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134 results on '"Danilova, Nadia"'

2. Innate immune system activation in zebrafish and cellular models of Diamond Blackfan Anemia.

Author

Danilova, Nadia, Wilkes, Mark, Bibikova, Elena, Youn, Min-Young, Sakamoto, Kathleen M, and Lin, Shuo

Subjects
K562 Cells, Animals, Zebrafish, Humans, Anemia, Diamond-Blackfan, Disease Models, Animal, Benzamides, Benzhydryl Compounds, Dioxoles, Activins, Activin Receptors, Transforming Growth Factor beta, Arginine, Zebrafish Proteins, Interferons, Ribosomal Proteins, RNA, Small Interfering, Up-Regulation, Complement C3a, Tumor Suppressor Protein p53, Toll-Like Receptor 3, Immunity, Innate, Receptor, Transforming Growth Factor-beta Type I, Anemia, Diamond-Blackfan, Disease Models, Animal, Immunity, Innate, RNA, Small Interfering, Receptor, Transforming Growth Factor-beta Type I
Abstract

Deficiency of ribosomal proteins (RPs) leads to Diamond Blackfan Anemia (DBA) associated with anemia, congenital defects, and cancer. While p53 activation is responsible for many features of DBA, the role of immune system is less defined. The Innate immune system can be activated by endogenous nucleic acids from non-processed pre-rRNAs, DNA damage, and apoptosis that occurs in DBA. Recognition by toll like receptors (TLRs) and Mda5-like sensors induces interferons (IFNs) and inflammation. Dying cells can also activate complement system. Therefore we analyzed the status of these pathways in RP-deficient zebrafish and found upregulation of interferon, inflammatory cytokines and mediators, and complement. We also found upregulation of receptors signaling to IFNs including Mda5, Tlr3, and Tlr9. TGFb family member activin was also upregulated in RP-deficient zebrafish and in RPS19-deficient human cells, which include a lymphoid cell line from a DBA patient, and fetal liver cells and K562 cells transduced with RPS19 shRNA. Treatment of RP-deficient zebrafish with a TLR3 inhibitor decreased IFNs activation, acute phase response, and apoptosis and improved their hematopoiesis and morphology. Inhibitors of complement and activin also had beneficial effects. Our studies suggest that innate immune system contributes to the phenotype of RPS19-deficient zebrafish and human cells.

Published
2018

17. 7.345 Evolution of the Immune System, Spring 2005

Author

Danilova, Nadia and Danilova, Nadia

Abstract

In this course, evolutionary pathways that have led to the development of innate and adaptive immunity are analyzed, the conserved and unique features of the immune response from bacteria to higher vertebrates is traced, and factors, such as adaptive changes in pathogens that have shaped the evolution of immune system are identified.This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting.

Published
2023

27. Contributors

Author

Alt, Frederick W., primary, Birshtein, Barbara, additional, Bona, Constantin A., additional, Bonilla, Francisco, additional, Brandtzaeg, Per, additional, Bruggemann, Marianne, additional, Burrows, Peter, additional, Calame, Kathryn, additional, Carroll, Michael C., additional, Cogné, Michel, additional, Cooper, Max D., additional, Cyster, Jason, additional, Danilova, Nadia, additional, Davis, Randall S., additional, Fearon, Douglas T., additional, Ferrando, Adolfo, additional, Flajnik, Martin F., additional, Geha, Raif S., additional, Hardie, Deborah L, additional, Hendershot, Linda, additional, Honjo, Tasuku, additional, Hsu, Ellen, additional, Kearney, John F., additional, Kincade, Paul W., additional, Kinoshita, Kazuo, additional, Knight, Katherine L., additional, Krangel, Michael, additional, Lamm, Michael E., additional, Lanning, Dennis, additional, LeBien, Tucker W., additional, Lefranc, Gerard, additional, Lefranc, Marie-Paul, additional, Lewis, Susanna, additional, Litman, Gary W., additional, Look, A. Thomas, additional, MacLennan, Ian C.M., additional, Maizels, Nancy, additional, Mariuzza, Roy, additional, Marks, Jim, additional, Matsuda, Fumihiko, additional, Melchers, Fritz, additional, Morse, Herbert C., additional, Morton, H. Craig, additional, Muramatsu, Masamichi, additional, Nitschke, Lars, additional, Oettinger, Marjorie A., additional, Osborne, Barbara A., additional, Radbruch, Andreas, additional, Rajewsky, Klaus, additional, Ravetch, Jeffrey V., additional, Reth, Michael, additional, Riblet, Roy, additional, Scharff, Matthew, additional, Schlissel, Mark S., additional, Sekiguchi, JoAnn, additional, Sen, Ranjan, additional, Shlomchik, Mark, additional, Sitia, Robero, additional, Stavnezer, Janet M., additional, Steiner, Lisa A., additional, Stevenson, Freda, additional, Sundberg, Eric, additional, Tsurushita, Naoya, additional, Vquez, Maximiliano, additional, von Andrian, Ulrich H., additional, von Andrian, Urich H., additional, Warr, Gregory W., additional, Wienands, Jurgen, additional, Willett, Catherine, additional, Wu, Gillean, additional, Zachau, Hans G., additional, and Zhang, Zhixin, additional

Published
2004
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