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4 results on '"Daniel J Kearns"'

1. The STREAM Trial (Prostatic Artery Embolization for the Treatment of Benign Prostatic Hyperplasia) 24-Month Clinical and Radiological Outcomes

Author

Daniel J Kearns, Mark Little, Phil Boardman, Tina Mackinnon, Jeremy Crew, Ruth MacPherson, Charles R Tapping, and Andrew Macdonald

Subjects
Male, medicine.medical_specialty, animal structures, Prostatic Hyperplasia, Urology, urologic and male genital diseases, 030218 nuclear medicine & medical imaging, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Quality of life, Refractory, Prostate, Humans, Medicine, Radiology, Nuclear Medicine and imaging, Prospective Studies, Prospective cohort study, Aged, Aged, 80 and over, business.industry, Ultrasound, Arteries, Middle Aged, Hyperplasia, medicine.disease, Embolization, Therapeutic, Magnetic Resonance Imaging, Prostatic artery embolization, Treatment Outcome, medicine.anatomical_structure, Radiological weapon, Quality of Life, Cardiology and Cardiovascular Medicine, business
Abstract

To establish factors predictive of success prior to Prostate Artery Embolization (PAE) with MRI imaging. A prospective cohort study of 50 patients with Benign Prostatic Hyperplasia (BPH) were treated with PAE in a single institution. Patients had moderate to severe symptoms of BPH refractory to medical management for at least 6 months. Patients were imaged with multiparametric MRI imaging pre-PAE and at 3 months, 12 months and 24 months post-PAE. Clinical success was measured with IPSS, IIEF and EQ-5D-5L quality of life questionnaires. The technical success was 48/50 (96%).The mean age of the group was 67 (range 54–83). The mean IPSS score pre-PAE was 21 and at 24 months was 8 (p

Published
2020

2. Patterns of Reperfusion and Clinical Findings in Repeat Prostate Artery Embolisation for Recurrent Lower Urinary Tract Symptoms in Patients with Benign Prostatic Hyperplasia

Author

Daniel J Kearns, Charles R Tapping, and Philip Boardman

Subjects
medicine.medical_specialty, medicine.diagnostic_test, business.industry, Ultrasound, Urology, Hyperplasia, medicine.disease, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, medicine.anatomical_structure, Prostate, Lower urinary tract symptoms, Angiography, medicine, Radiology, Nuclear Medicine and imaging, In patient, International Prostate Symptom Score, Cardiology and Cardiovascular Medicine, business, Artery
Abstract

To present our experience of the patterns of revascularisation of the prostate and efficacy of repeat prostate artery embolisation (rPAE) in patients with recurrence of lower urinary tract symptoms. We retrospectively analysed 12 patients who underwent rPAE at a single centre between November 2015 and March 2020. The patients had their intraprocedural angiography and cone beam CT images as well as their pre-procedural CT retrospectively reviewed to establish the patterns of revascularisation. Clinical follow-up occurred at a minimum of 3 months. 11/12 patients (91.6%) had significant international prostate symptom score (IPSS) reduction following rPAE with change in mean IPSS from 18.4 to 8.1 at 3 months (p

Published
2020

3. Delayed Post COVID-19 Bronchial Artery Pseudoaneurysm Treated with Embolisation: Letter to the Editor

Author

Simon A. Braithwaite, Eric Douglas, Daniel J. Kearns, Rachel K. Hoyles, and Charles R. Tapping

Subjects
medicine.medical_specialty, 2019-20 coronavirus outbreak, Letter to the editor, Coronavirus disease 2019 (COVID-19), business.industry, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), medicine.disease, Pseudoaneurysm, medicine.artery, medicine, Radiology, Nuclear Medicine and imaging, Radiology, Cardiology and Cardiovascular Medicine, business, Bronchial artery, Letter to the Editor
Published
2021

4. Patterns of Reperfusion and Clinical Findings in Repeat Prostate Artery Embolisation for Recurrent Lower Urinary Tract Symptoms in Patients with Benign Prostatic Hyperplasia

Author

Daniel J, Kearns, Philip, Boardman, and Charles R, Tapping

Subjects
Male, Time Factors, Angiography, Prostatic Hyperplasia, Arteries, Cone-Beam Computed Tomography, Middle Aged, Embolization, Therapeutic, Treatment Outcome, Lower Urinary Tract Symptoms, Recurrence, Humans, Aged, Retrospective Studies
Abstract

To present our experience of the patterns of revascularisation of the prostate and efficacy of repeat prostate artery embolisation (rPAE) in patients with recurrence of lower urinary tract symptoms.We retrospectively analysed 12 patients who underwent rPAE at a single centre between November 2015 and March 2020. The patients had their intraprocedural angiography and cone beam CT images as well as their pre-procedural CT retrospectively reviewed to establish the patterns of revascularisation. Clinical follow-up occurred at a minimum of 3 months.11/12 patients (91.6%) had significant international prostate symptom score (IPSS) reduction following rPAE with change in mean IPSS from 18.4 to 8.1 at 3 months (p 0.0001). Mean prostate volume was reduced by 41.6% (p = 0.03). 8/12 (75%) had a complete clinical success. 20/24 hemiprostates demonstrated revascularisation angiographically, of which 16 (80%) had prostatic arterial supply at rPAE by the main prostatic artery. Other mechanisms of revascularisation included supply from capsular prostatic artery branches and supply from other internal iliac pelvic branches. Unilateral embolisation at rPAE, where bilateral embolisation was not feasible (4/12), resulted in no difference in clinical outcomes compared with bilateral rPAE (p = 0.55).We have found rPAE to be an effective treatment for recurrent lower urinary tract symptoms in patients who had good clinical response to initial PAE. The mechanisms of revascularisation are variable, but most patients that underwent rPAE had recanalisation of their main prostatic artery.

Published
2020

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