100 results on '"Davì, S"'
Search Results
2. Immunotherapy Plus Chemotherapy Versus Chemotherapy Alone as First-Line Treatment for Advanced Urothelial Cancer: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials
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Mamede, Isadora, Escalante-Romero, Lorena, Celso, Davi S. Gonçalves, Reis, Pedro C. Abrahao, Dacoregio, Maria Inez, Alves, Ana Caroline, and Stecca, Carlos
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- 2024
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3. Anxiogenic doses of rapamycin prevent URB597-induced anti-stress effects in socially defeated mice
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Fusse, Eduardo J., Scarante, Franciele F., Vicente, Maria A., Marrubia, Mariana M., Turcato, Flávia, Scomparin, Davi S., Ribeiro, Melissa A., Figueiredo, Maria J., Brigante, Tamires A.V., Guimarães, Francisco S., and Campos, Alline C.
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- 2024
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4. Acidity modulation of Pt-supported catalyst enhances C-O bond cleavage over acetone hydrodeoxygenation
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Strapasson, Guilherme B., Sousa, Leonardo S., Báfero, Gabriel B., Leite, Davi S., Moreno, Beatriz D., Rodella, Cristiane B., and Zanchet, Daniela
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- 2023
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5. Musculoskeletal manifestations of childhood cancer and differential diagnosis with juvenile idiopathic arthritis (ONCOREUM): a multicentre, cross-sectional study
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Amatruda, M, Atzeni, C, Bertolini, P, Bigucci, B, Caniglia, M, Cappella, M, Cattalini, M, Cefalo, MG, Cellini, M, Cortis, E, Davì, S, De Benedetti, F, Di Cataldo, A, Fabbri, E, Fagioli, F, Fontanili, I, Garaventa, A, Gicchino, MF, Ladogana, S, Locatelli, F, Magnolato, A, Marsili, M, Martino, S, Mascarin, M, Messina, C, Micalizzi, C, Porta, F, Rizzari, C, Civino, Adele, Alighieri, Giovanni, Prete, Eleonora, Caroleo, Anna Maria, Magni-Manzoni, Silvia, Vinti, Luciana, Romano, Micol, Santoro, Nicola, Filocamo, Giovanni, Belotti, Tamara, Santarelli, Francesca, Gorio, Chiara, Ricci, Francesca, Colombini, Antonella, Pastore, Serena, Cesaro, Simone, Barone, Patrizia, Verzegnassi, Federico, Olivieri, Alma Nunzia, Ficara, Monica, Miniaci, Angela, Russo, Giovanna, Gallizzi, Romina, Pericoli, Roberta, Breda, Luciana, Mura, Rossella, Podda, Rosa Anna, Onofrillo, Daniela, Lattanzi, Bianca, Tirtei, Elisa, Maggio, Maria Cristina, De Santis, Raffaela, Consolini, Rita, Arlotta, Annalisa, La Torre, Francesco, Mainardi, Chiara, Pelagatti, Maria Antonietta, Coassin, Elisa, Capolsini, Ilaria, Burnelli, Roberta, Tornesello, Assunta, Soscia, Francesca, De Fanti, Alessandro, Rigante, Donato, Pizzato, Cristina, De Fusco, Carmela, Abate, Massimo Eraldo, Roncadori, Andrea, Rossi, Elisa, Stabile, Giulia, Biondi, Andrea, Lepore, Loredana, Conter, Valentino, Rondelli, Roberto, Pession, Andrea, and Ravelli, Angelo
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- 2021
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6. Bound vortex states and exotic lattices in multi-component Bose-Einstein condensates: The role of vortex-vortex interaction
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Dantas, Davi S., Lima, Aristeu R. P., Chaves, A., Almeida, C. A. S., Farias, G. A., and Milošević, M. V.
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Condensed Matter - Quantum Gases ,Physics - Atomic Physics - Abstract
We numerically study the vortex-vortex interaction in multi-component homogeneous Bose-Einstein condensates within the realm of the Gross-Pitaevskii theory. We provide strong evidences that pairwise vortex interaction captures the underlying mechanisms which determine the geometric configuration of the vortices, such as different lattices in many-vortex states, as well as the bound vortex states with two (dimer) or three (trimer) vortices. Specifically, we discuss and apply our theoretical approach to investigate intra- and inter-component vortex-vortex interactions in two- and three-component Bose-Einstein condensates, thereby shedding light on the formation of the exotic vortex configurations. These results correlate with current experimental efforts in multi-component Bose-Einstein condensates, and the understanding of the role of vortex interactions in multiband superconductors., Comment: Published in PRA
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- 2015
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7. Comparative Evaluation of Large Language Models As Clinical Decision Support Tool for Cardiac Amyloidosis
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Azevedo, Giovane L., Potsch, Breno P., Yahiro, Davi S., Ávila, Luiza A., Freitas, Luiza M.R. S., Lutterbach, Vinícius A.M., and Mesquita, Claudio T.
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- 2024
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8. Regional vs. Global Myocardial Flow Reserve Discordance in CZT SPECT: Implications for Risk Stratification
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Mesquita, Claudio T., Palazzo, Isabella C., Azevedo, Giovane L., Ker, Wilter, Yahiro, Davi S., Chambi, Alan, Santos, Roberta, Sabra, Maria Marta, and Correa, Nilton
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- 2024
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9. Enhancing Risk Stratification: Myocardial Flow Reserve Assessment via CZT SPECT Identifies High-Risk Patients With Normal Myocardial Perfusion Imaging SPECT
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Palazzo, Isabella C., Correa, Nilton, Azevedo, Giovane L., Yahiro, Davi S., Ker, Wilter, Chambi, Alan, Sabra, Maria Marta, Santos, Roberta, and Mesquita, Claudio T.
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- 2024
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10. Comparative Evaluation of Large Language Models for Patient Guidance on Pyrophosphate Scintigraphy Results
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Azevedo, Giovane L., Potsch, Breno P., Yahiro, Davi S., Ávila, Luiza A., Freitas, Luiza M.R.S., Lutterbach, Vinícius A.M., and Mesquita, Claudio T.
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- 2024
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11. Microwave-assisted solvothermal synthesis of In-MIL-68 derived hollow In2O3 microrods for enhanced 1-pentanol sensing performance
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de Sá, Bruna S., Perfecto, Tarcísio M., de Oliveira, Davi S., and Volanti, Diogo P.
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- 2023
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12. Influence of low velocity impact on fatigue behaviour of woven hemp fibre reinforced epoxy composites
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de Vasconcellos, Davi S., Sarasini, Fabrizio, Touchard, Fabienne, Chocinski-Arnault, Laurence, Pucci, Monica, Santulli, Carlo, Tirillò, Jacopo, Iannace, Salvatore, and Sorrentino, Luigi
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- 2014
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13. Synergistic action of co-expressed xylanase/laccase mixtures against milled sugar cane bagasse
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Fonseca-Maldonado, Raquel, Ribeiro, Lucas F., Furtado, Gilvan P., Arruda, Letícia M., Meleiro, Luana P., Alponti, Juliana S., Botelho-Machado, Carla, Vieira, Davi S., Bonneil, Eric, Furriel, Rosa dos Prazeres Melo, Thibault, Pierre, and Ward, Richard J.
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- 2014
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14. Tension–tension fatigue behaviour of woven hemp fibre reinforced epoxy composite: A multi-instrumented damage analysis
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de Vasconcellos, Davi S., Touchard, Fabienne, and Chocinski-Arnault, Laurence
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- 2014
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15. Macrophage Activation Syndrome
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Ravelli, A., primary, Minoia, F., additional, Davì, S., additional, and Martini, A., additional
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- 2016
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16. Musculoskeletal manifestations of childhood cancer and differential diagnosis with juvenile idiopathic arthritis (ONCOREUM): a multicentre, cross-sectional study
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Civino, Adele, primary, Alighieri, Giovanni, additional, Prete, Eleonora, additional, Caroleo, Anna Maria, additional, Magni-Manzoni, Silvia, additional, Vinti, Luciana, additional, Romano, Micol, additional, Santoro, Nicola, additional, Filocamo, Giovanni, additional, Belotti, Tamara, additional, Santarelli, Francesca, additional, Gorio, Chiara, additional, Ricci, Francesca, additional, Colombini, Antonella, additional, Pastore, Serena, additional, Cesaro, Simone, additional, Barone, Patrizia, additional, Verzegnassi, Federico, additional, Olivieri, Alma Nunzia, additional, Ficara, Monica, additional, Miniaci, Angela, additional, Russo, Giovanna, additional, Gallizzi, Romina, additional, Pericoli, Roberta, additional, Breda, Luciana, additional, Mura, Rossella, additional, Podda, Rosa Anna, additional, Onofrillo, Daniela, additional, Lattanzi, Bianca, additional, Tirtei, Elisa, additional, Maggio, Maria Cristina, additional, De Santis, Raffaela, additional, Consolini, Rita, additional, Arlotta, Annalisa, additional, La Torre, Francesco, additional, Mainardi, Chiara, additional, Pelagatti, Maria Antonietta, additional, Coassin, Elisa, additional, Capolsini, Ilaria, additional, Burnelli, Roberta, additional, Tornesello, Assunta, additional, Soscia, Francesca, additional, De Fanti, Alessandro, additional, Rigante, Donato, additional, Pizzato, Cristina, additional, De Fusco, Carmela, additional, Abate, Massimo Eraldo, additional, Roncadori, Andrea, additional, Rossi, Elisa, additional, Stabile, Giulia, additional, Biondi, Andrea, additional, Lepore, Loredana, additional, Conter, Valentino, additional, Rondelli, Roberto, additional, Pession, Andrea, additional, Ravelli, Angelo, additional, Amatruda, M, additional, Atzeni, C, additional, Bertolini, P, additional, Bigucci, B, additional, Caniglia, M, additional, Cappella, M, additional, Cattalini, M, additional, Cefalo, MG, additional, Cellini, M, additional, Cortis, E, additional, Davì, S, additional, De Benedetti, F, additional, Di Cataldo, A, additional, Fabbri, E, additional, Fagioli, F, additional, Fontanili, I, additional, Garaventa, A, additional, Gicchino, MF, additional, Ladogana, S, additional, Locatelli, F, additional, Magnolato, A, additional, Marsili, M, additional, Martino, S, additional, Mascarin, M, additional, Messina, C, additional, Micalizzi, C, additional, Porta, F, additional, and Rizzari, C, additional
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- 2021
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17. A prediction rule for polyarticular extension in oligoarticular-onset juvenile idiopathic arthritis
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Schiappapietra, B., Bava, C., Rosina, S., Pistorio, A., Mongelli, F., Pederzoli, S., Verazza, S., Lanni, S., Muratore, V., Davì, S., Dalprà, S., Varnier, G. C., Marta Bertamino, Suffia, C., Bracciolini, G., Giancane, G., Consolaro, A., and Ravelli, A.
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Logistic Models ,Rheumatology ,Antibodies, Antinuclear ,Antinuclear ,Arthritis ,Immunology ,Immunology and Allergy ,Humans ,Juvenile ,Child ,Arthritis, Juvenile ,Antibodies - Abstract
To search for predictors of polyarticular extension in children with oligoarticular-onset juvenile idiopathic arthritis (JIA) and to develop a prediction model for an extended course.The clinical charts of consecutive patients with oligoarticular-onset JIA and ≥2 years of disease duration were reviewed. Predictor variables included demographic data, number and type of affected joints, presence of iridocyclitis, laboratory tests including antinuclear antibodies, and therapeutic interventions in the first 6 months. Joint examinations were evaluated to establish whether after the first 6 months of disease patients had persistent or extended course (i.e. involvement of 4 or less, or 5 or more joints). Statistics included univariable and multivariable analyses. Regression coefficients (β) of variables that entered the best-fitting logistic regression model were converted and summed to obtain a "prediction score" for an extended course.A total of 480 patients with a median disease duration of 7.4 years were included. 61.2% had persistent oligoarthritis, whereas 38.8% experienced polyarticular extension. On multivariable analysis, independent correlations with extended course were identified for the presence of ≥2 involved joints and a CRP0.8 mg/dl in the first 6 months. The prediction score ranged from 0 to 6 and its cut-off that discriminated best between patients who had or did not have polyarticular extension was1. Sensitivity and specificity were 59.6 and 79.8, respectively.The number of affected joints and the CRP level in the first 6 months were the strongest predictors of polyarticular extension in our children with oligoarticular-onset JIA.
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- 2021
18. Agreement between objective and subjective definitions of inactive disease, remission and minimal disease activity in juvenile idiopathic arthritis
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Davì S, Lanni S, Solari N, Magni-Manzoni S, Consolaro A, Schiappapietra B, Pederzoli S, Bracciolini G, Martini A, and Ravelli A
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Pediatrics ,RJ1-570 ,Diseases of the musculoskeletal system ,RC925-935 - Published
- 2011
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19. Comparison of physician's, parent's and patient's global ratings made on linear or 21-circle visual analogue scales (VAS) in juvenile idiopathic arthritis (JIA)
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Dalprà S, Verazza S, Ferrari C, Parodi A, Davì S, Schiappapietra B, Consolaro A, Filocamo G, Viola S, Martini A, and Ravelli A
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Pediatrics ,RJ1-570 ,Diseases of the musculoskeletal system ,RC925-935 - Published
- 2008
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20. Comparison of the accuracy of different definitions of clinical remission (CR) and minimal disease activity (MDA) in juvenile idiopathic arthritis (JIA)
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Davì S, Consolaro A, Ferrari C, Federici S, Vitale R, Filocamo G, Loy A, Ruperto N, Martini A, and Ravelli A
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Pediatrics ,RJ1-570 ,Diseases of the musculoskeletal system ,RC925-935 - Published
- 2008
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21. Etanercept efficacy in the treatment of chronic isolated inflammatory coxitis
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Parodi A, Picco P, Malattia C, Davì S, Dalprà S, Traverso F, Ponti MC, Buoncompagni A, Loy A, Viola S, and Martini A
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Pediatrics ,RJ1-570 ,Diseases of the musculoskeletal system ,RC925-935 - Published
- 2008
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22. Correction of B-scan distortion for optimum ultrasonic imaging of backwalls with complex geometries
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Davì, S, primary, Mineo, C, additional, MacLeod, C, additional, Pierce, S G, additional, Gachagan, A, additional, Paton, S, additional, Munro, G, additional, O'Brien-O'Reilly, J, additional, and McCubbin, C, additional
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- 2020
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23. Development and Initial Validation of the MS Score for Diagnosis of Macrophage Activation Syndrome in Systemic Juvenile Idiopathic Arthritis
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Minoia, F, Bovis, F, Davì, S, Horne, A, Fischbach, M, Frosch, M, Huber, A, Jelusic, M, Sawhney, S, Mccurdy, D, Silva, Ca, Rigante, Donato, Unsal, E, Ruperto, N, Martini, A, Cron, R, Ravelli, A, Rigante, D (ORCID:0000-0001-7032-7779), Minoia, F, Bovis, F, Davì, S, Horne, A, Fischbach, M, Frosch, M, Huber, A, Jelusic, M, Sawhney, S, Mccurdy, D, Silva, Ca, Rigante, Donato, Unsal, E, Ruperto, N, Martini, A, Cron, R, Ravelli, A, and Rigante, D (ORCID:0000-0001-7032-7779)
- Abstract
The paper describes the assessment and validation process for the MS score to diagnose macrophage activation syndrome in children with systemic juvenile idiopathic arthritis
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- 2019
24. Targeted next-generation sequencing helps to decipher the genetic and phenotypic heterogeneity of hypertrophic cardiomyopathy
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Cecconi, M., Parodi, M. I., Formisano, F., Spirito, P., Autore, C., Musumeci, M. B., Favale, S., Forleo, C., Rapezzi, C., Biagini, E., Davì, S., Canepa, E., Pennese, L., Castagnetta, M., Degiorgio, Dario, Coviello, Domenico, Collaborative Working Group, Cecconi, Massimiliano, Parodi, Maria I., Formisano, Francesco, Spirito, Paolo, Autore, Camillo, Musumeci, Maria B., Favale, Stefano, Forleo, Cinzia, Rapezzi, Claudio, Biagini, Elena, Davì, Sabrina, Canepa, Elisabetta, Pennese, Loredana, Castagnetta, Mauro, Degiorgio, Dario, and Coviello, Domenico A.
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0301 basic medicine ,Arrhythmias ,030204 cardiovascular system & hematology ,medicine.disease_cause ,Non-sarcomeric genes ,Genetic heterogeneity ,0302 clinical medicine ,Myofibrils ,Borderline HCM ,Hypertrophic cardiomyopathy ,Ion Torrent Personal Genome Machine ,Next-generation sequencing ,Phenotypic heterogeneity ,Thick/intermediate and thin myofilament proteins ,Adolescent ,Adult ,Aged ,Arrhythmias, Cardiac ,Cardiomyopathy, Hypertrophic ,Child ,Child, Preschool ,Exons ,High-Throughput Nucleotide Sequencing ,Humans ,Middle Aged ,Mutation ,Phenotype ,Syndrome ,Young Adult ,Genetics ,Non-sarcomeric gene ,Sanger sequencing ,Thick/intermediate and thin myofilament protein ,Articles ,General Medicine ,Myosin binding ,symbols ,Cardiac ,Cardiomyopathy ,Biology ,DNA sequencing ,NO ,03 medical and health sciences ,symbols.namesake ,medicine ,cardiovascular diseases ,Preschool ,Gene ,Phenocopy ,Ion Torrent Personal Genome Machine, borderline HCM, hypertrophic cardiomyopathy, next-generation sequencing, thick/intermediate and thin myofilament proteins, non-sarcomeric genes, genetic heterogeneity, phenotypic heterogeneity ,030104 developmental biology ,Hypertrophic ,MYH7 - Abstract
Hypertrophic cardiomyopathy (HCM) is mainly associated with myosin, heavy chain 7 (MYH7) and myosin binding protein C, cardiac (MYBPC3) mutations. In order to better explain the clinical and genetic heterogeneity in HCM patients, in this study, we implemented a target-next generation sequencing (NGS) assay. An Ion AmpliSeq™ Custom Panel for the enrichment of 19 genes, of which 9 of these did not encode thick/intermediate and thin myofilament (TTm) proteins and, among them, 3 responsible of HCM phenocopy, was created. Ninety-two DNA samples were analyzed by the Ion Personal Genome Machine: 73 DNA samples (training set), previously genotyped in some of the genes by Sanger sequencing, were used to optimize the NGS strategy, whereas 19 DNA samples (discovery set) allowed the evaluation of NGS performance. In the training set, we identified 72 out of 73 expected mutations and 15 additional mutations: the molecular diagnosis was achieved in one patient with a previously wild-type status and the pre-excitation syndrome was explained in another. In the discovery set, we identified 20 mutations, 5 of which were in genes encoding non-TTm proteins, increasing the diagnostic yield by approximately 20%: a single mutation in genes encoding non-TTm proteins was identified in 2 out of 3 borderline HCM patients, whereas co-occuring mutations in genes encoding TTm and galactosidase alpha (GLA) altered proteins were characterized in a male with HCM and multiorgan dysfunction. Our combined targeted NGS-Sanger sequencing-based strategy allowed the molecular diagnosis of HCM with greater efficiency than using the conventional (Sanger) sequencing alone. Mutant alleles encoding non-TTm proteins may aid in the complete understanding of the genetic and phenotypic heterogeneity of HCM: co-occuring mutations of genes encoding TTm and non-TTm proteins could explain the wide variability of the HCM phenotype, whereas mutations in genes encoding only the non-TTm proteins are identifiable in patients with a milder HCM status.
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- 2016
25. Association of kidney disease measures with risk of renal function worsening in patients with type 1 diabetes 11 Medical and Health Sciences 1103 Clinical Sciences
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Mirijello, Antonio, Viazzi, Francesca, Fioretto, Paola, Giorda, C. B., Ceriello, Antonio, Russo, Giuspina T., Guida, Pietro, Pontremoli, Roberto, De Cosmo, S., Cimino, Antonino, Fava, Danila, Meloncelli, Illidio, Nicolucci, Antonio, Pellegrini, Fabio, Rossi, Maria Chiara, Turco, Salvatore, Vespasiani, Giacomo, Graziano, G., Lucisano, G., Memmo, R., Pellicciotta, E., Paciotti, V., Pupillo, M., Armentano, G., Giovannini, C., Armentano, V., Laudato, M., Acquati, S., Ciardullo, A. V., Laffi, G., Felace, G., Taboga, C., Tortul, C., Santantonio, G., Suraci, C., Ghisoni, G., Raffa, M., Genovese, S., Lovagnini-Scher, C. A., Rampini, P., Rocca, A., Ruggeri, P., Tortato, E., Cotti, L., Cristofaro, M. R., Tagliaferri, M., Comoglio, M., Fornengo, R., Gentile, F. M., Gigante, Antonio, Mastinu, F., Di Benedetto, A., Pata, P., Arcangeli, A., Orsini, P., Acler, P., De Blasi, G., Cicioni, G., Pocciati, S., Marangoni, A., Nogara, A., Lanero, M., Bertero, M. G., Damassino, R., Bergonzini, C., Schumtz, L., Seksich, L., Pipitone, A., Boaretto, M., Manfroi, I., Parmesan, L., Conte, B., Soccol, F., Pagano, A., Papini, E., Rinaldi, R., Petrucci, L., Graziano, F., Chianelli, M., Silvagni, S., Rosco, M., Ansaldi, E., Malvicino, F., Battezzati, M., Maresca, P., Palenzona, C., Boemi, M., Rabini, R. A., Brandoni, G., Lanari, L., Gatti, C., Testa, I., Cherubini, V., Doveri, G., Pecorelli, L., Ciccarelli, A., Gallardini, M. B., Courthoud, R., Sara Bredy, S., Ricciardi, G. P., Vitalone, G., Setti, D., Contrini, P., Corsi, A., Ghigliotti, V., Oddone, G., Ponzani, P., Valbonesi, G., Mazzini, V., Di Berardino, P., Colleluori, P., Montani, V., Trosini, V., Velussi, M., Alfidi, P., Verdecchia, B., Baliva, L., Di Pietro, A., Franchi, G., Luce, R. P., Pianta, A., Ferrari, M., Balzano, S., Beltranello, G., Dal Fabbro, S., Aricò, C. N., Cervo, L., Zanon, R., Rossa, S., Di Pace, M. C., Ciavarella, A., Giangiulio, S., Grimaldi, M., Mustacchio, A., Fattor, B., Monauni, T., Cristini, M., Orion, G., Crazzolara, D., Amor, F., Eisath, J. E., Lintner, S., Garavelli, S., Calari, T., Marini, P., Sandri, O., Scala, M., Stroppa, C., Trentin, A., Carlin, R., Carli, B., Sandonà, M., Zortea, C., Bonet, L., Pradel, L., Reato, S., Buschini, M., Bonfiglioli, D., Mones, D., Beldì, F., Morea, A., Bondesan, L., Perbellini, S., Valentini, U., Agosti, B., Corsini, R., Girelli, A., Zarra, E., Rocca, L., Bergmann, M., Pradi, I., Unterkircher, S., Piok, M., Pichler, M., Trinchera, A., Palamà, G., Palma, P., Carboni, L., Murtas, M. G., Mudadu, T., Turco, M. P., Floris, M., Delogu, A., Farris, L., Songini, M., Piras, G., Seguro, R., Floris, R., Corona, G., Lai, M., Piras, E., Contini, P. P., Cocco, S., Pilosu, R. M., Sannia, M. C., Spanu, F., Busciantella Ricci, N., Cartechini, M. G., Agostinelli, G., Fiorelli, C., Nuzzi, A., Ballauri, C., Lesina, A., Romeo, F., Giudici, G., Maciejewska, E. G., Deroma, A., Paduano, M., Rossi, L., Vagnini, C., Dolci, M., Mori, M., Baccetti, F., Gregori, G., Straface, E., Pozzuoli, G., Barone, M., Stasio, G. B., Tondini, S., Borgoni, F., Grosso, J., Scarsellato, C., Sciulli, A., De Marco, F., Confortin, L., Marin, N., Lamonica, M., Gialdino, S., Borzì, V., Gatta, C., Rapisard, R., Strano, S., Calabrò, M., Puccio, L., Zolli, M., Coracina, A., Starnone, V., Del Buono, A., Terracciano, A. M., Monda, M. V., Castro, F., Guaglianone, A., Maccari, V., Corsi, L., Versari, G., Falivene, M. R., Boletto, N., Corsi, S., Marafetti, L., Vitacolonna, E., Capani, F., Caputo, L., Di Nisio, L., Simonetti, F., Boscolo Bariga, A., Ballarin, G., De Boni, S., Di Benedetto, S., Chiambretti, A. M., Di Vito, L., Pascuzzo, M. D., Urli, P., Rumi, P., Balzarini, B., Galli, P., Castellan, M., Giannetti, A., Russotti, C., De Blasi, A., Perna, A., Campanelli, C., Ranchelli, A., Biccheri, D., Dadi, G., Massa, L., Baldi, G. P., Sciacca, F., Costanzo, E., Spada, M., Paolini, G., Ziller, P., Portolan, F., Pasolini, G., Ghilardi, G., Fiorina, P., Grata, M. L., Capretti, L., Speroni, G., Fugazza, L., Massafra, C., Lovagnini Scher, A., Cimicchi, M. C., Percudani, C., Risolo, T., Saccò, P., Gidoni Guarnieri, G. L., Piccolo, D., Bravin, C., De Noni, E., Scarpel, M., Marcon, M., Giacon, F., Panebianco, G., Tadiotto, F., Da Tos, V., D'Ambrosio, M., Pellizzola, D., Zampini, M. A., Frezzati, E., Mari, E., Raminelli, E., Gaiti, D., Bosi, E. A., Chierici, G., Pilla, S., Copelli, M., Zanichelli, P., Bertelli, L., Caretta, P., Vezzani, V., Bodecchi, S., Longobucco, A., Di Lembo, S., Spotti, E., Carrai, E., Degli Innocenti, A., Manini, L., Persico, R., Rossi, C., Magro, G., Marelli, G., Vilei, V., Andrioli, M., Bellato, L., Fedeli, M., Merlini, A., Pinelli, G., Marin, G., Contin, M. L., Gallo, A., Parlato, P., Pecchielan, W., Jacovacci, J., Placentino, G., Richini, D., Molinari, S., Strazzeri, R., Fabbri, T., Di Bartolo, P., Garrapa, G., D'Incau, F., Lagomanzini, P., Conte, P., Todesco, F., Foglini, P., Pantanetti, P., Bedetta, C., Maricotti, R., Tomasi, F., Monesi, M., Graziani, R., Beretta, F., Penna, L., Guberti, A., Dazzi, D., Forte, E., Gasbarrone, A., Marrocco, T., Moschetta, R., Tuccinardi, F., De Meo, F., Coppola, A., Pirolozzi, P., Placitelli, E., Vallefuoco, R., Catone, B., Ceschia, S., Urban, M., Fabbri, F., Torresani, M., Crovetto, R., Battistini, M., Carosia, P., Viviani, G. L., Durante, A., Pais, F., Lilliu, V., Quieto, C., D'Ugo, E., Squadrone, M., Amenduni, T., Iovannisci, M. M., Della Penna, L., Potente, F., Delle Donne, T., Massa, C., Ulisse, M. A., De Berardinis, F., Guarnieri, I., Pace, S., Splendiani, M., Di Giuseppe, R., Brunato, B., Assaloni, R., Muraro, R., Loro, R., Bucciol, S., Lavacca, C., Rossi, M., Sabbatini, G., Quadri, F., Sambuco, L., Santacroce, C., Paola Caretta, D., Marino, C., Micheletti, A., Petrelli, A., Corda, A., Pisano, L., Guaita, G., Deias, C., Trevisan, G., Coletti, I., Iannarelli, R., De Luca, A., Minnucci, A., Antenucci, D., Di Florio, C., Angelicola, G., Bosco, A., Fresco, R., Di Marco, G., Ugolotti, D., Cadossi, T., Di Caro, P., Mazzocchetti, M., Buzzetti, R., Leto, G., Gnessi, C., Cipolloni, L., Foffi, C., Moretti, C., Venditti, C., Meniconi, R., Bertoli, S., Cosimi, S., Di Cianni, G., Turco, A., Richini, A., Marconi, S., Sannino, C., Lemmi, P., Giuntoli, S., Manfrè, N., Giannini, F., Di Carlo, A., Casadidio, I., Melandri, P., Maolo, G., Polenta, B., Piccinini, N., Vincenti, C., Pastore, N., Mega, P., Magurano, E., Cananiello, A., Francescutto, C. A., Brussa Toi, E., Gaspardo, G., Angeli, L., Ronchese, L., Sciangula, L., Ciucci, A., Contartese, A., Banfi, E., Castelli, E., Tatti, P., Bloise, D., Di Mauro, P., Masselli, L., Lo Presti, A., Scarpitta, A. M., Gambina, F., Venezia, A., Morea, R., Lagonigro, G., Copeta, G., Iannucci, V., Milano, V., Trupo, M., Lochmann, A., Marchetto, P. E., Incelli, G., De Paola, G., Steiger, M. M., Gamper, M. A., Breitenberger, S., Holzner, M., Frischmann, J., Lambiase, C., Di Vece, T., D'Aniello, M., Fezza, M., Giordano, C., Leo, F., Saitta, G., Cucinotta, D., Di Vieste, G., Pintaudi, B., Mancuso, T., Musacchio, N., Giancaterini, A., Pessina, L., Salis, G., Schivalocchi, F., Testori, G., Cerutti, N., Morpugo, P. S., Cavaletto, M. L., Bonino, G., Morreale, F., Mariani, G., Ragonesi, P. D., Bollati, P., Colapinto, P., Falqui, L., Bortolato, L., Cosma, A., Pistolato, P., Centenaro, B., Ceccato, A., Campobasso, G., Zaurino, F., Mazzotta, G., Manti, R., Da Ros, R., Carlucci, S., Narduzzi, L., Bortolotto, D., D'Acunto, L., Stanic, L., Volpi, A., Cospite, A. M., Manicardi, V., Michelini, M., Finardi, L., Borghi, F., Manicardi, E., Lombardi, S., Tommasi, C., Iaccarino, M., Cozza, S., Binotto, M., Marini, F., Mecenero, I., Massignani, S., Stecco, P., Urbani, E., Massariol, W., Parolin, R., Gatti, A., Bonavita, M., Creso, E., Giannettino, R., Gobbo, M., Turco, S., Iovine, C., Riccardi, G., Iazzetta, N., Giannattasio, C., Egione, O., Galdieri, S., Velotti, A., Azzolina, A., Annicelli, G., Sorrentino, T., Gaeta, I., Zenari, L., Bertolini, L., Sorgato, C., Grippaldi, F., Stroppiana, M., Popolizio, R., Carbone, N., Grasso, S., Abate, S., Gaggero, G. C., Strazzabosco, M., Brun, E., Carlesi, G. P., Garrone, S., Cicalò, A. M., Clausi, C., Cau, R., Manconi, A., Carboni, A., Angius, M. F., Pinna, A. A., Caria, S., Filigheddu, G. D., Tonolo, G., Carta, I., Calebich, S., Burlotti, C., Saglietti, G., Schellino, A., Madau, G., Cossu, M., Mulas, F., Zoccheddu, S., Balsanelli, M., Fetonti, M., Rotolo, A., Sambo, P., Secchi, E., Angotzi, M. A., Loddoni, S., Brundu, I., Careddu, F., Becciu, A., Gabriella Piras, G., Novara, F., Cipro, F., Torchio, G., Palumbo, P., Bianchi, A., Colucci, G., La Motta, G., Tiengo, A., Avogaro, A., Bruttomesso, D., Crepaldi, C., Fadini, G., Guarnieri, G., Lavagnini, M. T., Maran, A., Vedovato, M., De Kreutzenberg, V., Fedele, D., Lapolla, A., Sartore, G., Bax, G., Cardone, C., Dalfrà, M. G., Masin, M., Toniato, R., Piarulli, Francesco, Mattina, G., Fulantelli, M. A., Gioia, D., Conti, M., Ridola, G., D'Agati, F., Grossi, G., Zavaroni, I., Dei Cas, A., Franzini, L., Usberti, E., Antonimi, M., Anelli, N., Poli, R., Ridolfi, V., Michela, M., Haddoub, S., Prampolini, G., Muoio, A., Filippi, D., Bucci, F., Tardio, S. M., Calderini, M. C., Magotti, M. G., Quarantelli, C., Vernazza, M. A., Carolfi, A., Saracca, R., Picchio, E., Del Sindaco, P., Spalluto, A., Maggiulli, L., Torreggiani, V., Rastelletti, S., Ugolini, C., Pucci, N., Magi, S., Muratori, S., La Penna, G., Consoli, A., Galeone, F., Magiar, A. V., Gherardini, V., Moretti, L., Bientinesi, M., Landi, L., Bernardi, A., Del Prato, S., Miccoli, R., Bianchi, C., Penno, G., Venditti, F., Anichini, R., De Bellis, A., Bruschi, T., Butelli, L., Gioffredi, M., Gori, R., Picciafuochi, R., Malagoli, R., Bernini, A., Gelisio, R., Zanon, M., Del Bianco, A., Bamiston, A., Signorato, M., Citro, G., Calabrese, M., Ianni, L., Lorenzetti, M., Marsocci, A., Guizzotti, S., Memoli, G., Cabasino, F., Farci, F., Atzori, A., Sanna, A., Ghiani, M., Siotto, I., Sedda, M., Manis, A., Loddo, C., Loddo, I., Seguro, P., Cuomo, A., Orlando, L., Olanda, G. B., Pucci, A., Massenzo, M., Sardu, C., Perrone, G., Corazziere, F., La Puzza, I., Tripodi, P. F., Riggio, S., Giampaolo, A., Mannino, D., Aleandri, A. R., Guidi, M. V., Battisti, B., Faraglia, M. R., Lilli, V., Leotta, S., Visalli, N., Gagliardi, A., Fontana, L., Altomare, M., Carletti, S., Abbruzzese, S., Chiaramonte, F., Giordano, R., Rossini, M., Migneco, G., Cappelloni, D., Urbani, A., Piergiovanni, F., Simonetta, A., Massimiani, F., Bulzomì, R., Giuliano, M., Pennafina, M. G., Di Perna, P., D'Accinni, M. P., Paolucci, D., D'Ubaldi, A., D'Angelo, M. T., Masaro, G., Pietrantoni, M., Fratini, M., La Rosa, R., Poggi, M., Piccirilli, F., Pisano, R., Saponara, C., Conforti, I., Penza, A., Scalpone, R., Lo Pinto, S., Iacovella, L., Caccamo, C., Sposito, S., Teodonio, C., Restuccia, M. G., Mirto, G., Girardello, R., Gennaro, R., De Moliner, L., Bettini, E., Mattuzzi, A., Speese, K., Frisinghelli, F., Locatelli, F., Nicoletti, M., Trojan, N., Centis, R., L Volsi, P., Levis, E., Zanette, G., Comba, G., Ballatore, L., Cattaneo, A., Aglialoro, A., Guido, R., Patrone, M., Zecchini, M., Clementi, L., Galetta, M., Marconi, V., Bordin, P., Perale, L., Vinci, C., Sira Zanon, M., Geretto, L., Toffolo, C., Furlan, M. G., Mazzanti, G., Vinci, M., Sica, V., Armeni, M., Derai, R., Ennas, O., Mamusa, S., Pisano, M. A., Carreras, L., Rauseo, A., Cervone, S., Leggieri, A., Pontonio, M., Sturaro, R., Quattrocchi, F., Molinaro, M., Trasatti, M., Ferretti, B., Labarile, G., Baule, G. M., Gentilini, A., Spanu, M. A., Fancellu, A., Bianco, P., Lione, L., Massazza, G., Bocchio, G., Bosco, E., Monachesi, M., Carta, G., Boschetti, M., Ceresola, E., Venier, E., Calcaterra, F., Cataldi, F., Miola, M., Manfrini, S., Lai, A., Locci, B., Putzu, D., Tanganelli, I., Leonini, M., Egger, K., Marchiotto, W., Vincis, L., Orlandini, V., Pilloni, C., Farci, R., Pelligra, I., Renier, G., Mameli, M., Pala, A., Devigus, E., Fumagalli, I., Lalli, C., Leandri, M., Agliani, M., De Pascalis, L., Malci, F., De Ciocchis, A., Diodati, M. B., Macerola, B., Davì, S., Caccavale, A., Brocato, L., Pognant Gros, M., Borla, S., Lattanzi, E., Piersanti, C., Piersanti, A., Spinelli, I., Tuzzoli, L., Tulini, V., Quaranta, G., Iorio, V., Tirabovi, M., De Terlizi, Candia, Massarelli, M. G., Venturi, S., Travaglini, A., Draghi, P., Pomante, P., Richiardi, L., Clerico, A., Bruno, A., Cavallo Perin, P., Ghigo, E., Porta, M., Scuntero, P., Arcari, R., Bertaina, S., Bo, S., Broglio, F., Bruno, G., Degiovanni, M., Fornengo, P., Grassi, G., Inglese, V., Maccario, M., Maghenzani, G., Marena, S., Martina, V., Passera, P., Ruiu, G., Tagliabue, M., Zanone, M., Monge, M., Boffano, G. M., Macrì, K., Maio, P., Ozzello, A., Pergolizzi, E., Gaia, D., Gennari, P., Micali, G., Rossetto, E., Dalmazzo, C., Oreglia, M., Stefani, T., Dossena, C., Paglia, P., Bosoni, S., Romanelli, T., Inchiostro, S., Dauriz, M., Bossi, C. A., Meregalli, G., Balini, A., Berzi, D., Filippini, B., Crotto, G., Paccagnella, A., Orrasch, M., Sambataro, M., Citro, T., Kiwanuka, E., Bagolin, E., Almoto, B., Macchia, A., Branca, M. T., Filesi, M., Candido, R., Caroli, E., Manca, E., Petrucco, A., Tommasi, E., Jagodnik, G., Baskar, B., Daris, N., Dal Col, P., Pellegrini, M. A., Tonutti, L., Venturini, G., Andreani, M., Turchi, F., Fedrighelli, F., Martinelli, G., Rongioletti, R., Candidi, M., Pais, M., Moro, E., Cervellino, F., Sinisi, R., Zampino, A., Mingardi, R., Lora, L., Reitano, R., Stocchiero, C., Simoncini, M., Mesturino, C. A., Zen, F., Di Pietro, S., Scoponi, C., Tilaro, L., Pelliccioni, S., Slongo, R., Vita, E., Garofalo, A., Vitale, F., Campanella, B., Mastrilli, V., Borrelli, T., D'Avino, A., Perbellini, A., Mirijello, A, Viazzi, F, Fioretto, P, Giorda, C, Ceriello, A, Russo, G, Guida, P, Pontremoli, R, De Cosmo, S, Cimino, A, Fava, D, Meloncelli, I, Nicolucci, A, Pellegrini, F, Rossi, M, Turco, S, Vespasiani, G, Graziano, G, Lucisano, G, Memmo, R, Pellicciotta, E, Paciotti, V, Pupillo, M, Armentano, G, Giovannini, C, Armentano, V, Laudato, M, Acquati, S, Ciardullo, A, Laffi, G, Felace, G, Taboga, C, Tortul, C, Santantonio, G, Suraci, C, Ghisoni, G, Raffa, M, Genovese, S, Lovagnini-Scher, C, Rampini, P, Rocca, A, Ruggeri, P, Tortato, E, Cotti, L, Cristofaro, M, Tagliaferri, M, Comoglio, M, Fornengo, R, Gentile, F, Gigante, A, Mastinu, F, Di Benedetto, A, Pata, P, Arcangeli, A, Orsini, P, Acler, P, De Blasi, G, Cicioni, G, Pocciati, S, Marangoni, A, Nogara, A, Lanero, M, Bertero, M, Damassino, R, Bergonzini, C, Schumtz, L, Seksich, L, Pipitone, A, Boaretto, M, Manfroi, I, Parmesan, L, Conte, B, Soccol, F, Pagano, A, Papini, E, Rinaldi, R, Petrucci, L, Graziano, F, Chianelli, M, Silvagni, S, Rosco, M, Ansaldi, E, Malvicino, F, Battezzati, M, Maresca, P, Palenzona, C, Boemi, M, Rabini, R, Brandoni, G, Lanari, L, Gatti, C, Testa, I, Cherubini, V, Doveri, G, Pecorelli, L, Ciccarelli, A, Gallardini, M, Courthoud, R, Sara Bredy, S, Ricciardi, G, Vitalone, G, Setti, D, Contrini, P, Corsi, A, Ghigliotti, V, Oddone, G, Ponzani, P, Valbonesi, G, Mazzini, V, Di Berardino, P, Colleluori, P, Montani, V, Trosini, V, Velussi, M, Alfidi, P, Verdecchia, B, Baliva, L, Di Pietro, A, Franchi, G, Luce, R, Pianta, A, Ferrari, M, Balzano, S, Beltranello, G, Dal Fabbro, S, Arico, C, Cervo, L, Zanon, R, Rossa, S, Di Pace, M, Ciavarella, A, Giangiulio, S, Grimaldi, M, Mustacchio, A, Fattor, B, Monauni, T, Cristini, M, Orion, G, Crazzolara, D, Amor, F, Eisath, J, Lintner, S, Garavelli, S, Calari, T, Marini, P, Sandri, O, Scala, M, Stroppa, C, Trentin, A, Carlin, R, Carli, B, Sandona, M, Zortea, C, Bonet, L, Pradel, L, Reato, S, Buschini, M, Bonfiglioli, D, Mones, D, Beldi, F, Morea, A, Bondesan, L, Perbellini, S, Valentini, U, Agosti, B, Corsini, R, Girelli, A, Zarra, E, Rocca, L, Bergmann, M, Pradi, I, Unterkircher, S, Piok, M, Pichler, M, Trinchera, A, Palama, G, Palma, P, Carboni, L, Murtas, M, Mudadu, T, Turco, M, Floris, M, Delogu, A, Farris, L, Songini, M, Piras, G, Seguro, R, Floris, R, Corona, G, Lai, M, Piras, E, Contini, P, Cocco, S, Pilosu, R, Sannia, M, Spanu, F, Busciantella Ricci, N, Cartechini, M, Agostinelli, G, Fiorelli, C, Nuzzi, A, Ballauri, C, Lesina, A, Romeo, F, Giudici, G, Maciejewska, E, Deroma, A, Paduano, M, Rossi, L, Vagnini, C, Dolci, M, Mori, M, Baccetti, F, Gregori, G, Straface, E, Pozzuoli, G, Barone, M, Stasio, G, Tondini, S, Borgoni, F, Grosso, J, Scarsellato, C, Sciulli, A, De Marco, F, Confortin, L, Marin, N, Lamonica, M, Gialdino, S, Borzi, V, Gatta, C, Rapisard, R, Strano, S, Calabro, M, Puccio, L, Zolli, M, Coracina, A, Starnone, V, Del Buono, A, Terracciano, A, Monda, M, Castro, F, Guaglianone, A, Maccari, V, Corsi, L, Versari, G, Falivene, M, Boletto, N, Corsi, S, Marafetti, L, Vitacolonna, E, Capani, F, Caputo, L, Di Nisio, L, Simonetti, F, Boscolo Bariga, A, Ballarin, G, De Boni, S, Di Benedetto, S, Chiambretti, A, Di Vito, L, Pascuzzo, M, Urli, P, Rumi, P, Balzarini, B, Galli, P, Castellan, M, Giannetti, A, Russotti, C, De Blasi, A, Perna, A, Campanelli, C, Ranchelli, A, Biccheri, D, Dadi, G, Massa, L, Baldi, G, Sciacca, F, Costanzo, E, Spada, M, Paolini, G, Ziller, P, Portolan, F, Pasolini, G, Ghilardi, G, Fiorina, P, Grata, M, Capretti, L, Speroni, G, Fugazza, L, Massafra, C, Lovagnini Scher, A, Cimicchi, M, Percudani, C, Risolo, T, Sacco, P, Gidoni Guarnieri, G, Piccolo, D, Bravin, C, De Noni, E, Scarpel, M, Marcon, M, Giacon, F, Panebianco, G, Tadiotto, F, Da Tos, V, D'Ambrosio, M, Pellizzola, D, Zampini, M, Frezzati, E, Mari, E, Raminelli, E, Gaiti, D, Bosi, E, Chierici, G, Pilla, S, Copelli, M, Zanichelli, P, Bertelli, L, Caretta, P, Vezzani, V, Bodecchi, S, Longobucco, A, Di Lembo, S, Spotti, E, Carrai, E, Degli Innocenti, A, Manini, L, Persico, R, Rossi, C, Magro, G, Marelli, G, Vilei, V, Andrioli, M, Bellato, L, Fedeli, M, Merlini, A, Pinelli, G, Marin, G, Contin, M, Gallo, A, Parlato, P, Pecchielan, W, Jacovacci, J, Placentino, G, Richini, D, Molinari, S, Strazzeri, R, Fabbri, T, Di Bartolo, P, Garrapa, G, D'Incau, F, Lagomanzini, P, Conte, P, Todesco, F, Foglini, P, Pantanetti, P, Bedetta, C, Maricotti, R, Tomasi, F, Monesi, M, Graziani, R, Beretta, F, Penna, L, Guberti, A, Dazzi, D, Forte, E, Gasbarrone, A, Marrocco, T, Moschetta, R, Tuccinardi, F, De Meo, F, Coppola, A, Pirolozzi, P, Placitelli, E, Vallefuoco, R, Catone, B, Ceschia, S, Urban, M, Fabbri, F, Torresani, M, Crovetto, R, Battistini, M, Carosia, P, Viviani, G, Durante, A, Pais, F, Lilliu, V, Quieto, C, D'Ugo, E, Squadrone, M, Amenduni, T, Iovannisci, M, Della Penna, L, Potente, F, Delle Donne, T, Massa, C, Ulisse, M, De Berardinis, S, Guarnieri, I, Pace, S, Splendiani, M, Di Giuseppe, R, Brunato, B, Assaloni, R, Muraro, R, Loro, R, Bucciol, S, Lavacca, C, Sabbatini, G, Quadri, F, Sambuco, L, Santacroce, C, Paola Caretta, D, Marino, C, Micheletti, A, Petrelli, A, Corda, A, Pisano, L, Guaita, G, Deias, C, Trevisan, G, Coletti, I, Iannarelli, R, De Luca, A, Minnucci, A, Antenucci, D, Di Florio, C, Angelicola, G, Bosco, A, Fresco, R, Di Marco, G, Ugolotti, D, Cadossi, T, Di Caro, P, Mazzocchetti, M, Buzzetti, R, Leto, G, Gnessi, C, Cipolloni, L, Foffi, C, Moretti, C, Venditti, C, Meniconi, R, Bertoli, S, Cosimi, S, Di Cianni, G, Turco, A, Richini, A, Marconi, S, Sannino, C, Lemmi, P, Giuntoli, S, Manfre, N, Giannini, F, Di Carlo, A, Casadidio, I, Melandri, P, Maolo, G, Polenta, B, Piccinini, N, Vincenti, C, Pastore, N, Mega, P, Magurano, E, Cananiello, A, Francescutto, C, Brussa Toi, E, Gaspardo, G, Angeli, L, Ronchese, L, Sciangula, L, Ciucci, A, Contartese, A, Banfi, E, Castelli, E, Tatti, P, Bloise, D, Di Mauro, P, Masselli, L, Lo Presti, A, Scarpitta, A, Gambina, F, Venezia, A, Morea, R, Lagonigro, G, Copeta, G, Iannucci, V, Milano, V, Trupo, M, Lochmann, A, Marchetto, P, Incelli, G, De Paola, G, Steiger, M, Gamper, M, Breitenberger, S, Holzner, M, Frischmann, J, Lambiase, C, Di Vece, T, D'Aniello, M, Fezza, M, Giordano, C, Leo, F, Saitta, G, Cucinotta, D, Di Vieste, G, Pintaudi, B, Mancuso, T, Musacchio, N, Giancaterini, A, Pessina, L, Salis, G, Schivalocchi, F, Testori, G, Cerutti, N, Morpugo, P, Cavaletto, M, Bonino, G, Morreale, F, Mariani, G, Ragonesi, P, Bollati, P, Colapinto, P, Falqui, L, Bortolato, L, Cosma, A, Pistolato, P, Centenaro, B, Ceccato, A, Campobasso, G, Zaurino, F, Mazzotta, G, Manti, R, Da Ros, R, Carlucci, S, Narduzzi, L, Bortolotto, D, D'Acunto, L, Stanic, L, Volpi, A, Cospite, A, Manicardi, V, Michelini, M, Finardi, L, Borghi, F, Manicardi, E, 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- Subjects
Albuminuria ,Diabetic kidney disease ,GFR ,Albuminuria, Diabetic kidney disease, GFR ,Nephrology - Abstract
Background: Albuminuria has been classically considered a marker of kidney damage progression in diabetic patients and it is routinely assessed to monitor kidney function. However, the role of a mild GFR reduction on the development of stage ≥3 CKD has been less explored in type 1 diabetes mellitus (T1DM) patients. Aim of the present study was to evaluate the prognostic role of kidney disease measures, namely albuminuria and reduced GFR, on the development of stage ≥3 CKD in a large cohort of patients affected by T1DM. Methods: A total of 4284 patients affected by T1DM followed-up at 76 diabetes centers participating to the Italian Association of Clinical Diabetologists (Associazione Medici Diabetologi, AMD) initiative constitutes the study population. Urinary albumin excretion (ACR) and estimated GFR (eGFR) were retrieved and analyzed. The incidence of stage ≥3 CKD (eGFR < 60 mL/min/1.73 m2) or eGFR reduction > 30% from baseline was evaluated. Results: The mean estimated GFR was 98 ± 17 mL/min/1.73m2 and the proportion of patients with albuminuria was 15.3% (n = 654) at baseline. About 8% (n = 337) of patients developed one of the two renal endpoints during the 4-year follow-up period. Age, albuminuria (micro or macro) and baseline eGFR < 90 ml/min/m2 were independent risk factors for stage ≥3 CKD and renal function worsening. When compared to patients with eGFR > 90 ml/min/1.73m2 and normoalbuminuria, those with albuminuria at baseline had a 1.69 greater risk of reaching stage 3 CKD, while patients with mild eGFR reduction (i.e. eGFR between 90 and 60 mL/min/1.73 m2) show a 3.81 greater risk that rose to 8.24 for those patients with albuminuria and mild eGFR reduction at baseline. Conclusions: Albuminuria and eGFR reduction represent independent risk factors for incident stage ≥3 CKD in T1DM patients. The simultaneous occurrence of reduced eGFR and albuminuria have a synergistic effect on renal function worsening.
- Published
- 2018
26. Association of kidney disease measures with risk of renal function worsening in patients with type 1 diabetes
- Author
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Mirijello, Antonio, Viazzi, Francesca, Fioretto, Paola, Giorda, Carlo, Ceriello, Antonio, Russo, Giuspina T., Guida, Pietro, Pontremoli, Roberto, De Cosmo, Salvatore, Cimino, Antonino, Fava, Danila, Giorda, Carlo Bruno, Meloncelli, Illidio, Nicolucci, Antonio, Pellegrini, Fabio, Rossi, Maria Chiara, Turco, Salvatore, Vespasiani, Giacomo, Pellegrini, F., Graziano, G., Lucisano, G., Memmo, R., Pellicciotta, E., Paciotti, V., Pupillo, M., Armentano, G., Giovannini, C., Armentano, V., Laudato, M., Turco, S., Acquati, S., Ciardullo, A. V., Laffi, G., Felace, G., Taboga, C., Tortul, C., Santantonio, G., Suraci, C., Ghisoni, G., Raffa, M., Genovese, S., Lovagnini-Scher, C. A., Rampini, P., Rocca, A., Ruggeri, P., Tortato, E., Cotti, L., Cristofaro, M. R., Tagliaferri, M., Comoglio, M., Fornengo, R., De Cosmo, S., Gentile, F. M., Gigante, A., Mastinu, F., Di Benedetto, A., Pata, P., Arcangeli, A., Orsini, P., Acler, P., De Blasi, G., Cicioni, G., Pocciati, S., Marangoni, A., Nogara, A., Lanero, M., Bertero, M. G., Damassino, R., Bergonzini, C., Schumtz, L., Seksich, L., Pipitone, A., Boaretto, M., Manfroi, I., Parmesan, L., Conte, B., Soccol, F., Pagano, A., Papini, E., Rinaldi, R., Petrucci, L., Graziano, F., Chianelli, M., Silvagni, S., Rosco, M., Ansaldi, E., Malvicino, F., Battezzati, M., Maresca, P., Palenzona, C., Boemi, M., Rabini, R. A., Brandoni, G., Lanari, L., Gatti, C., Testa, I., Cherubini, V., Doveri, G., Pecorelli, L., Ciccarelli, A., Gallardini, M. B., Courthoud, R., Sara Bredy, S., Ricciardi, G. P., Vitalone, G., Setti, D., Contrini, P., Corsi, A., Ghigliotti, V., Oddone, G., Ponzani, P., Valbonesi, G., Mazzini, V., Di Berardino, P., Colleluori, P., Montani, V., Trosini, V., Velussi, M., Alfidi, P., Verdecchia, B., Baliva, L., Di Pietro, A., Franchi, G., Luce, R. 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A., Gioia, D., Conti, M., Ridola, G., D'Agati, F., Grossi, G., De Berardinis, F., Zavaroni, I., Dei Cas, A., Franzini, L., Usberti, E., Antonimi, M., Anelli, N., Poli, R., Ridolfi, V., Michela, M., Haddoub, S., Prampolini, G., Muoio, A., Filippi, D., Bucci, F., Tardio, S. M., Calderini, M. C., Magotti, M. G., Quarantelli, C., Vernazza, M. A., Carolfi, A., Saracca, R., Picchio, E., Del Sindaco, P., Spalluto, A., Maggiulli, L., Torreggiani, V., Rastelletti, S., Ugolini, C., Pucci, N., Magi, S., Muratori, S., La Penna, G., Consoli, A., Galeone, F., Magiar, A. V., Gherardini, V., Moretti, L., Bientinesi, M., Landi, L., Bernardi, A., Del Prato, S., Miccoli, R., Bianchi, C., Penno, G., Venditti, F., Anichini, R., De Bellis, A., Bruschi, T., Butelli, L., Gioffredi, M., Gori, R., Picciafuochi, R., Malagoli, R., Bernini, A., Gelisio, R., Zanon, M., Del Bianco, A., Bamiston, A., Signorato, M., Citro, G., Calabrese, M., Ianni, L., Lorenzetti, M., Marsocci, A., Guizzotti, S., Memoli, G., Cabasino, F., Farci, F., Atzori, A., Sanna, A., Ghiani, M., Siotto, I., Sedda, M., Manis, A., Loddo, C., Loddo, I., Seguro, P., Cuomo, A., Orlando, L., Olanda, G. B., Pucci, A., Massenzo, M., Sardu, C., Perrone, G., Corazziere, F., La Puzza, I., Tripodi, P. F., Riggio, S., Giampaolo, A., Mannino, D., Aleandri, A. R., Guidi, M. V., Battisti, B., Faraglia, M. R., Lilli, V., Leotta, S., Visalli, N., Gagliardi, A., Fontana, L., Altomare, M., Carletti, S., Abbruzzese, S., Chiaramonte, F., Giordano, R., Rossini, M., Migneco, G., Cappelloni, D., Urbani, A., Piergiovanni, F., Fava, D., Simonetta, A., Massimiani, F., Bulzomì, R., Giuliano, M., Pennafina, M. G., Di Perna, P., D'Accinni, M. P., Paolucci, D., D'Ubaldi, A., D'Angelo, M. T., Masaro, G., Pietrantoni, M., Fratini, M., La Rosa, R., Poggi, M., Piccirilli, F., Pisano, R., Saponara, C., Conforti, I., Penza, A., Scalpone, R., Lo Pinto, S., Iacovella, L., Caccamo, C., Sposito, S., Teodonio, C., Restuccia, M. G., Mirto, G., Girardello, R., Gennaro, R., De Moliner, L., Bettini, E., Mattuzzi, A., Speese, K., Frisinghelli, F., Locatelli, F., Nicoletti, M., Trojan, N., Centis, R., L Volsi, P., Levis, E., Zanette, G., Comba, G., Ballatore, L., Cattaneo, A., Aglialoro, A., Guido, R., Patrone, M., Zecchini, M., Vespasiani, G., Meloncelli, I., Clementi, L., Galetta, M., Marconi, V., Bordin, P., Perale, L., Vinci, C., Sira Zanon, M., Geretto, L., Toffolo, C., Furlan, M. G., Mazzanti, G., Vinci, M., Sica, V., Armeni, M., Derai, R., Ennas, O., Mamusa, S., Pisano, M. A., Carreras, L., Rauseo, A., Cervone, S., Leggieri, A., Pontonio, M., Sturaro, R., Quattrocchi, F., Molinaro, M., Trasatti, M., Ferretti, B., Labarile, G., Baule, G. M., Gentilini, A., Spanu, M. A., Fancellu, A., Bianco, P., Lione, L., Massazza, G., Bocchio, G., Bosco, E., Monachesi, M., Carta, G., Boschetti, M., Ceresola, E., Venier, E., Calcaterra, F., Cataldi, F., Miola, M., Manfrini, S., Lai, A., Locci, B., Putzu, D., Tanganelli, I., Leonini, M., Egger, K., Marchiotto, W., Vincis, L., Orlandini, V., Pilloni, C., Farci, R., Pelligra, I., Renier, G., Mameli, M., Pala, A., Devigus, E., Fumagalli, I., Lalli, C., Leandri, M., Agliani, M., De Pascalis, L., Malci, F., De Ciocchis, A., Diodati, M. B., Macerola, B., Davì, S., Caccavale, A., Brocato, L., Pognant Gros, M., Borla, S., Lattanzi, E., Piersanti, C., Piersanti, A., Spinelli, I., Tuzzoli, L., Tulini, V., Quaranta, G., Iorio, V., Tirabovi, M., De Terlizi, Candia, Massarelli, M. G., Venturi, S., Travaglini, A., Draghi, P., Pomante, P., Richiardi, L., Clerico, A., Bruno, A., Cavallo Perin, P., Ghigo, E., Porta, M., Scuntero, P., Arcari, R., Bertaina, S., Bo, S., Broglio, F., Bruno, G., Degiovanni, M., Fornengo, P., Grassi, G., Inglese, V., Maccario, M., Maghenzani, G., Marena, S., Martina, V., Passera, P., Ruiu, G., Tagliabue, M., Zanone, M., Monge, M., Boffano, G. M., Macrì, K., Maio, P., Ozzello, A., Pergolizzi, E., Gaia, D., Gennari, P., Micali, G., Rossetto, E., Dalmazzo, C., Oreglia, M., Stefani, T., Dossena, C., Paglia, P., Bosoni, S., Romanelli, T., Inchiostro, S., Dauriz, M., Bossi, C. A., Meregalli, G., Balini, A., Berzi, D., Filippini, B., Crotto, G., Paccagnella, A., Orrasch, M., Sambataro, M., Citro, T., Kiwanuka, E., Bagolin, E., Almoto, B., Macchia, A., Branca, M. T., Filesi, M., Candido, R., Caroli, E., Manca, E., Petrucco, A., Tommasi, E., Jagodnik, G., Baskar, B., Daris, N., Dal Col, P., Pellegrini, M. A., Tonutti, L., Venturini, G., Andreani, M., Turchi, F., Fedrighelli, F., Martinelli, G., Rongioletti, R., Candidi, M., Pais, M., Moro, E., Cervellino, F., Sinisi, R., Zampino, A., Mingardi, R., Lora, L., Reitano, R., Stocchiero, C., Simoncini, M., Mesturino, C. A., Zen, F., Di Pietro, S., Scoponi, C., Tilaro, L., Pelliccioni, S., Slongo, R., Vita, E., Garofalo, A., Vitale, F., Campanella, B., Mastrilli, V., Borrelli, T., D'Avino, A., Perbellini, A., Mirijello, Antonio, Viazzi, Francesca, Fioretto, Paola, Giorda, Carlo, Ceriello, Antonio, Russo, Giuspina T, Guida, Pietro, Pontremoli, Roberto, and De Cosmo, Salvatore, Giordano, Carla
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Adult ,Male ,Nephrology ,medicine.medical_specialty ,endocrine system diseases ,Renal function ,030209 endocrinology & metabolism ,030204 cardiovascular system & hematology ,lcsh:RC870-923 ,Kidney ,urologic and male genital diseases ,GFR ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Internal medicine ,Diabetes mellitus ,medicine ,Humans ,Albuminuria ,Diabetic kidney disease ,Type 1 diabetes ,urogenital system ,business.industry ,Incidence (epidemiology) ,Middle Aged ,lcsh:Diseases of the genitourinary system. Urology ,medicine.disease ,female genital diseases and pregnancy complications ,Albuminuria, Diabetic kidney disease, GFR, Nephrology ,Diabetes Mellitus, Type 1 ,medicine.anatomical_structure ,Italy ,Disease Progression ,Female ,medicine.symptom ,business ,Research Article ,Follow-Up Studies ,Glomerular Filtration Rate ,Kidney disease - Abstract
Background Albuminuria has been classically considered a marker of kidney damage progression in diabetic patients and it is routinely assessed to monitor kidney function. However, the role of a mild GFR reduction on the development of stage ≥3 CKD has been less explored in type 1 diabetes mellitus (T1DM) patients. Aim of the present study was to evaluate the prognostic role of kidney disease measures, namely albuminuria and reduced GFR, on the development of stage ≥3 CKD in a large cohort of patients affected by T1DM. Methods A total of 4284 patients affected by T1DM followed-up at 76 diabetes centers participating to the Italian Association of Clinical Diabetologists (Associazione Medici Diabetologi, AMD) initiative constitutes the study population. Urinary albumin excretion (ACR) and estimated GFR (eGFR) were retrieved and analyzed. The incidence of stage ≥3 CKD (eGFR 30% from baseline was evaluated. Results The mean estimated GFR was 98 ± 17 mL/min/1.73m2 and the proportion of patients with albuminuria was 15.3% (n = 654) at baseline. About 8% (n = 337) of patients developed one of the two renal endpoints during the 4-year follow-up period. Age, albuminuria (micro or macro) and baseline eGFR 90 ml/min/1.73m2 and normoalbuminuria, those with albuminuria at baseline had a 1.69 greater risk of reaching stage 3 CKD, while patients with mild eGFR reduction (i.e. eGFR between 90 and 60 mL/min/1.73 m2) show a 3.81 greater risk that rose to 8.24 for those patients with albuminuria and mild eGFR reduction at baseline. Conclusions Albuminuria and eGFR reduction represent independent risk factors for incident stage ≥3 CKD in T1DM patients. The simultaneous occurrence of reduced eGFR and albuminuria have a synergistic effect on renal function worsening. Electronic supplementary material The online version of this article (10.1186/s12882-018-1136-6) contains supplementary material, which is available to authorized users.
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- 2018
27. Musculoskeletal symptoms at the onset of pediatric tumors and predictive features in the differential diagnosis with juvenile idiopatic arthritis: preliminary analysis of a multicenter, prospective, observational study
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Civino, A, Alighieri, G, Davì, S, Rondelli, R, Martino, S, Filocamo, G, Magnolato, A, Ricci, F, Gallizzi, R, Olivieri, A, Gerloni, V, Lattanzi, B, Soscia, F, De Fanti, A, Magni Manzoni, S, Citiso, S, Quartulli, L, La Torre, F, Rigante, Donato, Maggio, Mc, Marsili, M, Pelagatti, Ma, Conter, V, Fagioli, F, Lepore, L, Pession, A, and Ravelli, A.
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Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA ,Juvenile idiopathic arthritis - Published
- 2017
28. EVALUATION OF THE DISEASE COURSE OF ITALIAN CHILDREN WITH JUVENILE IDIOPATHIC ARTHRITIS TREATED WITH ETANERCEPT: PRELIMINARY RESULTS IN 1019 PATIENTS
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Davì, S., Verazza, S., Consolaro, A., Insalaco, A., Gerloni, V., Cimaz, R., Zulian, F., Lepore, L., Corona, F., Conti, G., Barone, P., Cattalini, M., Cortis, E., Breda, L., Olivieri, A. N., Civino, A., Rigante, D., La Torre, F., D'Angelo, G., Gallizzi, R., Maggio, M. C., Consolini, R., De Fanti, A., Alpigiani, M. G., Martini, A., Ravelli, A., and S. Davì , S. Verazza , A. Consolaro , A. Insalaco , V. Gerloni , R. Cimaz , F. Zulian , L. Lepore , F. Corona , G. Conti , P. Barone , M. Cattalini , E. Cortis , L. Breda , A.N. Olivieri , A. Civino , D. Rigante , F. La Torre , G. D'Angelo , R. Gallizzi , M.C. Maggio , R. Consolini , A. De Fanti , M.G. Alpigiani , A. Martini , A. Ravelli
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Settore MED/38 - Pediatria Generale E Specialistica ,JUVENILE IDIOPATHIC ARTHRITIS, ETANERCEPT, JADAS - Abstract
Methods: This is a multicenter, observational study that includes all children with JIA who were given ETN at Italian pediatric rheumatology centers after January 2000. Patients were classified in 2 groups: patients who were no longer taking ETN at study start (Group 1); patients who were still receiving ETN at study start (Group 2). Patients in Group 1 underwent only retrospective assessments, whereas patients in Group 2 underwent both retrospective and cross-sectional assessments. The primary outcome of the study were reasons for ETN discontinuation in patients in Group 1, and achievement of the states of inactive disease (ID), minimal disease activity (MDA) and parent- and child-acceptable symptom state (PASS, CASS) in patients in Group 2. The above states were assessed through both formal definitions and JADAS cutoffs. The secondary outcome was the evaluation of frequency and characteristics of ETN-related side effects. Results: So far, the data of 1019 patients (629 in Group 1 and 390 in Group 2) have been collected. Among the 629 patients in Group 1, reasons for ETN discontinuation evaluated in 460 patients included disease remission (48.5%), lack of efficacy (26.1%), and side effects (14.8%). The results of assessment of disease state through formal definitions in 371 children of the 390 children in Group 2 who had already undergone the cross-sectional evaluation were the following: ID 39.7%, MDA 63.0%, PASS 82.4%, CASS 75.8%. The percentages of patients who reached the same disease states assessed through JADAS cutoffs were: ID 45.9%, MDA 61.6%, PASS 70.0%, CASS 66.2%. Serious adverse events were seen in 17 patients and included inflammatory bowel disease (8 pts), tuberculosis (1 pt), CMV hepatitis (1 pt), recurrent pneumoniae (1 pt), varicella complicated by bronchopneumonia (1 pt), acute pancreatitis (1pt), bacterial osteomyelitis (1 pt), bladder carcinoma (1pt), thyroid carcinoma (1 pt); 1 patient died of sepsis. Conclusions: A substantial proportion of children currently receiving ETN were in the states of ID or MDA, or were satisfied with treatment outcome. Half of the patients who had been discontinued from ETN before study start had the medication stopped because of disease remission. Serious adverse events were uncommon.
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- 2015
29. Expert consensus on dynamics of laboratory tests for diagnosis of macrophage activation syndrome complicating systemic juvenile idiopathic arthritis
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Ravelli, A, Minoia, F, Davì, S, Horne, A, Bovis, F, Pistorio, A, Aricò, M, Avcin, T, Behrens, Em, De Benedetti, F, Filipovic, A, Grom, Aa, Henter, J-i, Ilowite, Nte, Jordan, Mb, Khubchandani, R, Kitoh, T, Lehmberg, K, Lovell, Dj, Miettunen, P, Nichols, Ke, Ozen, S, Schmid, Jp, Ramanan, Av, Russo, R, Schneider, R, Sterba, G, Uziel, Y, Wallace, C, Wouters, C, Wulffraat, N, Demirkaya, E, Brunner, Hi, Martini, A, Ruperto, N, Cron, Rq, Angioloni, S, Pallotti, C, Pesce, M, Rinaldi, M, Villa, L, Abinun, M, Aggarwal, A, Akikusa, J, Al-mayouf, Sm, Alessio, M, Anton, J, Apaz, Mt, Astigarraga, I, Ayaz, Na, Barone, P, Bica, B, Bolt, I, Breda, L, Chasnyk, V, Cimaz, R, Corona, F, Cuttica, R, D'Angelo, G, Davidsone, Z, De Cunto, C, De Inocencio, J, Eisenstein, E, Enciso, S, Espada, G, Fischbach, M, Frosch, M, Gallizzi, R, Gamir, Ml, Gao, Y-j, Griffin, T, Hashad, S, Hennon, T, Horneff, G, Huasong, Z, Huber, A, Insalaco, A, Ioseliani, M, Jelusic-drazic, M, Jeng, M, Kapovic, A, Kasapcopur, O, Kone-paut, I, De Oliveira, Skf, Lattanzi, B, Lepore, L, Li, C, Lipton, Jm, Magni-manzoni, S, Maritsi, D, Mccurdy, D, Merino, R, Mulaosmanovic, V, Nielsen, S, Pal, P, Prahalad, S, Rigante, Donato, Rumba-rozenfelde, I, Magalhaes, C, Sanner, H, Sawhney, S, Sewairi, Wm, Shakoory, B, Shenoi, S, Clovis, A, Stanevicha, V, Stine, Kc, Susic, G, Sztajnbok, F, Takei, S, Tezer, H, Trauzeddel, R, Tsitsami, E, Unsal, E, Vougiouka, O, Weaver, Lk, Weiss, J, Weitzman, S, Zletni M., On Behalf Of The Pediatric Rheumatology International Trials Organization, The Childhood Arthritis &, Rheumatology Research, Alliance, The Pediatric Rheumatology Collaborative Study Group And The Histiocyte, Society, Rigante D (ORCID:0000-0001-7032-7779), Ravelli, A, Minoia, F, Davì, S, Horne, A, Bovis, F, Pistorio, A, Aricò, M, Avcin, T, Behrens, Em, De Benedetti, F, Filipovic, A, Grom, Aa, Henter, J-i, Ilowite, Nte, Jordan, Mb, Khubchandani, R, Kitoh, T, Lehmberg, K, Lovell, Dj, Miettunen, P, Nichols, Ke, Ozen, S, Schmid, Jp, Ramanan, Av, Russo, R, Schneider, R, Sterba, G, Uziel, Y, Wallace, C, Wouters, C, Wulffraat, N, Demirkaya, E, Brunner, Hi, Martini, A, Ruperto, N, Cron, Rq, Angioloni, S, Pallotti, C, Pesce, M, Rinaldi, M, Villa, L, Abinun, M, Aggarwal, A, Akikusa, J, Al-mayouf, Sm, Alessio, M, Anton, J, Apaz, Mt, Astigarraga, I, Ayaz, Na, Barone, P, Bica, B, Bolt, I, Breda, L, Chasnyk, V, Cimaz, R, Corona, F, Cuttica, R, D'Angelo, G, Davidsone, Z, De Cunto, C, De Inocencio, J, Eisenstein, E, Enciso, S, Espada, G, Fischbach, M, Frosch, M, Gallizzi, R, Gamir, Ml, Gao, Y-j, Griffin, T, Hashad, S, Hennon, T, Horneff, G, Huasong, Z, Huber, A, Insalaco, A, Ioseliani, M, Jelusic-drazic, M, Jeng, M, Kapovic, A, Kasapcopur, O, Kone-paut, I, De Oliveira, Skf, Lattanzi, B, Lepore, L, Li, C, Lipton, Jm, Magni-manzoni, S, Maritsi, D, Mccurdy, D, Merino, R, Mulaosmanovic, V, Nielsen, S, Pal, P, Prahalad, S, Rigante, Donato, Rumba-rozenfelde, I, Magalhaes, C, Sanner, H, Sawhney, S, Sewairi, Wm, Shakoory, B, Shenoi, S, Clovis, A, Stanevicha, V, Stine, Kc, Susic, G, Sztajnbok, F, Takei, S, Tezer, H, Trauzeddel, R, Tsitsami, E, Unsal, E, Vougiouka, O, Weaver, Lk, Weiss, J, Weitzman, S, Zletni M., On Behalf Of The Pediatric Rheumatology International Trials Organization, The Childhood Arthritis &, Rheumatology Research, Alliance, The Pediatric Rheumatology Collaborative Study Group And The Histiocyte, Society, and Rigante D (ORCID:0000-0001-7032-7779)
- Abstract
Objective: To identify which laboratory tests that change over time are most valuable for the timely diagnosis of macrophage activation syndrome (MAS) complicating systemic juvenile idiopathic arthritis (sJIA). Methods: A multistep process, based on a combination of expert consensus and analysis of real patient data, was conducted. A panel of experts was first asked to evaluate 115 profiles of patients with MAS, which included the values of laboratory tests at the pre-MAS visit and at MAS onset, and the change in values between the two time points. The experts were asked to choose the 5 laboratory tests in which change was most important for the diagnosis of MAS and to rank the 5 selected tests in order of importance. The relevance of change in laboratory parameters was further discussed and ranked by the same experts at a consensus conference. Results: Platelet count was the most frequently selected test, followed by ferritin level, aspartate aminotransferase (AST), white cell count, neutrophil count, and fibrinogen and erythrocyte sedimentation rate. Ferritin was most frequently assigned the highest score. At the end of the process, platelet count, ferritin level and AST were the laboratory tests in which the experts found change over time to be most important. Conclusions: We identified the laboratory tests in which change over time is most valuable for the early diagnosis of MAS in sJIA. The dynamics of laboratory values during the course of MAS should be further scrutinised in a prospective study in order to establish the optimal cut-off values for their variation.
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- 2017
30. Development and initial validation of the macrophage activation syndrome/primary hemophagocytic lymphohistiocytosis score, a diagnostic tool that differentiates primary hemophagocytic lymphohistiocytosis from macrophage activation syndrome
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Minoia, F, Bovis, F, Davì, S, Insalaco, A, Lehmberg, K, Shenoi, S, Weitzman, S, Espada, G, Gao, Yj, Anton, J, Kitoh, T, Kasapcopur, O, Sanner, H, Merino, R, Astigarraga, I, Alessio, M, Jeng, M, Chasnyk, V, Nichols, Ke, Huasong, Z, Li, C, Micalizzi, C, Ruperto, N, Martini, A, Cron, Rq, Ravelli, A, Horne, A, Abinun, M, Aggarwal, A, Akikusa, J, Al Mayouf, S, Apaz, Mt, Avcin, T, Ayaz, Na, Barone, P, Bica, B, Bolt, I, Breda, L, Cimaz, R, Corona, F, Cuttica, R, Davidsone, Z, De Cunto, C, De Inocencio, J, Demirkaya, E, Eisenstein, Em, Enciso, S, Fischbach, M, Frosch, M, Gallizzi, R, Gamir, Ml, Griffin, T, Grom, A, Hashad, S, Hennon, T, Henter, Ji, Horneff, G, Huber, A, Ilowite, N, Ioseliani, M, Kapović, Am, Khubchandani, R, Koné Paut, I, de Oliveira, Skf, Lattanzi, B, Lepore, L, Lipton, Jm, Magni Manzoni, S, Maritsi, D, Mccurdy, D, Miettunen, P, Mulaosmanovic, V, Nielsen, S, Ozen, S, Pal, P, Prahalad, S, Rigante, Donato, Rumba Rozenfelde, I, Russo, R, Magalhães, C, Sewairi, Wm, Artur Silva, C, Stanevicha, V, Sterba, G, Stine, Kc, Susic, G, Sztajnbok, F, Takei, S, Trauzeddel, R, Tsitsami, E, Unsal, E, Uziel, Y, Vougiouka, O, Wallace, Ca, Weaver, L, Weiss J, E, Wouters, C, Wulffraat, N, Zletni, M, Aricò, M, Egeler, Rm, Filipovich, Ah, Gadner, H, Imashuku, S, Janka, G, Ladisch, S, Mcclain, Kl, Webb, D., Rigante, Donato (ORCID:0000-0001-7032-7779), Minoia, F, Bovis, F, Davì, S, Insalaco, A, Lehmberg, K, Shenoi, S, Weitzman, S, Espada, G, Gao, Yj, Anton, J, Kitoh, T, Kasapcopur, O, Sanner, H, Merino, R, Astigarraga, I, Alessio, M, Jeng, M, Chasnyk, V, Nichols, Ke, Huasong, Z, Li, C, Micalizzi, C, Ruperto, N, Martini, A, Cron, Rq, Ravelli, A, Horne, A, Abinun, M, Aggarwal, A, Akikusa, J, Al Mayouf, S, Apaz, Mt, Avcin, T, Ayaz, Na, Barone, P, Bica, B, Bolt, I, Breda, L, Cimaz, R, Corona, F, Cuttica, R, Davidsone, Z, De Cunto, C, De Inocencio, J, Demirkaya, E, Eisenstein, Em, Enciso, S, Fischbach, M, Frosch, M, Gallizzi, R, Gamir, Ml, Griffin, T, Grom, A, Hashad, S, Hennon, T, Henter, Ji, Horneff, G, Huber, A, Ilowite, N, Ioseliani, M, Kapović, Am, Khubchandani, R, Koné Paut, I, de Oliveira, Skf, Lattanzi, B, Lepore, L, Lipton, Jm, Magni Manzoni, S, Maritsi, D, Mccurdy, D, Miettunen, P, Mulaosmanovic, V, Nielsen, S, Ozen, S, Pal, P, Prahalad, S, Rigante, Donato, Rumba Rozenfelde, I, Russo, R, Magalhães, C, Sewairi, Wm, Artur Silva, C, Stanevicha, V, Sterba, G, Stine, Kc, Susic, G, Sztajnbok, F, Takei, S, Trauzeddel, R, Tsitsami, E, Unsal, E, Uziel, Y, Vougiouka, O, Wallace, Ca, Weaver, L, Weiss J, E, Wouters, C, Wulffraat, N, Zletni, M, Aricò, M, Egeler, Rm, Filipovich, Ah, Gadner, H, Imashuku, S, Janka, G, Ladisch, S, Mcclain, Kl, Webb, D., and Rigante, Donato (ORCID:0000-0001-7032-7779)
- Abstract
OBJECTIVE: To develop and validate a diagnostic score that assists in discriminating primary hemophagocytic lymphohistiocytosis (pHLH) from macrophage activation syndrome (MAS) related to systemic juvenile idiopathic arthritis. STUDY DESIGN: The clinical, laboratory, and histopathologic features of 362 patients with MAS and 258 patients with pHLH were collected in a multinational collaborative study. Eighty percent of the population was assessed to develop the score and the remaining 20% constituted the validation sample. Variables that entered the best fitted model of logistic regression were assigned a score, based on their statistical weight. The MAS/HLH (MH) score was made up with the individual scores of selected variables. The cutoff in the MH score that discriminated pHLH from MAS best was calculated by means of receiver operating characteristic curve analysis. Score performance was examined in both developmental and validation samples. RESULTS: Six variables composed the MH score: age at onset, neutrophil count, fibrinogen, splenomegaly, platelet count, and hemoglobin. The MH score ranged from 0 to 123, and its median value was 97 (1st-3rd quartile 75-123) and 12 (1st-3rd quartile 11-34) in pHLH and MAS, respectively. The probability of a diagnosis of pHLH ranged from <1% for a score of <11 to >99% for a score of ≥123. A cutoff value of ≥60 revealed the best performance in discriminating pHLH from MAS. CONCLUSION: The MH score is a powerful tool that may aid practitioners to identify patients who are more likely to have pHLH and, thus, could be prioritized for functional and genetic testing.
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- 2017
31. Intra-articular corticosteroids versus intra-articular corticosteroids plus methotrexate in oligoarticular juvenile idiopathic arthritis: a multicentre, prospective, randomised, open-label trial
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Ravelli, A, Davì, S, Bracciolini, G, Pistorio, A, Consolaro, A, van Dijkhuizen, Ehp, Lattanzi, B, Filocamo, G, Verazza, S, Gerloni, V, Gattinara, M, Pontikaki, I, Insalaco, A, De Benedetti, F, Civino, A, Presta, G, Breda, L, Marzetti, V, Pastore, S, Magni Manzoni, S, Maggio, Mc, Garofalo, F, Rigante, Donato, Gattorno, M, Malattia, C, Picco, P, Viola, S, Lanni, S, Ruperto, N, Martini, A., Rigante, Donato (ORCID:0000-0001-7032-7779), Ravelli, A, Davì, S, Bracciolini, G, Pistorio, A, Consolaro, A, van Dijkhuizen, Ehp, Lattanzi, B, Filocamo, G, Verazza, S, Gerloni, V, Gattinara, M, Pontikaki, I, Insalaco, A, De Benedetti, F, Civino, A, Presta, G, Breda, L, Marzetti, V, Pastore, S, Magni Manzoni, S, Maggio, Mc, Garofalo, F, Rigante, Donato, Gattorno, M, Malattia, C, Picco, P, Viola, S, Lanni, S, Ruperto, N, Martini, A., and Rigante, Donato (ORCID:0000-0001-7032-7779)
- Abstract
BACKGROUND: Little evidence-based information is available to guide the treatment of oligoarticular juvenile idiopathic arthritis. We aimed to investigate whether oral methotrexate increases the efficacy of intra-articular corticosteroid therapy. METHODS: We did this prospective, open-label, randomised trial at ten hospitals in Italy. Using a concealed computer-generated list, children younger than 18 years with oligoarticular-onset disease were randomly assigned (1:1) to intra-articular corticosteroids alone or in combination with oral methotrexate (15 mg/m2; maximum 20 mg). Corticosteroids used were triamcinolone hexacetonide (shoulder, elbow, wrist, knee, and tibiotalar joints) or methylprednisolone acetate (ie, subtalar and tarsal joints). We did not mask patients or investigators to treatment assignments. Our primary outcome was the proportion of patients in the intention-to-treat population who had remission of arthritis in all injected joints at 12 months. This trial is registered with European Union Clinical Trials Register, EudraCT number 2008-006741-70. FINDINGS: Between July 7, 2009, and March 31, 2013, we screened 226 participants and randomly assigned 102 to intra-articular corticosteroids alone and 105 to intra-articular corticosteroids plus methotrexate. 33 (32%) patients assigned to intra-articular corticosteroids alone and 39 (37%) assigned to intra-articular corticosteroids and methotrexate therapy had remission of arthritis in all injected joints (p=0·48). Adverse events were recorded for 20 (17%) patients who received methotrexate, which led to permanent treatment discontinuation in two patients (one due to increased liver transaminases and one due to gastrointestinal discomfort). No patient had a serious adverse event. INTERPRETATION: Concomitant administration of methotrexate did not augment the effectiveness of intra-articular corticosteroid therapy. Future studies are needed to define the optimal therapeutic strategies for oligoarticular juve
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- 2017
32. Expert consensus on dynamics of laboratory tests for diagnosis of macrophage activation syndrome complicating systemic juvenile idiopathic arthritis
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Ravelli, A, Minoia, F, Davì, S, Horne, A, Bovis, F, Pistorio, A, Aricò, M, Avcin, T, Behrens, Em, De Benedetti, F, Filipovic, A, Grom, Aa, Henter, J-i, Ilowite, Nte, Jordan, Mb, Khubchandani, R, Kitoh, T, Lehmberg, K, Lovell, Dj, Miettunen, P, Nichols, Ke, Ozen, S, Schmid, Jp, Ramanan, Av, Russo, R, Schneider, R, Sterba, G, Uziel, Y, Wallace, C, Wouters, C, Wulffraat, N, Demirkaya, E, Brunner, Hi, Martini, A, Ruperto, N, Cron, Rq, Angioloni, S, Pallotti, C, Pesce, M, Rinaldi, M, Villa, L, Abinun, M, Aggarwal, A, Akikusa, J, Al-mayouf, Sm, Alessio, M, Anton, J, Apaz, Mt, Astigarraga, I, Ayaz, Na, Barone, P, Bica, B, Bolt, I, Breda, L, Chasnyk, V, Cimaz, R, Corona, F, Cuttica, R, D'Angelo, G, Davidsone, Z, De Cunto, C, De Inocencio, J, Eisenstein, E, Enciso, S, Espada, G, Fischbach, M, Frosch, M, Gallizzi, R, Gamir, Ml, Gao, Y-j, Griffin, T, Hashad, S, Hennon, T, Horneff, G, Huasong, Z, Huber, A, Insalaco, A, Ioseliani, M, Jelusic-drazic, M, Jeng, M, Kapovic, A, Kasapcopur, O, Kone-paut, I, De Oliveira Skf, Lattanzi, B, Lepore, L, Li, C, Lipton, Jm, Magni-manzoni, S, Maritsi, D, Mccurdy, D, Merino, R, Mulaosmanovic, V, Nielsen, S, Pal, P, Prahalad, S, Rigante, Donato, Rumba-rozenfelde, I, Magalhaes, Cs, Sanner, H, Sawhney, S, Sewairi, Wm, Shakoory, B, Shenoi, S, Clovis, As, Stanevicha, V, Stine, Kc, Susic, G, Sztajnbok, F, Takei, S, Tezer, H, Trauzeddel, R, Tsitsami, E, Unsal, E, Vougiouka, O, Weaver, Lk, Weiss, J, Weitzman, S, On Behalf Of The Pediatric Rheumatology International Trials Organization, Zletni M., The Childhood Arthritis & Rheumatology Research Alliance, The Pediatric Rheumatology Collaborative Study Group And The Histiocyte Society, Ravelli, A., Minoia, F., Davi, S., Horne, A., Bovis, F., Pistorio, A., Arico, M., Avcin, T., Behrens, E. M., De Benedetti, F., Filipovic, A., Grom, A. A., Henter, J. -I., Ilowite, N. T., Jordan, M. B., Khubchandani, R., Kitoh, T., Lehmberg, K., Lovell, D. J., Miettunen, P., Nichols, K. E., Ozen, S., Schmid, J. P., Ramanan, A. V., Russo, R., Schneider, R., Sterba, G., Uziel, Y., Wallace, C., Wouters, C., Wulffraat, N., Demirkaya, E., Brunner, H. I., Martini, A., Ruperto, N., Cron, R. Q., Angioloni, S., Pallotti, C., Pesce, M., Rinaldi, M., Villa, L., Abinun, M., Aggarwal, A., Akikusa, J., Al-Mayouf, S. M., Alessio, M., Anton, J., Apaz, M. T., Astigarraga, I., Ayaz, N. A., Barone, P., Bica, B., Bolt, I., Breda, L., Chasnyk, V., Cimaz, R., Corona, F., Cuttica, R., D'Angelo, G., Davidsone, Z., De Cunto, C., De Inocencio, J., Eisenstein, E., Enciso, S., Espada, G., Fischbach, M., Frosch, M., Gallizzi, R., Gamir, M. L., Gao, Y. -J., Griffin, T., Hashad, S., Hennon, T., Horneff, G., Huasong, Z., Huber, A., Insalaco, A., Ioseliani, M., Jelusic-Drazic, M., Jeng, M., Kapovic, A., Kasapcopur, O., Kone-Paut, I., De Oliveira, S. K. F., Lattanzi, B., Lepore, L., Li, C., Lipton, J. M., Magni-Manzoni, S., Maritsi, D., Mccurdy, D., Merino, R., Mulaosmanovic, V., Nielsen, S., Pal, P., Prahalad, S., Rigante, D., Rumba-Rozenfelde, I., Magalhaes, C. S., Sanner, H., Sawhney, S., Sewairi, W. M., Shakoory, B., Shenoi, S., Clovis, A. S., Stanevicha, V., Stine, K. C., Susic, G., Sztajnbok, F., Takei, S., Tezer, H., Trauzeddel, R., Tsitsami, E., Unsal, E., Vougiouka, O., Weaver, L. K., Weiss, J., Weitzman, S., Zletni, M., and Çocuk Sağlığı ve Hastalıkları
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medicine.medical_specialty ,systemic juvenile idiopathic arthritis ,Epidemiology ,Immunology ,Arthritis ,Bioinformatics ,03 medical and health sciences ,0302 clinical medicine ,Rheumatology ,Internal medicine ,medicine ,Journal Article ,Immunology and Allergy ,030212 general & internal medicine ,Juvenile Idiopathic Arthritis ,Prospective cohort study ,030203 arthritis & rheumatology ,medicine.diagnostic_test ,business.industry ,Paediatric Rheumatology ,medicine.disease ,Outcomes research ,Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA ,Macrophage activation syndrome ,Erythrocyte sedimentation rate ,Absolute neutrophil count ,sense organs ,business - Abstract
OBJECTIVE: To identify which laboratory tests that change over time are most valuable for the timely diagnosis of macrophage activation syndrome (MAS) complicating systemic juvenile idiopathic arthritis (sJIA).METHODS: A multistep process, based on a combination of expert consensus and analysis of real patient data, was conducted. A panel of experts was first asked to evaluate 115 profiles of patients with MAS, which included the values of laboratory tests at the pre-MAS visit and at MAS onset, and the change in values between the two time points. The experts were asked to choose the 5 laboratory tests in which change was most important for the diagnosis of MAS and to rank the 5 selected tests in order of importance. The relevance of change in laboratory parameters was further discussed and ranked by the same experts at a consensus conference.RESULTS: Platelet count was the most frequently selected test, followed by ferritin level, aspartate aminotransferase (AST), white cell count, neutrophil count, and fibrinogen and erythrocyte sedimentation rate. Ferritin was most frequently assigned the highest score. At the end of the process, platelet count, ferritin level and AST were the laboratory tests in which the experts found change over time to be most important.CONCLUSIONS: We identified the laboratory tests in which change over time is most valuable for the early diagnosis of MAS in sJIA. The dynamics of laboratory values during the course of MAS should be further scrutinised in a prospective study in order to establish the optimal cut-off values for their variation.
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- 2016
33. Treatment with etanercept in 1019 Italian children with juvenile idiopathic arthriti: preliminary results
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Davì, S, Verazza, S, Consolaro, A, Insalaco, A, Gerloni, V, Cimaz, R, Zulian, F, Lepore, L, Corona, F, Conti, G, Barone, P, Cattalini, M, Cortis, E, Breda, L, Olivieri, An, Civino, A, Rigante, Donato, La Torre, F, D'Angelo, G, Gallizzi, R, Maggio, Mc, Consolini, R, De Fanti, A, Alpigiani, Mg, Martini, A, and Ravelli, A.
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Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA ,Juvenile idiopathic arthritis - Published
- 2015
34. Disease status, reasons for discontinuation and adverse events in 1038 Italian children with juvenile idiopathic arthritis treated with etanercept.
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Verazza, S, Davì, S, Consolaro, A, Bovis, F, Insalaco, A, Magni Manzoni, S, Nicolai, R, Marafon, Dp, De Benedetti, F, Gerloni, V, Pontikaki, I, Rovelli, F, Cimaz, R, Marino, A, Zulian, F, Martini, G, Pastore, S, Sandrin, C, Corona, F, Torcoletti, M, Conti, G, Fede, C, Barone, P, Cattalini, M, Cortis, E, Breda, L, Olivieri, An, Civino, A, Podda, R, Rigante, Donato, La Torre, F, D'Angelo, G, Jorini, M, Gallizzi, R, Maggio, Mc, Consolini, R, De Fanti, A, Muratore, V, Alpigiani, Mg, Ruperto, N, Martini, A, Ravelli, A., Rigante, Donato (ORCID:0000-0001-7032-7779), Verazza, S, Davì, S, Consolaro, A, Bovis, F, Insalaco, A, Magni Manzoni, S, Nicolai, R, Marafon, Dp, De Benedetti, F, Gerloni, V, Pontikaki, I, Rovelli, F, Cimaz, R, Marino, A, Zulian, F, Martini, G, Pastore, S, Sandrin, C, Corona, F, Torcoletti, M, Conti, G, Fede, C, Barone, P, Cattalini, M, Cortis, E, Breda, L, Olivieri, An, Civino, A, Podda, R, Rigante, Donato, La Torre, F, D'Angelo, G, Jorini, M, Gallizzi, R, Maggio, Mc, Consolini, R, De Fanti, A, Muratore, V, Alpigiani, Mg, Ruperto, N, Martini, A, Ravelli, A., and Rigante, Donato (ORCID:0000-0001-7032-7779)
- Abstract
BACKGROUND: Data from routine clinical practice are needed to further define the efficacy and safety of biologic medications in children with juvenile idiopathic arthritis (JIA). The aim of this analysis was to investigate the disease status, reasons for discontinuation and adverse events in Italian JIA patients treated with etanercept (ETN). METHODS: In 2013, all centers of the Italian Pediatric Rheumatology Study Group were asked to make a census of patients given ETN after January 2000. Patients were classified in three groups: group 1 = patients still taking ETN; group 2 = patients discontinued from ETN for any reasons; group 3 = patients lost to follow-up while receiving ETN. All three groups received a retrospective assessment; patients in group 1 also underwent a cross-sectional assessment. RESULTS: 1038 patients were enrolled by 23 centers: 422 (40.7%) were in group 1, 462 (44.5%) in group 2, and 154 (14.8%) in group 3. Median duration of ETN therapy was 2.5 years. At cross-sectional assessment, 41.8% to 48.6% of patients in group 1 met formal criteria for inactive disease, whereas 52.4% of patients in group 2 and 55.8% of patients in group 3 were judged in clinical remission by their caring physician at last visit. A relatively greater proportion of patients with systemic arthritis were discontinued or lost to follow-up. Parent evaluations at cross-sectional visit in group 1 showed that 52.4% of patients had normal physical function, very few had impairment in quality of life, 51.2% had no pain, 76% had no morning stiffness, and 82.7% of parents were satisfied with their child's illness outcome. Clinically significant adverse events were reported for 27.8% of patients and ETN was discontinued for side effects in 9.5%. The most common adverse events were new onset or recurrent uveitis (10.2%), infections (6.6%), injection site reactions (4.4%), and neuropsychiatric (3.1%), gastrointestinal (2.4%), and hematological disorders (2.1%). Ten patients developed an
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- 2016
35. Clinical features, treatment, and outcome of macrophage activation syndrome complicating systemic juvenile idiopathic arthritis: a multinational, multicenter study of 362 patients
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Minoia, F, Davì, S, Horne, A, Demirkaya, E, Bovis, Francesca, Li, C, Lehmberg, K, Weitzman, S, Insalaco, A, Wouters, C, Shenoi, S, Espada, G, Ozen, S, Anton, J, Khubchandani, R, Russo, R, Pal, P, Kasapcopur, O, Miettunen, P, Maritsi, D, Merino, R, Shakoory, B, Alessio, M, Chasnyk, V, Sanner, H, Gao, Yj, Huasong, Z, Kitoh, T, Avcin, T, Fischbach, M, Frosch, M, Grom, A, Huber, A, Jelusic, M, Sawhney, S, Uziel, Y, Ruperto, N, Martini, Alberto, Cron, Rq, Ravelli, Angelo, Minoia, F., Davi, S., Horne, A., Demirkaya, E., Bovis, F., Li, C., Lehmberg, K., Weitzman, S., Insalaco, A., Wouters, C., Shenoi, S., Espada, G., Ozen, S., Anton, J., Khubchandani, R., Russo, R., Pal, P., Kasapcopur, O., Miettunen, P., Maritsi, D., Merino, R., Shakoory, B., Alessio, M., Chasnyk, V., Sanner, H., Gao, Y. -J., Huasong, Z., Kitoh, T., Avcin, T., Fischbach, M., Frosch, M., Grom, A., Huber, A., Jelusic, M., Sawhney, S., Uziel, Y., Ruperto, N., Martini, A., Cron, R. Q., and Ravelli, A.
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musculoskeletal diseases ,Male ,Biological Products ,Fever ,International Cooperation ,Macrophage Activation Syndrome ,Arthritis, Juvenile ,Cohort Studies ,Survival Rate ,Intensive Care Units ,Treatment Outcome ,Adrenal Cortex Hormones ,Child, Preschool ,Splenomegaly ,Cyclosporine ,Prevalence ,Humans ,Female ,Child ,Etoposide ,Hepatomegaly ,Retrospective Studies - Abstract
Objective To describe the clinical, laboratory, and histopathologic features, current treatment, and outcome of patients with macrophage activation syndrome (MAS) complicating systemic juvenile idiopathic arthritis (JIA). Methods In this multinational, multicenter study, pediatric rheumatologists and hemato-oncologists entered patient data collected retrospectively into a web-based database. Results A total of 362 patients, 22% of whom had MAS at the onset of systemic JIA, were included in the study by 95 investigators from 33 countries. The most frequent clinical manifestations were fever (96%), hepatomegaly (70%), and splenomegaly (58%). Central nervous system dysfunction and hemorrhages were recorded in 35% and 20% of the patients, respectively. Platelet count and liver transaminase, ferritin, lactate dehydrogenase, triglyceride, and d-dimer levels were the sole laboratory biomarkers showing a percentage change of >50% between the pre-MAS visit and MAS onset. Evidence of macrophage hemophagocytosis was found in 60% of the patients who underwent bone marrow aspiration. MAS occurred most frequently in the setting of active underlying disease, in the absence of a specific trigger. Nearly all patients were given corticosteroids, and 61% received cyclosporine. Biologic medications and etoposide were given to 15% and 12% of the patients, respectively. Approximately one-third of the patients required admission to the intensive care unit (ICU), and the mortality rate was 8%. Conclusion This study provides information on the clinical spectrum and current management of systemic JIA-associated MAS through the analysis of a very large patient sample. MAS remains a serious condition, as a sizeable proportion of patients required admission to the ICU or died.
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- 2014
36. An international consensus survey of diagnostic criteria for macrophage activation syndrome in systemic juvenile idiopathic arthritis
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Davì, S, Consolaro, Alessandro, Guseinova, D, Pistorio, A, Ruperto, N, Martini, Alberto, Cron, Rq, and Ravelli, Angelo
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- 2011
37. High levels of interferon-gamma (IFNγ) in macrophage activation syndrome (MAS) and CXCL9 levels as a biomarker for IFNγ production in MAS
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Bracaglia, C, primary, Marafon, D Pires, additional, Caiello, I, additional, de Graaf, K, additional, Guilhot, F, additional, Ferlin, W, additional, Davì, S, additional, Schulert, G, additional, Ravelli, A, additional, Grom, A, additional, Nelson, R, additional, de Min, C, additional, and De Benedetti, F, additional
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- 2015
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38. AB1020 Evaluation of the Disease Course of Italian Children with Juvenile Idiopathic Arthritis Treated with Etanercept: Preliminary Results in 1019 Patients
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Davì, S., primary, Verazza, S., additional, Consolaro, A., additional, Insalaco, A., additional, Gerloni, V., additional, Cimaz, R., additional, Zulian, F., additional, Lepore, L., additional, Corona, F., additional, Conti, G., additional, Barone, P., additional, Cattalini, M., additional, Cortis, E., additional, Breda, L., additional, Olivieri, A.N., additional, Civino, A., additional, Rigante, D., additional, La Torre, F., additional, D'Angelo, G., additional, Gallizzi, R., additional, Maggio, M.C., additional, Consolini, R., additional, De Fanti, A., additional, Alpigiani, M.G., additional, Martini, A., additional, and Ravelli, A., additional
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- 2015
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39. SAT0486 Macrophage Activation Syndrome and Familial Hemophagocytic Lymphohistiocytosis: Is Their Clinical Phenotype Really Similar?
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Horne, A., primary, Minoia, F., additional, Davì, S., additional, Bovis, F., additional, Rosina, S., additional, Lehmberg, K., additional, Weitzman, S., additional, Insalaco, A., additional, Wouters, C., additional, Shenoi, S., additional, Espada, G., additional, Ozen, S., additional, Anton, J., additional, Khubchandani, R., additional, Russo, R., additional, Ruperto, N., additional, Martini, A., additional, Cron, R., additional, and Ravelli, A., additional
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- 2015
- Full Text
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40. A controlled trial of intra-articular corticosteroids with or without methotrexate in oligoarticular juvenile idiopathic arthritis
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Ravelli, A, Bracciolini, G, Davì, S, Pistorio, A, Consolaro, A, Verazza, S, Lattanzi, B, Filocamo, G, Dalpra, S, Gattinara, M, Gerloni, V, Insalaco, A, De Benedetti, F, Civino, A, Breda, L, Lepore, L, Maggio, Mc, Garofalo, F, Magni Manzoni, S, Rigante, Donato, Buoncompagni, A, Gattorno, M, Malattia, C, Viola, S, Picco, P, Ruperto, N, Martini, A., Rigante, Donato (ORCID:0000-0001-7032-7779), Ravelli, A, Bracciolini, G, Davì, S, Pistorio, A, Consolaro, A, Verazza, S, Lattanzi, B, Filocamo, G, Dalpra, S, Gattinara, M, Gerloni, V, Insalaco, A, De Benedetti, F, Civino, A, Breda, L, Lepore, L, Maggio, Mc, Garofalo, F, Magni Manzoni, S, Rigante, Donato, Buoncompagni, A, Gattorno, M, Malattia, C, Viola, S, Picco, P, Ruperto, N, Martini, A., and Rigante, Donato (ORCID:0000-0001-7032-7779)
- Abstract
There is paucity of evidence-based information to guide treatment of oligoarticular juvenile idiopathic arthritis (JIA). We aimed to investigate whether combination with methotrexate increases the efficacy of intra-articular corticosteroid (IAC) therapy in patients with JIA. The report describes our preliminary experience in children aged 18 years or younger who were candidates to receive IAC in one to four joints. We randomly allocated a subgroup of patients via a computer-based system to IAC alone or in combination with methotrexate. Our primary outcome in intention to treat analysis was the proportion of patients achieving remission of synovitis in all injected joints at 12 months.
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- 2014
41. Performance of current guidelines for diagnosis of macrophage activation syndrome complicating systemic juvenile idiopathic arthritis
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Davì, S, Minoia, F, Pistorio, A, Horne, A, Consolaro, A, Rosina, S, Bovis, F, Cimaz, R, Gamir, Ml, Ilowite, N, Kone Paut, I, Feitosa De Oliveira, Sk, Mccurdy, D, Silva, Ca, Sztajnbok, F, Tsitsami, E, Unsal, E, Weiss, Je, Wulffraat, N, Abinun, M, Aggarwal, A, Apaz, Mt, Astigarraga, I, Corona, F, Cuttica, R, D'Angelo, G, Eisenstein, Em, Hashad, S, Lepore, L, Mulaosmanovic, V, Nielsen, S, Prahalad, S, Rigante, Donato, Stanevicha, V, Sterba, G, Susic, G, Takei, S, Trauzeddel, R, Zletni, M, Ruperto, N, Martini, A, Cron, Rq, Ravelli, A., Rigante, Donato (ORCID:0000-0001-7032-7779), Davì, S, Minoia, F, Pistorio, A, Horne, A, Consolaro, A, Rosina, S, Bovis, F, Cimaz, R, Gamir, Ml, Ilowite, N, Kone Paut, I, Feitosa De Oliveira, Sk, Mccurdy, D, Silva, Ca, Sztajnbok, F, Tsitsami, E, Unsal, E, Weiss, Je, Wulffraat, N, Abinun, M, Aggarwal, A, Apaz, Mt, Astigarraga, I, Corona, F, Cuttica, R, D'Angelo, G, Eisenstein, Em, Hashad, S, Lepore, L, Mulaosmanovic, V, Nielsen, S, Prahalad, S, Rigante, Donato, Stanevicha, V, Sterba, G, Susic, G, Takei, S, Trauzeddel, R, Zletni, M, Ruperto, N, Martini, A, Cron, Rq, Ravelli, A., and Rigante, Donato (ORCID:0000-0001-7032-7779)
- Abstract
OBJECTIVE: To compare the capacity of the 2004 diagnostic guidelines for hemophagocytic lymphohistiocytosis (HLH-2004) with the capacity of the preliminary diagnostic guidelines for systemic juvenile idiopathic arthritis (JIA)-associated macrophage activation syndrome (MAS) to discriminate MAS complicating systemic JIA from 2 potentially confusable conditions, represented by active systemic JIA without MAS and systemic infection. METHODS: International pediatric rheumatologists and hemato-oncologists were asked to retrospectively collect clinical information from patients with systemic JIA-associated MAS and confusable conditions. The ability of the guidelines to differentiate MAS from the control diseases was evaluated by calculating the sensitivity and specificity of each set of guidelines and the kappa statistics for concordance with the physician's diagnosis. Owing to the fact that not all patients were assessed for hemophagocytosis on bone marrow aspirates and given the lack of data on natural killer cell activity and soluble CD25 levels, the HLH-2004 guidelines were adapted to enable the diagnosis of MAS when 3 of 5 of the remaining items (3/5-adapted) or 4 of 5 of the remaining items (4/5-adapted) were present. RESULTS: The study sample included 362 patients with systemic JIA and MAS, 404 patients with active systemic JIA without MAS, and 345 patients with systemic infection. The best capacity to differentiate MAS from systemic JIA without MAS was found when the preliminary MAS guidelines were applied. The 3/5-adapted HLH-2004 guidelines performed better than the 4/5-adapted guidelines in distinguishing MAS from active systemic JIA without MAS. The 3/5-adapted HLH-2004 guidelines and the preliminary MAS guidelines with the addition of ferritin levels ≥500 ng/ml discriminated best between MAS and systemic infections. CONCLUSION: The preliminary MAS guidelines showed the strongest ability to identify MAS in systemic JIA. The addition of hyperferritinemia enhanc
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- 2014
42. Short-term mortality risk in children and young adults with type 1 diabetes: the population-based Registry of the Province of Turin, Italy
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Bruno, Graziella, Cerutti, Franco, Merletti, Franco, Novelli, Giulia, Panero, Francesco, Zucco, Chiara, CAVALLO PERIN, Paolo, PIEDMONT STUDY GROUP FOR DIABETES EPIDEMIOLOGY, Cianciosi, S, Perrino, A, Chiambretti, A, Appendino, S, Giorda, C, Imperiale, E, Trinelli, V, Gallo, Marengo, C, Comoglio, M, Trovati, Mariella, Cavalot, F, Ozzello, A, Autino, R, Modina, P, Costalaio, L, Lege, G, Bologna, S, D'Avanzo, D, Davì, S, Dore, M, Condò, C, Bendinelli, G, Bogazzi, A, Gamba, S, Blatto, A, Griseri, P, Matteoda, C, Rabbone, I, Sacchetti, Pisu, E, Grassi, G, Martina, V, Quadri, R, Clerico, A, Veglio, M, Grassi, A, Mormile, A, Martelli, S, Megale, E, Patanè, G, Urli, P, Petraroli, G, and Corgiat Mansin, L.
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Adult ,Male ,Ketoacidosis ,Pediatrics ,medicine.medical_specialty ,Registry ,Adolescent ,Endocrinology, Diabetes and Metabolism ,Population ,Medicine (miscellaneous) ,Survey ,Mortality ,Coma ,Hypoglycaemia ,Young Adult ,Cause of Death ,Diabetes mellitus ,medicine ,Humans ,Diabetic Nephropathies ,Registries ,Young adult ,Child ,education ,Diabetic Coma ,Proportional Hazards Models ,Quality of Health Care ,Type 1 diabetes ,education.field_of_study ,Nutrition and Dietetics ,business.industry ,Mortality rate ,Hazard ratio ,Infant, Newborn ,Infant ,medicine.disease ,Diabetes Mellitus, Type 1 ,Standardized mortality ratio ,Italy ,Child, Preschool ,Cohort ,Kidney Failure, Chronic ,Female ,Cardiology and Cardiovascular Medicine ,business - Abstract
Short-term mortality risk in young diabetic people is an indicator of quality of care. We assessed this in the Italian incident population-based registry of Turin. The study base included 1210 incident cases (n = 677 aged 0–14 years and n = 533 aged 15–29 years) with diabetes, onset period 1974–2000 in the Province of Turin, Italy. The relevant timescale for analysis was the time since the onset of diabetes to death, or till 31 December 2003. Standardized mortality ratio (SMR) for all-cause mortality was computed using the Italian population as a standard, by 5 years, age group, sex, and calendar period. Mean attained age of the incident cohort was 29.7 years (range 5.2–49.7 years). During a mean follow-up period of 15.8 years (range 2.0–29.9 years), there were 19 deaths in 15,967. Nine person-years of observation (n = 9.5 expected deaths), giving an all-cause mortality rate of 1.19/1000 person-years (95% CI 0.76–1.87) and an SMR of 1.96 (1.25–3.08). In no cases did death occur at the onset of diabetes or in childhood. Out of 19 deaths, 9 were diabetes related (n = 6 coma and n = 3 end-stage renal disease). In Cox regression analysis, the hazard ratio (HR) was higher in adult-onset than in childhood-onset diabetes (HR = 3.90, 95% CI 1.14–13.39), independently of calendar period and gender. (1) Children and young adults with type 1 diabetes experienced a two-fold higher short-term mortality risk than Italian people of similar age and sex and (2) the risk was higher in adult-onset than in childhood-onset diabetes. The quality of diabetes care should be improved to prevent early deaths.
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- 2009
43. La sindrome da antifosfolipidi
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Davì, S., Dalprà, S., Verazza, S., and Ravelli, Angelo
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- 2009
44. [Bile dynamics in patients with postcholecystectomy syndrome]
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Pustorino S, Calipari G, Federico G, Di Stefano C, Salvia M, PIERLUIGI CONSOLO, Davì S, and Rodi V
- Abstract
Twenty-three cholecystectomized patients, asymptomatic or with recurrent biliary pain, were studied.Six patients were asymptomatic without organic complications of the biliary tree and negative cholestasis laboratory tests; six were symptomatic with gallstones or stenosis of the main biliary tree; eleven patients were symptomatic without organic diseases. All the groups of patients were matched for age and sex. The filling and emptying kinetics of the biliary tree were studied by sequential cholescintigraphy with trimetil-Br-IDA 99mTc and computized gamma-camera. The exam was performed for sixty minutes during fast and for sixty minutes after a standard cholecystokinetic meal.Hepatic clearance time of the compound, filling and emptying of the biliary tree were significantly longer in patients with organic obstruction than in the other groups. The differences between controls and patients with anorganic diseases were otherwise not significative.1) in cholecystectomized patients the recurrent biliary pain is likely present independently of alterations of the biliary wash-out; 2) sequential cholescintigraphy is a very good method, as well as endoscopic procedures, to identify organic obstruction of the main biliary tree. However, it is not sufficiently sensitive to demonstrate functional alterations of the biliary tract.
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- 2006
45. 'Spleen Pseudocysts'
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Vadalà, G., Milintenda, L., Azzaro, P., Evola, G., Sangani, G., Evola, FRANCESCO ROBERTO, and Vadalà, D. DAVÌ S.
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- 2005
46. PReS-FINAL-2141: Clinical features, therapeutic interventions and outcome of 362 patients with macrophage activation syndrome enrolled in a multinational survey
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Minoia, F, primary, Davì, S, additional, Horne, A, additional, Consolaro, A, additional, Rosina, S, additional, Davidsone, Z, additional, De Cunto, C, additional, De Inocencio, J, additional, Eisenstein, E, additional, Espada, G, additional, Fishbach, M, additional, Frosch, M, additional, Gallizzi, R, additional, Gamir, ML, additional, Griffin, T, additional, Grom, A, additional, Hennon, T, additional, Horneff, G, additional, Huasong, Z, additional, Ruperto, N, additional, Martini, A, additional, Cron, RQ, additional, and Ravelli, A, additional
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- 2013
- Full Text
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47. PReS-FINAL-2176: Declines in levels of disease activity and physical disability in children with juvenile idiopathic arthritis seen in standard clinical care over the last 25 years
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Consolaro, A, primary, Lanni, S, additional, Minoia, F, additional, Davì, S, additional, Dalprà, S, additional, Schiappapietra, B, additional, Muratore, V, additional, Martini, A, additional, and Ravelli, A, additional
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- 2013
- Full Text
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48. OP0135 Clinical and therapeutic features of 270 patients with macrophage activation syndrome enrolled in a multinational survey
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Davì, S., primary, Lattanzi, B., additional, Demirkaya, E., additional, Rosina, S., additional, Novelli, A., additional, Ruperto, N., additional, Martini, A., additional, Cron, R.Q., additional, and Ravelli, A., additional
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- 2013
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49. FRI0330 Development of cut-off values for high disease activity in juvenile idiopathic arthritis based on the juvenile arthritis disease activity score (JADAS)
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Consolaro, A., primary, Bracciolini, G., additional, Frisina, A., additional, Ruperto, N., additional, Magni-Manzoni, S., additional, Malattia, C., additional, Pederzoli, S., additional, Solari, N., additional, Davì, S., additional, Martini, A., additional, and Ravelli, A., additional
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- 2013
- Full Text
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50. Agreement between objective and subjective definitions of inactive disease, remission and minimal disease activity in juvenile idiopathic arthritis
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Schiappapietra, B, primary, Consolaro, A, additional, Magni-Manzoni, S, additional, Solari, N, additional, Lanni, S, additional, Davì, S, additional, Pederzoli, S, additional, Bracciolini, G, additional, Martini, A, additional, and Ravelli, A, additional
- Published
- 2011
- Full Text
- View/download PDF
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