547 results on '"Dallemagne, Patrick"'
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2. Synthesis, in vitro and in vivo biological evaluation of novel dual compounds targeting both acetylcholinesterase and serotonergic 5-HT4 receptors with potential interest in the treatment of Alzheimer's disease
3. Matrix metalloproteinases as new targets in Alzheimer's disease: Opportunities and Challenges
4. A novel inhibitor of the mitochondrial respiratory complex I with uncoupling properties exerts potent antitumor activity
5. Design, synthesis and biological characterization of novel activators of the TrkB neurotrophin receptor
6. Evidence from a mouse model supports repurposing an anti-asthmatic drug, bambuterol, against Alzheimer's disease by administration through an intranasal route.
7. Indirect influence on the BDNF/TrkB receptor signaling pathway via GPCRs, an emerging strategy in the treatment of neurodegenerative disorders.
8. Desirable drug–drug interactions or when a matter of concern becomes a renewed therapeutic strategy
9. Pleiotropic prodrugs: Design of a dual butyrylcholinesterase inhibitor and 5-HT6 receptor antagonist with therapeutic interest in Alzheimer’s disease
10. Phenanthrolinic analogs of quinolones show antibacterial activity against M. tuberculosis
11. Identification of antiviral compounds against equid herpesvirus-1 using real-time cell assay screening: Efficacy of decitabine and valganciclovir alone or in combination
12. hERG toxicity assessment: Useful guidelines for drug design
13. Discovery of a pocket network on the domain 5 of the TrkB receptor – A potential new target in the quest for the new ligands
14. Novel multi target-directed ligands targeting 5-HT4 receptors with in cellulo antioxidant properties as promising leads in Alzheimer's disease
15. Benzothienoquinazolinones as new multi-target scaffolds: Dual inhibition of human Topoisomerase I and tubulin polymerization
16. New piperazine multi-effect drugs prevent neurofibrillary degeneration and amyloid deposition, and preserve memory in animal models of Alzheimer's disease
17. Development of Pleiotropic TrkB and 5-HT4 Receptor Ligands as Neuroprotective Agents
18. Synthesis and interest in medicinal chemistry of β-phenylalanine derivatives (β-PAD): an update (2010–2022).
19. Novel multitarget-directed ligands targeting acetylcholinesterase and σ1 receptors as lead compounds for treatment of Alzheimer's disease: Synthesis, evaluation, and structural characterization of their complexes with acetylcholinesterase
20. Screening and evaluation of antiviral compounds against Equid alpha-herpesviruses using an impedance-based cellular assay
21. Conceptual Framework of the Design of Pleiotropic Drugs against Alzheimer’s Disease
22. Replication of Equine arteritis virus is efficiently suppressed by purine and pyrimidine biosynthesis inhibitors
23. Multifaceted properties of 1,4-dimethylcarbazoles: Focus on trimethoxybenzamide and trimethoxyphenylurea derivatives as novel human topoisomerase II inhibitors
24. Pleiotropic Drugs against Alzheimer’s Disease
25. Inducing neuronal regeneration and differentiation via the BDNF/TrkB signaling pathway: a key target against neurodegenerative diseases?
26. A novel inhibitor of the mitochondrial respiratory complex I with uncoupling properties exerts potent antitumor activity
27. Design, synthesis, and pharmacological evaluation of multitarget-directed ligands with both serotonergic subtype 4 receptor (5-HT4R) partial agonist and 5-HT6R antagonist activities, as potential treatment of Alzheimer’s disease
28. Synthesis and evaluation of novel serotonin 4 receptor radiotracers for single photon emission computed tomography
29. Novel benzylidenephenylpyrrolizinones with pleiotropic activities potentially useful in Alzheimer's disease treatment
30. 3-(Dipropylamino)-5-hydroxybenzofuro[2,3-f]quinazolin-1(2H)-one (DPA-HBFQ-1) plays an inhibitory role on breast cancer cell growth and progression
31. Rational design of novel benzisoxazole derivatives with acetylcholinesterase inhibitory and serotoninergic 5-HT4 receptors activities for the treatment of Alzheimer’s disease
32. A chemical screen identifies two novel small compounds that alter Arabidopsis thaliana pollen tube growth
33. Biginelli Reaction Synthesis of Novel Multitarget-Directed Ligands with Ca2+ Channel Blocking Ability, Cholinesterase Inhibition, Antioxidant Capacity, and Nrf2 Activation
34. Development of Pleiotropic TrkB and 5-HT 4 Receptor Ligands as Neuroprotective Agents.
35. Chronic activation of 5-HT4 receptors or blockade of 5-HT6 receptors improve memory performances
36. Discovery of new thienopyrimidinone derivatives displaying antimalarial properties toward both erythrocytic and hepatic stages of Plasmodium
37. 6-Sulfonylbenzothiazolones as potential scaffolds for the design of 5-HT6 ligands
38. C3-Symmetric Ligands in Drug Design: When the Target Controls the Aesthetics of the Drug
39. Biginelli Reaction Synthesis of Novel Multitarget-Directed Ligands with Ca2+ Channel Blocking Ability, Cholinesterase Inhibition, Antioxidant Capacity, and Nrf2 Activation
40. Synthesis and in vitro evaluation of 4-trichloromethylpyrrolo[1,2-a]quinoxalines as new antiplasmodial agents
41. Design of donecopride, a dual serotonin subtype 4 receptor agonist/acetylcholinesterase inhibitor with potential interest for Alzheimer's disease treatment
42. MR22388, a novel anti-cancer agent with a strong FLT-3 ITD kinase affinity
43. Synthesis of novel 7-oxo and 7-hydroxy trifluoroallocolchicinoids with cytotoxic effect
44. One-pot synthesis of new aza- and diaza-aminophenanthrenes
45. First and mild synthesis of fluorene-9-malonic acid and some substituted derivatives via the intramolecular hydroarylation of 2-phenylbenzylidenemalonic acids
46. Hydrogenative desulphurization of thienopyrrolizinones: An easy and selective access to ( Z)-phenethylidenepyrrolizinones with in vitro cytotoxic activity
47. One-pot synthesis of novel poly-substituted phenanthrenes
48. Advances in prodrug design for Alzheimer’s disease: the state of the art
49. Active Targeted Nanoemulsions for Repurposing of Tegaserod in Alzheimer’s Disease Treatment
50. Development of a high‐throughput screening assay to identify equine virus arteritis replication inhibitors
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