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2 results on '"Daud Allajar"'

1. Clip placement to prevent delayed bleeding after colonic endoscopic mucosal resection (CLIPPER): study protocol for a randomized controlled trial

Author

Ayla S. Turan, Leon M. G. Moons, Ramon-Michel Schreuder, Erik J. Schoon, Jochim S. Terhaar sive Droste, Ruud W. M. Schrauwen, Jan Willem Straathof, Barbara A. J. Bastiaansen, Matthijs P. Schwartz, Wouter L. Hazen, Alaa Alkhalaf, Daud Allajar, Muhammed Hadithi, Bas W. van der Spek, Dimitri G. D. N. Heine, Adriaan C. I. T. L. Tan, Wilmar de Graaf, Jurjen J. Boonstra, Fia J. Voogd, Robert Roomer, Rogier J. J. de Ridder, Wietske Kievit, Peter D. Siersema, Paul Didden, Erwin J. M. van Geenen, and on behalf of the Dutch EMR Study Group

Subjects
Prophylactic clipping, EMR, Colonic polyp, Delayed bleeding, Clip artifact, Medicine (General), R5-920
Abstract

Abstract Background Endoscopic mucosal resection (EMR) for large colorectal polyps is in most cases the preferred treatment to prevent progression to colorectal carcinoma. The most common complication after EMR is delayed bleeding, occurring in 7% overall and in approximately 10% of polyps ≥ 2 cm in the proximal colon. Previous research has suggested that prophylactic clipping of the mucosal defect after EMR may reduce the incidence of delayed bleeding in polyps with a high bleeding risk. Methods The CLIPPER trial is a multicenter, parallel-group, single blinded, randomized controlled superiority study. A total of 356 patients undergoing EMR for large (≥ 2 cm) non-pedunculated polyps in the proximal colon will be included and randomized to the clip group or the control group. Prophylactic clipping will be performed in the intervention group to close the resection defect after the EMR with a distance of

Published
2021
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2. Plasma asymmetric dimethylarginine (ADMA) concentration is independently associated with carotid intima-media thickness and plasma soluble vascular cell adhesion molecule-1 (sVCAM-1) concentration in patients with mild-to-moderate renal failure

Author

Annemieke M.W. Spijkerman, Prabath W. B. Nanayakkara, Casper G. Schalkwijk, T. Teerlink, Daud Allajar, Piet M. ter Wee, Coen van Guldener, Coen D.A. Stehouwer, Internal medicine, Laboratory Medicine, Human genetics, Nephrology, Interne Geneeskunde, RS: NUTRIM School of Nutrition and Translational Research in Metabolism, and RS: CARIM School for Cardiovascular Diseases

Subjects
Nephrology, Adult, Carotid Artery Diseases, Male, medicine.medical_specialty, renal failure, asymmetric dimethylarginine, Renal function, Vascular Cell Adhesion Molecule-1, Arginine, Kidney, Antioxidants, C-reactive protein, chemistry.chemical_compound, Internal medicine, Blood plasma, medicine, Humans, intima-media thickness, Homocysteine, Aged, Ultrasonography, Creatinine, business.industry, soluble vascular cell adhesion molecule-1, creatinine, Middle Aged, medicine.disease, Oxidative Stress, Endocrinology, chemistry, Intima-media thickness, Solubility, Renal physiology, Kidney Failure, Chronic, Female, Asymmetric dimethylarginine, business, Tunica Intima, Tunica Media, Biomarkers, Kidney disease
Abstract

Plasma asymmetric dimethylarginine (ADMA) concentration is independently associated with carotid intima-media thickness and plasma soluble vascular cell adhesion molecule-1 (sVCAM-1) concentration in patients with mild-to-moderate renal failure. Background. Patients with renal insufficiency have an increased risk of cardiovascular disease that is not fully explained by the presence of known cardiovascular risk factors. In patients with end-stage renal disease, increased serum concentration of asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase (NOS), has been linked to excess cardiovascular morbidity. We investigated, in patients with mild-to-moderate renal failure, the relationship between plasma ADMA and three surrogate markers of atherosclerosis that have been shown to have prognostic value, namely carotid intima-media thickness (IMT), plasma soluble vascular cell adhesion molecule-1 (sVCAM-1), and plasma C-reactive protein (CRP). Methods. We used baseline data of an ongoing randomized trial in which the effects of oxidative stress-lowering treatment on vascular function and structure are studied in patients with chronic nondiabetic renal failure without clinical evidence of atherosclerosis (GFR 15 to 70 mL/min/per 1.73m(2) according to the Cockcroft-Gault equation; ATIC study). Results. Data from 93 patients were used. Creatinine clearance was inversely related to plasma ADMA concentration (standardized beta after adjustment =-0.342, P= 0.023). Plasma ADMA was strongly related to carotid IMT in univariate (beta= 0.459, P

Published
2005
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