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1,211 results on '"Daha, M"'

2. Optimizing Signal Detection in MIMO Systems: AI vs Approximate and Linear Detectors

Author

Daha, M. Y., Khurshid, Kiran, Ashraf, M. I., and Hadi, M. U.

Abstract

Artificial intelligence has transformed multiple input multiple output (MIMO) technology into a promising candidate for six-generation networks. However, several interference signals impact the data transmission between various antennas; therefore, sophisticated signal detection techniques are required at the MIMO receiver to estimate the transmitted data. This letter presents an optimized AI-based signal detection technique called AIDETECT for MIMO systems. The proposed AIDETECT network model is developed based on an optimized deep neural network (DNN) architecture, whose efficiency lies in its lightweight network architecture. To train and test the AIDETECT network model, we generate and process the data in a suitable form based on the transmitted signal, channel information, and noise. Based on this data, we calculate the received signal at the receiver end, where the received signal and channel information were integrated into the AIDETECT network model to perform reliable signal detection. Simulation results show that at a 20-dB signal-to-noise ratio (SNR), the proposed AIDETECT technique achieves between 97.33% to 99.99% better performance compared to conventional MIMO detectors and is also able to accomplish between 25.34% to 99.98% better performance than other AI-based MIMO detectors for the considered performance metrics. In addition, due to lightweight network architecture, the proposed AIDETECT technique has also achieved much lower computational complexity than conventional and AI-based MIMO detectors.

Published
2024
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8. Bortezomib, C1-Inhibitor and Plasma Exchange Do Not Prolong the Survival of Multi-Transgenic GalT-KO Pig Kidney Xenografts in Baboons

Author

Le Bas-Bernardet, S., Tillou, X., Branchereau, J., Dilek, N., Poirier, N., Châtelais, M., Charreau, B., Minault, D., Hervouet, J., Renaudin, K., Crossan, C., Scobie, L., Takeuchi, Y., Diswall, M., Breimer, M. E., Klar, N., Daha, M. R., Simioni, P., Robson, S. C., Nottle, M. B., Salvaris, E. J., Cowan, P. J., dʼApice, A. J. F., Sachs, D. H., Yamada, K., Lagutina, I., Duchi, R., Perota, A., Lazzari, G., Galli, C., Cozzi, E., Soulillou, J.-P., Vanhove, B., and Blancho, G.

Published
2015
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9. Pentraxin-3-mediated complement activation in a swine model of renal ischemia/reperfusion injury

Author

Divella, C., Stasi, A., Franzin, R., Rossini, M., Pontrelli, P., Sallustio, F., Netti, G. S., Ranieri, E., Lacitignola, L., Staffieri, F., Crovace, A. M., Lucarelli, G., Ditonno, P., Battaglia, M., Daha, M. R., van der Pol, P., van Kooten, C., Grandaliano, Giuseppe, Gesualdo, L., Stallone, G., Castellano, G., Grandaliano G. (ORCID:0000-0003-1213-2177), Divella, C., Stasi, A., Franzin, R., Rossini, M., Pontrelli, P., Sallustio, F., Netti, G. S., Ranieri, E., Lacitignola, L., Staffieri, F., Crovace, A. M., Lucarelli, G., Ditonno, P., Battaglia, M., Daha, M. R., van der Pol, P., van Kooten, C., Grandaliano, Giuseppe, Gesualdo, L., Stallone, G., Castellano, G., and Grandaliano G. (ORCID:0000-0003-1213-2177)

Abstract

Pentraxins are a family of evolutionarily conserved pattern recognition molecules with pivotal roles in innate immunity and inflammation, such as opsonization of pathogens during bacterial and viral infections. In particular, the long Pentraxin 3 (PTX3) has been shown to regulate several aspects of vascular and tissue inflammation during solid organ transplantation. Our study investigated the role of PTX3 as possible modulator of Complement activation in a swine model of renal ischemia/reperfusion (I/R) injury. We demonstrated that I/R injury induced early PTX3 deposits at peritubular and glomerular capillary levels. Confocal laser scanning microscopy revealed PTX3 deposits co-localizing with CD31+ endothelial cells. In addition, PTX3 was associated with infiltrating macrophages (CD163), dendritic cells (SWC3a) and myofibroblasts (FSP1). In particular, we demonstrated a significant PTX3-mediated activation of classical (C1q-mediated) and lectin (MBL-mediated) pathways of Complement. Interestingly, PTX3 deposits co-localized with activation of the terminal Complement complex (C5b-9) on endothelial cells, indicating that PTX3-mediated Complement activation occurred mainly at the renal vascular level. In conclusion, these data indicate that PTX3 might be a potential therapeutic target to prevent Complement-induced I/R injury.

Published
2021

29. Integrating Metabolomics, Genomics, and Disease Pathways in Age-Related Macular Degeneration: The EYE-RISK Consortium

Author

ACAR, I. E., LORES-MOTTA, L., COLIJN, J. M., MEESTER-SMOOR, M. A., Verzijden, T., Cougnard-Gregoire, Audrey, Ajana, Soufiane, MERLE, Benedicte, de Breuk, A., HEESTERBEEK, T. J., Van Den Akker, E., DAHA, M. R., Claes, B., PAULEIKHOFF, D., HENSE, H. W., VAN DUIJN, C. M., Fauser, S., HOYNG, C. B., DELCOURT, Cecile, KLAVER, C. C. W., GALESLOOT, T. E., DEN HOLLANDER, A. I., Radboud University Medical Center [Nijmegen], Bordeaux population health (BPH), and Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
Ophthalmology, genetic structures, Urological cancers Radboud Institute for Health Sciences [Radboudumc 15], Vascular damage Radboud Institute for Health Sciences [Radboudumc 16], [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, sense organs, [SDV.MHEP.OS]Life Sciences [q-bio]/Human health and pathology/Sensory Organs, eye diseases, Sensory disorders Donders Center for Medical Neuroscience [Radboudumc 12]
Abstract

Contains fulltext : 229444.pdf (Publisher’s version ) (Open Access) PURPOSE: The current study aimed to identify metabolites associated with age-related macular degeneration (AMD) by performing the largest metabolome association analysis in AMD to date, as well as aiming to determine the effect of AMD-associated genetic variants on metabolite levels and investigate associations between the identified metabolites and activity of the complement system, one of the main AMD-associated disease pathways. DESIGN: Case-control association analysis of metabolomics data. PARTICIPANTS: Five European cohorts consisting of 2267 AMD patients and 4266 control participants. METHODS: Metabolomics was performed using a high-throughput proton nuclear magnetic resonance metabolomics platform, which allows quantification of 146 metabolite measurements and 79 derivative values. Metabolome-AMD associations were studied using univariate logistic regression analyses. The effect of 52 AMD-associated genetic variants on the identified metabolites was investigated using linear regression. In addition, associations between the identified metabolites and activity of the complement pathway (defined by the C3d-to-C3 ratio) were investigated using linear regression. MAIN OUTCOME MEASURES: Metabolites associated with AMD. RESULTS: We identified 60 metabolites that were associated significantly with AMD, including increased levels of large and extra-large high-density lipoprotein (HDL) subclasses and decreased levels of very low-density lipoprotein (VLDL), amino acids, and citrate. Of 52 AMD-associated genetic variants, 7 variants were associated significantly with 34 of the identified metabolites. The strongest associations were identified for genetic variants located in or near genes involved in lipid metabolism (ABCA1, CETP, APOE, and LIPC) with metabolites belonging to the large and extra-large HDL subclasses. Also, 57 of 60 metabolites were associated significantly with complement activation levels, independent of AMD status. Increased large and extra-large HDL levels and decreased VLDL and amino acid levels were associated with increased complement activation. CONCLUSIONS: Lipoprotein levels were associated with AMD-associated genetic variants, whereas decreased essential amino acids may point to nutritional deficiencies in AMD. We observed strong associations between the vast majority of the AMD-associated metabolites and systemic complement activation levels, independent of AMD status. This may indicate biological interactions between the main AMD disease pathways and suggests that multiple pathways may need to be targeted simultaneously for successful treatment of AMD.

Published
2020
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36. Complement activation levels are related to disease stage in AMD

Author

Lechanteur, Y, Heesterbeek, T, Lorés-Motta, L, Schick, T, Daha, M, Altay, L, Liakopoulos, S, Smailhodzic, D, den Hollander, A, Hoyng, C, de Jong, E, Klevering, B, Lechanteur, Y, Heesterbeek, T, Lorés-Motta, L, Schick, T, Daha, M, Altay, L, Liakopoulos, S, Smailhodzic, D, den Hollander, A, Hoyng, C, de Jong, E, and Klevering, B

Published
2020

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