Search

HLA‐DRB1*14:07:03 differs from HLA‐DRB1*14:07:01 by one nucleotide in exon 2. [ABSTRACT FROM AUTHOR]

In order to overcome the shortcomings of traditional subspace algorithm that required lots of receiving symbols to compute the autocorrelation matrix and had slow convergence and so on, this paper presented a new fast convergence of subspace-based blind channel estimation algorithm for the Multi-Input Multi-Output Orthogonal Frequency Division Multiplexing (MIMO-OFDM) wireless communication system. Through the block matrix scheme, the channel matrix was turned to be block Toeplitz matrix. Without changing the block Toeplitz matrices, a large number of sub-vectors were formed from the stacked OFDM signal. By using the sub-vector samples, an accurate estimation of auto-correlation matrix could be obtained with fewer received block. The proposed method had the advantages of high estimation accuracy and low computational complexity inherited from traditional subspace algorithm but also relaxed the channel time-invariant requirement and accelerated the convergence speed. Theoretical analysis and simulation results show the effectiveness and better bit error rate performance of the proposed method. [ABSTRACT FROM AUTHOR]

Objective: To explore the effects of blocking TCR-CD3 and B7-CD28 signals on immune function of mice with chronic GVHD by using TJU103 and CTLA4-Ig., Methods: On the basis of foregoing murine model of chronic GVHD, according to interference modes after infusion 6×10 7 spleen cells of donor mice, the recipients were divided into 5 groups: blank control, cGVHD, TJU103 interference, CTLA4-Ig interference and TJU103+CTLA4-Ig interference groups. The score of clinical manifestation and tissue histopathology were used to evaluate the effects of all the interferences on chronic GVHD., Results: TJU103 and CTLA4-Ig could not influence the formation of the mouse chimera. The analysis of Kaplan survival curve of mice with chronic GVHD showed that the CTLA4-Ig and TJU103+CTLA4-Ig reduced the incidence of chronic GVHD, the TJU103 could delay the occurrence of chronic GVHD, but all the interference factors could not change the severity of chronic GVHD., Conclusion: TJU103 can delay the onset time of chronic GVHD, and the CTLA4-Ig can reduce the incidences of cGVHD, the combining use of TJU103 and CTLA4-Ig can significantly reduce the incidence of chronic GVHD, but can not change the severity of chronic GVHD.