Search

Aim: Central sensitization‑related neuroaudiological symptoms are frequently seen in patients with fibromyalgia syndrome (FMS). This study aimed to evaluate the audiological signs and symptoms in patients with FMS and explore their relationship with oxidative stress markers.Methods: This prospective controlled cross‑sectional study compared the serum myeloperoxidase, superoxide dismutase, glutathione peroxidase (GPx), nitric oxide (NO), and malondialdehyde (MDA) concentrations in 44 patients with FMS diagnosed according to the 2010 American College of Rheumatology criteria and 44healthy volunteers. FMS severity was assessed using the visual analog scale and Fibromyalgia Impact Questionnaire. An audiological assessment including vocalizations, vertigo, balance problems, and hearing problems was done to all participants.Results: The two groups were of similar age (P = 0.24), gender (P = 0.40), and weight distribution (P = 0.6). Vertigo, tinnitus, hearing, and balance complaints (P = 0.01/P = 0.00/P = 0.00/P = 0.01) were significantly higher in the FMS group. All subunits and total scores of dizziness handicap inventory were significantly higher (P = 0.00/P = 0.00/P = 0.01/P = 0.01) in the FMS group. An antioxidant GPx and oxidant parameters such as NO and MDA were found to be significantly higher (P = 0.00/P = 0.01/P = 0.02). The hearing assessments at frequencies between 250 and 12,000 Hz showed a significant difference between the two groups (high hearing frequencies in the FMS group) in audiometry. No significant difference was found between the two groups in terms of the presence of stabilo‑acoustic reflex, intraaural pressure, and compliance (P = 0.18/P = 0.33/P = 0.41) in tympanogram.Conclusions: Patients with FMS have high levels of oxidative stress markers (GPx, NO, and MDA), highly frequent audiological symptoms with high hearing frequencies in audiometry, independent of disease severity.Keywords: Audiologic disorders, fibromyalgia, oxidative stress

Aim: The aim of this study was to evaluate the protective effects of dietary syringic acid (SA) on the development and severity of cerulein-induced acute pancreatitis (AP) in rats in terms of biochemical and histopathologic changes. Material and Method: 24 rats were divided into 3 equal groups. Three groups were compared in terms of the levels of oxidative stress, antioxidant markers, pancreatic enzymes, and histopathological changes. This study was approved by the ethics committee of our university and the project was supported by the scientific research unit (project number 2016 / 3-43 D). Results: In the pancreatitis group, the amylase and lipase values were significantly higher and oxidative stress markers were significantly elevated; the Glutathione peroxidase (GSH-Px) level was found to be significantly decreased in the pancreatitis group compared to the control and treatment groups. Apoptosis and cellular damage level results were significantly higher in the pancreatitis group, while cellular damage in the treatment group was significantly lower (P < 0.05) than in the pancreatitis group. Discussion: Although a syringic acid diet does not totally prevent AP, it has been shown to decrease the severity of AP on both enzymatic and histopathological levels.