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184 results on '"Dagher, Nabil N."'

2. Colony-stimulating factor 1 receptor inhibition prevents microglial plaque association and improves cognition in 3xTg-AD mice

Author

Dagher, Nabil N, Najafi, Allison R, Kayala, Kara M Neely, Elmore, Monica RP, White, Terra E, Medeiros, Rodrigo, West, Brian L, and Green, Kim N

Subjects
Biomedical and Clinical Sciences, Neurosciences, Immunology, Dementia, Neurodegenerative, Behavioral and Social Science, Aging, Alzheimer's Disease, Brain Disorders, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Acquired Cognitive Impairment, Neurological, Alzheimer Disease, Animals, Anxiety, Brain, Cell Count, Cell Line, Chemotaxis, Cognition Disorders, Dose-Response Relationship, Drug, Humans, Learning, Memory, Mice, Mice, Transgenic, Microglia, Motor Activity, Plaque, Amyloid, Receptors, Granulocyte-Macrophage Colony-Stimulating Factor, Alzheimer's disease, Neuroinflammation, Cognition, Therapeutics, Clinical Sciences, Neurology & Neurosurgery
Abstract

BackgroundMicroglia are dependent upon colony-stimulating factor 1 receptor (CSF1R) signaling for their survival in the adult brain, with administration of the dual CSF1R/c-kit inhibitor PLX3397 leading to the near-complete elimination of all microglia brainwide. Here, we determined the dose-dependent effects of a specific CSF1R inhibitor (PLX5622) on microglia in both wild-type and the 3xTg-AD mouse model of Alzheimer's disease.MethodsWild-type mice were treated with PLX5622 for up to 21 days, and the effects on microglial numbers were assessed. 3xTg-AD mice were treated with PLX5622 for 6 or 12 weeks and effects on microglial numbers and pathology subsequently assessed.ResultsHigh doses of CSF1R inhibitor eliminate most microglia from the brain, but a 75% lower-dose results in sustained elimination of ~30 of microglia in both wild-type and 3xTg-AD mice. No behavioral or cognitive deficits were found in mice either depleted of microglia or treated with lower CSF1R inhibitor concentrations. Aged 3xTg-AD mice treated for 6 or 12 weeks with lower levels of PLX5622 resulted in improved learning and memory. Aβ levels and plaque loads were not altered, but microglia in treated mice no longer associated with plaques, revealing a role for the CSF1R in the microglial reaction to plaques, as well as in mediating cognitive deficits.ConclusionsWe find that inhibition of CSF1R alone is sufficient to eliminate microglia and that sustained microglial elimination is concentration-dependent. Inhibition of the CSF1R at lower levels in 3xTg-AD mice prevents microglial association with plaques and improves cognition.

Published
2015

4. Clinical and Financial Implications of 2 Treatment Strategies for Donor-derived Hepatitis C Infections

Author

Stewart, Zoe A., Stern, Jeffrey, Ali, Nicole M., Kalia, Harmit S., Khalil, Karen, Jonchhe, Srijana, Weldon, Elaina P., Dieter, Rebecca A., Lewis, Tyler C., Funches, Nur, Crosby, Sudara, Seow, Monique, Berger, Jonathan C., Dagher, Nabil N., Gelb, Bruce E., Watkins, Anthony C., Moazami, Nader, Smith, Deane E., Kon, Zachary N., Chang, Stephanie H., Reyentovich, Alex, Angel, Luis F., Montgomery, Robert A., and Lonze, Bonnie E.

Published
2021
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5. Colony-Stimulating Factor 1 Receptor Signaling Is Necessary for Microglia Viability, Unmasking a Microglia Progenitor Cell in the Adult Brain

Author

Elmore, Monica  R.P., Najafi, Allison R., Koike, Maya  A., Dagher, Nabil  N., Spangenberg, Elizabeth  E., Rice, Rachel  A., Kitazawa, Masashi, Matusow, Bernice, Nguyen, Hoa, West, Brian  L., and Green, Kim N.

Subjects
kinase inhibitor, langerhans cells, rat-brain, in-vivo, a-beta, macrophages, expression, growth, differentiation, monocytes
Published
2014

7. Successful Treatment of Tenofovir Alafenamide-Induced Lactic Acidosis: A Case Report.

Author

Arnouk, Serena, Whitsett, Maureen, Papadopoulos, John, Stewart Lewis, Zoe, Dagher, Nabil N., Feldman, David M., and Park, James S.

Subjects
THERAPEUTIC use of ubiquinones, VITAMIN B2, TENOFOVIR, LACTIC acidosis, CIRRHOSIS of the liver, HEPATITIS, MITOCHONDRIA, VITAMIN B1, DNA polymerases, PHOSPHORYLATION, DISEASE complications
Abstract

Nucleoside or nucleotide analogues (NAs) have the potential to cause lactic acidosis by inhibiting DNA polymerase-γ of human mitochondria and impairing aerobic metabolism. Patients may be asymptomatic, have mild non-specific symptoms, or present in multisystem organ failure. There is a paucity of data to guide management of life-threatening lactic acidosis due to NA therapy. Here we describe a case of a 60-year old critically ill male with decompensated cirrhosis secondary to hepatitis B virus (HBV) infection who developed severe lactic acidosis (13.8 mmol/L) 2 days after initiation of tenofovir alafenamide (TAF). All other possible etiologies for the elevated lactate were ruled out. Lactic acidosis resolved rapidly with TAF discontinuation and supplementation with cofactors supporting mitochondrial oxidative phosphorylation, including coenzyme Q10, levocarnitine, riboflavin, and thiamine. This case highlights the ability of TAF to cause lactic acidosis early after therapy initiation, especially in susceptible hosts, and reviews the potential role for cofactor supplementation for drug-induced mitochondrial injury. [ABSTRACT FROM AUTHOR]

Published
2023
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21. Comparison of Non-Tumoral Portal Vein Thrombosis Management in Cirrhotic Patients: TIPS Versus Anticoagulation Versus No Treatment

Author

Zhan, Chenyang, primary, Prabhu, Vinay, additional, Kang, Stella K., additional, Li, Clayton, additional, Zhu, Yuli, additional, Kim, Sooah, additional, Olsen, Sonja, additional, Jacobson, Ira M., additional, Dagher, Nabil N., additional, Carney, Brendan, additional, Hickey, Ryan M., additional, and Taslakian, Bedros, additional

Published
2021
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22. Cholangiopathy After Severe COVID-19: Clinical Features and Prognostic Implications

Author

Faruqui, Saamia, primary, Okoli, Fidelis C., additional, Olsen, Sonja K., additional, Feldman, David M., additional, Kalia, Harmit S., additional, Park, James S., additional, Stanca, Carmen M., additional, Figueroa Diaz, Viviana, additional, Yuan, Sarah, additional, Dagher, Nabil N., additional, Sarkar, Suparna A., additional, Theise, Neil D., additional, Kim, Sooah, additional, Shanbhogue, Krishna, additional, and Jacobson, Ira M., additional

Published
2021
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25. Contributors

Author

Abcarian, Herand, primary, Abdullah, Fizan, additional, Abramson, Michael A., additional, Abularrage, Christopher J., additional, Adams, Reid B., additional, Adamski, John., additional, Ahrendt, Steven A., additional, Ahuja, Nita, additional, Alam, Hasan B., additional, Alverdy, John C., additional, Armstrong, David N., additional, Arnaoutakis, George J., additional, Arnold, Alejandro, additional, Arthurs, Zachary M., additional, Asbun, Horacio J., additional, Ascher, Nancy L., additional, Asgeirsson, Theodor, additional, Ashley, Stanley W., additional, Babiera, Gildy V., additional, Balcom, James H., additional, Balogh, Zsolt J., additional, Banki, Farzaneh, additional, Barbul, Adrian, additional, Barie, Philip S., additional, Bauer, Todd W., additional, Beck, David E., additional, Bedri, Mazen I., additional, Berenji, Manijeh, additional, Berger, David L., additional, Bergman, Thomas A., additional, Berry, Stepheny D., additional, Billingham, Richard P., additional, Birnbaum, Elisa H., additional, Black, James H., additional, Bland, Kirby I., additional, Bochicchio, Grant V., additional, Bouchard, Philippe, additional, Boughey, Judy C., additional, Bowers, Steven P., additional, Brady, Colin M., additional, Brandes, Steven B., additional, Brant-Zawadzki, Peter, additional, Brayman, Kenneth L., additional, Brethauer, Stacy A., additional, Brock, Malcolm V., additional, Brooke, Benjamin S., additional, Broome, James T., additional, Brown, Carl J., additional, Brunicardi, F. Charles, additional, Brushart, Thomas M., additional, Buchman, Timothy G., additional, Bulger, Eileen M., additional, Burns, J. Bracken, additional, Busuttil, Ronald W., additional, Byrne, John, additional, Callender, Glenda G., additional, Callery, Mark P., additional, Cambria, Richard P., additional, Cameron, Andrew M., additional, Cameron, John L., additional, Campsen, Jeffrey, additional, Caprini, Joseph A., additional, Carter, Jonathan, additional, Caudle, Abigail S., additional, Ceppa, Eugene P., additional, Cevasco, Marisa, additional, Chaikof, Elliot L., additional, Chalikonda, Sricharan, additional, Chandrasekhara, Vinay, additional, Chaudhry, Vivek, additional, Chen, Haiquan, additional, Chen, Herbert, additional, Cheng, Aaron M., additional, Choti, Michael A., additional, Christians, Kathleen K., additional, Christmas, A. Britton, additional, Chua, Heidi, additional, Chun, Albert K., additional, Chung, Alice, additional, Clark, Orlo H., additional, Cleary, Sean P., additional, Cocanour, Christine S., additional, Codner, Panna A., additional, Cogbill, Thomas H., additional, Collier, Patrick S., additional, Conrad, Mark F., additional, Cooper, Joel D., additional, Corning, Cybil, additional, Cortes, Vicente, additional, Coselli, Joseph S., additional, Craft, Randall O., additional, Croce, Martin A., additional, Crow, Jessica, additional, Cuff, Robert F., additional, Cullen, Joseph J., additional, Cunningham, Steven C., additional, Curet, Myriam J., additional, Dackiw, Alan P.B., additional, Dagher, Nabil N., additional, Darling, R. Clement, additional, Davidson, Nancy E., additional, Degliuomini, John J., additional, Degnim, Amy C., additional, Delaney, Conor P., additional, DeMatteo, Ronald P., additional, DeMeester, Steven R., additional, DeMeester, Tom R., additional, Dempsey, Daniel T., additional, deSouza, Ashwin L., additional, Deune, E. Gene, additional, DeVos, Wayne C., additional, Dimick, Justin B., additional, Donahue, Timothy R., additional, Dort, Jonathan M., additional, Dozois, Eric J., additional, Dreesen, Elizabeth, additional, Duh, Quan-Yang, additional, Dulchavsky, Scott A., additional, Duncan, Mark D., additional, Duvvuri, Umamaheshwar, additional, Eachempati, Soumitra R., additional, Eakin, Jeffrey, additional, Eckhauser, Frederic E., additional, Edil, Barish H., additional, Edwards, Eric D., additional, Edwards, Meghan, additional, Efron, David T., additional, Efron, Jonathan E., additional, Efron, Philip A., additional, Ellison, E. Christopher, additional, Ellison, Trevor A., additional, El Sherif, Amgad, additional, Escobar, Guillermo A., additional, Esposito, Domenic P., additional, Evans, Douglas B., additional, Evans, Heather L., additional, Fabri, Peter J., additional, Fairman, Ronald M., additional, Farres, Houssam, additional, Feins, Richard H., additional, Feliciano, David V., additional, Ferguson, Charles M., additional, Ferguson, Mark K., additional, Ferrone, Cristina R., additional, Ferzli, George S., additional, Fichera, Alessandro, additional, Fink, Aaron S., additional, Fink, David, additional, Fishel, Rhonda, additional, Fisher, Kerry, additional, Fisher, William E., additional, Fitzgibbons, Timothy C., additional, Fleshman, James W., additional, Flint, Lewis M., additional, Flohr, Tanya R., additional, Flores, Jaime I., additional, Fogarty, Sara P., additional, Foley, Paul J., additional, Fong, Yuman, additional, Friel, Charles M., additional, Frykberg, Eric R., additional, Fuller, Joseph C., additional, Gadd, Michele A., additional, Gailloud, Philippe, additional, Galanis, Charles, additional, Gallagher, James J., additional, Gallagher, Scott F., additional, Gaspard, Bryan A., additional, Gaughan, Colleen B., additional, Gearhart, Susan L., additional, Geller, David A., additional, Georgiades, Christos S., additional, Geschwind, Jean-Francois H., additional, Ghosheh, Bashar, additional, Giday, Samuel A., additional, Giuliano, Armando E., additional, Glebova, Natalia, additional, Goldberg, Nelson H., additional, Goldstone, Jerry, additional, Golla, Suman, additional, Gosnell, Jessica E., additional, Gourley, Jeffrey R., additional, Graham, Jay A., additional, Grams, Jayleen, additional, Grant, Michael P., additional, Grau, Ana M., additional, Grothey, Axel, additional, Guerrero, Marlon A., additional, Guillem, Jose G., additional, Haider, Adil H., additional, Hall, Bruce Lee, additional, Han, David C., additional, Harmon, John W., additional, Harold, Kristi L., additional, Harper, Amy P., additional, Harris, Hobart W., additional, Hashimi, Samad, additional, Hassoun, Heitham T., additional, Haut, Elliott R., additional, Hébert-Blouin, Marie-Noëlle, additional, Heitmiller, Richard F., additional, Henderson, J. Michael, additional, Heniford, B. Todd, additional, Henke, Peter K., additional, Herlong, H. Franklin, additional, Hernandez, Jonathan M., additional, Hess, Philip J., additional, Hiatt, Jonathan R., additional, Hines, O. Joe, additional, Hodin, Richard A., additional, Hoffman, John P., additional, Hong, Johnny C., additional, Hoppo, Toshitaka, additional, Horn, Jan K., additional, Hornicek, Francis J., additional, Hossain, Rydhwana, additional, Howard, Thomas J., additional, Hoyt, David B., additional, Hrabe, Jennifer E., additional, Hranjec, Tjasa, additional, Hull, Tracy L., additional, Iannettoni, Mark D., additional, Iannitti, David A., additional, Idrees, Kamran, additional, Ignacio, Elizabeth A., additional, Iseli, Tim A., additional, Ito, Hiromichi, additional, Jacene, Heather, additional, Jackson, Lana L., additional, Jacobs, Lenworth M., additional, Jacobs, Lisa K., additional, Jagannath, Sanjay, additional, Jaszczak, Nicholas, additional, Jayaraman, Vijay, additional, Jimenez, Juan Carlos, additional, Jin, Judy, additional, Jobe, Blair A., additional, Joh, Jennifer E., additional, Johnson, Eric K., additional, Johnson, Jonas T., additional, Johnson, Lynt B., additional, Johnson, Michael, additional, Jonnalagadda, Sreenivasa, additional, Jurkovich, Gregory J., additional, Kachala, Stefan S., additional, Kalloo, Anthony N., additional, Karakousis, Giorgos C., additional, Katz, Ryan D., additional, Keane, Thomas, additional, Kebebew, Electron, additional, Kent, K. Craig, additional, Kent, Tara S., additional, Khashab, Mouen, additional, Kilic, Arman, additional, Hui Kim, Elizabeth Min, additional, Kim, Yongsik, additional, King, Jonathan C., additional, King, Tari A., additional, Kirkpatrick, Andrew W., additional, Kong, Allen, additional, Kozarek, Richard A., additional, Krasna, Mark J., additional, Krontiras, Helen, additional, Kuwayama, David, additional, Lai, Edward C.S., additional, Lal, Alysandra, additional, LaMuraglia, Glenn M., additional, Lau, Kwan N., additional, Lavu, Harish, additional, Lawrence, Peter F., additional, LeBlanc, Karl A., additional, Ledgerwood, Anna M., additional, LeMaire, Scott A., additional, Lembersky, Barry C., additional, Leukhardt, William H., additional, Li, Ryan, additional, Lillemoe, Keith D., additional, Lipsett, Pamela A., additional, Lipsitz, Evan C., additional, Little, Alex G., additional, Lucas, Charles E., additional, Luketich, James D., additional, Lum, Ying Wei, additional, Lyden, Sean P., additional, MacFadyen, Bruce V., additional, Madariaga, Maria Lucia L., additional, Magnuson, Thomas H., additional, Maier, Ronald V., additional, Makary, Martin A., additional, Makhija, Rohit, additional, Malangoni, Mark A., additional, Malas, Mahmoud B., additional, Manson, Paul N., additional, Marcello, Peter W., additional, Marks, Jeffrey M., additional, Marohn, Michael R., additional, Martin, Terri R., additional, Martin, Tomas D., additional, Mathisen, Douglas J., additional, Matthews, Brent D., additional, Mazzaglia, Peter J., additional, McDermott, John E., additional, McFadden, David W., additional, McHenry, Christopher R., additional, McIntyre, Robert C., additional, McLemore, Elisabeth C., additional, McLeod, Robin S., additional, Mellinger, John D., additional, Melo, Nicholas, additional, Melton, Genevieve B., additional, Meltzer, Andrew J., additional, Melvin, W. Scott, additional, Mendoza, Maria Clara, additional, Messiner, Ryan, additional, Meyer, Anthony A., additional, Meyers, William C., additional, Michelassi, Fabrizio, additional, Millikan, Keith W., additional, Miner, Thomas J., additional, Moley, Jeffrey F., additional, Moore, Frederick A., additional, Morrow, Ellen H., additional, Morrow, Monica, additional, Moss, Angela K., additional, Moustarah, Fady, additional, Mufeed, Sami, additional, Muldoon, Roberta L., additional, Muniappan, Ashok, additional, Murphy, Erin H., additional, Muscarella, Peter, additional, Nahabedian, Maurice Y., additional, Napolitano, Lena M., additional, Nealon, William H., additional, Neideen, Todd, additional, Neumayer, Leigh A., additional, Newman, Naeem A., additional, Nguyen, Hien T., additional, Nguyen, Kevin Tri, additional, Nikfarjam, Mehrdad, additional, Norton, Jeffrey A., additional, O'Mara, Charles S., additional, Onders, Raymond P., additional, Pachter, H. Leon, additional, Pappas, Theodore N., additional, Parikh, Manish, additional, Park, Jason, additional, Pascual, Jose L., additional, Patel, Virendra I., additional, Pearl, Russell K., additional, Peitzman, Andrew B., additional, Pemberton, John H., additional, Perler, Bruce A., additional, Perrier, Nancy D., additional, Pesce, Catherine E., additional, Petelin, Joseph B., additional, Peters, Jeffrey H., additional, Petrowsky, Henrik, additional, Pfluke, Jason M., additional, Philipp, Scott R., additional, Phillips, Bradley J., additional, Piper, Greta L., additional, Pitt, Henry A., additional, Pizano, Louis R., additional, Ponsky, Jeffrey L., additional, Prescott, Jason D., additional, Pronovost, Peter J., additional, Pust, Gerd D., additional, Pustavoitau, Aliaksei, additional, Puyana, Juan Carlos, additional, Qazi, Umair, additional, Quickel, Robert R., additional, Ra, Jin H., additional, Rad, Ariel N., additional, Radvany, Martin G., additional, Rafferty, Janice F., additional, Rahbari, Reza, additional, Ramos, Margarita, additional, Ramshaw, Bruce J., additional, Rawlings, Arthur, additional, Reardon, Patrick R., additional, Reber, Howard A., additional, Reeder, Jennifer G., additional, Reidy, Tobi, additional, Reifsnyder, Andrew, additional, Reifsnyder, Thomas F., additional, Resnick, Andrew S., additional, Richards, William O., additional, Rieder, Erwin, additional, Roberts, John P., additional, Robinson, Raymond E., additional, Robinson, Thomas N., additional, Rodriguez, Aurelio, additional, Rodriguez-Paz, Jose M., additional, Rogers, Selwyn O., additional, Romig, Mark, additional, Roseborough, Glen S., additional, Rosemurgy, Alexander S., additional, Rosenthal, Eben L., additional, Rossi, Daniel C., additional, Rosson, Gedge D., additional, Safar, Bashar, additional, Salky, Barry A., additional, Santora, Rachel J., additional, Sarin, Shawn N., additional, Sawyer, Robert G., additional, Sax, Harry C., additional, Scalea, Thomas M., additional, Schauer, Philip R., additional, Schild, A. Frederick, additional, Schmidt, C. Max, additional, Schneider, John G., additional, Schreiber, Martin A., additional, Schuerer, Douglas J.E., additional, Schulick, Richard D., additional, Schwab, C. William, additional, Schweitzer, Michael A., additional, Scortino, Christopher, additional, Senagore, Anthony J., additional, Sentovich, Stephen M., additional, Sepesi, Boris, additional, Seybt, Melanie W., additional, Shah, Amit, additional, Shellito, Paul C., additional, Shepard, Alexander D., additional, Shetty, Kirti, additional, Sicklick, Jason K., additional, Silberfein, Eric J., additional, Silverman, Ronald P., additional, Simmons, Rache M., additional, Sing, Ronald F., additional, Smith, Barbara L., additional, Smith, C. Daniel, additional, Smith, Maurice A., additional, Smith, R. Stephen, additional, Snyder, Michael J., additional, Sohn, Helen, additional, Soybel, David I., additional, Spencer, Michael P., additional, Spinner, Robert J., additional, Spoerke, Nicholas J., additional, Steele, Scott R., additional, Stein, Sharon L., additional, Stevens, Kent A., additional, Sticca, Robert P., additional, Stiegmann, Gregory V., additional, Stonemetz, Jerry, additional, Strasberg, Steven M., additional, Streiff, Michael B., additional, Su, Stacey, additional, Sucher, Joseph F., additional, Sussman, Marc, additional, Sutherland, David E.R., additional, Swanstrom, Lee L., additional, Taghizadeh, Maakan, additional, Talamini, Mark A., additional, Tarpley, John L., additional, Tatli, Servet, additional, Taylor, Spence M., additional, Terris, David J., additional, Thompson, Geoffrey B., additional, Traverso, L. William, additional, Trunkey, Donald D., additional, Tsai, Peter I., additional, Tsai, Susan, additional, Tsangaris, Theodore N., additional, Udelsman, Robert, additional, Umanskiy, Konstantin, additional, Upchurch, Gilbert R., additional, Urist, Marshall M., additional, Urschel, Harold C., additional, Vagefi, Parsia A., additional, Van, Philbert Y., additional, Van Arendonk, Kyle J., additional, Vauthey, Jean-Nicolas, additional, Veeramachaneni, Nirmal K., additional, Velmahos, George C., additional, Venbrux, Anthony C., additional, Vollmer, Charles M., additional, Wacker, Frank K., additional, Wallack, Marc K., additional, Walsh, R. Matthew, additional, Wang, Grace J., additional, Wang, Jennifer Y., additional, Wang, Thomas N., additional, Waters, Joshua A., additional, Watkins, Michael T., additional, Watson, Christopher M., additional, Webb, Alexandra L.B., additional, Weigelt, John A., additional, Weiss, Eric G., additional, Whang, Edward E., additional, Whitacre, Eric B., additional, Williams, D. Brandon, additional, Wolff, Bruce G., additional, Wolfgang, Christopher, additional, Wong, Patricia, additional, Wood, Douglas E., additional, Yadav, Bhupender, additional, Yang, Stephen C., additional, Yeo, Charles J., additional, Yoon, Sam S., additional, You, Christopher J., additional, You, Y. Nancy, additional, Youssef, Yassar, additional, Zalinski, Stéphane, additional, Zamir, Gideon A., additional, Zarins, Christopher K., additional, Zeiger, Martha A., additional, Zenilman, Michael E., additional, and Zimmerman, Michael A., additional

Published
2011
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27. Contributors

Author

Alder, Adam C., primary, Barloco, Severn, additional, Beck, Adam W., additional, Bell, Christopher, additional, Blumetti, Jennifer, additional, Brazda, Amy, additional, Brakenridge, Scott, additional, Broker, Harshal, additional, Chambers, James A., additional, Crawford, Kevin, additional, Curtis, David, additional, Dagher, Nabil N., additional, Dineen, Sean, additional, Eastman, Alexander, additional, Ellis, Henry, additional, Foteh, Kousta I., additional, Gary, Joshua L., additional, Garza, Robert, additional, Gedeon, Makram, additional, Gillespie, Richard M., additional, Grimes, Julie, additional, Hall, Jason, additional, Harzman, Alan E., additional, Hershberger, Richard, additional, Islam, Arsalla, additional, lyengar, Radha, additional, Jacks, Samuel, additional, Jaiswal, Kshama, additional, Kane, Lauren, additional, King, Jarrod, additional, Klein, Jorie, additional, Khosla, Rohit K., additional, Labat, Marc, additional, Lau, Lee Ann, additional, Lipschitz, Avron, additional, McCarley, Clifann, additional, McDougal, Jennifer L., additional, Miller, Barbra S., additional, Miller, Meredith, additional, Mitchell, Ian, additional, Oleksy, Brian, additional, Olson, Craig, additional, Peltz, Matthias, additional, Pierce, Damon S., additional, Roland, Christina, additional, Roller, Josh, additional, Rosenbaum, David H., additional, Rosenbaum, Frances, additional, Schmidt, Kelly, additional, Schumacher, Paul, additional, Siragusa, Tif, additional, Smith, Stephen, additional, Smith, Taylor, additional, Stuke, Lance E., additional, Sweeney, Patrick T., additional, Thakar, Hemangini, additional, Vela, Steven A., additional, Venkatesh, Krishna, additional, Walsh, Lance, additional, and Woodruff, Stacey, additional

Published
2009
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31. Frailty and Delayed Graft Function in Kidney Transplant Recipients

Author

Garonzik-Wang, Jacqueline M., Govindan, Priyanka, Grinnan, Jack W., Liu, Minghao, Ali, Hassan M., Chakraborty, Anindita, Jain, Vaibhav, Ros, Reside L., James, Nathan T., Kucirka, Lauren M., Hall, Erin C., Berger, Jonathan C., Montgomery, Robert A., Desai, Niraj M., Dagher, Nabil N., Sonnenday, Christopher J., Englesbe, Michael J., Makary, Martin A., Walston, Jeremy D., and Segev, Dorry L.

Published
2012
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34. Hepatic Artery Microvascular Anastomosis in Liver Transplantation: A Systematic Review of the Literature

Author

Kantar, Rami S., primary, Berman, Zoe P., additional, Diep, Gustave K., additional, Ramly, Elie P., additional, Alfonso, Allyson R., additional, Sosin, Michael, additional, Lee, Z-Hye, additional, Rifkin, William J., additional, Kaoutzanis, Christodoulos, additional, Yu, Jason W., additional, Ceradini, Daniel J., additional, Dagher, Nabil N., additional, and Levine, Jamie P., additional

Published
2020
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43. Single-Center Experience in Pre-transplant Hepatitis C Virus (HCV) Treatment Among Living Donor Liver Transplant Candidates: Bridging the Direct-Acting Antivirals (DAA).

Author

Niranjan-Azadi, Ashwini M., Kabacam, Gokhan, Durand, Christine M., Anjum, Saad, Saberi, Behnam, Dagher, Nabil N., Philosophe, Benjamin, and Gurakar, Ahmet

Subjects
HEPATITIS C treatment, LIVER transplantation, ORGAN donors, ANTIVIRAL agents, DISEASE relapse, PULMONARY hypertension
Abstract

Background: Treatment with DAAs before deceased donor liver transplantation has been shown to be an effective strategy to prevent post-transplant HCV recurrence, with a 95% cure-rate among individuals who achieve undetectable HCV VL for ≥30 days pre-transplant. This strategy has not been evaluated in LDLT. Material/Methods: We evaluated outcomes in LDLT recipients treated with DAAs pre-transplant and bridged with 4 weeks of posttransplant SOF. All cases of LDLT at Johns Hopkins (1/1/2014-3/1/15) were retrospectively reviewed. Results: There were 4 HCV+ LDLT cases treated with DAAs pre- and post-transplant. Pre-transplant DAA regimens included SOF plus SIM in 2 cases of HCC and SOF plus RBV in 2 cases of ESLD. All patients achieved negative VL by week 7 of treatment and all patients had at least 30 days of HCV RNA negativity at the time of LDLT. Patient 4 had a delay in LDLT due to uncontrolled pulmonary hypertension, and experienced viral breakthrough because of treatment interruption. Due to concerns for SOF resistance, a salvage regimen of LDV-SOF and SIM was used. Post-LDLT patients 1-3 received 4 weeks of SOF monotherapy and patient 4 received 14 weeks of LDV-SOF. Three patients achieved SVR12. One died from non-HCV related complications at 4 months post-LDLT. Conclusions: Our preliminary experience suggests that bridging DAAs pre- and post-LDLT is an effective strategy to prevent HCV recurrence. With delays in transplant and prolonged use of SOF/RBV, there is a risk of viral breakthrough, but a salvage strategy of triple DAA therapy can be effective. [ABSTRACT FROM AUTHOR]

Published
2018
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44. Surgical management of early and late ureteral complications after renal transplantation: techniques and outcomes

Author

Berli, Jens U., primary, Montgomery, John R., additional, Segev, Dorry L., additional, Ratner, Lloyd E., additional, Maley, Warren R., additional, Cooper, Matthew, additional, Melancon, Joseph K., additional, Burdick, James, additional, Desai, Niraj M., additional, Dagher, Nabil N., additional, Lonze, Bonnie E., additional, Nazarian, Susanna M., additional, and Montgomery, Robert A., additional

Published
2014
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46. Sarcopenia Adversely Impacts Postoperative Complications Following Resection or Transplantation in Patients with Primary Liver Tumors

Author

Valero, Vicente, primary, Amini, Neda, additional, Spolverato, Gaya, additional, Weiss, Matthew J., additional, Hirose, Kenzo, additional, Dagher, Nabil N., additional, Wolfgang, Christopher L., additional, Cameron, Andrew A., additional, Philosophe, Benjamin, additional, Kamel, Ihab R., additional, and Pawlik, Timothy M., additional

Published
2014
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47. Eculizumab and Splenectomy as Salvage Therapy for Severe Antibody-Mediated Rejection After HLA–Incompatible Kidney Transplantation

Author

Orandi, Babak J., primary, Zachary, Andrea A., additional, Dagher, Nabil N., additional, Bagnasco, Serena M., additional, Garonzik-Wang, Jacqueline M., additional, Van Arendonk, Kyle J., additional, Gupta, Natasha, additional, Lonze, Bonnie E., additional, Alachkar, Nada, additional, Kraus, Edward S., additional, Desai, Niraj M., additional, Locke, Jayme E., additional, Racusen, Lorraine C., additional, Segev, Dorry L., additional, and Montgomery, Robert A., additional

Published
2014
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48. Contributors

Author

Abbas, Abbas El-Sayed, Abdullah, Fizan, Abood, Gerard J., Abularrage, Christopher J., AbuRahma, Ali F., AbuRahma, Zachary T., Adams, David B., Afaneh, Cheguevara, Agopian, Vatche G., Ahmed, Ali Karim, Ahrendt, Steven A., Ahuja, Nita, Ahuja, Nitin K., Alarcon, Louis H., Albuja-Cruz, Maria B., Althans, Alison R., Althumairi, Azah A., Alverdy, John C., Anandam, Joselin L., Androes, Mark P., Ansari, Amir Mehdi, Arnaoutakis, Dean J., Arnold, Meghan A., Atallah, Chady I., Auchincloss, Hugh G., Axtell, Andrea L., Ayoung-Chee, Patricia, Azad, Nilofer, Azar, Faris K., Azoury, Saïd C., Bailey, Christina E., Bailey, Ian B., Balch, Charles M., Balch, Glen C., Ball, Chad G., Bandyk, Dennis F., Barie, Philip S., Bates, Andrew, Battafarano, Richard, Beard, Kristin Wilson, Beaulieu, Peter, Beaulieu, Robert J., Bedine, Marshall S., Bedzra, Edo K.S., Beekmann, Susan E., Behrns, Kevin E., Bellistri, John-Paul, Bello, Ricardo J., Benrashid, Ehsan, Berger, David L., Berian, Julia R., Bilimoria, Karl Y., Bjurlin, Marc A., Black, James H., III, Bland, Kirby, Blas, Joseph-Vincent V., Bleier, Joshua I., Blumetti, Jennifer, Bodzin, Adam, Boone, Brian A., Born, Louis J., Boughey, Judy C., Boyett, Daniel, Brady, Justin T., Brennan, Murray F., Brenner, Bruce M., Britt, L.D., Brock, Malcolm, Brownie, Evan R., Brunicardi, F. Charles, Brunt, L. Michael, Burgess, Jessica, Burke, Mark S., Burlew, Clay Cothren, Bush, Errol, Busuttil, Ronald W., Caffrey, Julie, Callender, Glenda G., Cambria, Richard P., Cameron, Andrew M., Camp, Melissa S., Campbell, Kurtis A., Carr, Shamus R., Cavnar, Michael J., Chaikof, Elliot L., Champagne, Bradley J., Haito Chavez, Yamile, Chen, Herbert, Chen, Yen-I, Chi, Albert, Chockalingam, Arun, Cholewczynski, Walter, Choti, Michael A., Christakis, Ioannis A., Christante, Dara H., Cintron, Jose R., Claridge, Jeffrey A., Clark, Damon, Cody, Hiram S., III, Cogbill, Thomas H., Cohan, Jessica N., Cooney, Damon S., Cooper, Zara, Corey, Britney L., Coté, Gregory A., Cox, Morgan L., Crawford, Todd C., Croce, Martin A., Cryer, H. Gill, Cuff, Robert F., Cunningham, Steven C., Dackiw, Alan P.B., Dagher, Nabil N., Dart, Benjamin W., IV, Datta, Jashodeep, Dattilo, Jeffery B., Davis, Bradley, Davis, Donald, Delaney, Conor P., Delman, Keith, DeMatteo, Ronald P., DeMeester, Steven R., DeMeester, Tom R., Dempsey, Daniel T., DiBrito, Sandra R., Dimick, Justin B., Dimou, Francesca M., Dixon, Peter, Donahue, James, Duh, Quan-Yang, Duncan, Mark, Durand, Christine M., Durazo, Francisco A., Earle, David, Edil, Barish H., Efron, David T., Efron, Jonathan E., Ehlert, Bryan A., Eisele, David W., Elliott, David, English, Sean J., Eriksen, Calvin, Eslami, Mohammad H., Esquivel, Jesus, Euhus, David M., Eun, John C., Evans, Douglas B., Evans, Heather L., Fabian, Timothy C., Fabri, Peter J., Fabrizio, Anne C., Fagenholz, Peter J., Fakhry, Carole, Fang, Sandy H., Fantus, Richard J., Feldman, Liane S., Feliciano, David V., Feller-Kopman, David, Ferrada, Paula A., Ferrari, Linda, Ferson, Peter F., Fichera, Alessandro, Fiedler, Amy G., Finnerty, Brendan M., Fischer, Josef E., Fisichella, P. Marco, Fleshman, James W., Fong, Zhi Ven, Forthman, Christopher L., Francone, Todd D., Frankel, Heidi, Franklin, David P., Gahtan, Vivian, Galandiuk, Susan, Gallagher, James J., Gangi, Alexandra, Garvey, Erin M., Gearhart, Susan L., Geiger, Timothy M., Gemignani, Mary L., Georgiades, Christos, Georgoff, Patrick E., Geschwind, Jean-Francois H., Gestring, Mark L., Ghaderi, Iman, Giglia, Joseph S., Giuliano, Armando E., Glebova, Natalia O., Gleisner, Ana L., Goldin, Steven B., Goldstein, Seth, Goodenough, Christopher J., Goussous, Naeem, Graham, Jay A., Grandhi, Miral Sadaria, Grant, Clive S., Gray, Richard J., Gregg, Shea C., Gribovskaja-Rupp, Irena, Griffen, Margaret M., Griffin, James F., Grimm, Joshua C., Guillem, Jose G., Ha, Jinny, Habib, Fahim, Hackam, David, Hamilton, James P., Harken, Alden H., Harmon, John W., Hartney, Mark, Hassoun, Heitham T., Haugen, Christine E., Haut, Elliott R., He, Jin, Hébert-Blouin, Marie-Noëlle, Helmink, Beth A., Henderson, David K., Heniford, B. Todd, Herline, Alan, Herman, Joseph M., Hicks, Caitlin W., Hines, O. Joe, Hogg, Melissa E., Holly, Brian P., Hong, Kelvin, Howley, Isaac W., Hoyler, Margo, Hughes, Kevin S., Hughes, Steven J., Hungness, Eric S., Hunter, John G., Hutcheon, David F., Hutter, Matthew M., Hyman, Neil H., Ignacio, Elizabeth Ann, Ijaz, Nadia, Jacobs, Lisa K., Jakhete, Neha, Jenkins, Donald H., Jensen, Robert T., Jha, Reena, Jobe, Blair A., Johnson, Eric K., Johnson, Lynt B., Joseph, Bellal, Jurkovich, Gregory J., Kadera, Brian, Kahan, Stacie A., Kaldas, Fady M., Kalloo, Anthony N., Kao, Lillian S., Kapadia, Muneera R., Kaplan, Lewis J., Kaups, Krista L., Kebebew, Electron, Kelley, Scott R., Kelly, Ronan, Kent, K. Craig, Khashab, Mouen A., Khouri, Nagi, Kim, Amy K., Kim, Karen M., Kiraly, Laszlo, Kirane, Amanda, Kleiman, David A., Klimberg, V. Suzanne, Klinger, Kerry, Knab, L. Mark, Kowdley, Gopal C., Kozarek, Richard A., Krampitz, Geoffrey W., Krezalek, Monika A., Krontiras, Helen, Krpata, David M., Kugler, Nathan, Kulkarni, Swati A., Kumbhari, Vivek, Kuwada, Timothy, Kuwayama, David, LaFace, Angela, LaMuraglia, Glenn M., Lancaster, R. Todd, Landreneau, Rodney J., Langan, Russell C., Lange, Julie R., Lay, Frank, Ledgerwood, Anna M., Lee, Andrew J., Leeper, W. Robert, Lehenbauer, David, Liddell, Robert P., Lidor, Anne, Lightner, Amy L., Lillemoe, Keith D., Lilley, Elizabeth J., Liu, Jieqiong, Liu, Yuk Ming, Loiacono, Laurie A., Lombardo, KMarie Reid, Lonze, Bonnie E., Loomis, Erica A., Lou, Irene, Lucas, Charles E., Luketich, James D., Lum, Ying Wei, Lunsford, Keri E., Lynch, Kevin, MacGillivray, Thomas E., Mackersie, Robert C., Magnuson, Thomas, Maier, Ronald V., Makary, Martin A., Makris, Konstantinos, Malangoni, Mark A., Malas, Mahmoud B., Maley, Warren R., Manson, Paul N., Mansour, M. Ashraf, Marmor, Rebecca A., Marti, Guy P., Martin, Laura, Martindale, Robert G., Mason, Leonard L., III, Mathew, Sarah Jean, Mathis, Kellie L., Mathisen, Douglas J., Matsangos, Aerielle E., Matthews, Jeffrey B., Maxwell, Robert, McCartan, Damian, McFadden, David W., McHenry, Christopher R., McIntyre, Robert C., Jr., McQuay, Nathaniel, Jr., Melancon, Joseph K., Menaker, Jay, Meneshian, Avedis, Menon, Raman, Meyer, Anthony A., Meyers, William C., Michelassi, Fabrizio, Mier, Fernando, Milner, Stephen M., Miraflor, Emily, Mitchem, Jonathan B., Moalem, Jacob, Modi, Rushabh, Molena, Daniela, Moore, Forrest O'dell, Moore, Scott M., Morse, Christopher R., Mullinax, John, Mureebe, Leila, Murphy, Adrian, Muscarella, Peter, II, Mustain, W. Conan, Myzak, Melinda Cherie, Napolitano, Lena M., Nealon, William Hawe, Netz, Uri, Neumayer, Leigh, Newman, Lisa, Ng, Christopher, Ng, Gladys, Nguyen, Hien T., Nilubol, Naris, Norton, Jeffrey A., O’Connell, Kathleen M., O’Keeffe, Terence, Okolo, Patrick I., III, O’Mara, Charles S., Osgood, Greg, Osgood, Michael J., Pachter, H. Leon, Paniccia, Alessandro, Pappas, Sam G., Pappas, Theodore N., Park, Pauline K., Parker, Catherine, Parthasarathy, Madhumithaa, Pasternak, Jesse D., Patel, Dhaval, Patel, Jayshil J., Patel, Madhukar S., Patel, Nishant, Patel, Shirali T., Paul, Jasmeet Singh, Pawlik, Timothy M., Pegoli, Walter, Jr., Peitzman, Andrew B., Pennathur, Arjun, Perler, Bruce A., Perone, Jennifer A., Perrier, Nancy D., Peters, Walter R., Phelan, Patrick J., Philosophe, Benjamin, Pieracci, Fredric M., Pitt, Henry A., Plichta, Jennifer K., Ponsky, Jeffrey L., Poor, Alexander E., Poruk, Katherine E., Prakash, Priya, Prescott, Jason D., Price, Leigh Ann, Pryor, Aurora D., Puig, Carlos A., Raeburn, Christopher D., Raigani, Siavash, Ramsay, Philip T., Rashidi, Laila, Rattner, David, Reid, Trista, Reifsnyder, Thomas, Reynolds, Jessica K., Riall, Taylor S., Rivere, Amy, Rizvi, Addi Z., Robinson, Bryce R.H., Robinson, Thomas N., Rodriguez, Aurelio, Rodriguez, John H., Rosemurgy, Alexander S., II, Rosen, Michael J., Rosso, Kelly J., Rosson, Gedge D., Rotondo, Michael F., Rueda, Mario, Ryan, Mark L., Ryer, Evan J., Sacks, Justin M., Salles, Arghavan, Santos, Byron F., Sarr, Michael G., Saur, Nicole M., Scalea, Thomas M., Schaetzel, Shaina, Schaheen, Lara, Schimpf, Dennis K., Schlachter, Todd, Schulick, Richard D., Schwartz, Diane A., Schweitzer, Michael A., Sciortino, Christopher, Semaan, Roy, Senagore, Anthony J., Shah, Amar, Shakoor, Aqsa, Shapiro, A.M. James, Shaw, Palma, Shepard, Alexander D., Sheridan, Robert, Shermak, Michele A., Sicklick, Jason K., Silverstein, Melvin, Simmons, Justin M., Sims, Carrie, Sise, Michael, Smith, Barbara L., Soares, Kevin C., Sonntag, David, Sosa, Julie A., Spain, David A., Spinner, Robert J., Stahl, Richard D., Stanley, Gregory A., Stanley, J. Daniel, Steele, Scott R., Stefanidis, Dimitrios, Stein, Sharon, Steurer, Marc P., Stevens, Kent A., Stone, Patrick A., Stonemetz, Jerry, Strasberg, Steven M., Streiff, Michael B., Stulberg, Jonah J., Sugimoto, Motokazu, Susarla, Srinivas M., Swann, Jacob, Swanstrom, Lee L., Talamini, Mark A., Tam, Vernissia, Tanabe, Kenneth K., Tarpley, John L., Taylor, Spence M., Teicher, Erik J., Teitelbaum, Ezra N., Thompson, Jon S., Thorsen, Amy J., Tieu, Alan H., Traverso, L. William, Tsai, Susan, Tsitskari, Maria, Tufaro, Anthony P., Turley, Ryan S., Udelsman, Robert, Umphrey, Heidi, Urist, Marshall, Varma, Madhulika G., Velanovich, Vic, Velmahos, George, Villano, Anthony M., Vito, Courtney A., Vollmer, Charles M., Jr., Vyas, Nilesh A., Wall, Matthew J., Jr., Waltz, Paul, Wang, Tracy S., Watkins, Michael T., Watson, Ryan S., Weaver, M. Libby, Weaver, Mitchell R., Webb, Travis P., Weber, Cynthia E., Weiss, Eric G., Weiss, Matthew J., Werner, Nicole L., Wexner, Steven D., Whyte, Richard, Wick, Elizabeth C., Wiesel, Ory, Wilson, Alison M., Wilson, Jennifer L., Winner, Megan, Witkowski, Elan R., Witkowski, Piotr, Wolf, Joshua H., Wolfgang, Christopher L., Wood, Douglas E., Wright, Cameron D., Yeo, Charles J., Yeo, Heather, Yi, Jeniann, Youngwirth, Linda M., Zarnegar, Rasa, Zeh, Herbert J., III, Zeiger, Martha A., Zenilman, Michael E., Zhan, Luke X., Zosa, Brenda M., Zoumberos, Melissa Silva, Zuberi, Kashif A., Zureikat, Amer H., and Zyromski, Nicholas J.

Published
2017
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