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The transport of particles through channels holds immense significance in physics, chemistry, and biological sciences. For instance, the motion of solutes through biological channels is facilitated by specialized proteins that create water-filled channels and valuable insights can be obtained by studying the transition paths of particles through a channel and gathering statistics on their lifetimes within the channel or their exit probabilities. In a similar vein, we consider a one-dimensional model of channel-facilitated transport where a diffusive particle is subject to attractive interactions with the walls within a limited region of the channel. We study the statistics of conditional and unconditional escape times, in the presence of resetting--an intermittent dynamics that brings the particle back to its initial coordinate randomly. We determine analytically the physical conditions under which such resetting mechanism can become beneficial for faster escape of the particles from the channel thus enhancing the transport. Our theory has been verified with the aid of Brownian dynamics simulations for various interaction strengths and extent. The overall results presented herein highlight the scope of resetting-based strategies to be universally promising for complex transport processes of single or long molecules through biological membranes., Comment: 20 pages, 9 sets of figures

We study the problem of a target search by a Brownian particle subject to stochastic resetting to a pair of sites. The mean search time is minimized by an optimal resetting rate which does not vary smoothly, in contrast with the well-known single site case, but exhibits a discontinuous transition as the position of one resetting site is varied while keeping the initial position of the particle fixed, or vice-versa. The discontinuity vanishes at a "liquid-gas" critical point in position space. This critical point exists provided that the relative weight $m$ of the further site is comprised in the interval $[2.9028...,8.5603...]$. When the initial position follows the resetting point distribution, a discontinuous transition also exists for the optimal rate as the distance between the resetting points is varied, provided that $m$ exceeds the critical value $m_c=6.6008...$ This setup can be mapped onto an intermittent search problem with switching diffusion coefficients and represents a minimal model for the study of distributed resetting., Comment: 7 pages, 6 Figures, typos corrected

Transport of particles through channels is of paramount importance in physics, chemistry and surface science due to its broad real world applications. Much insights can be gained by observing the transition paths of a particle through a channel and collecting statistics on the lifetimes in the channel or the escape probabilities from the channel. In this paper, we consider the diffusive transport through a narrow conical channel of a Brownian particle subject to intermittent dynamics, namely, stochastic resetting. As such, resetting brings the particle back to a desired location from where it resumes its diffusive phase. To this end, we extend the Fick-Jacobs theory of channel-facilitated diffusive transport to resetting-induced transport. Exact expressions for the conditional mean first passage times, escape probabilities and the total average lifetime in the channel are obtained, and their behaviour as a function of the resetting rate are highlighted. It is shown that resetting can expedite the transport through the channel -- rigorous constraints for such conditions are then illustrated. Furthermore, we observe that a carefully chosen resetting rate can render the average lifetime of the particle inside the channel minimal. Interestingly, the optimal rate undergoes continuous and discontinuous transitions as some relevant system parameters are varied. The validity of our one-dimensional analysis and the corresponding theoretical predictions are supported by three-dimensional Brownian dynamics simulations. We thus believe that resetting can be useful to facilitate particle transport across biological membranes -- a phenomena that can spearhead further theoretical and experimental studies.

Being motivated by recent progress in nanopore sensing, we develop a theory of the effect of large analytes, or blockers, trapped within the nanopore confines, on diffusion flow of small solutes. The focus is on the nanopore diffusion resistance which is the ratio of the solute concentration difference in the reservoirs connected by the nanopore to the solute flux driven by this difference. Analytical expressions for the diffusion resistance are derived for a cylindrically symmetric blocker whose axis coincides with the axis of a cylindrical nanopore in two limiting cases where the blocker radius changes either smoothly or abruptly. Comparison of our theoretical predictions with the results obtained from Brownian dynamics simulations shows good agreement between the two.

We study the crossing time statistic of diffusing point particles between the two ends of expanding and narrowing two-dimensional conical channels under a transverse external gravitational field. The theoretical expression for the mean first-passage time for such a system is derived under the assumption that the axial diffusion in a two-dimensional channel of smoothly varying geometry can be approximately described as a one-dimensional diffusion in an entropic potential with position-dependent effective diffusivity in terms of the modified Fick-Jacobs equation. We analyze the channel crossing dynamics in terms of the mean first-passage time, combining our analytical results with extensive two-dimensional Brownian dynamics simulations, allowing us to find the range of applicability of the one-dimensional approximation. We find that the effective particle diffusivity decreases with increasing amplitude of the external potential. Remarkably, the mean first-passage time for crossing the channel is shown to assume a minimum at finite values of the potential amplitude., Comment: 8 pages, 4 figures, RevTeX

Membrane protein transporters alternate their substrate-binding sites between the extracellular and cytosolic side of the membrane according to the alternating access mechanism. Inspired by this intriguing mechanism devised by nature, we study particle transport through a channel coupled with an energy well that oscillates its position between the two entrances of the channel. We optimize particle transport across the channel by adjusting the oscillation frequency. At the optimal oscillation frequency, the translocation rate through the channel is a hundred times higher with respect to free diffusion across the channel. Our findings reveal the effect of time dependent potentials on particle transport across a channel and will be relevant for membrane transport and microfluidics application.

We report fully relativistic molecular-dynamics simulations that verify the appearance of thermal equilibrium of a classical gas inside a uniformly accelerated container. The numerical experiments confirm that the local momentum distribution in this system is very well approximated by the J\"uttner function -- originally derived for a flat spacetime -- via the Tolman-Ehrenfest effect. Moreover, it is shown that when the acceleration or the container size is large enough, the global momentum distribution can be described by the so-called modified J\"uttner function, which was initially proposed as an alternative to the J\"uttner function.

Polymer quantum systems are mechanical models quantized similarly as loop quantum gravity. It is actually in quantizing gravity that the polymer term holds proper as the quantum geometry excitations yield a reminiscent of a polymer material. In such an approach both non-singular cosmological models and a microscopic basis for the entropy of some black holes have arisen. Also important physical questions for these systems involve thermodynamics. With this motivation, in this work, we study the statistical thermodynamics of two one dimensional {\em polymer} quantum systems: an ensemble of oscillators that describe a solid and a bunch of non-interacting particles in a box, which thus form an ideal gas. We first study the spectra of these polymer systems. It turns out useful for the analysis to consider the length scale required by the quantization and which we shall refer to as polymer length. The dynamics of the polymer oscillator can be given the form of that for the standard quantum pendulum. Depending on the dominance of the polymer length we can distinguish two regimes: vibrational and rotational. The first occur for small polymer length and here the standard oscillator in Schr\"odinger quantization is recovered at leading order. The second one, for large polymer length, features dominant polymer effects. In the case of the polymer particles in the box, a bounded and oscillating spectrum that presents a band structure and a Brillouin zone is found. The thermodynamical quantities calculated with these spectra have corrections with respect to standard ones and they depend on the polymer length. For generic polymer length, thermodynamics of both systems present an anomalous peak in their heat capacity $C_V$.

The relativistic equilibrium velocity distribution plays a key role in describing several high-energy and astrophysical effects. Recently, computer simulations favored Juttner's as the relativistic generalization of Maxwell's distribution for d=1,2,3 spatial dimensions and pointed to an invariant temperature. In this work we argue an invariant temperature naturally follows from manifest covariance. We present a new derivation of the manifestly covariant Juttner's distribution and Equipartition Theorem. The standard procedure to get the equilibrium distribution as a solution of the relativistic Boltzmann's equation is here adopted. However, contrary to previous analysis, we use cartesian coordinates in d+1 momentum space, with d spatial components. The use of the multiplication theorem of Bessel functions turns crucial to regain the known invariant form of Juttner's distribution. Since equilibrium kinetic theory results should agree with thermodynamics in the comoving frame to the gas the covariant pseudo-norm of a vector entering the distribution can be identified with the reciprocal of temperature in such comoving frame. Then by combining the covariant statistical moments of Juttner's distribution a novel form of the Equipartition Theorem is advanced which also accommodates the invariant comoving temperature and it contains, as a particular case, a previous not manifestly covariant form., Comment: 21 pages, 1 figure