1. Treatments for microcystic adnexal carcinoma--A review.
- Author
-
Chaudhari SP, Mortazie MB, Blattner CM, Garelik J, Wolff M, Daulat J, and Chaudhari PJ
- Subjects
- Antineoplastic Agents therapeutic use, Humans, Mohs Surgery, Neoplasm Recurrence, Local pathology, Radiotherapy, Skin Neoplasms drug therapy, Skin Neoplasms pathology, Skin Neoplasms radiotherapy, Skin Neoplasms surgery, Sweat Gland Neoplasms drug therapy, Sweat Gland Neoplasms pathology, Sweat Gland Neoplasms radiotherapy, Sweat Gland Neoplasms surgery, Skin Neoplasms therapy, Sweat Gland Neoplasms therapy
- Abstract
Introduction: Microcystic adnexal carcinoma (MAC) is a rare malignant cutaneous neoplasm presenting as a slow-growing, indurated nodule, papule or plaque. Clinically, the lesion can blend into the surrounding skin, obscuring borders and consequently delaying diagnosis histologically. Surgical and histologic techniques that emphasize examination of all margins may optimize management through early diagnosis and prevention of recurrences., Objective: This review aims to assess the current surgical and histology techniques that result in lower rates of tumor recurrence and, consequently, better clinical outcomes., Methods: A literature search of the PubMed database was conducted to identify studies examining wide local excision (WLE), Mohs micrographic surgery (MMS), radiotherapy (RT) and chemotherapy in the treatment of MAC., Results: WLE had a high likelihood of positive margins and local recurrence. MMS was found to have the lowest recurrence rates. Definitive RT could be considered for elderly patients or those who are poor surgical candidates, as large surgical defects may be required to obtain free margins with either WLE or MMS. Chemotherapy was found to be ineffective., Conclusion: Complete margin evaluation with MMS permits complete tumor removal with subsequently low recurrence rate.
- Published
- 2016
- Full Text
- View/download PDF