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1. Hodge filtrations for twisted parametrically prime divisors

Author

Dakin, Henry

Subjects
Mathematics - Algebraic Geometry
Abstract

We extend previous work to the case of $\mathbb{Q}$-divisors. Namely, for certain parametrically prime holomorphic functions $f$ and $\alpha \geq 0$, we obtain an explicit expression for the Hodge filtration on $\mathscr{M}(f^{-\alpha}):=\mathscr{O}_X(*f)f^{-\alpha}$.

Published
2024

2. Euclid preparation. L. Calibration of the linear halo bias in $\Lambda(\nu)$CDM cosmologies

Author

Euclid Collaboration, Castro, T., Fumagalli, A., Angulo, R. E., Bocquet, S., Borgani, S., Costanzi, M., Dakin, J., Dolag, K., Monaco, P., Saro, A., Sefusatti, E., Aghanim, N., Amendola, L., Andreon, S., Baccigalupi, C., Baldi, M., Bodendorf, C., Bonino, D., Branchini, E., Brescia, M., Caillat, A., Camera, S., Capobianco, V., Carbone, C., Carretero, J., Casas, S., Castellano, M., Castignani, G., Cavuoti, S., Cimatti, A., Colodro-Conde, C., Congedo, G., Conselice, C. J., Conversi, L., Copin, Y., Costille, A., Courbin, F., Courtois, H. M., Da Silva, A., Degaudenzi, H., De Lucia, G., Di Giorgio, A. M., Douspis, M., Dupac, X., Dusini, S., Farina, M., Farrens, S., Ferriol, S., Fosalba, P., Frailis, M., Franceschi, E., Fumana, M., Galeotta, S., Gillis, B., Giocoli, C., Gómez-Alvarez, P., Grazian, A., Grupp, F., Guzzo, L., Haugan, S. V. H., Holmes, W., Hormuth, F., Hornstrup, A., Ilić, S., Jahnke, K., Jhabvala, M., Joachimi, B., Keihänen, E., Kermiche, S., Kiessling, A., Kilbinger, M., Kubik, B., Kunz, M., Kurki-Suonio, H., Lilje, P. B., Lindholm, V., Lloro, I., Maiorano, E., Mansutti, O., Marggraf, O., Markovic, K., Martinelli, M., Martinet, N., Marulli, F., Massey, R., Maurogordato, S., Medinaceli, E., Melchior, M., Mellier, Y., Meneghetti, M., Merlin, E., Meylan, G., Moscardini, L., Munari, E., Niemi, S. -M., Padilla, C., Paltani, S., Pasian, F., Pedersen, K., Percival, W. J., Pettorino, V., Pires, S., Polenta, G., Poncet, M., Popa, L. A., Pozzetti, L., Raison, F., Renzi, A., Riccio, G., Romelli, E., Roncarelli, M., Saglia, R., Sakr, Z., Salvignol, J. -C., Sánchez, A. G., Sapone, D., Sartoris, B., Schirmer, M., Secroun, A., Serrano, S., Sirignano, C., Sirri, G., Stanco, L., Steinwagner, J., Tallada-Crespí, P., Taylor, A. N., Tereno, I., Toledo-Moreo, R., Torradeflot, F., Tutusaus, I., Valenziano, L., Vassallo, T., Kleijn, G. Verdoes, Wang, Y., Weller, J., Zacchei, A., Zamorani, G., Zucca, E., Biviano, A., Bolzonella, M., Bozzo, E., Burigana, C., Calabrese, M., Di Ferdinando, D., Vigo, J. A. Escartin, Finelli, F., Gracia-Carpio, J., Matthew, S., Mauri, N., Pezzotta, A., Pöntinen, M., Porciani, C., Scottez, V., Tenti, M., Viel, M., Wiesmann, M., Akrami, Y., Allevato, V., Anselmi, S., Archidiacono, M., Atrio-Barandela, F., Balaguera-Antolinez, A., Ballardini, M., Bertacca, D., Bethermin, M., Blanchard, A., Blot, L., Böhringer, H., Bruton, S., Cabanac, R., Calabro, A., Cañas-Herrera, G., Cappi, A., Caro, F., Carvalho, C. S., Chambers, K. C., Cooray, A. R., De Caro, B., de la Torre, S., Desprez, G., Díaz-Sánchez, A., Diaz, J. J., Di Domizio, S., Dole, H., Escoffier, S., Ferrari, A. G., Ferreira, P. G., Ferrero, I., Finoguenov, A., Fontana, A., Fornari, F., Gabarra, L., Ganga, K., García-Bellido, J., Gasparetto, T., Gautard, V., Gaztanaga, E., Giacomini, F., Gianotti, F., Gozaliasl, G., Gutierrez, C. M., Hall, A., Hildebrandt, H., Hjorth, J., Muñoz, A. Jimenez, Kajava, J. J. E., Kansal, V., Karagiannis, D., Kirkpatrick, C. C., Brun, A. M. C. Le, Graet, J. Le, Legrand, L., Lesgourgues, J., Liaudat, T. I., Loureiro, A., Maggio, G., Magliocchetti, M., Mannucci, F., Maoli, R., Martins, C. J. A. P., Maurin, L., Metcalf, R. B., Miluzio, M., Montoro, A., Mora, A., Moretti, C., Morgante, G., Nadathur, S., Walton, Nicholas A., Pagano, L., Patrizii, L., Popa, V., Potter, D., Risso, I., Rocci, P. -F., Sahlén, M., Sarpa, E., Schneider, A., Sereno, M., Mancini, A. Spurio, Stadel, J., Tanidis, K., Tao, C., Tessore, N., Testera, G., Teyssier, R., Toft, S., Tosi, S., Troja, A., Tucci, M., Valieri, C., Valiviita, J., Vergani, D., Verza, G., and Vielzeuf, P.

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

The Euclid mission, designed to map the geometry of the dark Universe, presents an unprecedented opportunity for advancing our understanding of the cosmos through its photometric galaxy cluster survey. This paper focuses on enhancing the precision of halo bias (HB) predictions, which is crucial for deriving cosmological constraints from the clustering of galaxy clusters. Our study is based on the peak-background split (PBS) model linked to the halo mass function (HMF); it extends with a parametric correction to precisely align with results from an extended set of $N$-body simulations carried out with the OpenGADGET3 code. Employing simulations with fixed and paired initial conditions, we meticulously analyze the matter-halo cross-spectrum and model its covariance using a large number of mock catalogs generated with Lagrangian Perturbation Theory simulations with the PINOCCHIO code. This ensures a comprehensive understanding of the uncertainties in our HB calibration. Our findings indicate that the calibrated HB model is remarkably resilient against changes in cosmological parameters including those involving massive neutrinos. The robustness and adaptability of our calibrated HB model provide an important contribution to the cosmological exploitation of the cluster surveys to be provided by the Euclid mission. This study highlights the necessity of continuously refining the calibration of cosmological tools like the HB to match the advancing quality of observational data. As we project the impact of our model on cosmological constraints, we find that, given the sensitivity of the Euclid survey, a miscalibration of the HB could introduce biases in cluster cosmology analyses. Our work fills this critical gap, ensuring the HB calibration matches the expected precision of the Euclid survey. The implementation of our model is publicly available in https://github.com/TiagoBsCastro/CCToolkit., Comment: 20 pages; 12 figures; accepted for publication in A&A; abstract abridged for arXiv submission

Published
2024
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3. The Hodge filtration and parametrically prime divisors

Author

Bath, Daniel and Dakin, Henry

Subjects
Mathematics - Algebraic Geometry, Mathematics - Commutative Algebra, Primary 14J17, 32S35 Secondary: 14F17, 14F10, 32C38, 32S40
Abstract

We study the canonical Hodge filtration on the sheaf $\mathscr{O}_X(*D)$ of meromorphic functions along a divisor. For a germ of an analytic function $f$ whose Bernstein-Sato's polynomial's roots are contained in $(-2,0)$, we: give a simple algebraic formula for the zeroeth piece of the Hodge filtration; bound the first step of the Hodge filtration containing $f^{-1}$. If we additionally require $f$ to be Euler homogeneous and parametrically prime, then we extend our algebraic formula to compute every piece of the canonical Hodge filtration, proving in turn that the Hodge filtration is contained in the induced order filtration. Finally, we compute the Hodge filtration in many examples and identify several large classes of divisors realizing our theorems., Comment: Comments welcome

Published
2024

4. Efficacy and safety of fasinumab in an NSAID-controlled study in patients with pain due to osteoarthritis of the knee or hip

Author

Stephen J. DiMartino, Haitao Gao, Simon Eng, Guillermo Valenzuela, Thomas Fuerst, Chetachi Emeremni, Tina Ho, Hazem E. Hassan, Kenneth C. Turner, John D. Davis, Souhil Zaim, Jesse Chao, Yamini Patel, Lillian Brener, Ngan Trinh, Garen Manvelian, Michael Fetell, Ned Braunstein, Gregory P. Geba, and Paula Dakin

Subjects
Fasinumab, NGF inhibitor, NSAID, Osteoarthritis, Pain, Diseases of the musculoskeletal system, RC925-935
Abstract

Abstract Objective Osteoarthritis (OA) causes significant musculoskeletal pain. This study assessed the efficacy and safety of fasinumab, an investigational nerve growth factor inhibitor, in patients with moderate-to-severe OA pain of the knee/hip. Methods In this Phase 3, randomized, double-blind, placebo- and non-steroidal anti-inflammatory drug (NSAID)-controlled study, patients with OA (Kellgren-Lawrence grade ≥ 2; Western Ontario and McMaster Universities Arthritis Index [WOMAC] pain score ≥ 4) received (2:1:1:1) fasinumab 1 mg every 4 weeks, diclofenac 75 mg twice daily, celecoxib 200 mg daily, or placebo for 24 weeks. Co‑primary endpoints were change in WOMAC pain and physical function scores to Week 24 versus placebo. For safety, joints were imaged in all patients at pre‑specified times, regardless of symptoms. Results Of 4531 patients screened, 1650 were randomized. At Week 24, greater improvements were observed for fasinumab versus placebo; least-squares mean difference: –0.63 (p = 0.0003) for WOMAC pain and –0.64 (p = 0.0003) for physical function. Improvements were numerically greater for fasinumab versus NSAIDs for physical function (–0.64 versus –0.31; nominal p

Published
2025
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5. Small molecule APOL1 inhibitors as a precision medicine approach for APOL1-mediated kidney disease

Author

Brandon Zimmerman, Leslie A. Dakin, Anne Fortier, Evanthia Nanou, Angelo Blasio, James Mann, Howard Miller, Marissa Fletcher, Tiansheng Wang, Suganthini Nanthakumar, Gizelle McCarthy, Caline Matar, Prachi Matsye, Guanyu Wang, Phillip Snyder, Kevin Daniel, Harsha Swamy, Kelly Sullivan, Franklin Bright, Audrey Powers, Kevin J. Gagnon, Fan Lu, Steven Paula, Suvarna Khare-Pandit, Larry Henry, Martine Hamel, Francois Denis, Olivier Nicolas, Niresh Hariparsad, Shyamesh Kumar, Jennifer Proctor, Timothy Senter, Brinley Furey, and Mark E. Bunnage

Subjects
Science
Abstract

Abstract Chronic kidney disease affects ~10% of people worldwide and there are no disease modifying therapeutics that address the underlying cause of any form of kidney disease. Genome wide association studies have identified the G1 and G2 variants in the apolipoprotein L1 (APOL1) gene as major contributors to a subtype of proteinuric kidney disease now referred to as APOL1-mediated kidney disease (AMKD). We hypothesized that inhibition of APOL1 could have therapeutic potential for this genetically-defined form of kidney disease. Here we describe the development of preclinical assays and the discovery of potent and specific APOL1 inhibitors with drug-like properties. We provide evidence that APOL1 channel activity drives podocyte injury and that inhibition of this activity stops APOL1-mediated cell death and kidney damage in a transgenic mouse model. These preclinical data, combined with clinical data from our previously published phase 2 proof-of-concept study, support the potential of APOL1 channel inhibition for the treatment of AMKD.

Published
2025
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6. Pharmacological treatment in autism: a proposal for guidelines on common co-occurring psychiatric symptoms

Author

Mariah A. Manter, Kirstin B. Birtwell, James Bath, Nora D. B. Friedman, Christopher J. Keary, Ann M. Neumeyer, Michelle L. Palumbo, Robyn P. Thom, Emily Stonestreet, Hannah Brooks, Kelly Dakin, Jacob M. Hooker, and Christopher J. McDougle

Subjects
Autism, Psychopharmacology, Autism-competent care, Guidelines, Primary care, Sleep, Medicine
Abstract

Abstract Background The prevalence of autism spectrum disorder (ASD) has surged, with an estimated 1 in 36 eight-year-olds in the United States meeting criteria for ASD in 2020. Autistic individuals face elevated rates of co-occurring medical, psychiatric, and behavioral conditions compared to non-autistic individuals. The rising ASD-patient demand is increasingly outpacing the capacity of ASD-specialty clinics, resulting in urgent need for autism-competent providers in general practice settings. This work aims to empower healthcare providers, especially primary care providers (PCPs), with guidelines for the recognition and safe pharmacologic management of common co-occurring psychiatric and behavioral conditions in ASD. Methods Lurie Center for Autism medical providers, who have extensive experience in ASD care, delineated approaches for recognition and pharmacological treatment of sleep disturbances, attention-deficit/hyperactivity disorder (ADHD), anxiety, depression, and irritability tailored to ASD patients. Pharmacological guidelines were iteratively refined until consensus was reached. Treatment differences relative to standard of care (SOC) of non-autistic individuals are noted. Key literature and clinical trial results were reviewed to supplement clinical experience. Results The pharmacological treatment pathways reflect how appropriate medication options for ASD patients can depend on many factors unique to the patient and can differ from established non-autistic SOC. Key takeaways include: For sleep disturbances in ASD, initial strategies align with non-autistic SOC, emphasizing sleep hygiene and melatonin use. First-line recommendations for treating ADHD, anxiety, and depression in ASD differ from non-autistic SOC; α2-adrenergic agonists are more suitable than stimulants for some ASD-ADHD patients, buspirone and mirtazapine are preferred to selective serotonin reuptake inhibitors (SSRIs) for anxiety, and duloxetine, mirtazapine, bupropion, and vortioxetine are recommended ahead of SSRIs for depression. Addressing irritability in ASD requires interdisciplinary evaluation of contributing factors, and guanfacine, risperidone, or aripiprazole may be appropriate, depending on severity. Conclusions Recognition and treatment of co-occurring psychiatric and behavioral conditions in autistic patients must account for differences in clinical presentation and medication effectiveness and tolerability. Drawing on evidence-based clinical insights, these guidelines seek to support PCPs in making informed decisions when prescribing medications for ASD patients with co-occurring psychiatric and behavioral conditions, ultimately enhancing access to timely, comprehensive care for all individuals with ASD.

Published
2025
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7. PROSPECT: A profile likelihood code for frequentist cosmological parameter inference

Author

Holm, Emil Brinch, Nygaard, Andreas, Dakin, Jeppe, Hannestad, Steen, and Tram, Thomas

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics, High Energy Physics - Phenomenology
Abstract

Cosmological parameter inference has been dominated by the Bayesian approach for the past two decades, primarily due to its computational efficiency. However, the Bayesian approach involves integration of the posterior probability and therefore depends on both the choice of model parametrisation and the choice of prior on the model parameter space. In some cases, this can lead to conclusions which are driven by choice of parametrisation and priors rather than by data. The profile likelihood method provides a complementary frequentist tool which can be used to investigate this effect. In this paper, we present the code PROSPECT for computing profile likelihoods in cosmology. We showcase the code using a phenomenological model for converting dark matter into dark radiation that suffers from large volume effects and prior dependence. PROSPECT is compatible with both cobaya and MontePython, and is publicly available at https://github.com/AarhusCosmology/prospect_public., Comment: 27 pages, 9 figures; v3: matches version accepted for publication

Published
2023

8. Euclid preparation. XXXIX. The effect of baryons on the Halo Mass Function

Author

Euclid Collaboration, Castro, T., Borgani, S., Costanzi, M., Dakin, J., Dolag, K., Fumagalli, A., Ragagnin, A., Saro, A., Brun, A. M. C. Le, Aghanim, N., Amara, A., Andreon, S., Auricchio, N., Baldi, M., Bardelli, S., Bodendorf, C., Bonino, D., Branchini, E., Brescia, M., Brinchmann, J., Camera, S., Capobianco, V., Carbone, C., Carretero, J., Casas, S., Castellano, M., Cavuoti, S., Cimatti, A., Congedo, G., Conselice, C. J., Conversi, L., Copin, Y., Corcione, L., Courbin, F., Courtois, H. M., Cropper, M., Da Silva, A., Degaudenzi, H., Di Giorgio, A. M., Dinis, J., Dubath, F., Duncan, C. A. J., Dupac, X., Farina, M., Farrens, S., Ferriol, S., Frailis, M., Franceschi, E., Fumana, M., Galeotta, S., Gillis, B., Giocoli, C., Grazian, A., Grupp, F., Haugan, S. V. H., Holmes, W., Hormuth, F., Hornstrup, A., Jahnke, K., Keihänen, E., Kermiche, S., Kiessling, A., Kilbinger, M., Kubik, B., Kunz, M., Kurki-Suonio, H., Ligori, S., Lilje, P. B., Lindholm, V., Lloro, I., Maiorano, E., Mansutti, O., Marggraf, O., Markovic, K., Martinet, N., Marulli, F., Massey, R., Maurogordato, S., Medinaceli, E., Meneghetti, M., Merlin, E., Meylan, G., Moresco, M., Moscardini, L., Munari, E., Niemi, S. -M., Padilla, C., Paltani, S., Pasian, F., Pettorino, V., Pires, S., Polenta, G., Poncet, M., Popa, L. A., Pozzetti, L., Raison, F., Rebolo, R., Renzi, A., Rhodes, J., Riccio, G., Romelli, E., Roncarelli, M., Saglia, R., Sapone, D., Sartoris, B., Schneider, P., Schrabback, T., Secroun, A., Seidel, G., Serrano, S., Sirignano, C., Sirri, G., Stanco, L., Starck, J. -L., Tallada-Crespí, P., Taylor, A. N., Tereno, I., Toledo-Moreo, R., Torradeflot, F., Tutusaus, I., Valentijn, E. A., Valenziano, L., Vassallo, T., Veropalumbo, A., Wang, Y., Weller, J., Zacchei, A., Zamorani, G., Zoubian, J., Zucca, E., Biviano, A., Bozzo, E., Cerna, C., Colodro-Conde, C., Di Ferdinando, D., Mauri, N., Neissner, C., Sakr, Z., Scottez, V., Tenti, M., Viel, M., Wiesmann, M., Akrami, Y., Anselmi, S., Baccigalupi, C., Ballardini, M., Borlaff, A. S., Bruton, S., Burigana, C., Cabanac, R., Cappi, A., Carvalho, C. S., Castignani, G., Cañas-Herrera, G., Chambers, K. C., Cooray, A. R., Coupon, J., Cucciati, O., Díaz-Sánchez, A., Davini, S., de la Torre, S., De Lucia, G., Desprez, G., Di Domizio, S., Dole, H., Escoffier, S., Ferrero, I., Finelli, F., Gabarra, L., Ganga, K., Garcia-Bellido, J., Giacomini, F., Gozaliasl, G., Hildebrandt, H., Ilić, S., Munñoz, A. Jimanez, Kajava, J. J. E., Kansal, V., Kirkpatrick, C. C., Legrand, L., Loureiro, A., Macias-Perez, J., Magliocchetti, M., Mainetti, G., Maoli, R., Martinelli, M., Martins, C. J. A. P., Matthew, S., Maturi, M., Maurin, L., Metcalf, R. B., Migliaccio, M., Monaco, P., Morgante, G., Nadathur, S., Patrizii, L., Pezzotta, A., Popa, V., Porciani, C., Potter, D., Pöntinen, M., Reimberg, P., Rocci, P. -F., Sánchez, A. G., Schaye, J., Schneider, A., Sefusatti, E., Sereno, M., Simon, P., Mancini, A. Spurio, Stadel, J., Stanford, S. A., Steinwagner, J., Testera, G., Tewes, M., Teyssier, R., Toft, S., Tosi, S., Troja, A., Tucci, M., Valiviita, J., and Vergani, D.

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

The Euclid photometric survey of galaxy clusters stands as a powerful cosmological tool, with the capacity to significantly propel our understanding of the Universe. Despite being sub-dominant to dark matter and dark energy, the baryonic component in our Universe holds substantial influence over the structure and mass of galaxy clusters. This paper presents a novel model to precisely quantify the impact of baryons on galaxy cluster virial halo masses, using the baryon fraction within a cluster as proxy for their effect. Constructed on the premise of quasi-adiabaticity, the model includes two parameters calibrated using non-radiative cosmological hydrodynamical simulations and a single large-scale simulation from the Magneticum set, which includes the physical processes driving galaxy formation. As a main result of our analysis, we demonstrate that this model delivers a remarkable one percent relative accuracy in determining the virial dark matter-only equivalent mass of galaxy clusters, starting from the corresponding total cluster mass and baryon fraction measured in hydrodynamical simulations. Furthermore, we demonstrate that this result is robust against changes in cosmological parameters and against varying the numerical implementation of the sub-resolution physical processes included in the simulations. Our work substantiates previous claims about the impact of baryons on cluster cosmology studies. In particular, we show how neglecting these effects would lead to biased cosmological constraints for a Euclid-like cluster abundance analysis. Importantly, we demonstrate that uncertainties associated with our model, arising from baryonic corrections to cluster masses, are sub-dominant when compared to the precision with which mass-observable relations will be calibrated using Euclid, as well as our current understanding of the baryon fraction within galaxy clusters., Comment: 18 pages, 10 figures, 4 tables, 1 appendix, abstract abridged for arXiv submission; v2 matches published version

Published
2023

9. The Inherent Violence of Anti-Black Racism and its Effects on HIV Care for Black Sexually Minoritized Men

Author

Quinn, Katherine G, Walsh, Jennifer L, DiFranceisco, Wayne, Edwards, Travonne, Takahashi, Lois, Johnson, Anthony, Dakin, Andrea, Bouacha, Nora, and Voisin, Dexter R

Subjects
Public Health, Health Sciences, Sexually Transmitted Infections, Infectious Diseases, Social Determinants of Health, Clinical Research, Mental Health, Prevention, Depression, Mental Illness, HIV/AIDS, Brain Disorders, Behavioral and Social Science, Infection, Good Health and Well Being, Male, Humans, Racism, HIV Infections, Black or African American, Cross-Sectional Studies, Sexual Behavior, HIV, Black MSM, Community support, ART adherence, Structural violence, Engagement in care, Human Movement and Sports Sciences, Public Health and Health Services, Public health
Abstract

The goal of this study was to examine the effects of racial discrimination, depression, and Black LGBTQ community support on HIV care outcomes among a sample of Black sexually minoritized men living with HIV. We conducted a cross-sectional survey with 107 Black sexually minoritized men living with HIV in Chicago. A path model was used to test associations between racial discrimination, Black LGBTQ community support, depressive symptoms, and missed antiretroviral medication doses and HIV care appointments. Results of the path model showed that men who had experienced more racism had more depressive symptoms and subsequently, missed more doses of HIV antiretroviral medication and had missed more HIV care appointments. Greater Black LGBTQ community support was associated with fewer missed HIV care appointments in the past year. This research shows that anti-Black racism may be a pervasive and harmful determinant of HIV inequities and a critical driver of racial disparities in ART adherence and HIV care engagement experienced by Black SMM. Black LGBTQ community support may buffer against the effects of racial discrimination on HIV care outcomes by providing safe, inclusive, supportive spaces for Black SMM.

Published
2024

10. Navigating the Predictive Landscape: DiaRem’s Role in Unveiling Outcomes for Diabetes Remission following ESG

Author

Lahooti, Ali, Rizvi, Anam, Canakis, Andrew, Akagbosu, Cynthia, Johnson, Kate E., Hassan, Kamal, Lahooti, Ila, Abu-Hammour, Mohamed, Dawod, Enad, Dawod, Qais, Newberry, Carolyn, Sampath, Kartik, Carr-Locke, David, Mahadev, SriHari, Afaneh, Cheguevara, Dakin, Gregory, Kumar, Sonal, Yeung, Michele, Barenbaum, Sarah, Tchang, Beverly, Shukla, Alpana P., Aronne, Louis J., and Sharaiha, Reem Z.

Published
2024
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13. A hybrid type II effectiveness-implementation trial of a positive emotion regulation intervention among people living with HIV engaged in Ryan White Medical Case Management: protocol and design for the ORCHID study

Author

Xavier Hall, Casey D., Ethier, Kristen, Cummings, Peter, Freeman, Angela, Bovbjerg, Katrin, Bannon, Jacqueline, Dakin, Andrea, Abujado, Fay, Bouacha, Nora, Derricotte, Devan, Patterson, Lakethia, Hirschhorn, Lisa R., Bouris, Alida, and Moskowitz, Judith T.

Published
2024
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15. Co-aggregation with Apolipoprotein E modulates the function of Amyloid-β in Alzheimer’s disease

Author

Xia, Zengjie, Prescott, Emily E., Urbanek, Agnieszka, Wareing, Hollie E., King, Marianne C., Olerinyova, Anna, Dakin, Helen, Leah, Tom, Barnes, Katy A., Matuszyk, Martyna M., Dimou, Eleni, Hidari, Eric, Zhang, Yu P., Lam, Jeff Y. L., Danial, John S. H., Strickland, Michael R., Jiang, Hong, Thornton, Peter, Crowther, Damian C., Ohtonen, Sohvi, Gómez-Budia, Mireia, Bell, Simon M., Ferraiuolo, Laura, Mortiboys, Heather, Higginbottom, Adrian, Wharton, Stephen B., Holtzman, David M., Malm, Tarja, Ranasinghe, Rohan T., Klenerman, David, and De, Suman

Published
2024
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17. A single cell atlas of frozen shoulder capsule identifies features associated with inflammatory fibrosis resolution

Author

Ng, Michael T. H., Borst, Rowie, Gacaferi, Hamez, Davidson, Sarah, Ackerman, Jessica E., Johnson, Peter A., Machado, Caio C., Reekie, Ian, Attar, Moustafa, Windell, Dylan, Kurowska-Stolarska, Mariola, MacDonald, Lucy, Alivernini, Stefano, Garvilles, Micon, Jansen, Kathrin, Bhalla, Ananya, Lee, Angela, Charlesworth, James, Chowdhury, Rajat, Klenerman, Paul, Powell, Kate, Hackstein, Carl-Philip, Furniss, Dominic, Rees, Jonathan, Gilroy, Derek, Coles, Mark, Carr, Andrew J., Sansom, Stephen N., Buckley, Christopher D., and Dakin, Stephanie G.

Published
2024
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19. Understanding the impact of police brutality on Black sexually minoritized men

Author

Quinn, Katherine G, Edwards, Travonne, Johnson, Anthony, Takahashi, Lois, Dakin, Andrea, Bouacha, Nora, and Voisin, Dexter

Subjects
Criminology, Human Society, Mental Health, Violence Research, Social Determinants of Health, Behavioral and Social Science, 2.3 Psychological, social and economic factors, Mental health, Good Health and Well Being, Peace, Justice and Strong Institutions, Humans, Male, Anxiety, Black People, Emotions, Police, Sexual and Gender Minorities, Adolescent, Young Adult, Adult, Violence, Trust, Safety, Black gay and bisexual men, Police violence, Police brutality, Trauma, Medical and Health Sciences, Economics, Studies in Human Society, Public Health, Health sciences, Human society
Abstract

Young Black gay, bisexual, and other sexually minoritized men (SMM) face high levels of police brutality and other negative, unwarranted encounters with the police. Such interactions have known health consequences. The purpose of this study was to understand the health, mental health, and social consequences of police brutality experienced by young Black SMM. We conducted in-depth interviews with 31 Black, cisgender men, ages of 16-30 and analyzed the data using thematic analysis. Our primary results are summarized in four themes: 1) Police brutality is built into the system and diminishes trust; 2) Videos and social media make visible violence that has long existed; 3) Police brutality contributes to anxiety and other psychosocial effects; and 4) Violence reduces feelings of safety and contributes to avoidance of police. Our results highlight the direct and vicarious police brutality participants are subjected to and sheds light on the effects of such violence on trust, perceived safety, anxiety, and trauma symptoms. Results from this study contribute to the needed public health conversation around police brutality against Black men, specifically shedding light on the experiences of Black SMM.

Published
2023

20. The James Webb Space Telescope Mission

Author

Gardner, Jonathan P., Mather, John C., Abbott, Randy, Abell, James S., Abernathy, Mark, Abney, Faith E., Abraham, John G., Abraham, Roberto, Abul-Huda, Yasin M., Acton, Scott, Adams, Cynthia K., Adams, Evan, Adler, David S., Adriaensen, Maarten, Aguilar, Jonathan Albert, Ahmed, Mansoor, Ahmed, Nasif S., Ahmed, Tanjira, Albat, Rüdeger, Albert, Loïc, Alberts, Stacey, Aldridge, David, Allen, Mary Marsha, Allen, Shaune S., Altenburg, Martin, Altunc, Serhat, Alvarez, Jose Lorenzo, Álvarez-Márquez, Javier, de Oliveira, Catarina Alves, Ambrose, Leslie L., Anandakrishnan, Satya M., Andersen, Gregory C., Anderson, Harry James, Anderson, Jay, Anderson, Kristen, Anderson, Sara M., Aprea, Julio, Archer, Benita J., Arenberg, Jonathan W., Argyriou, Ioannis, Arribas, Santiago, Artigau, Étienne, Arvai, Amanda Rose, Atcheson, Paul, Atkinson, Charles B., Averbukh, Jesse, Aymergen, Cagatay, Bacinski, John J., Baggett, Wayne E., Bagnasco, Giorgio, Baker, Lynn L., Balzano, Vicki Ann, Banks, Kimberly A., Baran, David A., Barker, Elizabeth A., Barrett, Larry K., Barringer, Bruce O., Barto, Allison, Bast, William, Baudoz, Pierre, Baum, Stefi, Beatty, Thomas G., Beaulieu, Mathilde, Bechtold, Kathryn, Beck, Tracy, Beddard, Megan M., Beichman, Charles, Bellagama, Larry, Bely, Pierre, Berger, Timothy W., Bergeron, Louis E., Darveau-Bernier, Antoine, Bertch, Maria D., Beskow, Charlotte, Betz, Laura E., Biagetti, Carl P., Birkmann, Stephan, Bjorklund, Kurt F., Blackwood, James D., Blazek, Ronald Paul, Blossfeld, Stephen, Bluth, Marcel, Boccaletti, Anthony, Boegner Jr., Martin E., Bohlin, Ralph C., Boia, John Joseph, Böker, Torsten, Bonaventura, N., Bond, Nicholas A., Bosley, Kari Ann, Boucarut, Rene A., Bouchet, Patrice, Bouwman, Jeroen, Bower, Gary, Bowers, Ariel S., Bowers, Charles W., Boyce, Leslye A., Boyer, Christine T., Boyer, Martha L., Boyer, Michael, Boyer, Robert, Bradley, Larry D., Brady, Gregory R., Brandl, Bernhard R., Brannen, Judith L., Breda, David, Bremmer, Harold G., Brennan, David, Bresnahan, Pamela A., Bright, Stacey N., Broiles, Brian J., Bromenschenkel, Asa, Brooks, Brian H., Brooks, Keira J., Brown, Bob, Brown, Bruce, Brown, Thomas M., Bruce, Barry W., Bryson, Jonathan G., Bujanda, Edwin D., Bullock, Blake M., Bunker, A. J., Bureo, Rafael, Burt, Irving J., Bush, James Aaron, Bushouse, Howard A., Bussman, Marie C., Cabaud, Olivier, Cale, Steven, Calhoon, Charles D., Calvani, Humberto, Canipe, Alicia M., Caputo, Francis M., Cara, Mihai, Carey, Larkin, Case, Michael Eli, Cesari, Thaddeus, Cetorelli, Lee D., Chance, Don R., Chandler, Lynn, Chaney, Dave, Chapman, George N., Charlot, S., Chayer, Pierre, Cheezum, Jeffrey I., Chen, Bin, Chen, Christine H., Cherinka, Brian, Chichester, Sarah C., Chilton, Zachary S., Chittiraibalan, Dharini, Clampin, Mark, Clark, Charles R., Clark, Kerry W., Clark, Stephanie M., Claybrooks, Edward E., Cleveland, Keith A., Cohen, Andrew L., Cohen, Lester M., Colón, Knicole D., Coleman, Benee L., Colina, Luis, Comber, Brian J., Comeau, Thomas M., Comer, Thomas, Reis, Alain Conde, Connolly, Dennis C., Conroy, Kyle E., Contos, Adam R., Contreras, James, Cook, Neil J., Cooper, James L., Cooper, Rachel Aviva, Correia, Michael F., Correnti, Matteo, Cossou, Christophe, Costanza, Brian F., Coulais, Alain, Cox, Colin R., Coyle, Ray T., Cracraft, Misty M., Noriega-Crespo, Alberto, Crew, Keith A., Curtis, Gary J., Cusveller, Bianca, Maciel, Cleyciane Da Costa, Dailey, Christopher T., Daugeron, Frédéric, Davidson, Greg S., Davies, James E., Davis, Katherine Anne, Davis, Michael S., Day, Ratna, de Chambure, Daniel, de Jong, Pauline, De Marchi, Guido, Dean, Bruce H., Decker, John E., Delisa, Amy S., Dell, Lawrence C., Dellagatta, Gail, Dembinska, Franciszka, Demosthenes, Sandor, Dencheva, Nadezhda M., Deneu, Philippe, DePriest, William W., Deschenes, Jeremy, Dethienne, Nathalie, Detre, Örs Hunor, Diaz, Rosa Izela, Dicken, Daniel, DiFelice, Audrey S., Dillman, Matthew, Disharoon, Maureen O., van Dishoeck, Ewine F., Dixon, William V., Doggett, Jesse B., Dominguez, Keisha L., Donaldson, Thomas S., Doria-Warner, Cristina M., Santos, Tony Dos, Doty, Heather, Douglas Jr., Robert E., Doyon, René, Dressler, Alan, Driggers, Jennifer, Driggers, Phillip A., Dunn, Jamie L., DuPrie, Kimberly C., Dupuis, Jean, Durning, John, Dutta, Sanghamitra B., Earl, Nicholas M., Eccleston, Paul, Ecobichon, Pascal, Egami, Eiichi, Ehrenwinkler, Ralf, Eisenhamer, Jonathan D., Eisenhower, Michael, Eisenstein, Daniel J., Hamel, Zaky El, Elie, Michelle L., Elliott, James, Elliott, Kyle Wesley, Engesser, Michael, Espinoza, Néstor, Etienne, Odessa, Etxaluze, Mireya, Evans, Leah, Fabreguettes, Luce, Falcolini, Massimo, Falini, Patrick R., Fatig, Curtis, Feeney, Matthew, Feinberg, Lee D., Fels, Raymond, Ferdous, Nazma, Ferguson, Henry C., Ferrarese, Laura, Ferreira, Marie-Héléne, Ferruit, Pierre, Ferry, Malcolm, Filippazzo, Joseph Charles, Firre, Daniel, Fix, Mees, Flagey, Nicolas, Flanagan, Kathryn A., Fleming, Scott W., Florian, Michael, Flynn, James R., Foiadelli, Luca, Fontaine, Mark R., Fontanella, Erin Marie, Forshay, Peter Randolph, Fortner, Elizabeth A., Fox, Ori D., Framarini, Alexandro P., Francisco, John I., Franck, Randy, Franx, Marijn, Franz, David E., Friedman, Scott D., Friend, Katheryn E., Frost, James R., Fu, Henry, Fullerton, Alexander W., Gaillard, Lionel, Galkin, Sergey, Gallagher, Ben, Galyer, Anthony D., Marín, Macarena García, Gardner, Lisa E., Garland, Dennis, Garrett, Bruce Albert, Gasman, Danny, Gáspár, András, Gastaud, René, Gaudreau, Daniel, Gauthier, Peter Timothy, Geers, Vincent, Geithner, Paul H., Gennaro, Mario, Gerber, John, Gereau, John C., Giampaoli, Robert, Giardino, Giovanna, Gibbons, Paul C., Gilbert, Karolina, Gilman, Larry, Girard, Julien H., Giuliano, Mark E., Gkountis, Konstantinos, Glasse, Alistair, Glassmire, Kirk Zachary, Glauser, Adrian Michael, Glazer, Stuart D., Goldberg, Joshua, Golimowski, David A., Gonzaga, Shireen P., Gordon, Karl D., Gordon, Shawn J., Goudfrooij, Paul, Gough, Michael J., Graham, Adrian J., Grau, Christopher M., Green, Joel David, Greene, Gretchen R., Greene, Thomas P., Greenfield, Perry E., Greenhouse, Matthew A., Greve, Thomas R., Greville, Edgar M., Grimaldi, Stefano, Groe, Frank E., Groebner, Andrew, Grumm, David M., Grundy, Timothy, Güdel, Manuel, Guillard, Pierre, Guldalian, John, Gunn, Christopher A., Gurule, Anthony, Gutman, Irvin Meyer, Guy, Paul D., Guyot, Benjamin, Hack, Warren J., Haderlein, Peter, Hagan, James B., Hagedorn, Andria, Hainline, Kevin, Haley, Craig, Hami, Maryam, Hamilton, Forrest Clifford, Hammann, Jeffrey, Hammel, Heidi B., Hanley, Christopher J., Hansen, Carl August, Hardy, Bruce, Harnisch, Bernd, Harr, Michael Hunter, Harris, Pamela, Hart, Jessica Ann, Hartig, George F., Hasan, Hashima, Hashim, Kathleen Marie, Hashimoto, Ryan, Haskins, Sujee J., Hawkins, Robert Edward, Hayden, Brian, Hayden, William L., Healy, Mike, Hecht, Karen, Heeg, Vince J., Hejal, Reem, Helm, Kristopher A., Hengemihle, Nicholas J., Henning, Thomas, Henry, Alaina, Henry, Ronald L., Henshaw, Katherine, Hernandez, Scarlin, Herrington, Donald C., Heske, Astrid, Hesman, Brigette Emily, Hickey, David L., Hilbert, Bryan N., Hines, Dean C., Hinz, Michael R., Hirsch, Michael, Hitcho, Robert S., Hodapp, Klaus, Hodge, Philip E., Hoffman, Melissa, Holfeltz, Sherie T., Holler, Bryan Jason, Hoppa, Jennifer Rose, Horner, Scott, Howard, Joseph M., Howard, Richard J., Huber, Jean M., Hunkeler, Joseph S., Hunter, Alexander, Hunter, David Gavin, Hurd, Spencer W., Hurst, Brendan J., Hutchings, John B., Hylan, Jason E., Ignat, Luminita Ilinca, Illingworth, Garth, Irish, Sandra M., Isaacs III, John C., Jackson Jr., Wallace C., Jaffe, Daniel T., Jahic, Jasmin, Jahromi, Amir, Jakobsen, Peter, James, Bryan, James, John C., James, LeAndrea Rae, Jamieson, William Brian, Jandra, Raymond D., Jayawardhana, Ray, Jedrzejewski, Robert, Jeffers, Basil S., Jensen, Peter, Joanne, Egges, Johns, Alan T., Johnson, Carl A., Johnson, Eric L., Johnson, Patricia, Johnson, Phillip Stephen, Johnson, Thomas K., Johnson, Timothy W., Johnstone, Doug, Jollet, Delphine, Jones, Danny P., Jones, Gregory S., Jones, Olivia C., Jones, Ronald A., Jones, Vicki, Jordan, Ian J., Jordan, Margaret E., Jue, Reginald, Jurkowski, Mark H., Justis, Grant, Justtanont, Kay, Kaleida, Catherine C., Kalirai, Jason S., Kalmanson, Phillip Cabrales, Kaltenegger, Lisa, Kammerer, Jens, Kan, Samuel K., Kanarek, Graham Childs, Kao, Shaw-Hong, Karakla, Diane M., Karl, Hermann, Kassin, Susan A., Kauffman, David D., Kavanagh, Patrick, Kelley, Leigh L., Kelly, Douglas M., Kendrew, Sarah, Kennedy, Herbert V., Kenny, Deborah A., Keski-Kuha, Ritva A., Keyes, Charles D., Khan, Ali, Kidwell, Richard C., Kimble, Randy A., King, James S., King, Richard C., Kinzel, Wayne M., Kirk, Jeffrey R., Kirkpatrick, Marc E., Klaassen, Pamela, Klingemann, Lana, Klintworth, Paul U., Knapp, Bryan Adam, Knight, Scott, Knollenberg, Perry J., Knutsen, Daniel Mark, Koehler, Robert, Koekemoer, Anton M., Kofler, Earl T., Kontson, Vicki L., Kovacs, Aiden Rose, Kozhurina-Platais, Vera, Krause, Oliver, Kriss, Gerard A., Krist, John, Kristoffersen, Monica R., Krogel, Claudia, Krueger, Anthony P., Kulp, Bernard A., Kumari, Nimisha, Kwan, Sandy W., Kyprianou, Mark, Labador, Aurora Gadiano, Labiano, Álvaro, Lafrenière, David, Lagage, Pierre-Olivier, Laidler, Victoria G., Laine, Benoit, Laird, Simon, Lajoie, Charles-Philippe, Lallo, Matthew D., Lam, May Yen, LaMassa, Stephanie Marie, Lambros, Scott D., Lampenfield, Richard Joseph, Lander, Matthew Ed, Langston, James Hutton, Larson, Kirsten, Larson, Melora, LaVerghetta, Robert Joseph, Law, David R., Lawrence, Jon F., Lee, David W., Lee, Janice, Lee, Yat-Ning Paul, Leisenring, Jarron, Leveille, Michael Dunlap, Levenson, Nancy A., Levi, Joshua S., Levine, Marie B., Lewis, Dan, Lewis, Jake, Lewis, Nikole, Libralato, Mattia, Lidon, Norbert, Liebrecht, Paula Louisa, Lightsey, Paul, Lilly, Simon, Lim, Frederick C., Lim, Pey Lian, Ling, Sai-Kwong, Link, Lisa J., Link, Miranda Nicole, Lipinski, Jamie L., Liu, XiaoLi, Lo, Amy S., Lobmeyer, Lynette, Logue, Ryan M., Long, Chris A., Long, Douglas R., Long, Ilana D., Long, Knox S., López-Caniego, Marcos, Lotz, Jennifer M., Love-Pruitt, Jennifer M., Lubskiy, Michael, Luers, Edward B., Luetgens, Robert A., Luevano, Annetta J., Lui, Sarah Marie G. Flores, Lund III, James M., Lundquist, Ray A., Lunine, Jonathan, Lützgendorf, Nora, Lynch, Richard J., MacDonald, Alex J., MacDonald, Kenneth, Macias, Matthew J., Macklis, Keith I., Maghami, Peiman, Maharaja, Rishabh Y., Maiolino, Roberto, Makrygiannis, Konstantinos G., Malla, Sunita Giri, Malumuth, Eliot M., Manjavacas, Elena, Marini, Andrea, Marrione, Amanda, Marston, Anthony, Martel, André R, Martin, Didier, Martin, Peter G., Martinez, Kristin L., Maschmann, Marc, Masci, Gregory L., Masetti, Margaret E., Maszkiewicz, Michael, Matthews, Gary, Matuskey, Jacob E., McBrayer, Glen A., McCarthy, Donald W., McCaughrean, Mark J., McClare, Leslie A., McClare, Michael D., McCloskey, John C., McClurg, Taylore D., McCoy, Martin, McElwain, Michael W., McGregor, Roy D., McGuffey, Douglas B., McKay, Andrew G., McKenzie, William K., McLean, Brian, McMaster, Matthew, McNeil, Warren, De Meester, Wim, Mehalick, Kimberly L., Meixner, Margaret, Meléndez, Marcio, Menzel, Michael P., Menzel, Michael T., Merz, Matthew, Mesterharm, David D., Meyer, Michael R., Meyett, Michele L., Meza, Luis E., Midwinter, Calvin, Milam, Stefanie N., Miller, Jay Todd, Miller, William C., Miskey, Cherie L., Misselt, Karl, Mitchell, Eileen P., Mohan, Martin, Montoya, Emily E., Moran, Michael J., Morishita, Takahiro, Moro-Martín, Amaya, Morrison, Debra L., Morrison, Jane, Morse, Ernie C., Moschos, Michael, Moseley, S. H., Mosier, Gary E., Mosner, Peter, Mountain, Matt, Muckenthaler, Jason S., Mueller, Donald G., Mueller, Migo, Muhiem, Daniella, Mühlmann, Prisca, Mullally, Susan Elizabeth, Mullen, Stephanie M., Munger, Alan J, Murphy, Jess, Murray, Katherine T., Muzerolle, James C., Mycroft, Matthew, Myers, Andrew, Myers, Carey R., Myers, Fred Richard R., Myers, Richard, Myrick, Kaila, Nagle IV, Adrian F., Nayak, Omnarayani, Naylor, Bret, Neff, Susan G., Nelan, Edmund P., Nella, John, Nguyen, Duy Tuong, Nguyen, Michael N., Nickson, Bryony, Nidhiry, John Joseph, Niedner, Malcolm B., Nieto-Santisteban, Maria, Nikolov, Nikolay K., Nishisaka, Mary Ann, Nota, Antonella, O'Mara, Robyn C., Oboryshko, Michael, O'Brien, Marcus B., Ochs, William R., Offenberg, Joel D., Ogle, Patrick Michael, Ohl, Raymond G., Olmsted, Joseph Hamden, Osborne, Shannon Barbara, O'Shaughnessy, Brian Patrick, Östlin, Göran, O'Sullivan, Brian, Otor, O. Justin, Ottens, Richard, Ouellette, Nathalie N. -Q., Outlaw, Daria J., Owens, Beverly A., Pacifici, Camilla, Page, James Christophe, Paranilam, James G., Park, Sang, Parrish, Keith A., Paschal, Laura, Patapis, Polychronis, Patel, Jignasha, Patrick, Keith, Pattishall Jr., Robert A., Paul, Douglas William, Paul, Shirley J., Pauly, Tyler Andrew, Pavlovsky, Cheryl M., Peña-Guerrero, Maria, Pedder, Andrew H., Peek, Matthew Weldon, Pelham, Patricia A., Penanen, Konstantin, Perriello, Beth A., Perrin, Marshall D., Perrine, Richard F., Perrygo, Chuck, Peslier, Muriel, Petach, Michael, Peterson, Karla A., Pfarr, Tom, Pierson, James M., Pietraszkiewicz, Martin, Pilchen, Guy, Pipher, Judy L., Pirzkal, Norbert, Pitman, Joseph T., Player, Danielle M., Plesha, Rachel, Plitzke, Anja, Pohner, John A., Poletis, Karyn Konstantin, Pollizzi, Joseph A., Polster, Ethan, Pontius, James T., Pontoppidan, Klaus, Porges, Susana C., Potter, Gregg D., Prescott, Stephen, Proffitt, Charles R., Pueyo, Laurent, Neira, Irma Aracely Quispe, Radich, Armando, Rager, Reiko T., Rameau, Julien, Ramey, Deborah D., Alarcon, Rafael Ramos, Rampini, Riccardo, Rapp, Robert, Rashford, Robert A., Rauscher, Bernard J., Ravindranath, Swara, Rawle, Timothy, Rawlings, Tynika N., Ray, Tom, Regan, Michael W., Rehm, Brian, Rehm, Kenneth D., Reid, Neill, Reis, Carl A., Renk, Florian, Reoch, Tom B., Ressler, Michael, Rest, Armin W., Reynolds, Paul J., Richon, Joel G., Richon, Karen V., Ridgaway, Michael, Riedel, Adric Richard, Rieke, George H., Rieke, Marcia, Rifelli, Richard E., Rigby, Jane R., Riggs, Catherine S., Ringel, Nancy J., Ritchie, Christine E., Rix, Hans-Walter, Robberto, Massimo, Robinson, Michael S., Robinson, Orion, Rock, Frank W., Rodriguez, David R., del Pino, Bruno Rodríguez, Roellig, Thomas, Rohrbach, Scott O., Roman, Anthony J., Romelfanger, Frederick J., Romo Jr., Felipe P., Rosales, Jose J., Rose, Perry, Roteliuk, Anthony F., Roth, Marc N., Rothwell, Braden Quinn, Rouzaud, Sylvain, Rowe, Jason, Rowlands, Neil, Roy, Arpita, Royer, Pierre, Rui, Chunlei, Rumler, Peter, Rumpl, William, Russ, Melissa L., Ryan, Michael B., Ryan, Richard M., Saad, Karl, Sabata, Modhumita, Sabatino, Rick, Sabbi, Elena, Sabelhaus, Phillip A., Sabia, Stephen, Sahu, Kailash C., Saif, Babak N., Salvignol, Jean-Christophe, Samara-Ratna, Piyal, Samuelson, Bridget S., Sanders, Felicia A., Sappington, Bradley, Sargent, B. A., Sauer, Arne, Savadkin, Bruce J., Sawicki, Marcin, Schappell, Tina M., Scheffer, Caroline, Scheithauer, Silvia, Scherer, Ron, Schiff, Conrad, Schlawin, Everett, Schmeitzky, Olivier, Schmitz, Tyler S., Schmude, Donald J., Schneider, Analyn, Schreiber, Jürgen, Schroeven-Deceuninck, Hilde, Schultz, John J., Schwab, Ryan, Schwartz, Curtis H., Scoccimarro, Dario, Scott, John F., Scott, Michelle B., Seaton, Bonita L., Seely, Bruce S., Seery, Bernard, Seidleck, Mark, Sembach, Kenneth, Shanahan, Clare Elizabeth, Shaughnessy, Bryan, Shaw, Richard A., Shay, Christopher Michael, Sheehan, Even, Sheth, Kartik, Shih, Hsin-Yi, Shivaei, Irene, Siegel, Noah, Sienkiewicz, Matthew G., Simmons, Debra D., Simon, Bernard P., Sirianni, Marco, Sivaramakrishnan, Anand, Slade, Jeffrey E., Sloan, G. C., Slocum, Christine E., Slowinski, Steven E., Smith, Corbett T., Smith, Eric P., Smith, Erin C., Smith, Koby, Smith, Robert, Smith, Stephanie J., Smolik, John L., Soderblom, David R., Sohn, Sangmo Tony, Sokol, Jeff, Sonneborn, George, Sontag, Christopher D., Sooy, Peter R., Soummer, Remi, Southwood, Dana M., Spain, Kay, Sparmo, Joseph, Speer, David T., Spencer, Richard, Sprofera, Joseph D., Stallcup, Scott S., Stanley, Marcia K., Stansberry, John A., Stark, Christopher C., Starr, Carl W., Stassi, Diane Y., Steck, Jane A., Steeley, Christine D., Stephens, Matthew A., Stephenson, Ralph J., Stewart, Alphonso C., Stiavelli, Massimo, Stockman Jr., Hervey, Strada, Paolo, Straughn, Amber N., Streetman, Scott, Strickland, David Kendal, Strobele, Jingping F., Stuhlinger, Martin, Stys, Jeffrey Edward, Such, Miguel, Sukhatme, Kalyani, Sullivan, Joseph F., Sullivan, Pamela C., Sumner, Sandra M., Sun, Fengwu, Sunnquist, Benjamin Dale, Swade, Daryl Allen, Swam, Michael S., Swenton, Diane F., Swoish, Robby A., Litten, Oi In Tam, Tamas, Laszlo, Tao, Andrew, Taylor, David K., Taylor, Joanna M., Plate, Maurice te, Van Tea, Mason, Teague, Kelly K., Telfer, Randal C., Temim, Tea, Texter, Scott C., Thatte, Deepashri G., Thompson, Christopher Lee, Thompson, Linda M., Thomson, Shaun R., Thronson, Harley, Tierney, C. M., Tikkanen, Tuomo, Tinnin, Lee, Tippet, William Thomas, Todd, Connor William, Tran, Hien D., Trauger, John, Trejo, Edwin Gregorio, Truong, Justin Hoang Vinh, Tsukamoto, Christine L., Tufail, Yasir, Tumlinson, Jason, Tustain, Samuel, Tyra, Harrison, Ubeda, Leonardo, Underwood, Kelli, Uzzo, Michael A., Vaclavik, Steven, Valenduc, Frida, Valenti, Jeff A., Van Campen, Julie, van de Wetering, Inge, Van Der Marel, Roeland P., van Haarlem, Remy, Vandenbussche, Bart, Vanterpool, Dona D., Vernoy, Michael R., Costas, Maria Begoña Vila, Volk, Kevin, Voorzaat, Piet, Voyton, Mark F., Vydra, Ekaterina, Waddy, Darryl J., Waelkens, Christoffel, Wahlgren, Glenn Michael, Walker Jr., Frederick E., Wander, Michel, Warfield, Christine K., Warner, Gerald, Wasiak, Francis C., Wasiak, Matthew F., Wehner, James, Weiler, Kevin R., Weilert, Mark, Weiss, Stanley B., Wells, Martyn, Welty, Alan D., Wheate, Lauren, Wheeler, Thomas P., White, Christy L., Whitehouse, Paul, Whiteleather, Jennifer Margaret, Whitman, William Russell, Williams, Christina C., Willmer, Christopher N. A., Willott, Chris J., Willoughby, Scott P., Wilson, Andrew, Wilson, Debra, Wilson, Donna V., Windhorst, Rogier, Wislowski, Emily Christine, Wolfe, David J., Wolfe, Michael A., Wolff, Schuyler, Wondel, Amancio, Woo, Cindy, Woods, Robert T., Worden, Elaine, Workman, William, Wright, Gillian S., Wu, Carl, Wu, Chi-Rai, Wun, Dakin D., Wymer, Kristen B., Yadetie, Thomas, Yan, Isabelle C., Yang, Keith C., Yates, Kayla L., Yeager, Christopher R., Yerger, Ethan John, Young, Erick T., Young, Gary, Yu, Gene, Yu, Susan, Zak, Dean S., Zeidler, Peter, Zepp, Robert, Zhou, Julia, Zincke, Christian A., Zonak, Stephanie, and Zondag, Elisabeth

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

Twenty-six years ago a small committee report, building on earlier studies, expounded a compelling and poetic vision for the future of astronomy, calling for an infrared-optimized space telescope with an aperture of at least $4m$. With the support of their governments in the US, Europe, and Canada, 20,000 people realized that vision as the $6.5m$ James Webb Space Telescope. A generation of astronomers will celebrate their accomplishments for the life of the mission, potentially as long as 20 years, and beyond. This report and the scientific discoveries that follow are extended thank-you notes to the 20,000 team members. The telescope is working perfectly, with much better image quality than expected. In this and accompanying papers, we give a brief history, describe the observatory, outline its objectives and current observing program, and discuss the inventions and people who made it possible. We cite detailed reports on the design and the measured performance on orbit., Comment: Accepted by PASP for the special issue on The James Webb Space Telescope Overview, 29 pages, 4 figures

Published
2023
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21. International healthcare workers' experiences and perceptions of the 2022 multi-country mpox outbreak.

Author

Vanessa Apea, Boghuma K Titanji, Francesca H Dakin, Rosalie Hayes, Melanie Smuk, Habiba Kawu, Laura Waters, Itsik Levy, Daniel R Kuritzkes, Monica Gandhi, Jürgen Rockstroh, Mauro Schechter, Martin Holt, Romain Palich, Claudia P Cortes, Silvia Nozza, Cristina Mussini, Alexandra Calmy, Brenda E Crabtree-Ramirez, José L Blanco, Sanjay Bhagani, Claire Dewsnap, Chloe Orkin, and Mpox SHARE-NET Writing Group

Subjects
Public aspects of medicine, RA1-1270
Abstract

In May 2022, the most widespread outbreak of sustained transmission of mpox outside of countries historically affected countries in Western and Central Africa occurred. We aimed to examine the personal and clinical experiences of international healthcare workers (HCWs) during this public health emergency. We conducted an international cross-sectional survey study between August and October 2022, examining the experiences and perceptions of HCWs clinically involved in the 2022 mpox response. Respondents were recruited via an international network of sexual health and HIV clinicians responding to mpox and promoted through clinical associations and social media. Survey domains included: clinical workload; preparedness; training and support at work; psychological well-being and vaccination. 725 multi-national healthcare workers across 41 countries were included in the analysis. 91% were physicians specialised in Sexual Health or Infectious Diseases; with 34% (n = 247) of all respondents involved in mpox policy. A substantial proportion of respondents (n = 296, 41%) reported working longer hours during the mpox outbreak, with no concomitant removal of other clinical responsibilities. 30% (n = 218) of respondents reported that they had never heard of mpox before the outbreak and over 25% of the respondents reported that they had misdiagnosed someone initially. This culminated in a high prevalence of moral distress at thirty percent. Less than 9% of HCWs in the region of the Caribbean, Central America and South America had been offered a vaccine as compared to almost one-third in the other regions. Where offered, there were high levels of uptake across all regions. The findings highlight a critical need for addressing the profound gaps in HCW knowledge about re-emerging diseases with pandemic potential. Strengthening the resilience of global health systems and prioritising internationally coordinated approaches to global vaccine deployment is imperative.

Published
2025
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22. Interstep Variations of Stairways and Associations of High-Contrast Striping and Fall-Related Events: Observational Study

Author

Sara A Harper, Chayston Brown, Shandon L Poulsen, Tyson S Barrett, and Christopher J Dakin

Subjects
Computer applications to medicine. Medical informatics, R858-859.7, Medical technology, R855-855.5
Abstract

BackgroundInterstep variations in step riser height and tread depth within a stairway could negatively impact safe stair negotiation by decreasing step riser height predictability and, consequently, increasing stair users’ fall risk. Unfortunately, interstep variations in riser height and depth are common, particularly in older stairways, but its impact may be lessened by highlighting steps’ edges using a high-contrast stripe on the top front edge of each step. ObjectiveThis study aimed to determine (1) if fall-related events are associated with greater interstep riser height and depth variations and (2) if such fall-related events are reduced in the presence of contrast-enhanced step edges compared with a control stairway. MethodsStair users were video recorded on 2 public stairways in a university building. One stairway had black vinyl stripes applied to the step’s edges and black-and-white vertical stripes on the last and top steps’ faces. The stairway with striping was counterbalanced, with the striped stairway than a control, and the control with stripes. Each stair user recorded was coded for whether they experienced a fall-related event. A total of 10,000 samples (observations) of 20 fall-related events were drawn with 0.25 probability from each condition to determine the probability of observing a distribution with the constraints outlined by the hypotheses by a computerized Monte Carlo simulation. ResultsIn total, 11,137 individual stair user observations had 20 fall-related events. The flights that had 14 mm in interstep riser height variation and 38 mm in interstep depth variation were associated with 80% (16/20) of the fall-related events observed. Furthermore, 2 fall-related events were observed for low interstep variation with no striping, and 2 fall-related events were observed during low interstep variation with striping. A total of 20 fall-related events were observed, with 4 occurring on flights of stairs with low interstep variation. For stairs with high variability in step dimensions, 13 of 16 (81%) fall-related events occurred on the control stairway (no striping) compared with 3 of 16 (19%) on the high-contrast striping stairway. The distribution of fall-related events we observed between conditions likely did not occur by chance, with a probability of 0.04. ConclusionsThese data support the premise that a vision-based strategy (ie, striping) may counteract fall risk associated with interstep riser height and tread depth variation. Possibly, perception and action elicited through the horizontal-vertical illusion (striping) may have a positive impact on the incidence of fall-related events in the presence of high interstep riser height and depth variation. The findings of this study suggest that contrast enhancement (ie, striping) may be a simple and effective way to reduce the risk of falls associated with interstep variation, highlighting the potential for this approach to make a significant impact on fall prevention efforts.

Published
2025
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23. The Fight is Two Times as Hard: A Qualitative Examination of a Violence Syndemic Among Young Black Sexual Minority Men.

Author

Dakin, Andrea, Bouacha, Nora, Valadez-Tapia, Silvia, Voisin, Dexter, Quinn, Katherine, Edwards, Travonne, Johnson, Anthony, Spector, Antoinette, and Takahashi, Lois

Subjects
Black gay and bisexual men, HIV, intersectionality, mental health, neighborhood violence, Male, Humans, Homosexuality, Male, Sexual and Gender Minorities, Syndemic, Violence, HIV Infections
Abstract

Young Black men who have sex with men (YBMSM) are disproportionately impacted by violence, including violence rooted in anti-Black racism, sexual identity bullying, and neighborhood violence rooted in structural racism and inequities. These multiple forms of violence are frequently co-occurring and interactive creating syndemic conditions that can negatively impact HIV care. This qualitative study is based on in-depth interviews with 31 YBMSM, aged 16-30 years, living with HIV in Chicago, IL, to examine how violence has impacted their lives. Using thematic analysis, we identified five themes that reflect how YBMSM experience violence at the intersection of racism, homonegativity, socioeconomic status, and HIV status: (a) the experience of intersectional violence; (b) long histories of violence contributed to hypervigilance, lack of safety, and lack of trust; (c) making meaning of violence and the importance of strength; (d) normalizing violence for survival; and (e) the cyclical nature of violence. Our study highlights how multiple forms of violence can accumulate across an individuals life and contribute to social and contextual situations that further contribute to violence and negatively impact mental health and HIV care.

Published
2023

26. Euclid: Modelling massive neutrinos in cosmology -- a code comparison

Author

Adamek, J., Angulo, R. E., Arnold, C., Baldi, M., Biagetti, M., Bose, B., Carbone, C., Castro, T., Dakin, J., Dolag, K., Elbers, W., Fidler, C., Giocoli, C., Hannestad, S., Hassani, F., Hernández-Aguayo, C., Koyama, K., Li, B., Mauland, R., Monaco, P., Moretti, C., Mota, D. F., Partmann, C., Parimbelli, G., Potter, D., Schneider, A., Schulz, S., Smith, R. E., Springel, V., Stadel, J., Tram, T., Viel, M., Villaescusa-Navarro, F., Winther, H. A., Wright, B. S., Zennaro, M., Aghanim, N., Amendola, L., Auricchio, N., Bonino, D., Branchini, E., Brescia, M., Camera, S., Capobianco, V., Cardone, V. F., Carretero, J., Castander, F. J., Castellano, M., Cavuoti, S., Cimatti, A., Cledassou, R., Congedo, G., Conversi, L., Copin, Y., Da Silva, A., Degaudenzi, H., Douspis, M., Dubath, F., Duncan, C. A. J., Dupac, X., Dusini, S., Farrens, S., Ferriol, S., Fosalba, P., Frailis, M., Franceschi, E., Galeotta, S., Garilli, B., Gillard, W., Gillis, B., Grazian, A., Haugan, S. V., Holmes, W., Hornstrup, A., Jahnke, K., Kermiche, S., Kiessling, A., Kilbinger, M., Kitching, T., Kunz, M., Kurki-Suonio, H., Lilje, P. B., Lloro, I., Mansutti, O., Marggraf, O., Marulli, F., Massey, R., Medinaceli, E., Meneghetti, M., Meylan, G., Moresco, M., Moscardini, L., Munari, E., Niemi, S. -M., Padilla, C., Paltani, S., Pasian, F., Pedersen, K., Percival, W. J., Pettorino, V., Polenta, G., Poncet, M., Popa, L. A., Raison, F., Rebolo, R., Renzi, A., Rhodes, J., Riccio, G., Romelli, E., Roncarelli, M., Saglia, R., Sapone, D., Sartoris, B., Schneider, P., Schrabback, T., Secroun, A., Seidel, G., Sirignano, C., Sirri, G., Stanco, L., Starck, J. -L., Tallada-Crespí, P., Taylor, A. N., Tereno, I., Toledo-Moreo, R., Torradeflot, F., Tutusaus, I., Valenziano, L., Vassallo, T., Wang, Y., Weller, J., Zacchei, A., Zamorani, G., Zoubian, J., Fabbian, G., and Scottez, V.

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

The measurement of the absolute neutrino mass scale from cosmological large-scale clustering data is one of the key science goals of the Euclid mission. Such a measurement relies on precise modelling of the impact of neutrinos on structure formation, which can be studied with $N$-body simulations. Here we present the results from a major code comparison effort to establish the maturity and reliability of numerical methods for treating massive neutrinos. The comparison includes eleven full $N$-body implementations (not all of them independent), two $N$-body schemes with approximate time integration, and four additional codes that directly predict or emulate the matter power spectrum. Using a common set of initial data we quantify the relative agreement on the nonlinear power spectrum of cold dark matter and baryons and, for the $N$-body codes, also the relative agreement on the bispectrum, halo mass function, and halo bias. We find that the different numerical implementations produce fully consistent results. We can therefore be confident that we can model the impact of massive neutrinos at the sub-percent level in the most common summary statistics. We also provide a code validation pipeline for future reference., Comment: 44 pages, 17 figures, 2 tables; v2: minor revision, accepted manuscript; published on behalf of the Euclid Consortium; data available at https://doi.org/10.5281/zenodo.7868793

Published
2022
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31. Effect of timing of casirivimab and imdevimab administration relative to mRNA-1273 COVID-19 vaccination on vaccine-induced SARS-CoV-2 neutralising antibody responses: a prospective, open-label, phase 2, randomised controlled trial

Author

Turner, Kenneth C, Kim, Yunji, Konis, George, Rosenthal, Mark J, Trbovic, Caryn F, Kowal, Bari, DiCioccio, A Thomas, Dakin, Paula, Isa, Flonza, Gonzalez Ortiz, Ana M, Meyer, Jonathan, Hamilton, Jennifer D, Olenchock, Benjamin A, Brackin, Taylor, Ganguly, Samit, Forleo-Neto, Eduardo, Faria, Lori, Heirman, Ingeborg, Marovich, Mary, Hutter, Julia, Polakowski, Laura, Irvin, Susan C, Thakur, Mazhar, Hooper, Andrea T, Baum, Alina, Petro, Christopher D, Fakih, Faisal A, McElrath, M Juliana, De Rosa, Stephen C, Cohen, Kristen W, Williams, LaTonya D, Hellman, Caleb A, Odeh, Ahmad J, Patel, Aloki H, Tomaras, Georgia D, Geba, Gregory P, Kyratsous, Christos A, Musser, Bret, Yancopoulos, George D, and Herman, Gary A

Published
2025
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35. A phase III study to evaluate the long-term safety and efficacy of fasinumab in patients with pain due to osteoarthritis of the knee or hip

Author

Stephen J. DiMartino, Jingning Mei, Thomas J. Schnitzer, Haitao Gao, Simon Eng, Christine Winslow, Tina Ho, Kenneth C. Turner, Hazem E. Hassan, Yamini Patel, John D. Davis, Ngan Trinh, Angela Manley, Garen Manvelian, Michael Fetell, Ned Braunstein, Gregory P. Geba, and Paula Dakin

Subjects
Fasinumab, Osteoarthritis, Pain, Safety, Diseases of the musculoskeletal system, RC925-935
Abstract

Background: Pain associated with osteoarthritis (OA) is frequently disabling; treatments are often ineffective or intolerable. Fasinumab selectively inhibits nerve-growth factor and has shown efficacy for the management of OA pain. Methods: In this randomized, double-blind, phase III safety study, patients with moderate-to-severe OA pain and history of inadequate pain relief received placebo or fasinumab (at 1, 3, 6, and 9 ​mg every 4 weeks [Q4W] and 1 and 6 ​mg every 8 weeks [Q8W] for 52 weeks). Primary safety endpoints included adverse events, adjudicated arthropathies (AAs), and joint replacements (JRs). Co-primary endpoints of an efficacy sub-study were change in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain and physical function scores. During the study, higher fasinumab doses were discontinued for safety; 1 ​mg doses continued. Results: Of 13,945 patients screened, 5331 were randomized; 1074 were included in the efficacy sub-study. AAs and JRs occurred in all groups. Increased severity of disease at baseline was associated with higher rates of AAs and JRs. A dose-dependent risk of AA or JR was observed for fasinumab; in the 1 ​mg groups, only a small percentage of patients with JR had prior AA. Fasinumab significantly improved WOMAC pain and physical function scores compared with placebo; least squares mean differences versus placebo were −1.22 and ​−1.20 for 1 ​mg Q4W and −0.73 and ​−0.74 for 1 ​mg Q8W, respectively (P

Published
2024
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36. Assessing the safety and pharmacokinetics of casirivimab and imdevimab (CAS+IMD) in a cohort of pregnant outpatients with COVID-19: results from an adaptive, multicentre, randomised, double-blind, phase 1/2/3 study

Author

Jing Xiao, Paula Dakin, Gregory P Geba, Edward Cox, Rafia Bhore, Jennifer D Hamilton, Shazia Ali, Yogesh Patel, Thomas D Norton, Mazhar Thakur, Samit Ganguly, Jesse Chao, Alpana Waldron, Kenneth C Turner, John D Davis, Susan C Irvin, Cynthia Pan, Dominique Atmodjo-Watkins, Andrea T Hooper, Danise Subramaniam, Joseph A Bocchini, Bari Kowal, A. Thomas DiCioccio, Ned Braunstein, and Gary A Herman

Subjects
Medicine
Abstract

Objective Pregnant women with COVID-19 are at elevated risk for severe outcomes, but clinical data on management of these patients are limited. Monoclonal antibodies, such as casirivimab plus imdevimab (CAS+IMD), have proven effective in treating non-pregnant adults with COVID-19, prompting further evaluation in pregnant women.Methods A phase 3 portion of an adaptive, multicentre, randomised, double-blind, placebo-controlled trial evaluated the safety, clinical outcomes, pharmacokinetics and immunogenicity of CAS+IMD (1200 mg or 2400 mg) in the treatment of pregnant outpatients with COVID-19 (NCT04425629). Participants were enrolled between December 2020 and November 2021, prior to the emergence of Omicron-lineage variants against which CAS+IMD is not active. Safety was evaluated in randomised participants who received study drug (n=80); clinical outcomes were evaluated in all randomised participants (n=82). Only two pregnant participants received placebo, limiting conclusions regarding treatment effect. Infants born to pregnant participants were followed for developmental outcomes ≤1 year of age.Results In pregnant participants, CAS+IMD was well tolerated, with no grade ≥2 hypersensitivity or infusion-related reactions reported. There were no participant deaths, and only one COVID-19–related medically attended visit. Although two pregnancies (3%) reported issues in the fetus/neonate, they were confounded by maternal history or considered to be due to an alternate aetiology. No adverse developmental outcomes in infants ≤1 year of age were considered related to in utero exposure to the study drug. CAS+IMD 1200 mg and 2400 mg rapidly and similarly reduced viral loads, with a dose-proportional increase in concentrations of CAS+IMD in serum. Pharmacokinetics were consistent with that reported in the general population. Immunogenicity incidence was low.Conclusion CAS+IMD treatment of pregnant outpatients with COVID-19 showed similar safety, clinical outcomes and pharmacokinetic profiles to that observed in non-pregnant adults. There was no evidence of an impact on developmental outcomes in infants ≤1 year of age.Trial registration number NCT04425629.

Published
2024
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37. Euclid preparation. XXIV. Calibration of the halo mass function in $\Lambda(\nu)$CDM cosmologies

Author

Euclid Collaboration, Castro, T., Fumagalli, A., Angulo, R. E., Bocquet, S., Borgani, S., Carbone, C., Dakin, J., Dolag, K., Giocoli, C., Monaco, P., Ragagnin, A., Saro, A., Sefusatti, E., Costanzi, M., Brun, A. M. C. Le, Corasaniti, P. -S., Amara, A., Amendola, L., Baldi, M., Bender, R., Bodendorf, C., Branchini, E., Brescia, M., Camera, S., Capobianco, V., Carretero, J., Castellano, M., Cavuoti, S., Cimatti, A., Cledassou, R., Congedo, G., Conversi, L., Copin, Y., Corcione, L., Courbin, F., Da Silva, A., Degaudenzi, H., Douspis, M., Dubath, F., Duncan, C. A. J., Dupac, X., Farrens, S., Ferriol, S., Fosalba, P., Frailis, M., Franceschi, E., Galeotta, S., Garilli, B., Gillis, B., Grazian, A., Grupp, F., Haugan, S. V. H., Hormuth, F., Hornstrup, A., Hudelot, P., Jahnke, K., Kermiche, S., Kitching, T., Kunz, M., Kurki-Suonio, H., Lilje, P. B., Lloro, I., Mansutti, O., Marggraf, O., Marulli, F., Meneghetti, M., Merlin, E., Meylan, G., Moresco, M., Moscardini, L., Munari, E., Niemi, S. M., Padilla, C., Paltani, S., Pasian, F., Pedersen, K., Pettorino, V., Pires, S., Polenta, G., Poncet, M., Popa, L., Pozzetti, L., Raison, F., Rebolo, R., Renzi, A., Rhodes, J., Riccio, G., Romelli, E., Saglia, R., Sapone, D., Sartoris, B., Schneider, P., Seidel, G., Sirri, G., Stanco, L., Crespí, P. Tallada, Taylor, A. N., Toledo-Moreo, R., Torradeflot, F., Tutusaus, I., Valentijn, E. A., Valenziano, L., Vassallo, T., Wang, Y., Weller, J., Zacchei, A., Zamorani, G., Andreon, S., Bardelli, S., Bozzo, E., Colodro-Conde, C., Di Ferdinando, D., Farina, M., Graciá-Carpio, J., Lindholm, V., Neissner, C., Scottez, V., Tenti, M., Zucca, E., Baccigalupi, C., Balaguera-Antolínez, A., Ballardini, M., Bernardeau, F., Biviano, A., Blanchard, A., Borlaff, A. S., Burigana, C., Cabanac, R., Cappi, A., Carvalho, C. S., Casas, S., Castignani, G., Cooray, A., Coupon, J., Courtois, H. M., Davini, S., De Lucia, G., Desprez, G., Dole, H., Escartin, J. A., Escoffier, S., Finelli, F., Ganga, K., Garcia-Bellido, J., George, K., Gozaliasl, G., Hildebrandt, H., Hook, I., Ilić, S., Kansal, V., Keihanen, E., Kirkpatrick, C. C., Loureiro, A., Macias-Perez, J., Magliocchetti, M., Maoli, R., Marcin, S., Martinelli, M., Martinet, N., Matthew, S., Maturi, M., Metcalf, R. B., Morgante, G., Nadathur, S., Nucita, A. A., Patrizii, L., Peel, A., Popa, V., Porciani, C., Potter, D., Pourtsidou, A., Pöntinen, M., Sánchez, A. G., Sakr, Z., Schirmer, M., Sereno, M., Mancini, A. Spurio, Teyssier, R., Valiviita, J., Veropalumbo, A., and Viel, M.

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

Euclid's photometric galaxy cluster survey has the potential to be a very competitive cosmological probe. The main cosmological probe with observations of clusters is their number count, within which the halo mass function (HMF) is a key theoretical quantity. We present a new calibration of the analytic HMF, at the level of accuracy and precision required for the uncertainty in this quantity to be subdominant with respect to other sources of uncertainty in recovering cosmological parameters from Euclid cluster counts. Our model is calibrated against a suite of N-body simulations using a Bayesian approach taking into account systematic errors arising from numerical effects in the simulation. First, we test the convergence of HMF predictions from different N-body codes, by using initial conditions generated with different orders of Lagrangian Perturbation theory, and adopting different simulation box sizes and mass resolution. Then, we quantify the effect of using different halo-finder algorithms, and how the resulting differences propagate to the cosmological constraints. In order to trace the violation of universality in the HMF, we also analyse simulations based on initial conditions characterised by scale-free power spectra with different spectral indexes, assuming both Einstein--de Sitter and standard $\Lambda$CDM expansion histories. Based on these results, we construct a fitting function for the HMF that we demonstrate to be sub-percent accurate in reproducing results from 9 different variants of the $\Lambda$CDM model including massive neutrinos cosmologies. The calibration systematic uncertainty is largely sub-dominant with respect to the expected precision of future mass-observation relations; with the only notable exception of the effect due to the halo finder, that could lead to biased cosmological inference., Comment: 25 pages, 21 figures, 5 tables, 3 appendixes; v2 matches published version

Published
2022
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38. COVID-19, Retention in HIV Care, and Access to Ancillary Services for Young Black Men Living with HIV in Chicago

Author

Voisin, Dexter R, Edwards, Travonne, Takahashi, Lois M, Valadez-Tapia, Silvia, Shah, Habiba, Oselett, Carter, Bouacha, Nora, Dakin, Andrea, and Quinn, Katherine

Subjects
Public Health, Health Sciences, Prevention, Minority Health, Sexually Transmitted Infections, Health Services, Clinical Research, Behavioral and Social Science, Health Disparities, Pediatric AIDS, Pediatric, HIV/AIDS, Mental Health, Sexual and Gender Minorities (SGM/LGBT*), Emerging Infectious Diseases, Social Determinants of Health, Infectious Diseases, Coronaviruses, 8.1 Organisation and delivery of services, Good Health and Well Being, Male, Humans, Homosexuality, Male, HIV Infections, Chicago, Sexual and Gender Minorities, COVID-19, HIV care continuum, Medical care improvements, YBMSM, Public Health and Health Services, Social Work, Public health
Abstract

This study conducted 28 semi-structured, in-depth interviews with Young Black Men who have Sex with Men in Chicago to investigate the impact of COVID-19 on their HIV care and ancillary service access. The qualitative analysis identified both negative and positive effects. The negative effects included: (l) mixed disruptions in linkage to and receipt of HIV care and ancillary services, and (2) heightened concerns about police and racial tensions in Chicago following the murder of George Floyd, contributing to possible disruption of retention in care. The positive effects included: (1) the ability to reflect and socially connect, contributing to heightened self-care and retention in care, and (2) some improvements in receipt of medical care. These findings suggest that while COVID-19 disruptions in care reduced in-person use of HIV care, the expansion of telemedicine allowed more administrative tasks to be handled online and focused in-person interactions on more substantive interactions.

Published
2023

41. Safety and efficacy of memantine and trazodone versus placebo for motor neuron disease (MND SMART): stage two interim analysis from the first cycle of a phase 3, multiarm, multistage, randomised, adaptive platform trial

Author

Gorrie, George, Morrison, Ian, Duncan, Callum, Carod Artal, Javier, Williams, Timothy, Srinivasan, Venkataramanan, Radunovic, Aleksandar, Pinto, Ashwin, Hamdalla, Hisham, Roberts, Rhys, Garcia- Reitboeck, Pablo, Harrower, Timothy, Mamutse, Godwin, Crawley, Francesca, Galton, Clare, Dawson, Kenneth, Forbes, Raeburn, Hillier, Charles, McDermott, Christopher, Forbes, Deborah, Bozkurt, Hatice, Stavrou, Maria, Kearns, Patrick, Breen, David, Kurucu King, Hatice, Elliot, Elizabeth, Beswick, Emily, Williamson, Jill, Cucurachi, Paolo, McLennan, Lucy, Pal, Suvankar, Chataway, Jeremy, Swingler, Robert, Macleod, Malcolm R, Carragher, Neil O, Hardingham, Giles, Selvaraj, Bhuvaneish Thangaraj, Smith, Colin, Wong, Charis, Newton, Judith, Lyle, Dawn, Stenson, Amy, Dakin, Rachel S, Ihenacho, Amarachi, Colville, Shuna, Mehta, Arpan R, Stallard, Nigel, Carpenter, James R, Parker, Richard A, Keerie, Catriona, Weir, Christopher J, Virgo, Bruce, Morris, Stevie, Waters, Nicola, Gray, Beverley, MacDonald, Donald, MacDonald, Euan, Parmar, Mahesh K B, and Chandran, Siddharthan

Published
2024
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43. Feasibility of a new ‘balanced binocular viewing’ treatment for unilateral amblyopia in children aged 3–8 years (BALANCE): results of a phase 2a randomised controlled feasibility trial

Author

Amanda Davis, Daniel Baker, Mohamed Abbas, Hakim-Moulay Dehbi, Annegret Hella Dahlmann-Noor, John A Greenwood, Andrew Skilton, Siobhan Ludden, Steven C Dakin, Emma Clay, Payal Khandelwal, and Denise Dunham

Subjects
Medicine
Abstract

Objectives This study aimed to evaluate the safety of dichoptic balanced binocular viewing (BBV) for amblyopia in children, plus feasibility, adherence, acceptability, trial methodology and clinical measures of visual function.Design We carried out an observer-masked parallel-group phase 2a feasibility randomised controlled trial.Setting Two study sites, a secondary/tertiary and a community site.Participants We enrolled 32 children aged 3–8 years with unilateral amblyopia who had completed optical adaptation where indicated. 20 children attended the 16-week exit visit (retention 63%).Interventions Children were randomised to BBV (movies customised to interocular acuity difference at baseline) for 1 hour a day (active intervention) or standard management as per parental choice (part-time occlusion or atropine blurring, control). All interventions were used at home, daily for 16 weeks.Primary outcome measure ‘VacMan suppression test’ of interocular balance at 16 weeks from randomisation. Secondary outcome measures: feasibility outcomes (recruitment and retention ratios, adherence with the allocated intervention); safety outcomes at other time points (changes in prevalence of diplopia, manifest strabismus, suppression/interocular balance on a range of tests); efficacy outcomes (clinical measures of visual function, such as best-corrected visual acuity, BCVA). Outcome measures were identical to those planned in the protocol.Results Primary outcome: At baseline, values for the interocular balance point were higher (indicating greater suppression of the amblyopic eye) in the occlusion group than in the BBV group. These values shifted downwards on average for the occlusion group, significantly decreasing from baseline to week 16 (t8=4.49, p=0.002). Balance values did not change between baseline and week 16 for the BBV group (t9=−0.82, p=0.435). At 16 weeks, there was no statistical difference in interocular balance/suppression change over time between the two arms. The difference at follow-up between the arms, adjusted for baseline, was −0.02 (95% CI −0.28 to 0.23, p=0.87). Feasibility: We prescreened 144 records of potentially eligible children. Between 28 October 2019 and 31 July 2021, including an interruption due to the COVID-19 pandemic, 32 children were screened and randomised (recruitment rate 22%), 16 to BBV and 16 to standard treatment. 20 children attended the 16-week exit visit (retention 63%). Mean adherence with BBV as proportion of viewing time prescribed was 56.1% (SD36) at 8 and 57.9% (SD 30.2) at 16 weeks. Mean adherence with prescribed occlusion time was 90.1% (SD 19.7) at 8 and 59.2% (SD 24.8) at 16 weeks.Secondary safety/efficacy outcomes One child in the BBV arm reported transient double vision, which resolved; two reported headaches, which led to withdrawal. BCVA improved from mean 0.47 (SD0.18) logMAR at randomisation to 0.26 (0.14) with standard treatment, and from 0.55 (0.28) to 0.32 (0.26) with BBV. Outcomes at 16 weeks did not differ between treatments.Participant experience Families were generally positive about BBV, but families found both patching and BBV difficult to integrate into family routines.Conclusions Recruitment rates indicate that a future phase 3 trial will require multiple sites or a longer enrolment period. Retention and adherence rates were lower than anticipated, which will influence future study designs. Dichoptic treatment may be equal to occlusion treatment in safety and efficacy; headaches may lead to discontinuation. Integration into family routines may constitute a barrier to implementation.Trial registration number NCT03754153.

Published
2024
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44. The cosmological simulation code $\scriptstyle{\rm CO}N{\rm CEPT}\, 1.0$

Author

Dakin, Jeppe, Hannestad, Steen, and Tram, Thomas

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

We present version 1.0 of the cosmological simulation code $\scriptstyle{\rm CO}N{\rm CEPT}$, designed for simulations of large-scale structure formation. $\scriptstyle{\rm CO}N{\rm CEPT}\, 1.0$ contains a P$^3$M gravity solver, with the short-range part implemented using a novel (sub)tiling strategy, coupled with individual and adaptive particle time-stepping. A primary objective of $\scriptstyle{\rm CO}N{\rm CEPT}$ is ease of use. To this end, it has built-in initial condition generation and can produce output in the form of snapshots, power spectra and direct visualisations. $\scriptstyle{\rm CO}N{\rm CEPT}$ is the first massively parallel cosmological simulation code written in Python. Despite of this, excellent performance is obtained, even comparing favourably to other codes such as $\scriptstyle{\rm GADGET}$ at similar precision, in the case of low to moderate clustering. By means of power spectrum comparisons we find extraordinary good agreement between $\scriptstyle{\rm CO}N{\rm CEPT}\, 1.0$ and $\scriptstyle{\rm GADGET}$. At large and intermediate scales the codes agree to well below the per mille level, while the agreement at the smallest scales probed ($k \sim 13\, h/{\rm Mpc}$) is of the order of $1\, \%$. The $\scriptstyle{\rm CO}N{\rm CEPT}$ code is openly released and comes with a robust installation script as well as thorough documentation., Comment: Matches the published MNRAS version. 27 pages, 13 figures. For the code, see https://github.com/jmd-dk/concept

Published
2021
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45. Selective advantage of mutant stem cells in human clonal hematopoiesis is associated with attenuated response to inflammation and aging

Author

Jakobsen, Niels Asger, Turkalj, Sven, Zeng, Andy G.X., Stoilova, Bilyana, Metzner, Marlen, Rahmig, Susann, Nagree, Murtaza S., Shah, Sayyam, Moore, Rachel, Usukhbayar, Batchimeg, Angulo Salazar, Mirian, Gafencu, Grigore-Aristide, Kennedy, Alison, Newman, Simon, Kendrick, Benjamin J.L., Taylor, Adrian H., Afinowi-Luitz, Rasheed, Gundle, Roger, Watkins, Bridget, Wheway, Kim, Beazley, Debra, Murison, Alex, Aguilar-Navarro, Alicia G., Flores-Figueroa, Eugenia, Dakin, Stephanie G., Carr, Andrew J., Nerlov, Claus, Dick, John E., Xie, Stephanie Z., and Vyas, Paresh

Published
2024
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47. Stereotactic radiotherapy for neovascular age-related macular degeneration (STAR): a pivotal, randomised, double-masked, sham-controlled device trial

Author

Abugreen, Salwa, Bindra, Mandeep, Burton, Ben, Dias, Indra, Dinah, Christiana, Gandhewar, Ravikiran, Georgas, Athanasios, Goverdhan, Srinivas, Gulrez, Ansari, Haynes, Richard, Hughes, Edward, Jackson (Chief Investigator), Timothy, Jafree, Afsar, Joseph, Sobha, Kashab, Tarek, Membrey, Luke, Menon, Geeta, Misra, Aseema, Narendran, Niro, Newman, Douglas, Patel, Jignesh, Patra, Sudeshna, Petrarca, Robert, Priya, Prakash, Rashi, Arora, Salom, Ramiro, Shah, Paritosh, Shahrnaz, Izadi, Sheen, George, Shiew, Marianne, Tesha, Paul, Vrizidou, Eleni, Jackson, Timothy L, Desai, Riti, Wafa, Hatem A, Wang, Yanzhong, Peacock, Janet, Peto, Tunde, Chakravarthy, Usha, Dakin, Helen, Wordsworth, Sarah, Lewis, Cornelius, Clinch, Patricia, Ramazzotto, Lisa, Neffendorf, James E, Lee, Chan Ning, O'Sullivan, Joe M, and Reeves, Barnaby C

Published
2024
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48. Fit-for-Purpose Ki-67 Immunohistochemistry Assays for Breast Cancer

Author

Torlakovic, Emina E., Baniak, Nick, Barnes, Penny J., Chancey, Keith, Chen, Liam, Cheung, Carol, Clairefond, Sylvie, Cutz, Jean-Claude, Faragalla, Hala, Gravel, Denis H., Dakin Hache, Kelly, Iyengar, Pratibha, Komel, Michael, Kos, Zuzana, Lacroix-Triki, Magali, Marolt, Monna J., Mrkonjic, Miralem, Mulligan, Anna Marie, Nofech-Mozes, Sharon, Park, Paul C., Plotkin, Anna, Raphael, Simon, Rees, Henrike, Seno, H Rommel, Thai, Duc-Vinh, Troxell, Megan L., Varma, Sonal, Wang, Gang, Wang, Tao, Wehrli, Bret, and Bigras, Gilbert

Published
2024
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