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3. Euthanasia and assisted suicide in psychiatric patients: A systematic review of the literature

Author

Calati, R, Olié, E, Dassa, D, Gramaglia, C, Guillaume, S, Madeddu, F, Courtet, P, Calati, R, Olié, E, Dassa, D, Gramaglia, C, Guillaume, S, Madeddu, F, and Courtet, P

Abstract

The number of psychiatric patients requesting Euthanasia or Assisted Suicide (EAS) continues to increase. The aims of this systematic review were to: 1) describe the available data related to psychiatric patients having received or requesting EAS (pEAS) for each country in which is allowed; 2) and describe the ethically salient points that arise. PubMed, PsycINFO, and Scopus databases were searched to identify articles published up to September 2020. Among the retrieved publications, only studies on pEAS cases (pEAS-C), pEAS requests, or physician reports/attitude towards pEAS reporting some quantitative data on patients having received or requesting pEAS were retained. Among the 24 included studies, thirteen (54%) were about pEAS in the Netherlands, four (17%) in Belgium, and seven (29%) in Switzerland. Results were different across different countries. In the Netherlands, pEAS-C were mostly women (70–77%) and often had at least two psychiatric disorders (56–97%). Mood disorders were mainly represented (55–70%) together with personality disorders (52–54%). History of suicide attempts was present in 34–52%. Moreover, 37–62% of them had at least one comorbid medical condition. In Belgium pEAS-C were mostly women (75%), but the majority (71%) had a single diagnosis, mood disorder. In Switzerland available data were less detailed. As pEAS-C seem to be very similar to ‘traditional suicides’, pEAS procedures should be carefully revised to establish specific criteria of access and guidelines of evaluation of the request. A deeper focus on unbearable suffering, decision capacity and possibilities of improvements is warranted as well as the involvement of mental health professionals.

Published
2021

4. Increased sense of identity in delusional disorders

Author

Noel-Jorand, M.C., Reinert, M., Giudicelli, S., and Dassa, D.

Subjects
Delusional disorder -- Care and treatment, Identity, Psychology and mental health
Abstract

Language, which is unique in each subject, can reflect how a patient copes with disease. The method ALCESTE used here made it possible at the same time to analyse the subject's verbal behavior and speech patterns at several levels. The present study was designed to analyse during a 3-mo. period the language production of subjects with paranoia exhibiting delusional disorder (nonbizarre delusions without any hallucination) of imaginative subtype. The subjects produced very specific speech without any semantic or syntactic impairment and disruption in language or thinking processes, but with a poverty of speech content. The main feature of the study was the analysis of the underlying syntactic processes showing that the tested patients presented a 'hard' sense of identity: the patient found always a strong place for himself among the various types of discourse whatever their topics.

Published
2004

8. Anhedonia is associated with suicidal ideation independently of depression: A meta-analysis

Author

Ducasse, D., Loas, Gwenolé, Dassa, D., Gramaglia, C., Zeppegno, P., Guillaume, S, Olié, E., Courtet, P., Ducasse, D., Loas, Gwenolé, Dassa, D., Gramaglia, C., Zeppegno, P., Guillaume, S, Olié, E., and Courtet, P.

Abstract

Background: Anhedonia is considered a suicide risk factor in patients with major affective disorders. Here, we wanted to quantify the association between anhedonia and current suicidal ideation according to the absence/presence of between-group differences for depressive scores and psychiatric disorders. Methods: We performed a meta-analysis of data on studies retrieved from Medline, Web of Science, and PsycINFO from 1965 to 2016 using, among others, the terms (suicid* or depression) and anhedonia. Results: We identified 15 observational case–control studies that investigated the anhedonia differences in individuals with and without current (i.e. within the past week, independently of the lifetime suicidality status) suicidal ideation (defined as thoughts of killing oneself). Overall, 657 subjects with and 6,690 subjects without current suicidal ideation could be compared. Anhedonia level was higher in the group with current suicidal ideation than in the group without, with a medium effect size (standardized mean difference = 0.57, z = 5.43, P < 0.001, 95% confidence interval, CI = 0.37–0.79). The association between anhedonia and current suicidal ideation remained significant when controlling for depression and psychiatric disorders. The anhedonia scales used in the selected studies did not allow investigating consummatory and motivational anhedonia separately. Conclusion: Our major finding is the robust association between anhedonia and current suicidal ideation, independently of depression. This is highly relevant for the clinicians’ daily practice and might help improving suicidal risk detection and the development of new therapeutic strategies for suicide prevention., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2018

10. [Pathophysiological models of mixed states]

Author

Belzeaux, R., Ibrahim, E. C., Azorin, J.-M., Fakra, E., Maurel, M., Pringuey, D., Kaladjian, A., Dassa, D., Corréard, N., Dubois, Emeric, Micoulaud-Franchi, Jean-Arthur, Cermolacce, M., Neurobiologie des interactions cellulaires et neurophysiopathologie - NICN (NICN), Centre National de la Recherche Scientifique (CNRS)-Université de la Méditerranée - Aix-Marseille 2, Pôle psychiatrique Centre, Assistance Publique - Hôpitaux de Marseille (APHM)-Hôpital de la Conception [CHU - APHM] (LA CONCEPTION), Centre de recherche en neurobiologie - neurophysiologie de Marseille (CRN2M), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Clinique de Psychiatrie et de Psychologie Médicale, Hôpital Pasteur, Nice, France, Centre Hospitalier Universitaire de Nice (CHU Nice), Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF), Institut de neurosciences cognitives de la méditerranée - UMR 6193 (INCM), and Université de la Méditerranée - Aix-Marseille 2-Centre National de la Recherche Scientifique (CNRS)

Subjects
Suicide Prevention, Depressive Disorder, Major, Bipolar Disorder, Substance-Related Disorders, Dopamine, Models, Neurological, Brain, Comorbidity, Anxiety Disorders, Personality Disorders, Thyroid Diseases, behavioral disciplines and activities, Diagnostic and Statistical Manual of Mental Disorders, Affect, Suicide, mental disorders, Humans, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], Arousal, Temperament
Abstract

International audience; Mixed states are complex manifestations of bipolar disorders. Pathophysiology of mixed states remains unclear. Several models have been proposed to understand the mechanisms underlying these mood states. These models describe mixed state either as a combinaison of depression and mania, as well as a transition between mania and depression, or mixed state as a severe type of depression or mania. Pathophysiological hypotheses involve temperaments or some personality disorders, psychiatric comorbidities as well as substance use disorders, or thyroid dysfunction. However, the formal demonstration of any specific genetic vulnerability to mixed state has not yet been provided.

Published
2013

12. Short history of mixed states

Author

Cermolacce, M., Belzeaux, R., Correard, N., Dassa, D., Dubois, M., Micoulaud-Franchi, J. -A, Pringuey, D., Fakra, E., Maurel, M., Azorin, J. -M., Institut de neurosciences cognitives de la méditerranée - UMR 6193 (INCM), Université de la Méditerranée - Aix-Marseille 2-Centre National de la Recherche Scientifique (CNRS), Neurobiologie des interactions cellulaires et neurophysiopathologie - NICN (NICN), Pôle psychiatrique Centre, Assistance Publique - Hôpitaux de Marseille (APHM)-Hôpital de la Conception [CHU - APHM] (LA CONCEPTION), Centre de recherche en neurobiologie - neurophysiologie de Marseille (CRN2M), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Clinique de Psychiatrie et de Psychologie Médicale, Hôpital Pasteur, Nice, France, Centre Hospitalier Universitaire de Nice (CHU Nice), and Centre National de la Recherche Scientifique (CNRS)-Université de la Méditerranée - Aix-Marseille 2

Subjects
[SCCO]Cognitive science, [SCCO.NEUR]Cognitive science/Neuroscience, ComputingMilieux_MISCELLANEOUS
Abstract

International audience; no abstract

Published
2013

14. Clinique des manies mixtes

Author

Maurel, M., primary, Belzeaux, R., additional, Fakra, E., additional, Cermolacce, M., additional, Dassa, D., additional, Dubois, M., additional, Micoulaud Franchi, J.-A., additional, Corréard, N., additional, and Azorin, J.-M., additional

Published
2013
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16. Le traitement des dépressions mixtes

Author

Dubois, M., primary, Dassa, D., additional, Belzeaux, R., additional, Fakra, E., additional, Cermolacce, M., additional, Corréard, N., additional, Kaladjian, A., additional, and Azorin, J.-M., additional

Published
2013
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18. Modèles physiopathologiques des états mixtes

Author

Belzeaux, R., primary, Ibrahim, E.C., additional, Azorin, J.-M., additional, Fakra, E., additional, Maurel, M., additional, Pringuey, D., additional, Kaladjian, A., additional, Dassa, D., additional, Corréard, N., additional, Dubois, E., additional, Micoulaud-Franchi, J.-A., additional, and Cermolacce, M., additional

Published
2013
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19. Une approche historique des états mixtes

Author

Cermolacce, M., primary, Belzeaux, R., additional, Corréard, N., additional, Dassa, D., additional, Dubois, M., additional, Micoulaud-Franchi, J.-A., additional, Pringuey, D., additional, Fakra, E., additional, Maurel, M., additional, and Azorin, J.-M., additional

Published
2013
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21. États mixtes. Évolution des classifications

Author

Pringuey, D., primary, Cherikh, F., additional, Giordana, B., additional, Fakra, E., additional, Dassa, D., additional, Cermolacce, M., additional, Belzeaux, R., additional, Maurel, M., additional, and Azorin, J.-M., additional

Published
2013
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23. Professionals' Satisfaction Questionnaire with Electronic Medical Records

Author

Boyer, L., primary, Baumstarck-Barrau, K., additional, Belzeaux, R., additional, Azorin, J.M., additional, Chabannes, J.M., additional, Dassa, D., additional, Lancon, C., additional, Naudin, J., additional, Poinso, F., additional, Rufo, M., additional, Samuelian, J.C., additional, Loundou, A., additional, Fieschi, M., additional, and Auquier, P., additional

Published
2011
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25. Validation of a Professionals’ Satisfaction Questionnaire with Electronic Medical Records (PSQ-EMR) in Psychiatry

Author

Boyer, L., primary, Baumstarck-Barrau, K., additional, Belzeaux, R., additional, Azorin, J.M., additional, Chabannes, J.M., additional, Dassa, D., additional, Lancon, C., additional, Naudin, J., additional, Poinso, F., additional, Rufo, M., additional, Samuelian, J.C., additional, Loundou, A., additional, Fieschi, M., additional, and Auquier, P., additional

Published
2010
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29. Mes de nacimiento en pacientes esquizofrénicos con y sin déficit

Author

Dollfus, S., primary, Brazo, P., additional, Langlois, S., additional, Gourevitch, R., additional, Dassa, D., additional, Besse, F., additional, Van Der Elst, A., additional, Thibaut, F., additional, Delamillieure, P., additional, Chabot, B., additional, Guelfi, J. D., additional, and Petit, M., additional

Published
2000
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31. Month of birth in deficit and non-deficit schizophrenic patients

Author

Dollfus, S., primary, Brazo, P., additional, Langlois, S., additional, Gourevitch, R., additional, Dassa, D., additional, Besse, F., additional, Van Der Elst, A., additional, Thibaut, F., additional, Delamillieure, P., additional, Chabot, B., additional, Guelfi, J.D., additional, and Petit, M., additional

Published
1999
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32. Season of birth and bipolar disorder

Author

Dassa D and Azorin Jm

Subjects
Psychiatry and Mental health, Season of birth, business.industry, Medicine, Bipolar disorder, business, medicine.disease, Demography
Published
1993

33. Deficit and negative subtypes in schizophrenia: Clinical and biological differences

Author

Dollfus, S., primary, Brazo, P., additional, Nkam, I., additional, Thibaut, F., additional, Moity, F., additional, Langlois, S., additional, Gourrevitch, R., additional, Dassa, D., additional, Denise, P., additional, Levillain, D., additional, Halbecq, I., additional, Delamillieure, P., additional, Van Der Elst, A., additional, Segard, L., additional, Assouly-Besse, F., additional, Vasse, T., additional, Etard, O., additional, Guelfi, J.D., additional, Launay, C., additional, Petitjean, F., additional, and Petit, M., additional

Published
1998
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44. Frequent visits to a French psychiatric emergency service: diagnostic variability in psychotic disorders.

Author

Boyer L, Dassa D, Belzeaux R, Henry JM, Samuelian JC, Baumstarck-Barrau K, Lancon C, Boyer, Laurent, Dassa, Daniel, Belzeaux, Raoul, Henry, Jean-Marc, Samuelian, Jean-Claude, Baumstarck-Barrau, Karine, and Lancon, Christophe

Abstract

Objective: This study examined characteristics of frequent visitors to a psychiatric emergency service in a French public teaching hospital over six years. Diagnostic variability of psychotic disorders was documented.Methods: A retrospective review of the service's administrative and medical databases identified 1,285 patients with more than one visit during the period who were given at least one diagnosis of a psychotic disorder. A total of 317 patients with six or more visits (frequent visitors) were compared with 968 patients with between two and five visits (occasional visitors).Results: Frequent visitors were significantly more likely to be single and homeless and to have diagnostic variability, substance use disorders, and personality disorders. A total of 177 patients experienced diagnostic variability, which was found mainly in three diagnostic categories: schizophrenia, schizoaffective disorder, and bipolar disorder with psychotic features.Conclusions: Future studies should further examine the link between increased use of emergency services and diagnostic variability. [ABSTRACT FROM AUTHOR]

Published
2011
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50. Evidence for a defective platelet Ltryptophan transport in depressed patients

Author

Gronier, B., Azorin, J. M., Dassa, D., and Jeanningros, R.

Abstract

The kinetic characteristics of platelet L-tryptophan uptake were investigated in 23 untreated depressed patients and 18 healthy volunteers. A significant increase of 50 in the apparent Michaelis constant (Km) was observed in depressed patients compared with controls, without significant change in the maximal velocity (Vmax). After 1 month of successful antidepressant treatment the mean Kmvalue decreased significantly and reached the control value. This result raises the possibility that the decrease in platelet tryptophan uptake affinity is a state-dependent marker for depression. It is likely that the transport alteration results in a decrease in platelet tryptophan accumulation. The effect of this peripheral membrane defect on brain serotonin function is discussed.

Published
1993

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