30 results on '"Darley S"'
Search Results
2. Where next for people with cognitive disabilities and\ud electronic assistive technology?
- Author
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Clarke, Z, Darley, S, Wright, A, Surridge, J, Martindale, A, Simmons, B, Hunnisett, S, and Dukas, T
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- 2021
3. Improving methods and procedures for reuse and exchange of open educational resources
- Author
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Patrick McAndrew, Wilson, T., Darley, S., Malone, S., and O Hare, D.
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- 2009
4. Importância do Método Situacional para o ensino dos Esportes Coletivos
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Marília Suzy Ferreira de Queiroz, Darley Severino Cardoso, Raphaella Christine Ribeiro de Lima, and Iberê Caldas Souza Leão
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esporte ,metodologia ,método situacional ,aprendizagem ,cognição ,Sports ,GV557-1198.995 - Abstract
O método situacional (MS) tem sido eficaz para o desenvolvimento da capacidade tática e técnica dos atletas, estimulando processos cognitivos como: percepção, tomada de decisão, aprendizagem, entre outros. Objetivou-se identificar e discutir a utilização do MS e sua importância para aprendizagem dos esportes coletivos (EC). O estudo trata-se de uma revisão de literatura, onde se utilizou as bases de dados: Bireme, Pubmed e Scielo. Selecionaram-se estudos em português e inglês, utilizando os termos: esporte coletivo, métodos de ensino, método situacional e ensino do esporte. Após identificar e discutir a importância do MS para aprendizagem dos EC identificou-se que este é um modo eficaz para o desenvolvimento do processo de ensino aprendizagem e treinamento. Faz-se necessária aprendizagem de todos os métodos de ensino, e aprofundar o conhecimento concernente ao MS; sua aplicabilidade propiciará um entendimento maior do jogo e, consequentemente, aumento da eficácia do atleta.
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- 2021
5. What Drives Participation in State Voluntary Cleanup Programs? Evidence from Oregon
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Blackman, A., primary, Darley, S., additional, Lyon, T. P., additional, and Wernstedt, K., additional
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- 2010
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6. Short report: endomyocardial fibrosis and cardiomyopathy in an area endemic for schistosomiasis
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José Roberto Lambertucci, Darley S. Marques, Joel Alves Lamounier, Edmundo Clarindo Oliveira, Marcia M. Barbosa, and Mara V. Souza
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Adult ,Male ,medicine.medical_specialty ,Pathology ,Adolescent ,Heart disease ,Endomyocardial fibrosis ,Cardiomyopathy ,Helminthiasis ,Schistosomiasis ,Electrocardiography ,Feces ,Fibrosis ,Virology ,Internal medicine ,Abdomen ,Humans ,Medicine ,cardiovascular diseases ,Child ,Endocardium ,Aged ,medicine.diagnostic_test ,business.industry ,Middle Aged ,Endomyocardial Fibrosis ,medicine.disease ,Echocardiography, Doppler ,Infectious Diseases ,Child, Preschool ,cardiovascular system ,Cardiology ,Female ,Parasitology ,Cardiomyopathies ,business ,circulatory and respiratory physiology - Abstract
An association of schistosomiasis and endomyocardial fibrosis or cardiomyopathy has been suggested. Clinical, stool, abdominal ultrasound, electrocardiogram, and Doppler echocardiogram examinations were performed on 226 patients from an area endemic for schistosomiasis. The diagnosis of schistosomiasis was made in 152 patients (69%) but clinical, electrocardiographic, or Doppler echocardiographic evidence of a schistosome cardiomyopathy or endomyocardial fibrosis could not be detected in any patient.
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- 1998
7. Pulmonary hypertension in schistosomiasis mansoni
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Barbosa, Marcia M., primary, Lamounier, Joel A., additional, Oliveira, Edmundo C., additional, Souza, Mara V., additional, Marques, Darley S., additional, Silva, Arnaldo A., additional, and Lambertucci, JoséR., additional
- Published
- 1996
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8. Heart rate changes in children as a function of test versus game instructions and test anxiety.
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Darley, Susan A., Katz, Irwin, Darley, S A, and Katz, I
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HEART beat ,PATIENT monitoring ,HEART rate monitoring ,CHANGE ,CHILDREN ,ANXIETY - Abstract
20 fifth- grade boys were individually given a quantitative estimations task while their cardiac responses were being continuously recorded. In the first part of the task all subjects received game instructions, and in the second part half received game instructions and half received test instructions. Upon completing the task, subjects filled out the Test Anxiety Scale for Children (TASC). It was found that heart rate accelerated after test instructions and decelerated after game instructions. These results augmented by a pattern of marginally significant, p < .11, correlations support the view that heart rate acceleration following test instructions reflected increased task motivation, and deceleration following game instructions reflected decreased task motivation, or relaxation. In general, the data tend to demonstrate the usefulness of using cardiac indices for studying test behavior and anxiety in children. [ABSTRACT FROM AUTHOR]
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- 1973
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9. O narrador e a paisagem: Milton Hatoum, Bernardo Carvalho e o fim do projeto de uma literatura nacional
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Pedro Dolabela Chagas and Dárley Suany Leite dos Santos
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national literature ,novel ,milton hatoum ,bernardo carvalho ,French literature - Italian literature - Spanish literature - Portuguese literature ,PQ1-3999 - Abstract
In this paper, we discuss the end of the project of a national literature a s a guiding project of the Brazilian novel, having in mind the changes in the construction of the narrator and the representation of natural and social landscapes. To characterize such conditions, we review Echevarría’s proposition that the 19th - century La tin American novel adopted the local landscape as an identity symbol under the interpretive and authoritative mediation of non -fictional discourse. Then, we analyze Süssekind’s characterizations of fictional narrators that consolidated that function in Bra zil until the 20th century. In contrast, in Hatoum’s and Carvalho’s works, the multiplication of voices, the fragmentation of truths and the self - observation of the narrator block the mobilization of the landscape for an identity - function, in a deviation o f the founding assumptions of a national literature which indicates its demise as a common project – an important historical transition for the Brazilian novel.
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- 2015
10. Improving methods and procedures for reuse and exchange of open educational resources
- Author
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McAndrew, P., Wilson, T., Darley, S., Malone, S., O'Hare, D., McAndrew, P., Wilson, T., Darley, S., Malone, S., and O'Hare, D.
11. Improving methods and procedures for reuse and exchange of open educational resources
- Author
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McAndrew, P., Wilson, T., Darley, S., Malone, S., O'Hare, D., McAndrew, P., Wilson, T., Darley, S., Malone, S., and O'Hare, D.
12. Infectious Pancreatic Necrosis: Experimental Induction of a Carrier State in Trout
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Reno, P. W., primary, Darley, S., additional, and Savan, M., additional
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- 1978
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13. Patient experiences of an online consultation system: a qualitative study in English primary care post-COVID-19.
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Moschogianis S, Darley S, Coulson T, Peek N, Cheraghi-Sohi S, and Brown BC
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- Humans, Male, Female, England, Middle Aged, Adult, Patient Satisfaction, Physician-Patient Relations, Pandemics, Aged, General Practice, COVID-19 epidemiology, Qualitative Research, SARS-CoV-2, Remote Consultation, Primary Health Care
- Abstract
Background: Online consultation systems (OCSs) allow patients to contact their healthcare teams online. Since 2020 they have been rapidly rolled out in primary care following policy initiatives and the COVID-19 pandemic. In-depth research of patients' experiences using OCSs is lacking., Aim: Explore patients' experiences of using an OCS., Design and Setting: Qualitative study in English GP practices using the Patchs OCS (www.Patchs.ai) from March 2020 to July 2022., Method: Thematic analysis of 25 patient interviews and 21 467 written comments from 11 851 patients who used the OCS from nine and 240 GP practices, respectively., Results: Patients cited benefits of using the OCS as speed, flexibility, and efficiency. Nevertheless, some patients desired a return to traditional consultation methods. GP practices often did not clearly advertise the OCS or use it as patients expected, which caused frustration. Patients reported advantages of having a written record of consultations and the opportunity to communicate detailed queries in free text. Views differed on how the OCS influenced clinical safety and discussions of sensitive topics. Patients who struggled to communicate in traditional consultations often preferred using the OCS, and male patients reported being more likely to use it., Conclusion: Globally, this is the largest in-depth study of patient experiences of an OCS. It contributes new knowledge that the patient experience of using OCSs can be influenced by previously unreported patient characteristics and the conditions they consult about. Further, it contributes recommendations on the design and implementation of the OCS in practice., (© The Authors.)
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- 2024
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14. "Attending to History" in Major System Change in Healthcare in England: Specialist Cancer Surgery Service Reconfiguration.
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Perry C, Boaden RJ, Black GB, Clarke CS, Darley S, Ramsay AIG, Shackley DC, Vindrola-Padros C, and Fulop NJ
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- Humans, England, Health Facilities, Qualitative Research, Leadership, Delivery of Health Care, Neoplasms therapy
- Abstract
Background: The reconfiguration of specialist hospital services, with service provision concentrated in a reduced number of sites, is one example of major system change (MSC) for which there is evidence of improved patient outcomes. This paper explores the reconfiguration of specialist oesophago-gastric (OG) cancer surgery services in a large urban area of England (Greater Manchester, GM), with a focus on the role of history in this change process and how reconfiguration was achieved after previous failed attempts., Methods: This study draws on qualitative research from a mixed-methods evaluation of the reconfiguration of specialist cancer surgery services in GM. Forty-six interviews with relevant stakeholders were carried out, along with ~160 hours of observations at meetings and the acquisition of ~300 pertinent documents. Thematic analysis using deductive and inductive approaches was undertaken, guided by a framework of 'simple rules' for MSC., Results: Through an awareness of, and attention to, history, leaders developed a change process which took into account previous unsuccessful reconfiguration attempts, enabling them to reduce the impact of potentially challenging issues. Interviewees described attending to issues involving competition between provider sites, change leadership, engagement with stakeholders, and the need for a process of change resilient to challenge., Conclusion: Recognition of, and response to, history, using a range of perspectives, enabled this reconfiguration. Particularly important was the way in which history influenced and informed other aspects of the change process and the influence of stakeholder power. This study provides further learning about MSC and the need for a range of perspectives to enable understanding. It shows how learning from history can be used to enable successful change., (© 2022 The Author(s); Published by Kerman University of Medical Sciences This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.)
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- 2022
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15. Understanding How the Design and Implementation of Online Consultations Affect Primary Care Quality: Systematic Review of Evidence With Recommendations for Designers, Providers, and Researchers.
- Author
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Darley S, Coulson T, Peek N, Moschogianis S, van der Veer SN, Wong DC, and Brown BC
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- United States, Humans, Female, Male, Pandemics, Artificial Intelligence, Referral and Consultation, Quality of Health Care, COVID-19
- Abstract
Background: Online consultations (OCs) allow patients to contact their care providers on the web. Worldwide, OCs have been rolled out in primary care rapidly owing to policy initiatives and COVID-19. There is a lack of evidence regarding how OC design and implementation influence care quality., Objective: We aimed to synthesize research on the impacts of OCs on primary care quality, and how these are influenced by system design and implementation., Methods: We searched databases from January 2010 to February 2022. We included quantitative and qualitative studies of real-world OC use in primary care. Quantitative data were transformed into qualitative themes. We used thematic synthesis informed by the Institute of Medicine domains of health care quality, and framework analysis informed by the nonadoption, abandonment, scale-up, spread, and sustainability framework. Strength of evidence was judged using the GRADE-CERQual approach., Results: We synthesized 63 studies from 9 countries covering 31 OC systems, 14 (22%) of which used artificial intelligence; 41% (26/63) of studies were published from 2020 onward, and 17% (11/63) were published after the COVID-19 pandemic. There was no quantitative evidence for negative impacts of OCs on patient safety, and qualitative studies suggested varied perceptions of their safety. Some participants believed OCs improved safety, particularly when patients could describe their queries using free text. Staff workload decreased when sufficient resources were allocated to implement OCs and patients used them for simple problems or could describe their queries using free text. Staff workload increased when OCs were not integrated with other software or organizational workflows and patients used them for complex queries. OC systems that required patients to describe their queries using multiple-choice questionnaires increased workload for patients and staff. Health costs decreased when patients used OCs for simple queries and increased when patients used them for complex queries. Patients using OCs were more likely to be female, younger, and native speakers, with higher socioeconomic status. OCs increased primary care access for patients with mental health conditions, verbal communication difficulties, and barriers to attending in-person appointments. Access also increased by providing a timely response to patients' queries. Patient satisfaction increased when using OCs owing to better primary care access, although it decreased when using multiple-choice questionnaire formats., Conclusions: This is the first theoretically informed synthesis of research on OCs in primary care and includes studies conducted during the COVID-19 pandemic. It contributes new knowledge that, in addition to having positive impacts on care quality such as increased access, OCs also have negative impacts such as increased workload. Negative impacts can be mitigated through appropriate OC system design (eg, free text format), incorporation of advanced technologies (eg, artificial intelligence), and integration into technical infrastructure (eg, software) and organizational workflows (eg, timely responses)., Trial Registration: PROSPERO CRD42020191802; https://tinyurl.com/2p84ezjy., (©Sarah Darley, Tessa Coulson, Niels Peek, Susan Moschogianis, Sabine N van der Veer, David C Wong, Benjamin C Brown. Originally published in the Journal of Medical Internet Research (https://www.jmir.org), 24.10.2022.)
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- 2022
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16. Contributors are representative, as long as they agree: How confirmation logic overrides effort to achieve synthesis in applied health research.
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Knowles SE, Walkington P, Flynn J, Darley S, Boaden R, and Kislov R
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- Humans, Qualitative Research, Surveys and Questionnaires, Logic, Research Personnel, Patient Participation
- Abstract
Introduction: The paradox of representation in public involvement in research is well recognized, whereby public contributors are seen as either too naïve to meaningfully contribute or too knowledgeable to represent 'the average patient'. Given the underlying assumption that expertise undermines contributions made, more expert contributors who have significant experience in research can be a primary target of criticism. We conducted a secondary analysis of a case of expert involvement and a case of lived experience, to examine how representation was discussed in each., Methods: We analysed a case of a Lived Experience Advisory Panel (LEAP) chosen for direct personal experience of a topic and a case of an expert Patient and Public Involvement (PPI) panel. Secondary analysis was of multiple qualitative data sources, including interviews with the LEAP contributors and researchers, Panel evaluation data and documentary analysis of researcher reports of Panel impacts. Analysis was undertaken collaboratively by the author team of contributors and researchers., Results: Data both from interviews with researchers and reported observations by the Panel indicated that representation was a concern for researchers in both cases. Consistent with previous research, this challenge was deployed in response to contributors requesting changes to researcher plans. However, we also observed that when contributor input could be used to support research activity, it was described unequivocally as representative of 'the patient view'. We describe this as researchers holding a confirmation logic. By contrast, contributor accounts enacted a synthesis logic, which emphasized multiplicity of viewpoints and active dialogue. These logics are incompatible in practice, with the confirmation logic constraining the potential for the synthesis logic to be achieved., Conclusion: Researchers tend to enact a confirmation logic that seeks a monophonic patient voice to legitimize decisions. Contributors are therefore limited in their ability to realize a synthesis logic that would actively blend different types of knowledge. These different logics hold different implications regarding representation, with the synthesis logic emphasizing diversity and negotiation, as opposed to the current system in which 'being representative' is a quality attributed to contributors by researchers., Patient or Public Contribution: Patient contributors are study coauthors, partners in analysis and reporting., (© 2022 The Authors. Health Expectations published by John Wiley & Sons Ltd.)
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- 2022
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17. Organising Support for Carers of Stroke Survivors (OSCARSS): a cluster randomised controlled trial with economic evaluation.
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Patchwood E, Woodward-Nutt K, Rhodes SA, Batistatou E, Camacho E, Knowles S, Darley S, Grande G, Ewing G, and Bowen A
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- Adult, Cost-Benefit Analysis, Humans, Quality of Life, Surveys and Questionnaires, Survivors, Caregivers, Stroke
- Abstract
Objective: Investigated clinical effectiveness and cost-effectiveness of a person-centred intervention for informal carers/caregivers of stroke survivors., Design: Pragmatic cluster randomised controlled trial (cRCT) with economic and process evaluation., Setting: Clusters were services, from a UK voluntary sector specialist provider, delivering support primarily in the homes of stroke survivors and informal carers., Participants: Adult carers in participating clusters were referred to the study by cluster staff following initial support contact., Interventions: Intervention was the Carer Support Needs Assessment Tool for Stroke: a staff-facilitated, carer-led approach to help identify, prioritise and address the specific support needs of carers. It required at least one face-to-face support contact dedicated to carers, with reviews as required. Control was usual care, which included carer support (unstructured and variable)., Outcome Measures: Participants provided study entry and self-reported outcome data by postal questionnaires, 3 and 6 months after first contact by cluster staff., Primary Outcome: 3-month caregiver strain (Family Appraisal of Caregiving Questionnaire, FACQ)., Secondary Outcomes: FACQ subscales of caregiver distress and positive appraisals of caregiving, mood (Hospital Anxiety and Depression Scale) and satisfaction with stroke services (Pound). The economic evaluation included self-reported healthcare utilisation, intervention costs and EQ-5D-5L., Randomisation and Masking: Clusters were recruited before randomisation to intervention or control, with stratification for size of service. Cluster staff could not be masked as training was required for participation. Carer research participants provided self-reported outcome data unaware of allocation; they consented to follow-up data collection only., Results: Between 1 February 2017 and 31 July 2018, 35 randomised clusters (18 intervention; 17 control) recruited 414 cRCT carers (208 intervention; 206 control). Study entry characteristics were well balanced., Primary Outcome Measure: intention-to-treat analysis for 84% retained participants (175 intervention; 174 control) found mean (SD) FACQ carer strain at 3 months to be 3.11 (0.87) in the control group compared with 3.03 (0.90) in the intervention group, adjusted mean difference of -0.04 (95% CI -0.20 to 0.13). Secondary outcomes had similarly small differences and tight CIs. Sensitivity analyses suggested robust findings. Intervention fidelity was not achieved. Intervention-related group costs were marginally higher with no additional health benefit observed on EQ-5D-5L. No adverse events were related to the intervention., Conclusions: The intervention was not fully implemented in this pragmatic trial. As delivered, it conferred no clinical benefits and is unlikely to be cost-effective compared with usual care from a stroke specialist provider organisation. It remains unclear how best to support carers of stroke survivors. To overcome the implementation challenges of person-centred care in carers' research and service development, staff training and organisational support would need to be enhanced., Trial Registration Number: ISRCTN58414120., Competing Interests: Competing interests: AB, GG, SAR, EB and GE held grants with NIHR during the course of the OSCARSS Study. AB and EP additionally hold grants with Stroke Association outside of this work. There are no other relationships or activities that could appear to have influenced the submitted work., (© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
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- 2021
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18. Challenges implementing a carer support intervention within a national stroke organisation: findings from the process evaluation of the OSCARSS trial.
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Darley S, Knowles S, Woodward-Nutt K, Mitchell C, Grande G, Ewing G, Rhodes S, Bowen A, and Patchwood E
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- Humans, Needs Assessment, Surveys and Questionnaires, Survivors, Caregivers, Stroke therapy
- Abstract
Objectives: To examine the implementation of an intervention to support informal caregivers and to help understand findings from the Organising Support for Carers of Stroke Survivors (OSCARSS) cluster randomised controlled trial (cRCT)., Design: Longitudinal process evaluation using mixed methods. Normalisation process theory informed data collection and provided a sensitising framework for analysis., Setting: Specialist stroke support services delivered primarily in the homes of informal carers of stroke survivors., Participants: OSCARSS cRCT participants including carers, staff, managers and senior leaders., Intervention: The Carer Support Needs Assessment Tool for Stroke (CSNAT-Stroke) intervention is a staff-facilitated, carer-led approach to help identify, prioritise and address support needs., Results: We conducted qualitative interviews with: OSCARSS cRCT carer participants (11 intervention, 10 control), staff (12 intervention, 8 control) and managers and senior leaders (11); and obtained 140 responses to an online staff survey over three separate time points. Both individual (carer/staff) and organisational factors impacted implementation of the CSNAT-Stroke intervention and how it was received by carers. We identified four themes: staff understanding, carer participation, implementation, and learning and support. Staff valued the idea of a structured approach to supporting carers, but key elements of the intervention were not routinely delivered. Carers did not necessarily identify as 'carers', which made it difficult for staff to engage them in the intervention. Despite organisational enthusiasm for OSCARSS, staff in the intervention arm perceived support and training for implementation of CSNAT-Stroke as delivered primarily by the research team, with few opportunities for shared learning across the organisation., Conclusions: We identified challenges across carer, staff and organisation levels that help explain the OSCARSS cRCT outcome. Ensuring training is translated into practice and ongoing organisational support would be required for full implementation of this type of intervention, with emphasis on the carer-led aspects, including supporting carer self-identification., Trial Registration Number: ISRCTN58414120., Competing Interests: Competing interests: GG reports grants from NIHR CLAHRC, during the conduct of the study; In addition, GG has a patent Copyright issued. GE reports grants from NIHR, during the conduct of the study; In addition, GE has a patent Copyright issued. SR reports grants from NIHR, during the conduct of the study. AB reports grants from NIHR, grants from Stroke Association, during the conduct of the study; grants from Stroke Association, grants from NIHR, outside the submitted work. EP reports grants from Stroke Association, outside the submitted work. SD, SK, KW-N and CM have nothing to disclose., (© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ.)
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- 2021
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19. Implementing major system change in specialist cancer surgery: The role of provider networks.
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Vindrola-Padros C, Ramsay AI, Perry C, Darley S, Wood VJ, Clarke CS, Hines J, Levermore C, Melnychuk M, Moore CM, Morris S, Mughal MM, Pritchard-Jones K, Shackley D, and Fulop NJ
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- Delivery of Health Care, Humans, London, Leadership, Neoplasms
- Abstract
Objective: Major system change (MSC) has multiple, sometimes conflicting, goals and involves implementing change across a number of organizations. This study sought to develop new understanding of how the role that networks can play in implementing MSC, using the case of centralization of specialist cancer surgery in London, UK., Methods: The study was based on a framework drawn from literature on networks and MSC. We analysed 100 documents, conducted 134 h of observations during relevant meetings and 81 interviews with stakeholders involved in the centralization. We analysed the data using thematic analysis., Results: MSC in specialist cancer services was a contested process, which required constancy in network leadership over several years, and its horizontal and vertical distribution across the network. A core central team composed of network leaders, managers and clinical/manager hybrid roles was tasked with implementing the changes. This team developed different forms of engagement with provider organizations and other stakeholders. Some actors across the network, including clinicians and patients, questioned the rationale for the changes, the clinical evidence used to support the case for change, and the ways in which the changes were implemented., Conclusions: Our study provides new understanding of MSC by discussing the strategies used by a provider network to facilitate complex changes in a health care context in the absence of a system-wide authority.
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- 2021
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20. The impact of a combinatorial digital and organisational intervention on the management of long-term conditions in UK primary care: a non-randomised evaluation.
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Lugo-Palacios DG, Hammond J, Allen T, Darley S, McDonald R, Blakeman T, and Bower P
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- England, Facilities and Services Utilization, Hospitalization statistics & numerical data, Humans, Long-Term Care standards, Patient Acceptance of Health Care statistics & numerical data, Primary Health Care organization & administration, Primary Health Care standards, Program Evaluation, Quality Improvement, Telemedicine statistics & numerical data, Chronic Disease therapy, Long-Term Care organization & administration
- Abstract
Background: Better management of long-term conditions remains a policy priority, with a focus on improving outcomes and reducing use of expensive hospital services. A number of interventions have been tested, but many have failed to show benefit in rigorous comparative research. In 2016, the NHS Test Beds scheme was launched to implement and test interventions combining digital technologies and pathway redesign in routine health care settings, with each intervention comprising multiple innovations to better realise benefit from their 'combinatorial' effect. We present the evaluation of one of the NHS Test Beds, which combined risk stratification algorithms, practice-based quality improvement and health monitoring and coaching to improve management of long-term conditions in a single health economy in the north-west of England., Methods: The NHS Test Bed was implemented in one clinical commissioning group in the north-west of England (patient population 235,800 served by 36 general practices). Routine administrative data on hospital use (the primary outcome) and a selection of secondary outcomes (data from both hospital and primary care) were collected in the intervention site, and from a comparator area in the same region. We used difference-in-differences analysis to compare outcomes in the NHS Test Bed area and the comparator after initiation of the combinatorial intervention., Results: Tests confirmed the existence of parallel trends in the intervention and comparator sites for hospital outcomes for the period April 2016 to March 2017, and for some of the planned primary care outcomes. Based on 10 months of post-intervention secondary care data and 13 months post-intervention primary care data, we found no significant impact on primary outcomes between the intervention and comparator site, and a significant impact on only one secondary outcome., Conclusion: A combinatorial digital and organisational intervention to improve the management of long-term conditions was implemented across a whole health economy, but we found no evidence of a positive impact on health care utilisation outcomes in hospital and primary care.
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- 2019
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21. Improvement capability and performance: a qualitative study of maternity services providers in the UK.
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Darley S, Walshe K, Boaden R, Proudlove N, and Goff M
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- Female, Hospital Administration methods, Humans, Personnel, Hospital, Pregnancy, Qualitative Research, Quality of Health Care organization & administration, United Kingdom, Maternal Health Services standards, Quality Improvement organization & administration, Quality of Health Care standards
- Abstract
Objective: We explore variations in service performance and quality improvement across healthcare organisations using the concept of improvement capability. We draw upon a theoretically informed framework comprising eight dimensions of improvement capability, firstly to describe and compare quality improvement within healthcare organisations and, secondly to investigate the interactions between organisational performance and improvement capability., Design: A multiple qualitative case study using semi-structured interviews guided by the improvement capability framework., Setting: Five National Health Service maternity services sites across the UK. We focused on maternity services due to high levels of variation in quality and the availability of performance metrics which enabled us to select organisations from across the performance spectrum., Participants: About 52 hospital staff members across the five case studies in positions relevant to the research questions, including midwives, obstetricians and clinical managers/leaders., Main Outcome Measure: A qualitative analysis of narratives of quality improvement and performance in the five case studies, using the improvement capability framework as an analytic device to compare and contrast cases., Results: The improvement capability framework has utility in analysing quality improvement within and across organisations. Qualitative differences in the configurations of improvement capability were identified across all providers but were particularly striking between higher and lower performing organisations., Conclusions: The improvement capability framework is a useful tool for healthcare organisations to assess, manage and develop their own improvement capabilities. We identified an interaction between performance and improvement capability; higher performing organisations appeared to have more developed improvement capabilities, though the meaning of this relationship requires further research.
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- 2018
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22. Three week loading for the Baha BI-300® implant system.
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Wazen JJ, Daugherty J, Darley S, and Wycherly B
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- Aged, Bone Conduction physiology, Cochlear Implantation adverse effects, Feasibility Studies, Female, Follow-Up Studies, Hearing Loss, Sensorineural diagnosis, Humans, Male, Middle Aged, Prospective Studies, Prosthesis Design, Tertiary Care Centers, Time Factors, Treatment Outcome, Cochlear Implantation methods, Cochlear Implants, Hearing Loss, Sensorineural surgery, Osseointegration physiology
- Abstract
Purpose: The timing of loading of titanium craniofacial implants is dependent upon implant characteristics, host factors, and the bonding of titanium oxide and bone referred to as osseointegration. The purpose of this feasibility study seeks to determine the safety of early loading of the Baha BI-300 implant system (Cochlear Limited, Englewood, CO), which has been modified with novel surface texture and geometric design., Subjects and Methods: This prospective study measures implant stability as determined by clinical evaluation and resonance frequency analysis at implantation and at 1, 3, 6, 12, 24 and 52weeks post-op in 20 patients who underwent single-stage implantation and exteriorization of the BI-300. The processor was loaded at 3weeks post-operatively. A modified Holger's classification system was used to evaluate skin reactions., Results: There was a positive linear trend in mean implant stability scores from implantation to 52weeks. Only one subject (5%) had a mild local soft tissue Holger's grade 1 score at 24weeks. No implant loss or postoperative complications were encountered as a result of the 3-week loading., Conclusion: Three-week loading of the BI-300 implant did not result in any implant loss or failure of osseointegration. Earlier activation of the external processor with earlier hearing rehabilitation resulted in improved patient satisfaction. Further studies are needed to confirm these results for more universal adoption of early loading in adults., (Copyright © 2015 Elsevier Inc. All rights reserved.)
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- 2015
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23. Prereferral rectal artesunate for treatment of severe childhood malaria: a cost-effectiveness analysis.
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Tozan Y, Klein EY, Darley S, Panicker R, Laxminarayan R, and Breman JG
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- Administration, Rectal, Africa, Artesunate, Child, Preschool, Cost-Benefit Analysis, Health Services Accessibility, Humans, Infant, Infant, Newborn, Referral and Consultation, Rural Population, Time Factors, Antimalarials administration & dosage, Antimalarials economics, Artemisinins administration & dosage, Artemisinins economics, Malaria drug therapy, Malaria economics
- Abstract
Background: Severely ill patients with malaria with vomiting, prostration, and altered consciousness cannot be treated orally and need injections. In rural areas, access to health facilities that provide parenteral antimalarial treatment is poor. Safe and effective treatment of most severe malaria cases is delayed or not achieved. Rectal artesunate interrupts disease progression by rapidly reducing parasite density, but should be followed by further antimalarial treatment. We estimated the cost-effectiveness of community-based prereferral artesunate treatment of children suspected to have severe malaria in areas with poor access to formal health care., Methods: We assessed the cost-effectiveness (in international dollars) of the intervention from the provider perspective. We studied a cohort of 1000 newborn babies until 5 years of age. The analysis assessed how the cost-effectiveness results changed with low (25%), moderate (50%), high (75%), and full (100%) referral compliance and intervention uptake., Findings: At low intervention uptake and referral compliance (25%), the intervention was estimated to avert 19 disability-adjusted life-years (DALYs; 95% CI 16-21) and to cost I$1173 (95% CI 1050-1297) per DALY averted. Under the full uptake and compliance scenario (100%), the intervention could avert 967 DALYs (884-1050) at a cost of I$77 (73-81) per DALY averted., Interpretation: Prereferral artesunate treatment is a cost-effective, life-saving intervention, which can substantially improve the management of severe childhood malaria in rural African settings in which programmes for community health workers are in place., Funding: The Disease Control Priorities Project; Fogarty International Center; US National Institutes of Health; and the Peter Paul Career Development Professorship, Boston University., (Copyright © 2010 Elsevier Ltd. All rights reserved.)
- Published
- 2010
- Full Text
- View/download PDF
24. Cost-effectiveness projections of single and combination therapies for visceral leishmaniasis in Bihar, India.
- Author
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Olliaro P, Darley S, Laxminarayan R, and Sundar S
- Subjects
- Adolescent, Adult, Amphotericin B economics, Antiprotozoal Agents economics, Child, Cost-Benefit Analysis, Direct Service Costs, Drug Administration Schedule, Drug Costs, Female, Hospital Costs, Humans, India, Leishmaniasis, Visceral economics, Leishmaniasis, Visceral mortality, Male, Paromomycin economics, Phosphorylcholine administration & dosage, Phosphorylcholine economics, Practice Guidelines as Topic, Young Adult, Amphotericin B administration & dosage, Antiprotozoal Agents administration & dosage, Leishmaniasis, Visceral drug therapy, Paromomycin administration & dosage, Phosphorylcholine analogs & derivatives
- Abstract
Objectives: To assess the cost-effectiveness of current monotherapies and prospective combinations for treating visceral leishmaniasis (VL) in Bihar, India in terms of years of life lost (YLL) averted as well as deaths averted., Methods: We employed two methods to estimate the number of avertable deaths in our analysis: one using estimated mortality, the other using direct incidence estimates for VL. Costs of care are based on an average private hospital in Bihar, and data on drug costs were obtained both locally and from the World Health Organization., Results: The cost of monotherapies per averted YLL ranged from US$2 for paromomycin in an outpatient setting to US$20-22 for AmBisome at 20 mg/kg. The corresponding costs per death averted ranged from US$53-54 to US$523-527. Combinations ranged US$5-8 per YLL averted and US$124-213 per death averted., Conclusion: The available treatments for VL are cost-effective, and our mortality and incidence-based methods produce consistent estimates. The combinations considered here were more cost-effective than most monotherapies. Having multiple treatment options and combining drugs are also likely to reduce drug pressure and prolong the drugs' life-span of effective use.
- Published
- 2009
- Full Text
- View/download PDF
25. Global investments in TB control: economic benefits.
- Author
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Laxminarayan R, Klein EY, Darley S, and Adeyi O
- Subjects
- Africa South of the Sahara epidemiology, Cost-Benefit Analysis, Humans, Tuberculosis economics, Tuberculosis mortality, Directly Observed Therapy economics, Health Care Costs, Tuberculosis prevention & control
- Abstract
The Global Plan to Stop TB calls for significant financial resources to meet the Millennium Development Goals for tuberculosis. However, it is unclear whether the economic benefits of TB control exceed the costs. Using an epidemiological model, we find that the economic benefits of the Global Plan relative to sustained DOTS (a commonly used treatment method) were unambiguously greater than the incremental costs in all nine high-burden countries in Africa and in Afghanistan, Pakistan, and Russia. Benefit-cost ratios of sustaining DOTS at current levels relative to having no DOTS exceeded 1 in all twenty-two high-burden, TB-endemic countries and sub-Saharan Africa.
- Published
- 2009
- Full Text
- View/download PDF
26. Down memory lane: a laborious trek.
- Author
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Darley S
- Subjects
- Aviation, Female, Humans, Infant, Newborn, Male, Pregnancy, Zambia, Midwifery
- Published
- 1980
27. Treatment of severe malnutrition in relief.
- Author
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Mason JB, Hay RW, Leresche J, Peel S, and Darley S
- Subjects
- Animals, Blood Proteins analysis, Body Height, Body Weight, Child, Child Nutritional Physiological Phenomena, Child Welfare, Edema therapy, Ethiopia, Humans, Kwashiorkor therapy, Nutrition Disorders blood, Nutrition Disorders diagnosis, Regional Medical Programs, Diet Therapy, Disasters, Milk, Nutrition Disorders therapy
- Published
- 1974
- Full Text
- View/download PDF
28. The story of vitamin D: from vitamin to hormone.
- Author
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Mason JB, Hay RW, Leresche J, Peel S, and Darley S
- Subjects
- Animals, Bone and Bones metabolism, Calcium metabolism, Cell Nucleus metabolism, Cells drug effects, History, 20th Century, Intestinal Absorption drug effects, Intestines cytology, Kidney cytology, Molecular Conformation, Protein Biosynthesis, RNA, Messenger pharmacology, Rabbits, Cholecalciferol biosynthesis, Disasters, Ergocalciferols isolation & purification, Hydroxycholecalciferols isolation & purification, Hydroxycholecalciferols therapeutic use, Vitamin D analysis, Vitamin D biosynthesis, Vitamin D metabolism, Vitamin D pharmacology, Vitamin D physiology
- Published
- 1974
29. A study of two species of fish inoculated with spruce budworm nuclear polyhedrosis virus.
- Author
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Savan M, Budd J, Reno PW, and Darley S
- Subjects
- Animals, Fishes, Insect Viruses, Trout, Virus Diseases etiology, Fish Diseases etiology, Virus Diseases veterinary
- Abstract
Preliminary studies conducted on rainbow trout (Salmo gairdneri) and white suckers (Castostomus commersoni) exposed to spruce budworm nuclear polyhedrosis virus revealed minor histopathologic changes in various organs of each fish which were interpreted as not being significant. However, an evaluation (mean values) of the total changes in groups of fish suggested that a relationship may exist in the suckers exposed to either purified polyhedra or virions. A more extensive and definitive study must be done before any conclusions are warranted.
- Published
- 1979
- Full Text
- View/download PDF
30. Fear-provoking recommendations, intentions to take preventive actions, and actual preventive actions.
- Author
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Krisher HP 3rd, Darley SA, and Darley JM
- Subjects
- Arousal, Attitude to Health, Cognition, Feedback, Heart Rate, Humans, MMPI, Male, Mumps, Mumps Vaccine, Personality, Self Concept, Vaccination, Attitude, Communication, Fear
- Published
- 1973
- Full Text
- View/download PDF
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