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Background: In this study, we wanted to evaluate the incidence of adverse outcomes in pregnancy preceded by spontaneous abortion compared to those preceded by full term live births. Materials and methods: This was a hospital based prospective observational study conducted among 200 pregnant women with history of previous spontaneous abortions attending the antenatal OPD and labour room in the Department of Obstetrics and Gynaecology, J.L.N Hospital and Research Centre, Bhilai, Chhattisgarh, over a period of 11 months from 1st December 2019 to 30th October 2020 after obtaining clearance from Institutional Ethics Committee and written informed consent from the study participants. Results: The incidence of oligohydramnios in case and control groups was 13 and 4% respectively. This has a p value of 0.022 which was statistically significant. The incidence of premature rupture of membrane (PROM) in case and control groups was 22 and 11 % respectively. This has a p value of 0.03 which was statistically significant. The incidence of PPROM in case and control groups was 7 and 1 % respectively. This has a p value of 0.03 which was statistically significant. 65.59 % patients underwent lower segment caesarean section (LSCS) among cases and 50 % patients underwent LSCS among controls. This has a p value of 0.037 which was statistically significant. 5.41 % of cases had emergency caesarean section while 57.14 % of controls had emergency caesarean section which was statistically significant (p value 0.042). 42.86 % of controls had elective caesarean section owing to large number of patients in control group with history of previous caesarean scar. Conclusion: Previous unfavourable pregnancy outcome increases the risk of adverse outcome in the future pregnancies. Majority of abortions in present pregnancy among both cases and controls are of first trimester abortions. There was significant association found between previous spontaneous abortion and oligohydramnios (13%), preterm delivery (16%), PROM (22%), PPROM (7 %), low birth weight (18.28 %), in the subsequent pregnancies. As the number of abortions increases, the incidence of term pregnancies decreases (A1-80.72%, A2-63.64 %, A3 - 60%, A4 - 0%). As the number of abortion increases, the incidence of oligohydramnios increases. The percentage of operative deliveries increases in the cases who had previous abortions. There was significant number of neonatal intensive care unit (NICU) admissions among cases. Previous abortions have a definite impact on the successful outcome of future pregnancies hence history of abortions in previous pregnancy should be investigated and treated. [ABSTRACT FROM AUTHOR]

Objective: To assess the effect of pregnancy on leiomyomas, effect of leiomyomas on pregnancy, the maternal morbidity and mortality and the perinatal outcome in pregnancies associated with leiomyoma. Materials and Methods: This prospective clinical study was conducted at Department of Obstetric and Gynecology, Medical College and Hospital, Kolkata from July 2012 to June 2013 on 40 pregnant women diagnosed with uterine leiomyoma. Results: Out of the total number of 40 cases, 87.5% were more than 25 years of age. Diagnosis was by antenatal ultrasound in 87.5%. Location of leiomyoma was subserous in 60%. They were 10-50cc in size in 50%of cases, single in 77.5%, 3 or more in number in only 15%. In pregnancy, size remained unaltered in 60%, 20% increased in size and 10% showed a decrease in size. At the end of puerperium they disappeared or decreased in size in 87.5% of cases. Complications developed in 35% of cases out of which 12.5% had complete abortions, 5.7% had placental abruption, 5.7% had premature rupture of membrane and 8.6% had preterm labour. Vaginal delivery occurred in 22.5%, 65% underwent LSCD. The major (26.9%) indication was malpresentation, 11.5% for myoma >30cc and 7.7% for leiomyoma in lower uterine segment. Caesarean myomectomy was possible in 50% patients. 5.7% of newborns had an APGAR score <7 at 1 min, all had an APGAR score >7 at 5 mins. Low birth weight babies were 22.9%. Conclusion: The course of leiomyoma in pregnancy is unpredictable, but complications may be avoided by repeated follow-up and a good pregnancy outcome can be achieved. [ABSTRACT FROM AUTHOR]