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2. International cross-sectional survey on current and updated definitions of intra-abdominal hypertension and abdominal compartment syndrome

Author

Nasa, Prashant, Wise, Robert D., Smit, Marije, Acosta, Stefan, D’Amours, Scott, Beaubien–Souligny, William, Bodnar, Zsolt, Coccolini, Federico, Dangayach, Neha S., Dabrowski, Wojciech, Duchesne, Juan, Ejike, Janeth C., Augustin, Goran, De Keulenaer, Bart, Kirkpatrick, Andrew W., Khanna, Ashish K., Kimball, Edward, Koratala, Abhilash, Lee, Rosemary K., Leppaniemi, Ari, Lerma, Edgar V., Marmolejo, Valerie, Meraz–Munoz, Alejando, Myatra, Sheila N., Niven, Daniel, Olvera, Claudia, Ordoñez, Carlos, Petro, Clayton, Pereira, Bruno M., Ronco, Claudio, Regli, Adrian, Roberts, Derek J., Rola, Philippe, Rosen, Michael, Shrestha, Gentle S., Sugrue, Michael, Velez, Juan Carlos Q., Wald, Ron, De Waele, Jan, Reintam Blaser, Annika, and Malbrain, Manu L. N. G.

Published
2024
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3. Derivation, external and clinical validation of a deep learning approach for detecting intracranial hypertension

Author

Gulamali, Faris, Jayaraman, Pushkala, Sawant, Ashwin S., Desman, Jacob, Fox, Benjamin, Chang, Annette, Soong, Brian Y., Arivazagan, Naveen, Reynolds, Alexandra S., Duong, Son Q., Vaid, Akhil, Kovatch, Patricia, Freeman, Robert, Hofer, Ira S., Sakhuja, Ankit, Dangayach, Neha S., Reich, David S., Charney, Alexander W., and Nadkarni, Girish N.

Published
2024
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4. Research considerations for prospective studies of patients with coma and disorders of consciousness

Author

Tinti, Lorenzo, Lawson, Thomas, Molteni, Erika, Kondziella, Daniel, Rass, Verena, Sharshar, Tarek, Bodien, Yelena G, Giacino, Joseph T, Mayer, Stephan A, Amiri, Moshgan, Muehlschlegel, Susanne, Rao, Chethan P Venkatasubba, Vespa, Paul M, Menon, David K, Citerio, Giuseppe, Helbok, Raimund, McNett, Molly, Agarwal, Sachin, Aiyagari, Venkatesh, Akbari, Yama, Albertson, Asher, Alexander, Sheila, Alexandrov, Anne, Alkhachroum, Ayham, Al-Mufti, Fawaz, Amiri, Moshagan, Appavu, Brian, Gebrewold, Meron Awraris, Ayounb, Marc, Badenes, Rafael, Bader, Mary Kay, Badjiata, Neeraj, Balu, Ram, Barlow, Brooke, Barra, Megan, Beekman, Rachel, Beghi, Ettore, Beqiri, Erta, Berlin, Tracey, Bilotta, Federico, Bleck, Thomas, Bodien, Yelena, Boerwinkle, Varina, Boly, Melanie, Bonnel, Alexandra, Brazzi, Luca, Brown, Emery, Bulic, Sebina, Caceres, Eder, Caceres, Adrian, Cafiero, Tullio, Carroll, Elizabeth, Cediel, Emilio G, Chou, Sherry, Claassen, Jan, Condie, Chad, Conti, Alfredo, Cosmas, Katie, Costa, Paolo, Creutzfeldt, Claire, Dangayach, Neha, Dauri, Mario, Debicki, Derek, DeGeorgia, Michael, Der-Nigoghossian, Caroline, Desai, Masoom, Dhar, Rajat, Diringer, Michael, Durr, Emily, Edlow, Brian, Ercole, Ari, Estraneo, Anna, Falcone, Guido, Farrokh, Salia, Ferguson, Adam, Fernandez-Espejo, Davinia, Fink, Ericka, Fins, Joseph, Foreman, Brandon, Franchi, Federico, Frontera, Jennifer, Ganesan, Rishi, Gaspard, Nicolas, Ghavam, Ahmeneh, Giacino, Joseph, Gibbons, Christie, Gilmore, Emily, Glustein, Chavie, Gosseries, Olivia, Green, Theresa, Greer, David, Guanci, Mary, Gupta, Deepak, Hahn, Cecil, Hakimi, Ryan, Hammond, Flora, Hanley, Daniel F, Hartings, Jed, and Hassan, Ahmed

Subjects
Biological Psychology, Biomedical and Clinical Sciences, Psychology, Neurosciences, Brain Disorders, Prevention, Curing Coma Campaign Collaborators, coma, design, disorders of consciousness, outcomes, prospective studies, Clinical sciences, Biological psychology
Abstract

Disorders of consciousness are neurological conditions characterized by impaired arousal and awareness of self and environment. Behavioural responses are absent or are present but fluctuate. Disorders of consciousness are commonly encountered as a consequence of both acute and chronic brain injuries, yet reliable epidemiological estimates would require inclusive, operational definitions of the concept, as well as wider knowledge dissemination among involved professionals. Whereas several manifestations have been described, including coma, vegetative state/unresponsive wakefulness syndrome and minimally conscious state, a comprehensive neurobiological definition for disorders of consciousness is still lacking. The scientific literature is primarily observational, and studies-specific aetiologies lead to disorders of consciousness. Despite advances in these disease-related forms, there remains uncertainty about whether disorders of consciousness are a disease-agnostic unitary entity with a common mechanism, prognosis or treatment response paradigm. Our knowledge of disorders of consciousness has also been hampered by heterogeneity of study designs, variables, and outcomes, leading to results that are not comparable for evidence synthesis. The different backgrounds of professionals caring for patients with disorders of consciousness and the different goals at different stages of care could partly explain this variability. The Prospective Studies working group of the Neurocritical Care Society Curing Coma Campaign was established to create a platform for observational studies and future clinical trials on disorders of consciousness and coma across the continuum of care. In this narrative review, the author panel presents limitations of prior observational clinical research and outlines practical considerations for future investigations. A narrative review format was selected to ensure that the full breadth of study design considerations could be addressed and to facilitate a future consensus-based statement (e.g. via a modified Delphi) and series of recommendations. The panel convened weekly online meetings from October 2021 to December 2022. Research considerations addressed the nosographic status of disorders of consciousness, case ascertainment and verification, selection of dependent variables, choice of covariates and measurement and analysis of outcomes and covariates, aiming to promote more homogeneous designs and practices in future observational studies. The goal of this review is to inform a broad community of professionals with different backgrounds and clinical interests to address the methodological challenges imposed by the transition of care from acute to chronic stages and to streamline data gathering for patients with disorders of consciousness. A coordinated effort will be a key to allow reliable observational data synthesis and epidemiological estimates and ultimately inform condition-modifying clinical trials.

Published
2023

6. The Brain-Abdominal Interaction

Author

Dabrowski, Wojciech, Robba, Chaira, Dangayach, Neha S., Malbrain, Manu L. N. G., Coccolini, Federico, Series Editor, Coimbra, Raul, Series Editor, Kirkpatrick, Andrew W., Series Editor, Di Saverio, Salomone, Series Editor, Ansaloni, Luca, Editorial Board Member, Balogh, Zsolt, Editorial Board Member, Biffl, Walt, Editorial Board Member, Catena, Fausto, Editorial Board Member, Davis, Kimberly, Editorial Board Member, Ferrada, Paula, Editorial Board Member, Fraga, Gustavo, Editorial Board Member, Ivatury, Rao, Editorial Board Member, Kluger, Yoram, Editorial Board Member, Leppaniemi, Ari, Editorial Board Member, Maier, Ron, Editorial Board Member, Moore, Ernest E., Editorial Board Member, Napolitano, Lena, Editorial Board Member, Peitzman, Andrew, Editorial Board Member, Reilly, Patrick, Editorial Board Member, Rizoli, Sandro, Editorial Board Member, Sakakushev, Boris E., Editorial Board Member, Sartelli, Massimo, Editorial Board Member, Scalea, Thomas, Editorial Board Member, Spain, David, Editorial Board Member, Stahel, Philip, Editorial Board Member, Sugrue, Michael, Editorial Board Member, Velmahos, George, Editorial Board Member, Weber, Dieter, Editorial Board Member, Brogi, Etrusca, editor, Ley, Eric J., editor, and Valadka, Alex, editor

Published
2024
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7. Intravenous glibenclamide for cerebral oedema after large hemispheric stroke (CHARM): a phase 3, double-blind, placebo-controlled, randomised trial

Author

Abraham, Michael, Acosta, Indrani, Agostoni, Elio Clemente, Aguera Morales, Eduardo, Akaike, Yuji, Ale Bark, Samir, Alexandrov, Andrei, Altschul, Dorothea, Arenillas Lara, Juan Francisco, Arias Rivas, Susana, Arnold, Marcel, Asimos, Andrew, Bar, Michal, Barlinn, Kristian, Beccia, Mario, Benesch, Curtis, Bereczki, Daniel, Berk, Julie, Berkeley, Jennifer, Berrouschot, Joerg, Bettermann, Kerstin, Bevers, Matthew, Bösel, Julian, Bogdanov, Enver, Bonato, Sara, Bornstein, Natan, Boutwell, Christine, Bowling, Susana, Brown, Helen, Bruno, Askiel, Burgin, William, Bustamante, Rafael, Cabral Moro, Carla Heloísa, Cao, Wenfeng, Carandang, Raphael, Cardona Portela, Pedro, Castro, Pedro, Cativo, Maria, Cereda, Carlo, Cerejo, Russell, Chang, Chiung-Chih, Cheng, Roger, Chin, Masaki, Ching, Marilou, Christensen, Hanne, Chung, Lee, Clark, Jonie, Clark, Wayne, Cloud, Geoffrey, Cogez, Julien, Comi, Giancarlo, Cordato, Dennis, Coull, Bruce, Cronin, Carolyn, Csanyi, Attila, Cullis, Paul, Czeisler, Barry, Dangayach, Neha, Datta, Mohit, Debouverie, Marc, Demchuk, Andrew, Denier, Christian, Desfontaines, Philippe, Devlin, Thomas, Dhar, Rajat, Diomedi, Marina, Dioszeghy, Peter, Diringer, Michael, Dixit, Anand, Dong, Qiang, Eichel, Roni, Elliott, Jamie, Fan, Dongsheng, Fernandez Sanchez, Victoria Eugenia, Ferro, José Manuel, Finocchi, Cinzia, Foreman, Brandon, Fortea Cabo, Gerardo, Freire Goncalves, Antonio, Fukuyama, Kozo, Gamero Garcia, Miguel Angel, Garcia Esperon, Carlos, Geng, Deqin, Ghoshal, Shivani, Gomes, Joao, Gordon, Errol, Guillon, Benoit, Hagihara, Yasushi, Hallevi, Hen, Halse, Omid, Han, Moon-Ku, Hargis, Mitch, Harnof, Sagi, Harsany, Michal, Hasegawa, Yasuhiro, Hassan, Ameer, Hayasaka, Michihiro, He, Jincai, Hemelsoet, Dimitri, Henon, Hilde, Herzig, Roman, Hill, Michael, Hinduja, Archana, Hirano, Teruyuki, Horev, Anat, Howell, Bradley, Hu, Xingyue, Huang, David, Hwang, Yangha, Ifergane, Gal, Isayev, Yevgeniy, Ito, Yasuhiro, Iversen, Helle, Jatuzis, Dalius, Jeng, Jiann-Shing, Jeon, Sang-Beom, Jeong, Jin-Heon, Ji, Qiuhong, Kahles, Timo, Kallmuenzer, Bernd, Kaneko, Chikako, Kanzawa, Takao, Kasner, Scott, Kawabata, Masayuki, Kelly, Adam, Kerrigan, Deborah, Keshary, Sanjeev, Khanna, Anna, Kidjemet-Piskac, Spomenka, Kidwell, Chelsea, Kim, Minjee, Kimura, Kazumi, Kimura, Naoto, Kin, Shigenari, Kirmani, Jawad, Kitazawa, Kazuo, Kleinig, Timothy, Koehrmann, Martin, Koga, Masatoshi, Kollmar, Rainer, Konno, Hiromu, Krause, Martin, Kuga, Yoshihiro, Kullman, Dimitri, Kurka, Natalia, Lago Martin, Aida, Latorre, Julius (Gene), LeDoux, David, Leal Loureiro, Jose, Lebedeva, Anna, Lee, Tsong-Hai, Leker, Ronen, Lemmens, Robin, Li, Yansheng, Lioutas, Vasileious-Arsenios, Liu, Chunfeng, Liu, Liping, Liu, Wei, Liu, Yaling, Longoni, Marco, Lopez, George, Lord, Aaron, Lu, Zuneng, Machida, Akira, Magoni, Mauro, Malik, Maheen, Marcheselli, Simona, Marques Pontes Neto, Octávio, Martin, Jerry, Martino, Stephen, Martins Maia Carvalho, Fernanda, Masjuan Vallejo, Jaime, Matijosaitis, Vaidas, Mayer, Stephan, McGrade, Harold, Mehta, Sanal, Melmed, Kara, Melnikova, Elena, Messe, Steven, Meyer, Brett, Miller, Chad, Minnerup, Jens, Mittal, Shilpi, Molina Cateriano, Carlos, Moniche Alvarez, Francisco, Moroi, Junta, Moulin, Thierry, Muir, Keith, Murase, Satoru, Murialdo, Alessandra, Muscat, Paul, Nagy, Ferenc, Nakagawa, Kazuma, Nakagawa, Koshi, Nakano, Shin, Naval, Neeraj, Nencini, Patrizia, Ng, Kwan, Niesen, Wolf-Dirk, Nomura, Sadahiro, Olds, Karin, Olga, Samoshkina, Ota, Shinzo, Ouriques Martins, Sheila Cristina, Ovary, Csaba, Panczel, Gyula, Peretz, Shlomi, Perry, Richard, Petersen, Nils, Phan, Thanh, Pinho e Melo, Teresa, Poisson, Sharon, Poljakovic, Zdravka, Pulido, Angel, Radai, Ferenc, Ramiro, Joanna Isabelle I., Ramos-Estebanez, Ciro, Ratcliff, Jonathan, Renati, Swetha, Richard, Sébastien, Rincon, Fred, Rippee, Michael, Rocha, Marcelo, Rodrigues, Miguel, Rodriguez Campello, Ana, Roh, David, Roje Bedekovic, Marina, Roquer Gonzalez, Jaime, Roriz Cruz, Matheus, Roriz, José Mário, Roshkovskaya, Ludmila, Roveri, Luisa, Ruano, Luis, Rubio Borrego, Francisco, Ruuskanen, Jori, Rybinnik, Igor, Sabet, Arman, Sakai, Nobuyuki, Sampaio Silva, Gisele, Santo, Gustavo, Sarwal, Aarti, Sato, Kenichi, Sato, Kota, Sattin, Justin, Schaefer, Jan-Hendrik, Schneider, Hauke, Serena Leal, Joaquin, Shah, Ruchir, Shah, Shreyansh, Sharma, Kartavya, Shepherd, Starane, Shi, Fudong, Shimoe, Yutaka, Shuaib, Ashfaq, Sibon, Igor, Silliman, Scott, Skorna, Miroslav, Snider, Samuel, Soda, Hassan, Sprigg, Nikola, Stetkarova, Ivana, Strbian, Daniel, Streib, Christopher, Stretz, Hanns Christoph, Sugimori, Hiroshi, Sundararajan, Sophia, Sung, Pi-Shan, Sztriha, Laszlo, Takahashi, Shinichi, Takizawa, Katsumi, Takizawa, Shunya, Tang, Sung-Chun, Tassi, Rosanna, Tayal, Ashis, Tedim Cruz, Vitor, Telman, Gregory, Temes, Richard, Terry, John, Tian, Xiangyang, Timchenko, Ludmila, Timsit, Serge, Tirschwell, David, Tokunaga, Koji, Tomek, Ales, Toni, Danilo, Torbey, Michel, Ueda, Masayuki, Uriel, Eitan, Valverde Moyano, Roberto, Vandermeeren, Yves, Vannier, Stéphane, Vargas, Alejandro, Vecsei, Laszlo, Veltkamp, Roland, Venkatasubramanian, Chitra, Viana Baptista, Miguel, Vilionskis, Aleksandras, Vohanka, Stanislav, Voznyuk, Igor, Wang, Furong, Wang, Guoping, Wang, Ning, Warburton, Elizabeth, Waters, Michael, Wen, Guoqiang, Wendell, Linda, Werring, David, Wienecke, Troels, Wijeratne, Tissa, Wilson, Laura, Witt, John, Wu, Jin, Xiong, Yingqiong, Xu, En, Xu, Jindong, Yamano, Yoshihisa, Yan, Fuling, Yang, Yi, Yi, Fei, Youn, Teddy, Zachariah, George, Zafar, Sahar, Zaidi, Syed, Zammit, Christopher, Zeng, Jinsheng, Zhang, Guilian, Zhang, Meng, Zini, Andrea, Zinke, Jan, Zurasky, John, Sheth, Kevin N, Albers, Gregory W, Saver, Jeffrey L, Campbell, Bruce C V, Molyneaux, Bradley J, Hinson, H E, Cordonnier, Charlotte, Steiner, Thorsten, Toyoda, Kazunori, Wintermark, Max, Littauer, Ross, Collins, Jessica, Lucas, Nisha, Nogueira, Raul G, Simard, J Marc, Wald, Michael, Dawson, Kate, and Kimberly, W Taylor

Published
2024
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11. Characteristics of Post-ICU and Post-COVID Recovery Clinics in 29 U.S. Health Systems

Author

Danesh, Valerie, Boehm, Leanne M, Eaton, Tammy L, Arroliga, Alejandro C, Mayer, Kirby P, Kesler, Shelli R, Bakhru, Rita N, Baram, Michael, Bellinghausen, Amy L, Biehl, Michelle, Dangayach, Neha S, Goldstein, Nir M, Hoehn, K Sarah, Islam, Marjan, Jagpal, Sugeet, Johnson, Annie B, Jolley, Sarah E, Kloos, Janet A, Mahoney, Eric J, Maley, Jason H, Martin, Sara F, McSparron, Jakob I, Mery, Marissa, Saft, Howard, Santhosh, Lekshmi, Schwab, Kristin, Villalba, Dario, Sevin, Carla M, and Montgomery, Ashley A

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Behavioral and Social Science, Prevention, Good Health and Well Being, administration, healthcare delivery, postacute sequelae of COVID-19, postintensive care syndrome, severe acute respiratory syndrome coronavirus-2, Clinical sciences
Abstract

The multifaceted long-term impairments resulting from critical illness and COVID-19 require interdisciplinary management approaches in the recovery phase of illness. Operational insights into the structure and process of recovery clinics (RCs) from heterogeneous health systems are needed. This study describes the structure and process characteristics of existing and newly implemented ICU-RCs and COVID-RCs in a subset of large health systems in the United States.DesignCross-sectional survey.SettingThirty-nine RCs, representing a combined 156 hospitals within 29 health systems participated.PatientsNone.InterventionsNone.Measurement and main resultsRC demographics, referral criteria, and operating characteristics were collected, including measures used to assess physical, psychologic, and cognitive recoveries. Thirty-nine RC surveys were completed (94% response rate). ICU-RC teams included physicians, pharmacists, social workers, physical therapists, and advanced practice providers. Funding sources for ICU-RCs included clinical billing (n = 20, 77%), volunteer staff support (n = 15, 58%), institutional staff/space support (n = 13, 46%), and grant or foundation funding (n = 3, 12%). Forty-six percent of RCs report patient visit durations of 1 hour or longer. ICU-RC teams reported use of validated scales to assess psychologic recovery (93%), physical recovery (89%), and cognitive recovery (86%) more often in standard visits compared with COVID-RC teams (psychologic, 54%; physical, 69%; and cognitive, 46%).ConclusionsOperating structures of RCs vary, though almost all describe modest capacity and reliance on volunteerism and discretionary institutional support. ICU- and COVID-RCs in the United States employ varied funding sources and endorse different assessment measures during visits to guide care coordination. Common features include integration of ICU clinicians, interdisciplinary approach, and focus on severe critical illness. The heterogeneity in RC structures and processes contributes to future research on the optimal structure and process to achieve the best postintensive care syndrome and postacute sequelae of COVID outcomes.

Published
2022

12. Medical Education During the COVID-19 Pandemic

Author

Kaul, Viren, Gallo de Moraes, Alice, Khateeb, Dina, Greenstein, Yonatan, Winter, Gretchen, Chae, JuneMee, Stewart, Nancy H, Qadir, Nida, and Dangayach, Neha S

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Patient Safety, Good Health and Well Being, COVID-19, Communicable Disease Control, Education, Medical, Humans, Organizational Innovation, SARS-CoV-2, MedEd, medical education, pandemic, Respiratory System, Cardiovascular medicine and haematology, Clinical sciences
Abstract

All aspects of medical education were affected by the COVID-19 pandemic. Several challenges were experienced by trainees and programs alike, including economic repercussions of the pandemic; social distancing affecting the delivery of medical education, testing, and interviewing; the surge of patients affecting redeployment of personnel and potential compromises in core training; and the overall impact on the wellness and mental health of trainees and educators. The ability of medical teams and researchers to peer review, conduct clinical research, and keep up with literature was similarly challenged by the rapid growth in peer-reviewed and preprint literature. This article reviews these challenges and shares strategies that institutions, educators, and learners adopted, adapted, and developed to provide quality education during these unprecedented times.

Published
2021

15. Implementation of a Virtual Interprofessional ICU Learning Collaborative: Successes, Challenges, and Initial Reactions From the Structured Team-Based Optimal Patient-Centered Care for Virus COVID-19 Collaborators

Author

Zec, Simon, Zorko Garbajs, Nika, Dong, Yue, Gajic, Ognjen, Kordik, Christina, Harmon, Lori, Bogojevic, Marija, Singh, Romil, Sun, Yuqiang, Bansal, Vikas, Vu, Linh, Cawcutt, Kelly, Litell, John M., Redmond, Sarah, Fitzpatrick, Eleanor, Kooda, Kirstin J., Biehl, Michelle, Dangayach, Neha S., Kaul, Viren, Chae, June M., Leppin, Aaron, Siuba, Mathew, Kashyap, Rahul, Walkey, Allan J., Niven, Alexander S., Martinez, Anthony, Meadows, Dean, Stinnett, Helen, Allison, Michael, Adeyemi, Olubukola, Herbert, Terry, Weinhouse, Gerald L., Patil, Namrata, Hacobian, Gaspar, Rangelov, Kamen, Parker, Jillian, Smith, Michael P., Smith, Rachel, Deery, Eliza, Harper, Andrea, Davis, Emily, Arteaga, Grace M., Fleegel, Jennifer L., Duncan, Julie M., Graner, Kevin K., Schultz, Tammy J., Giri, Abhishek, Gill, Ashley, Mielke, Catherine L., Sanghavi, Devang, Clark, Jonathan K., Shimp, Julie, Marshall, Lisa, Spiros, Michael, Kaur, Nirmaljot, Kiley, Sean P., Yarrarapu, Siva Naga, Keister, Teresa, Stroope, Gage, Stark, Jackie, Poehler, Jessica, Pablo, Juan, Garces, Domecq, Jain, Nitesh Kumar, Khan, Syed Anjum, Koritala, Thoyaja, La Nou, Abigail, Hall, Christina, Christensen, Cindy, Holbrook, Kirsten, Toufar, Sara, Normand, Sarah, Spitzner, Amy, Quinn, Carissa, Xia, Christina, Behrns, Holly D., Barreto, Erin, Elmer, Jennifer, Chalmers, Sarah, Cooper, Macy, Harthan, Aaron, Martinez, Edmundo A., Bandy, Jennifer A., Sanford, John, Guiliani, Jackie A., Kupferschmid, Megan, Pariyadath, Anand, Vitielliss, Brandy, Temas, Daniel, Heavner, Smith F., Frary, Amanda, Akhter, Murtaza, Rahman, Rania, Mulrow, Mary, Cooper, Tracy, Litell, John M., Chae, June Mee, Cawcutt, Kelly, Kooda, Kirstin J., Biehl, Michelle, Dangayach, Neha S., Redmond, Sarah, Kaul, Viren, Siuba, Matthew, Holley, Aaron B., Kon, Alexander A., Avadhani, Amita, Dzierba, Amy L., Kalil, Andre C., Cawcutt, Kelly, DePriest, Ashley D., Peters, Bradley, Pun, Brenda T., Bennett, Courtney E., Kriner, Eric, DeMartino, Erin S., Strong, Erin, Netzer, Giora, Martin, Greg S., Zimmerman, Jerry J., Taylor, Julia, Korzick, Karen A., Fischkoff, Katherine, Kaplan, Lewis J., Ostermann, Marlies, Gaeta, Mary Susan, Marshall, Mary Faith, Ahmed, Nahreen, Nyquist, Paul Alan, Nawathe, Pooja A., John, Preeti R., and Syed, Uzma

Published
2023
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16. 2023 Guideline for the Management of Patients With Aneurysmal Subarachnoid Hemorrhage: A Guideline From the American Heart Association/American Stroke Association

Author

Hoh, Brian L., Ko, Nerissa U., Amin-Hanjani, Sepideh, Hsiang-Yi Chou, Sherry, Cruz-Flores, Salvador, Dangayach, Neha S., Derdeyn, Colin P., Du, Rose, Hänggi, Daniel, Hetts, Steven W., Ifejika, Nneka L., Johnson, Regina, Keigher, Kiffon M., Leslie-Mazwi, Thabele M., Lucke-Wold, Brandon, Rabinstein, Alejandro A., Robicsek, Steven A., Stapleton, Christopher J., Suarez, Jose I., Tjoumakaris, Stavropoula I., and Welch, Babu G.

Published
2023
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17. Deferoxamine mesylate in patients with intracerebral haemorrhage (i-DEF): a multicentre, randomised, placebo-controlled, double-blind phase 2 trial

Author

Selim, Magdy, Foster, Lydia D, Moy, Claudia S, Xi, Guohua, Hill, Michael D, Morgenstern, Lewis B, Greenberg, Steven M, James, Michael L, Singh, Vineeta, Clark, Wayne M, Norton, Casey, Palesch, Yuko Y, Yeatts, Sharon D, Investigators, i-DEF, Dolan, Monica, Yeh, Erlinda, Sheth, Kevin, Kunze, Kimberly, Muehlschlegel, Susanne, Nieto, Iryna, Claassen, Jan, Falo, Cristina, Huang, David, Beckwith, Anne, Messe, Steven, Yates, Melissa, O'Phelan, Kristine, Escobar, Andrea, Becker, Kyra, Tanzi, Patricia, Gonzales, Nicole, Tremont, Chad, Venkatasubramanian, Chitra, Thiessen, Rosita, Save, Supriya, Verrault, Steven, Collard, Karin, DeGeorgia, Michael, Cwiklinski, Valerie, Thompson, Bradford, Wasilewski, Lesley, Andrews, Charles, Burfeind, Robert, Torbey, Michel, Hamed, Mohammad, Butcher, Kenneth, Sivakumar, Leka, Varelas, Nicolaou, Mays-Wilson, Kathleen, Leira, Enrique, Olalde, Heena, Silliman, Scott, Calhoun, Rhonda, Dangayach, Neha, Renvill, Ricardo, Malhotra, Rishi, Kordesch, Kristina, Lord, Aaron, Calahan, Thomas, Geocadin, Romergryko, Parish, Michelle, Frey, James, Harrigan, Mary, Leifer, Dana, Mathias, Ryna, Schneck, Michael, Bernier, Tara, Gonzales-Arias, Sergio, Elysee, Josette, Lopez, George, Volgi, Josephine, Brown, Robert, Jasak, Sara, Phillips, Stephen, Jarrett, Judith, Gomes, Joao, McBride, Moneen, Aldrich, Francois, Aldrich, Charlene, Kornbluth, Joshua, Bettle, Michelle, Goldstein, Joshua, Tirrell, Gregory, Shaw, Qaisar, and Jonczak, Karin

Subjects
Neurosciences, Clinical Research, Clinical Trials and Supportive Activities, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Aged, Cerebral Hemorrhage, Deferoxamine, Double-Blind Method, Female, Humans, Infusions, Intravenous, Iron Chelating Agents, Male, Medical Futility, Middle Aged, Negative Results, Prospective Studies, Risk Assessment, Treatment Outcome, i-DEF Investigators, Clinical Sciences, Neurology & Neurosurgery
Abstract

BackgroundIron from haemolysed blood is implicated in secondary injury after intracerebral haemorrhage. We aimed to assess the safety of the iron chelator deferoxamine mesylate in patients with intracerebral haemorrhage and to establish whether the drug merits investigation in a phase 3 trial.MethodsWe did a multicentre, futility-design, randomised, placebo-controlled, double-blind, phase 2 trial at 40 hospitals in Canada and the USA. Adults aged 18-80 years with primary, spontaneous, supratentorial intracerebral haemorrhage were randomly assigned (1:1) to receive deferoxamine mesylate (32 mg/kg per day) or placebo (saline) infusions for 3 consecutive days within 24 h of haemorrhage onset. Randomisation was done via a web-based trial-management system centrally in real time, and treatment allocation was concealed from both participants and investigators. The primary outcome was good clinical outcome, which was defined as a modified Rankin Scale score of 0-2 at day 90. We did a futility analysis: if the 90% upper confidence bound of the absolute risk difference between the two groups in the proportion of participants with a good clinical outcome was less than 12% in favour of deferoxamine mesylate, then to move to a phase 3 efficacy trial would be futile. Primary outcome and safety data were analysed in the modified intention-to-treat population, comprising only participants in whom the study infusions were initiated. This trial is registered with ClinicalTrials.gov, number NCT02175225, and is completed.FindingsWe recruited 294 participants between Nov 23, 2014, and Nov 10, 2017. The modified intention-to-treat population consisted of 144 patients assigned to the deferoxamine mesylate group and 147 assigned to the placebo group. At day 90, among patients with available data for the primary outcome, 48 (34%) of 140 participants in the deferoxamine mesylate group, and 47 (33%) of 143 patients in the placebo group, had modified Rankin Scale scores of 0-2 (adjusted absolute risk difference 0·6% [90% upper confidence bound 6·8%]). By day 90, 70 serious adverse events were reported in 39 (27%) of 144 patients in the deferoxamine mesylate group, and 78 serious adverse events were reported in 49 (33%) of 147 patients in the placebo group. Ten (7%) participants in the deferoxamine mesylate and 11 (7%) in the placebo group died. None of the deaths were judged to be treatment related.InterpretationDeferoxamine mesylate was safe. However, the primary result showed that further study of the efficacy of deferoxamine mesylate with anticipation that the drug would significantly improve the chance of good clinical outcome (ie, mRS score of 0-2) at day 90 would be futile.FundingUS National Institutes of Health and US National Institute of Neurological Disorders and Stroke.

Published
2019

20. Continuous Quality Improvement: Utilizing a Novel Education Platform to Enhance Care for the Caregiver in the Neurosciences Intensive Care Unit.

Author

Klavansky, Dana, Lehrer, Helaina, Levy, Ruth, Boahene-Nartey, Golda, Riley, Elka, and Dangayach, Neha S.

Subjects
PATIENT satisfaction, INTENSIVE care units, INTENSIVE care patients, FAMILY communication, PATIENTS' families
Abstract

Background: Timely patient and family communication is fundamental to the delivery of patient and family-centered care in the intensive care unit (ICU). However, repetitive, non-urgent communication with patients and designated patient contacts (DPCs) may lead to workflow disruptions, patient safety concerns and burnout. Implementing media-rich, educational content via a web-app could promote a more communication-friendly environment and reduce redundant communication. This may lower workflow disruptions and save time for more meaningful interactions with providers. The goal of this study was to deliver relevant, high-quality content via a web-app, assess time savings, and patient satisfaction with the web-app. Methods: A pre-implementation survey was distributed to Neurosciences intensive care unit (NSICU) staff to assess the burden of repetitive non-urgent communication and perceived duration of disruptions. Patients admitted to the NSICU from September 2022 to February 2023, n = 221 were included in the study. Patients were enrolled in the web-app. Patients and their DPC were granted access. Demographics including patient diagnosis, age, gender, and race were collected, along with data on weekly patient enrollment, number of DPCs granted access, total, frequency, and average view times of each piece of web-app content, and expected time saved due to review of web-app-based content by patient and/or DPCs to reduce repetitive communication by NSICU caregivers. The time saved for each piece of web-app content was calculated after getting feedback from providers (attendings, fellows, advanced practice providers, nurses) for how long it generally took them to convey each piece of information to patients and families. Results: Based on web-app content reviewed by patients and/or DPCs, the estimated average amount of NSICU caregiver time saved over the study period, based on application content views, was 82 min per week, and the cumulative total provider time saved for all content views was 26 h and 53 min. Twenty-one of 59 applications were rated by patients or their DPC and received five-star reviews (out of 5). Conclusion: The implementation of a web-app to facilitate and increase efficiency in communication leads to time savings for NSICU providers and patient/DPC satisfaction with the media-rich educational content. [ABSTRACT FROM AUTHOR]

Published
2025
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21. Standardizing Domains and Metrics of Stroke Recovery: A Systematic Review.

Author

Akkara, Yash, Afreen, Ryan, Lemonick, Michael, Paz, Santiago Gomez, Rifi, Ziad, Tosto, Jenna, Putrino, David, Mocco, J., Bederson, Joshua, Dangayach, Neha, and Kellner, Christopher P.

Subjects
HEMORRHAGIC stroke, ISCHEMIC stroke, STROKE rehabilitation, ACTIVITIES of daily living, QUALITY of life
Abstract

Background and Aims: Measuring stroke recovery poses a significant challenge, given the complexity of the recovery process. We aimed to identify a standardized and data-driven set of metrics of stroke rehabilitation in the literature that ensures the inclusion of all recovery domains and subdomains in the literature. Methods: A systematic review was conducted by four reviewers using the PRISMA guidelines on PubMed, MEDLINE, and Embase for stroke recovery articles between 2004 and 2024. The inclusion criteria comprised experimental/observational studies, including ischemic and hemorrhagic stroke. All studies had ≥20 participants who were ≥18 years of age, and had a follow-up of ≥3 months. Outcomes included demographics, geographic origin, stroke mechanism, domains and subdomains, metrics used, and follow-up. A bias assessment was performed using the Newcastle-Ottawa Scale and the Cochrane Risk of Bias 2.0 tool. This study was registered with PROSPERO (CRD42024551753). Results: Our search included 324 studies with a sample of 85,156 participants. The study identified seven domains (perception, physical and motor function (PF), speech and language (S&L), cognition, activities of daily living (ADL), quality of life (QoL), and social interaction) and 96 constituent subdomains that encompass the complete landscape of the stroke recovery literature identified. The domains of PF and ADL constituted the vast share of the literature, albeit reducing in their relative representation over time, while domains such as perception and QoL have been increasingly studied since 2004. Using the domains, the study identified the set and frequency of all commonly used metrics to measure stroke recovery in the literature, of which the NIHSS (n = 72), BI (n = 55), and mRS (n = 51) were the most commonly used. We identified eighteen standard metrics that ensure the inclusion of all seven domains and 96 subdomains. Summary of Review and Conclusions: The identified set of domains and metrics within this study can help inform further clinical research and decision-making by providing a standardized set of metrics to be used for each domain. This approach ensures lesser represented domains and subdomains are also included during testing, providing a more complete view and measure of stroke recovery. [ABSTRACT FROM AUTHOR]

Published
2024
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27. What Makes a Tweetorial Fly? (S33.009)

Author

Albin, Casey, primary, Pucci, Gabriela, additional, Zelikovich, Aaron, additional, Lawson, Eric, additional, Ma, Tianwen, additional, Sarwal, Aarti, additional, Dangayach, Neha, additional, Berkowitz, Aaron, additional, Morris, Nicholas, additional, and Jones, Lyell, additional

Published
2024
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29. Research considerations for prospective studies of patients with coma and disorders of consciousness

Author

Tinti, L, Lawson, T, Molteni, E, Kondziella, D, Rass, V, Sharshar, T, Bodien, Y, Giacino, J, Mayer, S, Amiri, M, Muehlschlegel, S, Venkatasubba Rao, C, Vespa, P, Menon, D, Citerio, G, Helbok, R, Mcnett, M, Agarwal, S, Aiyagari, V, Akbari, Y, Albertson, A, Alexander, S, Alexandrov, A, Alkhachroum, A, Al-Mufti, F, Appavu, B, Gebrewold, M, Ayounb, M, Badenes, R, Bader, M, Badjiata, N, Balu, R, Barlow, B, Barra, M, Beekman, R, Beghi, E, Beqiri, E, Berlin, T, Bilotta, F, Bleck, T, Boerwinkle, V, Boly, M, Bonnel, A, Brazzi, L, Brown, E, Bulic, S, Caceres, E, Caceres, A, Cafiero, T, Carroll, E, Cediel, E, Chou, S, Claassen, J, Condie, C, Conti, A, Cosmas, K, Costa, P, Creutzfeldt, C, Dangayach, N, Dauri, M, Debicki, D, Degeorgia, M, Der-Nigoghossian, C, Desai, M, Dhar, R, Diringer, M, Durr, E, Edlow, B, Ercole, A, Estraneo, A, Falcone, G, Farrokh, S, Ferguson, A, Fernandez-Espejo, D, Fink, E, Fins, J, Foreman, B, Franchi, F, Frontera, J, Ganesan, R, Gaspard, N, Ghavam, A, Gibbons, C, Gilmore, E, Glustein, C, Gosseries, O, Green, T, Greer, D, Guanci, M, Gupta, D, Hahn, C, Hakimi, R, Hammond, F, Hanley, D, Hartings, J, Hassan, A, Hemphill, C, Da Cunha, A, Hinson, H, Hirsch, K, Hocker, S, Hu, P, Hu, X, Human, T, Hwang, D, Illes, J, Jaffa, M, James, M, Janas, A, Johnson, S, Jones, M, Jox, R, Kalanuria, A, Keller, E, Kennedy, L, Kennelly, M, Keogh, M, Kim, J, Kim, K, Kirsch, H, Kirschen, M, Ko, N, Kreitzer, N, Kromm, J, Kumar, A, Kurtz, P, Laureys, S, Lejeune, N, Lewis, A, Liang, J, Ling, G, Livesay, S, Luppi, A, Macdonald, J, Maddux, C, Mahanes, D, Mainali, S, Maldonado, N, Ribeiro, R, Mascia, L, Massimini, M, Mathur, R, Mccredie, V, Mejia-Mantilla, J, Mendoza, M, Meyfroidt, G, Mijangos, J, Moberg, D, Moheet, A, Montalenti, E, Monti, M, Morrison, C, Munar, M, Murtaugh, B, Naccache, L, Nagayama, M, Nairon, E, Nakagawa, T, Naldi, A, Narenthiran, G, Natarajan, G, Nemetsky, E, Newcombe, V, Nielsen, N, Niznick, N, Noronha-Falcão, F, Nyquist, P, Olson, D, Othman, M, Owen, A, Padayachy, L, Pajoumand, M, Park, S, Pergakis, M, Perry, H, Polizzotto, L, Pouratian, N, Spivack, M, Prisco, L, Provencio, J, Puglises, F, Puybasset, L, Rao, C, Rasmussen, L, Rasulo, F, Ray, B, Ricci, Z, Richardson, R, Shinotsuka, C, Robba, C, Robertson, C, Rohaut, B, Rolston, J, Romagnoli, S, Rosanova, M, Rosenthal, E, Rowe, S, Rubin, M, Russell, M, Silva, G, Sanz, L, Sarasso, S, Sarwal, A, Schiff, N, Schnakers, C, Seder, D, Shah, V, Shapiro-Rosenbaubm, A, Shapshak, A, Sharma, K, Shutter, L, Sitt, J, Slomine, B, Smetana, K, Smielewski, P, Smith, W, Stamatakis, E, Steinberg, A, Stevens, R, Suarez, J, Sung, G, Sussman, B, Taran, S, Mazzeo, A, Thibaut, A, Thompson, D, Threlkeld, Z, Toker, D, Torbey, M, Tosto, J, Trevick, S, Tsaousi, G, Turgeon, A, Udy, A, Varelas, P, Videtta, W, Voss, H, Vox, F, Wagner, A, Wahlster, S, Wainwright, M, Whyte, J, Witherspoon, B, Yakhkind, A, Yeager, S, Young, M, Zafar, S, Zafonte, R, Zahuranec, D, Zammit, C, Zhang, B, Ziai, W, Zimmerman, L, Zink, E, Tinti, Lorenzo, Lawson, Thomas, Molteni, Erika, Kondziella, Daniel, Rass, Verena, Sharshar, Tarek, Bodien, Yelena G, Giacino, Joseph T, Mayer, Stephan A, Amiri, Moshgan, Muehlschlegel, Susanne, Venkatasubba Rao, Chethan P, Vespa, Paul M, Menon, David K, Citerio, Giuseppe, Helbok, Raimund, McNett, Molly, Agarwal, Sachin, Aiyagari, Venkatesh, Akbari, Yama, Albertson, Asher, Alexander, Sheila, Alexandrov, Anne, Alkhachroum, Ayham, Al-Mufti, Fawaz, Amiri, Moshagan, Appavu, Brian, Gebrewold, Meron Awraris, Ayounb, Marc, Badenes, Rafael, Bader, Mary Kay, Badjiata, Neeraj, Balu, Ram, Barlow, Brooke, Barra, Megan, Beekman, Rachel, Beghi, Ettore, Beqiri, Erta, Berlin, Tracey, Bilotta, Federico, Bleck, Thomas, Bodien, Yelena, Boerwinkle, Varina, Boly, Melanie, Bonnel, Alexandra, Brazzi, Luca, Brown, Emery, Bulic, Sebina, Caceres, Eder, Caceres, Adrian, Cafiero, Tullio, Carroll, Elizabeth, Cediel, Emilio G, Chou, Sherry, Claassen, Jan, Condie, Chad, Conti, Alfredo, Cosmas, Katie, Costa, Paolo, Creutzfeldt, Claire, Dangayach, Neha, Dauri, Mario, Debicki, Derek, DeGeorgia, Michael, Der-Nigoghossian, Caroline, Desai, Masoom, Dhar, Rajat, Diringer, Michael, Durr, Emily, Edlow, Brian, Ercole, Ari, Estraneo, Anna, Falcone, Guido, Farrokh, Salia, Ferguson, Adam, Fernandez-Espejo, Davinia, Fink, Ericka, Fins, Joseph, Foreman, Brandon, Franchi, Federico, Frontera, Jennifer, Ganesan, Rishi, Gaspard, Nicolas, Ghavam, Ahmeneh, Giacino, Joseph, Gibbons, Christie, Gilmore, Emily, Glustein, Chavie, Gosseries, Olivia, Green, Theresa, Greer, David, Guanci, Mary, Gupta, Deepak, Hahn, Cecil, Hakimi, Ryan, Hammond, Flora, Hanley, Daniel F, Hartings, Jed, Hassan, Ahmed, Hemphill, Claude, Da Cunha, Arthur Henrique Galvão Bruno, Hinson, Holly, Hirsch, Karen, Hocker, Sarah, Hu, Peter, Hu, Xiao, Human, Theresa, Hwang, David, Illes, Judy, Jaffa, Matthew, James, Michael L, Janas, Anna, Johnson, Susan, Jones, Morgan, Jox, Ralf J, Kalanuria, Atul, Keller, Emanuela, Kennedy, Lori, Kennelly, Megan, Keogh, Maggie, Kim, Jenn, Kim, Keri, Kirsch, Hannah, Kirschen, Matthew, Ko, Nerissa, Kreitzer, Natalie, Kromm, Julie, Kumar, Abhay, Kurtz, Pedro, Laureys, Steven, Lejeune, Nicolas, Lewis, Ariane, Liang, John, Ling, Geoffrey, Livesay, Sarah, Luppi, Andrea, MacDonald, Jennifer, Maddux, Craig, Mahanes, Dea, Mainali, Shraddha, Maldonado, Nelson, Ribeiro, Rennan Martins, Mascia, Luciana, Massimini, Marcello, Mathur, Rohan, Mayer, Stephan, McCredie, Victoria, Mejia-Mantilla, Jorge, Mendoza, Michael, Menon, David, Meyfroidt, Geert, Mijangos, Julio, Moberg, Dick, Moheet, Asma, Montalenti, Elisa, Monti, Martin, Morrison, Chris, Munar, Marina, Murtaugh, Brooke, Naccache, Lionel, Nagayama, Masao, Nairon, Emerson, Nakagawa, Thomas, Naldi, Andrea, Narenthiran, Ganesalingam, Natarajan, Girija, Nemetsky, Esther, Newcombe, Virginia, Nielsen, Niklas, Niznick, Naomi, Noronha-Falcão, Filipa, Nyquist, Paul, Olson, DaiWai, Othman, Marwan, Owen, Adrian, Padayachy, Llewellyn, Pajoumand, Mehrnaz, Park, Soojin, Pergakis, Melissa, Perry, Heidi, Polizzotto, Len, Pouratian, Nader, Spivack, Marilyn Price, Prisco, Lara, Provencio, Javier, Puglises, Francesco, Puybasset, Louis, Rao, Chethan, Rasmussen, Lindsay, Rasulo, Frank, Ray, Bappaditya, Ricci, Zaccaria, Richardson, Risa, Shinotsuka, Cassia Righy, Robba, Chiara, Robertson, Courtney, Rohaut, Benjamin, Rolston, John, Romagnoli, Stefano, Rosanova, Mario, Rosenthal, Eric, Rowe, Shaun, Rubin, Michael, Russell, Mary Beth, Silva, Gisele Sampaio, Sanz, Leandro, Sarasso, Simone, Sarwal, Aarti, Schiff, Nicolas, Schnakers, Caroline, Seder, David, Shah, Vishank Arun, Shapiro-Rosenbaubm, Amy, Shapshak, Angela, Sharma, Kartavya, Sharma, Kumar Ajay, Shutter, Lori, Sitt, Jacobo, Slomine, Beth, Smetana, Keaton, Smielewski, Peter, Smith, Wade, Stamatakis, Emmanuel, Steinberg, Alexis, Stevens, Robert, Suarez, Jose, Sung, Gene, Sussman, Bethany, Taran, Shaurya, Mazzeo, Anna Teresa, Thibaut, Aurore, Thompson, David, Threlkeld, Zachary, Toker, Daniel, Torbey, Michel, Tosto, Jenna, Trevick, Stephen, Tsaousi, Georgia, Turgeon, Alexis, Udy, Andrew, Varelas, Panos, Vespa, Paul, Videtta, Walter, Voss, Henning, Vox, Ford, Wagner, Amy, Wahlster, Sarah, Wainwright, Mark, Whyte, John, Witherspoon, Briana, Yakhkind, Aleksandra (Sasha), Yeager, Susan, Young, Michael, Zafar, Sahar, Zafonte, Ross, Zahuranec, Darin, Zammit, Chris, Zhang, Bei, Ziai, Wendy, Zimmerman, Lara, Zink, Elizabeth, Tinti, L, Lawson, T, Molteni, E, Kondziella, D, Rass, V, Sharshar, T, Bodien, Y, Giacino, J, Mayer, S, Amiri, M, Muehlschlegel, S, Venkatasubba Rao, C, Vespa, P, Menon, D, Citerio, G, Helbok, R, Mcnett, M, Agarwal, S, Aiyagari, V, Akbari, Y, Albertson, A, Alexander, S, Alexandrov, A, Alkhachroum, A, Al-Mufti, F, Appavu, B, Gebrewold, M, Ayounb, M, Badenes, R, Bader, M, Badjiata, N, Balu, R, Barlow, B, Barra, M, Beekman, R, Beghi, E, Beqiri, E, Berlin, T, Bilotta, F, Bleck, T, Boerwinkle, V, Boly, M, Bonnel, A, Brazzi, L, Brown, E, Bulic, S, Caceres, E, Caceres, A, Cafiero, T, Carroll, E, Cediel, E, Chou, S, Claassen, J, Condie, C, Conti, A, Cosmas, K, Costa, P, Creutzfeldt, C, Dangayach, N, Dauri, M, Debicki, D, Degeorgia, M, Der-Nigoghossian, C, Desai, M, Dhar, R, Diringer, M, Durr, E, Edlow, B, Ercole, A, Estraneo, A, Falcone, G, Farrokh, S, Ferguson, A, Fernandez-Espejo, D, Fink, E, Fins, J, Foreman, B, Franchi, F, Frontera, J, Ganesan, R, Gaspard, N, Ghavam, A, Gibbons, C, Gilmore, E, Glustein, C, Gosseries, O, Green, T, Greer, D, Guanci, M, Gupta, D, Hahn, C, Hakimi, R, Hammond, F, Hanley, D, Hartings, J, Hassan, A, Hemphill, C, Da Cunha, A, Hinson, H, Hirsch, K, Hocker, S, Hu, P, Hu, X, Human, T, Hwang, D, Illes, J, Jaffa, M, James, M, Janas, A, Johnson, S, Jones, M, Jox, R, Kalanuria, A, Keller, E, Kennedy, L, Kennelly, M, Keogh, M, Kim, J, Kim, K, Kirsch, H, Kirschen, M, Ko, N, Kreitzer, N, Kromm, J, Kumar, A, Kurtz, P, Laureys, S, Lejeune, N, Lewis, A, Liang, J, Ling, G, Livesay, S, Luppi, A, Macdonald, J, Maddux, C, Mahanes, D, Mainali, S, Maldonado, N, Ribeiro, R, Mascia, L, Massimini, M, Mathur, R, Mccredie, V, Mejia-Mantilla, J, Mendoza, M, Meyfroidt, G, Mijangos, J, Moberg, D, Moheet, A, Montalenti, E, Monti, M, Morrison, C, Munar, M, Murtaugh, B, Naccache, L, Nagayama, M, Nairon, E, Nakagawa, T, Naldi, A, Narenthiran, G, Natarajan, G, Nemetsky, E, Newcombe, V, Nielsen, N, Niznick, N, Noronha-Falcão, F, Nyquist, P, Olson, D, Othman, M, Owen, A, Padayachy, L, Pajoumand, M, Park, S, Pergakis, M, Perry, H, Polizzotto, L, Pouratian, N, Spivack, M, Prisco, L, Provencio, J, Puglises, F, Puybasset, L, Rao, C, Rasmussen, L, Rasulo, F, Ray, B, Ricci, Z, Richardson, R, Shinotsuka, C, Robba, C, Robertson, C, Rohaut, B, Rolston, J, Romagnoli, S, Rosanova, M, Rosenthal, E, Rowe, S, Rubin, M, Russell, M, Silva, G, Sanz, L, Sarasso, S, Sarwal, A, Schiff, N, Schnakers, C, Seder, D, Shah, V, Shapiro-Rosenbaubm, A, Shapshak, A, Sharma, K, Shutter, L, Sitt, J, Slomine, B, Smetana, K, Smielewski, P, Smith, W, Stamatakis, E, Steinberg, A, Stevens, R, Suarez, J, Sung, G, Sussman, B, Taran, S, Mazzeo, A, Thibaut, A, Thompson, D, Threlkeld, Z, Toker, D, Torbey, M, Tosto, J, Trevick, S, Tsaousi, G, Turgeon, A, Udy, A, Varelas, P, Videtta, W, Voss, H, Vox, F, Wagner, A, Wahlster, S, Wainwright, M, Whyte, J, Witherspoon, B, Yakhkind, A, Yeager, S, Young, M, Zafar, S, Zafonte, R, Zahuranec, D, Zammit, C, Zhang, B, Ziai, W, Zimmerman, L, Zink, E, Tinti, Lorenzo, Lawson, Thomas, Molteni, Erika, Kondziella, Daniel, Rass, Verena, Sharshar, Tarek, Bodien, Yelena G, Giacino, Joseph T, Mayer, Stephan A, Amiri, Moshgan, Muehlschlegel, Susanne, Venkatasubba Rao, Chethan P, Vespa, Paul M, Menon, David K, Citerio, Giuseppe, Helbok, Raimund, McNett, Molly, Agarwal, Sachin, Aiyagari, Venkatesh, Akbari, Yama, Albertson, Asher, Alexander, Sheila, Alexandrov, Anne, Alkhachroum, Ayham, Al-Mufti, Fawaz, Amiri, Moshagan, Appavu, Brian, Gebrewold, Meron Awraris, Ayounb, Marc, Badenes, Rafael, Bader, Mary Kay, Badjiata, Neeraj, Balu, Ram, Barlow, Brooke, Barra, Megan, Beekman, Rachel, Beghi, Ettore, Beqiri, Erta, Berlin, Tracey, Bilotta, Federico, Bleck, Thomas, Bodien, Yelena, Boerwinkle, Varina, Boly, Melanie, Bonnel, Alexandra, Brazzi, Luca, Brown, Emery, Bulic, Sebina, Caceres, Eder, Caceres, Adrian, Cafiero, Tullio, Carroll, Elizabeth, Cediel, Emilio G, Chou, Sherry, Claassen, Jan, Condie, Chad, Conti, Alfredo, Cosmas, Katie, Costa, Paolo, Creutzfeldt, Claire, Dangayach, Neha, Dauri, Mario, Debicki, Derek, DeGeorgia, Michael, Der-Nigoghossian, Caroline, Desai, Masoom, Dhar, Rajat, Diringer, Michael, Durr, Emily, Edlow, Brian, Ercole, Ari, Estraneo, Anna, Falcone, Guido, Farrokh, Salia, Ferguson, Adam, Fernandez-Espejo, Davinia, Fink, Ericka, Fins, Joseph, Foreman, Brandon, Franchi, Federico, Frontera, Jennifer, Ganesan, Rishi, Gaspard, Nicolas, Ghavam, Ahmeneh, Giacino, Joseph, Gibbons, Christie, Gilmore, Emily, Glustein, Chavie, Gosseries, Olivia, Green, Theresa, Greer, David, Guanci, Mary, Gupta, Deepak, Hahn, Cecil, Hakimi, Ryan, Hammond, Flora, Hanley, Daniel F, Hartings, Jed, Hassan, Ahmed, Hemphill, Claude, Da Cunha, Arthur Henrique Galvão Bruno, Hinson, Holly, Hirsch, Karen, Hocker, Sarah, Hu, Peter, Hu, Xiao, Human, Theresa, Hwang, David, Illes, Judy, Jaffa, Matthew, James, Michael L, Janas, Anna, Johnson, Susan, Jones, Morgan, Jox, Ralf J, Kalanuria, Atul, Keller, Emanuela, Kennedy, Lori, Kennelly, Megan, Keogh, Maggie, Kim, Jenn, Kim, Keri, Kirsch, Hannah, Kirschen, Matthew, Ko, Nerissa, Kreitzer, Natalie, Kromm, Julie, Kumar, Abhay, Kurtz, Pedro, Laureys, Steven, Lejeune, Nicolas, Lewis, Ariane, Liang, John, Ling, Geoffrey, Livesay, Sarah, Luppi, Andrea, MacDonald, Jennifer, Maddux, Craig, Mahanes, Dea, Mainali, Shraddha, Maldonado, Nelson, Ribeiro, Rennan Martins, Mascia, Luciana, Massimini, Marcello, Mathur, Rohan, Mayer, Stephan, McCredie, Victoria, Mejia-Mantilla, Jorge, Mendoza, Michael, Menon, David, Meyfroidt, Geert, Mijangos, Julio, Moberg, Dick, Moheet, Asma, Montalenti, Elisa, Monti, Martin, Morrison, Chris, Munar, Marina, Murtaugh, Brooke, Naccache, Lionel, Nagayama, Masao, Nairon, Emerson, Nakagawa, Thomas, Naldi, Andrea, Narenthiran, Ganesalingam, Natarajan, Girija, Nemetsky, Esther, Newcombe, Virginia, Nielsen, Niklas, Niznick, Naomi, Noronha-Falcão, Filipa, Nyquist, Paul, Olson, DaiWai, Othman, Marwan, Owen, Adrian, Padayachy, Llewellyn, Pajoumand, Mehrnaz, Park, Soojin, Pergakis, Melissa, Perry, Heidi, Polizzotto, Len, Pouratian, Nader, Spivack, Marilyn Price, Prisco, Lara, Provencio, Javier, Puglises, Francesco, Puybasset, Louis, Rao, Chethan, Rasmussen, Lindsay, Rasulo, Frank, Ray, Bappaditya, Ricci, Zaccaria, Richardson, Risa, Shinotsuka, Cassia Righy, Robba, Chiara, Robertson, Courtney, Rohaut, Benjamin, Rolston, John, Romagnoli, Stefano, Rosanova, Mario, Rosenthal, Eric, Rowe, Shaun, Rubin, Michael, Russell, Mary Beth, Silva, Gisele Sampaio, Sanz, Leandro, Sarasso, Simone, Sarwal, Aarti, Schiff, Nicolas, Schnakers, Caroline, Seder, David, Shah, Vishank Arun, Shapiro-Rosenbaubm, Amy, Shapshak, Angela, Sharma, Kartavya, Sharma, Kumar Ajay, Shutter, Lori, Sitt, Jacobo, Slomine, Beth, Smetana, Keaton, Smielewski, Peter, Smith, Wade, Stamatakis, Emmanuel, Steinberg, Alexis, Stevens, Robert, Suarez, Jose, Sung, Gene, Sussman, Bethany, Taran, Shaurya, Mazzeo, Anna Teresa, Thibaut, Aurore, Thompson, David, Threlkeld, Zachary, Toker, Daniel, Torbey, Michel, Tosto, Jenna, Trevick, Stephen, Tsaousi, Georgia, Turgeon, Alexis, Udy, Andrew, Varelas, Panos, Vespa, Paul, Videtta, Walter, Voss, Henning, Vox, Ford, Wagner, Amy, Wahlster, Sarah, Wainwright, Mark, Whyte, John, Witherspoon, Briana, Yakhkind, Aleksandra (Sasha), Yeager, Susan, Young, Michael, Zafar, Sahar, Zafonte, Ross, Zahuranec, Darin, Zammit, Chris, Zhang, Bei, Ziai, Wendy, Zimmerman, Lara, and Zink, Elizabeth

Abstract

Disorders of consciousness are neurological conditions characterized by impaired arousal and awareness of self and environment. Behavioural responses are absent or are present but fluctuate. Disorders of consciousness are commonly encountered as a consequence of both acute and chronic brain injuries, yet reliable epidemiological estimates would require inclusive, operational definitions of the concept, as well as wider knowledge dissemination among involved professionals. Whereas several manifestations have been described, including coma, vegetative state/unresponsive wakefulness syndrome and minimally conscious state, a comprehensive neurobiological definition for disorders of consciousness is still lacking. The scientific literature is primarily observational, and studies-specific aetiologies lead to disorders of consciousness. Despite advances in these disease-related forms, there remains uncertainty about whether disorders of consciousness are a disease-agnostic unitary entity with a common mechanism, prognosis or treatment response paradigm. Our knowledge of disorders of consciousness has also been hampered by heterogeneity of study designs, variables, and outcomes, leading to results that are not comparable for evidence synthesis. The different backgrounds of professionals caring for patients with disorders of consciousness and the different goals at different stages of care could partly explain this variability. The Prospective Studies working group of the Neurocritical Care Society Curing Coma Campaign was established to create a platform for observational studies and future clinical trials on disorders of consciousness and coma across the continuum of care. In this narrative review, the author panel presents limitations of prior observational clinical research and outlines practical considerations for future investigations. A narrative review format was selected to ensure that the full breadth of study design considerations could be addressed and to facilit

Published
2024

34. Deferoxamine mesylate in patients with intracerebral haemorrhage (i-DEF): a multicentre, randomised, placebo-controlled, double-blind phase 2 trial

Author

Dolan, Monica, Yeh, Erlinda, Sheth, Kevin, Kunze, Kimberly, Muehlschlegel, Susanne, Nieto, Iryna, Claassen, Jan, Falo, Cristina, Huang, David, Beckwith, Anne, Messe, Steven, Yates, Melissa, O'Phelan, Kristine, Escobar, Andrea, Becker, Kyra, Tanzi, Patricia, Gonzales, Nicole, Tremont, Chad, Venkatasubramanian, Chitra, Thiessen, Rosita, Save, Supriya, Verrault, Steven, Collard, Karin, DeGeorgia, Michael, Cwiklinski, Valerie, Thompson, Bradford, Wasilewski, Lesley, Andrews, Charles, Burfeind, Robert, Torbey, Michel, Hamed, Mohammad, Butcher, Kenneth, Sivakumar, Leka, Varelas, Nicolaou, Mays-Wilson, Kathleen, Leira, Enrique, Olalde, Heena, Silliman, Scott, Calhoun, Rhonda, Dangayach, Neha, Renvill, Ricardo, Malhotra, Rishi, Kordesch, Kristina, Lord, Aaron, Calahan, Thomas, Geocadin, Romergryko, Parish, Michelle, Frey, James, Harrigan, Mary, Leifer, Dana, Mathias, Ryna, Schneck, Michael, Bernier, Tara, Gonzales-Arias, Sergio, Elysee, Josette, Lopez, George, Volgi, Josephine, Brown, Robert, Jasak, Sara, Phillips, Stephen, Jarrett, Judith, Gomes, Joao, McBride, Moneen, Aldrich, Francois, Aldrich, Charlene, Kornbluth, Joshua, Bettle, Michelle, Goldstein, Joshua, Tirrell, Gregory, Shaw, Qaisar, Jonczak, Karin, Selim, Magdy, Foster, Lydia D, Moy, Claudia S, Xi, Guohua, Hill, Michael D, Morgenstern, Lewis B, Greenberg, Steven M, James, Michael L, Singh, Vineeta, Clark, Wayne M, Norton, Casey, Palesch, Yuko Y, and Yeatts, Sharon D

Published
2019
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36. Derivation, External Validation and Clinical Implications of a deep learning approach for intracranial pressure estimation using non-cranial waveform measurements

Author

Gulamali, Faris, primary, Jayaraman, Pushkala, additional, Sawant, Ashwin S., additional, Desman, Jacob, additional, Fox, Benjamin, additional, Chang, Annie, additional, Soong, Brian Y., additional, Arivazaghan, Naveen, additional, Reynolds, Alexandra S., additional, Duong, Son Q, additional, Vaid, Akhil, additional, Kovatch, Patricia, additional, Freeman, Robert, additional, Hofer, Ira S., additional, Sakhuja, Ankit, additional, Dangayach, Neha S., additional, Reich, David S., additional, Charney, Alexander W, additional, and Nadkarni, Girish N., additional

Published
2024
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38. Post–Intensive Care Syndrome in Neurocritical Care Patients.

Author

Dangayach, Neha S., Kreitzer, Natalie, Foreman, Brandon, and Tosto-Mancuso, Jenna

Subjects
*INTENSIVE care units, *NEUROLOGICAL intensive care, *CAREGIVERS, *PHYSICAL mobility, *PATIENT care
Abstract

Post–intensive care syndrome (PICS) refers to unintended consequences of critical care that manifest as new or worsening impairments in physical functioning, cognitive ability, or mental health. As intensive care unit (ICU) survival continues to improve, PICS is becoming increasingly recognized as a public health problem. Studies that focus on PICS have typically excluded patients with acute brain injuries and chronic neurodegenerative problems. However, patients who require neurocritical care undoubtedly suffer from impairments that overlap substantially with those encompassed by PICS. A major challenge is to distinguish between impairments related to brain injury and those that occur as a consequence of critical care. The general principles for the prevention and management of PICS and multidomain impairments in patients with moderate and severe neurological injuries are similar including the ICU liberation bundle, multidisciplinary team-based care throughout the continuum of care, and increasing awareness regarding the challenges of critical care survivorship among patients, families, and multidisciplinary team members. An extension of this concept, PICS-Family (PICS-F) refers to the mental health consequences of the intensive care experience for families and loved ones of ICU survivors. A dyadic approach to ICU survivorship with an emphasis on recognizing families and caregivers that may be at risk of developing PICS-F after neurocritical care illness can help improve outcomes for ICU survivors. In this review, we will summarize our current understanding of PICS and PICS-F, emerging literature on PICS in severe acute brain injury, strategies for preventing and treating PICS, and share our recommendations for future directions. [ABSTRACT FROM AUTHOR]

Published
2024
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44. Mobile Interventional Stroke Team Model Improves Early Outcomes in Large Vessel Occlusion Stroke: The NYC MIST Trial

Author

Morey, Jacob R., Oxley, Thomas J., Wei, Daniel, Kellner, Christopher P., Dangayach, Neha S., Stein, Laura, Hom, Danny, Wheelwright, Danielle, Rubenstein, Liorah, Skliut, Maryna, Shoirah, Hazem, De Leacy, Reade A., Singh, I. Paul, Zhang, Xiangnan, Persaud, Steven, Tuhrim, Stanley, Dhamoon, Mandip, Bederson, Joshua, Mocco, J, and Fifi, Johanna T.

Published
2020
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46. Importance of Reconnection With ICU Survivors to ICU Recovery Program Clinicians

Author

Eaton, Tammy L., primary, Danesh, Valerie, additional, Sevin, Carla M., additional, Potter, Kelly, additional, Su, Han, additional, Iwashyna, Theodore J., additional, Boehm, Leanne M., additional, McPeake, Joanne, additional, Bernstein, Taylor, additional, Bakhru, Rita N., additional, Baram, Michael, additional, Biehl, Michelle, additional, Bellinghausen, Amy L., additional, Boyd, J. Gordon, additional, Butcher, Brad W., additional, Dalton, Melanie, additional, Dangayach, Neha S., additional, Enfield, Kyle B., additional, Hoehn, K. Sarah, additional, Hope, Aluko A., additional, Hornstein, David, additional, Jagpal, Sugeet, additional, Jolley, Sarah E., additional, Khan, Babar A., additional, Kenes, Michael T., additional, Kloos, Janet, additional, Korzick, Karen A., additional, Lief, Lindsay, additional, Mahoney, Eric, additional, Maley, Jason H., additional, Mayer, Kirby P., additional, McNeal, Tresa, additional, McSparron, Jakob I., additional, Meyer, Joel, additional, Mohammad, Rima A., additional, Montgomery-Yates, Ashley, additional, Nomellini, Vanessa, additional, Parker, Ann M., additional, Popovich, Kehllee, additional, Poyant, Janelle, additional, Quasim, Tara, additional, Saft, Howard, additional, Santhosh, Lekshmi, additional, Schwab, Kristin, additional, Slack, Andrew, additional, Stollings, Joanna L., additional, Sousa, David, additional, Torbic, Heather, additional, Valley, Thomas S., additional, and Villalba, Dario, additional

Published
2023
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47. Curriculum Innovations: A Social Media–Based Educational Curriculum Improves Knowledge for Trainees in Neurocritical Care

Author

Alvarado-Dyer, Ronald, primary, Saleh Velez, Faddi G., additional, Kamdar, Hera A., additional, Niznick, Naomi, additional, Carroll, Elizabeth, additional, Castillo-Pinto, Carlos, additional, Parasram, Melvin, additional, Kelly, Dearbhla, additional, Goswami, Shweta, additional, Ehntholt, Mikel S., additional, Dangayach, Neha S., additional, Babi, Marc-Alain, additional, Ramadan, Ahmad Riad, additional, Lazaridis, Christos, additional, Albin, Catherine, additional, and Morris, Nicholas A., additional

Published
2023
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