: Different Presentations and Outcomes
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Atmaca, A., primary, Dagdelen, S., additional, and Erbas, T., additional
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- 2006
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25. Rosiglitazone-associated pseudotumour cerebri
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Dagdelen, S., primary and Gedik, O., additional
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- 2005
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26. Isolated halo sign in the middle of the left atrium
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DAGDELEN, S., primary
- Published
- 2001
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27. Volatile Composition, Antioxidant and Antimicrobial Activities of Herbal Plants Used in the Manufacture of Van Herby ( OTLU) Cheese.
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Dagdelen, S., Bilenler, T., Durmaz, G., Gokbulut, I., Hayaloglu, A.A., and Karabulut, I.
- Subjects
- *
HERBS , *ANTIOXIDANTS , *ANTI-infective agents , *VOLATILE organic compounds , *CHEESE , *CHIVE , *GAS chromatography , *MASS spectrometry - Abstract
The aim of this study was to investigate the antioxidative, antimicrobial and aroma characteristics of the most popular herbs, with local, namely Sirmo ( Allium schoenoprasum [ Liliaceae]), Mendi ( Chaerophyllum macropodum [ Apiaceae]), Siyabo ( Silene vulgaris [ Caryophyllaceae]), Yarpuz ( Mentha spicata [ Lamiaceae]) and Heliz ( Prangos ferulacea [ Apiaceae]). Among the various solvent extracts, methanolic extract of the Heliz, which had the highest phenolic content showed the highest 1,1-diphenyl-2-picrylhydrazyl ( DPPH) and 2,2′-azinobis-(3-ethylbenzthiazoline-6-sulfonate) ( ABTS) radical-scavenging activities. The antimicrobial activity of the plant extracts was also assessed. It was observed that growth of gram-positive bacteria was inhibited effectively by the extracts. Aroma compounds of the herbs were analyzed by headspace solid-phase microextraction-gas chromatography-mass spectrometry technique. The terpenes were the most representative chemical classes of the volatiles in herbs. Practical Application Traditionally, some herbs are used to enhance aromatic properties of cheeses in eastern region of Turkey. In the present study, some important properties of the most popular herbs used in cheese making were investigated. Methanol proved to be the most efficient solvent for extraction of antioxidants from herbs. The herbs could enhance the total antioxidant potential of cheese. The main outcome would be to exploit these findings at industrial scale to encourage the manufacture of herbal cheese. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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28. Metabolik sendrom tani kriterleri hakkinda yaşanan küresel kargaşa: kilavuzlarin anlaşamadiği nokta nedir?
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Dagdelen S, Yildirim T, Erbas T, Dağdelen, Selçuk, Yildirim, Tolga, and Erbaş, Tomris
- Abstract
Several international and national associations have proposed their own diagnostic criteria for metabolic syndrome. Regarding the heterogeneity of these guidelines, some authors refused the usage of metabolic syndrome definition. Here we aimed to analyze the differences between the diagnostic criteria proposed for metabolic syndrome. We reviewed and compared these different guidelines' criteria. We conclude that, despite the heterogeneity, there is a conceptual agreement on the definition of metabolic syndrome. But cut-off values and selection of diagnostic parameters are still conflicting. Diagnostic or definitive components of the syndrome (i.e., obesity, insulin resistance) should be considered separately from the associated-conditions (i.e., polycystic ovary, obstructive sleep apnea, microalbuminuria, non-alcoholic steatohepatitis etc.) of metabolic syndrome, during the course of diagnosis. Maintenance of the metabolic syndrome as a diagnostic category would still seem to be useful for an effective multiple cardiovascular risk prediction. [ABSTRACT FROM AUTHOR]
- Published
- 2008
29. Influence of type 2 diabetes mellitus on bone mineral density response to bisphosphonates in late postmenopausal osteoporosis.
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Dagdelen S, Sener D, Bayraktar M, Dagdelen, Selcuk, Sener, Didem, and Bayraktar, Miyase
- Abstract
Bisphosphonates are effective agents for postmenopausal osteoporosis, but their efficacy in patients with type 2 diabetes mellitus (DM) is not known. The investigators evaluated bone mineral density (BMD) response to alendronate in women with concurrent late postmenopausal osteoporosis and type 2 DM. In a retrospective, matched case-control study, 26 late postmenopausal osteoporotic women with type 2 DM (age, 67.6+/-7.3 y; type 2 DM duration, 12.8+/-6.8 y; duration of menopause, 10.9+/-7.4 y; time on alendronate: 4.8+/-2.3 y; body mass index [BMI], 31.4+/-6.3 kg/m2) were matched with 26 controls according to age, BMI, duration of menopause, and alendronate treatment received. All subjects were given alendronate 10 mg/d or 70 mg/wk, along with sufficient vitamin D (>or=400 IU) and calcium (>or=1 g/d) intake, for 4.8 y. Response to alendronate therapy was determined by assessment of mean percent change in BMD of total hip, femoral neck, forearm, and lateral spine. The presence of type 2 DM resulted in no difference in spinal BMD response to alendronate therapy. In contrast, BMD in the total hip (mean percent change in BMD, -5.6% vs +1.4%; P=.096), femoral neck (-8.1% vs +1.1%; P=.015), and forearm (-3.6% vs +12.7%; P=.013) fell progressively from baseline in subjects with type 2 DM who were taking alendronate for 4.8 y, compared with controls. Elderly, postmenopausal, osteoporotic obese women with type 2 DM are resistant to long-term bisphosphonates, especially in regions of the hip, femoral neck, and forearm compared with the spine. The efficacy of bone resorption inhibitors in patients with type 2 DM, especially in comparison with anabolic agents, should be considered in additional studies. [ABSTRACT FROM AUTHOR]
- Published
- 2007
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30. Punctate palmoplantar keratoderma (Brauer-Buschke-Fischer syndrome)
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Oztas P, Alli N, Polat M, Dagdelen S, Ustün H, Artüz F, and Erdemli E
- Published
- 2007
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31. Hyperprolactinemia of Pregnancy is Not Associated with Increased In Vivo Platelet Activity and Shortened In Vitro Bleeding Times.
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Atmaca, A., Gurlek, A., Dagdelen, S., Erarslan, N., Buyukasik, Y., Gultekin, M., Karamursel, B. S., and Onderoglu, L.
- Published
- 2006
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32. The response of the myocardial metabolism to atrial pacing in patients with coronary slow flow
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Yaymaci, B., Dagdelen, S., Bozbuga, N., Demirkol, O., Say, B., Guzelmeric, F., and Dindar, I.
- Published
- 2001
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33. MON-113 Taste Sensitivity is Related to Incretin Response to Oral Glucose Challenge, Dietary Habits and Body Composition: A Novel Link with Energy Metabolism
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Dagdelen S, Avci S, Solakoglu T, Cem Simsek, Firlatan B, Lay I, Unluturk U, Acikgoz A, and Erbas T
34. Acute left main coronary artery occlusion following TAVI and emergency solution.
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Dagdelen S, Karabulut H, and Alhan C
- Published
- 2011
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35. Addition of insulin to oral therapy in type 2 diabetes.
- Author
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Dagdelen S
- Published
- 2008
36. Pituitary hypoplasia and growth hormone deficiency in a woman with glycogen storage disease type Ia: a case report
- Author
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Dagdelen Selcuk, Atmaca Aysegul, Alikasifoglu Ayfer, and Erbas Tomris
- Subjects
Medicine - Abstract
Abstract Introduction Growth retardation is one of the cardinal manifestations of glycogen storage disease type Ia. It is unclear which component of the growth hormone and/or insulin-like growth factor axis is primarily disrupted, and management of growth impairment in these patients remains controversial. Here we report the first case in the literature where glycogen storage disease type Ia is associated with pituitary hypoplasia and growth hormone deficiency. Case presentation A 20-year-old woman with glycogen storage disease type Ia was admitted to our endocrinology department because of growth retardation. Basal and overnight growth hormone sampling at 2-hour intervals demonstrated low levels; however, provocative testing revealed a relatively normal growth hormone response. A hypoplastic anterior pituitary with preserved growth hormone response to provocative testing suggested the possibility of growth hormone neurosecretory dysfunction and/or primary pituitary involvement. Conclusion Pituitary hypoplasia may result from growth hormone-releasing hormone deficiency, a condition generally known as growth hormone neurosecretory dysfunction. It is an abnormality with a spontaneous and pulsatile secretion pattern, characterized by short stature, growth retardation and normal serum growth hormone response to provocative testing. However, in the case described in this report, a normal although relatively low growth hormone response during insulin tolerance testing and pituitary hypoplasia suggested that primary pituitary involvement or growth hormone neurosecretory dysfunction may occur in glycogen storage disease type Ia. This is a potential cause of growth failure associated with a lower somatotroph mass, and may explain the variable responsiveness to growth hormone replacement therapy in people with glycogen storage disease.
- Published
- 2008
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37. Interventional therapy in resistant hypertension; new renal denervation applications in Turkey].
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Dagdelen S and Batur MK
- Published
- 2012
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38. Evaluation of the relation between subclinical systolic dysfunction defined by four-dimensional speckle-tracking echocardiography and growth differentiation factor-15 levels in patients with acromegaly.
- Author
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Firlatan B, Karakulak UN, Hekimsoy V, Iremli BG, Lay I, Yuce D, Dagdelen S, Kabakci G, and Erbas T
- Subjects
- Humans, Male, Female, Middle Aged, Cross-Sectional Studies, Adult, Case-Control Studies, Acromegaly blood, Acromegaly diagnostic imaging, Acromegaly physiopathology, Growth Differentiation Factor 15 blood, Echocardiography methods
- Abstract
Purpose: In patients with acromegaly, the long-term presence of elevated GH and IGF-1 levels is associated with an unfavorable cardiovascular risk profile. We aimed to assess the relationship of four-dimensional speckle tracking echocardiographic (4DSTE) measurements with growth differentiation factor-15 (GDF-15) levels and the Framingham Cardiovascular Risk Score (FRS) in patients with acromegaly., Methods: A single-center, cross-sectional study was conducted. The study included 40 acromegaly and 32 age- and gender-matched controls. Anthropometric, biochemical, and echocardiographic assessments were performed. GDF-15 levels were measured using ELISA., Results: In the controlled acromegaly group, global longitudinal (GLS), circumferential (GCS), area (GAS), and radial (GRS) strain measurements identified by 4DSTE were lower than those of the controls (p < 0.05). Moreover, strain parameters were lower in active acromegaly patients than in controls, but the difference was not statistically significant. The GLS was negatively correlated with age, the estimated disease duration, and FRS. Serum GDF-15 levels showed no significant difference between the acromegaly and control groups. In patients with acromegaly, serum GDF-15 levels were positively correlated with age, waist-to-hip ratio, systolic and diastolic blood pressure, FRS, fasting plasma glucose, and HbA1c, but not with strain parameters. The multiple regression analysis revealed that FRS was an independent factor associated with serum GDF-15 levels in patients with acromegaly and the overall cohort (p < 0.001)., Conclusion: Our study demonstrates that while LVEF was within normal limits, global strain parameters (GLS, GCS, GAS, and GRS) measured by using a novel imaging technique, 4DSTE, were lower in patients with acromegaly, suggesting the presence of subclinical systolic dysfunction in patients with acromegaly. GDF-15 can be a potential predictor of cardiovascular risk in patients with acromegaly., (© 2024. The Author(s), under exclusive licence to Hellenic Endocrine Society.)
- Published
- 2024
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39. Rapid Photoinduced Self-Healing, Controllable Drug Release, Skin Adhesion Ability, and Mechanical Stability of Hydrogels Incorporating Linker-Modified Gold Nanoparticles and Nanogels.
- Author
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Khodami S, Gharakhloo M, Dagdelen S, Fita P, Romanski J, Karbarz M, Stojek Z, and Mackiewicz M
- Subjects
- Acrylic Resins chemistry, Skin, Animals, Polyethylene Glycols chemistry, Adhesiveness, Gold chemistry, Hydrogels chemistry, Metal Nanoparticles chemistry, Drug Liberation, Nanogels chemistry
- Abstract
Appropriately modified thermoresponsive hydrogels, such as poly( N -isopropylacrylamide) hydrogels, bring an opportunity for a variety of biomedical applications. Incorporating compounds with different properties into poly( N -isopropylacrylamide) hydrogels offers opportunities to enhance their mechanical, self-healing ability, adhesiveness, thermal responsiveness, and drug release capabilities. In this study, we investigated the influence of Au-sulfur interactions on the properties of the poly( N -isopropylacrylamide) hydrogels after introducing N,N' -bis(acryloyl)cystine (a newly synthesized cross-linker), modified gold nanoparticles, and a p(NIPAm-BISS) nanogel into the hydrogel matrix. Our findings demonstrated that poly( N -isopropylacrylamide) hydrogels with these compounds exhibited higher mechanical strength (65% tensile stress and 25% elongation), faster thermal responsiveness, controllable self-healing [85% recovery after 2 min, using a NIR laser (800 nm, 0.75 W)], skin adhesiveness, and enhanced drug release (0.08 mg·mL
-1 , a 93% improvement). These results may contribute to advancements in the design of temperature-responsive hydrogels tailored for specific biomedical needs, such as targeted drug delivery with the use of a NIR laser and tissue engineering.- Published
- 2024
- Full Text
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40. Follow, consider, and catch: second primary tumors in acromegaly patients.
- Author
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Oguz SH, Firlatan B, Sendur SN, Dagdelen S, and Erbas T
- Subjects
- Humans, Retrospective Studies, Delayed Diagnosis adverse effects, Insulin-Like Growth Factor I, Acromegaly complications, Acromegaly epidemiology, Acromegaly diagnosis, Thyroid Neoplasms complications, Thyroid Neoplasms epidemiology, Thyroid Neoplasms diagnosis, Neoplasms, Second Primary epidemiology, Neoplasms, Second Primary complications, Human Growth Hormone
- Abstract
Background and Aim: The risk of second primary tumors is increased in general cancer population, however, there is no data on acromegalic cancer patients in this regard. The aim of this study is to determine the prevalence of patients with two primary tumors among acromegalic cancer patients and to evaluate if patients with two primaries have distinct clinical characteristics or risk factors compared to those with one., Methods: This is a single-center retrospective cohort study. The study included 63 patients with at least one malignant tumor out of a total number of 394 acromegaly patients. Patients with multiple primary neoplasms were evaluated in detail., Results: This study revealed a 16% cancer prevalence in acromegaly patients, with 14% (9/63) having two primary neoplasms. Papillary thyroid carcinoma was the most prevalent tumor in the entire cancer cohort (41%, 26/63), and in the group of patients with two primaries (44%, 4/9). Patients with two primary tumors were older than those with one when diagnosed with acromegaly (48.3 ± 16.6 vs. 43.3 ± 10.7 years), which might be attributed to a longer diagnostic delay (median of 4.5 vs. 2 years). The period between the onset of acromegaly symptoms and diagnosis was not associated with earlier cancer diagnosis. No relationship between circulating GH or IGF-I levels and the number of neoplasms was found., Conclusion: The development of second primary tumors in acromegalic patients with cancer diagnosis is not rare. Acromegalic cancer patients should be closely monitored for new symptoms or signs that could be associated with second primary tumors., (© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
- Published
- 2023
- Full Text
- View/download PDF
41. Giant growth hormone-secreting pituitary adenomas from the endocrinologist's perspective.
- Author
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Koylu B, Firlatan B, Sendur SN, Oguz SH, Dagdelen S, and Erbas T
- Subjects
- Humans, Male, Female, Insulin-Like Growth Factor I, Endocrinologists, Treatment Outcome, Retrospective Studies, Growth Hormone-Secreting Pituitary Adenoma surgery, Growth Hormone-Secreting Pituitary Adenoma pathology, Acromegaly etiology, Acromegaly surgery, Adenoma diagnostic imaging, Adenoma surgery, Adenoma pathology, Pituitary Neoplasms surgery, Pituitary Neoplasms pathology, Human Growth Hormone
- Abstract
Objectives: Since giant (≥40 mm) GH-secreting pituitary adenomas are rarely encountered, data on their characteristics and treatment outcomes are limited. We aimed to investigate the characteristics of giant GH-secreting pituitary adenomas and to compare their clinical, biochemical, imaging and histopathological features with non-giant macroadenomas., Materials and Methods: We have evaluated 15 (six female/nine male) and 57 (29 female/28 male) patients with acromegaly in giant and <40 mm adenoma groups, respectively. Patients with <40 mm adenoma were further divided into subgroups with adenoma size 20-29 mm and 30-39 mm., Results: In giant adenoma group, median (IQR) preoperative maximal diameter of adenoma was 40 mm (5 mm), median preoperative GH level was 40 (153.4) ng/mL and median baseline IGF-1 level was 2.19 (1.88) × ULN for age and sex. The number of surgeries was significantly higher in giant adenoma group (median 2, IQR 2) in which 66.7% of patients underwent repeated surgeries (p = 0.014). Residual tumor was detected after last operation in all patients with giant adenoma. Total number of treatment modalities administered postoperatively increased as adenoma size increased (p = 0.043). After a median follow-up duration of 10 years (IQR 10), hormonal remission was achieved in six patients (40%) of giant adenoma group, while the rate of hormonal remission in non-giant adenoma group was 37%. Although preoperative GH and IGF-1 levels and Ki-67 index tended to be higher with increasing adenoma size, there was no statistically significant difference between groups in terms of these variables, as well as age, sex and invasion status., Conclusion: Hormonal remission rates of acromegaly patients with ≥20 mm pituitary macroadenoma were comparable. However, giant GH-secreting pituitary adenomas require an aggressive multimodal treatment approach., (© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
- Published
- 2023
- Full Text
- View/download PDF
42. The Clinical Characteristics and Outcomes of COVID-19 Patients with Pre-Existing Thyroid Dysfunction: A Nationwide Study.
- Author
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Sahin M, Demirci I, Haymana C, Tasci I, Emral R, Cakal E, Unluturk U, Satman I, Demir T, Ata N, Ertugrul D, Atmaca A, Salman S, Sahin I, Dagdelen S, Celik O, Caglayan M, and Sonmez A
- Subjects
- Humans, Male, Retrospective Studies, COVID-19 complications, Thyroid Diseases, Hypothyroidism complications, Hypothyroidism epidemiology, Hyperthyroidism complications, Hyperthyroidism epidemiology
- Abstract
To which extent the pre-existing hypothyroidism or hyperthyroidism has an impact on coronavirus infection 2019 (COVID-19) outcomes remains unclear. The objective of this study was to evaluate COVID-19 morbidity and mortality in patients with pre-existing thyroid dysfunction. A retrospective cohort of patients with a polymerase chain reaction (PCR)-confirmed COVID-19 infection (n=14 966) from March 11 to May 30, 2020, was established using the database of the Turkish Ministry of Health. We compared the morbidity and mortality rates of COVID-19 patients with pre-existing hypothyroidism (n=8813) and hyperthyroidism (n=1822) to those patients with normal thyroid function (n=4331). Univariate and multivariate regression analyses were performed to identify the factors associated with mortality. Mortality rates were higher in patients with hyperthyroidism (7.7%) and hypothyroidism (4.4%) than those with normal thyroid function (3.4%) (p<0.001 and p=0.008, respectively). Pre-existing hyperthyroidism was significantly associated with an increased risk of mortality (OR 1.54; 95% CI, 1.02-2.33; p=0.042) along with advanced age, male gender, lymphopenia and chronic kidney disease (p<0.001 for all). Although a potential trend was noted, the association between pre-existing hypothyroidism and mortality was not significant (OR 1.36; 95% CI, 0.99-1.86; p=0.055). In conclusion, this study showed an association between pre-existing hyperthyroidism with higher COVID-19 mortality. A potential trend towards increased mortality was also observed for hypothyroidism. The risk was more pronounced in patients with hyperthyroidism., Competing Interests: The authors declare that they have no conflict of interest., (Thieme. All rights reserved.)
- Published
- 2023
- Full Text
- View/download PDF
43. Energy expenditure and glucose-lowering effect of different exercise modalities in diabetes mellitus.
- Author
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Bozdemir-Ozel C, Arikan H, Çalik-Kutukcu E, Karaduz BN, Inal-Ince D, Kabakci G, and Dagdelen S
- Subjects
- Male, Humans, Female, Middle Aged, Cross-Sectional Studies, Exercise Test methods, Energy Metabolism, Glucose, Diabetes Mellitus, Type 2, Hypoglycemia
- Abstract
Objectives: Hypoglycaemia is a serious complication of exercise in patients with type 2 diabetes mellitus (T2DM). The aim of this study was to test energy expenditure and the degree of the glucose-lowering effect of different exercise modalities., Design: Cross-sectional study PARTICIPANTS: This study included 44 patients {35 women and nine men, mean age 51 [standard deviation (SD) 5] years} with T2DM [mean HbA1c 7% (SD 1%)]., Main Outcome Measures: Standardised exercise tests for walking, running and cycling were performed using the 6-minute walk test (6MWT), incremental shuttle walk test (ISWT), and symptom-limited maximal cycle exercise test, respectively. Energy expenditure was assessed with a multisensory accelerometer. Change in capillary glucose levels (∆glucose) was measured before and after each exercise modality., Results: ∆Glucose was lower in the 6MWT {median 14 [interquartile range (IQR) 22] mg/dl} than in the ISWT [median 18 (IQR 23) mg/dl; median difference 7 mg/dl, 95% confidence interval (CI) of the difference 3-11] and the cycle test [median 18 (IQR 24) mg/dl; median difference 7 mg/dl, 95% CI 0-16]. Energy expenditure was lower during the 6MWT [median 41 (IQR 18) Kcal] compared with the ISWT [median 51 (IQR 23) Kcal; median difference 11 Kcal, 95% CI 6-16] and the cycle test [median 44 (IQR 25) Kcal; median difference 6 Kcal, 95% CI 0-13]., Conclusions: Energy expenditure and corresponding glucose-lowering effect during exercise in patients with T2DM can be predicted from the results of an exercise test. The type of exercise is related to the risk of hypoglycaemia. Walking is associated with the lowest energy expenditure and risk of hypoglycaemia, while cycling and running/jogging cause higher energy expenditure and greater reductions in glucose in patients with T2DM. CONTRIBUTION OF THE PAPER., Competing Interests: Conflict of interests None declared., (Copyright © 2022 Chartered Society of Physiotherapy. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2022
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44. Reduced irisin levels in patients with acromegaly.
- Author
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Sendur SN, Baykal G, Firlatan B, Aydin B, Lay I, Dagdelen S, Alikasifoglu M, and Erbas T
- Subjects
- Adult, Case-Control Studies, Cross-Sectional Studies, Fibronectins, Growth Hormone, Humans, Insulin-Like Growth Factor I analysis, Ligands, Middle Aged, Receptors, Somatostatin, Somatostatin, Acromegaly genetics
- Abstract
Objectives: Several metabolic disturbances are seen in acromegaly however, data regarding the contribution of irisin to these disturbances is currently insufficient. In a cohort of patients with acromegaly, we measured serum irisin levels in active and controlled cases and determined independent factors that effect serum irisin including fibronectin type III domain-containing protein 5 (FNDC5) genotyping., Methods: A cross-sectional case-control study including 46 patients with acromegaly (28 F/18 M, age: 50.3 ± 12.1 year, BMI: 30.7 ± 5.1 kg/m
2 ) and 81 age-, gender-, body mass index- and body composition-matched healthy controls was conducted. 15 acromegalic patients (33%) had active disease. Irisin levels were measured by enzyme-linked immunosorbent assay. Three different regions (rs3480, rs1746661, and rs16835198) of FNDC5 were subjected to polymorphism analyses., Results: Both groups were overweight and had similar body composition. Irisin levels were lower in patients with acromegaly than controls (median [IQR]: 44.8 [41.7-46.7] ng/mL vs. 51.7 [45.5-60.1] ng/mL, p≤0.001, respectively). Active and controlled patients had similar irisin levels. Irisin was not correlated with growth hormone (GH), insulin-like growth factor 1 (IGF-1), and IGF-1 index. In multiple linear regression model, somatostatin receptor ligand use ( β =-20.30, 95% CI [-34]-[-6], p=0.006) was determined as the only independent factor that affect serum irisin., Conclusions: Serum irisin levels are low in patients with acromegaly who are on somatostatin receptor ligand therapy. Single nucleotide polymorphisms (SNPs) of FNDC5 have no independent effects on circulating irisin levels under somatostatin ligand action. Endocrine muscle functions also seem to be regulated by somatostatin action, which requires further studies., (© 2022 Walter de Gruyter GmbH, Berlin/Boston.)- Published
- 2022
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45. Discrimination between non-functioning pituitary adenomas and hypophysitis using machine learning methods based on magnetic resonance imaging‑derived texture features.
- Author
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Sahin S, Yildiz G, Oguz SH, Civan O, Cicek E, Durcan E, Comunoglu N, Ozkaya HM, Oz AB, Soylemezoglu F, Oguz KK, Dagdelen S, Erbas T, Kizilkilic O, and Kadioglu P
- Subjects
- Humans, Machine Learning, Magnetic Resonance Imaging methods, Retrospective Studies, Hypophysitis, Pituitary Neoplasms diagnostic imaging, Pituitary Neoplasms pathology
- Abstract
Purpose: Hypophysitis is a heterogeneous condition that includes inflammation of the pituitary gland and infundibulum, and it can cause symptoms related to mass effects and hormonal deficiencies. We aimed to evaluate the potential role of machine learning methods in differentiating hypophysitis from non-functioning pituitary adenomas., Methods: The radiomic parameters obtained from T1A-C images were used. Among the radiomic parameters, parameters capable of distinguishing between hypophysitis and non-functioning pituitary adenomas were selected. In order to avoid the effects of confounding factors and to improve the performance of the classifiers, parameters with high correlation with each other were eliminated. Machine learning algorithms were performed with the combination of gray-level run-length matrix-low gray level run emphasis, gray-level co-occurrence matrix-correlation, and gray-level co-occurrence entropy., Results: A total of 34 patients were included, 17 of whom had hypophysitis and 17 had non-functioning pituitary adenomas. Among the 38 radiomics parameters obtained from post-contrast T1-weighted images, 10 tissue features that could differentiate the lesions were selected. Machine learning algorithms were performed using three selected parameters; gray level run length matrix-low gray level run emphasis, gray-level co-occurrence matrix-correlation, and gray level co-occurrence entropy. Error matrices were calculated by using the machine learning algorithm and it was seen that support vector machines showed the best performance in distinguishing the two lesion types., Conclusions: Our analysis reported that support vector machines showed the best performance in distinguishing hypophysitis from non-functioning pituitary adenomas, emphasizing the importance of machine learning in differentiating the two lesions., (© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
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- 2022
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46. No association of Gaucher disease with COVID-19-related outcomes: a nationwide cohort study.
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Demirci I, Demir T, Dagdelen S, Haymana C, Tasci I, Atmaca A, Ertugrul D, Ata N, Sahin M, Salman S, Sahin I, Emral R, Unluturk U, Cakal E, Celik O, Caglayan M, Satman I, and Sonmez A
- Subjects
- Cohort Studies, Hospitalization, Humans, Intensive Care Units, Pandemics, Retrospective Studies, SARS-CoV-2, COVID-19 epidemiology, Diabetes Mellitus, Type 2 epidemiology, Gaucher Disease complications, Gaucher Disease epidemiology
- Abstract
Background: It is well documented that patients with chronic metabolic diseases, such as diabetes and obesity, are adversely affected by the COVID-19 pandemic. However, when the subject is rare metabolic diseases, there are not enough data in the literature., Aim: To investigate the course of COVID-19 among patients with Gaucher disease (GD), the most common lysosomal storage disease., Methods: Based on the National Health System data, a retrospective cohort of patients with confirmed (polymerase chain reactionpositive) COVID-19 infection (n = 149 618) was investigated. The adverse outcomes between patients with GD (n = 39) and those without GD (n = 149 579) were compared with crude and propensity score-matched (PSM) groups. The outcomes were hospitalisation, the composite of intensive care unit (ICU) admission and/or mechanical ventilation and mortality., Results: The patients with GD were significantly older and had a higher frequency of hypertension (HT), Type 2 diabetes mellitus (T2DM), dyslipidaemia, asthma or chronic obstructive pulmonary disease, chronic kidney disease, coronary artery disease, heart failure and cancer. Although hospitalisation rates in Gaucher patients were found to be higher in crude analyses, the PSM models (model 1, age and gender matched; model 2, matched for age, gender, HT, T2DM and cancer) revealed no difference for the outcomes between patients with GD and the general population. According to multivariate regression analyses, having a diagnosis of GD was not a significant predictor for hospitalisation (P = 0.241), ICU admission/mechanical ventilation (P = 0.403) or mortality (P = 0.231)., Conclusion: According to our national data, SARS-CoV-2 infection in patients with GD does not have a more severe course than the normal population., (© 2021 Royal Australasian College of Physicians.)
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- 2022
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47. Clinical Characteristics and Outcomes of COVID-19 Patients with Overweight and Obesity: Turkish Nationwide Cohort Study (TurCObesity).
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Sahin I, Haymana C, Demir T, Demirci I, Tasci I, Atmaca A, Cakal E, Ata N, Emral R, Unluturk U, Ertugrul D, Salman S, Sahin M, Dagdelen S, Celik O, Caglayan M, Satman I, and Sonmez A
- Subjects
- Adolescent, Adult, COVID-19 therapy, Disease-Free Survival, Female, Humans, Male, Middle Aged, Obesity therapy, Retrospective Studies, Risk Factors, Survival Rate, Turkey epidemiology, COVID-19 mortality, Obesity mortality, SARS-CoV-2
- Abstract
Purpose: While obesity is related to more severe outcomes of coronavirus disease 2019 (COVID-19), factors leading to poor prognosis still remain unclear. The present study evaluated the outcomes of COVID-19 patients who were overweight or obese and variables associated with severe disease in a large group of consecutive cases., Methods: A nationwide retrospective cohort study was performed using the Turkish National Healthcare Database. Demographic characteristics, laboratory tests, comorbidities, and medications of patients registered between March 11 and May 30, 2020, were recorded., Results: A total of 14, 625 patients (median age:42, IQR:26 years; female 57.4%) with normal weight (34.7%), overweight (35.6%), and obesity (29.7%) were included. Hospitalization, ICU admission, intubation/mechanical ventilation, pulmonary involvement, and mortality were significantly higher in patients who were overweight or obese. In adjusted analyses, both overweight (OR, 95% CI: 1.82, 1.04-3.21; p=0.037) and obesity (OR, 95% CI: 2.69, 1.02-1.05; p<0.001) were associated with a higher intubation/mechanical ventilation rate but only obesity was associated with increased mortality (OR, 95% CI: 2.56, 1.40-4.67; p=0.002). Old age, male gender, chronic kidney disease, and high C reactive protein levels were independently associated with COVID-19 mortality in overweight or obese patients., Conclusions: COVID-19 patients who were overweight or obese were more likely to have adverse outcomes but only obesity was a predictor of mortality. Such patients should receive urgent medical attention and active management, especially the elderly, men, and people with chronic kidney disease., Competing Interests: The authors have no potential conflicts of interest to disclose., (Thieme. All rights reserved.)
- Published
- 2022
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48. Expert Panel Recommendations for Use of Standardized Glucose Reporting System Based on Standardized Glucometrics Plus Visual Ambulatory Glucose Profile (AGP) Data in Clinical Practice.
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Dagdelen S, Deyneli O, Dinccag N, Ilkova H, Osar Siva Z, Yetkin I, and Yilmaz T
- Subjects
- Diabetes Mellitus metabolism, Disease Management, Glycated Hemoglobin metabolism, Humans, Practice Guidelines as Topic, Blood Glucose metabolism, Blood Glucose Self-Monitoring methods, Diabetes Mellitus therapy, Monitoring, Ambulatory methods, Reference Standards
- Abstract
This expert panel of diabetes specialists aimed to provide guidance to healthcare providers on the best practice in the use of innovative continuous glucose monitoring (CGM) techniques through a practical and implementable document that specifically addresses the rationale for and also analysis and interpretation of the new standardized glucose reporting system based on standardized CGM metrics and visual ambulatory glucose profile (AGP) data. This guidance document presents recommendations and a useful algorithm for the use of a standardized glucose reporting system in the routine diabetes care setting., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Dagdelen, Deyneli, Dinccag, Ilkova, Osar Siva, Yetkin and Yilmaz.)
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- 2022
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49. Higher rate of COVID-19 mortality in patients with type 1 than type 2 diabetes: a nationwide study.
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Demirci I, Haymana C, Tasci I, Satman I, Atmaca A, Sahin M, Ata N, Unluturk U, Cakal E, Dagdelen S, Sahin I, Celik O, Ertugrul D, Demir T, Emral R, Caglayan M, Salman S, Birinci S, and Sonmez A
- Subjects
- Hospitalization, Humans, Retrospective Studies, COVID-19, Diabetes Mellitus, Type 1 complications, Diabetes Mellitus, Type 2 complications
- Abstract
Introduction: COVID-19 disease has a worse prognosis in patients with diabetes, but comparative data about the course of COVID-19 in patients with type 1 (T1DM) and type 2 diabetes (T2DM) are lacking. The purpose of this study was to find out the relative clinical severity and mortality of COVID-19 patients with T1DM and T2DM., Material and Methods: A nationwide retrospective cohort of patients with confirmed (PCR positive) COVID-19 infection (n = 149,671) was investigated. After exclusion of individuals with unspecified diabetes status, the adverse outcomes between patients with T1DM (n = 163), T2DM (n = 33,478) and those without diabetes (n = 115,108) were compared by using the propensity score matching method. The outcomes were hospitalization, the composite of intensive care unit (ICU) admission and/or mechanical ventilation, and mortality., Results: The patients with T1DM had higher mortality than the age- and gender-matched patients with T2DM (n = 489) and those without diabetes (n = 489) (p < 0.001). After further adjustment for the HbA1c, and microvascular and macrovascular complications, the odds of mortality (OR: 3.35, 95% CI: 1.41-7.96, p = 0.006) and ICU admission and/or mechanical ventilation (OR: 2.95, 95% CI: 1.28-6.77, p = 0.011) were significantly higher in patients with T1DM compared to those with T2DM. Older age (OR: 1.06, 95% CI: 1.01-1.12, p = 0.028) and lymphopaenia (OR: 5.13, 95% CI: 1.04-25.5, p = 0.045) were independently associated with mortality in patients with T1DM., Conclusions: Patients with T1DM had worse prognosis of COVID-19 compared to T2DM patients or those without diabetes. These cases should be cared for diligently until more data become available about the causes of increased COVID-19 mortality in T1DM.
- Published
- 2022
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50. 68Ga-DOTATATE PET/CT in Pituitary Carcinoma.
- Author
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Kaya G, Soydas Turan B, Dagdelen S, Berker M, and Tuncel M
- Subjects
- Female, Humans, Magnetic Resonance Imaging, Middle Aged, Positron Emission Tomography Computed Tomography, Adenoma, Organometallic Compounds, Pituitary Neoplasms diagnostic imaging
- Abstract
Abstract: A 47-year-old woman with atypical pituitary adenoma was referred to the neurosurgery department due to recent back pain. She had multiple transsphenoidal surgery, stereotactic body radiation, and 177Lu-DOTATATE therapy. Her spinal MRI showed multiple spinal masses. The patient underwent 68Ga-DOTATATE PET/CT to confirm the metastatic spread of the disease. PET/CT images showed increased uptake at the local recurrent tumor site and spinal metastases confirmed by biopsy to pituitary carcinoma. Our case presents the role of 68Ga-DOTATATE PET/CT in patients with pituitary carcinoma., Competing Interests: Conflicts of interest and sources of funding: none declared., (Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.)
- Published
- 2021
- Full Text
- View/download PDF
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