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Background The period of junior high school age is a key development stage of adolescent mental health, during which mental maturity and physical and mental development imbalance may greatly increase the susceptibility of the students to depressed mood. Previous studies have shown that yin-deficiency constitution is a risk factor for depressed mood in adolescents, which has also been reported to be impacted by stressful life events and the time taken to fall asleep, but there is no systematic discussion about the mechanism of action in the relationships between the four factors. Objective To explore the relationship between yin-deficiency constitution and depressed mood in junior high school students, as well as the mediating effect of stressful life events and the time taken to fall asleep. Methods On March 2022, a convenient sample of junior high school students from a middle school in Meishan City, Sichuan Province were surveyed on their general data (gender, ethnicity, region of origin, grade), prevalence of yin-deficiency constitution assessed using the yin-deficiency Constitution subscale of the Traditional Chinese Medicine Constitution Scale for 7-14-year-olds, prevalence of stressful life events assessed using the Adolescent Self-Rating Life Events Checklist (ASLEC), and the time taken to fall asleep assessed using the items assessing how long it takes to fall asleep in the Munich Chronotype Questionnaire (MCTQ), and prevalence of depressed mood assessed using the Center for Epidemiologic Studies Depression (CES-D). The scores of yin-deficiency constitution, ASLEC and CES-D as well as the time taken to fall asleep were compared across the students by demographic characteristics. Spearman correlation analysis was used to explore the correlation between the variables. A multiple-mediator model was constructed to examine the mediating effect of stressful life events and the time taken to fall asleep on yin-deficiency constitution and depressed mood, and the significance of chain mediating effect was tested using bootstrap method. Results The survey achieved a response rate of 98.1% (2 570/2 620) in the 2 620 surveyed students. The detection rate of depressed mood in the respondents was 32.8% (844/2 570). Female students had higher scores of yin-deficiency constitution, ASLEC and CES-D than male students (P

Hemophilia is a congenital hemorrhagic disease caused by genetic abnormalities in coagulation factor Ⅷ or factor Ⅸ. Current conventional therapy to prevent bleeding requires frequent intravenous injections of coagulation factor concentrates from early childhood. Hemophilia provides an attractive target for gene therapy studies, due to the monogenic nature of these disorders and easily measurable endpoints (factor levels and bleed rates). All successful, pre-clinical and clinical studies to date have utilized recombinant adeno-associated virus(AAV) vectors for factor Ⅷ or Ⅸ hepatocyte transduction. Although this is likely to alter the paradigm of hemophilia care in the near future, it will be important to overcome immune responses against AAV. This review focuses on current successes of clinical trials, and the future direction of hemophilia gene therapy.

Platinum selenide (PtSe2), an emerging 2D material, has attracted extensive attention owing to its wide‐tunable bandgap and ultrahigh conductivity for potential applications in optoelectronic and energy devices. However, the preparation of atomically thin PtSe2 remains a big challenge due to its large formation energy. Herein, the robust synthesis of large‐area ultrathin PtSe2 microbelts via a step‐induced separation growth strategy on Au(001) substrate is demonstrated. Thanks to the high controllability of this approach, the continuous modulation of the thickness of PtSe2 microbelts from monolayer to bulk is realized and the sample coverage from ≈5% to ≈100% by coordinately tuning the growth temperature and time. Theory calculations indicate that the significant reduction of formation energy of PtSe2 nucleation at the Au steps, along with the high‐efficiency separation‐supply of Pt precursor, are responsible for the robust synthesis of PtSe2. Owing to the rich‐edges with abundant active sites and metallic conduction features of ultrathin PtSe2 microbelt, it can act as an excellent electrocatalyst, featured with a record high hydrogen evolution reaction efficiency (Tafel slope: 37 mV dec−1). This work provides new insights into the highly efficient synthesis of large‐scale 2D materials for exploring their unique physics and fascinating applications. [ABSTRACT FROM AUTHOR]

Alkaline sulfide-rich hot springs provide a unique environment for microbial community and arsenic (As) biogeochemistry. In this study, a representative alkaline sulfide-rich hot spring, Zimeiquan in the Tengchong geothermal area, was chosen to study arsenic geochemistry and microbial community using Illumina MiSeq sequencing. Over 0.26 million 16S rRNA sequence reads were obtained from 5-paired parallel water and sediment samples along the hot spring's outflow channel. High ratios of As(V)/AsSum (total combined arsenate and arsenite concentrations) (0.59-0.78), coupled with high sulfide (up to 5.87 mg/L), were present in the hot spring's pools, which suggested As(III) oxidation occurred. Along the outflow channel, AsSum increased from 5.45 to 13.86 μmol/L, and the combined sulfide and sulfate concentrations increased from 292.02 to 364.28 μmol/L. These increases were primarily attributed to thioarsenic transformation. Temperature, sulfide, As and dissolved oxygen significantly shaped the microbial communities between not only the pools and downstream samples, but also water and sediment samples. Results implied that the upstream Thermocrinis was responsible for the transformation of thioarsenic to As(III) and the downstream Thermus contributed to derived As(III) oxidation. This study improves our understanding of microbially-mediated As transformation in alkaline sulfide-rich hot springs.