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This paper is devoted to the design, description and validation of the Android application TEAtreves, which focuses on structured arithmetic problem-solving for students with autism spectrum disorder (ASD). The application contains multiple adaptations to make it suitable for users with ASD. Validation was carried out with five students with ASD, obtaining positive results which confirm the strength of TEAtreves app for users with ASD. Results and future lines of work are discussed.

Abstract Ocean warming and acidification, decreases in dissolved oxygen concentrations, and changes in primary production are causing an unprecedented global redistribution of marine life. The identification of underlying ecological processes underpinning marine species turnover, particularly the prevalence of increases of warm-water species or declines of cold-water species, has been recently debated in the context of ocean warming. Here, we track changes in the mean thermal affinity of marine communities across European seas by calculating the Community Temperature Index for 65 biodiversity time series collected over four decades and containing 1,817 species from different communities (zooplankton, coastal benthos, pelagic and demersal invertebrates and fish). We show that most communities and sites have clearly responded to ongoing ocean warming via abundance increases of warm-water species (tropicalization, 54%) and decreases of cold-water species (deborealization, 18%). Tropicalization dominated Atlantic sites compared to semi-enclosed basins such as the Mediterranean and Baltic Seas, probably due to physical barrier constraints to connectivity and species colonization. Semi-enclosed basins appeared to be particularly vulnerable to ocean warming, experiencing the fastest rates of warming and biodiversity loss through deborealization.

Abstract Intermediate magma compositions have been postulated to be parental to Andean-type magmatism in the recent years. Geochemical and experimental methods have allowed the modelling of a hypothetical parental composition that accounts for the major element trends displayed by Andean-type batholiths. However, natural plutonic examples matching the modelled composition remain lacking, likely due to the predominance of fractionated liquids and cumulates in the batholiths after protracted and large-scale differentiation. Contrary to this, magma mingling zones, a common feature in Andean-type batholiths, are characterised by quenching phenomena, minimising differentiation. In this paper, we present data from intermediate magmatism in the world-class Gerena magma mingling zone in the Seville Sierra Norte batholith (southern Iberia), compositionally equivalent to Andean-type magmatic series. Geochemical data from quenched dark globules of variable scale and the corresponding host granodiorites are contrasted with the bimodal trends displayed by the host batholith. Results suggest that the smaller-scale dark globules have not undergone any significant fractionation. Furthermore, after conducting geochemical modelling we conclude the dark globules represent a composition that could be parental to Andean-type magmas. We propose that magma mingling zones are an optimal place to probe for parental magmas of Andean-type magmatism, particularly those represented in pristine melanocratic, intermediate globules.

Book Review

Abstract Thin films of antimony chalcogenides, Sb2X3 (X = S, Se, or SxSe1−x), comprised of (001) oriented nanorods are highly desirable for optoelectronic applications owing to their light trapping capacity and highly efficient charge transport along the optimally aligned quasi‐1D (Sb4X6)n ribbons. Here, highly (001) oriented Sb2Se3 nanorod (Sb2Se3NR) layers are obtained via a novel template growth method, and transfer these layers to functional substrates via a polymer‐assisted technique. Transferable layers overcome the current challenges associated with achieving oriented growth directly on the desired substrate. Using a combination of a low‐temperature processable SnO2 nanoparticle transport layer and encapsulation/etching techniques photodetector devices are fabricated with excellent electrical contact. The optimized transferred devices show broad range photoresponse with signal‐to‐noise ratios up to 105 and responsivities reaching 0.96 mA W−1. Importantly, access to low‐temperature processing enables the fabrication of flexible devices. Based on this platform, a proof‐of‐concept self‐powered flexible heart rate monitor is fabricated. The achievement of transferable Sb2Se3NR layers introduced in this work is expected to be readily applicable to generate new (001) Sb2Se3 device architectures that may otherwise not be achievable via direct deposition, with application in photoelectrochemical water splitting, battery electrodes, and solar cells.

Abstract Cyanobacterial biofilms are ubiquitous and play important roles in diverse environments, yet, understanding of the processes underlying the development of these aggregates is just emerging. Here we report cell specialization in formation of Synechococcus elongatus PCC 7942 biofilms—a hitherto unknown characteristic of cyanobacterial social behavior. We show that only a quarter of the cell population expresses at high levels the four-gene ebfG-operon that is required for biofilm formation. Almost all cells, however, are assembled in the biofilm. Detailed characterization of EbfG4 encoded by this operon revealed cell-surface localization as well as its presence in the biofilm matrix. Moreover, EbfG1-3 were shown to form amyloid structures such as fibrils and are thus likely to contribute to the matrix structure. These data suggest a beneficial ‘division of labor’ during biofilm formation where only some of the cells allocate resources to produce matrix proteins—‘public goods’ that support robust biofilm development by the majority of the cells. In addition, previous studies revealed the operation of a self-suppression mechanism that depends on an extracellular inhibitor, which supresses transcription of the ebfG-operon. Here we revealed inhibitor activity at an early growth stage and its gradual accumulation along the exponential growth phase in correlation with cell density. Data, however, do not support a threshold-like phenomenon known for quorum-sensing in heterotrophs. Together, data presented here demonstrate cell specialization and imply density-dependent regulation thereby providing deep insights into cyanobacterial communal behavior.

Insect population decline has been reported worldwide, including those of pollinators important for ecosystem services. Therefore, conservation actions which rely on available rigorous species distribution data are necessary to protect biodiversity. Niche modeling is an appropriate approach to distribution maps, but when it comes to bumble bees, few studies have been performed in South America. We modeled ecological niches of nine Colombian Bombus species with MAXENT 3.4 software using bioclimatic variables available from WorldClim. This resulted in maps for each species that show the potential distribution area at the present time. Modeled species maps accurately represent potential niches according to the description of bioclimatic conditions in the species’ habitat. We grouped the species into three clusters based on our results, as well as on distributional information from literature on the topic: High Mountain, Mid- Mountain and inter-Andean, and the Amazon and Eastern Plains Basin. Niche modeling depicted bumble bee species’ distribution in Colombia, the results of which can serve as a useful tool for conservation policies in the country.

Approximately a quarter of patients with infective endocarditis (IE) who have surgical indication only receive antibiotic treatment. Their short-term prognosis is dismal. We aimed to describe the characteristics of this group of patients to evaluate the mortality according to the cause of rejection and type of surgical indication and to analyze their prognostic factors of mortality. From 2005 to 2022, 1105 patients with definite left-sided IE were consecutively attended in three tertiary hospitals. Of them, 912 (82.5%) had formal surgical indication according to the most recent European Guidelines available in each period of the study and 303 (33%) only received medical treatment. These were older, had more comorbidities and higher in-hospital (46% vs. 24%; p < 0.001) and one year mortality (57.1% vs. 27.6%; p < 0.001) than operated patients. The main reason for surgical rejection was high surgical risk (57.1%) and the highest mortality when the cause were severe neurological conditions (76%). When the endocarditis team took the decision not to operate (25.5% of the patients), in-hospital (7%) and one-year mortality (17%) were low. In-hospital mortality associated with each surgical indication was 67% in heart failure, 53% in uncontrolled infection and 45% in prevention of embolisms (p < 0.001). Heart failure (OR: 2.26 CI95%: 1.29–3.96; p = 0.005), Staphylococcus aureus (OR: 3.17; CI95%: 1.72–5.86; p < 0.001) and persistent infection (OR: 5.07 CI95%: 2.85–9.03) are the independent risk factors of in-hospital mortality. One third of the patients with left-sided IE and formal surgical indication are rejected for surgery. In-hospital mortality is very high, especially when heart failure is the indication for surgery and when severe neurological conditions the reason for rejection. Short term prognosis of patients rejected by a specialized endocarditis team is favorable.

Organizations’ survival ability is increasingly constrained by their innovation possibilities, that is, by their capacity to create and share knowledge in order to cope with new and more complex challenges. Aiming for the three axes on which new organizational models must be based (economic, technological, and social innovation), this article carries out a systematic review among five databases on the variables related to innovation in organizations. After applying exclusion criteria, 132 papers out of the 1,215 originally found were analyzed. As a result, an integrating theoretical model was proposed from the organizational psychology perspective: the model of knowledge-sharing organizations. The model allows for cultural, psychosocial, and technological aspects and proposes three levels of analysis: 1) innovative culture and governance (that groups together the characteristics of a culture oriented towards innovation, and the organizational policies into which it is translated); 2) leadership, teams, and people (that includes variables that impact people’s innovative capacity, leadership styles, and forms of teamwork); and 3) technological tools for innovation (that focus on how technology can be used, specifically ICT, to enhance the organization’s innovative capacity). Future directions as well as limitations are addressed at the end of the article.

The Gray’s sea fan, Paramuricea grayi (Johnson, 1861), typically inhabits deep littoral and circalittoral habitats of the eastern temperate and tropical Atlantic Ocean. Along the Iberian Peninsula, where P. grayi is a dominant constituent of circalittoral coral gardens, two segregating lineages (yellow and purple morphotypes) were recently identified using single-copy nuclear orthologues. The mitochondrial genomes of 9 P. grayi individuals covering both color morphotypes were assembled from RNA-seq data, using samples collected at three sites in southern (Sagres and Tavira) and western (Cape Espichel) Portugal. The complete circular mitogenome is 18,668 bp in length, has an A + T-rich base composition (62.5%) and contains the 17 genes typically found in Octocorallia: 14 protein-coding genes (atp6, atp8, cob, cox1-3, mt-mutS, nad1-6, and nad4L), the small and large subunit rRNAs (rns and rnl), and one transfer RNA (trnM). The mitogenomes were nearly identical for all specimens, though we identified a noteworthy polymorphism (two SNPs 9 bp apart) in the mt-mutS of one purple individual that is shared with the sister species P. clavata. The mitogenomes of the two species have a pairwise sequence identity of 99.0%, with nad6 and mt-mutS having the highest rates of non-synonymous substitutions.

Abstract The majority of edge detection algorithms only deal with grayscale images, while their use with color images remains an open problem. This paper explores different approaches to aggregate color information of RGB and HSV images for edge extraction purposes through the usage of the Sobel operator and Canny algorithm. This paper makes use of Berkeley’s image data set, and to evaluate the performance of the different aggregations, the F-measure is computed. Higher potential of aggregations with HSV channels than with RGB channels is found. This article also shows that depending on the type of image used, RGB or HSV, some methods are more appropriate than others.

RNA has been implicated in DNA repair. This work shows that the interplay of RNAPII-generated nascent RNA, RNA:DNA hybrids and the resection factor CtIP guide DNA double strand break repair pathway choice towards error-free homologous recombination.

El hecho de que Constant Nieuwenhuys perteneciera a la generación que tuvo que encargarse de la reconstrucción de Europa tras la Segunda Guerra Mundial tuvo una importancia capital en el desarrollo del proyecto de la Nueva Babilonia. La ciudad planteada por Constant es un nuevo modelo urbano que pretende dar una respuesta arquitectónica a las aspiraciones vitales de su generación, rompiendo por completo con la ciudad tal y como se había entendido hasta ese momento. Una nueva ciudad para el homo ludens, el hombre de las teorías de Johan Huizinga, que se vio liberado de la enajenación de la especialización del trabajo para dedicar su vida al arte y al juego.

Background: To evaluate seroma complications, two techniques were carried out in breast reconstruction: conventional latissimus dorsi flap (CLD) and muscle-sparing latissimus dorsi flap (MSLD) after cancer-related mastectomy. Methods: A total of 108 postmastectomy procedures were performed with autologous tissue reconstruction with latissimus dorsi flaps (LDs) between January 2016 and May 2020. The patients were divided into two groups. The first group was reconstruction with the CLD, and the second group was reconstruction with the MSLD. Forty (40) patients in the first group and 68 patients in the second group were analyzed. Seroma formation was evaluated as the primary outcome. Results: The total number of seromas found in the donor area was 27, of which 45% (n = 18) were found with the CLD and 13.24% (n = 9) with the MSLD, with a difference of 31.76% in favor of the MSLD, with an 95% CI of 14–49 (p

Summary: The role of MDC1 in the DNA damage response has been extensively studied; however, its impact on other cellular processes is not well understood. Here, we describe the role of MDC1 in transcription as a regulator of RNA polymerase II (RNAPII). Depletion of MDC1 causes a genome-wide reduction in the abundance of actively engaged RNAPII elongation complexes throughout the gene body of protein-encoding genes under unperturbed conditions. Decreased engaged RNAPII subsequently alters the assembly of the spliceosome complex on chromatin, leading to changes in pre-mRNA splicing. Mechanistically, the S/TQ domain of MDC1 modulates RNAPII-mediated transcription. Upon genotoxic stress, MDC1 promotes the abundance of engaged RNAPII complexes at DNA breaks, thereby stimulating nascent transcription at the damaged sites. Of clinical relevance, cancer cells lacking MDC1 display hypersensitivity to RNAPII inhibitors. Overall, we unveil a role of MDC1 in RNAPII-mediated transcription with potential implications for cancer treatment.

Este artículo presenta un sistema para la creatividad computacional colaborativa artística aplicada a la creación musical, llamado New Electronic Assistant (NEA). NEA es un sistema que puede aprender de estilos musicales en formato simbólico, generar piezas siguiendo los estilos aprendidos y transformar sus resultados a través de la interacción en tiempo real. A lo largo del texto, NEA es introducido y enmarcado dentro de los conceptos de la creatividad colaborativa computacional. Para analizar el desempeño de NEA en entornos reales de co-creación, se realiza un proceso de generación sistemática de piezas musicales, de las que se extraen fragmentos que son usados en un experimento de validación con humanos. Los resultados del experimento sugieren altos niveles de eficiencia en el proceso de co-creación, relacionados con el tiempo de producción de nuevas piezas, la sorpresa expresada por los participantes del experimento y el valor percibido de las piezas generadas por NEA. El experimento concluye con una sección donde se comentan detalles de las piezas percibidas con mayor valor por los participantes del experimento. Al final del texto se hace una reflexión sobre el rol de los sistemas generativos, que requieren interacción humana, en procesos reales de creación colaborativa.

El texto parte de la inquietud por colocar en el centro de la educación el cuidado del otro ser y la responsabilidad ante la vida de la infancia. El propósito del artículo es ofrecer respuestas a la pregunta sobre qué condiciones hacen posible el encuentro entre quienes habitamos la escuela. Desde un enfoque inspirado en la investigación de la experiencia y la fenomenología-hermenéutica, se realizan conversaciones reflexivas con dos maestras y la directora de una escuela ubicada en un contexto de dificultad. A partir de los materiales empíricos registrados junto a las docentes, los textos de investigación realizan una elaboración conceptual que revela algunas claves prácticas para la creación de nuevas dinámicas relacionales que amplían la potencia acogedora de la escuela. Las conclusiones muestran que la desorganización escolar que provoca la diferencia se convierte, a través de un proceso de composición y reinterpretación, en una oportunidad para el encuentro pedagógico.

Esta investigación identifica factores influyentes sobre el bienestar humano en la comunidad San Jacinto de Santay mediante la interpretación de la satisfacción subjetiva con la vida revelada en un estudio de corte transversal. La variable dependiente fue explicada por la edad, las relaciones sociales y el tiempo disponible para actividades de recreación. Se identificaron los servicios de los ecosistemas percibidos como críticos: aire limpio y alimentos silvestres (principalmente pesca artesanal). El análisis de los resultados, mediante una prueba Mann-Whitney y análisis de covarianza y redundancia, destacó un manejo sustentable y la importancia del entendimiento de los aportes del entorno natural.

The octocoral, Paramuricea clavata, is a habitat-forming anthozoan with a key ecological role in rocky benthic and biodiversity-rich communities in the Mediterranean and Eastern Atlantic. Shallow populations of P. clavata in the North-Western Mediterranean are severely affected by warming-induced mass mortality events (MMEs). These MMEs have differentially impacted individuals and populations of P. clavata (i.e., varied levels of tissue necrosis and mortality rates) over thousands of kilometers of coastal areas. The eco-evolutionary processes, including genetic factors, contributing to these differential responses remain to be characterized. Here, we sequenced a P. clavata individual with short and long read technologies, producing 169.98 Gb of Illumina paired-end and 3.55 Gb of Oxford Nanopore Technologies (ONT) reads. We obtained a de novo genome assembly accounting for 607 Mb in 64,145 scaffolds. The contig and scaffold N50s are 19.15 Kb and 23.92 Kb, respectively. Despite of the low contiguity of the assembly, its gene completeness is relatively high, including 75.8% complete and 9.4% fragmented genes out of the 978 metazoan genes contained in the metazoa_odb9 database. A total of 62,652 protein-coding genes have been annotated. This assembly is one of the few octocoral genomes currently available. This is undoubtedly a valuable resource for characterizing the genetic bases of the differential responses to thermal stress and for the identification of thermo-resistant individuals and populations. Overall, having the genome of P. clavata will facilitate studies of various aspects of its evolutionary ecology and elaboration of effective conservation plans such as active restoration to overcome the threats of global change.

The global biodiversity decline might conceal complex local and group-specific trends. Here the authors report a quantitative synthesis of longterm biodiversity trends across Europe, showing how, despite overall increase in biodiversity metric and stability in abundance, trends differ between regions, ecosystem types, and taxa.

Resumen Diversos autores han planteado en los últimos años que el nuevo escenario que genera la comunicación digital provoca que los ciudadanos tengan un papel con mayor protagonismo en el debate público. Sin embargo, al margen de las múltiples oportunidades políticas y comunicativas surgidas de tras la irrupción de las redes sociales digitales, encontramos algunos riesgos y limitaciones relevantes para la comunicación política como la falta de civismo (Incivility). El objetivo de esta investigación es analizar, a través del estudio del caso de “La manada” (de gran repercusión social y política en España) y haciendo uso de técnicas de Big data, la posible polarización de debate público en la red social Twitter y la existencia de este tipo de prácticas negativas, en especial, cuando afectan a las mujeres. Encontramos un escenario de una extrema polarización en el que ambas partes tienden a usar el tema de debate como pretexto para reforzar las posiciones que separan a la izquierda y la derecha en España.

We present the case of a 59-year-old man with acute B19 parvovirus infection who developed a systemic inflammatory reaction similar to adult-onset Still's disease (AOSD). We discuss the clinical challenge due to overlapping symptoms to distinguish between a primary B19 viral infection and the autoimmune disease it can trigger.

On the basis of network analysis, and within the context of modeling imprecision or vague information with fuzzy sets, we propose an innovative way to analyze, aggregate and apply this uncertain knowledge into community detection of real-life problems. This work is set on the existence of one (or multiple) soft information sources, independent of the network considered, assuming this extra knowledge is modeled by a vector of fuzzy sets (or a family of vectors). This information may represent, for example, how much some people agree with a specific law, or their position against several politicians. We emphasize the importance of being able to manage the vagueness which usually appears in real life because of the common use of linguistic terms. Then, we propose a constructive method to build fuzzy measures from fuzzy sets. These measures are the basis of a new representation model which combines the information of a network with that of fuzzy sets, specifically when it comes to linguistic terms. We propose a specific application of that model in terms of finding communities in a network with additional soft information. To do so, we propose an efficient algorithm and measure its performance by means of a benchmarking process, obtaining high-quality results.

El presente ensayo explora el saber como producto de una alteración y un efecto en los modos de subjetivación. Bajo la referencia del mito griego de Pandora, se reflexiona sobre el deseo de saber, desde la curiosidad preontológica que se instala como pregunta irresuelta a lo largo de la vida. Del mismo modo, con el mito de Psique se aborda la necesidad del despojo de prerrogativas en lo educativo. Se hace énfasis en el saber pedagógico inacabado. El lenguaje, la conversación, el estudio son pretextos que ponen en marcha la búsqueda –la libertad de significación– de la existencia en un tiempo propio. La relación con el saber requiere de un reconocimiento, por encima de los contenidos y guías de aprendizaje, por lo que surge la necesidad de que los docentes acojan unos saberes y se desprendan de otros. De ahí que los saberes provenientes del mundo interno de los educadores puedan estar capturados por la predicción, que se traduce en apatía y desinterés en los estudiantes. Para que el profesor esté disponible para éstos y pueda desencadenar y sostener la función del saber se precisa la generosidad en el ofrecimiento de recursos culturales y la omisión de la lógica de la representación. Elementos que propician que el docente promueva la emancipación de sus estudiantes desde la afirmación de sus capacidades y potencias, desde la confianza y con el consentimiento del otro.

La hernia diafragmática traumática es poco frecuente en la clínica y representa un reto diagnóstico, ya que su aparición es principalmente de emergencia y esto propicia poco tiempo para la realización de estudios de imagen complementarios. Presentamos el caso de un varón de 21 años que sufrió una herida penetrante en el hemitórax izquierdo con sospecha de herniación traumática diafragmática de vísceras abdominales al tórax por radiografía, y en el quirófano se confirmó una herniación esplénica con hemorragia intratorácica. Se propone un algoritmo de manejo en estos casos tan desafiantes.

Aim of the study: Laparoscopic adhesiolysis in small bowel obstruction (SBO) is getting increasingly normal. In patients with multiple adhesive SBOs (MASBO), laparoscopic approaches might increase the risk of bowel injury due to the distended and potentially compromised small bowel. It remains a challenge to the surgeons, entails an interdisciplinary team, trying to achieve the least complications as possible. The study aimed to compare surgical outcomes of laparoscopic procedures (multi-port vs. single-port) in the management of MASBO. Patients and Methods: Comparative study of 68 patients with post-operative MASBO treated with Single-Port single incision laparoscopic surgery (SILS) and Multi-port Laparoscopic Surgery in two centers of Bogota, Colombia between January 2013 and June 2018. Results: All patients underwent laparoscopic management, 27 patients by SILS, and 41 patients by multi-port. The average surgical time in the multiport approach was 167 min versus SILS with 129 min. Laparoscopic intestinal resection was performed in 4.4% of patients, through multi-port using intracorporeal anastomosis. Mean hospital stay of 3.2 days for the SILS approach versus multi-port in 2.2 days. Conclusions: Both laparoscopic approaches, in MASBO treatment is feasible in qualified hands. Patient selection and medical judgment seem to be the most essential factors for a positive result.

Objective: Impingement syndromes are recognized as an important cause of chronic ankle pain, which results from the entrapment of an inflamed soft-tissue component between the osteophytes. The predominant site of occurrence is the anterolateral aspect of the ankle for soft-tissue impingement, and anteromedial aspect for bony impingement. Symptoms related to the physical impact of bone or soft-tissue pain often result in limited ankle range of motion. Methods: We conducted a retrospective study of 34 patients (34 ankles) with anteromedial bony impingement. All patients underwent arthroscopy, with a mean follow-up of 34 months. Results: All osteophytes were removed, and the ankle range of motion improved. The AOFAS score improved from 73 preoperatively to 95 postoperatively. Conclusion: The arthroscopic removal of the anteromedial osteophytes of the ankle had excellent functional results. It is an effective procedure that allows rapid patient recovery. Level of Evidence IV; Therapeutic Studies; Case Series.

Modelling in anaerobic digestion will play a crucial role as a tool for smart monitoring and supervision of the process performance and stability. By far, the Anaerobic Digestion Model No. 1 (ADM1) has been the most recognized and exploited model to represent this process. This study aims to propose simple extensions for the ADM1 model to tackle some overlooked operational and metabolic aspects. Extensions for the discontinuous feeding process, the reduction of the active working volume, the transport of the soluble compound from the bulk to the cell interior, and biomass acclimation are presented in this study. The model extensions are included by a change in the mass balance of the process in batch and continuous operation, the incorporation of a transfer equation governed by the gradient between the extra- and intra- cellular concentration, and a saturation-type function where the time has an explicit influence on the kinetic parameters, respectively. By adding minimal complexity to the existing ADM1, the incorporation of these phenomena may help to understand some underlying process issues that remain unexplained by the current model structure, broadening the scope of the model for control and monitoring industrial applications.

In this paper we introduce the concept of multiple bipolar fuzzy measures as a generalization of a bipolar fuzzy measure. We also propose a new definition of a group, which is based on the multidimensional bipolar fuzzy relations of its elements. Taking into account this information, we provide a novel procedure (based on the well-known Louvain algorithm) to deal with community detection problems. This new method considers the multidimensional bipolar information provided by multiple bipolar fuzzy measures, as well as the information provided by a graph. We also give some detailed computational tests, obtained from the application of this algorithm in several benchmark models.

El presente trabajo está asociado a la colaboración de los autores en dos proyectos de investigación vinculados a la observación de la práctica docente. El enfoque del estudio es la investigación de la experiencia y la pregunta fundamental circunda las posibilidades de organización del aula en medio de situaciones conflictivas. A través de conversaciones hermenéuticas con profesores y la directora de un centro educativo se hallan como categorías de estudio: caos, desorden y afuera o exterioridad, que representan los desplazamientos del oficio docente. Los resultados reflejan una práctica afirmativa fruto de una situación límite que se presenta ante las dificultades para la aplicación de esquemas escolares y pedagógicos preconcebidos.

Introducción. La hernioplastia con malla de polipropileno es la técnica de elección para el reparo de las hernias inguinales. Actualmente, existe controversia sobre esta técnica en pacientes con heridas sucias o contaminadas; sin embargo, la evidencia en la literatura médica ha demostrado que su uso puede ser seguro. Los autores presentan su experiencia con las mallas de polipropileno en la cirugía contaminada para cierre de hernias inguinales. Método. Se realizó un estudio observacional retrospectivo en el que se incluyeron los pacientes mayores de 18 años atendidos entre enero de 2017 y diciembre de 2018 por presentar hernias inguinales, que requirieron tratamiento quirúrgico de urgencias, y que presentaban heridas sucias o contaminadas. Los criterios evaluados fueron: infección de la herida quirúrgica, morbilidad y mortalidad, necesidad de remoción de la malla y recurrencia de la hernia. Resultados. Diez pacientes fueron sometidos a cirugía de urgencias, requiriendo resección intestinal por necrosis: nueve de ellos, por hernias estranguladas y, uno, por apendicitis perforada. En uno de los diez pacientes, se consideró sucia la herida por presentar necrosis intestinal y perforación. Los nueve restantes presentaban necrosis intestinal sin perforación, por lo cual se consideraron heridas contaminadas. La infección de la herida ocurrió en 1/10 pacientes con infección del sitio operatorio superficial; la eliminación de la malla no fue necesaria en ningún paciente durante todo el período de estudio. No se observaron recidivas y no hubo mortalidad. Conclusión. El uso de malla de polipropileno para la corrección de hernias inguinales, en pacientes con heridas sucias o contaminadas, es efectivo y seguro, con una morbilidad aceptable y buenos resultados a corto plazo.

Antecedentes: La lesión del conducto biliar es una complicación devastadora tras una colecistectomía. El tratamiento laparoscópico se ha convertido en un enfoque principal debido a las ventajas ofrecidas a los pacientes; sin embargo, los resultados espués de la reparación están influenciados por el centro, la experiencia del cirujano y el tipo de reconstrucción. Método: Se revisaron retrospectivamente los pacientes con lesión del conducto biliar tratados con reconstrucción biliar en un centro de referencia, desde enero de 2013 hasta junio de 2018, por vía laparoscópica con una técnica modificada y simplificada con hepatoyeyunostomía en Y de Roux. Resultados: Veinte pacientes de 5,430 tenían lesión del conducto biliar (0,3%), 8 (40%) tuvieron diagnóstico intraoperatorio y 12 (60%) diagnóstico antes de las 72 horas. Todos con una clasificación de Strasberg tipo E, con predominio de E1 (65%). El tiempo quirúrgico promedio fue de 146,5 (rango 115-178) minutos y el sangrado intraoperatorio promedio fue de 15-50 cm3. La tasa general de complicaciones fue del 10% (2/20); 1 (5%) paciente requirió reintervención. No hubo mortalidad y la estancia hospitalaria media fue de 5 días. Un paciente (5%) presentó fuga biliar (tipo SE4) y 1 (5%) paciente requirió ingreso en la unidad de cuidados intensivos después de la reintervención. El seguimiento fue de hasta 5 años tras el procedimiento, con un mínimo de 1 año, y no se han documentado estenosis del conducto biliar, colangitis ni coledocolitiasis recurrente. Conclusión: Este enfoque laparoscópico simplificado para la reconstrucción del conducto biliar con anastomosis en Y de Roux parece ser una opción efectiva y segura a la cirugía reconstructiva del conducto biliar abierta, ofreciendo a los pacientes los beneficios de la cirugía laparoscópica y con una baja tasa de complicaciones.

Adult diffuse glioma, particularly glioblastoma (GBM), is a devastating tumor of the central nervous system. The existential threat of this disease requires on-going treatment to counteract tumor progression. The present outcome is discouraging as most patients will succumb to this disease. The low cure rate is consistent with the failure of first-line therapy, radiation and temozolomide (TMZ). Even with their therapeutic mechanism of action to incur lethal DNA lesions, tumor growth remains undeterred. Delivering additional treatments only delays the inescapable development of therapeutic tolerance and disease recurrence. The urgency of establishing lifelong tumor control needs to be re-examined with a greater focus on eliminating resistance. Early genomic and transcriptome studies suggest each tumor subtype possesses a unique molecular network to safeguard genome integrity. Subsequent seminal work on post-therapy tumor progression sheds light on the involvement of DNA repair as the causative contributor for hypermutation and therapeutic failure. In this review, we will provide an overview of known molecular factors that influence the engagement of different DNA repair pathways, including targetable vulnerabilities, which can be exploited for clinical benefit with the use of specific inhibitors.

Abstract Oak regeneration and the expansion of forested sites in Eurasia rely on acorn dispersal by animals, especially the Eurasian jay (Garrulus glandarius). However, in open agroforestry systems where jays are absent, such as old fields far from acorn sources, oak recruitment still occurs. We hypothesize that the Eurasian magpie (Pica pica), an abundant corvid in this system, substitutes the jay in its seed dispersal function. By ringing 169 magpies, video recording >7500 acorn removal events with trail cameras, and radio‐tagging 337 acorns, we quantified that (1) magpies cached 41–56% of the annual acorn production of Quercus ilex trees in single caches on the ground; (2) breeding pairs, and especially males, were the main acorn dispersers; (3) each breeding magpie cached 169–1372 acorns in 6 weeks; and (4) the effectiveness of dispersal (percentage of cached acorns resulting in seedlings) was 0.6–2.4%, which (5) yielded a high density of emerged seedlings (56–439 seedlings/ha). We evidence that magpie could be a key species in the regeneration of oak agroforestry mosaics because they massively and effectively dispersed acorns. However, in our particular study site, effectiveness was low probably due to herbivory and summer drought stress (i.e., a context limitation rather than an intrinsic limitation of the disperser). As the distributions of magpies and oaks overlap widely in Eurasia, effective acorn dispersal by magpies could have a significant role in large‐scale oak forest recovery in strongly fragmented landscapes.

Resumen Se tiende a considerar el McCormick Tribune Campus Center bajo una filiación pop. Sin descartar la evidencia del influjo de Robet Venturi, el artículo argumenta la raigambre surrealista, velada por su colorista y desenfadada retórica. Esta hipótesis no sería incoherente con el aprecio de Rem Koolhaas por las técnicas surrealistas (patentes en Delirious New York) y la apreciación de rasgos surrealistas en su obra temprana por parte de terceros. Se analizan, sobre aspectos concretos del edificio terminado y sobre documentos de desarrollo del proyecto, mecanismos destinados a producir efectos similares a los que los surrealistas perseguían con sus prácticas: la intensificación de la realidad más allá de la pura racionalidad. También sería coherente con el aliento de crítica epistémica que recibe el proyecto de las bases del concurso que le dio lugar, y que motivó la respuesta de Koolhaas mediante el binomio que forman el edificio y su panfleto coetáneo, Junkspace. Abstract Under its casual and colorful appearance, the McCormick Tribune Campus Center built in 2003 at the Chicago IIT campus by Rem Koolhaas constitutes a perplexing -hard to grasp conceptually- architectural piece. The commission origin was an international competition whose bases demanded a building “equal in stature to Mies van der Rohe’s S. R. Crown Hall” that “will express the architecture of our time”. According to Koolhaas, the building, in which he subverts all kind of disciplinary categories that shape Mies’s work, is a built response to the condition of our time described in Junkspace, a text written in parallel to its construction proccess. The article argues that a surreal halo shines under its pop aesthetic. Being its significance reinforced by Koolhaas’ clear appreciation of the findings of the Surrealists -among whom, especially, Dalí’s paranoid-critical method-, it may constitute a clue of deeper arguments that, steeping the strategy and methodology of the project, contribute to articulate the construct with which its author gives response to the competition intellectual demands.

The use of information and telecommunication technologies (ICT) for the development of educational tools such as virtual laboratories has become a valuable teaching support practice in different areas of professional training. Current applications range from virtualization practices in fundamental sciences, to virtual experimentation on specific engineering topics. This paper describes the development of the Virtual Earthquake Engineering Lab (SISMILAB). This lab includes different applications with the objective of becoming an aid in the process of understanding and applying fundamental concepts related to the field of earthquake engineering. The aim of the lab is to strengthen the academic and research experiences of students both inside and outside the classroom. Students have readily used SISMILAB and given positive feedback regarding its effectiveness in conveying concepts and aiding in the visualization and interpretation of results. Finally, the paper discusses the impact of the virtual laboratory based on metrics obtained from questionnaires regarding student and faculty satisfaction.

In this paper we formally define the hierarchical clustering network problem (HCNP) as the problem to find a good hierarchical partition of a network. This new problem focuses on the dynamic process of the clustering rather than on the final picture of the clustering process. To address it, we introduce a new hierarchical clustering algorithm in networks, based on a new shortest path betweenness measure. To calculate it, the communication between each pair of nodes is weighed by the importance of the nodes that establish this communication. The weights or importance associated to each pair of nodes are calculated as the Shapley value of a game, named as the linear modularity game. This new measure, (the node-game shortest path betweenness measure), is used to obtain a hierarchical partition of the network by eliminating the link with the highest value. To evaluate the performance of our algorithm, we introduce several criteria that allow us to compare different dendrograms of a network from two point of view: modularity and homogeneity. Finally, we propose a faster algorithm based on a simplification of the node-game shortest path betweenness measure, whose order is quadratic on sparse networks. This fast version is competitive from a computational point of view with other hierarchical fast algorithms, and, in general, it provides better results.

In an increasingly globalized market, the relationship between the customer and the brand goes beyond the purchasing process. It is very important to understand the customer, to know their needs and to propose actions to increase the value of the brand for them. In the literature, there are several models capable of determining and segmenting customers according to variables dependent on the purchasing process. However, we have not found any study that applies to the business case of classifying customers according to their relationship with the contact centre. In this paper, we establish a working model that allows us to define the value of the customer in the process of interaction with the contact centre, so that we can propose actions both in the sales phase and during the post-sales service, so that the value and perception of the brand is increased. In this model, we propose using the value of recency, frequency, importance and duration of customer interactions with the post-sales service, thus obtaining a ranking, and grouping of customers to help establish personalized communication strategies. We have verified this model by presenting a business case applied to the telecom sector.

As evidenced in parasitism, host and niche shifts are a source of genomic and phenotypic diversification. Exemplary is a reduction in the core metabolism as parasites adapt to a particular host, while the accessory genome often maintains a high degree of diversification. However, selective pressures acting on the genome of organisms that have undergone recent lifestyle or host changes have not been fully investigated. Here, we developed a comparative genomics approach to study underlying adaptive trends in oomycetes, a eukaryotic phylum with a wide and diverse range of economically important plant and animal parasitic lifestyles. Our analysis reveals converging evolution on biological processes for oomycetes that have similar lifestyles. Moreover, we find that certain functions, in particular carbohydrate metabolism, transport, and signaling, are important for host and environmental adaptation in oomycetes. Given the high correlation between lifestyle and genome properties in our oomycete dataset, together with the known convergent evolution of fungal and oomycete genomes, we developed a model that predicts plant pathogenic lifestyles with high accuracy based on functional annotations. These insights into how selective pressures correlate with lifestyle may be crucial to better understand host/lifestyle shifts and their impact on the genome.

The Southern Pacific Coast of Costa Rica shows some local variations in its four Morpho species. The goal of this article is to compare the life cycle of M. amathonte from different areas in Costa Rica and South America. The immature stages were found on Pterocarpus officinalis Jacq. and then photographed and described so as to illustrate its morphology and behavior. It is clear, that M. amathonte from the South Pacific side of Costa Rica comes from one isolated population and demonstrates a cryptic nature between the two forms present in Costa Rica.

Acquired genomic instability is one of the major concerns for the clinical use of induced pluripotent stem cells (iPSCs). All reprogramming methods are accompanied by the induction of DNA damage, of which double-strand breaks are the most cytotoxic and mutagenic. Consequently, DNA repair genes seem to be relevant for accurate reprogramming to minimize the impact of such DNA damage. Here, we reveal that reprogramming is associated with high levels of DNA end resection, a critical step in homologous recombination. Moreover, the resection factor CtIP is essential for cell reprogramming and establishment of iPSCs, probably to repair reprogramming-induced DNA damage. Our data reveal a new role for DNA end resection in maintaining genomic stability during cell reprogramming, allowing DNA repair fidelity to be retained in both human and mouse iPSCs. Moreover, we demonstrate that reprogramming in a resection-defective environment has long-term consequences on stem cell self-renewal and differentiation.

La guerra sin duda constituye uno de los signos del ‘final de los tiempos’ en la Antigüedad. Del análisis de tres casos de estudio, centrados en el Levante de la Edad del Hierro, la Grecia clásica y la Roma bajorrepublicana, parece desprenderse que en ocasiones en la fase posterior a la guerra se fraguaban las condiciones del siguiente conflicto bélico. El ‘final de los tiempos’ significa, desde esta perspectiva, un estadio de conflicto permanente, del que naturalmente la religión tampoco estaba desligado y, en ocasiones, incluso implicaba una razón más para iniciar un nuevo conflicto. En este artículo, por tanto, se analiza la particular relación simbiótica entre ‘guerra’, ‘paz’ y ‘política’ pero también ‘religión’ en los períodos de ‘posconflicto’.

Introducción. La colecistectomía es uno de los procedimientos más comunes en cirugía general y que produjo la explosión de la laparoscopia a finales de los años 80. Una de las complicaciones más temida es la lesión de la vía biliar, en especial en la colecistitis complicada, por lo que la Society of American Gastrointestinal and Endoscopic Surgeons (SAGES) promueve la estrategia de colecistectomía segura. Se presenta una serie de casos que muestra la frecuencia de las lesiones de la vía biliar en las colecistectomías complicadas (grados II y III de la clasificación de Tokio). Materiales y métodos. Se configuró una serie de casos con pacientes a quienes un cirujano general experto en laparoscopia les practicó colecistectomía laparoscópica en el Hospital Universitario Fundación Santa Fe de Bogotá en un periodo de dos años, de enero de 2016 a marzo de 2018. El objetivo era establecer la frecuencia de lesiones de la vía biliar durante la colecistectomía. Resultados. Se identificaron 56 pacientes con colecistitis complicada, 2 (3,57 %) de ellas, Tokio III. Se encontró una frecuencia de complicaciones de 1,78 %, sin evidenciar lesión de la vía biliar. Discusión. La incidencia de lesión de la vía biliar en nuestra población no es superior a la informada, entre 0,2 y 0,4 %, sin necesidad de una colecistectomía subtotal por laparoscopia en la gran mayoría de ellas. En el futuro, debe considerarse el desarrollo de criterios para establecer cuándo se requiere un procedimiento quirúrgico abreviado.

The vicuña (Vicugna vicugna) is the most representative wild ungulate of the high Andes of South America with two recognized morphological subspecies, V. v. mensalis in the north and V. v. vicugna in the south of its distribution. Current vicuña population size (460,000–520,000 animals) is the result of population recovery programs established in response to 500 years of overexploitation. Despite the vicuña’s ecosystemic, economic and social importance, studies about their genetic variation and history are limited and geographically restricted. Here, we present a comprehensive assessment of the genetic diversity of vicuña based on samples collected throughout its distribution range corresponding to eleven localities in Peru and five in Chile representing V. v. mensalis, plus four localities each in Argentina and Chile representing V. v. vicugna. Analysis of mitochondrial DNA and microsatellite markers show contrasting results regarding differentiation between the two vicuña types with mitochondrial haplotypes supporting subspecies differentiation, albeit with only a few mutational steps separating the two subspecies. In contrast, microsatellite markers show that vicuña genetic variation is best explained as an isolation by distance pattern where populations on opposite ends of the distribution present different allelic compositions, but the intermediate populations present a variety of alleles shared by both extreme forms. Demographic characterization of the species evidenced a simultaneous and strong reduction in the effective population size in all localities supporting the existence of a unique, large ancestral population (effective size ∼50,000 individuals) as recently as the mid-Holocene. Furthermore, the genetic variation observed across all localities is better explained by a model of gene flow interconnecting them rather than only by genetic drift. Consequently, we propose space “continuous” Management Units for vicuña as populations exhibit differentiation by distance and spatial autocorrelation linked to sex biased dispersal instead of population fragmentation or geographical barriers across the distribution.

Recently it has been shown that building networks from time series allows to study complex systems to characterize them when they go through a phase transition. This give us the opportunity to study this systems from a entire new point of view. In the present work we have used the natural and horizontal visualization algorithms to built networks of two popular models, which present phase transitions: the Ising model and the Kuramoto model. By measuring some topological quantities as the average degree, or the clustering coefficient, it was found that the networks retain the capability of detecting the phase transition of the system. From our results it is possible to establish that both visibility algorithms are capable of detecting the critical control parameter, as in every quantity analyzed (the average degree, the average path and the clustering coefficient) there is a minimum or a maximum value. In the case of the natural visualization algorithm, the average path results are much more noisy than in the other quantities in the study. Specially for the Kuramoto Model, which in this case does not allow a detection of the critical point at plain sight as for the other quantities. The horizontal visualization algorithm has proven to be more explicit in every quantity, as every one of them show a clear change of behavior before and after the critical point of the transition.