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Aims: The extent of perihematomal edema following intracerebral hemorrhage (ICH) significantly impacts patient prognosis, and disruption of the blood–brain barrier (BBB) exacerbates perihematomal edema. However, the role of peripheral IL‐10 in mitigating BBB disruption through pathways that link peripheral and central nervous system signals remains poorly understood. Methods: Recombinant IL‐10 was administered to ICH model mice via caudal vein injection, an IL‐10‐inhibiting adeno‐associated virus and an IL‐10 receptor knockout plasmid were delivered intraventricularly, and neurobehavioral deficits, perihematomal edema, BBB disruption, and the expression of JAK1 and STAT3 were evaluated. Results: Our study demonstrated that the peripheral cytokine IL‐10 mitigated BBB breakdown, perihematomal edema, and neurobehavioral deficits after ICH and that IL‐10 deficiency reversed these effects, likely through the IL‐10R/JAK1/STAT3 signaling pathway. Conclusions: Peripheral IL‐10 has the potential to reduce BBB damage and perihematomal edema following ICH and improve patient prognosis. [ABSTRACT FROM AUTHOR]

This article discusses a study that aimed to evaluate the effectiveness of the inactivated SARS-CoV-2 vaccine (CoronaVac) in patients with psoriasis and atopic dermatitis (AD). The study included 197 participants, including healthy controls, psoriasis patients, and AD patients. The results showed that all groups had enhanced antibody responses to the vaccine after the third dose. However, psoriasis patients who were not receiving treatment had lower antibody levels compared to those receiving anti-IL-17A treatment and healthy controls. The study suggests that correcting the Th1/Th17 imbalance in psoriasis patients may enhance the effectiveness of the COVID-19 vaccine. [Extracted from the article]

Background: The relationship between resting cardiac indices and exercise capacity in older adults was still not well understood. New developments in cardiac magnetic resonance imaging (MRI) enable a much fuller assessment of cardiac characteristics. Purpose/Hypothesis: To assess the association between exercise capacity and specific aspects of resting cardiac structure, function, and tissue. Study Type: Cross‐sectional study. Population: A total of 112 well‐functioning older adults (mean age 69 years, 52 men). Field Strength/Sequence: All participants underwent 3.0 T MRI, using scan protocols including balanced steady‐state free precession cine sequence, modified look‐locker inversion recovery, and T2‐prepared single‐shot balanced steady‐state free precession. Assessment: Demographic and geriatric characteristics were collected. Blood samples were assayed for lipid and glucose related biomarkers. All participants performed a symptom‐limited cardiopulmonary exercise test to achieve peakVO2. Cardiac MRI parameters were measured with semi‐automatic software by S.Y., an 18‐year experienced radiologist. Statistical Tests: Demographic, geriatric characteristics and MR measurements were compared among quartiles of peakVO2, with different methods according to the data type. Spearman's partial correlation and least absolute shrinkage selection operator regression were performed to select significant MR features associated with peakVO2. Mediation effect analysis was conducted to test any indirect connection between age and peakVO2. A two‐sided P value of <0.05 was defined statistical significance. Results: Epicardial fat volume, left atrial volume indexed to height, right ventricular end‐systolic volume indexed to body surface area and global circumferential strain (GCS) were correlated with peakVO2 (regression coefficients were −0.040, −0.093, 0.127, and 0.408, respectively). Mediation analysis showed that the total effect of peakVO2 change was 43.6% from the change of age. The proportion of indirect effect from epicardial fat volume and GCS were 11.8% and 15.1% in total effect, respectively. Data Conclusion: PeakVO2 was associated with epicardial fat volume, left atrial volume, right ventricular volume and GCS of left ventricle. Evidence Level: 4 Technical Efficacy: Stage 5 [ABSTRACT FROM AUTHOR]

The corticocortical vestibular network (CVN) plays an important role in maintaining balance and stability. In order to clarify the specific relationship between the CVN and the balance ability of patients with mild cognitive impairment (MCI), we recruited 30 MCI patients in the community. According to age and sex, they were 1:1 matched to 30 older adults with normal cognitive function. We evaluated balance ability and performed MRI scanning in the two groups of participants. We analyzed functional connectivity within the CVN based on the region of interest. Then, we performed a Pearson correlation analysis between the functional connection and the Berg Balance Scale scores. The research results show that compared with the control group, there were three pairs of functional connections (hMST_R–Premotor_R, PFcm_R–SMA_L, and hMST_L–VIP_R) that were significantly decreased in the CVNs of the MCI group (p < 0.05). Further correlation analysis showed that there was a significant positive correlation between hMST_R–Premotor_R functional connectivity and BBS score (r = 0.364, p = 0.004). The decline in balance ability and increase in fall risk in patients with MCI may be closely related to the change in the internal connection mode of the corticocortical vestibular network. [ABSTRACT FROM AUTHOR]

Simple Summary: Despite the advance in therapeutic strategy, the prognosis of pancreatic ductal adenocarcinoma (PDAC) is still unsatisfactory, with a 5-year survival rate of less than 9%. As a member of the S100 protein family, S100A10 has been identified as an oncogene in multiple cancers. In PDAC, S100A10 has been reported to be not only up-regulated in tumor tissues but also associated with survival outcomes. However, the specific function of S100A10 in PDAC is still unknown. Here, we suggest that S100A10 promotes PDAC cells proliferation, migration, and adhesion by activating JNK/LAMB3-LAMC2 axis in vitro and accelerates pancreatic tumor growth in vivo, indicating that S100A10 may be a potential therapeutic target for PDAC patients. Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive tumors, characterized by diagnosis at an advanced stage and a poor prognosis. As a member of the S100 protein family, S100A10 regulates multiple biological functions related to cancer progression and metastasis. However, the role of S100A10 in PDAC is still not completely elucidated. In this study, we reported that S100A10 was significantly up-regulated in PDAC tissue and associated with a poor prognosis by integrated bioinformatic analysis and human PDAC tissue samples. In vitro, down-regulation of S100A10 reduced the proliferation, migration, and adhesion of PDAC cell lines, whereas up-regulation of S100A10 showed the opposite effect. Furthermore, LAMB3 was proved to be activated by S100A10 using RNA-sequencing and western blotting. The effect of LAMB3 on the proliferation, migration, and adhesion of PDAC cells was similar to that of S100A10. Up-regulation or down-regulation of LAMB3 could reverse the corresponding effect of S100A10. Moreover, we validated S100A10 activates LAMB3 through the JNK pathway, and LAMB3 was further proved to interact with LAMC2. Mice-bearing orthotopic pancreatic tumors showed that S100A10 knocked-down PANC-1 cells had a smaller tumor size than the control group. In conclusion, S100A10 promotes PDAC cells proliferation, migration, and adhesion through JNK/LAMB3-LAMC2 axis. [ABSTRACT FROM AUTHOR]