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2. Application of Newly Customized Myeloid NGS Panel in the Diagnosis of Myeloid Malignancies

Author

Alkhatabi,Heba, Alqahtani,Wejdan, Alsolami,Reem, Elaimi,Aisha, Hazzazi,Mohannad, Almashjary,Majed, Alkhatabi,Hind, Alghuthami,Mohammad, Daous,Yara, Yasin,Elrashed, Barefah,Ahmed, Alkhatabi,Heba, Alqahtani,Wejdan, Alsolami,Reem, Elaimi,Aisha, Hazzazi,Mohannad, Almashjary,Majed, Alkhatabi,Hind, Alghuthami,Mohammad, Daous,Yara, Yasin,Elrashed, and Barefah,Ahmed

Abstract

Heba A Alkhatabi,1,2 Wejdan Alqahtani,3 Reem Alsolami,1,2 Aisha Elaimi,1,4 Mohannad S Hazzazi,1,2 Majed N Almashjary,1,2 Hind A Alkhatabi,5 Mohammad E Alghuthami,6 Yara M Daous,2,7 Elrashed B Yasin,8 Ahmed Barefah2,9 1Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, 22254, Saudi Arabia; 2Hematology Research Unit (HRU), King Fahad Medical Research Center, King Abdulaziz University, Jeddah, 22254, Saudi Arabia; 3Department of Medical Laboratory, King Abdulaziz University Hospital, Jeddah, Saudi Arabia; 4Center of Excellence in Genomic Medicine Research (CEGMR), King Abdulaziz University, Jeddah, 22254, Saudi Arabia; 5Department of Biochemistry, College of Science, University of Jeddah, Jeddah, 21589, Saudi Arabia; 6GCC Accreditation Center GAC, Jeddah, Saudi Arabia; 7Department of Pathology, Faculty of Medicine, King Abdulaziz University, Jeddah, 22254, Saudi Arabia; 8Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Rabigh, 25732, Saudi Arabia; 9Hematology Department, Faculty of Medicine, King Abdulaziz University, Jeddah, 21589, Saudi ArabiaCorrespondence: Elrashed B Yasin, Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Rabigh, 25732, Saudi Arabia, Tel +966 5 60910199, Email eyasin@kau.edu.saPurpose: Genetic mutations are major factors in the diagnosis and prognosis of leukemia, and it is difficult to assess these variants using single-gene analysis. Therefore, this study aimed to develop a fast and cost-effective method for genetic screening of myeloid malignancies using a customized next-generation sequencing (NGS) panel.Patients and Methods: A customized myeloid panel was designed and investigated in 15 acute myeloid leukemia patients. The panel included 11 genes that were most commonly mutated in myeloid malignancies. This panel was designed to sequence the complete genome of

Published
2024

5. Challenges of Human Papillomavirus Infection and Associated Diseases in Low-Resource Countries

Author

Nweke, Michael Chukwugoziem, Okolo, Clement Abu, Daous, Yara, and Esan, Olukemi Ayotunde

Subjects
Diagnosis, Complications and side effects, Research, Risk factors, Health aspects, Cervical cancer -- Risk factors -- Diagnosis, Prevalence studies (Epidemiology), Papillomavirus infections -- Complications and side effects -- Risk factors -- Diagnosis, Cancer research, Developing countries -- Health aspects, Health care services accessibility -- Research, Oncology, Experimental, Cancer -- Research
Abstract

Human papillomaviruses (HPVs) are DNA viruses that belong to the family Papillomaviridae with up to 150 subtypes sequenced. (1) They are the first known human tumor viruses associated with benign [...], * Context.--The prevalence of human papillomavirus (HPV) infection varies worldwide. The high-risk viruses are usually associated with cancers of the cervix, vagina, and vulva in women, cancer of the penis in men, and cancers of the anus, tonsils, oropharynx, and base of the tongue in both sexes. Objectives.--To review literature about the challenges and burden associated with HPV infection in low-resource (ie, developing) countries, focusing on sub-Saharan Africa. To review the prevention, incidence, prevalence, morbidity, and mortality of HPV infections in sub-Saharan Africa. To review the therapy and management of HPV infections in low-resource countries in comparison to developed countries. Data Sources.--Peer-reviewed literature and experience of some of the authors. Conclusions.--Sub-Saharan Africa has high HPV infection prevalence rates, with predominance of high-risk subtypes 16, 18, and 45. The difficulty of access to health care has led to higher morbidity and mortality related to HPV-related cancers. Improvement in screening programs will help in monitoring the spread of HPV infections. Survival studies can be more informative if reliable cancer registries are improved. HPV vaccination is not yet widely available and this may be the key to curtailing the spread of HPV infections in resource-poor countries. (Arch Pathol Lab Med. 2018;142:696-699; doi: 10.5858/arpa.2017-0565-RA)

Published
2018
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7. Acute myeloid leukemia with acute spinal cord compression as the first feature.

Author

Almohammadi, Abdullah, Bahashwan, Salem, Barefah, Ahmad, AlAhwal, Hatem, Radhwi, Osman, Barefah, Ghaith, and Daous, Yara

Subjects
THERAPEUTIC use of antineoplastic agents, FEVER, ANTHRACYCLINES, IMMUNOHISTOCHEMISTRY, MYELOID sarcoma, MAGNETIC resonance imaging, SURGICAL decompression, SPINAL stenosis, SHIVERING, TREATMENT effectiveness, WEIGHT loss, IMMUNOPHENOTYPING, BLOOD testing, CYTOGENETICS, CYTARABINE, SPINAL tumors, SPINAL cord compression, ACUTE diseases, PARAPLEGIA, NEEDLE biopsy, SYMPTOMS
Abstract

Malignant myeloid sarcoma (chloroma) is a rare extramedullary solid tumor that consists of immature myeloid precursor cells, constantly associated with acute myeloid leukemia (AML). Here, we report the case of a 35-year-old male who developed an acute paraplegia secondary to paraspinal chloroma associated with AML. A careful review of the patient's history, blood smear, and bone marrow findings will decrease the chance of missing the diagnosis. [ABSTRACT FROM AUTHOR]

Published
2023
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