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2. Immediate-release/extended-release amantadine (OS320) to treat Parkinson's disease with levodopa-induced dyskinesia: Analysis of the randomized, controlled ALLAY-LID studies

Author

Azulay, Jean-Philippe, Balaguer, Ernest, Bhatia, Perminder, Bodis-Wollner, Ivan, Brownstone, Paul, Boulloche, Nicolas, Calegan, Gerald J., II, Castelnovo, Giovanni, Chou, Kelvin L., Corvol, Jean-Christophe, Danisi, Fabio, Defebvre, Luc, Desojo, Lydia Vela, Durif, Franck, Ehret, Reinhard, Evans, Bradley K., Forchetti, Concetta, Friedman, Joseph H., Fogel, Wolfgang, Garniga, Matilde Calopa, Gil, Ramon A., Ginsberg, Paul L., Glasberg, Mark R., Griffith, Alida, Groves, Jeffrey W., Gudesblatt, Mark, Hermanowicz, Neal, Herrera, Maria A., Houeto, Jean-Luc, Hutchman, Robert M., Isaacson, Stuart H., Jagadeesan, Singar, Jog, Mandar, Keegan, Andrew, Klostermann, Fabian, Krystkowiak, Pierre, Kulisevsky Bojarsky, Jaime, Kumar, Rajeev, Lacey, Dennis, Lasker, Bruce, LaVaccare, John, Lavallee, Michelle M., Piudo, Maria Rosario Luquin, Mahler, Andreas, Domenech, Maria José Martí, Martinez Castrillo, Juan Carlos, Mate, Laszlo J., Mendis, Tilak, Metman, Leonard Verhagen, Muhlack, Siegfried Martin, Müller, Thomas, Park, Ariane, Patton, James, Peckham, Elizabeth, Grandas Pérez, Francisco, Rabin, Marcie, Rascol, Olivier, Reifschneider, Gerd, Remy, Philippe, Rivera, Pablo Mir, Schwarz, Johannes, Roullet-Solignac, Isabelle, Salazar, Gabriel, Sergay, Stephen M., Sherman, Scott, Shubin, Richard, Spikol, Lorraine, Steigerwald, Frank, Tönges, Lars, Truong, Daniel D., Ugarte, Antonio, Vivancos Matellano, Francisco, Witte, Arnold, Zesiewicz, Theresa, Zauber, Sarah Elizabeth, deVries, Tina, Jaros, Mark, Quartel, Adrian, and Jacobs, David

Published
2022
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5. Immediate-release/extended-release amantadine (OS320) to treat Parkinson's disease with levodopa-induced dyskinesia: Analysis of the randomized, controlled ALLAY-LID studies

Author

Rascol, Olivier, primary, Tönges, Lars, additional, deVries, Tina, additional, Jaros, Mark, additional, Quartel, Adrian, additional, Jacobs, David, additional, Azulay, Jean-Philippe, additional, Balaguer, Ernest, additional, Bhatia, Perminder, additional, Bodis-Wollner, Ivan, additional, Brownstone, Paul, additional, Boulloche, Nicolas, additional, Calegan, Gerald J., additional, Castelnovo, Giovanni, additional, Chou, Kelvin L., additional, Corvol, Jean-Christophe, additional, Danisi, Fabio, additional, Defebvre, Luc, additional, Desojo, Lydia Vela, additional, Durif, Franck, additional, Ehret, Reinhard, additional, Evans, Bradley K., additional, Forchetti, Concetta, additional, Friedman, Joseph H., additional, Fogel, Wolfgang, additional, Garniga, Matilde Calopa, additional, Gil, Ramon A., additional, Ginsberg, Paul L., additional, Glasberg, Mark R., additional, Griffith, Alida, additional, Groves, Jeffrey W., additional, Gudesblatt, Mark, additional, Hermanowicz, Neal, additional, Herrera, Maria A., additional, Houeto, Jean-Luc, additional, Hutchman, Robert M., additional, Isaacson, Stuart H., additional, Jagadeesan, Singar, additional, Jog, Mandar, additional, Keegan, Andrew, additional, Klostermann, Fabian, additional, Krystkowiak, Pierre, additional, Kulisevsky Bojarsky, Jaime, additional, Kumar, Rajeev, additional, Lacey, Dennis, additional, Lasker, Bruce, additional, LaVaccare, John, additional, Lavallee, Michelle M., additional, Piudo, Maria Rosario Luquin, additional, Mahler, Andreas, additional, Domenech, Maria José Martí, additional, Martinez Castrillo, Juan Carlos, additional, Mate, Laszlo J., additional, Mendis, Tilak, additional, Metman, Leonard Verhagen, additional, Muhlack, Siegfried Martin, additional, Müller, Thomas, additional, Park, Ariane, additional, Patton, James, additional, Peckham, Elizabeth, additional, Grandas Pérez, Francisco, additional, Rabin, Marcie, additional, Rascol, Olivier, additional, Reifschneider, Gerd, additional, Remy, Philippe, additional, Rivera, Pablo Mir, additional, Schwarz, Johannes, additional, Roullet-Solignac, Isabelle, additional, Salazar, Gabriel, additional, Sergay, Stephen M., additional, Sherman, Scott, additional, Shubin, Richard, additional, Spikol, Lorraine, additional, Steigerwald, Frank, additional, Truong, Daniel D., additional, Ugarte, Antonio, additional, Vivancos Matellano, Francisco, additional, Witte, Arnold, additional, Zesiewicz, Theresa, additional, and Zauber, Sarah Elizabeth, additional

Published
2022
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8. Clinical Outcome and Characterization of Local Field Potentials in Holmes Tremor Treated with Pallidal Deep Brain Stimulation

Author

Ramirez-Zamora, Adolfo, Kaszuba, Brian C, Gee, Lucy, Prusik, Julia, Danisi, Fabio, Shin, Damian, and Pilitsis, Julie G

Subjects
lcsh:Diseases of the musculoskeletal system, Globus pallidus, Neurophysiology, Case Reports, Holmes Tremor (HT), lcsh:RC346-429, 03 medical and health sciences, 0302 clinical medicine, Tremor, 0502 economics and business, lcsh:Neurology. Diseases of the nervous system, 030304 developmental biology, 0303 health sciences, FOS: Clinical medicine, 05 social sciences, Neurosciences, Deep Brain Stimulation (DBS), Power Spectral Densities (PSD), nervous system diseases, nervous system, Brain stimulation, Local Field Potentials (LFP), Medicine, lcsh:RC925-935, Internal Arterio-Venous Fistula, 050203 business & management, 030217 neurology & neurosurgery
Abstract

Background: Holmes tremor (HT) is an irregular, low-frequency rest tremor associated with prominent action and postural tremors. Currently, the most effective stereotactic target and neurophysiologic characterization of HT, specifically local field potentials (LFPs) are uncertain. We present the outcome, intraoperative neurophysiologic analysis with characterization of LFPs in a patient managed with left globus pallidus interna deep brain stimulation (Gpi DBS). Case Report: A 24-year-old male underwent left Gpi DBS for medically refractory HT. LFPs demonstrated highest powers in the delta range in Gpi. At the 6-month follow-up, a 90% reduction in tremor was observed. Discussion: Pallidal DBS should be considered as an alternative target for management of refractory HT. LFP demonstrated neuronal activity associated with higher power in the delta region, similarly seen in patients with generalized dystonia., Tremor and Other Hyperkinetic Movements, Tremor and Other Hyperkinetic Movements

Published
2016

10. Therapeutic strategies to improve patient function and quality of life

Author

Danisi, Fabio

Subjects
Aging -- Health aspects, Aged -- Health aspects, Geriatrics -- Practice, Quality of life -- Physiological aspects, Parkinson's disease -- Drug therapy, Dopa -- Adverse and side effects, Dopamine -- Agonists, MAO inhibitors -- Physiological aspects, Health, Seniors
Published
2002

12. MR findings in AIDS-associated myelopathy

Author

Chong, June, Rocco, Alessandro Di, Tagliati, Michele, Danisi, Fabio, Simpson, David M., and Atlas, Scott W.

Subjects
Adult, Male, Neurologic Examination, Acquired Immunodeficiency Syndrome, HIV Infections, Middle Aged, Magnetic Resonance Imaging, Spine, Spinal Cord Diseases, Editorial, Spinal Cord, HIV-1, Humans, Female, Atrophy, Retrospective Studies
Abstract

BACKGROUND AND PURPOSE: The most common cause of spinal cord disease among patients with AIDS or those infected with HIV-1 is AIDS-associated myelopathy. The purpose of this study was to determine the MR characteristics of the spinal cord in this patient population and to correlate these findings with the clinical severity of myelopathy. METHODS: MR images of the spinal cord in 21 patients with documented HIV-1 infection or AIDS and a clinical diagnosis of AIDS-associated myelopathy were assessed retrospectively for atrophy, intrinsic signal abnormality, and abnormal enhancement. The clinical severity of myelopathy was graded by a neurologist on the basis of physical examination, and a qualitative correlation was made with the MR findings. RESULTS: MR findings were abnormal in 18 of the 21 patients. The most common feature was spinal cord atrophy (n = 15), typically involving the thoracic cord with or without cervical cord involvement, followed by intrinsic cord signal abnormality (n = 6), and normal-appearing cord (n = 3). Three patients had both cord atrophy and intrinsic cord signal abnormality. The cord signal abnormality was diffuse, without predilection for any specific distribution pattern. Enhancement was not seen in any of the 10 patients who received intravenous contrast material. Only one of 16 patients with moderate to severe myelopathy had normal MR findings, as compared with two of five patients with mild myelopathy. CONCLUSION: MR findings in the spinal cord are abnormal in the majority of patients with AIDS-associated myelopathy, typically showing spinal cord atrophy, with or without intrinsic cord signal abnormality. Patients with moderate to severe myelopathy have an increased frequency of spinal cord abnormalities, but a definite correlation between clinical severity of myelopathy and extent of MR abnormalities remains to be established.

Published
1999

14. XCiDaBLE: An Observational, Prospective Trial Evaluating Xeomin (IncobotulinumtoxinA) for Cervical Dystonia or Blepharospasm in the United States – Interim Results from the First 145 Subjects with Cervical Dystonia (P07.192)

Author

Fernandez, Hubert, primary, Pagan, Fernando, additional, Danisi, Fabio, additional, Greeley, David, additional, Jankovic, Joseph, additional, Verma, Amit, additional, Sethi, Kapil, additional, and Pappert, Eric, additional

Published
2013
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16. Activity enhances dopaminergic long-duration response in Parkinson disease

Author

Jung Kang, Un, primary, Auinger, Peggy, additional, Fahn, Stanley, additional, Oakes, David, additional, Shoulson, Ira, additional, Kieburtz, Karl, additional, Rudolph, Alice, additional, Marek, Kenneth, additional, Seibyl, John, additional, Lang, Anthony, additional, Olanow, C. Warren, additional, Tanner, Caroline, additional, Schifitto, Giovanni, additional, Zhao, Hongwei, additional, Reyes, Lydia, additional, Shinaman, Aileen, additional, Comella, Cynthia L., additional, Goetz, Christopher, additional, Blasucci, Lucia M., additional, Samanta, Johan, additional, Stacy, Mark, additional, Williamson, Kelli, additional, Harrigan, Mary, additional, Greene, Paul, additional, Ford, Blair, additional, Moskowitz, Carol, additional, Truong, Daniel D., additional, Pathak, Mayank, additional, Jankovic, Joseph, additional, Ondo, William, additional, Atassi, Farah, additional, Hunter, Christine, additional, Jacques, Carol, additional, Friedman, Joseph H., additional, Lannon, Margaret, additional, Russell, David S., additional, Jennings, Danna, additional, Fussell, Barbara, additional, Standaert, David, additional, Schwarzschild, Michael A., additional, Growdon, John H., additional, Tennis, Marsha, additional, Gauthier, Serge, additional, Panisset, Michel, additional, Hall, Jean, additional, Gancher, Stephen, additional, Hammerstad, John P., additional, Stone, Claudia, additional, Alexander-Brown, Barbara, additional, Factor, Stewart A., additional, Molho, Eric, additional, Brown, Diane, additional, Evans, Sharon, additional, Clark, Jeffrey, additional, Manyam, Bala, additional, Simpson, Patricia, additional, Wulbrecht, Brian, additional, Whetteckey, Jacqueline, additional, Martin, Wayne, additional, Roberts, Ted, additional, King, Pamela, additional, Hauser, Robert, additional, Zesiewicz, Theresa, additional, Gauger, Lisa, additional, Trugman, Joel, additional, Wooten, G. Frederick, additional, Rost-Ruffner, Elke, additional, Perlmutter, Joel, additional, Racette, Brad A., additional, Suchowersky, Oksana, additional, Ranawaya, Ranjit, additional, Wood, Susan, additional, Pantella, Carol, additional, Kurlan, Roger, additional, Richard, Irene, additional, Pearson, Nancy, additional, Caviness, John N., additional, Adler, Charles, additional, Lind, Marlene, additional, Simuni, Tanya, additional, Siderowf, Andrew, additional, Colcher, Amy, additional, Lloyd, Mary, additional, Weiner, William, additional, Shulman, Lisa, additional, Koller, William, additional, Lyons, Kelly, additional, Feldman, Robert G., additional, Saint-Hilaire, Marie H., additional, Ellias, Samuel, additional, Thomas, Cathi-Ann, additional, Juncos, Jorge, additional, Watts, Ray, additional, Partlow, Anna, additional, Tetrud, James, additional, Togasaki, Daniel M., additional, Stewart, Tracy, additional, Mark, Margery H., additional, Sage, Jacob I., additional, Caputo, Debbie, additional, Gould, Harry, additional, Rao, Jayaraman, additional, McKendrick, Ann, additional, Brin, Mitchell, additional, Danisi, Fabio, additional, Benabou, Reina, additional, Hubble, Jean, additional, Paulson, George W., additional, Reider, Carson, additional, Birnbaum, Alex, additional, Miyasaki, Janis, additional, Johnston, Lisa, additional, So, Julie, additional, Pahwa, Rajesh, additional, Dubinsky, Richard M., additional, Wszolek, Zbigniew, additional, Uitti, Ryan, additional, Turk, Margaret, additional, Tuite, Paul, additional, Rottenberg, David, additional, Hansen, Joy, additional, Ramos, Serrano, additional, Waters, Cheryl, additional, Lew, Mark, additional, Welsh, Mickie, additional, Kawai, Connie, additional, O'Brien, Christopher, additional, Kumar, Rajeev, additional, Seeberger, Lauren, additional, Judd, Deborah, additional, Mendis, Tilak, additional, Barclay, C. Lynn, additional, Grimes, David A., additional, Sutherland, Laura, additional, Dawson, Ted, additional, Reich, Stephen, additional, Dunlop, Rebecca, additional, Albin, Roger, additional, Frey, Kirk, additional, and Wernette, Kristine, additional

Published
2012
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17. ε‐sarcoglycan mutations found in combination with other dystonia gene mutations

Author

Klein, Christine, primary, Liu, Liu, additional, Doheny, Dana, additional, Kock, Norman, additional, Müller, Birgitt, additional, De Carvalho Aguiar, Patricia, additional, Leung, Joanne, additional, De Leon, Deborah, additional, Bressman, Susan B., additional, Silverman, Jeremy, additional, Smith, Christopher, additional, Danisi, Fabio, additional, Morrison, Chris, additional, Walker, Ruth H., additional, Velickovic, Miodrag, additional, Schwinger, Eberhard, additional, Kramer, Patricia L., additional, Breakefield, Xandra O., additional, Brin, Mitchell F., additional, and Ozelius, Laurie J., additional

Published
2002
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19. Parkinson's disease.

Author

Danisi, Fabio, Weinberger, Jesse, and Marin, Deborah B.

Subjects
*PARKINSON'S disease treatment, *DISEASES in older people
Abstract

Provides information on several strategies for pharmacologic management of Parkinson's disease (PD) in the elderly. Background on several pharmacologic agents to manage PD symptoms; Recommended dosage; Side effects.

Published
2002

20. The role of somatosensory evoked potentials in the diagnosis of AIDS-associated myelopathy

Author

Tagliati, Michele, Di Rocco, Alessandro, Danisi, Fabio, and Simpson, David M.

Abstract

Although AIDS-associated vacuolar myelopathy is detected in >50 of autopsy cases, it is often unrecognized during life. The clinical assessment is often difficult because of concurrent peripheral neuropathy and lack of specific diagnostic markers. Somatosensory evoked potentials (SEPs) have been successfully used to evaluate central conduction in a number of diseases involving the spinal cord.

Published
2000

22. Epsilon-sarcoglycan mutations found in combination with other dystonia gene mutations.

Author

Klein C, Liu L, Doheny D, Kock N, Müller B, de Carvalho Aguiar P, Leung J, de Leon D, Bressman SB, Silverman J, Smith C, Danisi F, Morrison C, Walker RH, Velickovic M, Schwinger E, Kramer PL, Breakefield XO, Brin MF, and Ozelius LJ

Subjects
Base Sequence genetics, Carrier Proteins genetics, DNA Mutational Analysis, Humans, Molecular Sequence Data, Pedigree, Receptors, Dopamine D2 genetics, Sarcoglycans, Cytoskeletal Proteins genetics, Dystonia genetics, Membrane Glycoproteins genetics, Molecular Chaperones, Mutation genetics
Abstract

Myoclonus-dystonia is a movement disorder associated with mutations in the epsilon-sarcoglycan gene (SGCE) in most families and in the DRD2 and DYT1 genes in two single families. In both of the latter families, we also found a mutation of SGCE. The molecular mechanisms through which the detected mutations may contribute to myoclonus-dystonia remain to be determined.

Published
2002
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23. Parkinson's disease. Therapeutic strategies to improve patient function and quality of life.

Author

Danisi F

Subjects
Aged, Carbidopa therapeutic use, Catechol O-Methyltransferase Inhibitors, Dopamine Agonists therapeutic use, Drug Combinations, Female, Humans, Levodopa therapeutic use, Male, Middle Aged, Monoamine Oxidase Inhibitors therapeutic use, Quality of Life, Antiparkinson Agents therapeutic use, Parkinson Disease drug therapy
Abstract

Idiopathic Parkinson's disease (PD) is an age-related neuro-degenerative disorder characterized by slowness, stiffness, resting tremor, gait impairment, and postural instability. Levodopa is the most potent pharmacologic agent for symptom management and is associated with an increase in quality of life and longevity for patients with PD, but chronic use causes motor complications. The availability of several newer types of agents--dopamine agonists, monoamine oxidase inhibitors, and catechol-O-methyltransferase inhibitors--gives physicians increased flexibility with regard to first-line therapy, adjunct therapy, and managing or reducing the frequency of motor complications and other side effects associated with chronic levodopa therapy.

Published
2002

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