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2. Use of immune repertoire sequencing to resolve discordant microscopic and immunochemical findings in a case of T cell-rich large B cell lymphoma in a young dog

Author

Lee, Gary Kwok Cheong, Bienzle, Dorothee, Keller, Stefan Matthias, Hwang, Mei-Hua, Darzentas, Nikos, Chang, Haiyang, Rätsep, Emily, Egan, Rebecca, and Beeler-Marfisi, Janet

Subjects
Cancer, Digestive Diseases, Liver Disease, Lymphoma, Rare Diseases, Hematology, 2.1 Biological and endogenous factors, Aetiology, Inflammatory and immune system, Animals, Antigens, CD, Ascites, Dog Diseases, Dogs, Euthanasia, Animal, Flow Cytometry, Immunohistochemistry, Immunophenotyping, Liver Neoplasms, Lymphocyte Subsets, Lymphoma, Large B-Cell, Diffuse, Male, T-Lymphocytes, Canine, Clonality, Flow cytometry, Liver, Neoplasia, Next-generation sequencing, PCR for antigen receptor gene rearrangements, TCRBL, Immunocytochemistry, Biochemistry and Cell Biology, Microbiology, Veterinary Sciences
Abstract

BackgroundLymphocytic neoplasms with frequent reactive lymphocytes are uncommonly reported in dogs, and can pose a diagnostic challenge. Different diagnostic modalities such as cytology, flow cytometry, histopathology, immunohistochemistry, and clonality testing, are sometimes required for a diagnosis. This report illustrates the value of using a multi-modal diagnostic approach to decipher a complex lymphocytic tumor, and introduces immune repertoire sequencing as a diagnostic adjunct.Case presentationA 10-month-old Great Dane was referred for marked ascites. Cytologic analysis of abdominal fluid and hepatic aspirates revealed a mixed lymphocyte population including numerous large lymphocytes, yielding a diagnosis of lymphoma. Flow cytometrically, abdominal fluid lymphocytes were highly positive for CD4, CD5, CD18, CD45, and MHC II, consistent with T cell lymphoma. Due to a rapidly deteriorating clinical condition, the dog was euthanized. Post mortem histologic evaluation showed effacement of the liver by aggregates of B cells surrounded by T cells, suggestive of hepatic T cell-rich large B cell lymphoma. Immune repertoire sequencing confirmed the presence of clonal B cells in the liver but not the abdominal fluid, whereas reactive T cells with shared, polyclonal immune repertoires were found in both locations.ConclusionsT cell-rich large B cell lymphoma is a rare neoplasm in dogs that may be challenging to diagnose and classify due to mixed lymphocyte populations. In this case, the results of histopathology, immunohistochemistry and immune repertoire sequencing were most consistent with a hepatic B cell neoplasm and reactive T cells exfoliating into the abdominal fluid. Immune repertoire sequencing was helpful in delineating neoplastic from reactive lymphocytes and characterizing repertoire overlap in both compartments. The potential pitfalls of equating atypical cytomorphology and monotypic marker expression in neoplasia are highlighted.

Published
2021

3. Topology and expressed repertoire of the Felis catus T cell receptor loci.

Author

Radtanakatikanon, Araya, Keller, Stefan M, Darzentas, Nikos, Moore, Peter F, Folch, Géraldine, Nguefack Ngoune, Viviane, Lefranc, Marie-Paule, and Vernau, William

Subjects
Lymphoid Tissue, Animals, Cats, Humans, Receptors, Antigen, T-Cell, Genomics, Phylogeny, Amino Acid Sequence, Sequence Homology, Amino Acid, Genetic Loci, Adaptive Immunity, High-Throughput Nucleotide Sequencing, Expressed repertoire, Feline, T cell receptor, TRA/TRD, TRB, TRG, V/J usage, Biotechnology, Genetics, Aetiology, 2.1 Biological and endogenous factors, TRA, TRD, V, J usage, Biological Sciences, Information and Computing Sciences, Medical and Health Sciences, Bioinformatics
Abstract

BACKGROUND:The domestic cat (Felis catus) is an important companion animal and is used as a large animal model for human disease. However, the comprehensive study of adaptive immunity in this species is hampered by the lack of data on lymphocyte antigen receptor genes and usage. The objectives of this study were to annotate the feline T cell receptor (TR) loci and to characterize the expressed repertoire in lymphoid organs of normal cats using high-throughput sequencing. RESULTS:The Felis catus TRG locus contains 30 genes: 12 TRGV, 12 TRGJ and 6 TRGC, the TRB locus contains 48 genes: 33 TRBV, 2 TRBD, 11 TRBJ, 2 TRBC, the TRD locus contains 19 genes: 11 TRDV, 2 TRDD, 5 TRDJ, 1 TRDC, and the TRA locus contains 127 genes: 62 TRAV, 64 TRAJ, 1 TRAC. Functional feline V genes form monophyletic clades with their orthologs, and clustering of multimember subgroups frequently occurs in V genes located at the 5' end of TR loci. Recombination signal (RS) sequences of the heptamer and nonamer of functional V and J genes are highly conserved. Analysis of the TRG expressed repertoire showed preferential intra-cassette over inter-cassette rearrangements and dominant usage of the TRGV2-1 and TRGJ1-2 genes. The usage of TRBV genes showed minor bias but TRBJ genes of the second J-C-cluster were more commonly rearranged than TRBJ genes of the first cluster. The TRA/TRD V genes almost exclusively rearranged to J genes within their locus. The TRAV/TRAJ gene usage was relatively balanced while the TRD repertoire was dominated by TRDJ3. CONCLUSIONS:This is the first description of all TR loci in the cat. The genomic organization of feline TR loci was similar to that of previously described jawed vertebrates (gnathostomata) and is compatible with the birth-and-death model of evolution. The large-scale characterization of feline TR genes provides comprehensive baseline data on immune repertoires in healthy cats and will facilitate the development of improved reagents for the diagnosis of lymphoproliferative diseases in cats. In addition, these data might benefit studies using cats as a large animal model for human disease.

Published
2020

4. Composite lymphoma of concurrent T zone lymphoma and large cell B cell lymphoma in a dog

Author

Matsuyama, Arata, Bienzle, Dorothee, Richardson, Danielle, Deravi, Nariman, Hwang, Mei-Hua, Darzentas, Nikos, and Keller, Stefan M

Subjects
Veterinary Sciences, Agricultural, Veterinary and Food Sciences, Biological Sciences, Microbiology, Genetics, Cancer, Hematology, Rare Diseases, Human Genome, Lymphoma, Animals, Antineoplastic Agents, Alkylating, Antineoplastic Agents, Hormonal, Chlorambucil, Dog Diseases, Dogs, Lymphoma, Large B-Cell, Diffuse, Lymphoma, T-Cell, Male, Prednisone, Canine, Clonality, Dog, Lymphosarcoma, Antigen receptor gene rearrangement, PARR, Composite lymphoma, Biochemistry and Cell Biology, Veterinary sciences
Abstract

BackgroundEvolution of indolent to aggressive lymphoma has been described in dogs but is difficult to distinguish from the de novo development of a second, clonally distinct lymphoma. Differentiation of these scenarios can be aided by next generation sequencing (NGS)-based assessment of clonality of lymphocyte antigen receptor genes.Case presentationAn 8-year-old male intact Mastiff presented with generalized lymphadenomegaly was diagnosed with nodal T zone lymphoma (TZL) based on cytology, histopathology, immunohistochemistry and flow cytometry. Thirteen months later, the dog re-presented with progressive lymphadenomegaly, and based on cytology and flow cytometry, a large B cell lymphoma (LBCL) was diagnosed. Sequencing-based clonality testing confirmed the de novo development of a LBCL and the persistence of a TZL.ConclusionsThe occurrence of two distinct lymphoid neoplasms should be considered if patient features and tumor cytomorphology or immunophenotype differ among sequential samples. Sequencing-based clonality testing may provide conclusive evidence of two concurrent and distinct clonal lymphocyte populations, termed most appropriately "composite lymphoma".

Published
2019

5. EuroClonality-NGS recommendations for evaluation of B cell clonality analysis by next-generation sequencing – a structured approach with the DEPART algorithm

Author

van den Brand, Michiel, Mobs, Markus, Otto, Franziska, Kroeze, Leonie I., Castro, David Gonzalez-de, Stamatopoulos, Kostas, Davi, Frederic, Bravetti, Clotilde, Kolijn, P. Martijn, Vlachonika, Elisavet, Stewart, J Peter, Pott, Christiane, Hummel, Michael, Darzentas, Nikos, Langerak, Anton W., Fend, Falko, and Groenen, Patricia JTA.

Published
2023
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6. Comprehensive genetic analysis by targeted sequencing identifies risk factors and predicts patient outcome in Mantle Cell Lymphoma: results from the EU-MCL network trials

Author

Pott, Christiane, primary, Khouja, Mouhamad, additional, Jiang, Linmiao, additional, Pal, Karol, additional, Stewart, James, additional, Regmi, Binaya, additional, Schwarz, Martin, additional, Klapper, Wolfram, additional, Alig, Stefan, additional, Darzentas, Nikos, additional, Kluin-Nelemans, Hanneke, additional, Hermine, Olivier, additional, Dreyling, Martin, additional, Gonzalez, David, additional, and Hoster, Eva, additional

Published
2024
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12. Validation of the EuroClonality-NGS DNA capture panel as an integrated genomic tool for lymphoproliferative disorders

Author

Stewart, James Peter, Gazdova, Jana, Darzentas, Nikos, Wren, Dörte, Proszek, Paula, Fazio, Grazia, Songia, Simona, Alcoceba, Miguel, Sarasquete, Maria Eugenia, Villarese, Patrick, van der Klift, Michèle Y., Heezen, Kim C., McCafferty, Neil, Pal, Karol, Catherwood, Mark, Kim, Chang Sik, Srivastava, Shambhavi, Kroeze, Leonie I., Hodges, Elizabeth, Stamatopoulos, Kostas, Klapper, Wolfram, Genuardi, Elisa, Ferrero, Simone, van den Brand, Michiel, Cazzaniga, Giovanni, Davi, Frederic, Sutton, Lesley-Ann, Garcia-Sanz, Ramon, Groenen, Patricia J.T.A., Macintyre, Elizabeth A., Brüggemann, Monika, Pott, Christiane, Langerak, Anton W., and Gonzalez, David

Published
2021
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13. Genetic drivers in the natural history of chronic lymphocytic leukemia development as early as 16 years before diagnosis

Author

Kolijn, P. Martijn, primary, Späth, Florentin, additional, Khouja, Mouhamad, additional, Hengeveld, Paul J., additional, van der Straten, Lina, additional, Darzentas, Nikos, additional, Hultdin, Magnus, additional, McKay, James D., additional, Pott, Christiane, additional, Vermeulen, Roel C. H., additional, and Langerak, Anton W., additional

Published
2023
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15. Dominant T-cell Receptor Delta Rearrangements in B-cell Precursor Acute Lymphoblastic Leukemia: Leukemic Markers or Physiological γδ T Repertoire?

Author

Kelm, Miriam, primary, Darzentas, Franziska, additional, Darzentas, Nikos, additional, Kotrova, Michaela, additional, Wessels, Wiebke, additional, Bendig, Sonja, additional, Baldus, Claudia D., additional, Lettau, Marcus, additional, Gökbuget, Nicola, additional, Kabelitz, Dieter, additional, Brüggemann, Monika, additional, and Chitadze, Guranda, additional

Published
2023
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16. P601: GENETIC DRIVERS IN THE NATURAL HISTORY OF CHRONIC LYMPHOCYTIC LEUKEMIA DEVELOPMENT AS EARLY AS 16 YEARS BEFORE DIAGNOSIS

Author

Martijn Kolijn, Pieter, primary, Späth, Florentin, additional, Khouja, Mouhamad, additional, Hengeveld, Paul, additional, van der Straten, Lina, additional, Darzentas, Nikos, additional, Hultdin, Magnus, additional, D. Mckay, James, additional, Pott, Christiane, additional, C.H. Vermeulen, Roel, additional, and Langerak, Anton, additional

Published
2023
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18. Next-generation sequencing of immunoglobulin gene rearrangements for clonality assessment: a technical feasibility study by EuroClonality-NGS

Author

Scheijen, Blanca, Meijers, Ruud W. J., Rijntjes, Jos, van der Klift, Michèle Y., Möbs, Markus, Steinhilber, Julia, Reigl, Tomas, van den Brand, Michiel, Kotrová, Michaela, Ritter, Julia-Marie, Catherwood, Mark A., Stamatopoulos, Kostas, Brüggemann, Monika, Davi, Frédéric, Darzentas, Nikos, Pott, Christiane, Fend, Falko, Hummel, Michael, Langerak, Anton W., Groenen, Patricia J. T. A., and on behalf of the EuroClonality-NGS Working Group

Published
2019
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19. Quality control and quantification in IG/TR next-generation sequencing marker identification: protocols and bioinformatic functionalities by EuroClonality-NGS

Author

Knecht, Henrik, Reigl, Tomas, Kotrová, Michaela, Appelt, Franziska, Stewart, Peter, Bystry, Vojtech, Krejci, Adam, Grioni, Andrea, Pal, Karol, Stranska, Kamila, Plevova, Karla, Rijntjes, Jos, Songia, Simona, Svatoň, Michael, Froňková, Eva, Bartram, Jack, Scheijen, Blanca, Herrmann, Dietrich, García-Sanz, Ramón, Hancock, Jeremy, Moppett, John, van Dongen, Jacques J. M., Cazzaniga, Giovanni, Davi, Frédéric, Groenen, Patricia J. T. A., Hummel, Michael, Macintyre, Elizabeth A., Stamatopoulos, Kostas, Trka, Jan, Langerak, Anton W., Gonzalez, David, Pott, Christiane, Brüggemann, Monika, Darzentas, Nikos, and on behalf of the EuroClonality-NGS Working Group

Published
2019
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20. Standardized next-generation sequencing of immunoglobulin and T-cell receptor gene recombinations for MRD marker identification in acute lymphoblastic leukaemia; a EuroClonality-NGS validation study

Author

Brüggemann, Monika, Kotrová, Michaela, Knecht, Henrik, Bartram, Jack, Boudjogrha, Myriam, Bystry, Vojtech, Fazio, Grazia, Froňková, Eva, Giraud, Mathieu, Grioni, Andrea, Hancock, Jeremy, Herrmann, Dietrich, Jiménez, Cristina, Krejci, Adam, Moppett, John, Reigl, Tomas, Salson, Mikael, Scheijen, Blanca, Schwarz, Martin, Songia, Simona, Svaton, Michael, van Dongen, Jacques J. M., Villarese, Patrick, Wakeman, Stephanie, Wright, Gary, Cazzaniga, Giovanni, Davi, Frédéric, García-Sanz, Ramón, Gonzalez, David, Groenen, Patricia J. T. A., Hummel, Michael, Macintyre, Elizabeth A., Stamatopoulos, Kostas, Pott, Christiane, Trka, Jan, Darzentas, Nikos, Langerak, Anton W., and on behalf of the EuroClonality-NGS working group

Published
2019
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23. Insights into IGH clonal evolution in BCP-ALL: frequency, mechanisms, associations, and diagnostic implications

Author

Darzentas, Franziska, primary, Szczepanowski, Monika, additional, Kotrová, Michaela, additional, Hartmann, Alina, additional, Beder, Thomas, additional, Gökbuget, Nicola, additional, Schwartz, Stefan, additional, Bastian, Lorenz, additional, Baldus, Claudia Dorothea, additional, Pál, Karol, additional, Darzentas, Nikos, additional, and Brüggemann, Monika, additional

Published
2023
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24. Supplemental Table 4 from An Immunogenetic Signature of Ongoing Antigen Interactions in Splenic Marginal Zone Lymphoma Expressing IGHV1-2*04 Receptors

Author

Bikos, Vasilis, primary, Karypidou, Maria, primary, Stalika, Evangelia, primary, Baliakas, Panagiotis, primary, Xochelli, Aliki, primary, Sutton, Lesley-Ann, primary, Papadopoulos, George, primary, Agathangelidis, Andreas, primary, Papadopoulou, Evdoxia, primary, Davis, Zadie, primary, Algara, Patricia, primary, Kanellis, George, primary, Traverse-Glehen, Alexandra, primary, Mollejo, Manuela, primary, Anagnostopoulos, Achilles, primary, Ponzoni, Maurilio, primary, Gonzalez, David, primary, Pospisilova, Sarka, primary, Matutes, Estella, primary, Piris, Miguel Angel, primary, Papadaki, Theodora, primary, Ghia, Paolo, primary, Rosenquist, Richard, primary, Oscier, David, primary, Darzentas, Nikos, primary, Tzovaras, Dimitrios, primary, Belessi, Chrysoula, primary, Hadzidimitriou, Anastasia, primary, and Stamatopoulos, Kostas, primary

Published
2023
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25. Supplemental Table 5 from An Immunogenetic Signature of Ongoing Antigen Interactions in Splenic Marginal Zone Lymphoma Expressing IGHV1-2*04 Receptors

Author

Bikos, Vasilis, primary, Karypidou, Maria, primary, Stalika, Evangelia, primary, Baliakas, Panagiotis, primary, Xochelli, Aliki, primary, Sutton, Lesley-Ann, primary, Papadopoulos, George, primary, Agathangelidis, Andreas, primary, Papadopoulou, Evdoxia, primary, Davis, Zadie, primary, Algara, Patricia, primary, Kanellis, George, primary, Traverse-Glehen, Alexandra, primary, Mollejo, Manuela, primary, Anagnostopoulos, Achilles, primary, Ponzoni, Maurilio, primary, Gonzalez, David, primary, Pospisilova, Sarka, primary, Matutes, Estella, primary, Piris, Miguel Angel, primary, Papadaki, Theodora, primary, Ghia, Paolo, primary, Rosenquist, Richard, primary, Oscier, David, primary, Darzentas, Nikos, primary, Tzovaras, Dimitrios, primary, Belessi, Chrysoula, primary, Hadzidimitriou, Anastasia, primary, and Stamatopoulos, Kostas, primary

Published
2023
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26. Supplemental Table 1 from An Immunogenetic Signature of Ongoing Antigen Interactions in Splenic Marginal Zone Lymphoma Expressing IGHV1-2*04 Receptors

Author

Bikos, Vasilis, primary, Karypidou, Maria, primary, Stalika, Evangelia, primary, Baliakas, Panagiotis, primary, Xochelli, Aliki, primary, Sutton, Lesley-Ann, primary, Papadopoulos, George, primary, Agathangelidis, Andreas, primary, Papadopoulou, Evdoxia, primary, Davis, Zadie, primary, Algara, Patricia, primary, Kanellis, George, primary, Traverse-Glehen, Alexandra, primary, Mollejo, Manuela, primary, Anagnostopoulos, Achilles, primary, Ponzoni, Maurilio, primary, Gonzalez, David, primary, Pospisilova, Sarka, primary, Matutes, Estella, primary, Piris, Miguel Angel, primary, Papadaki, Theodora, primary, Ghia, Paolo, primary, Rosenquist, Richard, primary, Oscier, David, primary, Darzentas, Nikos, primary, Tzovaras, Dimitrios, primary, Belessi, Chrysoula, primary, Hadzidimitriou, Anastasia, primary, and Stamatopoulos, Kostas, primary

Published
2023
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27. Figure S2B from Chronic Lymphocytic Leukemia with Mutated IGHV4-34 Receptors: Shared and Distinct Immunogenetic Features and Clinical Outcomes

Author

Xochelli, Aliki, primary, Baliakas, Panagiotis, primary, Kavakiotis, Ioannis, primary, Agathangelidis, Andreas, primary, Sutton, Lesley-Ann, primary, Minga, Eva, primary, Ntoufa, Stavroula, primary, Tausch, Eugen, primary, Yan, Xiao-Jie, primary, Shanafelt, Tait, primary, Plevova, Karla, primary, Boudjogra, Myriam, primary, Rossi, Davide, primary, Davis, Zadie, primary, Navarro, Alba, primary, Sandberg, Yorick, primary, Vojdeman, Fie Juhl, primary, Scarfo, Lydia, primary, Stavroyianni, Niki, primary, Sudarikov, Andrey, primary, Veronese, Silvio, primary, Tzenou, Tatiana, primary, Karan-Djurasevic, Teodora, primary, Catherwood, Mark, primary, Kienle, Dirk, primary, Chatzouli, Maria, primary, Facco, Monica, primary, Bahlo, Jasmin, primary, Pott, Christiane, primary, Pedersen, Lone Bredo, primary, Mansouri, Larry, primary, Smedby, Karin E., primary, Chu, Charles C., primary, Giudicelli, Véronique, primary, Lefranc, Marie-Paule, primary, Panagiotidis, Panagiotis, primary, Juliusson, Gunnar, primary, Anagnostopoulos, Achilles, primary, Vlahavas, Ioannis, primary, Antic, Darko, primary, Trentin, Livio, primary, Montillo, Marco, primary, Niemann, Carsten, primary, Döhner, Hartmut, primary, Langerak, Anton W., primary, Pospisilova, Sarka, primary, Hallek, Michael, primary, Campo, Elias, primary, Chiorazzi, Nicholas, primary, Maglaveras, Nikos, primary, Oscier, David, primary, Gaidano, Gianluca, primary, Jelinek, Diane F., primary, Stilgenbauer, Stephan, primary, Chouvarda, Ioanna, primary, Darzentas, Nikos, primary, Belessi, Chrysoula, primary, Davi, Frederic, primary, Hadzidimitriou, Anastasia, primary, Rosenquist, Richard, primary, Ghia, Paolo, primary, and Stamatopoulos, Kostas, primary

Published
2023
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28. Supplemental Table 3 from An Immunogenetic Signature of Ongoing Antigen Interactions in Splenic Marginal Zone Lymphoma Expressing IGHV1-2*04 Receptors

Author

Bikos, Vasilis, primary, Karypidou, Maria, primary, Stalika, Evangelia, primary, Baliakas, Panagiotis, primary, Xochelli, Aliki, primary, Sutton, Lesley-Ann, primary, Papadopoulos, George, primary, Agathangelidis, Andreas, primary, Papadopoulou, Evdoxia, primary, Davis, Zadie, primary, Algara, Patricia, primary, Kanellis, George, primary, Traverse-Glehen, Alexandra, primary, Mollejo, Manuela, primary, Anagnostopoulos, Achilles, primary, Ponzoni, Maurilio, primary, Gonzalez, David, primary, Pospisilova, Sarka, primary, Matutes, Estella, primary, Piris, Miguel Angel, primary, Papadaki, Theodora, primary, Ghia, Paolo, primary, Rosenquist, Richard, primary, Oscier, David, primary, Darzentas, Nikos, primary, Tzovaras, Dimitrios, primary, Belessi, Chrysoula, primary, Hadzidimitriou, Anastasia, primary, and Stamatopoulos, Kostas, primary

Published
2023
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29. Supplemental Table 2 from An Immunogenetic Signature of Ongoing Antigen Interactions in Splenic Marginal Zone Lymphoma Expressing IGHV1-2*04 Receptors

Author

Bikos, Vasilis, primary, Karypidou, Maria, primary, Stalika, Evangelia, primary, Baliakas, Panagiotis, primary, Xochelli, Aliki, primary, Sutton, Lesley-Ann, primary, Papadopoulos, George, primary, Agathangelidis, Andreas, primary, Papadopoulou, Evdoxia, primary, Davis, Zadie, primary, Algara, Patricia, primary, Kanellis, George, primary, Traverse-Glehen, Alexandra, primary, Mollejo, Manuela, primary, Anagnostopoulos, Achilles, primary, Ponzoni, Maurilio, primary, Gonzalez, David, primary, Pospisilova, Sarka, primary, Matutes, Estella, primary, Piris, Miguel Angel, primary, Papadaki, Theodora, primary, Ghia, Paolo, primary, Rosenquist, Richard, primary, Oscier, David, primary, Darzentas, Nikos, primary, Tzovaras, Dimitrios, primary, Belessi, Chrysoula, primary, Hadzidimitriou, Anastasia, primary, and Stamatopoulos, Kostas, primary

Published
2023
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30. Table S1 from Chronic Lymphocytic Leukemia with Mutated IGHV4-34 Receptors: Shared and Distinct Immunogenetic Features and Clinical Outcomes

Author

Xochelli, Aliki, primary, Baliakas, Panagiotis, primary, Kavakiotis, Ioannis, primary, Agathangelidis, Andreas, primary, Sutton, Lesley-Ann, primary, Minga, Eva, primary, Ntoufa, Stavroula, primary, Tausch, Eugen, primary, Yan, Xiao-Jie, primary, Shanafelt, Tait, primary, Plevova, Karla, primary, Boudjogra, Myriam, primary, Rossi, Davide, primary, Davis, Zadie, primary, Navarro, Alba, primary, Sandberg, Yorick, primary, Vojdeman, Fie Juhl, primary, Scarfo, Lydia, primary, Stavroyianni, Niki, primary, Sudarikov, Andrey, primary, Veronese, Silvio, primary, Tzenou, Tatiana, primary, Karan-Djurasevic, Teodora, primary, Catherwood, Mark, primary, Kienle, Dirk, primary, Chatzouli, Maria, primary, Facco, Monica, primary, Bahlo, Jasmin, primary, Pott, Christiane, primary, Pedersen, Lone Bredo, primary, Mansouri, Larry, primary, Smedby, Karin E., primary, Chu, Charles C., primary, Giudicelli, Véronique, primary, Lefranc, Marie-Paule, primary, Panagiotidis, Panagiotis, primary, Juliusson, Gunnar, primary, Anagnostopoulos, Achilles, primary, Vlahavas, Ioannis, primary, Antic, Darko, primary, Trentin, Livio, primary, Montillo, Marco, primary, Niemann, Carsten, primary, Döhner, Hartmut, primary, Langerak, Anton W., primary, Pospisilova, Sarka, primary, Hallek, Michael, primary, Campo, Elias, primary, Chiorazzi, Nicholas, primary, Maglaveras, Nikos, primary, Oscier, David, primary, Gaidano, Gianluca, primary, Jelinek, Diane F., primary, Stilgenbauer, Stephan, primary, Chouvarda, Ioanna, primary, Darzentas, Nikos, primary, Belessi, Chrysoula, primary, Davi, Frederic, primary, Hadzidimitriou, Anastasia, primary, Rosenquist, Richard, primary, Ghia, Paolo, primary, and Stamatopoulos, Kostas, primary

Published
2023
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31. Supplemental Figure 1 from An Immunogenetic Signature of Ongoing Antigen Interactions in Splenic Marginal Zone Lymphoma Expressing IGHV1-2*04 Receptors

Author

Bikos, Vasilis, primary, Karypidou, Maria, primary, Stalika, Evangelia, primary, Baliakas, Panagiotis, primary, Xochelli, Aliki, primary, Sutton, Lesley-Ann, primary, Papadopoulos, George, primary, Agathangelidis, Andreas, primary, Papadopoulou, Evdoxia, primary, Davis, Zadie, primary, Algara, Patricia, primary, Kanellis, George, primary, Traverse-Glehen, Alexandra, primary, Mollejo, Manuela, primary, Anagnostopoulos, Achilles, primary, Ponzoni, Maurilio, primary, Gonzalez, David, primary, Pospisilova, Sarka, primary, Matutes, Estella, primary, Piris, Miguel Angel, primary, Papadaki, Theodora, primary, Ghia, Paolo, primary, Rosenquist, Richard, primary, Oscier, David, primary, Darzentas, Nikos, primary, Tzovaras, Dimitrios, primary, Belessi, Chrysoula, primary, Hadzidimitriou, Anastasia, primary, and Stamatopoulos, Kostas, primary

Published
2023
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32. Data from Molecular Subsets of Mantle Cell Lymphoma Defined by the IGHV Mutational Status and SOX11 Expression Have Distinct Biologic and Clinical Features

Author

Navarro, Alba, primary, Clot, Guillem, primary, Royo, Cristina, primary, Jares, Pedro, primary, Hadzidimitriou, Anastasia, primary, Agathangelidis, Andreas, primary, Bikos, Vasilis, primary, Darzentas, Nikos, primary, Papadaki, Theodora, primary, Salaverria, Itziar, primary, Pinyol, Magda, primary, Puig, Xavier, primary, Palomero, Jara, primary, Vegliante, Maria Carmela, primary, Amador, Virgina, primary, Martinez-Trillos, Alejandra, primary, Stefancikova, Lenka, primary, Wiestner, Adrian, primary, Wilson, Wyndham, primary, Pott, Christiane, primary, Calasanz, Maria Jose, primary, Trim, Nicola, primary, Erber, Wendy, primary, Sander, Birgitta, primary, Ott, German, primary, Rosenwald, Andreas, primary, Colomer, Dolors, primary, Giné, Eva, primary, Siebert, Reiner, primary, Lopez-Guillermo, Armando, primary, Stamatopoulos, Kostas, primary, Beà, Sílvia, primary, and Campo, Elías, primary

Published
2023
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33. Supplementary Table 4 from Molecular Subsets of Mantle Cell Lymphoma Defined by the IGHV Mutational Status and SOX11 Expression Have Distinct Biologic and Clinical Features

Author

Navarro, Alba, primary, Clot, Guillem, primary, Royo, Cristina, primary, Jares, Pedro, primary, Hadzidimitriou, Anastasia, primary, Agathangelidis, Andreas, primary, Bikos, Vasilis, primary, Darzentas, Nikos, primary, Papadaki, Theodora, primary, Salaverria, Itziar, primary, Pinyol, Magda, primary, Puig, Xavier, primary, Palomero, Jara, primary, Vegliante, Maria Carmela, primary, Amador, Virgina, primary, Martinez-Trillos, Alejandra, primary, Stefancikova, Lenka, primary, Wiestner, Adrian, primary, Wilson, Wyndham, primary, Pott, Christiane, primary, Calasanz, Maria Jose, primary, Trim, Nicola, primary, Erber, Wendy, primary, Sander, Birgitta, primary, Ott, German, primary, Rosenwald, Andreas, primary, Colomer, Dolors, primary, Giné, Eva, primary, Siebert, Reiner, primary, Lopez-Guillermo, Armando, primary, Stamatopoulos, Kostas, primary, Beà, Sílvia, primary, and Campo, Elías, primary

Published
2023
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34. Supplementary Figure 3 from Molecular Subsets of Mantle Cell Lymphoma Defined by the IGHV Mutational Status and SOX11 Expression Have Distinct Biologic and Clinical Features

Author

Navarro, Alba, primary, Clot, Guillem, primary, Royo, Cristina, primary, Jares, Pedro, primary, Hadzidimitriou, Anastasia, primary, Agathangelidis, Andreas, primary, Bikos, Vasilis, primary, Darzentas, Nikos, primary, Papadaki, Theodora, primary, Salaverria, Itziar, primary, Pinyol, Magda, primary, Puig, Xavier, primary, Palomero, Jara, primary, Vegliante, Maria Carmela, primary, Amador, Virgina, primary, Martinez-Trillos, Alejandra, primary, Stefancikova, Lenka, primary, Wiestner, Adrian, primary, Wilson, Wyndham, primary, Pott, Christiane, primary, Calasanz, Maria Jose, primary, Trim, Nicola, primary, Erber, Wendy, primary, Sander, Birgitta, primary, Ott, German, primary, Rosenwald, Andreas, primary, Colomer, Dolors, primary, Giné, Eva, primary, Siebert, Reiner, primary, Lopez-Guillermo, Armando, primary, Stamatopoulos, Kostas, primary, Beà, Sílvia, primary, and Campo, Elías, primary

Published
2023
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35. Supplementary Table 1 from Molecular Subsets of Mantle Cell Lymphoma Defined by the IGHV Mutational Status and SOX11 Expression Have Distinct Biologic and Clinical Features

Author

Navarro, Alba, primary, Clot, Guillem, primary, Royo, Cristina, primary, Jares, Pedro, primary, Hadzidimitriou, Anastasia, primary, Agathangelidis, Andreas, primary, Bikos, Vasilis, primary, Darzentas, Nikos, primary, Papadaki, Theodora, primary, Salaverria, Itziar, primary, Pinyol, Magda, primary, Puig, Xavier, primary, Palomero, Jara, primary, Vegliante, Maria Carmela, primary, Amador, Virgina, primary, Martinez-Trillos, Alejandra, primary, Stefancikova, Lenka, primary, Wiestner, Adrian, primary, Wilson, Wyndham, primary, Pott, Christiane, primary, Calasanz, Maria Jose, primary, Trim, Nicola, primary, Erber, Wendy, primary, Sander, Birgitta, primary, Ott, German, primary, Rosenwald, Andreas, primary, Colomer, Dolors, primary, Giné, Eva, primary, Siebert, Reiner, primary, Lopez-Guillermo, Armando, primary, Stamatopoulos, Kostas, primary, Beà, Sílvia, primary, and Campo, Elías, primary

Published
2023
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36. Supplementary Figure 2 from Molecular Subsets of Mantle Cell Lymphoma Defined by the IGHV Mutational Status and SOX11 Expression Have Distinct Biologic and Clinical Features

Author

Navarro, Alba, primary, Clot, Guillem, primary, Royo, Cristina, primary, Jares, Pedro, primary, Hadzidimitriou, Anastasia, primary, Agathangelidis, Andreas, primary, Bikos, Vasilis, primary, Darzentas, Nikos, primary, Papadaki, Theodora, primary, Salaverria, Itziar, primary, Pinyol, Magda, primary, Puig, Xavier, primary, Palomero, Jara, primary, Vegliante, Maria Carmela, primary, Amador, Virgina, primary, Martinez-Trillos, Alejandra, primary, Stefancikova, Lenka, primary, Wiestner, Adrian, primary, Wilson, Wyndham, primary, Pott, Christiane, primary, Calasanz, Maria Jose, primary, Trim, Nicola, primary, Erber, Wendy, primary, Sander, Birgitta, primary, Ott, German, primary, Rosenwald, Andreas, primary, Colomer, Dolors, primary, Giné, Eva, primary, Siebert, Reiner, primary, Lopez-Guillermo, Armando, primary, Stamatopoulos, Kostas, primary, Beà, Sílvia, primary, and Campo, Elías, primary

Published
2023
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37. Supplementary Figure 1 from Molecular Subsets of Mantle Cell Lymphoma Defined by the IGHV Mutational Status and SOX11 Expression Have Distinct Biologic and Clinical Features

Author

Navarro, Alba, primary, Clot, Guillem, primary, Royo, Cristina, primary, Jares, Pedro, primary, Hadzidimitriou, Anastasia, primary, Agathangelidis, Andreas, primary, Bikos, Vasilis, primary, Darzentas, Nikos, primary, Papadaki, Theodora, primary, Salaverria, Itziar, primary, Pinyol, Magda, primary, Puig, Xavier, primary, Palomero, Jara, primary, Vegliante, Maria Carmela, primary, Amador, Virgina, primary, Martinez-Trillos, Alejandra, primary, Stefancikova, Lenka, primary, Wiestner, Adrian, primary, Wilson, Wyndham, primary, Pott, Christiane, primary, Calasanz, Maria Jose, primary, Trim, Nicola, primary, Erber, Wendy, primary, Sander, Birgitta, primary, Ott, German, primary, Rosenwald, Andreas, primary, Colomer, Dolors, primary, Giné, Eva, primary, Siebert, Reiner, primary, Lopez-Guillermo, Armando, primary, Stamatopoulos, Kostas, primary, Beà, Sílvia, primary, and Campo, Elías, primary

Published
2023
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38. Supplementary Table 2 from Molecular Subsets of Mantle Cell Lymphoma Defined by the IGHV Mutational Status and SOX11 Expression Have Distinct Biologic and Clinical Features

Author

Navarro, Alba, primary, Clot, Guillem, primary, Royo, Cristina, primary, Jares, Pedro, primary, Hadzidimitriou, Anastasia, primary, Agathangelidis, Andreas, primary, Bikos, Vasilis, primary, Darzentas, Nikos, primary, Papadaki, Theodora, primary, Salaverria, Itziar, primary, Pinyol, Magda, primary, Puig, Xavier, primary, Palomero, Jara, primary, Vegliante, Maria Carmela, primary, Amador, Virgina, primary, Martinez-Trillos, Alejandra, primary, Stefancikova, Lenka, primary, Wiestner, Adrian, primary, Wilson, Wyndham, primary, Pott, Christiane, primary, Calasanz, Maria Jose, primary, Trim, Nicola, primary, Erber, Wendy, primary, Sander, Birgitta, primary, Ott, German, primary, Rosenwald, Andreas, primary, Colomer, Dolors, primary, Giné, Eva, primary, Siebert, Reiner, primary, Lopez-Guillermo, Armando, primary, Stamatopoulos, Kostas, primary, Beà, Sílvia, primary, and Campo, Elías, primary

Published
2023
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39. Supplementary Table 3 from Molecular Subsets of Mantle Cell Lymphoma Defined by the IGHV Mutational Status and SOX11 Expression Have Distinct Biologic and Clinical Features

Author

Navarro, Alba, primary, Clot, Guillem, primary, Royo, Cristina, primary, Jares, Pedro, primary, Hadzidimitriou, Anastasia, primary, Agathangelidis, Andreas, primary, Bikos, Vasilis, primary, Darzentas, Nikos, primary, Papadaki, Theodora, primary, Salaverria, Itziar, primary, Pinyol, Magda, primary, Puig, Xavier, primary, Palomero, Jara, primary, Vegliante, Maria Carmela, primary, Amador, Virgina, primary, Martinez-Trillos, Alejandra, primary, Stefancikova, Lenka, primary, Wiestner, Adrian, primary, Wilson, Wyndham, primary, Pott, Christiane, primary, Calasanz, Maria Jose, primary, Trim, Nicola, primary, Erber, Wendy, primary, Sander, Birgitta, primary, Ott, German, primary, Rosenwald, Andreas, primary, Colomer, Dolors, primary, Giné, Eva, primary, Siebert, Reiner, primary, Lopez-Guillermo, Armando, primary, Stamatopoulos, Kostas, primary, Beà, Sílvia, primary, and Campo, Elías, primary

Published
2023
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40. NGS better discriminates true MRD positivity for the risk stratification of childhood ALL treated on an MRD-based protocol

Author

Svaton, Michael, primary, Skotnicova, Aneta, additional, Reznickova, Leona, additional, Rennerova, Andrea, additional, Valova, Tatana, additional, Kotrova, Michaela, additional, van der Velden, Vincent H. J., additional, Brüggemann, Monika, additional, Darzentas, Nikos, additional, Langerak, Anton W., additional, Zuna, Jan, additional, Stary, Jan, additional, Trka, Jan, additional, and Fronkova, Eva, additional

Published
2023
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41. The presence of CLL-associated stereotypic B cell receptors in the normal BCR repertoire from healthy individuals increases with age

Author

Muggen, Alice F., de Jong, Madelon, Wolvers-Tettero, Ingrid L. M., Kallemeijn, Martine J., Teodósio, Cristina, Darzentas, Nikos, Stadhouders, Ralph, IJspeert, Hanna, van der Burg, Mirjam, van IJcken, Wilfred FJ, Verhaar, Jan A. N., Abdulahad, Wayel H., Brouwer, Elisabeth, Boots, Annemieke M. H., Hendriks, Rudi W., van Dongen, Jacques J. M., and Langerak, Anton W.

Published
2019
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43. IGH Rearrangement Evolution in Adult KMT2A-rearranged B-cell Precursor ALL: Implications for Cell-of-origin and MRD Monitoring

Author

Darzentas, Franziska, primary, Szczepanowski, Monika, additional, Kotrová, Michaela, additional, Kelm, Miriam, additional, Hartmann, Alina, additional, Beder, Thomas, additional, Gökbuget, Nicola, additional, Neumann, Martin, additional, Bastian, Lorenz, additional, Baldus, Claudia D., additional, Pál, Karol, additional, Darzentas, Nikos, additional, and Brüggemann, Monika, additional

Published
2022
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44. Somatic TP53 mutations are pre-leukemic events in acute lymphoblastic leukemia

Author

Chitadze, Guranda, primary, Stengel, Anna, additional, John-Klaua, Cathrin, additional, Bruckmüller, Julien, additional, Trautmann, Heiko, additional, Kotrova, Michaela, additional, Darzentas, Franziska, additional, Kelm, Miriam, additional, Pal, Karol, additional, Darzentas, Nikos, additional, Bastian, Lorenz, additional, Kehden, Britta, additional, Wessels, Wiebke, additional, Ströh, Aeint-Steffen, additional, Oberg, Hans-Heinrich, additional, Altrock, Philipp M, additional, Baer, Constance, additional, Meggendorfer, Manja, additional, Goekbuget, Nicola, additional, Baldus, Claudia D., additional, Haferlach, Claudia, additional, and Brüggemann, Monika, additional

Published
2022
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45. Genotyping and Minimal Residual Disease (MRD) Assessment in cfDNA By the Euroclonality-NGS DNA Capture (EC-NDC) Panel in Mantle Cell Lymphoma (MCL)

Author

Khouja, Mouhamad, primary, Genuardi, Elisa, additional, Ferrero, Simone, additional, Alessandria, Beatrice, additional, Verhagen, Onno, additional, Homburg, Christa, additional, van der Velden, Vincent H.J., additional, Gameiro, Paula, additional, García-Sanz, Ramón, additional, Medina, Alejandro, additional, Fronkova, Eva, additional, Brüggemann, Monika, additional, Dreyling, Martin, additional, Hoster, Eva, additional, Langerak, Anton, additional, Darzentas, Nikos, additional, Pal, Karol, additional, Stewart, Peter James, additional, Gonzalez, David, additional, and Pott, Christiane, additional

Published
2022
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46. Somatic TP53 mutations are preleukemic events in acute lymphoblastic leukemia

Author

Chitadze, Guranda, Stengel, Anna, John-Klaua, Cathrin, Bruckmüller, Julien, Trautmann, Heiko, Kotrova, Michaela, Darzentas, Franziska, Kelm, Miriam, Pal, Karol, Darzentas, Nikos, Bastian, Lorenz, Kehden, Britta, Wessels, Wiebke, Ströh, Aeint-Steffen, Oberg, Hans-Heinrich, Altrock, Philipp M., Baer, Constance, Meggendorfer, Manja, Gökbuget, Nicola, Baldus, Claudia D., Haferlach, Claudia, and Brüggemann, Monika

Published
2023
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47. Clinical effect of stereotyped B-cell receptor immunoglobulins in chronic lymphocytic leukaemia: a retrospective multicentre study

Author

Baliakas, Panagiotis, Hadzidimitriou, Anastasia, Sutton, Lesley-Ann, Minga, Eva, Agathangelidis, Andreas, Nichelatti, Michele, Tsanousa, Athina, Scarfò, Lydia, Davis, Zadie, Yan, Xiao-Jie, Shanafelt, Tait, Plevova, Karla, Sandberg, Yorick, Vojdeman, Fie Juhl, Boudjogra, Myriam, Tzenou, Tatiana, Chatzouli, Maria, Chu, Charles C, Veronese, Silvio, Gardiner, Anne, Mansouri, Larry, Smedby, Karin E, Pedersen, Lone Bredo, van Lom, Kirsten, Giudicelli, Véronique, Francova, Hana Skuhrova, Nguyen-Khac, Florence, Panagiotidis, Panagiotis, Juliusson, Gunnar, Angelis, Lefteris, Anagnostopoulos, Achilles, Lefranc, Marie-Paule, Facco, Monica, Trentin, Livio, Catherwood, Mark, Montillo, Marco, Geisler, Christian H, Langerak, Anton W, Pospisilova, Sarka, Chiorazzi, Nicholas, Oscier, David, Jelinek, Diane F, Darzentas, Nikos, Belessi, Chrysoula, Davi, Frederic, Rosenquist, Richard, Ghia, Paolo, and Stamatopoulos, Kostas

Published
2014
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48. Identification of New Antibodies Targeting Malignant Plasma Cells for Immunotherapy by Next-Generation Sequencing-Assisted Phage Display

Author

Krohn, Steffen, primary, Boje, Ammelie Svea, additional, Gehlert, Carina Lynn, additional, Lutz, Sebastian, additional, Darzentas, Nikos, additional, Knecht, Henrik, additional, Herrmann, Dietrich, additional, Brüggemann, Monika, additional, Scheidig, Axel J., additional, Weisel, Katja, additional, Gramatzki, Martin, additional, Peipp, Matthias, additional, and Klausz, Katja, additional

Published
2022
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49. ARResT/Interrogate Immunoprofiling Platform: Concepts, Workflows, and Insights

Author

Darzentas, Nikos

Subjects
Receptors, Antigen, T-Cell, High-Throughput Nucleotide Sequencing, Immunoglobulins, Research Article, Workflow
Abstract

ARResT/Interrogate was built within the EuroClonality-NGS working group to meet the challenge of developing and applying assays for the high-throughput sequence-based profiling of immunoglobulin (IG) and T-cell receptor (TR) repertoires. We herein present basic concepts, outline the main workflow, delve into EuroClonality-NGS-specific aspects, and share insights from our experiences with the platform.

Published
2022

50. cfDNA-Based NGS IG Analysis in Lymphoma

Author

Pott, Christiane, Kotrova, Michaela, Darzentas, Nikos, Brüggemann, Monika, and Khouja, Mouhamad

Subjects
Gene Rearrangement, Lymphoma, B-Cell, Neoplasm, Residual, Genes, Immunoglobulin, Lymphoma, Biomarkers, Tumor, Liquid Biopsy, Humans, Immunoglobulins, Cell-Free Nucleic Acids, Research Article, Circulating Tumor DNA, Clone Cells
Abstract

Liquid biopsy is a novel diagnostic approach at first developed to characterize the molecular profile of solid tumors by analyzing body fluids. For cancer patients, it represents a noninvasive way to monitor the status of the solid tumor with respect to representative biomarkers. There is growing interest in the utilization of circulating tumor DNA (ctDNA) analysis also in the diagnostic and prognostic fields of lymphomas. Clonal immunoglobulin (IG) gene rearrangements are fingerprints of the respective lymphoid malignancy and thus are highly suited as specific molecular targets for minimal residual disease (MRD) detection. Tracing of the clonal IG rearrangement patterns in ctDNA pool during treatment can be used for MRD assessment in B-cell lymphomas. Here, we describe a reproducible next-generation sequencing assay to identify and characterize clonal IG gene rearrangements for MRD detection in cell-free DNA.

Published
2022

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