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5. Targeting the gut to prevent and counteract metabolic disorders and pathologies during aging.

Author

Milenkovic, Dragan, Capel, Frédéric, Combaret, Lydie, Comte, Blandine, Dardevet, Dominique, Evrard, Bertrand, Guillet, Christelle, Monfoulet, Laurent-Emmanuel, Pinel, Alexandre, Polakof, Sergio, Pujos-Guillot, Estelle, Rémond, Didier, Wittrant, Yohann, and Savary-Auzeloux, Isabelle

Subjects
METABOLIC disorders, OLDER people, AGING, IMMUNITY, PATHOLOGY
Abstract

Impairment of gut function is one of the explanatory mechanisms of health status decline in elderly population. These impairments involve a decline in gut digestive physiology, metabolism and immune status, and associated to that, changes in composition and function of the microbiota it harbors. Continuous deteriorations are generally associated with the development of systemic dysregulations and ultimately pathologies that can worsen the initial health status of individuals. All these alterations observed at the gut level can then constitute a wide range of potential targets for development of nutritional strategies that can impact gut tissue or associated microbiota pattern. This can be key, in a preventive manner, to limit gut functionality decline, or in a curative way to help maintaining optimum nutrients bioavailability in a context on increased requirements, as frequently observed in pathological situations. The aim of this review is to give an overview on the alterations that can occur in the gut during aging and lead to the development of altered function in other tissues and organs, ultimately leading to the development of pathologies. Subsequently is discussed how nutritional strategies that target gut tissue and gut microbiota can help to avoid or delay the occurrence of aging-related pathologies. [ABSTRACT FROM AUTHOR]

Published
2023
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6. List of Contributors

Author

Aguirre, Leixuri, primary, Alemán-Mateo, Heliodoro, additional, Alway, Stephen E., additional, Antoun, Sami, additional, Arena, Ross, additional, Atkins, Janice L., additional, Bigard, Xavier, additional, Boirie, Yves, additional, Bond, Samantha, additional, Borghi Silva, Audrey, additional, Breuillard, Charlotte, additional, Capel, Frederic, additional, Cruzat, Vinicius F., additional, Dardevet, Dominique, additional, De Bandt, Jean-Pascal, additional, Domingues-Faria, Carla, additional, Farges, Marie-Chantal, additional, Fernández-Quintela, Alfredo, additional, Girgis, Christian M., additional, Gómez-Zorita, Saioa, additional, Goncalves-Mendes, Nicolas, additional, González, Marcela, additional, González-Arnay, Emilio, additional, González-Reimers, Emilio, additional, Gorissen, Stefan H.M., additional, Goron, Arthur, additional, Guillet, Christelle, additional, Handschin, Christoph, additional, Jeffries, Owen, additional, Le Bacquer, Olivier, additional, Margaritis, Irène, additional, Martín-González, Candelaria, additional, Mazzuco, Adriana, additional, Milton-Laskibar, Iñaki, additional, Moinard, Christophe, additional, Moro, Cedric, additional, Mosoni, Laurent, additional, Papet, Isabelle, additional, Patterson, Stephen D., additional, Pedersen, Bente K., additional, Pérez-Schindler, Joaquín, additional, Peyron, Marie-Agnès, additional, Phillips, Shane A., additional, Phillips, Stuart M., additional, Polakof, Sergio, additional, Portillo, Maria P., additional, Quintero-Platt, Geraldine, additional, Rémond, Didier, additional, Romero-Acevedo, Lucía, additional, Rossi, Andrea P., additional, Rubele, Sofia, additional, Ruiz Valenzuela, Roxana E., additional, Santolaria-Fernández, Francisco, additional, Savary-Auzeloux, Isabelle, additional, Scott, David, additional, Severin, Richard, additional, Smith, Gordon I., additional, Sorrentino, Matthew J., additional, Tachibana, Nobuhiko, additional, Waldron, Mark, additional, Walrand, Stéphane, additional, Wanezaki, Satoshi, additional, Yagasaki, Kazumi, additional, and Zamboni, Mauro, additional

Published
2019
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7. Sulfur Amino Acids and Skeletal Muscle

Author

Papet, Isabelle, primary, Rémond, Didier, additional, Dardevet, Dominique, additional, Mosoni, Laurent, additional, Polakof, Sergio, additional, Peyron, Marie-Agnès, additional, and Savary-Auzeloux, Isabelle, additional

Published
2019
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10. Data from Myostatin Gene Inactivation Prevents Skeletal Muscle Wasting in Cancer

Author

Gallot, Yann S., primary, Durieux, Anne-Cécile, primary, Castells, Josiane, primary, Desgeorges, Marine M., primary, Vernus, Barbara, primary, Plantureux, Léa, primary, Rémond, Didier, primary, Jahnke, Vanessa E., primary, Lefai, Etienne, primary, Dardevet, Dominique, primary, Nemoz, Georges, primary, Schaeffer, Laurent, primary, Bonnieu, Anne, primary, and Freyssenet, Damien G., primary

Published
2023
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11. Supplementary Materials and Methods from Myostatin Gene Inactivation Prevents Skeletal Muscle Wasting in Cancer

Author

Gallot, Yann S., primary, Durieux, Anne-Cécile, primary, Castells, Josiane, primary, Desgeorges, Marine M., primary, Vernus, Barbara, primary, Plantureux, Léa, primary, Rémond, Didier, primary, Jahnke, Vanessa E., primary, Lefai, Etienne, primary, Dardevet, Dominique, primary, Nemoz, Georges, primary, Schaeffer, Laurent, primary, Bonnieu, Anne, primary, and Freyssenet, Damien G., primary

Published
2023
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12. Supplementary Figure S4 from Myostatin Gene Inactivation Prevents Skeletal Muscle Wasting in Cancer

Author

Gallot, Yann S., primary, Durieux, Anne-Cécile, primary, Castells, Josiane, primary, Desgeorges, Marine M., primary, Vernus, Barbara, primary, Plantureux, Léa, primary, Rémond, Didier, primary, Jahnke, Vanessa E., primary, Lefai, Etienne, primary, Dardevet, Dominique, primary, Nemoz, Georges, primary, Schaeffer, Laurent, primary, Bonnieu, Anne, primary, and Freyssenet, Damien G., primary

Published
2023
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13. Supplementary Figure Legend from Myostatin Gene Inactivation Prevents Skeletal Muscle Wasting in Cancer

Author

Gallot, Yann S., primary, Durieux, Anne-Cécile, primary, Castells, Josiane, primary, Desgeorges, Marine M., primary, Vernus, Barbara, primary, Plantureux, Léa, primary, Rémond, Didier, primary, Jahnke, Vanessa E., primary, Lefai, Etienne, primary, Dardevet, Dominique, primary, Nemoz, Georges, primary, Schaeffer, Laurent, primary, Bonnieu, Anne, primary, and Freyssenet, Damien G., primary

Published
2023
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14. Supplementary Table S1 from Myostatin Gene Inactivation Prevents Skeletal Muscle Wasting in Cancer

Author

Gallot, Yann S., primary, Durieux, Anne-Cécile, primary, Castells, Josiane, primary, Desgeorges, Marine M., primary, Vernus, Barbara, primary, Plantureux, Léa, primary, Rémond, Didier, primary, Jahnke, Vanessa E., primary, Lefai, Etienne, primary, Dardevet, Dominique, primary, Nemoz, Georges, primary, Schaeffer, Laurent, primary, Bonnieu, Anne, primary, and Freyssenet, Damien G., primary

Published
2023
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17. How to optimize protein intake in aging population

Author

Dardevet, Dominique, Unité de Nutrition Humaine (UNH), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Clermont Auvergne (UCA), and S. Roland

Subjects
[SDV]Life Sciences [q-bio]
Abstract

International audience

Published
2023

18. With an AA intake identical to whey, a vegetable protein meal presents alterations in the arterial bioavailability of certain AAs in the elderly

Author

Dardevet, Dominique, Castro, Elena de Marco, Pratt, Jedd, Volkert, Dorothee, Mullen, Brian, Valli, Giacomo, Guillet, Christelle, Unité de Nutrition Humaine (UNH), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Clermont Auvergne (UCA), University College Dublin [Dublin] (UCD), Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), Département de Médecine (PADOVA - Médecine), Università degli Studi di Padova = University of Padua (Unipd), and Université Clermont Auvergne (UCA)

Subjects
[SDV]Life Sciences [q-bio]
Abstract

International audience

Published
2023

22. Peripheral Amino Acid Appearance Is Lower Following Plant Protein Fibre Products, Compared to Whey Protein and Fibre Ingestion, in Healthy Older Adults despite Optimised Amino Acid Profile

Author

de Marco Castro, Elena, primary, Valli, Giacomo, additional, Buffière, Caroline, additional, Guillet, Christelle, additional, Mullen, Brian, additional, Pratt, Jedd, additional, Horner, Katy, additional, Naumann-Gola, Susanne, additional, Bader-Mittermaier, Stephanie, additional, Paganini, Matteo, additional, De Vito, Giuseppe, additional, Roche, Helen M., additional, and Dardevet, Dominique, additional

Published
2022
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24. Identification par une approche de métabolomique des voies métaboliques associées à la fragilité dans une cohorte de personnes âgées

Author

Bougel, Céline, Servien, Rémi, Vialaneix, Nathalie, Canlet, Cécile, Debrauwer, Laurent, Demuth, Ilja, Norman, Kristina, Vetter, Valentin, Dardevet, Dominique, Polakof, Sergio, Unité de Nutrition Humaine (UNH), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Clermont Auvergne (UCA), Unité de Mathématiques et Informatique Appliquées de Toulouse (MIAT INRAE), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Laboratoire de Biotechnologie de l'Environnement [Narbonne] (LBE), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro Montpellier, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), ToxAlim (ToxAlim), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Ecole d'Ingénieurs de Purpan (INP - PURPAN), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], UNH Space Science Center [Durham] (SSC), University of New Hampshire (UNH), and Région Auvergne-Rhône-Alpes

Subjects
prévention, biomarqueurs, métabolisme, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Abstract

International audience

Published
2022

25. Anti-inflammatory Streptococcus thermophilus CNRZ160 limits sarcopenia induced by low-grade inflammation in older adult rats

Author

Savary-Auzeloux, Isabelle, Jarzaguet, Marianne, Migné, Carole, Kemeny, Jean-Louis, Novais-Gameiro, Lorraine, de Azevedo, Marcela, Mathé, Véronique, Mariotti, François, Langella, Philippe, Chatel, Jean-Marc, Dardevet, Dominique, Unité de Nutrition Humaine (UNH), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Clermont Auvergne (UCA), Physiologie de la Nutrition et du Comportement Alimentaire (PNCA (UMR 0914)), AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre Imagerie Cellulaire Santé (CICS), Université d'Auvergne - Clermont-Ferrand I (UdA)-Clermont Université, MICrobiologie de l'ALImentation au Service de la Santé (MICALIS), and The study was financed by Institut Carnot Qualiment, Agence Nationale pour la Recherche and INRAE.

Subjects
Nutrition and Dietetics, muscle, inflammation, Endocrinology, Diabetes and Metabolism, aging, gut, Streptococcus thermophilus, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, DSS, Food Science
Abstract

Background and aimsAging is characterized, at the systemic level, by the development of low-grade inflammation, which has been identified as determining sarcopenia by blunting postprandial muscle anabolism. The causes of this “inflammageing” is still not clearly defined. An increased intestinal permeability, a microbiota dysbiosis and subsequent generation of intestinal then generalized inflammation have been hypothesized. The objective of this study was to test in vivo during aging if (1) a chronic low-grade intestinal inflammation can lead to anabolic resistance and muscle loss and (2) if a bacterial strain presenting anti-inflammatory properties could prevent these adverse effects.MethodsYoung adult (6 m) and elderly rats (18 m) received Dextran Sodium Sulfate (DSS) for 28 days to generate low-grade intestinal inflammation, and received (PB1 or PB2 groups) or not (DSS group) one of the two S. Thermophilus strains (5 × 109 CFU/day) previously shown to present an anti-inflammatory potential in vitro. They were compared to pair fed control (PF). Muscle and colon weights and protein synthesis (using 13C Valine) were measured at slaughter. Muscle proteolysis, gut permeability and inflammatory markers were assessed only in old animals by RT-PCR or proteins quantifications (ELISA).ResultsIn both adult and old rats, DSS reduced absolute protein synthesis (ASR) in gastrocnemius muscle [−12.4% (PB1) and −9.5% (PB2) vs. PF, P < 0.05] and increased ASR in colon (+86% and +30.5%, respectively vs. PF, P < 0.05). PB1 (CNRZ160 strain) but not PB2 resulted in a higher muscle ASR as compared to DSS in adults (+18%, P < 0.05), a trend also observed for PB1 in old animals (+12%, P = 0.10). This was associated with a blunted increase in colon ASR. In old rats, PB1 also significantly decreased expression of markers of autophagy and ubiquitin-proteasome pathways vs. DSS groups and improved gut permeability (assessed by Occludin, Zonula Occludens 1 and Claudin 1 expression, P < 0.05) and alleviated systemic inflammation (A2M: −48% vs. DSS, P < 0.05).ConclusionThe loss of muscle anabolism associated with low-grade intestinal inflammation can be prevented by supplementation with anti-inflammatory CNRZ160 strain. We propose that the moderated gut inflammation by CNRZ160 may result in curtailed amino acids (AA) utilization by the gut, and subsequent restored AA systemic availability to support muscle protein accretion. Therefore, CNRZ160 could be considered as an efficient probiotic to modulate muscle mass loss and limit sarcopenia during aging.

Published
2022

29. Approaches to discern if microbiome associations reflect causation in metabolic and immune disorders

Author

Basic, Marijana, primary, Dardevet, Dominique, additional, Abuja, Peter Michael, additional, Bolsega, Silvia, additional, Bornes, Stéphanie, additional, Caesar, Robert, additional, Calabrese, Francesco Maria, additional, Collino, Massimo, additional, De Angelis, Maria, additional, Gérard, Philippe, additional, Gueimonde, Miguel, additional, Leulier, François, additional, Untersmayr, Eva, additional, Van Rymenant, Evelien, additional, De Vos, Paul, additional, and Savary-Auzeloux, Isabelle, additional

Published
2022
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30. Targeting the gut to prevent and counteract metabolic disorders and pathologies during aging

Author

Milenkovic, Dragan, primary, Capel, Frédéric, additional, Combaret, Lydie, additional, Comte, Blandine, additional, Dardevet, Dominique, additional, Evrard, Bertrand, additional, Guillet, Christelle, additional, Monfoulet, Laurent-Emmanuel, additional, Pinel, Alexandre, additional, Polakof, Sergio, additional, Pujos-Guillot, Estelle, additional, Rémond, Didier, additional, Wittrant, Yohann, additional, and Savary-Auzeloux, Isabelle, additional

Published
2022
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32. Approaches to discern if microbiome associations reflect causation in metabolic and immune disorders

Author

Joint Programming Initiative ‘A Healthy Diet for a Healthy Life’, German Research Foundation, European Commission, Federal Ministry of Education and Research (Germany), l’Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (France), Agence Nationale de la Recherche (France), Basic, Marijana, Dardevet, Dominique, Abuja, Peter Michael, Bolsega, Silvia Bolsega, Bornes, Stéphanie, Caesar, Robert, Calabrese, Francesco Maria, Collino, Massimo, Angelis, Maria de, Gérard, Philippe, Gueimonde Fernández, Miguel, Leulier, François, Untersmayr, Eva, Rymenantl, Evelien van, Vos, Paul de, Savary-Auzeloux, Isabelle, Joint Programming Initiative ‘A Healthy Diet for a Healthy Life’, German Research Foundation, European Commission, Federal Ministry of Education and Research (Germany), l’Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (France), Agence Nationale de la Recherche (France), Basic, Marijana, Dardevet, Dominique, Abuja, Peter Michael, Bolsega, Silvia Bolsega, Bornes, Stéphanie, Caesar, Robert, Calabrese, Francesco Maria, Collino, Massimo, Angelis, Maria de, Gérard, Philippe, Gueimonde Fernández, Miguel, Leulier, François, Untersmayr, Eva, Rymenantl, Evelien van, Vos, Paul de, and Savary-Auzeloux, Isabelle

Abstract

Our understanding of microorganisms residing within our gut and their roles in the host metabolism and immunity advanced greatly over the past 20 years. Currently, microbiome studies are shifting from association and correlation studies to studies demonstrating causality of identified microbiome signatures and identification of molecular mechanisms underlying these interactions. This transformation is crucial for the efficient translation into clinical application and development of targeted strategies to beneficially modulate the intestinal microbiota. As mechanistic studies are still quite challenging to perform in humans, the causal role of microbiota is frequently evaluated in animal models that need to be appropriately selected. Here, we provide a comprehensive overview on approaches that can be applied in addressing causality of host-microbe interactions in five major animal model organisms (Caenorhabditis elegans, Drosophila melanogaster, zebrafish, rodents, and pigs). We particularly focused on discussing methods available for studying the causality ranging from the usage of gut microbiota transfer, diverse models of metabolic and immune perturbations involving nutritional and chemical factors, gene modifications and surgically induced models, metabolite profiling up to culture-based approached. Furthermore, we addressed the impact of the gut morphology, physiology as well as diet on the microbiota composition in various models and resulting species specificities. Finally, we conclude this review with the discussion on models that can be applied to study the causal role of the gut microbiota in the context of metabolic syndrome and host immunity. We hope this review will facilitate important considerations for appropriate animal model selection.

Published
2022

36. Postprandial Responses on Serum Metabolome to Milk and Yogurt Intake in Young and Older Men

Author

Kim, Jinyoung, primary, Blaser, Carola, additional, Portmann, Reto, additional, Badertscher, René, additional, Marmonier, Corinne, additional, Blot, Adeline, additional, David, Jérémie, additional, Stoffers, Helena, additional, von Ah, Ueli, additional, Bütikofer, Ueli, additional, Vergères, Guy, additional, Dardevet, Dominique, additional, and Polakof, Sergio, additional

Published
2022
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39. A Mix of Dietary Fibres Changes Interorgan Nutrients Exchanges and Muscle-Adipose Energy Handling in Overfed Mini-Pigs

Author

Mohamed, Ahmed Ben, Remond, Didier, Gual-Grau, Andreu, Bernalier-Donnadille, Annick, Capel, Frédéric, Michalski, Marie-Caroline, Laugerette, Fabienne, Cohade, Benoit, Hafnaoui, Noureddine, Béchet, Daniel, Coudy-Gandilhon, Cécile, Gueugneau, Marine, Salles, Jérôme, Migné, Carole, Dardevet, Dominique, David, Jérémie, Polakof, Sergio, Savary-Auzeloux, Isabelle, Unité de Nutrition Humaine (UNH), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Clermont Auvergne (UCA), Microbiologie Environnement Digestif Santé (MEDIS), Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and ROSSI, Sabine

Subjects
Dietary Fiber, obesity, Swine, dietary fibres, muscle metabolism, Incretins, Article, Feces, Overnutrition, overfeeding, Animals, Urea, TX341-641, Lactic Acid, Amino Acids, Muscle, Skeletal, Nutrition. Foods and food supply, métabolisme inter-organes, digestive, oral, and skin physiology, fibres alimentaires, food and beverages, Bread, inter-organ metabolism, Fatty Acids, Volatile, SCFA, Intestines, l'expression du gène, [SDV.AEN] Life Sciences [q-bio]/Food and Nutrition, Disease Models, Animal, obésité, suralimentation, Glucose, Adipose Tissue, Dietary Supplements, gene expression, Swine, Miniature, Female, Fermented Foods, Energy Metabolism, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, métabolisme musculaire
Abstract

This study evaluates the capacity of a bread enriched with fermentable dietary fibres to modulate the metabolism and nutrients handling between tissues, gut and peripheral, in a context of overfeeding. Net fluxes of glucose, lactate, urea, short chain fatty acids (SCFA), and amino acids were recorded in control and overfed female mini-pigs supplemented or not with fibre-enriched bread. SCFA in fecal water and gene expressions, but not protein levels or metabolic fluxes, were measured in muscle, adipose tissue, and intestine. Fibre supplementation increased the potential for fatty acid oxidation and mitochondrial activity in muscle (acox, ucp2, sdha and cpt1-m, p < 0.05) as well as main regulatory transcription factors of metabolic activity such as pparα, pgc-1α and nrf2. All these features were associated with a reduced muscle fibre cross sectional area, resembling to controls (i.e., lean phenotype). SCFA may be direct inducers of these cross-talk alterations, as their feces content (+52%, p = 0.05) was increased in fibre-supplemented mini-pigs. The SCFA effects could be mediated at the gut level by an increased production of incretins (increased gcg mRNA, p < 0.05) and an up-regulation of SCFA receptors (increased gpr41 mRNA, p < 0.01). Hence, consumption of supplemented bread with fermentable fibres can be an appropriate strategy to activate muscle energy catabolism and limit the establishment of an obese phenotype.

Published
2021

41. Bactéries probiotiques issues d’un patient souffrant du syndrome de grêle court : une stratégie prometteuse pour réduire la sarcopénie chez les personnes âgées sous-alimentées

Author

Muriel, Giron, Thomas, Muriel, Bornes, Stéphanie, Jarzaguet, Marianne, Mayeur, Camille, Dardevet, Dominique, Chassard, Christophe, Savary-Auzeloux, Isabelle, Unité de Nutrition Humaine (UNH), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Clermont Auvergne (UCA), Unité Mixte de Recherche sur le Fromage (UMRF), VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Clermont Auvergne (UCA), MICrobiologie de l'ALImentation au Service de la Santé (MICALIS), AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and Giron, Muriel

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2021

42. Peripheral Amino Acid Appearance Is Lower Following Plant Protein Fibre Products, Compared to Whey Protein and Fibre Ingestion, in Healthy Older Adults despite Optimised Amino Acid Profile.

Author

de Marco Castro, Elena, Valli, Giacomo, Buffière, Caroline, Guillet, Christelle, Mullen, Brian, Pratt, Jedd, Horner, Katy, Naumann-Gola, Susanne, Bader-Mittermaier, Stephanie, Paganini, Matteo, De Vito, Giuseppe, Roche, Helen M., and Dardevet, Dominique

Abstract

Plant-based proteins are generally characterised by lower Indispensable Amino Acid (IAA) content, digestibility, and anabolic properties, compared to animal-based proteins. However, they are environmentally friendlier, and wider consumption is advocated. Older adults have higher dietary protein needs to prevent sarcopenia, a disease marked by an accelerated loss of muscle mass and function. Given the lower environmental footprint of plant-based proteins and the importance of optimising dietary protein quality among older adults, this paper aims to assess the net peripheral Amino Acid (AA) appearance after ingestion of three different plant protein and fibre (PPF) products, compared to whey protein with added fibre (WPF), in healthy older adults. In a randomised, single-blind, crossover design, nine healthy men and women aged ≥65 years consumed four test meals balanced in AA according to the FAO reference protein for humans, matched for leucine, to optimally stimulate muscle protein synthesis in older adults. A fasted blood sample was drawn at each visit before consuming the test meal, followed by postprandial arterialise blood sampling every 30 min for 3 h. The test meal was composed of a soup containing either WPF or PPF 1–3. The PPF blends comprised pea proteins with varying additional rice, pumpkin, soy, oat, and/or almond protein. PPF product ingestion resulted in a lower maximal increase of postprandial leucine concentration and the sum of branched-chain AA (BCAA) and IAA concentrations, compared to WPF, with no effect on their incremental area under the curve. Plasma methionine and cysteine, and to a lesser extent threonine, appearance were limited after consuming the PPF products, but not WPF. Despite equal leucine doses, the WPF induced greater postprandial insulin concentrations than the PPF products. In conclusion, the postprandial appearance of AA is highly dependent on the protein source in older adults, despite providing equivalent IAA levels and dietary fibre. Coupled with lower insulin concentrations, this could imply less anabolic potential. Further investigation is required to understand the applicability of plant-based proteins in healthy older adults. [ABSTRACT FROM AUTHOR]

Published
2023
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45. Innovative plAnt Protein fibre and Physical activity solutions to address poor appEtite and prevenT undernutrITion in oldEr adults – APPETITE

Author

Volkert, Dorothee, primary, Corish, Clare A., additional, Dardevet, Dominique, additional, De Vito, Giuseppe, additional, Guillet, Christelle, additional, Bader‐Mittermaier, Stephanie, additional, Robinson, Sian, additional, Roche, Helen M., additional, Sayer, Avan A., additional, and Visser, Marjolein, additional

Published
2021
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48. A bread enriched in fermentable fibers increases lipids oxidation in muscles and protects liver from lipid accumulation in overfed mini pig

Author

Ben Ahmed, Mohamed, Remond, Didier, Bernalier-Donadille, Annick, Capel, Frédéric, Cohade, Benoit, Hafnaoui, Noureddine, Bechet, Daniel, Coudy-Gandilhon, Cecile, Dardevet, Dominique, Migné, Carole, David, Jérémie, Saulnier, Luc, Della Valle, Guy, Polakof, Sergio, Savary-Auzeloux, Isabelle, Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Unité de Nutrition Humaine (UNH), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Clermont Auvergne (UCA), Microbiologie Environnement Digestif Santé (MEDIS), Unité de recherche sur les Biopolymères, Interactions Assemblages (BIA), and Savary-Auzeloux, Isabelle

Subjects
[SDV.AEN] Life Sciences [q-bio]/Food and Nutrition, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2021

49. Microbiota and Metabolite Modifications after Dietary Exclusion of Dairy Products and Reduced Consumption of Fermented Food in Young and Older Men

Author

Kim, Jinyoung, primary, Burton-Pimentel, Kathryn J., additional, Fleuti, Charlotte, additional, Blaser, Carola, additional, Scherz, Valentin, additional, Badertscher, René, additional, Marmonier, Corinne, additional, Lyon-Belgy, Noëlle, additional, Caille, Aurélie, additional, Pidou, Véronique, additional, Blot, Adeline, additional, Bertelli, Claire, additional, David, Jérémie, additional, Bütikofer, Ueli, additional, Greub, Gilbert, additional, Dardevet, Dominique, additional, Polakof, Sergio, additional, and Vergères, Guy, additional

Published
2021
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