Search

Your search keyword '"Dasari, Rajaneekar"' showing total 14 results
Start Over Author "Dasari, Rajaneekar"
14 results on '"Dasari, Rajaneekar"'

2. A living ex vivo platform for functional, personalized brain cancer diagnosis

Author

Mann, Breanna, Zhang, Xiaopei, Bell, Noah, Adefolaju, Adebimpe, Thang, Morrent, Dasari, Rajaneekar, Kanchi, Krishna, Valdivia, Alain, Yang, Yang, Buckley, Andrew, Lettry, Vivien, Quinsey, Carolyn, Rauf, Yasmeen, Kram, David, Cassidy, Noah, Vaziri, Cyrus, Corcoran, David L., Rego, Stephen, Jiang, Yuchao, Graves, Lee M., Dunn, Denise, Floyd, Scott, Baldwin, Albert, Hingtgen, Shawn, and Satterlee, Andrew B.

Published
2023
Full Text
View/download PDF

3. Auto-loaded TRAIL-exosomes derived from induced neural stem cells for brain cancer therapy

Author

Zhang, Xiaopei, primary, Taylor, Hannah, additional, Valdivia, Alain, additional, Dasari, Rajaneekar, additional, Buckley, Andrew, additional, Bonacquisti, Emily, additional, Nguyen, Juliane, additional, Kanchi, Krishna, additional, Corcoran, David L., additional, Herring, Laura E., additional, Steindler, Dennis A., additional, Baldwin, Albert, additional, Hingtgen, Shawn, additional, and Satterlee, Andrew Benson, additional

Published
2024
Full Text
View/download PDF

6. MODL-44. DEVELOPMENT OF A NOVEL, PERSONALIZED DRUG SENSITIVITY SCORE TO ASSESS TUMOR KILLING AND TOXICITY WITHIN AN ORGANOTYPIC BRAIN SLICE CULTURE PLATFORM

Author

Mann, Breanna, primary, Zhang, Xiaopei, additional, Bell, Noah, additional, Adefolaju, Adebimpe, additional, Thang, Morrent, additional, Dasari, Rajaneekar, additional, Kanchi, Krishna, additional, Valdivia, Alain, additional, Yang, Yang, additional, Buckley, Andrew, additional, Lettry, Vivien, additional, Quinsey, Carolyn, additional, Rauf, Yasmeen, additional, Kram, David, additional, Cassidy, Noah, additional, Vaziri, Cyrus, additional, Corcoran, David L, additional, Rego, Stephen, additional, Jiang, Yuchao, additional, Graves, Lee M, additional, Dunn, Denise, additional, Floyd, Scott, additional, Baldwin, Albert, additional, Hingtgen, Shawn, additional, and Satterlee, Andrew B, additional

Published
2023
Full Text
View/download PDF

7. MODL-28. LIVING EX VIVO ORGANOTYPIC BRAIN SLICE CULTURES AS A COMPREHENSIVE SUBSTRATE FOR TUMOR ENGRAFTMENT AND ANALYSIS

Author

Adefolaju, Adebimpe, primary, Mann, Breanna, additional, Zhang, Xiaopei, additional, Bell, Noah, additional, Thang, Morrent, additional, Dasari, Rajaneekar, additional, Kanchi, Krishna, additional, Valdivia, Alain, additional, Yang, Yang, additional, Buckley, Andrew, additional, Lettry, Vivien, additional, Quinsey, Carolyn, additional, Rauf, Yasmeen, additional, Kram, David, additional, Cassidy, Noah, additional, Vaziri, Cyrus, additional, Corcoran, David L, additional, Rego, Stephen, additional, Jiang, Yuchao, additional, Graves, Lee M, additional, Dunn, Denise, additional, Floyd, Scott, additional, Baldwin, Albert, additional, Hingtgen, Shawn, additional, and Satterlee, Andrew B, additional

Published
2023
Full Text
View/download PDF

8. CNSC-39. GENERATION AND CHARACTERIZATION OF LIVING ORGANOTYPIC BRAIN SLICE CULTURES AS A NOVEL PRE-CLINICAL MODEL FOR BRAIN CANCER

Author

Dasari, Rajaneekar, primary, Mann, Breanna, additional, Zhang, Xiaopei, additional, Bell, Noah, additional, Adefolaju, Adebimpe, additional, Thang, Morrent, additional, Kanchi, Krishna, additional, Valdivia, Alain, additional, Yang, Yang, additional, Buckley, Andrew, additional, Lettry, Vivien, additional, Quinsey, Carolyn, additional, Rauf, Yasmeen, additional, Kram, David, additional, Cassidy, Noah, additional, Vaziri, Cyrus, additional, Corcoran, David L, additional, Rego, Stephen, additional, Jiang, Yuchao, additional, Graves, Lee M, additional, Dunn, Denise, additional, Floyd, Scott, additional, Baldwin, Albert, additional, Hingtgen, Shawn, additional, and Satterlee, Andrew B, additional

Published
2023
Full Text
View/download PDF

9. MODL-03. AN EX VIVO PLATFORM BASED ON ORGANOTYPIC BRAIN SLICE CULTURE FOR INFORMING PERSONALIZED BRAIN CANCER THERAPY

Author

Zhang, Xiaopei, primary, Mann, Breanna, additional, Bell, Noah, additional, Adefolaju, Adebimpe, additional, Thang, Morrent, additional, Dasari, Rajaneekar, additional, Kanchi, Krishna, additional, Valdivia, Alain, additional, Yang, Yang, additional, Buckley, Andrew, additional, Lettry, Vivien, additional, Quinsey, Carolyn, additional, Rauf, Yasmeen, additional, Kram, David, additional, Cassidy, Noah, additional, Vaziri, Cyrus, additional, Corcoran, David L, additional, Rego, Stephen, additional, Jiang, Yuchao, additional, Graves, Lee M, additional, Dunn, Denise, additional, Floyd, Scott, additional, Baldwin, Albert, additional, Hingtgen, Shawn, additional, and Satterlee, Andrew B, additional

Published
2023
Full Text
View/download PDF

14. Auto-loaded TRAIL-exosomes derived from induced neural stem cells for brain cancer therapy.

Author

Zhang X, Taylor H, Valdivia A, Dasari R, Buckley A, Bonacquisti E, Nguyen J, Kanchi K, Corcoran DL, Herring LE, Steindler DA, Baldwin A, Hingtgen S, and Satterlee AB

Abstract

Transdifferentiation (TD), a somatic cell reprogramming process that eliminates pluripotent intermediates, creates cells that are ideal for personalized anti-cancer therapy. Here, we provide the first evidence that extracellular vesicles (EVs) from TD-derived induced neural stem cells (Exo-iNSCs) are an efficacious treatment strategy for brain cancer. We found that genetically engineered iNSCs generated EVs loaded with the tumoricidal gene product TRAIL at nearly twice the rate as their parental fibroblasts, and the TRAIL produced by iNSCs were naturally loaded into the lumen of EVs and arrayed across their outer membrane (Exo-iNSC-TRAIL). Uptake studies in ex vivo organotypic brain slice cultures showed Exo-iNSC-TRAIL selectively accumulates within tumor foci, and co-culture assays showed that Exo-iNSC-TRAIL killed metastatic and primary brain cancer cells more effectively than free TRAIL. In an orthotopic mouse model of brain cancer, Exo-iNSC-TRAIL reduced breast-to-brain tumor xenografts around 3000-fold greater than treatment with free TRAIL, with all Exo-iNSC-TRAIL treated animals surviving through 90 days post-treatment. In additional in vivo testing against aggressive U87 and invasive GBM8 glioblastoma tumors, Exo-iNSC-TRAIL also induced a statistically significant increase in survival. These studies establish a new easily generated, stable, tumor-targeted EV to efficaciously treat multiple forms of brain cancer.

Published
2024
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results