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918 results on '"Danube-University Krems"'

1. Mental Health Burden and Help-seeking Behavior in the Austrian General Population

Author: Danube University Krems
Published: 2024

2. Mesenteric Infiltration in Ovarian Cancer (MIO)

Author: Danube University Krems, Institut du Cancer de Montpellier - Val d'Aurelle, and Ente Ospedaliero Cantonale, Ticino, Switzerland
Published: 2024

3. Nitrate, Exercise and Vascular Function in Midlife Women (Women's-Beet)

Author: Medical University of Vienna, Danube University Krems, University of Giessen, Edith Cowan University, Flinders University, and Oliver Neubauer, Dr. (PhD) Priv.-Doz.
Published: 2024

4. Anatomic Endoscopic Prostate Enucleation and BICEP Classification (BICEP)

Author: Danube University Krems, University General Hospital of Heraklion, Paracelsus Medical University, University of Turin, Italy, Menoufia University, Acibadem Ankara Hospital, Universitätsmedizin Mannheim, Martini-Klinik am UKE GmbH, Asklepios Kliniken Hamburg GmbH, Istanbul Medipol University Hospital, Saint Petersburg State University, Russia, HM Sanchinarro University Hospital, Alexandria University, Spital Thurgau AG, Medical University of Graz, King's College Hospital NHS Trust, Sheikh Khalifa Medical City, and Selim Soyturk, Research Assistant
Published: 2024

5. Nutrition and Movement to Improve Quality of Life With Knee Osteoarthritis (NUMOQUA)

Author: University of Vienna and Danube University Krems
Published: 2023

6. Motor Learning in Knee Osteoarthritis (MLKOA)

Author: Danube University Krems, Karl Landsteiner University of Health Sciences, Orthopedic Hospital Speising, and Wondrasch, FH-Professor Barbara Wondrasch, PhD
Published: 2020

7. Efficacy of Augmented Feedback on Lumbar Postural and Movement Control During Physiotherapy and Home Exercise

Author: Danube University Krems, MedBase Brunngasse Winterthur, and Markus J. Ernst, research associate
Published: 2019

8. Training Induced Reduction of Lower-limb Joint Loads During Locomotion in Obese Children

Author: University of Vienna, Medical University of Vienna, and Danube University Krems
Published: 2018

9. Towards Digital Anti-Corruption Typology for Public Service Delivery

Author: Fredrick Mutungi, Rehema Baguma, Tomasz Janowski, and Danube University Krems, Austria
Subjects: Typology, medicine.medical_specialty, Corrupt practices, Corruption, business.industry, 050204 development studies, Public health, media_common.quotation_subject, 05 social sciences, Audit, Public relations, Payment, 0506 political science, Public service delivery, 0502 economics and business, 050602 political science & public administration, medicine, Business, Database transaction, media_common
Abstract: Digital anti-corruption refers to a family of digital technology tools that are used to fight corruption. Many such tools have not performed well in practice due to their non-alignment with forms of corruption they are supposed to fight against and persistence of corruption-enabling conditions. The aim of this paper is to contribute to filling this gap by offering a typology of digital anti-corruption in public service delivery that can be used to decide what digital measures should be applied to fight against specific forms of corruption or address specific corruption-enabling conditions. The typology also highlights that digital technology can both assist in corrupt practices e.g. theft of digital personal records, and aid the fight against corruption e.g. mobile channels to report incidents of corruption, automated audits of transaction records to uncover fraudulent payments, or service automation to replace discretionary decision making by public officials with rule-based automated decision-making. The typology is grounded in research and policy literature, validated using real-life examples from East Africa, and instantiated to the public health sector. The paper concludes by presenting a range of scenarios for using the typology and offers some recommendations for public authorities.
Published: 2019
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10. Fourth European stroke science workshop

Author: Paris 5, INSERM U894, Paris, France (JCB), Department of Neurology, Cantonal Hospital Aarau, Aarau, Switzerland (KN), Stroke Trials Unit, University of Nottingham, Nottingham NG5 1PB UK (PMB), Institute of Cardiovascular and Medical Sciences, University of Glasgow, United Kingdom (TJQ), Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, the Netherlands (ER), Department of Neurology and Stroke, and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany (UZ), Institute for Stroke and Dementia Research, Klinikum der Universität München, Munich, Germany (AL, MDü), Munich Cluster for Systems Neurology (SyNergy), Munich, Germany (AL, MDü), Department of Medicine, University of Thessaly, Larissa, Greece (GN), Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA (CI), Institute of Cardiovascular & Medical Sciences, University of Glasgow, Glasgow, United Kingdom (KRL), University of Copenhagen, Bispebjerg Hospital, Department of Neurology, Copenhagen, Denmark (HC), Department of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA (SJvW), Sydney Medical School, University of Sydney, Sydney, Australia (CSA), Pharmaceutics Research Laboratory, School of Life Sciences, University of Sussex, Brighton, UK (CAM), Inserm, Bordeaux Population Health Research Center, UMR 1219, Univ. Bordeaux, ISPED, Bordeaux School of Public. Health, Bordeaux, France (CD), CHU de Bordeaux, Pôle de santé, publique, Bordeaux, France (CD), Center of Functionally Integrative Neuroscience, 53154 Aarhus University, Aarhus, Denmark (LO), Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom (NJS), Department of Neurology, Inselspital, University Hospital Bern, University of Bern, Switzerland (UF, HM), Radboud University Nijmegen Medical Center, Donders Institute Brain Cognition & Behaviour, Center for Neuroscience Department of Neurology, Nijmegen, The Netherlands (FEdL), Department of Neurology, Lund University, Lund, Sweden (BN), Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands (GJB, GJER), Univ. Lille, Inserm, CHU Lille, Degenerative and Vascular Cognitive Disorders, Lille, France (CC), Department of Neurology, Sainte-Anne Hospital, INSERM 894, DHU NeuroVasc Sorbonne Paris-Cité, Paris Descartes University, Paris, France (JLM), Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (VC), Department of Neurology, Charité, Universitätsmedizin Berlin, Berlin, Germany (EM), on behalf of the European Stroke Science Workshop Presenters and Co-convenors, INSERM U1161, UFR de médecine Paris Diderot, France (ETL), Department of Neurology, Cologne University Hospital, Köln, Germany (CG), HRB Stroke Clinical Trials Network Ireland, University College Dublin Ireland (PJK), University of Glasgow, Queen Elizabeth University Hospital, Glasgow, United Kingdom (KM), Dept of Internal Medicine, Oslo University Hospital, Oslo, and Institute of Clinical Medicine, University of Tromsø, Tromsø, Norway (EB), Sorbonne Universités, UPMC Université, Paris 06, INSERM UMR-S 1166, F-75013, Paris, France (DAT), ICAN Institute for Cardiometabolism and Nutrition, Paris, France (DAT), University Hospital of North Midlands NHS Trust, Stoke-on-Trent, United Kingdom (CR), Department Neurosciences and Preventive Medicine, Danube University Krems, Austria (MB), Department of Neurosurgery, Bern University Hospital, Inselspital, Bern, Switzerland (JB), Department of Neurology, University of Heidelberg, Heidelberg, Germany (TS), Department of Neurology, Slotervaart Medical Center, Amsterdam, The Netherlands (LMdL), University Paris Diderot, Paris, France (EJ), Department of Neurology, University of Heidelberg, Heidelberg, Germany (RV), and Department of Neurology, Hopital Sainte-Anne, Université
Subjects: Stroke, small vessel disease, stroke therapy, thrombectomy, genomics, Clinical Neurology, stroke recovery, Cardiology and Cardiovascular Medicine, intracerebral hemorrhage, vascular cognitive impairment
Abstract: Lake Eibsee, Garmisch-Partenkirchen, 16 to 18 November, 2017: The European Stroke Organisation convened >120 stroke experts from 21 countries to discuss latest results and hot topics in clinical, translational and basic stroke research. Since its inception in 2011, the European Stroke Science Workshop has become a cornerstone of European Stroke Organisation’s academic activities and a major highlight for researchers in the field. Participants include stroke researchers at all career stages and with different backgrounds, who convene for plenary lectures and discussions. The workshop was organised in seven scientific sessions focusing on the following topics: (1) acute stroke treatment and endovascular therapy; (2) small vessel disease; (3) opportunities for stroke research in the omics era; (4) vascular cognitive impairment; (5) intracerebral and subarachnoid haemorrhage; (6) alternative treatment concepts and (7) neural circuits, recovery and rehabilitation. All sessions started with a keynote lecture providing an overview on current developments, followed by focused talks on a timely topic with the most recent findings, including unpublished data. In the following, we summarise the key contents of the meeting. The program is provided in the online only Data Supplement. The workshop started with a key note lecture on how to improve the efficiency of clinical trial endpoints in stroke, which was delivered by Craig Anderson (Sydney, Australia) and set the scene for the following discussions.
Published: 2018

11. Enhancing rare earth element transfer from phosphate rock to phosphoric acid using an inexpensive fly ash additive

Author: Mohammed Hakkar, Mohammed Benjelloun, Amit Roy, Essaïd Bilal, Ahmed Mahrou, Hamid Mazouz, Nils Haneklaus, Fatima Ezzahra Arhouni, Martin Bertau, Aziz Boukhair, Gerald Steiner, Department of Physics, Université Chouaib Doukkali (UCD), Département Procédés pour l'Environnement et Géoressources (PEG-ENSMSE), Centre Sciences des Processus Industriels et Naturels (SPIN-ENSMSE), École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Environnement, Ville, Société (EVS), École normale supérieure de Lyon (ENS de Lyon)-École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université Lumière - Lyon 2 (UL2)-Université Jean Moulin - Lyon 3 (UJML), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-École Nationale des Travaux Publics de l'État (ENTPE)-École nationale supérieure d'architecture de Lyon (ENSAL)-Centre National de la Recherche Scientifique (CNRS), Freiberg University of Mining and Technology, Institute of Chemical Technology, Global Phosphorus Institute (GPI), Td Lab Sustainable Mineral Resources, Danube University Krems, Complexity Science Hub Vienna (CSHV), Groupe OCP, Regional Center of the Trades of Education and Training, Faculty of Sciences - Chouaib Doukkali University, Institute of Chemical Technology - Freiberg University of Mining and Technology, Global Phosphorus Institute, Danube University Krems - Td Lab Sustainable Mineral Resources, Complexity Science Hub Vienna, OCP Group S.A, Faculty of Sciences, Chouaib Doukkali University, El Jadida 24000, Morocco, Environnement Ville Société (EVS), École normale supérieure - Lyon (ENS Lyon)-École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), and Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet [Saint-Étienne] (UJM)-École Nationale des Travaux Publics de l'État (ENTPE)-École nationale supérieure d'architecture de Lyon (ENSAL)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Unconventional Resources, 0211 other engineering and technologies, chemistry.chemical_element, Fraction (chemistry), Phosphogypsum, 02 engineering and technology, 010403 inorganic & nuclear chemistry, 01 natural sciences, chemistry.chemical_compound, Fly Ash Additive, Khouribga, [SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering, Phosphoric acid, Wet Phosphoric Acid (WPA), 021102 mining & metallurgy, Rare-earth element, Mechanical Engineering, Phosphate Rock, General Chemistry, Yttrium, Geotechnical Engineering and Engineering Geology, 0104 chemical sciences, Morocco, chemistry, Phosphorite, 13. Climate action, Control and Systems Engineering, Fly ash, Fluoride, Rare Earths Recovery, Nuclear chemistry
Abstract: International audience; Adding active silica (SiO2) to reduce the free fluoride content is a known method to improve the filterability of phosphogypsum (PG) during wet phosphoric acid (WPA) processing of phosphate rock (PR). Besides, this process can also promote the transfer of valuable rare earth elements (REE) from the PR into the liquid phosphoric acid (PA) stream rather than into the solid PG matrix from which later economic recovery is more challenging. Khouribga PR, that shows total REE concentrations of 577 ppm (328 ppm heavy REE and 249 ppm light REE) of which yttrium (Y) with 240 ppm constitutes the major fraction, is processed at the Jorf Lasfar El-Jadida chemical complex in Morocco that is also home to the country’s largest coal power plant. Fly ash produced during thermal power production, 70% of which is stacked in the immediate vicinity, presently remains mostly unused and consists largely (48%) of silica. In this work the use of fly ash (34 kg per t PR) and pure silica (8.5 kg per t PR) on the transfer of REE from Khouribga PR into the PA and PG stream during dihydrate WPA production was examined. The inexpensive fly ash/silica additive increases the transfer of various REE to the PA stream. For Y an increase of 37% was measured that resulted in a concentration of 48 ppm in the PA stream prior to further concentration by evaporation.
Published: 2021
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12. Thermal Beneficiation of Sra Ouertane (Tunisia) Low-Grade Phosphate Rock

Author: Noureddine Abbes, Nils Haneklaus, Gerald Steiner, Essaïd Bilal, Ludwig Hermann, GROUPE CHIMIQUE TUNISIEN (GCT), Département Procédés pour l'Environnement et Géoressources (PEG-ENSMSE), Centre Sciences des Processus Industriels et Naturels (SPIN-ENSMSE), École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Environnement Ville Société (EVS), École normale supérieure - Lyon (ENS Lyon)-École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université Lumière - Lyon 2 (UL2)-Université Jean Moulin - Lyon 3 (UJML), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet [Saint-Étienne] (UJM)-École Nationale des Travaux Publics de l'État (ENTPE)-École nationale supérieure d'architecture de Lyon (ENSAL)-Centre National de la Recherche Scientifique (CNRS), Proman Management GmbH, Partenaires INRAE, Td Lab Sustainable Mineral Resources, Danube University Krems, Groupe Chimique Tunisien, Td Lab Sustainable Mineral Resources, Danube University Krems, Environnement, Ville, Société (EVS), École normale supérieure de Lyon (ENS de Lyon)-École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), and Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-École Nationale des Travaux Publics de l'État (ENTPE)-École nationale supérieure d'architecture de Lyon (ENSAL)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Thermogravimetric analysis, Tunisia, lcsh:QE351-399.2, Thermal treatment, 010501 environmental sciences, 010502 geochemistry & geophysics, 01 natural sciences, calcination, Sra Ouertane, law.invention, Metal, chemistry.chemical_compound, MESH: 10.3390/min10110937, law, [SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering, Calcination, 0105 earth and related environmental sciences, Quenching, lcsh:Mineralogy, Chemistry, thermal beneficiation, Geology, Geotechnical Engineering and Engineering Geology, Phosphate, low-grade phosphate rock, Phosphorite, visual_art, visual_art.visual_art_medium, Powder diffraction, Nuclear chemistry
Abstract: International audience; Low-grade phosphate rock from Sra Ouertane (Tunisia) was beneficiated using a thermal treatment consisting of calcination, quenching, and disliming. Untreated phosphate rock samples (group 1), calcined phosphate rock samples (group 2), as well as calcined, quenched, and dislimed (group 3) phosphate rock samples, were investigated using inductively-coupled plasma atomic emission spectroscopy (ICP-AES), inductively-coupled plasma mass spectrometry (ICP-MS), thermogravimetric analysis (TGA), and X-ray powder diffraction (XRD). Besides, the particle sizedistribution of the aforementioned three groups was determined. The proposed thermal treatment successfully increased the P2O5 content of the untreated phosphate rock from 20.01 wt% (group 1) to 24.24 wt% (group 2) after calcination and, finally, 27.24 wt% (group 3) after calcination, quenching, and disliming. It was further found that the concentration of relevant accompanying rare earth elements (Ce, La, Nd, Pr, Sm, and Y) was increased and that the concentration of Cd could be significantly reduced from 30 mg/kg to 14 mg/kg with the proposed treatment. The resulting phosphate concentrate showed relatively high concentrations in metal oxides: &#931 MgO, Fe2O3, Al2O3 = 3.63 wt% and silica (9.81 wt%) so that it did not meet the merchant grade specifications of a minimum P2O5 content of 30 wt% yet. Removal of these elements could be achieved using additional appropriate separation techniques.
Published: 2020
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13. Exhaled breath condensate as bioanalyte: from collection considerations to biomarker sensing

Author: Sabine Szunerits, Hannes Dӧrfler, Quentin Pagneux, John Daniel, Shekhar Wadekar, Eloise Woitrain, Dennis Ladage, David Montaigne, Rabah Boukherroub, Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Université catholique de Lille (UCL)-Université catholique de Lille (UCL), NanoBioInterfaces - IEMN (NBI - IEMN), Université catholique de Lille (UCL)-Université catholique de Lille (UCL)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Danube University Krems, Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires - U1011 (RNMCD), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Institut Européen de Génomique du Diabète - European Genomic Institute for Diabetes - FR 3508 (EGID), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), This work received financial support from the Centre National de la Recherche Scientifique (CNRS) and the University of Lille., Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 [IEMN], NanoBioInterfaces - IEMN [NBI - IEMN], Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires [RNMCD - U1011], and Centre Hospitalier Régional Universitaire [Lille] [CHRU Lille]
Subjects: [PHYS]Physics [physics], [SPI]Engineering Sciences [physics], Biochemistry, Analytical Chemistry
Abstract: International audience; Since the SARS-CoV-2 pandemic, the potential of exhaled breath (EB) to provide valuable information and insight into the health status of a person has been revisited. Mass spectrometry (MS) has gained increasing attention as a powerful analytical tool for clinical diagnostics of exhaled breath aerosols (EBA) and exhaled breath condensates (EBC) due to its high sensitivity and specificity. Although MS will continue to play an important role in biomarker discovery in EB, its use in clinical setting is rather limited. EB analysis is moving toward online sampling with portable, room temperature operable, and inexpensive point-of-care devices capable of real-time measurements. This transition is happening due to the availability of highly performing biosensors and the use of wearable EB collection tools, mostly in the form of face masks. This feature article will outline the last developments in the field, notably the novel ways of EBA and EBC collection and the analytical aspects of the collected samples. The inherit non-invasive character of the sample collection approach might open new doors for efficient ways for a fast, non-invasive, and better diagnosis.
Published: 2023
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14. [Review] Graphene-based field-effect transistors for biosensing:where is the field heading to?

Author: Szunerits, Sabine, Rodrigues, Teresa, Bagale, Rupali, Happy, Henri, Boukherroub, Rabah, Knoll, Wolfgang, Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 [IEMN], NanoBioInterfaces - IEMN [NBI - IEMN], Austrian Institute of Technology [Vienna] [AIT], Carbon - IEMN [CARBON - IEMN], Danube University Krems, Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Université catholique de Lille (UCL)-Université catholique de Lille (UCL), NanoBioInterfaces - IEMN (NBI - IEMN), Université catholique de Lille (UCL)-Université catholique de Lille (UCL)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Austrian Institute of Technology [Vienna] (AIT), Carbon - IEMN (CARBON - IEMN), Financial support from the Centre National de la Recherche Scientifique (CNRS), the University of Lille, and the ANR PADISC (ANR-20- CE19-0021) is received. Support by EuroNanoMed III (GSkin) is also acknowledged., and ANR-20-CE19-0021,PADISC,Pansements Actifs intégrant des Capteurs Électroniques embarqués graphène pour la Détection In-Situ De l'Infection et le Suivi de la Cicatrisation(2020)
Subjects: Field-efect transistor, [PHYS]Physics [physics], [SPI]Engineering Sciences [physics], Sensing, Graphene, Bioreceptors
Abstract: International audience; Two-dimensional (2D) materials hold great promise for future applications, notably their use as biosensing channels in the field-effect transistor (FET) configuration. On the road to implementing one of the most widely used 2D materials, graphene, in FETs for biosensing, key issues such as operation conditions, sensitivity, selectivity, reportability, and economic viability have to be considered and addressed correctly. As the detection of bioreceptor-analyte binding events using a graphene-based FET (gFET) biosensor transducer is due to either graphene doping and/or electrostatic gating effects with resulting modulation of the electrical transistor characteristics, the gFET configuration as well as the surface ligands to be used have an important influence on the sensor performance. While the use of back-gating still grabs attention among the sensor community, top-gated and liquid-gated versions have started to dominate this area. The latest efforts on gFET designs for the sensing of nucleic acids, proteins and virus particles in different biofluids are presented herewith, highlighting the strategies presently engaged around gFET design and choosing the right bioreceptor for relevant biomarkers.
Published: 2023
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15. Fatty acid composition differs between emergent aquatic and terrestrial insects : a detailed single system approach

Author: Tarn Preet Parmar, Alina L. Kindinger, Margaux Mathieu-Resuge, Cornelia W. Twining, Jeremy Ryan Shipley, Martin J. Kainz, Dominik Martin-Creuzburg, Univ Konstanz, Inst Limnol, Dept Biol, D-78457 Constance, Germany, WasserCluster Lunz, Interuniversity Center for Aquatic Ecosystem Research, Laboratoire des Sciences de l'Environnement Marin (LEMAR) (LEMAR), Institut de Recherche pour le Développement (IRD)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Université de Brest (UBO)-Institut Universitaire Européen de la Mer (IUEM), Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Brest (UBO)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Brest (UBO)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Dynamique et durabilité des écosystèmes : de la source à l’océan (DECOD), Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Max Planck Society, Swiss Federal Insitute of Aquatic Science and Technology [Dübendorf] (EAWAG), University of Natural Resources and Applied Life Sciences, Vienna, (BOKU) and Competence Centre Wood K plus, Danube University Krems, and Brandenburg University of Technology [Cottbus – Senftenberg] (BTU)
Subjects: [SDV.EE]Life Sciences [q-bio]/Ecology, environment, eicosapentaenoic acid, Ecology, seasonality, Diptera, easonality, aquatic subsidies, alpha-linolenic acid, insect emergence, Alpha-linolenic acid, aquatic subsidies, arachidonic acid, Diptera, eicosapentaenoic acid, insect emergence, seasonality, ddc:570, arachidonic acid, Ecology, Evolution, Behavior and Systematics, insect emergences
Abstract: International audience; Emergent insects represent a key vector through which aquatic nutrients are transferred to adjacent terrestrial food webs. Aquatic fluxes of polyunsaturated fatty acids (PUFA) from emergent insects are particularly important subsidies for terrestrial ecosystems due to high PUFA contents in several aquatic insect taxa and their physiological importance for riparian predators. While recent meta-analyses have shown the general dichotomy in fatty acid profiles between aquatic and terrestrial ecosystems, differences in fatty acid profiles between aquatic and terrestrial insects have been insufficiently explored. We examined the differences in fatty acid profiles between aquatic and terrestrial insects at a single aquatic-terrestrial interface over an entire growing season to assess the strength and temporal consistency of the dichotomy in fatty acid profiles. Non-metric multidimensional scaling clearly separated aquatic and terrestrial insects based on their fatty acid profiles regardless of season. Aquatic insects were characterized by high proportions of long-chain PUFA, such as eicosapentaenoic acid (20:5n-3), arachidonic acid (20:4n-6), and α-linolenic acid (18:3n-3); whereas terrestrial insects were characterized by high proportions of linoleic acid (18:2n-6). Our results provide detailed information on fatty acid profiles of a diversity of aquatic and terrestrial insect taxa and demonstrate that the fundamental differences in fatty acid content between aquatic and terrestrial insects persist throughout the growing season. However, the higher fatty acid dissimilarity between aquatic and terrestrial insects in spring and early summer emphasizes the importance of aquatic emergence as essential subsidies for riparian predators especially during the breading season.
Published: 2022
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16. The ecological role of permanent ponds in Europe: a review of dietary linkages to terrestrial ecosystems via emerging insects

Author: Lena Fehlinger, Benjamin Misteli, Daniel Morant, Noël Juvigny-Khenafou, David Cunillera-Montcusí, Fernando Chaguaceda, Olivera Stamenković, Julie Fahy, Vojtěch Kolář, Dariusz Halabowski, Liam N. Nash, Ellinor Jakobsson, Veronica Nava, Pietro Tirozzi, Pablo Urrutia Cordero, Julien Mocq, Alba Camacho Santamans, Jose Manuel Zamora-Marín, Pierre Marle, Teofana Chonova, Luca Bonacina, Margaux Mathieu-Resuge, Ena Suarez, Stephen E. Osakpolor, Pablo Timoner, Vesela Evtimova, Darmina Nita, Bruno M. Carreira, Kálmán Tapolczai, Joana Martelo, Rémi Gerber, Valentin Dinu, Jorge Henriques, Géza B. Selmeczy, Biljana Rimcheska, Fehlinger, L, Misteli, B, Morant, D, Juvigny-Khenafou, N, Cunillera-Montcusí, D, Chaguaceda, F, Stamenković, O, Fahy, J, Kolář, V, Halabowski, D, Nash, L, Jakobsson, E, Nava, V, Tirozzi, P, Cordero, P, Mocq, J, Santamans, A, Zamora, J, Marle, P, Chonova, T, Bonacina, L, Mathieu-Resuge, M, Suarez, E, Osakpolor, S, Timoner, P, Evtimova, V, Nita, D, Carreira, B, Tapolczai, K, Martelo, J, Gerber, R, Dinu, V, Henriques, J, Selmeczy, G, Rimcheska, B, Repositório da Universidade de Lisboa, Danube University Krems, Ecosystèmes, biodiversité, évolution [Rennes] (ECOBIO), Université de Rennes (UR)-Institut Ecologie et Environnement (INEE), Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Rennes (OSUR), Université de Rennes (UR)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Centre National de la Recherche Scientifique (CNRS), RiverLy - Fonctionnement des hydrosystèmes (RiverLy), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Équipe 1 - Biodiversité et Adaptation dans les Hydrosystèmes (BAH), Laboratoire d'Ecologie des Hydrosystèmes Naturels et Anthropisés (LEHNA), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-École Nationale des Travaux Publics de l'État (ENTPE)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-École Nationale des Travaux Publics de l'État (ENTPE)-Centre National de la Recherche Scientifique (CNRS), Centre Alpin de Recherche sur les Réseaux Trophiques et Ecosystèmes Limniques (CARRTEL), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Bulgarian Academy of Sciences (BAS), and The EUROPONDS project was awarded as '3rd fresh project' (2020 - 2022) by the European Federation of Freshwater Sciences (EFFS), European Fresh and Young Researchers (EFYR), and representatives of the Fresh Blood for Fresh Water (FBFW). The funding is provided by the contributing EFFS societies: Association Française de Limnologie (AFL), Association of Austrian SIL Members (SIL Austria), Associazione Italiana di Oceanologia e Limnologia (AIOL), Asociación Ibérica de Limnología/Associação Ibérica de Limnologia (AIL), Deutsche Gesellschaft für Limnologie e.V. (DGL), Freshwater Biological Association (FBA), Hrvatsko Udruženje Slatkovodnih Ekologa (HUSEK), Magyar Hidrológiai Társaság (MHT), Polskie Towarzystwo Hydrobiologiczne (PTH), Schweizerische Gesellschaft für Hydrologie und Limnologie/Société Suisse d'Hydrologie et de Limnologie/Società Svizzera di Idrologia e Limnologia (SSHL).
Subjects: dietary subsidies, dietary subsidie, Ietary subsidies, Emergence of insects, Aquatic Science, small waterbodie, emergence of insects, aquatic insect, Small water bodies, pondscape, Aquatic insects, [SDE]Environmental Sciences, aquatic insects, emergence of insect, Water Science and Technology, small water bodies, biodiversity
Abstract: International audience; Permanent ponds are valuable freshwater systems and biodiversity hotspots. They provide diverse ecosystem services (ES), including water quality improvement and supply, food provisioning and biodiversity support. This is despite being under significant pressure from multiple anthropogenic stressors and the impacts of ongoing global change. However, ponds are largely overlooked in management plans and legislation, and ecological research has focused on large freshwater ecosystems, such as rivers or lakes. Protection of ponds is often insufficient or indirectly provided via associated habitats such as wetlands. This phenomenon is likely exacerbated due to lacking a full-scale understanding of the importance of ponds. In this review, we provided a detailed overview of permanent ponds across Europe, including their usages and the biodiversity they support. By discussing the concepts of pondscape and metacommunity theory, we highlighted the importance of connectivity among and between ponds and identified fluxes of emerging insects as another ES of ponds. Those insects are rich in essential nutrients such as polyunsaturated fatty acids (PUFA), which are delivered through them to the terrestrial environment, however the extent and impact of this ES remains largely unexplored. Several potential stressors, especially related to ongoing global change, which influence pond diversity and integrity were discussed. To conclude this review, we provided our insights on future pond management. Adaptive measures, taking into account the pond system per se within the pondscape, were found to be the most promising to mitigate the loss of natural ponds and restore and conserve natural small water bodies as refuges and diversity hotspots in increasingly urbanized landscapes.
Published: 2022
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17. La géphyrine interagit avec le co-transporteur K-Cl KCC2 pour réguler son expression de surface et sa fonction dans les neurones corticaux

Author: Al Awabdh, Sana, Donneger, Florian, Goutierre, Marie, Séveno, Martial, Vigy, Oana, Weinzettl, Pauline, Russeau, Marion, Moutkine, Imane, Lévi, Sabine, Marin, Philippe, Poncer, Jean, Institut du Fer à Moulin (IFM - Inserm U1270 - SU), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), BioCampus (BCM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Institut de Génomique Fonctionnelle (IGF), Danube University Krems, Poncer, Jean Christophe, BioCampus Montpellier (BCM), Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), and Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS)
Subjects: proteomics, chloride, KCC2, cerebral cortex, synaptic transmission, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], GABA transmission, ComputingMilieux_MISCELLANEOUS
Abstract: International audience; The K+-Cl- cotransporter KCC2, encoded by the Slc12a5 gene, is a neuron-specific chloride extruder that tunes the strength and polarity of GABAA receptor-mediated transmission. In addition to its canonical ion transport function, KCC2 also regulates spinogenesis and excitatory synaptic function through interaction with a variety of molecular partners. KCC2 is enriched in the vicinity of both glutamatergic and GABAergic synapses, the activity of which in turn regulates its membrane stability and function. KCC2 interaction with the submembrane actin cytoskeleton via 4.1N is known to control its anchoring near glutamatergic synapses on dendritic spines. However, the molecular determinants of KCC2 clustering near GABAergic synapses remain unknown. Here, we used proteomics to identify novel KCC2 interacting proteins in the adult rat neocortex. We identified both known and novel candidate KCC2 partners, including some involved in neuronal development and synaptic transmission. These include gephyrin, the main scaffolding molecule at GABAergic synapses. Gephyrin interaction with endogenous KCC2 was confirmed by immunoprecipitation from rat neocortical extracts. We showed that gephyrin stabilizes plasmalemmal KCC2 and promotes its clustering in hippocampal neurons, mostly but not exclusively near GABAergic synapses, thereby controlling KCC2-mediated chloride extrusion. This study identifies gephyrin as a novel KCC2 anchoring molecule that regulates its membrane expression and function in cortical neurons.SIGNIFICANCE STATEMENT Fast synaptic inhibition in the brain is mediated by chloride-permeable GABAA receptors (GABAARs) and therefore relies on transmembrane chloride gradients. In neurons, these gradients are primarily maintained by the K/Cl cotransporter KCC2. Therefore, understanding the mechanisms controlling KCC2 expression and function is crucial to understand its physiological regulation and rescue its function in the pathology. KCC2 function depends on its membrane expression and clustering, but the underlying mechanisms remain unknown. We describe the interaction between KCC2 and gephyrin, the main scaffolding protein at inhibitory synapses. We show that gephyrin controls plasmalemmal KCC2 clustering and that loss of gephyrin compromises KCC2 function. Our data suggest functional units comprising GABAARs, gephyrin, and KCC2 act to regulate synaptic GABA signaling.
Published: 2022
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18. Assessment of large critical electric field in ultra-wide bandgap p-type spinel ZnGa2O4

Author: Zeyu Chi, Tamar Tchelidze, Corinne Sartel, Tsotne Gamsakhurdashvili, Ismail Madaci, Hayate Yamano, Vincent Sallet, Yves Dumont, Amador Pérez-Tomás, Farid Medjdoub, Ekaterine Chikoidze, Groupe d'Etude de la Matière Condensée (GEMAC), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Danube University Krems, ICN2 - Institut Catala de Nanociencia i Nanotecnologia (ICN2), Universitat Autònoma de Barcelona (UAB), Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Université catholique de Lille (UCL)-Université catholique de Lille (UCL), WIde baNd gap materials and Devices - IEMN (WIND - IEMN), Université catholique de Lille (UCL)-Université catholique de Lille (UCL)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), The present work is a part of 'GALLIA' International Research Project, CNRS, France. GEMaCcolleagues acknowledge financial support of French National Agency of Research (ANR), project'GOPOWER', CE-50 N0015-01. The ICN2 is funded by the CERCA programme / Generalitat deCatalunya and by the Severo Ochoa programme of the Spanish Ministry of Economy, Industry andCompetitiveness (MINECO, grant no. SEV-2017-0706)., Renatech Network, CMNF, and ANR-21-CE50-0015,GOPOWER,Accélérer la démonstration du potentiel de l'Oxyde de Gallium pour les applications du domaine de l'énergie(2021)
Subjects: [PHYS]Physics [physics], [SPI]Engineering Sciences [physics], Acoustics and Ultrasonics, Condensed Matter Physics, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials
Abstract: The spinel zinc gallate ZnGa2O4 stands out among the emerging ultra-wide bandgap (∼5 eV) semiconductors as the ternary complex oxide with the widest gap where bipolar conductivity has been demonstrated. For power and energy electronics, a fundamental property of the material is its critical electric field ( E CR ) although, for ZnGa2O4, is yet unknown. In this work, highly resistive p-type ZnGa2O4 thin films on sapphire and Si substrates were grown by metal organic chemical vapor deposition to determine both, the remote acceptor concentration and vertical breakdown voltage. Hall Effect measurements confirmed a low carrier concentration at room temperature of ∼1011 cm−3. From vertical metal-semiconductor-metal structures the average E CR has been estimated to be of at least 5.3 MV cm−1, which already is significantly larger than the one of SiC and GaN.
Published: 2023
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19. Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability

Author: Tove Fall, Anubha Mahajan, Dmitry Shungin, B. Balkau, Gerjan Navis, A. Metspalu, Anneli Pouta, Andrew A. Hicks, Ilja M. Nolte, Ian Ford, Aroon D. Hingorani, Stefan R Bornstein, Anuj Goel, Rona J. Strawbridge, Niek Verweij, Sarah H. Wild, Patricia B. Munroe, T.B. Harris, Jaana Lindström, Johnson Pcd., Nita G. Forouhi, Pierre Meneton, Patricia A. Peyser, Sarin A-P., Andrea Ganna, Timothy M. Frayling, Patrik K. E. Magnusson, Joanne M. Meyer, Yongmei Liu, Jeanette M. Stafford, Christian Herder, L Zudina, Maria G. Stathopoulou, May E. Montasser, Nicholas D. Hastie, Inês Barroso, Schwarz Peh., James B. Meigs, Perttu Salo, George Davey Smith, Gonneke Willemsen, Christopher J. Groves, Erik P A Van Iperen, M. A. Province, Veikko Salomaa, Naveed Sattar, Serena Sanna, Maria Dimitriou, Joop Jukema, Ulrika Krus, Albert V. Smith, Markku Laakso, James F. Wilson, George Nicholson, Loic Yengo, Tatijana Zemunik, Per Eriksson, Harold Snieder, Peter P. Pramstaller, Claudia Langenberg, R. Rauramaa, Alan R. Shuldiner, Pau Navarro, Veronique Vitart, Ross M. Fraser, Aaron Isaacs, C. Lecoeur, Jesper R. Gådin, Jackie F. Price, Letizia Marullo, L.F. Bielak, Sirkka Keinänen-Kiukaanniemi, Amélie Bonnefond, Michael Stumvoll, Alessia Faggian, Anke Tönjes, Tomohiro Tanaka, Wieland Kiess, Harry Campbell, Josée Dupuis, David Altshuler, João Fadista, Winfried März, G K Hovingh, Thomas Illig, Toby Johnson, H Grallert, Kari Stefansson, Reedik Mägi, Palmer Cna., de Geus Ejcn., Martina Müller-Nurasyid, Karen Kapur, Philippe Froguel, Dorret I. Boomsma, Anders Franco-Cereceda, Marcus E. Kleber, Boehnke M, Olga D. Carlson, Ozren Polasek, Andrew P. Morris, Alex S. F. Doney, Najaf Amin, Sara M. Willems, Vilmundur Gudnason, Jose C. Florez, Jeffery R. O'Connell, Nancy L. Pedersen, T. Saaristo, Wolffenbuttel Bhr., M. I. J. Uusitupa, Longda Jiang, Iva Miljkovic, James S. Pankow, Caroline Hayward, Hugh Watkins, Vasiliki Lagou, Johanna Kuusisto, Jaakko Tuomilehto, Alan F. Wright, Josephine M. Egan, Perry Jrb., C M van Duijn, Valeriya Lyssenko, Leif Groop, Stefania Bandinelli, Nigel W. Rayner, Tõnu Esko, Stela McLachlan, Momoko Horikoshi, Eric Boerwinkle, Rick Jansen, Richard N. Bergman, Gudmar Thorleifsson, Lyle J. Palmer, Vilmantas Giedraitis, Peter Kovacs, Nicholas J. Wareham, Luigi Ferrucci, N J Timpson, D Rybin, Anne U. Jackson, Tiinamaija Tuomi, Gonçalo R. Abecasis, Harst Pvd., Meena Kumari, Albert Hofman, Chiara Scapoli, Evelin Mihailov, Josine L. Min, Anders Hamsten, Hottenga J-J., Loos Rjf., Lars Lind, Ulf de Faire, Jaakko Kaprio, Guo Li, Beate St Pourcain, C Gieger, Amanda J. Bennett, Anna Ulrich, Nabila Bouatia-Naji, Satu Männistö, Antigone S. Dimas, Jarvelin M-R., Günther Silbernagel, F Karpe, A. Körner, David S. Siscovick, M Blüher, Rebecca J. Webster, Erik Ingelsson, Susan Campbell, Mika Kivimäki, Laura J. Rasmussen-Torvik, Heikki A. Koistinen, Sophie Visvikis-Siest, Bernhard O. Boehm, Inga Prokopenko, Ping An, Emmanouil T. Dermitzakis, Cecilia M. Lindgren, Kardia Slr., Richa Saxena, Igor Rudan, Richard M. Watanabe, Jian'an Luan, Marika Kaakinen, Shin S-Y., George Dedoussis, Panagiotis Deloukas, Mark I. McCarthy, Barbara Thorand, B.W.J.H. Penninx, Peter Vollenweider, Paul W. Franks, Leena Kinnunen, Markus Perola, Yvonne Boettcher, Timo A. Lakka, Nicole Soranzo, Stavroula Kanoni, Bakker Sjl., Winkelmann Br, The Wellcome Trust Centre for Human Genetics [Oxford], University of Oxford [Oxford], Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Institute of Genomics [Tartu, Estonia], University of Tartu, Vrije Universiteit Amsterdam [Amsterdam] (VU), Vrije Universiteit Medical Centre (VUMC), Helmholtz-Zentrum München (HZM), University of Cambridge [UK] (CAM), Metabolic functional (epi)genomics and molecular mechanisms involved in type 2 diabetes and related diseases - UMR 8199 - UMR 1283 (GI3M), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Paris-Centre de Recherche Cardiovasculaire (PARCC (UMR_S 970/ U970)), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Università degli Studi di Ferrara (UniFE), Boston University [Boston] (BU), VU University Medical Center [Amsterdam], University of Bristol [Bristol], Biomedical Sciences Research Centre Alexander Fleming [Vari, Greece] (BSRC), Imperial College London, Karolinska Institutet [Stockholm], Institute for Molecular Bioscience, University of Queensland [Brisbane], Statens Serum Institut [Copenhagen], Interactions Gène-Environnement en Physiopathologie Cardio-Vasculaire (IGE-PCV), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Erasmus University Medical Center [Rotterdam] (Erasmus MC), Cardiovascular Research Institute Maastricht (CARIM), Maastricht University [Maastricht], MRC Institute of Genetics and Molecular Medicine [Edinburgh] (IGMM), University of Edinburgh-Medical Research Council, National Institute on Aging [Baltimore, MD, USA] (NIH), University of Michigan [Ann Arbor], University of Michigan System, University of Maryland School of Medicine, University of Maryland System, The University of Western Australia (UWA), Broad Institute of MIT and Harvard (BROAD INSTITUTE), Harvard Medical School [Boston] (HMS)-Massachusetts Institute of Technology (MIT)-Massachusetts General Hospital [Boston], Massachusetts General Hospital [Boston], Harvard Medical School [Boston] (HMS), Wake Forest University, National Institute for Health and Welfare [Helsinki], The Wellcome Trust Sanger Institute [Cambridge], University of Iceland [Reykjavik], University of Washington [Seattle], University of Groningen [Groningen], University of Glasgow, William Harvey Research Institute, Barts and the London Medical School, Université de Lausanne (UNIL), deCODE genetics [Reykjavik], Northwestern University Feinberg School of Medicine, Uppsala Universitet [Uppsala], University of Edinburgh, Medical Faculty [Mannheim], University of Graz, Ludwig-Maximilians-Universität München (LMU), Johannes Gutenberg - Universität Mainz (JGU), Institute for Molecular Medicine Finland [Helsinki] (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki-University of Helsinki, Umeå University, Skane University Hospital [Malmo], Lund University [Lund], RIKEN Center for Integrative Medical Sciences [Yokohama] (RIKEN IMS), RIKEN - Institute of Physical and Chemical Research [Japon] (RIKEN), Washington University School of Medicine in St. Louis, Washington University in Saint Louis (WUSTL), Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche [Roma] (CNR), University Medical Center Groningen [Groningen] (UMCG), Universität Leipzig [Leipzig], Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), University of Split, Academic Medical Center - Academisch Medisch Centrum [Amsterdam] (AMC), University of Amsterdam [Amsterdam] (UvA), University of Eastern Finland, Harokopio University of Athens, European Academy Bozen/Bolzano (EURAC), University of Kuopio, German Center for Diabetes Research - Deutsches Zentrum für Diabetesforschung [Neuherberg] (DZD), University of Pittsburgh (PITT), Pennsylvania Commonwealth System of Higher Education (PCSHE), Ninewells Hospital and Medical School [Dundee], University College of London [London] (UCL), University of Essex, Heinrich Heine Universität Düsseldorf = Heinrich Heine University [Düsseldorf], University of Helsinki, Leiden University Medical Center (LUMC), Institute of Cardiovascular and Medical Sciences [Glasgow], University of Oulu, The University of Texas Health Science Center at Houston (UTHealth), University of Minnesota Medical School, University of Minnesota System, Keck School of Medicine [Los Angeles], University of Southern California (USC), Amsterdam UMC, University Hospital Carl Gustav Carus [Dresden, Germany], Technische Universität Dresden = Dresden University of Technology (TU Dresden), Lee Kong Chian School of Medicine, Nanyang Technological University (NTU), Universität Heidelberg [Heidelberg], King Abdulaziz University, Pirkanmaa Hospital District, Tampere University Hospital, Cedars-Sinai Medical Center, Danube University Krems, Harvard School of Public Health, Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Institute of Epidemiology [Neuherberg] (EPI), German Research Center for Environmental Health - Helmholtz Center München (GmbH), Hannover Medical School [Hannover] (MHH), Universität zu Lübeck [Lübeck], University of Exeter, Regeneron Pharmaceuticals [Tarrytown], University of Adelaide, Centre de Recherche des Cordeliers (CRC (UMR_S 872)), Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), National Institute on Aging [Bethesda, USA] (NIA), National Institutes of Health [Bethesda] (NIH), Icahn School of Medicine at Mount Sinai [New York] (MSSM), Harvard T.H. Chan School of Public Health, John Radcliffe Hospital [Oxford University Hospital], Centre Hospitalier Universitaire Vaudois [Lausanne] (CHUV), Université de Genève (UNIGE), Big Data Institute, University of Surrey (UNIS), University of Bergen (UiB), Stanford School of Medicine [Stanford], Stanford Medicine, Stanford University-Stanford University, Stanford Cardiovascular Institute, University of Liverpool, University of Manchester [Manchester], Institute of Biochemistry and Genetics of Ufa Scientific Centre, Russian Academy of Sciences [Moscow] (RAS), Experimental Vascular Medicine, Vascular Medicine, ACS - Atherosclerosis & ischemic syndromes, SIEST, Sofia, PreciDIAB Institute, the holistic approach of personal diabets care - - PreciDIAB2018 - ANR-18-IBHU-0001 - IBHU - VALID, Understanding the dynamic determinants of glucose homeostasis and social capability to promote Healthy and active aging - DYNAHEALTH - - H20202015-04-01 - 2019-03-31 - 633595 - VALID, Beyond the Genetics of Addiction - ADDICTION - - EC:FP7:ERC2011-12-01 - 2017-05-31 - 284167 - VALID, Rise of scientific excellence and collaboration for implementing personalised medicine in Estonia - ePerMed - - H20202016-01-01 - 2018-12-31 - 692145 - VALID, University of Oxford, Helmholtz Zentrum München = German Research Center for Environmental Health, Metabolic functional (epi)genomics and molecular mechanisms involved in type 2 diabetes and related diseases - UMR 8199 - UMR 1283 (EGENODIA (GI3M)), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Università degli Studi di Ferrara = University of Ferrara (UniFE), Université de Lausanne = University of Lausanne (UNIL), Karl-Franzens-Universität Graz, Johannes Gutenberg - Universität Mainz = Johannes Gutenberg University (JGU), Helsingin yliopisto = Helsingfors universitet = University of Helsinki-Helsingin yliopisto = Helsingfors universitet = University of Helsinki, Helsingin yliopisto = Helsingfors universitet = University of Helsinki, Amsterdam UMC - Amsterdam University Medical Center, Nanyang Technological University [Singapour], Universität zu Lübeck = University of Lübeck [Lübeck], Laboratoire d'Informatique Médicale et Ingénierie des Connaissances en e-Santé (LIMICS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Sorbonne Paris Nord, Université de Genève = University of Geneva (UNIGE), ANR-18-IBHU-0001,PreciDIAB,PreciDIAB Institute, the holistic approach of personal diabets care(2018), European Project: 633595,H2020,H2020-PHC-2014-two-stage,DYNAHEALTH(2015), European Project: 284167,EC:FP7:ERC,ERC-2011-StG_20101124,ADDICTION(2011), European Project: 692145,H2020,H2020-TWINN-2015,ePerMed(2016), Biological Psychology, APH - Health Behaviors & Chronic Diseases, APH - Personalized Medicine, Functional Genomics, APH - Mental Health, Sociology and Social Gerontology, APH - Methodology, Hottenga, Jouke- Jan [0000-0002-5668-2368], Bouatia-Naji, Nabila [0000-0001-5424-2134], Jansen, Rick [0000-0002-3333-6737], Min, Josine L. [0000-0003-4456-9824], Faggian, Alessia [0000-0002-3799-9722], Bonnefond, Amélie [0000-0001-9976-3005], Isaacs, Aaron [0000-0001-5037-4834], Willems, Sara M. [0000-0002-6803-3007], Navarro, Pau [0000-0001-5576-8584], Jackson, Anne U. [0000-0002-9672-2547], Bielak, Lawrence F. [0000-0002-3443-8030], Saxena, Richa [0000-0003-2233-1065], Smith, Albert V. [0000-0003-1942-5845], Verweij, Niek [0000-0002-4303-7685], Goel, Anuj [0000-0003-2307-4021], Johnson, Paul C. D. [0000-0001-6663-7520], Strawbridge, Rona J. [0000-0001-8506-3585], Fall, Tove [0000-0003-2071-5866], Fraser, Ross M. [0000-0003-0488-2592], Kanoni, Stavroula [0000-0002-1691-9615], Giedraitis, Vilmantas [0000-0003-3423-2021], Kleber, Marcus E. [0000-0003-0663-7275], Müller-Nurasyid, Martina [0000-0003-3793-5910], Luan, Jian’an [0000-0003-3137-6337], Sanna, Serena [0000-0002-3768-1749], Nolte, Ilja M. [0000-0001-5047-4077], Zemunik, Tatijana [0000-0001-8120-2891], Kovacs, Peter [0000-0002-0290-5423], Wild, Sarah H. [0000-0001-7824-2569], McLachlan, Stela [0000-0003-0480-6143], Egan, Josephine [0000-0002-8945-0053], Hicks, Andrew A. [0000-0001-6320-0411], Thorand, Barbara [0000-0002-8416-6440], Hingorani, Aroon [0000-0001-8365-0081], Kivimaki, Mika [0000-0002-4699-5627], Koistinen, Heikki A. [0000-0001-7870-070X], Bakker, Stephan J. L. [0000-0003-3356-6791], Palmer, Colin N. A. [0000-0002-6415-6560], Jukema, J. Wouter [0000-0002-3246-8359], Sattar, Naveed [0000-0002-1604-2593], Snieder, Harold [0000-0003-1949-2298], Magnusson, Patrik K. [0000-0002-7315-7899], Blüher, Matthias [0000-0003-0208-2065], Wolffenbuttel, Bruce H. R. [0000-0001-9262-6921], Abecasis, Goncalo R. [0000-0003-1509-1825], Meigs, James B. [0000-0002-2439-2657], Wilson, James F. [0000-0001-5751-9178], Schwarz, Peter E. H. [0000-0001-6317-7880], Boehm, Bernhard O. [0000-0002-2706-7710], Metspalu, Andres [0000-0002-3718-796X], Deloukas, Panos [0000-0001-9251-070X], Körner, Antje [0000-0001-6001-0356], Wareham, Nicholas J. [0000-0003-1422-2993], Langenberg, Claudia [0000-0002-5017-7344], Männistö, Satu [0000-0002-8668-3046], Franks, Paul W. [0000-0002-0520-7604], Hayward, Caroline [0000-0002-9405-9550], Vitart, Veronique [0000-0002-4991-3797], Kaprio, Jaakko [0000-0002-3716-2455], Visvikis-Siest, Sophie [0000-0001-8104-8425], Altshuler, David [0000-0002-7250-4107], Rudan, Igor [0000-0001-6993-6884], van Duijn, Cornelia M. [0000-0002-2374-9204], Pramstaller, Peter P. [0000-0002-9831-8302], Boehnke, Michael [0000-0002-6442-7754], Frayling, Timothy M. [0000-0001-8362-2603], Peyser, Patricia A. [0000-0002-9717-8459], Harst, Pim van der [0000-0002-2713-686X], Smith, George Davey [0000-0002-1407-8314], Forouhi, Nita G. [0000-0002-5041-248X], Loos, Ruth J. F. [0000-0002-8532-5087], Salomaa, Veikko [0000-0001-7563-5324], Soranzo, Nicole [0000-0003-1095-3852], Boomsma, Dorret I. [0000-0002-7099-7972], Groop, Leif [0000-0002-0187-3263], Tuomi, Tiinamaija [0000-0002-8306-6202], Munroe, Patricia B. [0000-0002-4176-2947], Gudnason, Vilmundur [0000-0001-5696-0084], Lecoeur, Cecile [0000-0003-0075-6417], Jarvelin, Marjo-Riitta [0000-0002-2149-0630], Stefansson, Kari [0000-0003-1676-864X], Dermitzakis, Emmanouil T. [0000-0002-9302-6490], Lindgren, Cecilia M. [0000-0002-4903-9374], Froguel, Philippe [0000-0003-2972-0784], Kaakinen, Marika A. [0000-0002-9228-0462], Watanabe, Richard M. [0000-0003-1015-0531], Ingelsson, Erik [0000-0003-2256-6972], Dupuis, Josée [0000-0003-2871-3603], Barroso, Inês [0000-0001-5800-4520], Apollo - University of Cambridge Repository, Epidemiology, University Hospital Mannheim | Universitätsmedizin Mannheim, National Research Council of Italy | Consiglio Nazionale delle Ricerche (CNR), Universität Leipzig, Universiteit Leiden, Universität Heidelberg [Heidelberg] = Heidelberg University, Karl-Franzens-Universität [Graz, Autriche], Psychiatry, Amsterdam Neuroscience - Complex Trait Genetics, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, General practice, APH - Digital Health, Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Life Course Epidemiology (LCE), Lifestyle Medicine (LM), Groningen Institute for Organ Transplantation (GIOT), Groningen Kidney Center (GKC), Center for Liver, Digestive and Metabolic Diseases (CLDM), Value, Affordability and Sustainability (VALUE), Cardiovascular Centre (CVC), Hottenga, Jouke-Jan [0000-0002-5668-2368], Min, Josine L [0000-0003-4456-9824], Willems, Sara M [0000-0002-6803-3007], Jackson, Anne U [0000-0002-9672-2547], Bielak, Lawrence F [0000-0002-3443-8030], Smith, Albert V [0000-0003-1942-5845], Johnson, Paul CD [0000-0001-6663-7520], Strawbridge, Rona J [0000-0001-8506-3585], Fraser, Ross M [0000-0003-0488-2592], Kleber, Marcus E [0000-0003-0663-7275], Luan, Jian'an [0000-0003-3137-6337], Nolte, Ilja M [0000-0001-5047-4077], Wild, Sarah H [0000-0001-7824-2569], Hicks, Andrew A [0000-0001-6320-0411], Koistinen, Heikki A [0000-0001-7870-070X], Bakker, Stephan JL [0000-0003-3356-6791], Palmer, Colin NA [0000-0002-6415-6560], Jukema, J Wouter [0000-0002-3246-8359], Magnusson, Patrik K [0000-0002-7315-7899], Wolffenbuttel, Bruce HR [0000-0001-9262-6921], Abecasis, Goncalo R [0000-0003-1509-1825], Meigs, James B [0000-0002-2439-2657], Wilson, James F [0000-0001-5751-9178], Schwarz, Peter EH [0000-0001-6317-7880], Boehm, Bernhard O [0000-0002-2706-7710], Wareham, Nicholas J [0000-0003-1422-2993], Franks, Paul W [0000-0002-0520-7604], van Duijn, Cornelia M [0000-0002-2374-9204], Pramstaller, Peter P [0000-0002-9831-8302], Frayling, Timothy M [0000-0001-8362-2603], Peyser, Patricia A [0000-0002-9717-8459], Forouhi, Nita G [0000-0002-5041-248X], Loos, Ruth JF [0000-0002-8532-5087], Boomsma, Dorret I [0000-0002-7099-7972], Munroe, Patricia B [0000-0002-4176-2947], Dermitzakis, Emmanouil T [0000-0002-9302-6490], Lindgren, Cecilia M [0000-0002-4903-9374], Kaakinen, Marika A [0000-0002-9228-0462], Watanabe, Richard M [0000-0003-1015-0531], Tampere University, Tays Research Services, Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC), Fysiologie, RS: FHML MaCSBio, and RS: Carim - B01 Blood proteins & engineering
Subjects: Male, Anorexia Nervosa, medicine.medical_treatment, 45/43, Insulin Resistance/genetics, SUSCEPTIBILITY, Quantitative trait, Impaired glucose tolerance, 0302 clinical medicine, Architecture, LS2_1, IMPUTATION, Insulin, ComputingMilieux_MISCELLANEOUS, Fasting, Publisher Correction, 3. Good health, [SDV] Life Sciences [q-bio], Kruppel-Like Transcription Factors/blood, Endokrinologi och diabetes, Science & Technology - Other Topics, Adult, Blood Glucose, European Continental Ancestry Group, Female, Gene Expression, Genetic Loci, Genome-Wide Association Study, Glucose Intolerance, Humans, Insulin Receptor Substrate Proteins, Insulin Resistance, Kruppel-Like Transcription Factors, Middle Aged, Phenotype, Sex Characteristics, Sex Factors, Waist-Hip Ratio, Sex characteristics, medicine.medical_specialty, Science, 631/208/205/2138, Endocrinology and Diabetes, General Biochemistry, Genetics and Molecular Biology, White People, Gender-differences, 03 medical and health sciences, SDG 3 - Good Health and Well-being, 692/53/2421, GLYCEMIC TRAITS, GENOME-WIDE ASSOCIATION, Glycemic, GENDER-DIFFERENCES, Science & Technology, IDENTIFICATION, 692/699/2743/2815, Blood Glucose/metabolism, Diagnostic markers, medicine.disease, Anorexia Nervosa/blood, 030104 developmental biology, Endocrinology, Glucose, Insulin/blood, Anorexia Nervosa/ethnology, Anorexia Nervosa/genetics, Anorexia Nervosa/physiopathology, Fasting/blood, Glucose Intolerance/blood, Glucose Intolerance/ethnology, Glucose Intolerance/genetics, Glucose Intolerance/physiopathology, Insulin Receptor Substrate Proteins/blood, Insulin Receptor Substrate Proteins/genetics, Kruppel-Like Transcription Factors/genetics, 0301 basic medicine, Identification, [SDV]Life Sciences [q-bio], General Physics and Astronomy, Genome-wide association studies, Waist–hip ratio, LS4_5, RISK, ARCHITECTURE, Multidisciplinary, article, Type 2 diabetes, Multidisciplinary Sciences, MENDELIAN RANDOMIZATION, Pre-diabetes, Medical Genetics, Risk, PATHOPHYSIOLOGY, 030209 endocrinology & metabolism, 3121 Internal medicine, 692/163/2743/137/773, NO, Insulin resistance, Internal medicine, Diabetes mellitus, medicine, Mendelian randomization, 631/208/480, Medicinsk genetik, business.industry, General Chemistry, Impaired fasting glucose, business
Abstract: Differences between sexes contribute to variation in the levels of fasting glucose and insulin. Epidemiological studies established a higher prevalence of impaired fasting glucose in men and impaired glucose tolerance in women, however, the genetic component underlying this phenomenon is not established. We assess sex-dimorphic (73,089/50,404 women and 67,506/47,806 men) and sex-combined (151,188/105,056 individuals) fasting glucose/fasting insulin genetic effects via genome-wide association study meta-analyses in individuals of European descent without diabetes. Here we report sex dimorphism in allelic effects on fasting insulin at IRS1 and ZNF12 loci, the latter showing higher RNA expression in whole blood in women compared to men. We also observe sex-homogeneous effects on fasting glucose at seven novel loci. Fasting insulin in women shows stronger genetic correlations than in men with waist-to-hip ratio and anorexia nervosa. Furthermore, waist-to-hip ratio is causally related to insulin resistance in women, but not in men. These results position dissection of metabolic and glycemic health sex dimorphism as a steppingstone for understanding differences in genetic effects between women and men in related phenotypes., Sex differences in fasting glucose and insulin have been identified, but the genetic loci underlying these differences have not. Here, the authors perform a meta-analysis of genome-wide association studies to detect sex-specific and sex-dimorphic loci associated with fasting glucose and insulin.
Published: 2021
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20. Controlled covalent functionalization of a graphene-channel of a field effect transistor as an ideal platform for (bio)sensing applications

Author: Sabine Szunerits, Johannes Bintinger, Rabah Boukherroub, Teresa Rodrigues, Vladyslav Mishyn, Henri Happy, Wolfgang Knoll, Christoph Kleber, Yann R. Leroux, Patrik Aspermair, Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Austrian Institute of Technology [Vienna] (AIT), Institut des Sciences Chimiques de Rennes (ISCR), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA), Carbon - IEMN (CARBON-IEMN), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Danube University Krems, NanoBioInterfaces - IEMN (NBI - IEMN), Financial support from the Centre National de la Recherche Scientifique (CNRS) and the University of Lille is acknowledged., Université catholique de Lille (UCL)-Université catholique de Lille (UCL), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Carbon - IEMN (CARBON - IEMN), Université catholique de Lille (UCL)-Université catholique de Lille (UCL)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Renatech Network, and PCMP PCP
Subjects: Materials science, Fabrication, Nanotechnology, 02 engineering and technology, 010402 general chemistry, Electrochemistry, 01 natural sciences, law.invention, chemistry.chemical_compound, [SPI]Engineering Sciences [physics], law, Monolayer, Molecule, [CHIM]Chemical Sciences, General Materials Science, Electrodes, Cycloaddition Reaction, Graphene, Aryl, 021001 nanoscience & nanotechnology, 0104 chemical sciences, chemistry, Electrode, Click Chemistry, Graphite, Field-effect transistor, Gold, 0210 nano-technology
Abstract: International audience; The controlled covalent functionalization of the graphene channel of a field effect transistor, based on interdigitated gold electrodes (source and drain), via electrochemical grafting, using specifically designed aryl diazonium species is demonstrated to allow the simple fabrication of a general platform for (bio)sensing applications. The electrochemical grafting of a protected ethynylphenyl diazonium salt leads to the deposition of only a monolayer on the graphene channel. This controlled covalent functionalization of the graphene channel results in a charge mobility of the GFET of 1739 ± 376 cm2 V−1 s−1 and 1698 ± 536 cm2 V−1 s−1 for the holes and electrons, respectively, allowing their utilization as (bio)sensors. After deprotection, a dense and compact ethynylphenyl monolayer is obtained and allows the immobilization of a wide range of (bio)molecules by a “click” chemistry coupling reaction (Huisgen 1,3-dipolar cycloaddition). This finding opens promising options for graphene-based (bio)sensing applications.
Published: 2021
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21. Alone but together: flow experience and its impact on creative output in LEGO® SERIOUS PLAY®

Author: Stephan Sonnenburg, Dirk J. Primus, Lukas Zenk, Danube University Krems, ICN Business School, Centre Européen de Recherche en Economie Financière et Gestion des Entreprises (CEREFIGE), and Université de Lorraine (UL)
Subjects: Experience sampling method, Autotelic, Process (engineering), media_common.quotation_subject, 05 social sciences, Applied psychology, 050109 social psychology, Context (language use), 16. Peace & justice, Serious play, [SHS]Humanities and Social Sciences, Management of Technology and Innovation, 0502 economics and business, Happiness, Research studies, 0501 psychology and cognitive sciences, Psychology, 050203 business & management, media_common
Abstract: PurposeDo LEGO® SERIOUS PLAY® (LSP) workshops result in improved experience of flow components as well as higher levels of creative output than traditional meetings (MEET)? This research studies the extent to which LSP, as a specialized material-mediated and process-oriented cocreative workshop setting, differs from MEET, a traditional workshop setting. Hypotheses for differences in individual flow components (autotelic behavior, happiness, balance), group flow components (equal participation, continuous communication) and creative output were developed and tested in a quasi-experimental comparison between LSP and MEET.Design/methodology/approachThe study was conducted with 39 practitioners in six teams from various industries. In total, 164 observations were collected during two workshops using the Experience Sampling Method. The creative output was assessed by peer evaluations of all participants, followed by structural analysis and quantitative group comparisons.FindingsThe results show that two components of individual flow experience (autotelic behavior, happiness) were significantly higher in LSP, and one of the components of group flow experience (continuous communication) was, as expected, significantly lower. Regarding creative output, the LSP teams outperformed the MEET teams. The study suggests that a process-oriented setting that includes time for individuals to independently explore their ideas using a different kind of material in the presence of other participants has a significant influence on the team result.Practical implicationsLSP can improve the components of participants' flow experience to have an impact on the creative output of teams. In cocreative settings like LSP, teams benefit from a combination of alone time and high-quality collaborative activities using boundary objects and a clear process to share their ideas.Originality/valueThis is the first quasi-experimental study with management practitioners as participants to compare LSP with a traditional and widespread workshop approach in the context of flow experience and creative output.
Published: 2021
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22. Digital verbunden Formen politischer Partizipation von Jugendlichen in Niederösterreich

Author: Ajanovi��, Edma, Fritsch, Katharina, Zahorka, Florian, Donau-Universität Krems (Danube University Krems), Centre Marc Bloch (CMB), and Ministère de l'Europe et des Affaires étrangères (MEAE)-Bundesministerium für Bildung und Forschung-Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.)-Centre National de la Recherche Scientifique (CNRS)
Subjects: [SHS.SCIPO]Humanities and Social Sciences/Political science
Abstract: Dieser Artikel analysiert vor dem Hintergrund post-fordistischer Transformationen und der wenigen Studien zu ��sterreich das Verh��ltnis digitaler Formen politischer Beteiligung und traditioneller Formen politischer und medialer Repr��sentationen von Jugendlichen. Unsere Fragestellung untersuchen wir aus frameanalytischer Perspektive und greifen auf Daten zur��ck, die wir im Zuge einer Medienanalyse und partizipativen Ethnografie rund um die Gemeinderatswahl 2020 in Nieder��sterreich erhoben haben. Wir er��rtern (Selbst-)Repr��sentationen und Formen der Partizipation von Jugendlichen entlang von drei Dimensionen: Jugend und Lokalpolitik, Jugend und Klima und Jugend als digitale Akteur*innen. Dabei zeigen wir, dass politische Praktiken von Jugendlichen vornehmlich von latenten Formen der Beteiligung �� offline und online �� gepr��gt sind und streichen die Rolle von Memes als digitale Praktik hervor. Unser Artikel leistet einen Beitrag zur Frage, wie ��ffentlichkeit im Zeitalter digitaler Plattformen entsteht und wie junge Menschen dazu beitragen. Dabei verweisen unsere Ergebnisse vor allem auf die viel besprochene Tendenz einer Individualisierung politischer Beteiligung im Kontext von Digitalisierung., Momentum Quarterly - Zeitschrift f��r sozialen Fortschritt, 10 (2), p. 66
Published: 2021
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23. Twins - A weak link in the magnetic hardening of ThMn12-type permanent magnets

Author: Dhanalakshmi Palanisamy, Iliya Radulov, Johann Fischbacher, Gabriel Gomez Eslava, Dierk Raabe, Baptiste Gault, Thibaut Devillers, Oliver Gutfleisch, Gino Hrkac, Konstantin P. Skokov, L.V.B. Diop, Lukas Schäfer, Semih Ener, Fernando Maccari, Thomas Schrefl, Nora M. Dempsey, Technische Universität Darmstadt (TU Darmstadt), Max-Planck-Institut für Eisenforschung GmbH, Max-Planck-Gesellschaft, Micro et NanoMagnétisme (MNM), Institut Néel (NEEL), Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Danube University Krems, Imperial College London, and University of Exeter
Subjects: Materials science, Polymers and Plastics, microstructure, Nucleation, 02 engineering and technology, Atom probe, 01 natural sciences, law.invention, law, 0103 physical sciences, coercivity, magnets, 010302 applied physics, Condensed matter physics, Metals and Alloys, ThMn12-type compounds, [CHIM.MATE]Chemical Sciences/Material chemistry, Coercivity, 021001 nanoscience & nanotechnology, Microstructure, Electronic, Optical and Magnetic Materials, Domain wall (magnetism), Remanence, Magnet, Ceramics and Composites, Hardening (metallurgy), [PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci], twin boundaries, 0210 nano-technology
Abstract: International audience; Nd2Fe14B-type materials exhibit the highest energy product around room temperature and hence dominate the high-performance permanent magnet market. Intensive research efforts aim at alternative material systems containing less critical elements with similar or better magnetic properties. Nd-and Sm-based compounds with a ThMn12-type structure exhibit intrinsic properties comparable or even superior to Nd2Fe14B. However, it has not been possible to achieve technically relevant coercivity and remanent magnetization in ThMn12-based bulk sintered magnets. Using SmFe11Ti as a prototypical representative, we demonstrate that one important reason for the poor performance is the formation of twins inside micro-crystalline grains. The nature of the twins in SmFe11Ti was investigated in twinned "single crystals" and both bulk and thin film poly-crystalline samples, using advanced electron microscopy and atom probe tomography as well as simulations and compared with benchmark Nd2Fe14B. Both micro-twins and nano-twins show a twin orientation of 57±2 • and an enrichment in Sm, which could affect domain wall motion in this 2 material. Micromagnetic simulations indicate that twins act as nucleation centers, representing the magnetically weakest link in the microstructure. The relation between twin formation energies and geometrical features are briefly discussed using molecular dynamic simulations.
Published: 2021
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24. Loss of Olfactory Function—Early Indicator for Covid-19, Other Viral Infections and Neurodegenerative Disorders

Author: Rebholz, Heike, Braun, Ralf, Ladage, Dennis, Knoll, Wolfgang, Kleber, Christoph, Hassel, Achim, Danube University Krems, GHU Paris Psychiatrie et Neurosciences, Institut de psychiatrie et neurosciences de Paris (IPNP - U1266 Inserm), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Universitätsklinikum Köln (Uniklinik Köln), Austrian Institute of Technology [Vienna] (AIT), Johannes Kepler University Linz [Linz] (JKU), This work was supported by the Lower Austrian ProvincialGovernment – Department K3 Science and Research., Martinez Rico, Clara, and Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)
Subjects: SARS–CoV-2, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, Neurology, hyposmia, COVID-19, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Review, normosmia, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, anosmia
Abstract: International audience; The loss of the senses of smell (anosmia) and taste (ageusia)are rather commondisorders, affecting up to 20% of the adult population. Yet,this condition has notreceived the attention it deserves, most probably because per se such a disorder isnot life threatening. However, loss of olfactory function significantly reduces the qualityof life of the affected patients, leading to dislike in food and insufficient, exaggeratedor unbalanced food intake, unintentional exposure to toxins such as household gas,social isolation, depression, and an overall insecurity. Not only is olfactory dysfunctionrather prevalent in the healthy population, it is, in many instances, also a correlate or anearly indicator of a panoply of diseases. Importantly, olfactory dysfunction is linked to thetwo most prominent neurodegenerative disorders, Parkinson’s disease and Alzheimer’sdisease. Anosmia and hyposmia (reduced sense of smell) affect a majority of patientsyears before the onset of cognitive or motor symptoms, establishing olfactory dysfunctionas early biomarker that can enable earlier diagnosis and preventative treatments. In thecurrent health crisis caused by SARS-CoV2, anosmia and dysgeusia as early-onsetsymptoms in virus-positive patients may prove to be highly relevant and crucial forpre-symptomatic Covid-19 detection from a public health perspective, preceding bydays the more classical respiratory tract symptoms such as cough, tightness of thechest or fever. Thus, the olfactory system seems to be at the frontline of pathologicassault, be it through pathogens or insults that can lead to or at least associatewith neurodegeneration. The aim of this review is to assemble current knowledgefrom different medical fields that all share a common denominator, olfactory/gustatorydysfunction, and to distill overarching etiologies and disease progression mechanisms.
Published: 2020
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25. Identification of Competencies and Teaching Models for the Governance of Smart Sustainable Cities in the South American Context

Author: Aurora Sánchez-Ortiz, Elsa Estevez, Gabriela Viale-Pereira, Mauricio Solar, Universidad Católica del Norte [Antofagasta], Universidad Tecnica Federico Santa Maria [Valparaiso] (UTFSM), Universidad Nacional del Sur [Argentina] (UNS), Danube University Krems, Gabriela Viale Pereira, Marijn Janssen, Habin Lee, Ida Lindgren, Manuel Pedro Rodríguez Bolívar, Hans Jochen Scholl, Anneke Zuiderwijk, TC 8, and WG 8.5
Subjects: 050101 languages & linguistics, [SHS.INFO]Humanities and Social Sciences/Library and information sciences, Context (language use), 02 engineering and technology, Political science, 11. Sustainability, 0202 electrical engineering, electronic engineering, information engineering, 0501 psychology and cognitive sciences, [INFO]Computer Science [cs], Erasmus+, Sustainable cities, Government, Governance, business.industry, Instructional design, 4. Education, Corporate governance, 05 social sciences, Human-capacity, Public relations, South America, Identification (information), Sustainable city, South american, 020201 artificial intelligence & image processing, business, Smart cities
Abstract: Part 5: Smart Cities; International audience; This study is developed in the context of the Strengthening Governance Capacity for Smart Sustainable Cities (CAP4CITY) Project, part of the Erasmus + Programme. The study aims to support the design of teaching materials to address the human-capacity related needs for the governance of Smart Sustainable Cities (SSC) in South America. This article identifies the competencies and instructional design for the design of smart sustainable cities courses adapted to the South American context. Applying a scenario-building approach and the CAP4CITY roadmap for smart sustainable city initiatives, we conducted two workshops in Chile and two in Argentina attended by representatives from academia, NGOs, government agencies, and private companies. Using the data about competencies and teaching models gathered during these events, the study clustered the data and identified the major areas of competences and instructional methods. Lastly, we compared the results from both countries.
Published: 2020
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26. Analysing Legal Information Requirements for Public Policy Making

Author: Charalampos Alexopoulos, Shefali Virkar, Anna-Sophie Novak, Euripidis N. Loukis, Michalis Avgerinos Loutsaris, University of the Aegean, Danube University Krems, Sara Hofmann, Csaba Csáki, Noella Edelmann, Thomas Lampoltshammer, Ulf Melin, Peter Parycek, Gerhard Schwabe, Efthimios Tambouris, TC 8, and WG 8.5
Subjects: Legal informatics, Decision support system, Knowledge management, business.industry, Public policy, [SHS.INFO]Humanities and Social Sciences/Library and information sciences, 05 social sciences, Information needs, ComputingMilieux_LEGALASPECTSOFCOMPUTING, 02 engineering and technology, Decision support systems, Legal information, Order (exchange), Analytics, 0202 electrical engineering, electronic engineering, information engineering, Information system, 020201 artificial intelligence & image processing, [INFO]Computer Science [cs], Service provision, 0509 other social sciences, 050904 information & library sciences, business, Set (psychology)
Abstract: Part 4: User Perspectives; International audience; Most of the research that has been conducted in the area of legal informatics concerns its ‘supply side’, dealing with the development of effective systems for legal information provision. However, limited research has been conducted on the ‘demand side’ of legal information provision, though it is absolutely necessary to gain a good understanding of it, in order to design effective and useful systems for the provision of legal information; furthermore, this limited research is dealing with the legal information needs of the lawyers, and neglects the ones of other important groups. This paper contributes to filling this research gap. It analyses legal information requirements of a highly important for the society group: the designers of public policies. Initially we investigate current legal information sources and systems used by public policy makers, as well as their relevant search practices. Then we investigate their business needs for additional capabilities/functionalities for a better support of their policymaking activities using advanced legal analytics tools and services. Finally, we discuss the information, processing and technical requirements for the development of a legal information system providing the above advanced functionalities and services. For the above purposes, we have collected data through semi-structured interviews form 13 Greek and 7 Austrian public administrators dealing with the design of public policies, which lead to interesting and useful insights, as well as a novel set of additional advanced capabilities and functionalities that can give rise to a new generation of legal informatics.
Published: 2020
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27. Digital Transformation in the Context of the Open Government Partnership

Author: Noella Edelmann, Mary Francoli, Danube University Krems, Carleton University, Sara Hofmann, Csaba Csáki, Noella Edelmann, Thomas Lampoltshammer, Ulf Melin, Peter Parycek, Gerhard Schwabe, Efthimios Tambouris, TC 8, and WG 8.5
Subjects: Open government, Government, business.industry, Corporate governance, [SHS.INFO]Humanities and Social Sciences/Library and information sciences, 05 social sciences, Digital transformation, Context (language use), Public relations, 16. Peace & justice, 0506 political science, Action (philosophy), Open Government Partnership, General partnership, Qualitative research, 050602 political science & public administration, [INFO]Computer Science [cs], 0509 other social sciences, 050904 information & library sciences, business
Abstract: Part 3: Open Government and Transparency; International audience; This paper explores the connection between membership in the Open Government Partnership (OGP) and digital transformation. It employs a qualitative research approach and document analysis to examine OGP Independent Reporting Mechanism (IRM) Reports and government self-assessment reports, to get a sense of the nature of digital transformation commitments made within OGP national action plans. This includes a look at what the commitments are, why they are made, and their results. Ultimately, it is found that while few OGP members focus on achieving digital transformation results, most are not leveraging their membership to advance digital transformation. Moreover, those that do are not doing so in a way that addresses a clear policy or governance issue, rendering it difficult to comment on whether the commitments are effectively advancing open government. The mandatory assessment of OGP action plans helps, to some degree, to drive members to complete their commitments, and serves as a useful tool for advancing policies as they relate to open government.
Published: 2020
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28. Electronic Participation: 12th IFIP WG 8.5 International Conference, ePart 2020, Linköping, Sweden, August 31 – September 2, 2020, Proceedings

Author: Hofmann, Sara, Csáki, Csaba, Edelmann, Noella, Lampoltshammer, Thomas, Melin, Ulf, Parycek, Peter, Schwabe, Gerhard, Tambouris, Efthimios, University of Agder (UIA), Corvinus University of Budapest, Danube University Krems, Linköping University (LIU), Universität Zürich [Zürich] = University of Zurich (UZH), University of Macedonia [Thessaloniki] (UoM), TC 8, and WG 8.5
Subjects: [INFO]Computer Science [cs]
Abstract: International audience; Book Front Matter of LNCS 12220
Published: 2020
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29. The worldwide clinical trial research response to the COVID-19 pandemic - the first 100 days

Author: Perrine Janiaud, Cathrine Axfors, Janneke van't Hooft, Ramon Saccilotto, Arnav Agarwal, Christian Appenzeller-Herzog, Despina G. Contopoulos-Ioannidis, Valentin Danchev, Ulrich Dirnagl, Hannah Ewald, Gerald Gartlehner, Steven N. Goodman, Noah A. Haber, Angeliki Diotima Ioannidis, John P. A. Ioannidis, Mark P. Lythgoe, Wenyan Ma, Malcolm Macleod, Mario Malički, Joerg J. Meerpohl, Yan Min, David Moher, Blin Nagavci, Florian Naudet, Christiane Pauli-Magnus, Jack W. O'Sullivan, Nico Riedel, Jan A. Roth, Mandy Sauermann, Stefan Schandelmaier, Andreas M. Schmitt, Benjamin Speich, Paula R. Williamson, Lars G. Hemkens, HAL UR1, Admin, University of Basel (Unibas), Meta-Research Innovation Center at Stanford (METRICS), Stanford School of Medicine [Stanford], Stanford Medicine, Stanford University-Stanford University-Stanford Medicine, Stanford University-Stanford University, Stanford University, Uppsala University, Universiteit van Amsterdam (UvA), University of Toronto, Stanford University School of Medicine [CA, USA], Berlin Institute of Health (BIH), Danube University Krems, University of California [Los Angeles] (UCLA), University of California (UC), Imperial College London, University of Edinburgh, University of Freiburg [Freiburg], Ottawa Hospital Research Institute [Ottawa] (OHRI), Centre d'Investigation Clinique [Rennes] (CIC), Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Pontchaillou [Rennes], University Hospital Basel [Basel], McMaster University [Hamilton, Ontario], University of Oxford, University of Liverpool, Laura and John Arnold Foundation, 31CA30_196190, Schweizerischer Nationalfonds zur F&#x00F6, rderung der Wissenschaftlichen Forschung, Obstetrics and Gynaecology, University of California, Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), and University of Oxford [Oxford]
Subjects: 0301 basic medicine, China, clinical research agenda, hydroxychloroquine, Pneumonia, Viral, 0601 Biochemistry and Cell Biology, General Biochemistry, Genetics and Molecular Biology, Betacoronavirus, 03 medical and health sciences, 0302 clinical medicine, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Humans, 1112 Oncology and Carcinogenesis, 030212 general & internal medicine, General Pharmacology, Toxicology and Pharmaceutics, Pandemics, [SDV.MHEP.ME] Life Sciences [q-bio]/Human health and pathology/Emerging diseases, Clinical Trials as Topic, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, General Immunology and Microbiology, SARS-CoV-2, covid 19, COVID-19, 1103 Clinical Sciences, Articles, General Medicine, 16. Peace & justice, 3. Good health, 030104 developmental biology, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.SP.PHARMA] Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Health Services Research, Coronavirus Infections, Research Article
Abstract: Background: Never before have clinical trials drawn as much public attention as those testing interventions for COVID-19. We aimed to describe the worldwide COVID-19 clinical research response and its evolution over the first 100 days of the pandemic. Methods: Descriptive analysis of planned, ongoing or completed trials by April 9, 2020 testing any intervention to treat or prevent COVID-19, systematically identified in trial registries, preprint servers, and literature databases. A survey was conducted of all trials to assess their recruitment status up to July 6, 2020. Results: Most of the 689 trials (overall target sample size 396,366) were small (median sample size 120; interquartile range [IQR] 60-300) but randomized (75.8%; n=522) and were often conducted in China (51.1%; n=352) or the USA (11%; n=76). 525 trials (76.2%) planned to include 155,571 hospitalized patients, and 25 (3.6%) planned to include 96,821 health-care workers. Treatments were evaluated in 607 trials (88.1%), frequently antivirals (n=144) or antimalarials (n=112); 78 trials (11.3%) focused on prevention, including 14 vaccine trials. No trial investigated social distancing. Interventions tested in 11 trials with >5,000 participants were also tested in 169 smaller trials (median sample size 273; IQR 90-700). Hydroxychloroquine alone was investigated in 110 trials. While 414 trials (60.0%) expected completion in 2020, only 35 trials (4.1%; 3,071 participants) were completed by July 6. Of 112 trials with detailed recruitment information, 55 had recruited Conclusions: The size and speed of the COVID-19 clinical trials agenda is unprecedented. However, most trials were small investigating a small fraction of treatment options. The feasibility of this research agenda is questionable, and many trials may end in futility, wasting research resources. Much better coordination is needed to respond to global health threats.
Published: 2020
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30. Electronic Government: 19th IFIP WG 8.5 International Conference, EGOV 2020, Linköping, Sweden, August 31 – September 2, 2020, Proceedings

Author: Viale Pereira, Gabriela, Janssen, Marijn, Lee, Habin, Lindgren, Ida, Rodríguez Bolívar, Manuel Pedro, Scholl, Hans Jochen, Zuiderwijk, Anneke, Danube University Krems, Delft University of Technology (TU Delft), Brunel University London [Uxbridge], Linköping University (LIU), University of Granada [Granada], University of Washington [Seattle], TC 8, and WG 8.5
Subjects: [INFO]Computer Science [cs]
Abstract: International audience; Book Front Matter of LNCS 12219
Published: 2020
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31. Acceptance of Tools for Electronic Citizen Participation

Author: Michael Sachs, Judith Schossböck, Danube University Krems, City University of Hong Kong [Hong Kong] (CUHK), Panos Panagiotopoulos, Noella Edelmann, Olivier Glassey, Gianluca Misuraca, Peter Parycek, Thomas Lampoltshammer, Barbara Re, TC 8, and WG 8.5
Subjects: 050101 languages & linguistics, E-Participation, Identification, e-participation, Computer science, business.industry, Corporate governance, [SHS.INFO]Humanities and Social Sciences/Library and information sciences, 05 social sciences, Usability, Context (language use), 02 engineering and technology, Viewpoints, Trust, Data science, Identification (information), Order (business), 0202 electrical engineering, electronic engineering, information engineering, Key (cryptography), 020201 artificial intelligence & image processing, 0501 psychology and cognitive sciences, [INFO]Computer Science [cs], business, Decision-making
Abstract: Part 1: eParticipation Developments; International audience; In order to motivate diverse user groups to participate in e-participation, platform designers are keen to offer attractive communication formats in combination with modern tools and suitable forms of online identification. This does not come without difficulties, as individual users prefer different solutions. Research on tools and electronic identification in this context has investigated the appropriateness of different e-IDs for different stages of e-participation. In this respect, this paper offers three contributions to questions of technology application and acceptance in e-participation: Firstly, it showcases two scenarios from a platform simulation on different levels of e-participation. Secondly, the authors present results on the acceptance of these scenarios and tools based on questionnaires and usability tests. Thirdly, viewpoints from interviews with key stakeholders for e-participation in governance and politics are included. Results shall be useful for the future design and implementation of e-participation platforms.
Published: 2019
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32. Using Disruptive Technologies in Government: Identification of Research and Training Needs

Author: Alexander Ronzhyn, Charalampos Alexopoulos, Maria A. Wimmer, Gabriela Viale Pereira, Vera Spitzer, Universität Koblenz-Landau [Koblenz], Danube University Krems, Department of Information & Communication Systems Engineering [Grece], University of the Aegean, Ida Lindgren, Marijn Janssen, Habin Lee, Andrea Polini, Manuel Pedro Rodríguez Bolívar, Hans Jochen Scholl, Efthimios Tambouris, TC 8, and WG 8.5
Subjects: 050101 languages & linguistics, Government, Knowledge management, Point (typography), business.industry, Emerging technologies, [SHS.INFO]Humanities and Social Sciences/Library and information sciences, 05 social sciences, Public sector, Big data, Digital government, Training needs, 02 engineering and technology, Scenario-technique, Disruptive technologies, Identification (information), 0202 electrical engineering, electronic engineering, information engineering, 020201 artificial intelligence & image processing, 0501 psychology and cognitive sciences, Augmented reality, Research needs, [INFO]Computer Science [cs], business
Abstract: Part 4: AI, Data Analytics and Automated Decision Making; International audience; Over the past years, a number of new technologies have emerged with a potential to disrupt many spheres of the society. While public sector traditionally lacks behind business in innovation, significant changes are anticipated with the use of disruptive technologies. The implementation of the new technologies for the government service provision, along with possible benefits, need to be well thought through and challenges need to be carefully discussed, analysed and evaluated. This paper uses scenario-technique to identify research and training needs for the implementation of disruptive technologies in government services. Using the input of 58 experts from three workshops, research and training needs for the internet of things, artificial intelligence, virtual and augmented reality, as well as big data technologies have been identified. The identified needs can serve as a starting point for a broader and more informed discussion about the knowledge and skills that the researchers and practitioners of digital government need to obtain for the broad use of such new (disruptive) technologies.
Published: 2019
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33. The Role of eParticipation in the Expansion of Individual Capabilities

Author: Fernando Bichara Pinto, Gabriela Viale Pereira, Marie Anne Macadar, Universidade Federal do Rio de Janeiro (UFRJ), Danube University Krems, Panos Panagiotopoulos, Noella Edelmann, Olivier Glassey, Gianluca Misuraca, Peter Parycek, Thomas Lampoltshammer, Barbara Re, TC 8, and WG 8.5
Subjects: 050101 languages & linguistics, Knowledge management, Operationalization, business.industry, Mechanism (biology), [SHS.INFO]Humanities and Social Sciences/Library and information sciences, 05 social sciences, Citizen journalism, Context (language use), 02 engineering and technology, Capability Approach (CA), Information and Communication Technology for Development (ICT4D), Political science, eParticipation, 0202 electrical engineering, electronic engineering, information engineering, Capability approach, 020201 artificial intelligence & image processing, 0501 psychology and cognitive sciences, [INFO]Computer Science [cs], business, Digital divide
Abstract: Part 4: User Perspectives; International audience; This article seeks to understand how eParticipation can boost individual capabilities in an ICT4D context. The analysis has regard eParticipation as a mechanism for expanding capabilities since it increases the democratic and participatory involvement of individuals in society. To this end, we examined the eParticipation field according to Sæbø et al. [18] and Medaglia [11], combining the capability approach from Sen’s [21] and Nussbaum’s [15] perspectives. Although the literature recognized that the capability approach is particularly difficult to operationalize in practice, we discovered some mechanisms in the eParticipation literature to support our analysis. However, despite its apparent benefits, eParticipation can indirectly contribute toward increasing inequalities among people since it is not available to all. We believe that recognition of the inequalities generated by the digital divide and the subsequent decrease in eParticipation could lead to a better understanding of the ICT4D context and assist in public policy-making.
Published: 2019
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34. An Agent-Based Framework for Complex Networks

Author: Maximilian Götzinger, Thilo Sauter, Alexander Wendt, Vienna University of Technology (TU Wien), University of Turku, Danube University Krems, John MacIntyre, Ilias Maglogiannis, Lazaros Iliadis, Elias Pimenidis, TC 12, and WG 12.5
Subjects: Industry 4.0, Self-adaption, Computer science, Distributed computing, Interoperability, Internet of Things, 02 engineering and technology, computer.software_genre, 01 natural sciences, Domain (software engineering), ACONA, 0202 electrical engineering, electronic engineering, information engineering, [INFO]Computer Science [cs], MQTT, Distributed application platform, Middleware, Multi-agent system, Communication, 010401 analytical chemistry, 020207 software engineering, Cognitive architecture, Complex network, 0104 chemical sciences, Middleware (distributed applications), computer, Evolutionary programming
Abstract: Part 11: Multi Agent - IoT; International audience; A large number of research and industrial projects could benefit from a module-based development. However, these modules and the communication between them may vary from project to project. Therefore, a general middleware instead of several specialized middlewares for each domain is desired. This paper presents the ACONA Framework (Agent-based Complex Network Architecture). It is an agent-based middleware with a lightweight and flexible infrastructure. Also, it offers the possibility of evolutionary programming. Its performance is demonstrated in three applications: (i) A cognitive architecture with around 40 interconnected modules; (ii) a stock market simulator with elements of evolutionary programming; and (iii) an industry 4.0 application of a conveyor belt.
Published: 2019
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35. Editorial: Towards an Understanding of Tinnitus Heterogeneity

Author: Christopher R. Cederroth, Silvano Gallus, Deborah A. Hall, Tobias Kleinjung, Berthold Langguth, Antonello Maruotti, Martin Meyer, Arnaud Norena, Thomas Probst, Rüdiger Pryss, Grant Searchfield, Giriraj Shekhawat, Myra Spiliopoulou, Sven Vanneste, Winfried Schlee, Karolinska Institutet [Stockholm], Istituto di Ricerche Farmacologiche 'Mario Negri', 20156 Milan, University of Nottingham, UK (UON), Universität Zürich [Zürich] = University of Zurich (UZH), University of Regensburg, University of Southampton, SPRU, Neurosciences sensorielles et cognitives (NSC), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Danube University Krems, Universität Ulm - Ulm University [Ulm, Allemagne], University of Auckland [Auckland], Auckland University of Technology (AUT), Otto-von-Guericke-Universität Magdeburg = Otto-von-Guericke University [Magdeburg] (OVGU), Brain Research centre Antwerp for Innovative and Interdisciplinary Neuromodulation (BRAI²N), Antwerp University Hospital [Edegem] (UZA), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Otto-von-Guericke University [Magdeburg] (OVGU), University of Zurich, and Cederroth, Christopher R
Subjects: 2805 Cognitive Neuroscience, Aging, Cognitive Neuroscience, 610 Medicine & health, 10045 Clinic for Otorhinolaryngology, Cognitive neuroscience, lcsh:RC321-571, neuroscience, 03 medical and health sciences, 0302 clinical medicine, Animal model, 1302 Aging, Medicine, tinnitus, 030223 otorhinolaryngology, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, ComputingMilieux_MISCELLANEOUS, business.industry, 10093 Institute of Psychology, [SCCO.NEUR]Cognitive science/Neuroscience, animal model, Ageing, Editorial, hearing, medicine.symptom, heterogeneity, genetic, business, Neuroscience, 030217 neurology & neurosurgery, Tinnitus
Abstract: International audience
Published: 2019
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36. Inter-governmental Collaborative Networks for Digital Government Innovation Transfer – Structure, Membership, Operations

Author: Tomasz Janowski, Magdalena Ciesielska, Gdańsk University of Technology (GUT), Danube University Krems, Luis M. Camarinha-Matos, Hamideh Afsarmanesh, and Dario Antonelli
Subjects: Structure (mathematical logic), Government, Knowledge management, Process (engineering), business.industry, 05 social sciences, Digital government, Collaborative networks, 0506 political science, Knowledge sharing, Innovation transfer, Transfer (computing), 050602 political science & public administration, Key (cryptography), [INFO]Computer Science [cs], Business, 0509 other social sciences, 050904 information & library sciences, Adaptation (computer science)
Abstract: Part 8: Collaborative Government and Social Policies; International audience; Digital government refers to the transformation of government organizations and their relationships with citizens, business and each other through digital technology. It entails digital innovation in processes, services, organizations, policies, etc. which are increasingly developed and tested in one country and transferred, after adaptation, to other countries. The process of innovation transfer and the underlying information and knowledge sharing increasing take place through networks. The aim of this study is to identify various forms of such networks, their structures, membership criteria and modes of operation. The study relies on the analysis of literature on innovation transfer, collaborative networks and inter-governmental collaboration, and a survey of existing inter-governmental networks for digital government innovation transfer. The key finding is that such networks are a growing form of international collaboration and an instrument in global economy.
Published: 2019
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37. Investigating the Social, Political, Economic and Cultural Implications of Data Trading

Author: Michela Vignoli, Shefali Virkar, Gabriela Viale Pereira, Danube University Krems, Austrian Institute of Technology [Vienna] (AIT), Ida Lindgren, Marijn Janssen, Habin Lee, Andrea Polini, Manuel Pedro Rodríguez Bolívar, Hans Jochen Scholl, Efthimios Tambouris, TC 8, and WG 8.5
Subjects: 050101 languages & linguistics, Empirical data, Leverage (finance), Public economics, [SHS.INFO]Humanities and Social Sciences/Library and information sciences, Data market, 05 social sciences, 02 engineering and technology, Social and cultural aspects, Open data, Politics, Data trading, Monetary value, 0202 electrical engineering, electronic engineering, information engineering, [INFO]Computer Science [cs], 020201 artificial intelligence & image processing, 0501 psychology and cognitive sciences, Business
Abstract: Part 3: Open Data: Social and Technical Aspects; International audience; Data market initiatives have, by assigning monetary value to data, and connecting the various actors responsible for its efficient production and consumption, far reaching consequences for national economies. The Data Market Austria (DMA) project represents a unique opportunity for Austria to leverage the enormous potential socio-economic benefits accruing from increased trade of data. At the same time, however, a number of key challenges to the successful uptake of the project needs to be considered, and new problems emerging from this new form of digital commercial infrastructure need to be anticipated and addressed. This study aims to examine how the benefits accruing to increased participation in a data-driven ecosystem can be applied to tackle the long-standing socio-cultural challenges and the possible societal and cultural impediments to the successful unfolding out of a data market. Theoretical discussions framed from arguments obtained through a systematic review of academic and scholarly literature are juxtaposed with empirical data obtained from data science experts and DMA project personnel to test whether they stand up to real-world practicalities and to narrow the focus onto the Austria-specific context. Our findings reveal that data is a dual-purpose commodity that has both commercial value and social application. To amplify the benefits accruing from increased data trading, it is vital that a country establishes a sound open data strategy and a balanced regulatory framework for data trading.
Published: 2019
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38. Digital Transformation in Public Sector Organisations: The Role of Informal Knowledge Sharing Networks and Social Media

Author: Gerald Steiner, Lukas Zenk, Nicole Hynek, Noella Edelmann, Peter Parycek, Shefali Virkar, Danube University Krems, Panos Panagiotopoulos, Noella Edelmann, Olivier Glassey, Gianluca Misuraca, Peter Parycek, Thomas Lampoltshammer, Barbara Re, TC 8, and WG 8.5
Subjects: 050101 languages & linguistics, Expediting, business.industry, [SHS.INFO]Humanities and Social Sciences/Library and information sciences, 05 social sciences, Public sector, Digital transformation, Organizational culture, 02 engineering and technology, Public relations, Informal knowledge sharing, Knowledge sharing, Social media, Empirical research, Order (exchange), 0202 electrical engineering, electronic engineering, information engineering, [INFO]Computer Science [cs], 020201 artificial intelligence & image processing, 0501 psychology and cognitive sciences, business
Abstract: Part 2: Digital Transformations; International audience; It is estimated that during the period 2020–2025, about 30% of the employees at the Austrian Ministry of Defence will retire. This raises the question of how to encourage employees to share informal knowledge in order to successfully embrace organisational change in increasingly digitised environments with a view to retaining them long-term. Through the development of a three-part empirical study, this research paper investigates the role played by informal knowledge sharing networks and social media in expediting digital transformation within a public sector organisation. Our findings show that the public sector stands to benefit from informal knowledge sharing, and that both a permissive organisational culture and the provision of clearly demarcated ‘knowledge sharing spaces’ are fundamental in this respect.
Published: 2019
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39. Literatura, exposiciones y comunicación: une conversación

Author: Johan Schimanski, Ulrike Spring, Heike Gfrereis, Helmut Neundlinger, Universität Stuttgart [Stuttgart], Danube University Krems, and University of Oslo (UiO)
Subjects: museos literarios, maisons d’écrivains, literary exhibitions, exposiciones literarias, Auden (W. H.), [SHS.INFO]Humanities and Social Sciences/Library and information sciences, media_common.quotation_subject, pratiques d’exposition, museos de autores, Art, prácticas expositivas, expositions littéraires, [SHS.MUSEO]Humanities and Social Sciences/Cultural heritage and museology, casas de escritores, musées littéraires, Visual arts, Exhibition, writers’ houses, exhibition practices, musées d’auteurs, literary museums, Conversation, author museums, media_common
Abstract: International audience; Informed by her competence in literature and the theory and practice of exhibitions, Heike Gfrereis is Head of the Museum Department at the Archive of German Literature in Marbach, and curator of many literary exhibitions. Helmut Neundlinger, curator of the W. H. Auden Memorial Museum in Kirchstetten, is a writer, researcher and critic working at the Center for Museum Collections Management at the Danube University Krems and the literary collection of Lower Austria. The following “exchange of knowledge” between them and two researchers in the TRAUM project –Transforming Author Museums– took place in Oslo in 2019. We discuss the desire to exhibit literature and not only biography, how one can free oneself from objects, how to unlearn received notions of literature, the importance of interaction and play, what can make authors difficult to exhibit, and the economic realities of exhibiting literature.; Gracias a sus conocimientos de literatura y de teoría y práctica de las exposiciones, Heike Gfrereis es directora del Departamento de Museos del Archivo de Literatura Alemana de Marbach y comisaria de numerosas exposiciones literarias. Helmut Neundlinger, conservador del Museo Conmemorativo de W. H. Auden en Kirchstetten, es escritor, investigador y crítico y trabaja en el Centro de Gestión de Colecciones de Museos de la Universidad del Danubio de Krems y en la colección literaria de la Baja Austria. El siguiente “intercambio de conocimientos” entre ellos y dos investigadores del proyecto TRAUM –Transforming Author Museums– tuvo lugar en Oslo en 2019. Hablamos del deseo de exponer literatura y no solo biografía, de cómo uno puede liberarse de los objetos , de cómo desaprender las nociones recibidas de la literatura, de la importancia de la interacción y el juego, de lo que puede hacer que los autores sean difíciles de exponer y de las realidades económicas de la exposición de la literatura.; Forte de ses compétences en littérature et en théorie et pratique des expositions, Heike Gfrereis est cheffe du département des musées aux Archives de la littérature allemande, à Marbach, et commissaire de nombreuses expositions littéraires. Helmut Neundlinger, conservateur du musée W. H. Auden à Kirchstetten, est un écrivain, chercheur et critique qui travaille au Centre de gestion des collections de musées de l’Université du Danube à Krems, et à la collection littéraire de Basse-Autriche. Leur échange avec deux chercheurs du projet Traum (Transformer les musées d’auteurs) a eu lieu à Oslo en 2019. Nous discutons du désir d’exposer la littérature, de la manière dont on peut se libérer des objets de la manière de désapprendre les notions reçues de la littérature, de l’importance de l’interaction et du jeu, de ce qui peut rendre les auteurs difficiles à exposer et des réalités économiques de l’exposition de la littérature.
Published: 2020
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40. Exploring Open Data State-of-the-Art: A Review of the Social, Economic and Political Impacts

Author: Shefali Virkar, Gabriela Viale Pereira, Danube University Krems, Peter Parycek, Olivier Glassey, Marijn Janssen, Hans Jochen Scholl, Efthimios Tambouris, Evangelos Kalampokis, Shefali Virkar, TC 8, and WG 8.5
Subjects: Public economics, Systematic survey, business.industry, [SHS.INFO]Humanities and Social Sciences/Library and information sciences, Corporate governance, media_common.quotation_subject, Open data, 05 social sciences, Public sector, effects of open data, 02 engineering and technology, Good governance, Politics, Intrinsic value (finance), State (polity), open government data, 020204 information systems, Political science, 0202 electrical engineering, electronic engineering, information engineering, [INFO]Computer Science [cs], 0509 other social sciences, 050904 information & library sciences, business, media_common
Abstract: Part 2: Open Data, Linked Data, and Semantic Web; International audience; This research paper explores the impact that the access to, and free usage of, stored (mainly public sector) data has on society, the economy and on good governance, together with the implications of this new paradigm for modern-day governments. Although a number of recent research studies attempt to identify the benefits and drawbacks of open data, or to demonstrate its role in governance processes, there exists to-date no systematic attempt to both rigorously survey current literature to enumerate the areas in which open data has had an impact and to discuss its potential as a significant tool for policymaking. To address this research gap, and to highlight its intrinsic value to different actors, we examine the current state-of-the-art on the impacts of open data research and practice through a systematic survey of extant scholarly and practitioner literature. The first part of our study will present a comprehensive overview of the societal, economic, and political impacts of open data. We will then evaluate the new possibilities afforded by open data to policymaking, and conclude with a discussion of its role in open governance.
Published: 2018
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41. Electronic Participation: 10th IFIP WG 8.5 International Conference, ePart 2018, Krems, Austria, September 3-5, 2018, Proceedings

Author: Edelmann, Noella, Parycek, Peter, Misuraca, Gianluca, Panagiotopoulos, Panos, Charalabidis, Yannis, Virkar, Shefali, Danube University Krems, European Commission - Joint Research Centre [Seville] (JRC), Queen Mary University of London (QMUL), University of the Aegean, TC 8, and WG 8.5
Subjects: [INFO]Computer Science [cs]
Abstract: International audience; Book Front Matter of LNCS 11021
Published: 2018
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42. Electronic Government: 17th IFIP WG 8.5 International Conference, EGOV 2018, Krems, Austria, September 3-5, 2018, Proceedings

Author: Parycek, Peter, Glassey, Olivier, Janssen, Marijn, Scholl, Hans Jochen, Tambouris, Efthimios, Kalampokis, Evangelos, Virkar, Shefali, Danube University Krems, Université de Lausanne (UNIL), Delft University of Technology (TU Delft), University of Washington [Seattle], University of Macedonia [Thessaloniki] (UoM), TC 8, and WG 8.5
Subjects: [INFO]Computer Science [cs]
Abstract: International audience; Book Front Matter of LNCS 11020
Published: 2018
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43. Strategies for Big Data Analytics through Lambda Architectures in Volatile Environments

Author: da Silva Veith, Alexandre, C. S. dos Anjos, Julio, Pignaton De Freitas, Edison, Lampoltshammer, Thomas, Geyer, Claudio, Algorithms and Software Architectures for Distributed and HPC Platforms (AVALON), Inria Grenoble - Rhône-Alpes, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Laboratoire de l'Informatique du Parallélisme (LIP), Centre National de la Recherche Scientifique (CNRS)-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-École normale supérieure - Lyon (ENS Lyon)-Centre National de la Recherche Scientifique (CNRS)-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-École normale supérieure - Lyon (ENS Lyon), Instituto de Informática da UFRGS (UFRGS), Universidade Federal do Rio Grande do Sul [Porto Alegre] (UFRGS), Danube University Krems, Instituto de Informática, Programa de Pós-Graduação em Computação [Porto Alegre] (PPGC), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)
Subjects: Performance (cs.PF), FOS: Computer and information sciences, [INFO.INFO-PF]Computer Science [cs]/Performance [cs.PF], Computer Science - Performance, Computer Science - Distributed, Parallel, and Cluster Computing, Distributed, Parallel, and Cluster Computing (cs.DC), [INFO.INFO-DC]Computer Science [cs]/Distributed, Parallel, and Cluster Computing [cs.DC]
Abstract: International audience; Expectations regarding the future growth of Internet of Things (IoT)-related technologies are high. These expectations require the realization of a sustainable general purpose application framework that is capable to handle these kinds of environments with their complexity in terms of heterogeneity and volatility. The paradigm of the Lambda architecture features key characteristics (such as robustness, fault tolerance, scalability, generalization, extensibility, ad-hoc queries, minimal maintenance, and low-latency reads and updates) to cope with this complexity. The paper at hand suggest a basic set of strategies to handle the arising challenges regarding the volatility, heterogeneity, and desired low latency execution by reducing the overall system timing (scheduling, execution, monitoring, and faults recovery) as well as possible faults (churn, no answers to executions). The proposed strategies make use of services such as migration, replication, MapReduce simulation, and combined processing methods (batch- and streaming-based). Via these services, a distribution of tasks for the best balance of computational resources is achieved, while monitoring and management can be performed asynchronously in the background. %An application of batch and stream-based methods are proposed to reduce the latency.
Published: 2017
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44. Electronic Participation: 9th IFIP WG 8.5 International Conference, ePart 2017, St. Petersburg, Russia, September 4-7, 2017, Proceedings

Author: Parycek, Peter, Charalabidis, Yannis, Chugunov, Andrei V., Panagiotopoulos, Panos, Pardo, Theresa A., Sæbø, Øystein, Tambouris, Efthimios, Danube University Krems, University of the Aegean, National Research University of Information Technologies, Mechanics and Optics [St. Petersburg] (ITMO), Queen Mary University of London (QMUL), University at Albany [SUNY], State University of New York (SUNY), University of Agder (UIA), University of Macedonia [Thessaloniki] (UoM), TC 8, and WG 8.5
Subjects: [INFO]Computer Science [cs]
Abstract: International audience; Book Front Matter of LNCS 10429
Published: 2017
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45. Structural classification of wild boar (Sus scrofa) vocalizations

Author: Christian T. Herbst, W. Tecumseh Fitch, Daniel L. Bowling, Markus Boeckle, Bruno Gingras, Yann Locatelli, Maxime Garcia, Boeckle, Markus [0000-0002-0738-2764], Apollo - University of Cambridge Repository, Department of Cognitive Biology, University of Vienna [Vienna], Voice Research Laboratory, Department of Biophysics, Faculty of Science, Palacky University Olomouc, Department of Psychotherapy and Biopsychosocial Health, Danube University Krems, Physiologie de la reproduction et des comportements [Nouzilly] (PRC), Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours-Centre National de la Recherche Scientifique (CNRS), Direction des Jardins botaniques et zoologiques, Muséum national d'Histoire naturelle (MNHN), The European Science Foundation 'Adavnces in Farm Animal Genomic Resource', and Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS)
Subjects: 0106 biological sciences, [SDV.OT]Life Sciences [q-bio]/Other [q-bio.OT], Spectral flux, Multivariate analysis, Context (language use), bien-être animal, Biology, 010603 evolutionary biology, 01 natural sciences, mammifère sauvage, domestication, sus scrofa, vocalisation, 0501 psychology and cognitive sciences, porcin, 050102 behavioral science & comparative psychology, Domestication, sanglier, Ecology, Evolution, Behavior and Systematics, vocal repertoire, Communication, Animal Welfare (journal), acoustic communication, business.industry, Repertoire, 05 social sciences, graded vocalizations, Research Papers, Domestic pig, Variation (linguistics), Animal Science and Zoology, business, wild boar, Research Paper, Cognitive psychology, Autre (Sciences du Vivant)
Abstract: Determining whether a species' vocal communication system is graded or discrete requires definition of its vocal repertoire. In this context, research on domestic pig (Sus scrofa domesticus) vocalizations, for example, has led to significant advances in our understanding of communicative functions. Despite their close relation to domestic pigs, little is known about wild boar (Sus scrofa) vocalizations. The few existing studies, conducted in the 1970s, relied on visual inspections of spectrograms to quantify acoustic parameters and lacked statistical analysis. Here, we use objective signal processing techniques and advanced statistical approaches to classify 616 calls recorded from semi‐free ranging animals. Based on four spectral and temporal acoustic parameters—quartile Q25, duration, spectral flux, and spectral flatness—extracted from a multivariate analysis, we refine and extend the conclusions drawn from previous work and present a statistically validated classification of the wild boar vocal repertoire into four call types: grunts, grunt‐squeals, squeals, and trumpets. While the majority of calls could be sorted into these categories using objective criteria, we also found evidence supporting a graded interpretation of some wild boar vocalizations as acoustically continuous, with the extremes representing discrete call types. The use of objective criteria based on modern techniques and statistics in respect to acoustic continuity advances our understanding of vocal variation. Integrating our findings with recent studies on domestic pig vocal behavior and emotions, we emphasize the importance of grunt‐squeals for acoustic approaches to animal welfare and underline the need of further research investigating the role of domestication on animal vocal communication.
Published: 2016
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46. Electronic Government

Author: Scholl, Hans Jochen, Glassey, Olivier, Janssen, Marijn, Klievink, Bram, Lindgren, Ida, Parycek, Peter, Tambouris, Efthimios, Wimmer, Maria A., Janowski, Tomasz, Sá Soares, Delfina, University of Washington [Seattle], Université de Lausanne (UNIL), Delft University of Technology (TU Delft), Linköping University (LIU), Donau-Universität Krems (Danube University Krems), University of Macedonia [Thessaloniki] (UoM), Universität Koblenz-Landau [Koblenz], University of Minho [Braga], TC 8, and WG 8.5
Subjects: [INFO]Computer Science [cs]
Abstract: International audience; Book Front Matter of LNCS 9820
Published: 2016
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47. Identification in E-Participation: Between Quality of Identification Data and Participation Threshold

Author: Judith Schossböck, Peter Parycek, Bettina Rinnerbauer, Danube University Krems, TC 8, and WG 8.5
Subjects: Identification methods, Authentication, E-participation, Identification, e-participation, media_common.quotation_subject, [SHS.INFO]Humanities and Social Sciences/Library and information sciences, Data quality, Computer security, computer.software_genre, Data science, Identification (information), Political science, Quality (business), [INFO]Computer Science [cs], computer, media_common
Abstract: Part 3: Evaluation; International audience; E-participation projects have to consider a low participation threshold while maintaining security and data quality standards. While users often perceive complex regulations and logins as hurdles for participation, providers of solutions want to avoid misuse and in some cases have identified the participants uniquely. Not all levels of e-participation require the same quality of identification and authentication to produce reliable outcomes. Based on the first results of an Austrian e-participation project, the paper presents a model that tries to match these complex relations and examines which identification methods are seen as appropriate on which levels of e-participation based on the dimensions of quality of identification data and low participation threshold.
Published: 2015
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48. Practical guidance for CD management involving treatment of botulinum toxin: a consensus statement

Author: Maja Relja, Elena Moro, Alberto Albanese, Giovanni Abbruzzese, Wojciech Duzynski, Pablo Mir, Michaela M. Pinter, Dirk Dressler, Cesare Montecucco, Emmanuel Roze, Inger Marie Skogseid, María José Martí, Charalampos Tzoulis, Sofiya Timerbaeva, Svetlana Khatkova, Fondazione IRCCS Istituto Neurologico 'Carlo Besta', Dipartimento di Neuroscienze, riabilitazione, oftalmologia, genetica e scienze materno-infantili [Genova] (DINOGMI), Università degli studi di Genova = University of Genoa (UniGe), Department of Neurology, Hannover Medical School [Hannover] (MHH), Section of neurology, Lund University [Lund], Neurologcal department for post-stroke patients, Moscow federal state hospital, Parkinson Disease Unit, ICN. CIBERNED. IDIBAPS. Universitat de Barcelona, Centro de Investigacion Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III [Madrid] (ISC)-Instituto de Salud Carlos III [Madrid] (ISC), Hospital Universitario Virgen del Rocío [Sevilla], Unidad de Trastornos del movimiento, IBiS, Universidad de Sevilla / University of Sevilla, Department of biomedical sciences, Università degli Studi di Padova = University of Padua (Unipd), Centre Mémoire de Ressources et de Recherche [Grenoble] (CMRR), Centre Hospitalier Universitaire [Grenoble] (CHU), Center for Neurorehabilitation, Danube-University Krems, Zagreb University Hospital, Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Department of neurology, Akershus University Hospital [Lørenskog], Department of neurogenetics, MOSCOW UNIVERSITY, Haukeland University Hospital, University of Bergen (UiB)-University of Bergen (UiB), Department of clinical medicine, Bergen University College, Universita degli studi di Genova, Lund University, Lund, Sweden, Universidad de Sevilla, Universita degli Studi di Padova, Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Centre National de la Recherche Scientifique (CNRS), Service de neurologie 1 [CHU Pitié-Salpétrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de Neurologie [CHU Pitié-Salpêtrière], IFR70-CHU Pitié-Salpêtrière [AP-HP], Administateur, HAL Sorbonne Université, and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)
Subjects: medicine.medical_specialty, Neurology, Botulinum Toxins, Consensus, Neurotoxins, Alternative medicine, Clinical Neurology, Review, Quality of life (healthcare), Botulinum toxin type A, Medicine, Humans, Cervical dystonia, Goal setting, Torticollis, Dystonia, business.industry, [SCCO.NEUR]Cognitive science/Neuroscience, [SCCO.NEUR] Cognitive science/Neuroscience, medicine.disease, 3. Good health, Clinical trial, Settore MED/26 - NEUROLOGIA, Consensus development conference, Practice Guidelines as Topic, Physical therapy, Neurology (clinical), business, Decision making, Botulinum toxins
Abstract: International audience; Cervical dystonia is a neurological movement disorder causing abnormal posture of the head. It may be accompanied by involuntary movements which are sometimes tremulous. The condition has marked effects on patients’ self-image, and adversely affects quality of life, social relationships and employment. Botulinum neurotoxin (BoNT) is the treatment of choice for CD and its efficacy and safety have been extensively studied in clinical trials. However, current guidelines do not provide enough practical information for physicians who wish to use this valuable treatment in a real-life setting. In addition, patients and physicians may have different perceptions of what successful treatment outcomes should be. Consequently, an international group of expert neurologists, experienced in BoNT treatment, met to review the literature and pool their extensive clinical experience to give practical guidance about treatment of CD with BoNT. Eight topic headings were considered: the place of BoNT within CD treatment options; patient perspectives and desires for treatment; assessment and goal setting; starting treatment with BoNT-A; follow-up sessions; management of side effects; management of non-response; switching between different BoNT products. One rapporteur took responsibility for summarising the current literature for each topic, while the consensus statements were developed by the entire expert group. These statements are presented here along with a discussion of the background information.
Published: 2015
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49. Electronic Government: 14th IFIP WG 8.5 International Conference, EGOV 2015, Thessaloniki, Greece, August 30-September 2, 2015

Author: Tambouris, Efthimios, Janssen, Marijn, Scholl, Hans Jochen, Wimmer, Maria A., Tarabanis, Konstantinos, Gascó, Mila, Klievink, Bram, Lindgren, Ida, Parycek, Peter, University of Western Macedonia [Kozani] (UoWM), Delft University of Technology (TU Delft), University of Washington [Seattle], Universität Koblenz-Landau [Koblenz], ESADE Barcelona - Sant Cugat, Linköping University (LIU), Danube University Krems, TC 8, and WG 8.5
Subjects: [INFO]Computer Science [cs]
Abstract: International audience; Book Front Matter of LNCS 9248
Published: 2015
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50. New genetic loci link adipose and insulin biology to body fat distribution

Author: Shungin, Dmitry, Winkler, Thomas W, Workalemahu, Tsegaselassie, Hartman, Catharina A, Duncan, Emma L, Ntzani, Evangelia E, Oei, Ling, Albagha, Omar M E, Amin, Najaf, Kemp, John P, Koller, Daniel L, Li, Guo, Liu, Ching-Ti, Minster, Ryan L, Hassinen, Maija, Moayyeri, Alireza, Vandenput, Liesbeth, Willner, Dana, Xiao, Su-Mei, Yerges-Armstrong, Laura M, Zheng, Hou-Feng, Alonso, Nerea, Eriksson, Joel, Kammerer, Candace M, Kaptoge, Stephen K, Hayward, Caroline, Leo, Paul J, Thorleifsson, Gudmar, Wilson, Scott G, Wilson, James F, Aalto, Ville, Alen, Markku, Aragaki, Aaron K, Aspelund, Thor, Center, Jacqueline R, Dailiana, Zoe, Heikkilä, Kauko, Duggan, David J, Garcia, Melissa, Garcia-Giralt, Natàlia, Giroux, Sylvie, Hallmans, Göran, Hocking, Lynne J, Husted, Lise Bjerre, Jameson, Karen A, Khusainova, Rita, Kim, Ghi Su, Herzig, Karl-Heinz, Kooperberg, Charles, Koromila, Theodora, Kruk, Marcin, Laaksonen, Marika, Lacroix, Andrea Z, Lee, Seung Hun, Leung, Ping C, Lewis, Joshua R, Masi, Laura, Mencej-Bedrac, Simona, Helmer, Quinta, Nguyen, Tuan V, Nogues, Xavier, Patel, Millan S, Prezelj, Janez, Rose, Lynda M, Scollen, Serena, Siggeirsdottir, Kristin, Smith, Albert V, Svensson, Olle, Trompet, Stella, Hillege, Hans L, Trummer, Olivia, van Schoor, Natasja M, Woo, Jean, Zhu, Kun, Balcells, Susana, Brandi, Maria Luisa, Buckley, Brendan M, Cheng, Sulin, Christiansen, Claus, Cooper, Cyrus, Holmen, Oddgeir, Dedoussis, George, Ford, Ian, Frost, Morten, Goltzman, David, González-Macías, Jesús, Kähönen, Mika, Karlsson, Magnus, Khusnutdinova, Elza, Koh, Jung-Min, Kollia, Panagoula, Hunt, Steven C, Langdahl, Bente Lomholt, Leslie, William D, Lips, Paul, Ljunggren, Östen, Lorenc, Roman S, Marc, Janja, Mellström, Dan, Obermayer-Pietsch, Barbara, Olmos, José M, Pettersson-Kymmer, Ulrika, Isaacs, Aaron, Reid, David M, Riancho, José A, Ridker, Paul M, Rousseau, François, Slagboom, P Eline, Tang, Nelson L S, Urreizti, Roser, Van Hul, Wim, Viikari, Jorma, Zarrabeitia, María T, Wu, Joseph M W, Ittermann, Till, Aulchenko, Yurii S, Castano-Betancourt, Martha, Grundberg, Elin, Herrera, Lizbeth, Ingvarsson, Thorvaldur, Johannsdottir, Hrefna, Kwan, Tony, Li, Rui, Luben, Robert, Medina-Gómez, Carolina, James, Alan L, Palsson, Stefan Th, Reppe, Sjur, Rotter, Jerome I, Sigurdsson, Gunnar, van Meurs, Joyce B J, Verlaan, Dominique, Williams, Frances M K, Wood, Andrew R, Zhou, Yanhua, Gautvik, Kaare M, Johansson, Ingegerd, Pastinen, Tomi, Raychaudhuri, Soumya, Cauley, Jane A, Chasman, Daniel I, Clark, Graeme R, Cummings, Steven R, Danoy, Patrick, Dennison, Elaine M, Eastell, Richard, Eisman, John A, Juliusdottir, Thorhildur, Gudnason, Vilmundur, Hofman, Albert, Jackson, Rebecca D, Jones, Graeme, Jukema, J Wouter, Khaw, Kay-Tee, Lehtimäki, Terho, Liu, Yongmei, Lorentzon, Mattias, McCloskey, Eugene, Kalafati, Ioanna-Panagiota, Mitchell, Braxton D, Nandakumar, Kannabiran, Nicholson, Geoffrey C, Oostra, Ben A, Peacock, Munro, Pols, Huibert A P, Prince, Richard L, Raitakari, Olli, Reid, Ian R, Robbins, John, Kinnunen, Leena, Sambrook, Philip N, Sham, Pak Chung, Shuldiner, Alan R, Tylavsky, Frances A, van Duijn, Cornelia M, Wareham, Nick J, Cupples, L Adrienne, Econs, Michael J, Evans, David M, Harris, Tamara B, Koenig, Wolfgang, Kung, Annie Wai Chee, Psaty, Bruce M, Reeve, Jonathan, Spector, Timothy D, Streeten, Elizabeth A, Zillikens, M Carola, Thorsteinsdottir, Unnur, Ohlsson, Claes, Karasik, David, Richards, J Brent, Kooner, Ishminder K, Brown, Matthew A, Stefansson, Kari, Uitterlinden, André G, Ralston, Stuart H, Ioannidis, John P A, Kiel, Douglas P, Rivadeneira, Fernando, Sandholm, Niina, Salem, Rany M, McKnight, Amy Jayne, Kratzer, Wolfgang, Brennan, Eoin P, Forsblom, Carol, Isakova, Tamara, McKay, Gareth J, Williams, Winfred W, Sadlier, Denise M, Mäkinen, Ville-Petteri, Swan, Elizabeth J, Palmer, Cameron, Boright, Andrew P, Lamina, Claudia, Ahlqvist, Emma, Deshmukh, Harshal A, Keller, Benjamin J, Huang, Huateng, Ahola, Aila, Fagerholm, Emma, Gordin, Daniel, Harjutsalo, Valma, He, Bing, Heikkilä, Outi, Buchkovich, Martin L, Leander, Karin, Hietala, Kustaa, Kytö, Janne, Lahermo, Päivi, Lehto, Markku, Österholm, Anne-May, Parkkonen, Maija, Pitkäniemi, Janne, Rosengård-Bärlund, Milla, Saraheimo, Markku, Sarti, Cinzia, Lee, Nanette R, Söderlund, Jenny, Soro-Paavonen, Aino, Syreeni, Anna, Thorn, Lena M, Tikkanen, Heikki, Tolonen, Nina, Tryggvason, Karl, Tuomilehto, Jaakko, Wadén, Johan, Gill, Geoffrey V, Lichtner, Peter, Prior, Sarah, Guiducci, Candace, Mirel, Daniel B, Taylor, Andrew, Hosseini, Mohsen, Parving, Hans-Henrik, Rossing, Peter, Tarnow, Lise, Ladenvall, Claes, Alhenc-Gelas, François, Lind, Lars, Lefebvre, Pierre, Rigalleau, Vincent, Roussel, Ronan, Tregouet, David-Alexandre, Maestroni, Anna, Maestroni, Silvia, Falhammar, Henrik, Gu, Tianwei, Möllsten, Anna, Cimponeriu, Dan, Lindström, Jaana, Mihai, Ioana, Mota, Maria, Mota, Eugen, Serafinceanu, Cristian, Stavarachi, Monica, Hanson, Robert L, Nelson, Robert G, Kretzler, 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C., Rice, Treva K, Ritchie, Marylyn D, Sarzynski, Mark A, Schwarz, Peter Eh, Steinthorsdottir, Valgerdur, Strauch, Konstantin, Tönjes, Anke, Tremblay, Angelo, Vohl, Marie-Claude, Witteman, Jacqueline C, Bouchard, Claude, Cauchi, Stéphane, Grabe, Hans-Jörgen, Jöckel, Karl-Heinz, Anderson, Denise, Palmer, Colin Na, Beekman, Marian, Pérusse, Louis, Sinisalo, Juha, Veronesi, Giovanni, Buyske, Steven, Walker, Mark, Abecasis, Goncalo R, Berndt, Sonja I, Kaplan, Robert C, Qi, Lu, Locke, Adam E, Yang, Jian, Speliotes, Elizabeth K, Fox, Caroline S, Heid, Iris M, Loos, Ruth Jf, Dastani, Zari, Timpson, Nicholas, Yuan, Xin, Henneman, Peter, Kizer, Jorge R, Lyytikainen, Leo-Pekka, Fuchsberger, Christian, Coassin, Stefan, Lohman, Kurt, Uh, Hae-Won, Bidulescu, Aurelian, Greenwood, Celia M T, Ladouceur, Martin, Grimsby, Jonna, Manning, Alisa K, Kooner, Jaspal, Mooser, Vincent E, Kapur, Karen A, Chambers, John, Frants, Rune, Willemsvan-vanDijk, Ko, Kristiansson, Kati, Winkler, Thomas, Tracy, Russell P, 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P., Esko, T., Fall, T., Chen, H., Robertson, N., Rybin, D., Chines, PS., Song, K., An, P., Marullo, L., Jansen, H., Oldehinkel, AJ., North, KE., Forouhi, NG., Edkins, S., Varga, TV., Oksa, H., Antonella, M., Kong, A., Herder, C., Antti, J., Miljkovic, I., Atalay, M., Kiess, W., James, AL., Smit, JH., Campbell, S., Fowkes, GR., Basart, HV., Rathmann, W., Maerz, W., Province, MA., Watanabe, RM., de Geus EJ., Penninx, BW., Oostra, B., Toenjes, A., Peyser, PA., Körner, A., Keinanen-Kiukaanniemi, SM., Saaristo, TE., Boomsma, D., Cucca, F., Balkau, B., Froguel, P., Jarvelin, MR., Bouatia-Naji, N., Ahmadi, KR., Ainali, C., Barrett, A., Bataille, V., Bell, JT., Buil, A., Dermitzakis, ET., Dimas, AS., Durbin, R., Glass, D., Hassanali, N., Hedman£££Åsa K£££ ÅK., Ingle, C., Keildson, S., Knowles, D., Krestyaninova, M., Lowe, CE., Meduri, E., di Meglio, P., Min, JL., Montgomery, SB., Nestle, FO., Nica, AC., Nisbet, J., O'Rahilly, S., Parts, L., Potter, S., Sekowska, M., Shin, SY., Small, KS., Surdulescu, G., Travers, ME., Tsaprouni, L., Tsoka, S., Wilk, A., Matise, T., Buyske, S., Higashio, J., Williams, R., Nato, A., Ambite, JL., Deelman, E., Manolio, T., Hindorff, L., Heiss, G., Taylor, K., Avery, C., Graff, M., Lin, D., Quibrera, M., Cochran, B., Kao, L., Umans, J., Cole, S., MacCluer, J., Person, S., Pankow, J., Gross, M., Fornage, M., Durda, P., Jenny, N., Patsy, B., Arnold, A., Buzkova, P., Crawford, D., Haines, J., Murdock, D., Glenn, K., Brown-Gentry, K., Thornton-Wells, T., Dumitrescu, L., Jeff, J., Bush, WS., Mitchell, SL., Goodloe, R., Wilson, S., Boston, J., Malinowski, J., Restrepo, N., Oetjens, M., Fowke, J., Zheng, W., Spencer, K., Ritchie, M., Pendergrass, S., Le Marchand£££Loïc£££ L., Wilkens, L., Park, L., Tiirikainen, M., Kolonel, L., Lim, U., Cheng, I., Wang, H., Shohet, R., Haiman, C., Stram, D., Henderson, B., Monroe, K., Schumacher, F., Peters, U., Anderson, G., Carlson, C., Prentice, R., LaCroix, A., Wu, C., Carty, C., Gong, J., Rosse, S., Young, A., Haessler, J., Kocarnik, J., Lin, Y., Jackson, R., Duggan, D., Kuller, L., Stolk, L., He, C., Sulem, P., Barbalic, M., Broer, L., Byrne, EM., Gudbjartsson, DF., McArdle, PF., Porcu, E., van Wingerden, S., Zhuang, W., Albrecht, E., Alizadeh, BZ., Lauc, LB., Broekmans, FJ., Burri, A., Chanock, SJ., Chen, C., Corre, T., Coviello, AD., d'Adamo, P., Davies, G., Deary, IJ., Ebrahim, S., Fauser, BC., Ferreli, L., Folsom, AR., Garcia, ME., Hall, P., Haller, T., Hankinson, SE., Hass, M., Heath, AC., Janssens, AC., Keyzer, J., Lahti, J., Lai, S., Laisk, T., Laven, JS., Liu, J., Lopez, LM., Louwers, YV., Marongiu, M., Klaric, IM., Masciullo, C., McKnight, B., Medland, SE., Melzer, D., Newman, AB., Paré, G., Peeters, PH., Plump, AS., Pop, VJ., Räikkönen, K., Salumets, A., Smith, JA., Stacey, SN., Starr, JM., Stathopoulou, MG., Tenesa, A., Thorand, B., Tryggvadottir, L., Tsui, K., van Dam RM., van Gils CH., van Nierop, P., Vink, JM., Voorhuis, M., Wallaschofski, H., Widen, E., Wijnands-van Gent CJ., Zgaga, L., Zygmunt, M., Arnold, AM., Buring, JE., Crisponi, L., Demerath, EW., Hunter, DJ., Schlessinger, D., Murray, A., Murabito, JM., Visser, JA., Lunetta, KL., Elks, CE., Cousminer, DL., Feenstra, B., Lin, P., van Wingerden SW., Smith, EN., Warrington, NM., Alavere, H., Barroso, I., Berenson, GS., Blackburn, H., Busonero, F., Chen, W., Couper, D., Easton, DF., Foroud, T., Geller, F., Hernandez, DG., Kilpeläinen, TO., Li, S., Melbye, M., Murray, JC., Murray, SS., Nelis, M., Ness, AR., Northstone, K., Pennell, CE., Pharoah, P., Rafnar, T., Rice, JP., Ring, SM., Schork, NJ., Segrè, AV., Sovio, U., Srinivasan, SR., Tammesoo, ML., Tyrer, J., Weedon, MN., Wichmann, H., Young, L., Zhuang, WV., Bierut, LJ., Boyd, HA., Department of Clinical Sciences, Lund University [Lund], Genetic Epidemiology and Clinical Research Group, Umea University Hospital, Department of Odontology, Umeå University, Signalisation et Transports Ioniques Membranaires (STIM), Université de Poitiers-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS), Department of Medical Sciences, Center for Biological Sequence Analysis [Lyngby], Danmarks Tekniske Universitet = Technical University of Denmark (DTU), Laboratory of Image Science and Technology [Nanjing] (LIST), Southeast University [Jiangsu]-School of Computer Science and Engineering, Limnology, Ecology, Estonian Genome and Medicine, University of Tartu, Institute of Molecular and Cell Biology, Department of Medical Epidemiology and Biostatistics (MEB), Karolinska Institutet [Stockholm], Department of Medical Genetics, Université de Lausanne = University of Lausanne (UNIL), Institute of Medical Informatics, Biometry and Epidemiology, Universität Duisburg-Essen = University of Duisburg-Essen [Essen], Centre d'Immunologie de Marseille - Luminy (CIML), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Genetic Epidemiology Unit, Erasmus University Medical Center [Rotterdam] (Erasmus MC), Space Sciences Laboratory [Berkeley] (SSL), University of California [Berkeley] (UC Berkeley), University of California (UC)-University of California (UC), Department of Biostatistics and Center for Statistical Genetics, University of Michigan [Ann Arbor], University of Michigan System-University of Michigan System, Division of Statistical Genomics, Washington University School of Medicine, King‘s College London, Department of Medicine, University of Eastern Finland-Kuopio University Hospital, Molecular Genetics Section, University of Groningen [Groningen]-University Medical Centre Groningen, Metabolic functional (epi)genomics and molecular mechanisms involved in type 2 diabetes and related diseases - UMR 8199 - UMR 1283 (EGENODIA (GI3M)), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Geriatric Rehabilitation Unit, Azienda Sanitaria Firenze, Department of Pharmacy Sciences, Creighton University Medical Center, Medical Department III, Universität Leipzig, Foie, métabolismes et cancer, Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Department of Epidemiology, Erasmus Medical Centre, Netherlands Genomics Initiative (NGI), Netherlands Genomics Initiative, Institute of Epidemiology [Neuherberg] (EPI), German Research Center for Environmental Health - Helmholtz Center München (GmbH), Department of Public Health and Clinical Medicine, Medstar Research Institute, Genetics and Pathology, Finnish Institute of Occupational Health, Epidemiology, University Medical Centre Groningen, Departments of Microbiology & Molecular Genetics and Molecular Biology & Biochemistry, University of California [Irvine] (UC Irvine), Department of Odontology, Cariology, Institute of Human Genetics, Helmholtz Zentrum München = German Research Center for Environmental Health, Génétique des maladies multifactorielles (GMM), Université de Lille, Droit et Santé-Centre National de la Recherche Scientifique (CNRS), Division of Cardiology, Geneva University Hospital (HUG), Department of Psychiatry and Psychotherapy, Rheinische Friedrich-Wilhelms-Universität Bonn, Department of Physics, Indian Institute of Technology Kanpur (IIT Kanpur), University of North Carolina [Chapel Hill] (UNC), University of North Carolina System (UNC)-University of North Carolina System (UNC), Department of Genomics, Life and Brain Center, Universität Bonn = University of Bonn, Anaesthesia and Intensive care, Royal Aberdeen Childrens Hospital, UCL Institute of neurology, UCL Institute of Neurology, Human Genetics, The Wellcome Trust Sanger Institute [Cambridge], Departments of Epidemiology and Nutrition, Harvard School of Public Health, Institute of Experimental Medicine, Czech Academy of Sciences [Prague] (CAS), Department of Medical Sciences and Uppsala Clinical Research Center, Uppsala University Hospital, Department of Genetics, University of Groningen [Groningen], deCODE Genetics, deCODE genetics [Reykjavik], Pediatric Pulmonology, Allergology & Epidemiology, University of Groningen [Groningen]-University Medical Center Groningen [Groningen] (UMCG)-Beatrix Children's Hospital-Groningen Research Institute for Asthma and COPD, Department of Nutrition-Dietetics, Harokopio University of Athens, Yale School of Medicine [New Haven, Connecticut] (YSM), National Heart and Lung Institute (NHLI), Imperial College London, Queensland Institute of Medical Research, Concord Hospital, Epidémiologie des maladies chroniques : impact des interactions gène environnement sur la santé des populations, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé, Dept. 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Greifswald - University of Greifswald, Interfaculty Institute for Genetics and Functional Genomics, 5 University Street, Centre for Paediatric Epidemiology and Biostatistics, University College of London [London] (UCL), MRC Centre for Epidemiology of Child Health, UCL Institute of Child Health, Unit for Molecular Epidemiology, Institute of Health Sciences and Biocenter Oulu, University of Oulu, Department of Epidemiology and Biostatistics, Department of Life Course and Services, National Institute for Health and Welfare [Helsinki], Department of Epidemiology and Public Health, Queen's University [Belfast] (QUB), Interdisciplinary Center of Clinical Research, Department of Physiology, University of Eastern Finland-Institute of Biomedicine, University of Hawai‘i [Mānoa] (UHM), Department of Clinical Chemistry, University of Tampere [Finland]-Tampere University Hospital, Chronic Disease Epidemiology and Prevention Unit, Université Laval [Québec] (ULaval), Centre for Bone and Arthritis Research, University of Gothenburg (GU)-Institute of Medicine, Interdisciplinary Center for Psychiatric Epidemiology, Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, The Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Department of Clinical Physiology, Turku University Hospital (TYKS), Brigham and Women's Hospital [Boston], Department of Chronic Disease Prevention, Department of Cardiovascular Sciences [Leicester], University of Leicester, Leicester NIHR Biomedical Research Unit in Cardiovascular Disease, Maastricht University [Maastricht], Institute of Social and Preventive Medicine, Lausanne University Hospital, Carl Gustav Carus University Hospital, Recherches en Psychopathologie, nouveaux symptômes et lien social (EA 4050), Université de Poitiers-Université de Brest (UBO)-Université Catholique de l'Ouest (UCO)-Université de Rennes 2 (UR2), Institut de biologie de Lille - UMS 3702 (IBL), 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= University of Helsinki, Unit of Genetic Epidemiology and Bioinformatics, Department of Epidemiology, University Medical Center Groningen, Department of Pediatrics, Augusta University - Medical College of Georgia, University System of Georgia (USG)-University System of Georgia (USG), Department of Public Health, South Ostrobothnia Central Hospital, Department of Clinical and Preventive Medicine, Danube-University Krems, Netherlands Consortium for Healthy Aging [Leiden, Netherlands] (NCHA), Institute of Public Health and Clinical Nutrition, University of Eastern Finland, MRC epidemiology Unit, Institute of Epidemiology, Clinical Genetics Branch, Division of Cancer Epidemiology & Genetics, National Institutes of Health [Bethesda] (NIH)-National Cancer Institute [Bethesda] (NCI-NIH), National Institutes of Health [Bethesda] (NIH), Department of Oncology, Queensland Brain Institute, University of Queensland [Brisbane], Harvard Reproductive Sciences Center and Reproductive Endocrine Unit, Massachusetts General Hospital [Boston], Divisions of Genetics and Endocrinology and Program in Genomics, Boston Children's Hospital, Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute of MIT and Harvard (BROAD INSTITUTE), Harvard Medical School [Boston] (HMS)-Massachusetts Institute of Technology (MIT)-Massachusetts General Hospital [Boston]-Harvard Medical School [Boston] (HMS)-Massachusetts Institute of Technology (MIT)-Massachusetts General Hospital [Boston], University of North Carolina System (UNC)-University of North Carolina System (UNC)-UNC Gillings School of Global Public Health-Carolina Center for Genome Sciences, Metabolic Disease Group, University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Department of Epidemiology and Preventive Medicine, Regensburg University Medical Center, Epidemiology Unit, Addenbrooke's Hospital-Medical Research Council (MRC), Framingham Heart Study, Boston University [Boston] (BU)-National Heart, Lung, and Blood Institute [Bethesda] (NHLBI), Endocrinology and Metabolism, The Churchill Hospital-Oxford Centre for Diabetes, Landsteiner Laboratory, Clinical Haematology, Other departments, ACS - Amsterdam Cardiovascular Sciences, Vascular Medicine, Lund University Diabetes Centre-Lund University [Lund], Université de Tours-Centre National de la Recherche Scientifique (CNRS)-Université de Poitiers, Technical University of Denmark [Lyngby] (DTU), Université de Lausanne (UNIL), Universität Duisburg-Essen [Essen], Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), University of California [Berkeley], University of California-University of California, Génomique Intégrative et Modélisation des Maladies Métaboliques (EGID), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS), Universität Leipzig [Leipzig], Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), University of California [Irvine] (UCI), German Research Center for Environmental Health, University of Bonn, Czech Academy of Sciences [Prague] (ASCR), Yale University School of Medicine, University of Oxford [Oxford], German Research Center for Environmental Health-Helmholtz-Zentrum München (HZM), Laval University, Laval University [Québec], Turku University Hospital, Lausanne university hospital, Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Institut de biologie de Lille - IBL (IBLI), Université de Lille, Sciences et Technologies-Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Université de Lille, Droit et Santé-Centre National de la Recherche Scientifique (CNRS), University of Helsinki-University of Helsinki, Helmholtz-Zentrum München (HZM), National Heart, Lung, and Blood Institute [Bethesda] (NHLBI)-Boston University [Boston] (BU), Internal Medicine, Child and Adolescent Psychiatry / Psychology, Clinical Genetics, Medical Informatics, Obstetrics & Gynecology, Lund University [Lund]-Lund University Diabetes Centre, Metabolic functional (epi)genomics and molecular mechanisms involved in type 2 diabetes and related diseases - UMR 8199 - UMR 1283 (GI3M), Institute of Medicine-University of Gothenburg (GU), Signalisation et Transports Ioniques Membranaires ( STIM ), Université de Poitiers-Centre National de la Recherche Scientifique ( CNRS ), Technical University of Denmark [Lyngby] ( DTU ), Laboratory of Image Science and Technology [Nanjing] ( LIST ), Department of Medical Epidemiology and Biostatistics ( MEB ), University of Lausanne, Centre d'Immunologie de Marseille - Luminy ( CIML ), Aix Marseille Université ( AMU ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Erasmus MC, Space Sciences Laboratory [Berkeley] ( SSL ), Génomique Intégrative et Modélisation des Maladies Métaboliques ( EGID ), Université de Lille-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Institut Pasteur de Lille, Réseau International des Instituts Pasteur ( RIIP ) -Réseau International des Instituts Pasteur ( RIIP ) -Centre National de la Recherche Scientifique ( CNRS ) -Centre Hospitalier Régional Universitaire [Lille] ( CHRU Lille ), University of Leipzig, Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Institute of Epidemiology [Neuherberg] ( EPI ), University of California [Irvine] ( UCI ), Génétique des maladies multifactorielles ( GMM ), Université de Lille, Droit et Santé-Centre National de la Recherche Scientifique ( CNRS ), Geneva University Hospital ( HUG ), Bonn Universität [Bonn], Indian Institute of Technology Kanpur ( IIT Kanpur ), The University of North Carolina at Chapel Hill, Université de Bonn, Wellcome Trust Sanger Institute, Harvard University School of Public Health, Czech Academy of Sciences [Prague] ( ASCR ), deCODE genetics, University of Groningen [Groningen]-University Medical Center Groningen-Beatrix Children's Hospital-Groningen Research Institute for Asthma and COPD, Yale School of Medicine, National Heart and Lung Institute ( NHLI ), Réseau International des Instituts Pasteur ( RIIP ) -Réseau International des Instituts Pasteur ( RIIP ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université de Lille, Droit et Santé, University Medical Center Groningen, University of Cambridge [UK] ( CAM ), Wellcome Trust Centre for Human Genetics, University of Pisa [Pisa], University of Cambridge [UK] ( CAM ) -Institute of Metabolic Science, German Research Center for Environmental Health-Helmholtz-Zentrum München ( HZM ), University of Otago, University of Greifswald, University College of London [London] ( UCL ), National Institute for Health and Welfare, Queen's University [Belfast] ( QUB ), University of Hawaii at Manoa ( UHM ), University of Gothenburg ( GU ) -Institute of Medicine, Recherches en Psychopathologie, nouveaux symptômes et lien social ( EA 4050 ), Université de Poitiers-Université de Brest ( UBO ) -Université Catholique de l'Ouest-Université de Rennes 2 ( UR2 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ), Institut de biologie de Lille - IBL ( IBLI ), Réseau International des Instituts Pasteur ( RIIP ) -Réseau International des Instituts Pasteur ( RIIP ) -Université de Lille, Droit et Santé-Centre National de la Recherche Scientifique ( CNRS ), Institut Cochin ( UM3 (UMR 8104 / U1016) ), Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), University Medicine Greifswald,-HELIOS Hospital Stralsund, Finland Institute for Molecular Medicine ( FIMM ), Georgia Prevention Institute, Netherlands Consortium for Healthy Aging, Helmholtz-Zentrum München ( HZM ), National Institutes of Health ( NIH ) -National Cancer Institute ( NIH ), Massachusetts General Hospital, Children's Hospital, Boston, Broad Institute, Cambridge, MA, The University of North Carolina at Chapel Hill-UNC Gillings School of Global Public Health-Carolina Center for Genome Sciences, Shungin D, Winkler TW, Adipogen, Consortium, Cardiogramplusc4d, Consortium, Ckdgen, Consortium, Gefos, Consortium, Genie, Consortium, Glgc, Icbp, International, Endogene Consortium, Lifelines, Cohort Study, Magic, Investigator, Muther, Consortium, Consortium, Page, ReproGen Consortium, Amouyel P, D'Adamo, ADAMO PIO, Gasparini, Paolo, Shungin, Dmitry, Winkler, Thomas W, Croteau-Chonka, Damien C, Ferreira, Teresa, Hypponen, Elina, Mohlke, Karen L, ADIPOGEN Consortium, Int Endogene Consortium, Lee Kong Chian School of Medicine (LKCMedicine), Epidemiologie, RS: CARIM - R3.02 - Hypertension and target organ damage, Université de Tours-Université de Poitiers-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Biological Psychology, Neuroscience Campus Amsterdam - Neurobiology of Mental Health, EMGO+ - Lifestyle, Overweight and Diabetes, Damage and Repair in Cancer Development and Cancer Treatment (DARE), Guided Treatment in Optimal Selected Cancer Patients (GUTS), Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Life Course Epidemiology (LCE), Cardiovascular Centre (CVC), Groningen Kidney Center (GKC), Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Groningen Research Institute for Asthma and COPD (GRIAC), Groningen Institute for Organ Transplantation (GIOT), Lifestyle Medicine (LM), Center for Liver, Digestive and Metabolic Diseases (CLDM), Stem Cell Aging Leukemia and Lymphoma (SALL), Shungin, D, Winkler, T, Croteau Chonka, D, Ferreira, T, Locke, A, Mägi, R, Strawbridge, R, Pers, T, Fischer, K, Justice, A, Workalemahu, T, Wu, J, Buchkovich, M, Heard Costa, N, Roman, T, Drong, A, Song, C, Gustafsson, S, Day, F, Esko, T, Fall, T, Kutalik, Z, Luan, J, Randall, J, Scherag, A, Vedantam, S, Wood, A, Chen, J, Fehrmann, R, Karjalainen, J, Kahali, B, Liu, C, Schmidt, E, Absher, D, Amin, N, Anderson, D, Beekman, M, Bragg Gresham, J, Buyske, S, Demirkan, A, Ehret, G, Feitosa, M, Goel, A, Jackson, A, Johnson, T, Kleber, M, Kristiansson, K, Mangino, M, Leach, I, Medina Gomez, C, Palmer, C, Pasko, D, Pechlivanis, S, Peters, M, Prokopenko, I, Stanca'Kova', A, Sung, Y, Tanaka, T, Teumer, A, Van Vliet Ostaptchouk, J, Yengo, L, Zhang, W, Albrecht, E, Ärnlöv, J, Arscott, G, Bandinelli, S, Barrett, A, Bellis, C, Bennett, A, Berne, C, Blüher, M, Böhringer, S, Bonnet, F, Böttcher, Y, Bruinenberg, M, Carba, D, Caspersen, I, Clarke, R, Daw, E, Deelen, J, Deelman, E, Delgado, G, Doney, A, Eklund, N, Erdos, M, Estrada, K, Eury, E, Friedrich, N, Garcia, M, Giedraitis, V, Gigante, B, Go, A, Golay, A, Grallert, H, Grammer, T, Gräsler, J, Grewal, J, Groves, C, Haller, T, Hallmans, G, Hartman, C, Hassinen, M, Hayward, C, Heikkilä, K, Herzig, K, Helmer, Q, Hillege, H, Holmen, O, Hunt, S, Isaacs, A, Ittermann, T, James, A, Johansson, I, Juliusdottir, T, Kalafati, I, Kinnunen, L, Koenig, W, Kooner, I, Kratzer, W, Lamina, C, Leander, K, Lee, N, Lichtner, P, Lind, L, Lindström, J, Lobbens, S, Lorentzon, M, Mach, F, Magnusson, P, Mahajan, A, Mcardle, W, Menni, C, Merger, S, Mihailov, E, Milani, L, Mills, R, Moayyeri, A, Monda, K, Mooijaart, S, Mühleisen, T, Mulas, A, Müller, G, Müller Nurasyid, M, Nagaraja, R, Nalls, M, Narisu, N, Glorioso, N, Nolte, I, Olden, M, Rayner, N, Renstrom, F, Ried, J, Robertson, N, Rose, L, Sanna, S, Scharnagl, H, Scholtens, S, Sennblad, B, Seufferlein, T, Sitlani, C, Smith, A, Stirrups, K, Stringham, H, Sundström, J, Swertz, M, Swift, A, Syvänen, A, Tayo, B, Thorand, B, Thorleifsson, G, Tomaschitz, A, Troffa, C, Van Oort, F, Verweij, N, Vonk, J, Waite, L, Wennauer, R, Wilsgaard, T, Wojczynski, M, Wong, A, Zhang, Q, Zhao, J, Brennan, E, Choi, M, Eriksson, P, Folkersen, L, Franco Cereceda, A, Gharavi, A, Hedman, A, Hivert, M, Huang, J, Kanoni, S, Karpe, F, Keildson, S, Kiryluk, K, Liang, L, Lifton, R, Ma, B, Mcknight, A, Mcpherson, R, Metspalu, A, Min, J, Moffatt, M, Montgomery, G, Murabito, J, Nicholson, G, Nyholt, D, Olsson, C, Perry, J, Reinmaa, E, Salem, R, Sandholm, N, Schadt, E, Scott, R, Stolk, L, Vallejo, E, Westra, H, Zondervan, K, Amouyel, P, Arveiler, D, Bakker, S, Beilby, J, Bergman, R, Blangero, J, Brown, M, Burnier, M, Campbell, H, Chakravarti, A, Chines, P, Claudi Boehm, S, Collins, F, Crawford, D, Danesh, J, De Faire, U, De Geus, E, Dörr, M, Erbel, R, Eriksson, J, Farrall, M, Ferrannini, E, Ferrières, J, Forouhi, N, Forrester, T, Franco, O, Gansevoort, R, Gieger, C, Gudnason, V, Haiman, C, Harris, T, Hattersley, A, Heliövaara, M, Hicks, A, Hingorani, A, Hoffmann, W, Hofman, A, Homuth, G, Humphries, S, Hyppönen, E, Illig, T, Jarvelin, M, Johansen, B, Jousilahti, P, Jula, A, Kaprio, J, Kee, F, Keinanen Kiukaanniemi, S, Kooner, J, Kooperberg, C, Kovacs, P, Kraja, A, Kumari, M, Kuulasmaa, K, Kuusisto, J, Lakka, T, Langenberg, C, Le Marchand, L, Lehtimäki, T, Lyssenko, V, Männistö, S, Marette, A, Matise, T, Mckenzie, C, Mcknight, B, Musk, A, Möhlenkamp, S, Morris, A, Nelis, M, Ohlsson, C, Oldehinkel, A, Ong, K, Palmer, L, Penninx, B, Peters, A, Pramstaller, P, Raitakari, O, Rankinen, T, Rao, D, Rice, T, Ridker, P, Ritchie, M, Rudan, I, Salomaa, V, Samani, N, Saramies, J, Sarzynski, M, Schwarz, P, Shuldiner, A, Staessen, J, Steinthorsdottir, V, Stolk, R, Strauch, K, Tönjes, A, Tremblay, A, Tremoli, E, Vohl, M, Völker, U, Vollenweider, P, Wilson, J, Witteman, J, Adair, L, Bochud, M, Boehm, B, Bornstein, S, Bouchard, C, Cauchi, S, Caulfield, M, Chambers, J, Chasman, D, Cooper, R, Dedoussis, G, Ferrucci, L, Froguel, P, Grabe, H, Hamsten, A, Hui, J, Hveem, K, Jöckel, K, Kivimaki, M, Kuh, D, Laakso, M, Liu, Y, März, W, Munroe, P, Njolstad, I, Oostra, B, Pedersen, N, Perola, M, Pe'Russe, L, Peters, U, Power, C, Quertermous, T, Rauramaa, R, Rivadeneira, F, Saaristo, T, Saleheen, D, Sinisalo, J, Slagboom, P, Snieder, H, Spector, T, Thorsteinsdottir, U, Stumvoll, M, Tuomilehto, J, Uitterlinden, A, Uusitupa, M, Van Der Harst, P, Veronesi, G, Walker, M, Wareham, N, Watkins, H, Wichmann, H, Abecasis, G, Assimes, T, Berndt, S, Boehnke, M, Borecki, I, Deloukas, P, Franke, L, Frayling, T, Groop, L, Hunter, D, Kaplan, R, O'Connell, J, Qi, L, Schlessinger, D, Strachan, D, Stefansson, K, Van Duijn, C, Willer, C, Visscher, P, Yang, J, Hirschhorn, J, Zillikens, M, Mccarthy, M, Speliotes, E, North, K, Fox, C, Barroso, I, Franks, P, Ingelsson, E, Heid, I, Loos, R, Cupples, L, Lindgren, C, Mohlke, K, Dastani, Z, Timpson, N, Yuan, X, Henneman, P, Kizer, J, Lyytikainen, L, Fuchsberger, C, Small, K, Coassin, S, Lohman, K, Pankow, J, Uh, H, Wu, Y, Bidulescu, A, Rasmussen Torvik, L, Greenwood, C, Ladouceur, M, Grimsby, J, Manning, A, Mooser, V, Kapur, K, Frants, R, Willemsvan vanDijk, K, Willems, S, Psaty, B, Tracy, R, Brody, J, Chen, I, Viikari, J, Kähönen, M, Evans, D, St Pourcain, B, Sattar, N, Carlson, O, Egan, J, van Heemst, D, Kedenko, L, Nuotio, M, Loo, B, Kanaya, A, Haun, M, Klopp, N, Katsareli, E, Couper, D, Duncan, B, Kloppenburg, M, Borja, J, Musani, S, Guo, X, Semple, R, Teslovich, T, Allison, M, Redline, S, Buxbaum, S, Meulenbelt, I, Ballantyne, C, Hu, F, Paulweber, B, Florez, J, Smith, G, Siscovick, D, Kronenberg, F, van Duijn, C, Waterworth, D, Meigs, J, Dupuis, J, Richards, J, Willenborg, C, Thompson, J, Erdmann, J, Goldstein, B, König, I, Cazier, J, Johansson, Å, Hall, A, Lee, J, Grundberg, E, Havulinna, A, Ho, W, Hopewell, J, Eriksson, N, Lundmark, P, Lyytikäinen, L, Rafelt, S, Tikkanen, E, Van Zuydam, N, Voight, B, Ziegler, A, Altshuler, D, Balmforth, A, Braund, P, Burgdorf, C, Cox, D, Dimitriou, M, Do, R, El Mokhtari, N, Fontanillas, P, Hager, J, Han, B, Kang, H, Kessler, T, Knowles, J, Kolovou, G, Langford, C, Lokki, M, Lundmark, A, Meisinger, C, Melander, O, Maouche, S, Nikus, K, Peden, J, Rasheed, A, Rosinger, S, Rubin, D, Rumpf, M, Schäfer, A, Sivananthan, M, Stewart, A, Tan, S, Thorgeirsson, G, van der Schoot, C, Wagner, P, Wells, G, Wild, P, Yang, T, Basart, H, Boerwinkle, E, Brambilla, P, Cambien, F, Cupples, A, de Faire, U, Dehghan, A, Diemert, P, Epstein, S, Evans, A, Ferrario, M, Gauguier, D, Goodall, A, Hazen, S, Holm, H, Iribarren, C, Jang, Y, Kim, H, Laaksonen, R, Ouwehand, W, Parish, S, Park, J, Rader, D, Shah, S, Stark, K, Trégouët, D, Virtamo, J, Wallentin, L, Zimmermann, M, Nieminen, M, Hengstenberg, C, Sandhu, M, Pastinen, T, Hovingh, G, Zalloua, P, Siegbahn, A, Schreiber, S, Ripatti, S, Blankenberg, S, O'Donnell, C, Reilly, M, Collins, R, Kathiresan, S, Roberts, R, Schunkert, H, Pattaro, C, Köttgen, A, Garnaas, M, Böger, C, Chen, M, Tin, A, Taliun, D, Li, M, Gao, X, Gorski, M, Yang, Q, Hundertmark, C, Foster, M, O'Seaghdha, C, Glazer, N, Struchalin, M, Li, G, Johnson, A, Gierman, H, Hwang, S, Atkinson, E, Cornelis, M, Chouraki, V, Holliday, E, Sorice, R, Deshmukh, H, Ulivi, S, Chu, A, Murgia, F, Trompet, S, Imboden, M, Kollerits, B, Pistis, G, Launer, L, Aspelund, T, Eiriksdottir, G, Mitchell, B, Schmidt, H, Cavalieri, M, Rao, M, de Andrade, M, Turner, S, Ding, J, Andrews, J, Freedman, B, Döring, A, Kolcic, I, Zemunik, T, Boban, M, Minelli, C, Wheeler, H, Igl, W, Zaboli, G, Wild, S, Wright, A, Ellinghaus, D, Nöthlings, U, Jacobs, G, Biffar, R, Endlich, K, Ernst, F, Kroemer, H, Nauck, M, Stracke, S, Völzke, H, Aulchenko, Y, Polasek, O, Hastie, N, Vitart, V, Helmer, C, Wang, J, Ruggiero, D, Bergmann, S, Nikopensius, T, Province, M, Ketkar, S, Colhoun, H, Robino, A, Giulianini, F, Krämer, B, Portas, L, Ford, I, Buckley, B, Adam, M, Thun, G, Sala, C, Metzger, M, Mitchell, P, Ciullo, M, Kim, S, Gasparini, P, Pirastu, M, Jukema, J, Probst Hensch, N, Toniolo, D, Coresh, J, Schmidt, R, Kardia, S, Curhan, G, Gyllensten, U, Franke, A, Rettig, R, Parsa, A, Goessling, W, Kao, W, de Boer, I, Peralta, C, Akylbekova, E, Kramer, H, van der Harst, P, Arking, D, Franceschini, N, Hernandez, D, Townsend, R, Lumley, T, Kestenbaum, B, Haritunians, T, Waeber, G, Lu, X, Leak, T, Aasarød, K, Skorpen, F, Baumert, J, Devuyst, O, Mychaleckyj, J, Hallan, S, Navis, G, Shlipak, M, Bull, S, Paterson, A, Rotter, J, Beckmann, J, Dreisbach, A, Styrkarsdottir, U, Evangelou, E, Hsu, Y, Duncan, E, Ntzani, E, Oei, L, Albagha, O, Kemp, J, Koller, D, Minster, R, Vandenput, L, Willner, D, Xiao, S, Yerges Armstrong, L, Zheng, H, Alonso, N, Kammerer, C, Kaptoge, S, Leo, P, Wilson, S, Aalto, V, Alen, M, Aragaki, A, Center, J, Dailiana, Z, Duggan, D, Garcia Giralt, N, Giroux, S, Hocking, L, Husted, L, Jameson, K, Khusainova, R, Kim, G, Koromila, T, Kruk, M, Laaksonen, M, Lacroix, A, Lee, S, Leung, P, Lewis, J, Masi, L, Mencej Bedrac, S, Nguyen, T, Nogues, X, Patel, M, Prezelj, J, Scollen, S, Siggeirsdottir, K, Svensson, O, Trummer, O, van Schoor, N, Woo, J, Zhu, K, Balcells, S, Brandi, M, Cheng, S, Christiansen, C, Cooper, C, Frost, M, Goltzman, D, González Macías, J, Karlsson, M, Khusnutdinova, E, Koh, J, Kollia, P, Langdahl, B, Leslie, W, Lips, P, Ljunggren, Ö, Lorenc, R, Marc, J, Mellström, D, Obermayer Pietsch, B, Olmos, J, Pettersson Kymmer, U, Reid, D, Riancho, J, Rousseau, F, Tang, N, Urreizti, R, Van Hul, W, Zarrabeitia, M, Castano Betancourt, M, Herrera, L, Ingvarsson, T, Johannsdottir, H, Kwan, T, Li, R, Luben, R, Medina Gómez, C, Palsson, S, Reppe, S, Sigurdsson, G, van Meurs, J, Verlaan, D, Williams, F, Zhou, Y, Gautvik, K, Raychaudhuri, S, Cauley, J, Clark, G, Cummings, S, Danoy, P, Dennison, E, Eastell, R, Eisman, J, Jackson, R, Jones, G, Khaw, K, Mccloskey, E, Nandakumar, K, Peacock, M, Pols, H, Prince, R, Reid, I, Robbins, J, Sambrook, P, Sham, P, Tylavsky, F, Econs, M, Kung, A, Reeve, J, Streeten, E, Karasik, D, Ralston, S, Ioannidis, J, Kiel, D, Forsblom, C, Isakova, T, Mckay, G, Williams, W, Sadlier, D, Mäkinen, V, Swan, E, Boright, A, Ahlqvist, E, Keller, B, Huang, H, Ahola, A, Fagerholm, E, Gordin, D, Harjutsalo, V, He, B, Heikkilä, O, Hietala, K, Kytö, J, Lahermo, P, Lehto, M, Österholm, A, Parkkonen, M, Pitkäniemi, J, Rosengård Bärlund, M, Saraheimo, M, Sarti, C, Söderlund, J, Soro Paavonen, A, Syreeni, A, Thorn, L, Tikkanen, H, Tolonen, N, Tryggvason, K, Wadén, J, Gill, G, Prior, S, Guiducci, C, Mirel, D, Taylor, A, Hosseini, M, Parving, H, Rossing, P, Tarnow, L, Ladenvall, C, Alhenc Gelas, F, Lefebvre, P, Rigalleau, V, Roussel, R, Tregouet, D, Maestroni, A, Maestroni, S, Falhammar, H, Gu, T, Möllsten, A, Cimponeriu, D, Mihai, I, Mota, M, Mota, E, Serafinceanu, C, Stavarachi, M, Hanson, R, Nelson, R, Kretzler, M, Panduru, N, Gu, H, Brismar, K, Zerbini, G, Hadjadj, S, Marre, M, Lajer, M, Waggott, D, Savage, D, Bain, S, Martin, F, Godson, C, Groop, P, Maxwell, A, Sengupta, S, Peloso, G, Ganna, A, Mora, S, Chang, H, Den Hertog, H, Donnelly, L, Fraser, R, Freitag, D, Gurdasani, D, Kaakinen, M, Kettunen, J, Li, X, Montasser, M, Petersen, A, Saxena, R, Service, S, Sidore, C, Surakka, I, Van den Herik, E, Volcik, K, Asiki, G, Been, L, Bolton, J, Bonnycastle, L, Burnett, M, Cesana, G, Elliott, P, Eyjolfsson, G, Goodarzi, M, Gravito, M, Hartikainen, A, Hung, Y, Jones, M, Kaleebu, P, Kastelein, J, Kim, E, Komulainen, P, Lin, S, Nieminen, T, Nsubuga, R, Olafsson, I, Palotie, A, Papamarkou, T, Pomilla, C, Pouta, A, Ruokonen, A, Seeley, J, Silander, K, Stančáková, A, Tiret, L, van Pelt, L, Wainwright, N, Wijmenga, C, Willemsen, G, Young, E, Bennett, F, Boomsma, D, Bovet, P, Chen, Y, Feranil, A, Freimer, N, Hsiung, C, Järvelin, M, Kesäniemi, A, Koudstaal, P, Krauss, R, Kyvik, K, Martin, N, Meneton, P, Moilanen, L, Njølstad, I, Price, J, Sanghera, D, Sheu, W, Whitfield, J, Wolffenbuttel, B, Ordovas, J, Rich, S, Johnson, L, Larson, M, Levy, D, Newton Cheh, C, O'Reilly, P, Palmas, W, Rice, K, Snider, H, Tobin, M, Verwoert, G, Pihur, V, Heath, S, Sõber, S, Arora, P, Zhang, F, Lucas, G, Milaneschi, Y, Parker, A, Fava, C, Fox, E, Go, M, Sjögren, M, Vinay, D, Alexander, M, Tabara, Y, Shaw Hawkins, S, Whincup, P, Shi, G, Seielstad, M, Sim, X, Nguyen, K, Matullo, G, Gaunt, T, Onland Moret, N, Cooper, M, Platou, C, Org, E, Hardy, R, Dahgam, S, Palmen, J, Kuznetsova, T, Uiterwaal, C, Adeyemo, A, Ludwig, B, Tomaszewski, M, Tzoulaki, I, Palmer, N, Chang, Y, Steinle, N, Grobbee, D, Morrison, A, Najjar, S, Hadley, D, Connell, J, Day, I, Lawlor, D, Lawrence, R, Ongen, H, Li, Y, Young, J, Bis, J, Chaturvedi, N, Islam, M, Jafar, T, Kulkarni, S, Grässler, J, Howard, P, Guarrera, S, Ricceri, F, Emilsson, V, Plump, A, Weder, A, Sun, Y, Scott, L, Peltonen, L, Vartiainen, E, Brand, S, Wang, T, Burton, P, Artigas, M, Dong, Y, Wang, X, Zhu, H, Rudock, M, Heckbert, S, Smith, N, Wiggins, K, Doumatey, A, Shriner, D, Veldre, G, Viigimaa, M, Kinra, S, Prabhakaran, D, Tripathy, V, Langefeld, C, Rosengren, A, Thelle, D, Corsi, A, Singleton, A, Hilton, G, Salako, T, Iwai, N, Kita, Y, Ogihara, T, Ohkubo, T, Okamura, T, Ueshima, H, Umemura, S, Eyheramendy, S, Meitinger, T, Cho, Y, Scott, J, Sehmi, J, Hedblad, B, Nilsson, P, Stanèáková, A, Raffel, L, Yao, J, Schwartz, S, Ikram, M, Longstreth W., J, Mosley, T, Seshadri, S, Shrine, N, Wain, L, Morken, M, Laitinen, J, Zitting, P, Cooper, J, van Gilst, W, Janipalli, C, Mani, K, Yajnik, C, Mattace Raso, F, Lakatta, E, Orru, M, Scuteri, A, Ala Korpela, M, Kangas, A, Soininen, P, Tukiainen, T, Würtz, P, Ong, R, Galan, P, Hercberg, S, Lathrop, M, Zelenika, D, Zhai, G, Meschia, J, Sharma, P, Terzic, J, Kumar, M, Denniff, M, Zukowska Szczechowska, E, Wagenknecht, L, Fowkes, F, Charchar, F, Rotimi, C, Bots, M, Brand, E, Talmud, P, Nyberg, F, Laan, M, van der Schouw, Y, Casas, J, Vineis, P, Ganesh, S, Wong, T, Tai, E, Morris, R, Dominiczak, A, Marmot, M, Miki, T, Chandak, G, Zhu, X, Elosua, R, Soranzo, N, Sijbrands, E, Uda, M, Vasan, R, Anderson, C, Gordon, S, Guo, Q, Henders, A, Lambert, A, Kraft, P, Kennedy, S, Macgregor, S, Missmer, S, Painter, J, Roseman, F, Treloar, S, Wallace, L, Alizadeh, B, de Boer, R, Boezen, H, van der Klauw, M, Ormel, J, Postma, D, Rosmalen, J, Slaets, J, Lagou, V, Welch, R, Wheeler, E, Rehnberg, E, Lecoeur, C, Johnson, P, Hottenga, J, Salo, P, Bielak, L, Zhao, W, Horikoshi, M, Navarro, P, Chen, H, Rybin, D, Song, K, An, P, Marullo, L, Jansen, H, Edkins, S, Varga, T, Oksa, H, Antonella, M, Kong, A, Herder, C, Antti, J, Miljkovic, I, Atalay, M, Kiess, W, Smit, J, Campbell, S, Fowkes, G, Rathmann, W, Maerz, W, Watanabe, R, de Geus, E, Toenjes, A, Peyser, P, Körner, A, Cucca, F, Balkau, B, Bouatia Naji, N, Ahmadi, K, Ainali, C, Bataille, V, Bell, J, Buil, A, Dermitzakis, E, Dimas, A, Durbin, R, Glass, D, Hassanali, N, Hedman, Å, Ingle, C, Knowles, D, Krestyaninova, M, Lowe, C, Meduri, E, di Meglio, P, Montgomery, S, Nestle, F, Nica, A, Nisbet, J, O'Rahilly, S, Parts, L, Potter, S, Sekowska, M, Shin, S, Surdulescu, G, Travers, M, Tsaprouni, L, Tsoka, S, Wilk, A, Higashio, J, Williams, R, Nato, A, Ambite, J, Manolio, T, Hindorff, L, Heiss, G, Taylor, K, Avery, C, Graff, M, Lin, D, Quibrera, M, Cochran, B, Kao, L, Umans, J, Cole, S, Maccluer, J, Person, S, Gross, M, Fornage, M, Durda, P, Jenny, N, Patsy, B, Arnold, A, Buzkova, P, Haines, J, Murdock, D, Glenn, K, Brown Gentry, K, Thornton Wells, T, Dumitrescu, L, Jeff, J, Bush, W, Mitchell, S, Goodloe, R, Boston, J, Malinowski, J, Restrepo, N, Oetjens, M, Fowke, J, Zheng, W, Spencer, K, Pendergrass, S, Wilkens, L, Park, L, Tiirikainen, M, Kolonel, L, Lim, U, Cheng, I, Wang, H, Shohet, R, Stram, D, Henderson, B, Monroe, K, Schumacher, F, Anderson, G, Carlson, C, Prentice, R, Wu, C, Carty, C, Gong, J, Rosse, S, Young, A, Haessler, J, Kocarnik, J, Lin, Y, Kuller, L, He, C, Sulem, P, Barbalic, M, Broer, L, Byrne, E, Gudbjartsson, D, Mcardle, P, Porcu, E, van Wingerden, S, Zhuang, W, Lauc, L, Broekmans, F, Burri, A, Chanock, S, Chen, C, Corre, T, Coviello, A, D'Adamo, P, Davies, G, Deary, I, Ebrahim, S, Fauser, B, Ferreli, L, Folsom, A, Hall, P, Hankinson, S, Hass, M, Heath, A, Janssens, A, Keyzer, J, Lahti, J, Lai, S, Laisk, T, Laven, J, Liu, J, Lopez, L, Louwers, Y, Marongiu, M, Klaric, I, Masciullo, C, Medland, S, Melzer, D, Newman, A, Paré, G, Peeters, P, Pop, V, Räikkönen, K, Salumets, A, Smith, J, Stacey, S, Starr, J, Stathopoulou, M, Tenesa, A, Tryggvadottir, L, Tsui, K, van Dam, R, van Gils, C, van Nierop, P, Vink, J, Voorhuis, M, Wallaschofski, H, Widen, E, Wijnands van Gent, C, Zgaga, L, Zygmunt, M, Buring, J, Crisponi, L, Demerath, E, Murray, A, Visser, J, Lunetta, K, Elks, C, Cousminer, D, Feenstra, B, Lin, P, Smith, E, Warrington, N, Alavere, H, Berenson, G, Blackburn, H, Busonero, F, Chen, W, Easton, D, Foroud, T, Geller, F, Kilpeläinen, T, Li, S, Melbye, M, Murray, J, Murray, S, Ness, A, Northstone, K, Pennell, C, Pharoah, P, Rafnar, T, Rice, J, Ring, S, Schork, N, Segrè, A, Sovio, U, Srinivasan, S, Tammesoo, M, Tyrer, J, Weedon, M, Young, L, Bierut, L, Boyd, H, Psychiatry, NCA - Neurobiology of mental health, and EMGO - Lifestyle, overweight and diabetes
Subjects: Adipose Tissue/metabolism, Male, genetic association, subcutaneous fat, Transcription, Genetic, Adipocytes, Adipogenesis, Adipose Tissue, Age Factors, Body Mass Index, Continental Population Groups, Epigenesis, Genetic, Europe, Female, Genome, Human, Humans, Insulin, Insulin Resistance, Models, Biological, Neovascularization, Physiologic, Obesity, Polymorphism, Single Nucleotide, Quantitative Trait Loci, Sex Characteristics, Waist-Hip Ratio, Body Fat Distribution, Genome-Wide Association Study, Multidisciplinary, Insulin Resistance/genetics, Genome-wide association study, Continental Population Groups/genetics, genetic analysis, heritability, gene cluster, Science::Biological sciences::Human anatomy and physiology [DRNTU], 0302 clinical medicine, high density lipoprotein cholesterol, Models, genetics [Insulin Resistance], histone modification, Age Factor, insulin receptor, 0303 health sciences, Adipocyte, Human/genetics, CARDIOGRAMplusC4D Consortium, ADIPOGENIC DIFFERENTIATION, genetic correlation, body fat, Continental Population Group, priority journal, 5 trisphosphate 3 phosphatase, GEFOS Consortium, meta analysis (topic), Science & Technology - Other Topics, ddc:500, transcription regulation, Adipogenesis/genetics, Single Nucleotide/genetics, Human, medicine.medical_specialty, Waist, phosphatidylinositol 3, European, ta3111, genetic regulation, Article, developmental biology, 03 medical and health sciences, MAGIC Investigators, transcription initiation site, SDG 3 - Good Health and Well-being, Genetic, genomics, GLYCEMIC TRAITS, genetics [Continental Population Groups], Polymorphism, GENOME-WIDE ASSOCIATION, Physiologic, genetics [Adipogenesis], Adipocytes/metabolism, Europe/ethnology, Genome, Human/genetics, Insulin/metabolism, Neovascularization, Physiologic/genetics, Obesity/genetics, Polymorphism, Single Nucleotide/genetics, Quantitative Trait Loci/genetics, Transcription, Genetic/genetics, Genetic/genetics, Adipogenesi, Science & Technology, adiponectin, [ SDV ] Life Sciences [q-bio], vasculotropin, genetics [Quantitative Trait Loci], ta1184, Racial Groups, ta1182, gene mapping, ta3121, triacylglycerol blood level, medicine.disease, Biological, major clinical study, amino acid sequence, metabolism [Insulin], Endocrinology, metabolism [Adipocytes], genetic loci, insulin, body fat, GLGC, International Endogene Consortium, metabolism [Adipose Tissue], Body mass index, HUMAN HEIGHT, Epigenesis, LifeLines Cohort Study, ReproGen Consortium, BIO/12 - BIOCHIMICA CLINICA E BIOLOGIA MOLECOLARE CLINICA, tissue level, Physiologic/genetics, [SDV]Life Sciences [q-bio], Medizin, Adipose tissue, low density lipoprotein cholesterol, PAGE Consortium, COMMON SNPS, angiogenesis, Waist–hip ratio, genetics [Obesity], MESH: Adipocytes/metabolism Adipogenesis/genetics Adipose Tissue/metabolism* Age Factors Body Fat Distribution* Body Mass Index Continental Population Groups/genetics Epigenesis, Genetic Europe/ethnology Female Genome, Human/genetics Genome-Wide Association Study* Humans Insulin/metabolism* Insulin Resistance/genetics Male Models, Biological Neovascularization, Physiologic/genetics Obesity/genetics Polymorphism, Single Nucleotide/genetics Quantitative Trait Loci/genetics* Sex Characteristics Transcription, Genetic/genetics Waist-Hip Ratio, single nucleotide polymorphism, fat, genetic variability, molecular biology, body mass index (BMI), ethnology [Europe], peroxisome proliferator activated receptor, 2. Zero hunger, Genetics, Genome, Single Nucleotide, waist circumference, insulin, phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase, triacylglycerol, vasculotropin, developmental biology, gene expression, genome, numerical model, adipocyte, adipose tissue, body fat distribution, body mass, female, gene locus, gene structure, hip circumference, human, insulin resistance, lipoprotein blood level, male, obesity, protein protein interaction, sex difference, waist hip ratio, Multidisciplinary Sciences, genetics [Transcription, Genetic], genetics [Polymorphism, Single Nucleotide], ADIPOGen Consortium, genetics [Neovascularization, Physiologic], Transcription, SUSCEPTIBILITY LOCI, General Science & Technology, ICBP, 030209 endocrinology & metabolism, Biology, adipocyte, MESH : Adipocytes/metabolism Adipogenesis/genetics Adipose Tissue/metabolism* Age Factors Body Fat Distribution* Body Mass Index Continental Population Groups/genetics Epigenesis, Genetic Europe/ethnology Female Genome, Human/genetics Genome-Wide Association Study* Humans Insulin/metabolism* Insulin Resistance/genetics Male Models, Biological Neovascularization, Physiologic/genetics Obesity/genetics Polymorphism, Single Nucleotide/genetics Quantitative Trait Loci/genetics* Sex Characteristics Transcription, Genetic/genetics Waist-Hip Ratio, MESENCHYMAL STEM-CELLS, GENIE Consortium, SEXUAL-DIMORPHISM, Insulin resistance, Internal medicine, medicine, genetics [Genome, Human], ABDOMINAL ADIPOSITY, Neovascularization, 030304 developmental biology, FALSE DISCOVERY, CKDGen Consortium, Sex Characteristic, MuTHER Consortium, numerical model
Abstract: Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P
Published: 2015
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