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Your search keyword '"Dai, Lupeng"' showing total 8 results
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8 results on '"Dai, Lupeng"'

1. Spatiotemporal single‐cell transcriptomic profiling reveals inflammatory cell states in a mouse model of diffuse alveolar damage

Author

Su, Duo, primary, Jiao, Zhouguang, additional, Li, Sha, additional, Yue, Liya, additional, Li, Cuidan, additional, Deng, Mengyun, additional, Hu, Lingfei, additional, Dai, Lupeng, additional, Gao, Bo, additional, Wang, Jinglin, additional, Zhang, Hanchen, additional, Xiao, Haihua, additional, Chen, Fei, additional, Yang, Huiying, additional, and Zhou, Dongsheng, additional

Published
2023
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3. Construction of a Live-Attenuated Vaccine Strain of Yersinia pestis EV76-B-SHUΔpla and Evaluation of Its Protection Efficacy in a Mouse Model by Aerosolized Intratracheal Inoculation

Author

Feng, Junxia, primary, Deng, Yingying, additional, Fu, Mengjiao, additional, Hu, Xueyuan, additional, Luo, Wenbo, additional, Lu, Zhiyu, additional, Dai, Lupeng, additional, Yang, Huiying, additional, Zhao, Xiaodong, additional, Du, Zongmin, additional, Wen, Bohai, additional, Jiang, Lingxiao, additional, Zhou, Dongsheng, additional, Jiao, Jun, additional, and Xiong, Xiaolu, additional

Published
2020
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4. Pathologic changes and immune responses against Coxiella burnetii in mice following infection via non-invasive intratracheal inoculation

Author

Hu, Xueyuan, primary, Yu, Yonghui, additional, Feng, Junxia, additional, Fu, Mengjiao, additional, Dai, Lupeng, additional, Lu, Zhiyu, additional, Luo, Wenbo, additional, Wang, Jinglin, additional, Zhou, Dongsheng, additional, Xiong, Xiaolu, additional, Wen, Bohai, additional, Zhao, Baohua, additional, and Jiao, Jun, additional

Published
2019
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5. Enhanced protection against Q fever in BALB/c mice elicited by immunization of chloroform-methanol residue of Coxiella burnetii via intratracheal inoculation

Author

Feng, Junxia, primary, Hu, Xueyuan, additional, Fu, Mengjiao, additional, Dai, Lupeng, additional, Yu, Yonghui, additional, Luo, Wenbo, additional, Zhao, Zengming, additional, Lu, Zhiyu, additional, Du, Zongmin, additional, Zhou, Dongsheng, additional, Wen, Bohai, additional, Jiao, Jun, additional, and Xiong, Xiaolu, additional

Published
2019
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6. A Mouse Model of Acute Q Fever Following Infection Via A Non-Invasive Intratracheal Inoculation Method

Author

Hu, Xueyuan, primary, Yu, Yonghui, additional, Feng, Junxia, additional, Fu, Mengjiao, additional, Dai, Lupeng, additional, Lu, Zhiyu, additional, He, Zemin, additional, Luo, Wenbo, additional, Xiong, Xiaolu, additional, Wang, Jinglin, additional, Zhou, Dongsheng, additional, Wen, Bohai, additional, Zhao, Baohua, additional, and Jiao, Jun, additional

Published
2019
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7. Construction of a Live-Attenuated Vaccine Strain of Yersinia pestis EV76-B-SHUΔ pla and Evaluation of Its Protection Efficacy in a Mouse Model by Aerosolized Intratracheal Inoculation.

Author

Feng, Junxia, Deng, Yingying, Fu, Mengjiao, Hu, Xueyuan, Luo, Wenbo, Lu, Zhiyu, Dai, Lupeng, Yang, Huiying, Zhao, Xiaodong, Du, Zongmin, Wen, Bohai, Jiang, Lingxiao, Zhou, Dongsheng, Jiao, Jun, and Xiong, Xiaolu

Subjects
YERSINIA pestis, VACCINATION, PLASMINOGEN, DELETION mutation, PLASMINOGEN activators, COMMUNICABLE diseases
Abstract

Plague, which is caused by Yersinia pestis , is one of the most dangerous infectious diseases. No FDA-approved vaccine against plague is available for human use at present. To improve the immune safety of Y. pestis EV76 based live attenuated vaccine and to explore the feasibility of aerosolized intratracheal inoculation (i.t.) route for vaccine delivery, a plasminogen activator protease (pla) gene deletion mutant of the attenuated Y. pestis strain EV76-B-SHU was constructed, and its residual virulence and protective efficacy were evaluated in a mouse model via aerosolized intratracheal inoculation (i.t.) or via subcutaneous injection (s.c.). The residual virulence of EV76-B-SHUΔ pla was significantly reduced compared to that of the parental strain EV76-B-SHU following i.t. and s.c. infection. The EV76-B-SHUΔ pla induced higher levels of mucosal antibody sIgA in the bronchoalveolar lavage fluid of mice immunized by i.t. but not by s.c.. Moreover, after lethal challenge with Y. pestis biovar Microtus strain 201 (avirulent in humans), the protective efficacy and bacterial clearance ability of the EV76-B-SHUΔ pla -i.t. group were comparable to those of the EV76-B-SHUΔ pla -s.c. and EV76-B-SHU immunized groups. Thus, the EV76-B-SHUΔ pla represents an excellent live-attenuated vaccine candidate against pneumonic plague and aerosolized i.t. represents a promising immunization route in mouse model. [ABSTRACT FROM AUTHOR]

Published
2020
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8. Frontispiece: Spatiotemporal single‐cell transcriptomic profiling reveals inflammatory cell states in a mouse model of diffuse alveolar damage (EXP2 3/2023)

Author

Su, Duo, Jiao, Zhouguang, Li, Sha, Yue, Liya, Li, Cuidan, Deng, Mengyun, Hu, Lingfei, Dai, Lupeng, Gao, Bo, Wang, Jinglin, Zhang, Hanchen, Xiao, Haihua, Chen, Fei, Yang, Huiying, and Zhou, Dongsheng

Abstract

This study presents a comprehensive cellular atlas describing the ongoing pulmonary immune responses in the early stages of diffuse alveolar damage. This work indicates a vital role of the hyper‐inflammatory fibroblast subset around the bronchus, in mediating neutrophil infiltration through secreting soluble signaling mediators, thus boosting neutrophilic airway inflammation.

Published
2023
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