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5 results on '"Daiju Hu"'

1. Exons 1–3 deletion in FLCN is associated with increased risk of pneumothorax in Chinese patients with Birt-Hogg-Dubé syndrome

Author

Yue Wang, Mengru Cai, Xianliang Jiang, Guangyu Lv, Daiju Hu, Guofeng Zhang, Jinli Liu, Wei Wei, Jun Xiao, Bing Shen, Jay H. Ryu, and Xiaowen Hu

Subjects
Birt-Hogg-Dubé syndrome, Exons 1–3 deletion, Genotype–phenotype correlation, Pneumothorax, Medicine
Abstract

Abstract Background The pathogenic variants responsible for Birt-Hogg-Dubé syndrome (BHDS) in folliculin (FLCN) gene mostly consist of point mutations. Although large intragenic deletions/duplications have been reported in several case reports, the relationship between large intragenic deletions/duplications and phenotype in BHDS remains unclear. Methods We retrospectively identified and reviewed patients with a large intragenic deletion spanning exons 1–3 and analyzed their phenotypic features to compare with those of point mutation carriers in our hospital from January 1, 2017 to August 31, 2022. Results Twenty unique point mutations (including 4 novel mutations) were detected in 62 patients from 45 families (90%). Exons 1–3 deletion were identified in 8 patients from 5 families (10%) that resided in the same region, Feidong County of Anhui Province, China. Breakpoint analysis indicated that all the deletion breakpoints were flanked by Alu repeats. The prevalence of exons 1–3 deletion carriers in Feidong County was 8.1-times higher than that for BHDS in Anhui Province, suggesting a clustered phenomenon of exons 1–3 deletion. Significantly increased risk of pneumothorax was observed in those with exons 1–3 deletion compared with point mutations (91% vs. 58%, p value 0.047). The risk of renal cancer may be higher in those with exons 1–3 deletion than for those with point mutations (18% vs. 4%, p > 0.05). Conclusions Large intragenic deletion of exons 1–3 in FLCN was identified as a local aggregation phenomenon in Feidong County, China, and was associated with a significantly higher risk of pneumothorax compared to those with point mutations.

Published
2023
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2. Smoking related attention alteration in chronic obstructive pulmonary disease-smoking comorbidity

Author

Feiyan Zeng, Wei Hong, Rujing Zha, Ying Li, Chen Jin, Ying Liu, Hao Liu, Mengqiu Liu, Mei Liu, Fei Xu, Daiju Hu, Hongwen Song, Haiyan Wu, Yongqiang Yu, and Xiaochu Zhang

Subjects
Chronic obstructive pulmonary disease (COPD), Smoking, Comorbidity, Nicotine, Attention ability, Functional magnetic resonance imaging (fMRI), Diseases of the respiratory system, RC705-779
Abstract

Abstract Background Chronic obstructive pulmonary disease (COPD) is a respiratory disease that causes a wide range of cognitive impairments. Although COPD-Smoking comorbidity is common, the relationship between smoking and cognitive function in COPD-Smoking comorbidity remains unclear. This study aimed to investigate the effect of smoking on cognitive function like attention in COPD-Smoking patients. Methods In this study, we used the Montreal Cognitive Assessment (MoCA) scale and resting-state functional magnetic resonance imaging (fMRI) to explore the effect of smoking on attention in patients with COPD. Results Behavioral analysis revealed that among patients with COPD the smokers had a shorter course of COPD and showed a worse attention performance than the non-smokers. Resting-state fMRI analysis revealed that among patients with COPD smokers showed lower regional homogeneity (ReHo) value of the fusiform gyrus than non-smokers. Importantly, the ReHo of the fusiform gyrus is positively associated with attention and mediates the effect of smoking on attention in COPD. Conclusions In summary, our study provides behavioral and neurobiological evidence supporting the positive effect of smoking on attention in COPD. This may be helpful for understanding and treating COPD and even other diseases comorbid with smoking.

Published
2022
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3. Smoking related attention alteration in chronic obstructive pulmonary disease-smoking comorbidity

Author

Feiyan Zeng, Wei Hong, Rujing Zha, Ying Li, Chen Jin, Ying Liu, Hao Liu, Mengqiu Liu, Mei Liu, Fei Xu, Daiju Hu, Hongwen Song, Haiyan Wu, Yongqiang Yu, and Xiaochu Zhang

Subjects
Pulmonary and Respiratory Medicine, Pulmonary Disease, Chronic Obstructive, Smoking, Humans, Attention, Comorbidity, Magnetic Resonance Imaging
Abstract

Background Chronic obstructive pulmonary disease (COPD) is a respiratory disease that causes a wide range of cognitive impairments. Although COPD-Smoking comorbidity is common, the relationship between smoking and cognitive function in COPD-Smoking comorbidity remains unclear. This study aimed to investigate the effect of smoking on cognitive function like attention in COPD-Smoking patients. Methods In this study, we used the Montreal Cognitive Assessment (MoCA) scale and resting-state functional magnetic resonance imaging (fMRI) to explore the effect of smoking on attention in patients with COPD. Results Behavioral analysis revealed that among patients with COPD the smokers had a shorter course of COPD and showed a worse attention performance than the non-smokers. Resting-state fMRI analysis revealed that among patients with COPD smokers showed lower regional homogeneity (ReHo) value of the fusiform gyrus than non-smokers. Importantly, the ReHo of the fusiform gyrus is positively associated with attention and mediates the effect of smoking on attention in COPD. Conclusions In summary, our study provides behavioral and neurobiological evidence supporting the positive effect of smoking on attention in COPD. This may be helpful for understanding and treating COPD and even other diseases comorbid with smoking.

Published
2021

4. Smoking Related Attention Alteration in Chronic Obstructive Pulmonary Disease-Smoking Comorbidity

Author

Mei Liu, Mengqiu Liu, Fei Xu, Xiaochu Zhang, Feiyan Zeng, Rujing Zha, Yongqiang Yu, Daiju Hu, Hao Liu, Ying Li, Ying Liu, Wei Hong, and Hongwen Song

Subjects
medicine.medical_specialty, Text mining, business.industry, Internal medicine, medicine, Pulmonary disease, medicine.disease, business, Comorbidity
Abstract

Chronic obstructive pulmonary disease is a respiratory disease that causes a wide range of cognitive impairments. Although chronic obstructive pulmonary disease-smoking comorbidity is common, the relationship between smoking and cognitive function in chronic obstructive pulmonary disease-smoking comorbidity remains unclear. In this study, we recruited 85 participants, including 42 patients with Chronic obstructive pulmonary disease(20 smokers and 22 non-smokers) and 43 healthy participants(22 smokers and 21 non-smokers). And we used the Montreal Cognitive Assessment scale and resting-state functional magnetic resonance imaging to explore effects of smoking on attention in patients with chronic obstructive pulmonary disease. Behavioral analysis revealed that smokers had a shorter course of chronic obstructive pulmonary disease and showed a worse attention performance in chronic obstructive pulmonary disease-smoking comorbidity compared to non-smokers. Resting-state functional magnetic resonance imaging analysis revealed that smokers showed lower regional homogeneity value of the fusiform gyrus in chronic obstructive pulmonary disease-smoking comorbidity than non-smokers. Importantly, the regional homogeneity of the fusiform gyrus was positively associated with attention and mediates the effect of smoking on attention in chronic obstructive pulmonary disease. In summary, our study provides behavioral and neurobiological evidence supporting the positive effect of smoking on attention in chronic obstructive pulmonary disease. This may be helpful for understanding and treating chronic obstructive pulmonary disease and even other diseases comorbid with smoking.

Published
2021

5. Role of Anti-inflammatory Cytokines IL-35 and IL-37 in Asthma

Author

Daiju Hu

Subjects
0301 basic medicine, Immunology, Inflammation, Disease, Pathogenesis, 03 medical and health sciences, Immune system, medicine, Immunology and Allergy, Animals, Humans, Asthma, business.industry, Interleukins, Interleukin, respiratory system, Eosinophil, medicine.disease, Mucus, respiratory tract diseases, 030104 developmental biology, medicine.anatomical_structure, medicine.symptom, Inflammation Mediators, business, Interleukin-1
Abstract

Asthma is a chronic airway inflammation that is characterized by intense eosinophil infiltrates, mucus hypersecretion, airway remodeling, and airway hyperresponsiveness. Interleukin (IL)-35 and IL-37 are two cytokines with anti-inflammatory effects found in immune response. Recent findings suggested that expressions of IL-35 and IL-37 are abnormal in asthma. Functional analysis further confirmed the important roles of them in the pathogenesis of asthma. The present study reviewed the updated evidence indicating the roles of IL-35 and IL-37 in asthma. Hopefully, the information obtained may lead to a better understanding of the pathogenesis of the disease.

Published
2016

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