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Objective To investigate the status quo of self-care self-efficacy among patients with digestive tract cancer, and to explore its influencing factors, in order to provide a basis for making self-management programs for patients with digestive tract cancer. Methods A total of 443 patients with digestive tract tumors admitted to three Grade-A hospitals in Hubei Province from October 2021 to September 2022 were selected as subjects. Convenience sampling method was used to investigate the Chinese version of Strategies Used by People to Promote Health(SUPPH), Social Support Rate Scale(SSRS) and Medical Coping Modes Questionnaire(MCMQ). Results The SUPPH score was (75. 91±15. 64). Gender, place of residence, family per capita monthly income, children, social support and coping style were the main factors affecting the self-management efficacy of patients with digestive tract tumors (P＜0. 05). Conclusion The self-management efficacy of patients with digestive tract tumors is at a medium to low level. Higher level of social support is associated with stronger self-management efficacy of patients. Positive coping style is helpful to improve the self-management efficacy of patients. (目的 了解消化道肿瘤患者自我管理效能感水平现状, 探索其影响因素, 以期为消化道肿瘤患者针对性制定自我管理项目内容提供依据。方法 选取2021年10月—2022年9月湖北省三家三甲医院收治的443例消化道肿瘤患者作为研究对象, 采用便利抽样法, 使用中文版癌症自我管理效能感(SUPPH)、社会支持量表(SSRS)和医学应对方式问卷(MCMQ)进行调查。结果 患者的SUPPH得分为(75. 91±15. 64)分; 性别、居住地、家庭人均月收入、子女情况、社会支持及应对方式是影响消化道肿瘤患者自我管理效能感的主要因素(P

In this paper, the category composition, evaluation tools, influencing factors and intervention methods of symptom clusters of patients with gastric cancer were reviewed, and the problems existing in the existing research were summarized, in order to provide reference for clinical practice and nursing research. (本文从胃癌患者症状群的类别构成、评价工具、影响因素及干预方法进行综述, 并对现有研究中存在的问题进行总结, 以期为临床实践及护理研究提供参考。)

Abstract Selenium (Se) is an essential trace element in human. Recent studies of Se supplementation on the effect of Hashimoto’s thyroiditis (HT) have been reported, but the exact benefit is unclear as well as the underlying immunologic mechanism. We aimed to evaluate the clinical effect of Se supplement in patients with HT, and explore the potential mechanism against thyroid autoimmunity. A prospective, randomized‑controlled study was performed in patients with HT assigned to two groups. Se‐treated group (n = 43) received selenious yeast tablet (SYT) for 6 months, whereas no treatment in control group (n = 47). The primary outcome is the change of thyroid peroxidase antibody (TPOAb) or thyroglobulin antibody (TGAb). Second, thyroid function, urinary iodine, Se, Glutathione peroxidase3 (GPx3), and Selenoprotein P1 (SePP1) levels were measured during the SYT treatment. Meanwhile, regulatory T cells (Tregs) and their subsets activated Tregs (aTregs), resting Tregs, and secreting Tregs, as well as Helios and PD‐1 expression on these cells were also detected. The results showed that SYT treatment significantly decreased TPOAb, TGAb, and thyroid stimulating hormone (TSH) levels, accompanied with the increased Se, GPx3, and SePP1, compared with the control group. Subgroup analysis revealed that subclinical HT may benefit more from this treatment in the decrease of TSH levels by interaction test. Moreover, the percentage of aTregs, Helios/Tregs, and Helios/aTregs were significantly higher in the Se‐treated group than control. In conclusion, Se supplementation may have a beneficial effect on thyroid autoantibodies and thyroid function by increasing the antioxidant activity and upregulating the activated Treg cells.

This paper proposes an online data splicing power flow analysis method based on sensitivity analysis. Since the step-down transformer in the whole network data is usually equivalent to the 220 kV side, the equipment below 220 kV is not modeled in detail, and the provincial network data is modeled to 110kV and 35 kV voltage level equipment in detail. Different levels of modeling have a greater impact on the accuracy of stability analysis and calculation. Therefore, the purpose of improving data accuracy is achieved by splicing the entire network data (external network) and provincial network data (internal network). This paper is based on the sensitivity analysis method to stabilize the tie-line power by adjusting the output of the external network units, and form the whole network data that can accurately analyze the stability characteristics of the provincial network. The problem of power flow deviation caused by the voltage and angle deviation of the nodes at both ends of the regional tie line during the data splicing process is solved. Through the actual application of splicing the entire network and Hunan Provincial Network data, the effectiveness and necessity of the proposed method have been verified.

Dynamic security assessment is widely used in dispatching operation systems, and calculation speed is one of its most important performance indices. In this study, an improved k-nearest neighbour (k-NN) method is proposed aiming to predict the stability indicators of power system, for example, critical clearing time. The method is much faster than the simulation and suitable for online analysis. Firstly, a simulation sample database is constructed based on historical online data and a logistic regression model with least absolute shrinkage and selection operator is trained to pick the stability features, which are chosen from static quantities like running state and active power of electric elements. While a new operation mode needs to be evaluated, a weighted k-NN is implemented to obtain the most familiar samples in the database using the chosen features; the final result will be determined comprehensively by the familiar samples. The validity of the proposed method is verified by simulation using online data of State Grid Corp of China and different key faults. It is proved that the method meets the requirements for speed and accuracy of online analysis system.

Hashimoto thyroiditis (HT) is an autoimmune disease that presumably arises consequent to loss of immune tolerance to autoantigen in thyroid. Regulatory T cells (Tregs) are considered to play a vital role in maintaining the immune balance, as they own intensive suppressive function. This study was undertaken to analyze numbers of Tregs and their expressions of Helios and PD-1 in HT patients. It also aimed to explore the relationship of these with thyroid function and specific autoantibodies. Peripheral blood mononuclear cells (PBMCs) were extracted from blood of 20 healthy controls (HC) and 42 HT patients with varying thyroid functions (10 overt hypothyroidism, 12 subclinical hypothyroidism, and 20 euthyroidism). We performed flow cytometry analysis in PBMCs to detect CD4+CD25+Foxp3+Tregs and their subsets, including CD45RO+Foxp3high activated Treg cells (aTregs), CD45RO-Foxp3low resting Tregs cells (rTregs), and CD45RO+Foxp3low secreting Treg cells (sTregs), as well as the expression of Helios and PD-1 on these cells. The results showed that the percentage of Tregs, aTregs was significantly lower in HT patients and it showed inverse correlation to thyroid function states, in comparison with these in healthy controls. In addition, patients with HT showed decreased expression of Helios in aTregs, while having increased expression of PD-1 in Tregs and sTregs. The levels of Tregs, aTregs, and Helios expressing aTregs were all negatively correlated with antithyroid antibodies. In conclusion, the deficiency of Tregs frequency and aberrant expressions of Helios and PD-1 may possibly contribute to thyroid immune damage in HT.

Large-scale grid integration of renewable energy increases the uncertainty and volatility of power systems, which brings difficulties to output planning and reserve decision-making of power system units. In this paper, we innovatively combined the non-parametric kernel density estimation method and scenario method to describe the uncertainty of renewable energy outputs, and obtained a representative set of renewable energy output scenarios. In addition, we proposed a new method to determine the reserve capacity demand. Further, we derived the quantitative relationship between the reserve demand and the power system reliability index, which was used as the constraint condition of a day-ahead power generation dispatch. Finally, a coordinated dispatching model of power generation and reserve was established, which had the lowest penalty for curtailment of wind power and photovoltaic, as well as the lowest total operating cost for thermal power units, gas power units, and pumped storage power station. By simulating three different working conditions, the proposed model was compared with the traditional deterministic model. Results showed that our proposed method significantly improved system efficiency while maintaining system reliability.

The wind–heat conflict and wind power uncertainty are the main factors leading to the phenomenon of wind curtailment during the heating period in the northern region of China. In this paper, a multi-time scale optimal scheduling strategy for combined heat and power system is proposed. Considering the temporal dependence of wind power fluctuation, the intra-day wind power scenario generation method is put forward, and both day-ahead and intra-day optimization scheduling models based on the scenario method are established to maximize the system’s revenue. The case analyzes the impacts of the initial heat storage capacity of a heat storage device and different scheduling strategies on system revenue. It is verified that the scheduling strategy can better adapt to wind power uncertainty and improve the absorption capacity of wind power, while ensuring the safety and economical efficiency of system operation.

The application of the large-capacity energy storage and heat storage devices in an integrated energy system with a high proportion of wind power penetration can improve the flexibility and wind power accommodation capacity of the system. However, the efficiency and cost of the flexible resource should also be taken into consideration when improving the new energy accommodation capacity. Based on these considerations, the authors try to construct a joint optimal scheduling model for day-ahead energy storage and heat storage that considers flexibility. The power supplies and devices will be modeled separately, which enables a universal applicability. The objective function is the minimum cost and wind curtailment. Various practical constraints are taken into account. The mixed integer programming and software GLPK is used to program and solve. The actual operation data of a provincial power grid in northern China is used to conduct simulation analysis in four different working conditions. The results show that the model can maintain economical efficiency under different working conditions. In addition, it can adjust and dispatch various power supplies and devices efficiently, significantly improving wind power accommodation of the system.

In order to study the change rules of interior acoustic field with the development of cavitation, this article presented a method that through comparing the experiment results with numerical simulation results in cavitation bubbles’ distribution images under different cavitation coefficients to optimize the accuracy of acoustic field simulation using computational fluid dynamics combined with the Lighthill acoustic analogy. First, a closed visual testing system was established based on pump product test system and high-speed photography. Second, the cavitation performance under the rated operating condition was calculated using different cavitation models, in order to obtain both pump cavitation performance curve and distribution of cavitation bubbles. Next, based on the external characteristics experiment and high-speed photography experiment, the appropriate cavitation model for unsteady numerical calculation was selected. On the basis of vapor volume fraction distribution and the cavitation performance curve, four different typical points representing different cavitation coefficients were selected for further analyses. The direct boundary element method was used to calculate the variation characteristics of cavitation-induced noise at different cavitation coefficients. Finally, the peak-to-peak value of pressure fluctuation coefficient is defined as Д, and the pressure pulsating frequency domain signals were analyzed to further study the influence of pressure pulsation on acoustic field. The results show that the effect of pressure pulsation on noise is mainly focused on the discrete eigenvalues, and as for the broadband noise, the influence is not obvious. With the development of cavitation, axial passing frequency, 10- to 100-Hz frequency band, and 1000- to 3000-Hz frequency band show an increasing trend, while blade passing frequency and its harmonic frequencies show a decreasing trend. At the onset of cavitation, 1000- to 3000-Hz frequency band has the highest sensitivity for cavitation detection.

In order to reduce the pollution caused by coal-fired generating units during the heating season, and promote the wind power accommodation, an electrical and thermal system dispatch model based on combined heat and power (CHP) with thermal energy storage (TES) and demand response (DR) is proposed. In this model, the emission cost of CO2, SO2, NOx, and the operation cost of desulfurization and denitrification units is considered as environmental cost, which will increase the proportion of the fuel cost in an economic dispatch model. Meanwhile, the fuel cost of generating units, the operation cost and investment cost of thermal energy storage and electrical energy storage, the incentive cost of DR, and the cost of wind curtailment are comprehensively considered in this dispatch model. Then, on the promise of satisfying the load demand, taking the minimum total cost as an objective function, the power of each unit is optimized by a genetic algorithm. Compared with the traditional dispatch model, in which the environmental cost is not considered, the numerical results show that the daily average emissions CO2, SO2, NOx, are decreased by 14,354.35 kg, 55.5 kg, and 47.15 kg, respectively, and the wind power accommodation is increased by an average of 6.56% in a week.

Polychlorinated biphenyls (PCBs) can severely interfere with multiple animals and human systems. To explore the molecular mechanisms underlying 2, 3', 4, 4', 5- pentachlorobiphenyl (PCB118)-induced thyroid dysfunction, Fischer rat thyroid cell line-5(FRTL-5) cells were treated with either different concentrations of PCB118 or dimethyl sulfoxide (DMSO). The effects of PCB118 on FRTL-5 cells viability and apoptosis were assessed by using a Cell Counting Kit-8 assay and apoptosis assays, respectively. Quantitative real-time polymerase chain reaction was used to quantify protein kinase B (Akt), Forkhead box protein O3a (FoxO3a), and sodium/iodide symporter (NIS) mRNA expression levels. Western blotting was used to detect Akt, phospho-Akt (p-Akt), FoxO3a, phospho-FoxO3a (p-FoxO3a), and NIS protein levels. Luciferase reporter gene technology was used to detect the transcriptional activities of FoxO3a and NIS promoters. The effects of the constitutively active Akt (CA-Akt) and dominant-negative Akt (DN-Akt) plasmids on p-Akt, p-FoxO3a, and NIS levels were examined in PCB118-treated FRTL-5 cells. The effects of FoxO3a siRNA on FoxO3a, p-FoxO3a, and NIS protein levels were examined in the PCB118-treated FRTL-5 cells. The effects of pcDNA3 (plsmid vectors designed for high-level stable and transient expression in mammalian host)-FoxO3a on NIS promoter activity were examined in the PCB118-treated FRTL-5 cells. Our results indicated that relatively higher PCB118 concentrations can inhibit cell viability in a concentration- and time-dependent manner. Akt, p-Akt, and p-FoxO3a protein or mRNA levels increased significantly in PCB118-treated groups and NIS protein and mRNA levels decreased considerably compared with the control groups. FoxO3a promoter activity increased significantly, whereas NIS promoter activity decreased. These effects on p-FoxO3a and NIS could be decreased by the DN-Akt plasmid, enhanced by the CA-Akt plasmid, and blocked by FoxO3a siRNA. The overexpressed FoxO3a could reduce NIS promoter activity. Our results suggested that PCB118 induces thyroid cell dysfunction through the Akt/FoxO3a/NIS signaling pathway.

Purpose. To determine the relationship between Hashimoto’s thyroiditis (HT) and all stages of papillary thyroid carcinoma (PTC) with or without local lymph node metastasis (LNM). Methods. We conducted a retrospective study of thyroidectomies from 2008–2013 in First Affiliated Hospital of Nanjing Medical University. We categorized patients according to the presence of histopathologically proven HT. The prevalence of mPTC (maximum diameter ≤ 10 mm) and crPTC (clinical relevant PTC) and local LNM rates were compared. Results. We evaluated 6,432 consecutive thyroidectomies. In total, 1,328 specimens were confirmed as HT. The prevalence of PTC in this HT cohort was 43.8%, significantly higher than non-HT group. After adjustment of gender and age, the prevalence of PTC was still higher in HT group. HT was a risk factor for PTC in multivariate analysis with odds ratio 2.725 (95% CI, 2.390–3.109) (P

A meta-analysis was performed to assess the association between the PAI-1 -675 4G/5G polymorphism and susceptibility to diabetes mellitus (DM), diabetic nephropathy (DN), diabetic retinopathy (DR) and diabetic coronary artery disease (CAD). A literature-based search was conducted to identify all relevant studies. The fixed or random effect pooled measure was calculated mainly at the allele level to determine heterogeneity bias among studies. Further stratified analyses and sensitivity analyses were also performed. Publication bias was examined by the modified Begg's and Egger's test. Twenty published articles with twenty-seven outcomes were included in the meta-analysis: 6 studies with a total of 1,333 cases and 3,011 controls were analyzed for the PAI-1 -675 4G/5G polymorphism with diabetes risk, 7 studies with 1,060 cases and 1,139 controls for DN risk, 10 studies with 1,327 cases and 1,557 controls for DR and 4 studies with 610 cases and 1,042 controls for diabetic CAD risk respectively. Using allelic comparison (4G vs. 5G), the PAI-1 -675 4G/5G polymorphism was observed to have no significant association with diabetes (REM OR 1.07, 95% CI 0.96, 1.20), DN (REM OR 1.10, 95% CI 0.98, 1.25), DR (REM OR 1.09, 95% CI 0.97, 1.22) or diabetic CAD risk (REM OR 1.07, 95% CI 0.81, 1.42), and similar results were obtained in the dominant, recessive and co-dominant models. Our meta-analyses suggest that the PAI-1 -675 4G/5G polymorphism might not be a risk factor for DM, DN, DR or diabetic CAD risk in the populations investigated. This conclusion warrants confirmation by further studies.

Abstract Background Salinization causes negative effects on plant productivity and poses an increasingly serious threat to the sustainability of agriculture. Wild soybean (Glycine soja) can survive in highly saline conditions, therefore provides an ideal candidate plant system for salt tolerance gene mining. Results As a first step towards the characterization of genes that contribute to combating salinity stress, we constructed a full-length cDNA library of Glycine soja (50109) leaf treated with 150 mM NaCl, using the SMART technology. Random expressed sequence tag (EST) sequencing of 2,219 clones produced 2,003 cleaned ESTs for gene expression analysis. The average read length of cleaned ESTs was 454 bp, with an average GC content of 40%. These ESTs were assembled using the PHRAP program to generate 375 contigs and 696 singlets. The resulting unigenes were categorized according to the Gene Ontology (GO) hierarchy. The potential roles of gene products associated with stress related ESTs were discussed. We compared the EST sequences of Glycine soja to that of Glycine max by using the blastn algorithm. Most expressed sequences from wild soybean exhibited similarity with soybean. All our EST data are available on the Internet (GenBank_Accn: DT082443~DT084445). Conclusion The Glycine soja ESTs will be used to mine salt tolerance gene, whose full-length cDNAs will be obtained easily from the full-length cDNA library. Comparison of Glycine soja ESTs with those of Glycine max revealed the potential to investigate the wild soybean's expression profile using the soybean's gene chip. This will provide opportunities to understand the genetic mechanisms underlying stress response of plants.

The vortex shedding and shock generated inside the pump used in nuclear power plants during operation lead to energy loss and efficiency reduction, and the noise induced by the flow affects the system's safety and reliability. The groove-type geometry of shark skin surface has features such as low hydraulic drag coefficient and low turbulence noise and has been widely applied in energy engineering. This study adopted computational fluid dynamics (CFD) and computational aerodynamic acoustics (CAA) methods to research the effects of Space-V-groove and V-groove bionic impellers on hydraulic performance and acoustic characteristics. In addition, the impacts of both bionic groove geometries on the external characteristics, wall shear stress, blade surface velocity, and vortex core distribution were compared and analyzed. The results found that Space-V-groove can effectively improve hydraulic performance. At the rated flow rate, the drag reduction rates of Space-V-groove and V-groove pumps are 2.86% and 1.82%, while the total sound pressure level is reduced by 1.36% and 1.2%, respectively. The Space-V-groove geometry is more effective in destroying the shedding vortex and trailing vortex, thereby modifying the turbulence in the impeller flow path and reducing energy loss and noise. [ABSTRACT FROM AUTHOR]