Search

Your search keyword '"Davi, Frederic"' showing total 507 results
Start Over Author "Davi, Frederic"
507 results on '"Davi, Frederic"'

2. IκBε deficiency accelerates disease development in chronic lymphocytic leukemia

Author

Bordini, Jessica, Lenzi, Chiara, Frenquelli, Michela, Morabito, Alessia, Pseftogas, Athanasios, Belloni, Daniela, Mansouri, Larry, Tsiolas, George, Perotta, Eleonora, Ranghetti, Pamela, Gandini, Francesca, Genova, Francesca, Hägerstrand, Daniel, Gavriilidis, Georgios, Keisaris, Sofoklis, Pechlivanis, Nikolaos, Davi, Frederic, Kay, Neil E., Langerak, Anton W., Pospisilova, Sarka, Scarfò, Lydia, Makris, Antonios, Psomopoulos, Fotis E., Stamatopoulos, Kostas, Rosenquist, Richard, Campanella, Alessandro, and Ghia, Paolo

Published
2024
Full Text
View/download PDF

5. Impact of the Types and Relative Quantities of IGHV Gene Mutations in Predicting Prognosis of Patients With Chronic Lymphocytic Leukemia

Author

Kaufman, Matthew, Yan, Xiao-Jie, Li, Wentian, Ghia, Emanuela M, Langerak, Anton W, Rassenti, Laura Z, Belessi, Chrysoula, Kay, Neil E, Davi, Frederic, Byrd, John C, Pospisilova, Sarka, Brown, Jennifer R, Catherwood, Mark, Davis, Zadie, Oscier, David, Montillo, Marco, Trentin, Livio, Rosenquist, Richard, Ghia, Paolo, Barrientos, Jacqueline C, Kolitz, Jonathan E, Allen, Steven L, R., Kanti, Stamatopoulos, Kostas, Kipps, Thomas J, Neuberg, Donna, and Chiorazzi, Nicholas

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Lymphoma, Cancer, Hematology, Lymphatic Research, Rare Diseases, CLL, chronic lymphocytic leukemia, immunoglobulin variable domain, prognosis, somatic mutations, Oncology and Carcinogenesis, Clinical sciences, Oncology and carcinogenesis
Abstract

Patients with CLL with mutated IGHV genes (M-CLL) have better outcomes than patients with unmutated IGHVs (U-CLL). Since U-CLL usually express immunoglobulins (IGs) that are more autoreactive and more effectively transduce signals to leukemic B cells, B-cell receptor (BCR) signaling is likely at the heart of the worse outcomes of CLL cases without/few IGHV mutations. A corollary of this conclusion is that M-CLL follow less aggressive clinical courses because somatic IGHV mutations have altered BCR structures and no longer bind stimulatory (auto)antigens and so cannot deliver trophic signals to leukemic B cells. However, the latter assumption has not been confirmed in a large patient cohort. We tried to address the latter by measuring the relative numbers of replacement (R) mutations that lead to non-conservative amino acid changes (Rnc) to the combined numbers of conservative (Rc) and silent (S) amino acid R mutations that likely do not or cannot change amino acids, "(S+Rc) to Rnc IGHV mutation ratio". When comparing time-to-first-treatment (TTFT) of patients with (S+Rc)/Rnc ≤ 1 and >1, TTFTs were similar, even after matching groups for equal numbers of samples and identical numbers of mutations per sample. Thus, BCR structural change might not be the main reason for better outcomes for M-CLL. Since the total number of IGHV mutations associated better with longer TTFT, better clinical courses appear due to the biologic state of a B cell having undergone many stimulatory events leading to IGHV mutations. Analyses of larger patient cohorts will be needed to definitively answer this question.

Published
2022

7. Detecting measurable residual disease beyond 10−4 by an IGHV leader-based NGS approach improves prognostic stratification in CLL

Author

Hengeveld, Paul J., van der Klift, Michèle Y., Kolijn, P. Martijn, Davi, Frédéric, Kavelaars, François G., de Jonge, Evert, Robrecht, Sandra, Assmann, Jorn L. J. C., van der Straten, Lina, Ritgen, Matthias, Westerweel, Peter E., Fischer, Kirsten, Goede, Valentin, Hallek, Michael, Levin, Mark-David, and Langerak, Anton W.

Published
2023
Full Text
View/download PDF

8. EuroClonality-NGS recommendations for evaluation of B cell clonality analysis by next-generation sequencing – a structured approach with the DEPART algorithm

Author

van den Brand, Michiel, Mobs, Markus, Otto, Franziska, Kroeze, Leonie I., Castro, David Gonzalez-de, Stamatopoulos, Kostas, Davi, Frederic, Bravetti, Clotilde, Kolijn, P. Martijn, Vlachonika, Elisavet, Stewart, J Peter, Pott, Christiane, Hummel, Michael, Darzentas, Nikos, Langerak, Anton W., Fend, Falko, and Groenen, Patricia JTA.

Published
2023
Full Text
View/download PDF

10. Validation of the EuroClonality-NGS DNA capture panel as an integrated genomic tool for lymphoproliferative disorders

Author

Stewart, James Peter, Gazdova, Jana, Darzentas, Nikos, Wren, Dörte, Proszek, Paula, Fazio, Grazia, Songia, Simona, Alcoceba, Miguel, Sarasquete, Maria Eugenia, Villarese, Patrick, van der Klift, Michèle Y., Heezen, Kim C., McCafferty, Neil, Pal, Karol, Catherwood, Mark, Kim, Chang Sik, Srivastava, Shambhavi, Kroeze, Leonie I., Hodges, Elizabeth, Stamatopoulos, Kostas, Klapper, Wolfram, Genuardi, Elisa, Ferrero, Simone, van den Brand, Michiel, Cazzaniga, Giovanni, Davi, Frederic, Sutton, Lesley-Ann, Garcia-Sanz, Ramon, Groenen, Patricia J.T.A., Macintyre, Elizabeth A., Brüggemann, Monika, Pott, Christiane, Langerak, Anton W., and Gonzalez, David

Published
2021
Full Text
View/download PDF

11. Higher-order connections between stereotyped subsets: implications for improved patient classification in CLL

Author

Agathangelidis, Andreas, Chatzidimitriou, Anastasia, Gemenetzi, Katerina, Giudicelli, Veronique, Karypidou, Maria, Plevova, Karla, Davis, Zadie, Yan, Xiao-Jie, Jeromin, Sabine, Schneider, Christof, Pedersen, Lone Bredo, Tschumper, Renee C., Sutton, Lesley-Ann, Baliakas, Panagiotis, Scarfò, Lydia, van Gastel, Ellen J., Armand, Marine, Tausch, Eugen, Biderman, Bella, Baer, Constance, Bagnara, Davide, Navarro, Alba, Langlois de Septenville, Anne, Guido, Valentina, Mitterbauer-Hohendanner, Gerlinde, Dimovski, Aleksandar, Brieghel, Christian, Lawless, Sarah, Meggendorfer, Manja, Brazdilova, Kamila, Ritgen, Matthias, Facco, Monica, Tresoldi, Cristina, Visentin, Andrea, Patriarca, Andrea, Catherwood, Mark, Bonello, Lisa, Sudarikov, Andrey, Vanura, Katrina, Roumelioti, Maria, Skuhrova Francova, Hana, Moysiadis, Theodoros, Veronese, Silvio, Giannopoulos, Krzysztof, Mansouri, Larry, Karan-Djurasevic, Teodora, Sandaltzopoulos, Raphael, Bödör, Csaba, Fais, Franco, Kater, Arnon, Panovska, Irina, Rossi, Davide, Alshemmari, Salem, Panagiotidis, Panagiotis, Costeas, Paul, Espinet, Blanca, Antic, Darko, Foroni, Letizia, Montillo, Marco, Trentin, Livio, Stavroyianni, Niki, Gaidano, Gianluca, Francia di Celle, Paola, Niemann, Carsten, Campo, Elias, Anagnostopoulos, Achilles, Pott, Christiane, Fischer, Kirsten, Hallek, Michael, Oscier, David, Stilgenbauer, Stephan, Haferlach, Claudia, Jelinek, Diane, Chiorazzi, Nicholas, Pospisilova, Sarka, Lefranc, Marie-Paule, Kossida, Sofia, Langerak, Anton W., Belessi, Chrysoula, Davi, Frederic, Rosenquist, Richard, Ghia, Paolo, and Stamatopoulos, Kostas

Published
2021
Full Text
View/download PDF

12. Genetic characterization of B-cell prolymphocytic leukemia: a prognostic model involving MYC and TP53

Author

Chapiro, Elise, Pramil, Elodie, Diop, M'boyba, Roos-Weil, Damien, Dillard, Clémentine, Gabillaud, Clémentine, Maloum, Karim, Settegrana, Catherine, Baseggio, Lucile, Lesesve, Jean-François, Yon, Mélanie, Jondreville, Ludovic, Lesty, Claude, Davi, Frédéric, Le Garff-Tavernier, Magali, Droin, Nathalie, Dessen, Philippe, Algrin, Caroline, Leblond, Véronique, Gabarre, Jean, Bouzy, Simon, Eclache, Virginie, Gaillard, Baptiste, Callet-Bauchu, Evelyne, Muller, Marc, Lefebvre, Christine, Nadal, Nathalie, Ittel, Antoine, Struski, Stéphanie, Collonge-Rame, Marie-Agnès, Quilichini, Benoit, Fert-Ferrer, Sandra, Auger, Nathalie, Radford-Weiss, Isabelle, Wagner, Lena, Scheinost, Sebastian, Zenz, Thorsten, Susin, Santos A., Bernard, Olivier A., and Nguyen-Khac, Florence

Published
2019
Full Text
View/download PDF

15. Inflammation is predictive of outcome in Waldenström macroglobulinemia treated by Bruton tyrosine kinase inhibitors: a multicentric real-life study

Author

Debureaux, Pierre-Edouard, primary, Forgeard, Nathalie, additional, Elessa, Dikelele, additional, Harel, Stéphanie, additional, Frenzel, Laurent, additional, Royer, Bruno, additional, Talbot, Alexis, additional, Choquet, Sylvain, additional, Davi, Frederic, additional, Nguyen-Khac, Florence, additional, Cuccuini, Wendy, additional, Cheminant, Morgane, additional, Bravetti, Clotilde, additional, Lazarian, Gregory, additional, Kaltenbach, Sophie, additional, Hermine, Olivier, additional, Roos-Weil, Damien, additional, Espéli, Marion, additional, Balabanian, Karl, additional, and Arnulf, Bertrand, additional

Published
2023
Full Text
View/download PDF

16. P596: DELETION OF THE SHORT ARM OF CHROMOSOME 8 AND TNFRSF10B LOSS ASSOCIATE TO POOR PROGNOSIS AND DRUG RESISTANCE IN CHRONIC LYMPHOCYTIC LEUKEMIA

Author

Jondreville, Ludovic, primary, Dehgane, Lea, additional, Doualle, Cecile, additional, Smagghe, Luce, additional, Grange, Beatrice, additional, Davi, Frederic, additional, Koch Lerner, Leticia, additional, Garnier, Delphine, additional, Bravetti, Clotilde, additional, Tournilhac, Olivier, additional, Roos-Weil, Damien, additional, Boubaya, Marouane, additional, Chapiro, Elise, additional, A Susin, Santos, additional, and Nguyen-Khac, Florence, additional

Published
2023
Full Text
View/download PDF

17. The Mutator Pathway Is a Feature of Immunodeficiency-Related Lymphomas

Author

Duval, Alex, Raphael, Martine, Brennetot, Caroline, Poirel, Helene, Buhard, Olivier, Aubry, Alban, Martin, Antoine, Krimi, Amor, Leblond, Veronique, Gabarre, Jean, Davi, Frederic, Charlotte, Frederic, Berger, Francoise, Gaidano, Gianluca, Capello, Daniela, Canioni, Danielle, Bordessoule, Dominique, Feuillard, Jean, Gaulard, Philippe, Delfau, Marie Helene, Ferlicot, Sophie, Eclache, Virginie, Prevot, Sophie, Guettier, Catherine, Lefevre, Pascale Cornillet, Adotti, Francoise, Hamelin, Richard, and Dausset, Jean

Published
2004

18. ERIC recommendations for TP53mutation analysis in chronic lymphocytic leukemia—2024 update

Author

Malcikova, Jitka, Pavlova, Sarka, Baliakas, Panagiotis, Chatzikonstantinou, Thomas, Tausch, Eugen, Catherwood, Mark, Rossi, Davide, Soussi, Thierry, Tichy, Boris, Kater, Arnon P., Niemann, Carsten U., Davi, Frederic, Gaidano, Gianluca, Stilgenbauer, Stephan, Rosenquist, Richard, Stamatopoulos, Kostas, Ghia, Paolo, and Pospisilova, Sarka

Abstract

In chronic lymphocytic leukemia (CLL), analysis of TP53aberrations (deletion and/or mutation) is a crucial part of treatment decision-making algorithms. Technological and treatment advances have resulted in the need for an update of the last recommendations for TP53analysis in CLL, published by ERIC, the European Research Initiative on CLL, in 2018. Based on the current knowledge of the relevance of low-burden TP53-mutated clones, a specific variant allele frequency (VAF) cut-off for reporting TP53mutations is no longer recommended, but instead, the need for thorough method validation by the reporting laboratory is emphasized. The result of TP53analyses should always be interpreted within the context of available laboratory and clinical information, treatment indication, and therapeutic options. Methodological aspects of introducing next-generation sequencing (NGS) in routine practice are discussed with a focus on reliable detection of low-burden clones. Furthermore, potential interpretation challenges are presented, and a simplified algorithm for the classification of TP53variants in CLL is provided, representing a consensus based on previously published guidelines. Finally, the reporting requirements are highlighted, including a template for clinical reports of TP53aberrations. These recommendations are intended to assist diagnosticians in the correct assessment of TP53mutation status, but also physicians in the appropriate understanding of the lab reports, thus decreasing the risk of misinterpretation and incorrect management of patients in routine practice whilst also leading to improved stratification of patients with CLL in clinical trials.

Published
2024
Full Text
View/download PDF

21. Figure S2B from Chronic Lymphocytic Leukemia with Mutated IGHV4-34 Receptors: Shared and Distinct Immunogenetic Features and Clinical Outcomes

Author

Xochelli, Aliki, primary, Baliakas, Panagiotis, primary, Kavakiotis, Ioannis, primary, Agathangelidis, Andreas, primary, Sutton, Lesley-Ann, primary, Minga, Eva, primary, Ntoufa, Stavroula, primary, Tausch, Eugen, primary, Yan, Xiao-Jie, primary, Shanafelt, Tait, primary, Plevova, Karla, primary, Boudjogra, Myriam, primary, Rossi, Davide, primary, Davis, Zadie, primary, Navarro, Alba, primary, Sandberg, Yorick, primary, Vojdeman, Fie Juhl, primary, Scarfo, Lydia, primary, Stavroyianni, Niki, primary, Sudarikov, Andrey, primary, Veronese, Silvio, primary, Tzenou, Tatiana, primary, Karan-Djurasevic, Teodora, primary, Catherwood, Mark, primary, Kienle, Dirk, primary, Chatzouli, Maria, primary, Facco, Monica, primary, Bahlo, Jasmin, primary, Pott, Christiane, primary, Pedersen, Lone Bredo, primary, Mansouri, Larry, primary, Smedby, Karin E., primary, Chu, Charles C., primary, Giudicelli, Véronique, primary, Lefranc, Marie-Paule, primary, Panagiotidis, Panagiotis, primary, Juliusson, Gunnar, primary, Anagnostopoulos, Achilles, primary, Vlahavas, Ioannis, primary, Antic, Darko, primary, Trentin, Livio, primary, Montillo, Marco, primary, Niemann, Carsten, primary, Döhner, Hartmut, primary, Langerak, Anton W., primary, Pospisilova, Sarka, primary, Hallek, Michael, primary, Campo, Elias, primary, Chiorazzi, Nicholas, primary, Maglaveras, Nikos, primary, Oscier, David, primary, Gaidano, Gianluca, primary, Jelinek, Diane F., primary, Stilgenbauer, Stephan, primary, Chouvarda, Ioanna, primary, Darzentas, Nikos, primary, Belessi, Chrysoula, primary, Davi, Frederic, primary, Hadzidimitriou, Anastasia, primary, Rosenquist, Richard, primary, Ghia, Paolo, primary, and Stamatopoulos, Kostas, primary

Published
2023
Full Text
View/download PDF

22. Table S1 from Chronic Lymphocytic Leukemia with Mutated IGHV4-34 Receptors: Shared and Distinct Immunogenetic Features and Clinical Outcomes

Author

Xochelli, Aliki, primary, Baliakas, Panagiotis, primary, Kavakiotis, Ioannis, primary, Agathangelidis, Andreas, primary, Sutton, Lesley-Ann, primary, Minga, Eva, primary, Ntoufa, Stavroula, primary, Tausch, Eugen, primary, Yan, Xiao-Jie, primary, Shanafelt, Tait, primary, Plevova, Karla, primary, Boudjogra, Myriam, primary, Rossi, Davide, primary, Davis, Zadie, primary, Navarro, Alba, primary, Sandberg, Yorick, primary, Vojdeman, Fie Juhl, primary, Scarfo, Lydia, primary, Stavroyianni, Niki, primary, Sudarikov, Andrey, primary, Veronese, Silvio, primary, Tzenou, Tatiana, primary, Karan-Djurasevic, Teodora, primary, Catherwood, Mark, primary, Kienle, Dirk, primary, Chatzouli, Maria, primary, Facco, Monica, primary, Bahlo, Jasmin, primary, Pott, Christiane, primary, Pedersen, Lone Bredo, primary, Mansouri, Larry, primary, Smedby, Karin E., primary, Chu, Charles C., primary, Giudicelli, Véronique, primary, Lefranc, Marie-Paule, primary, Panagiotidis, Panagiotis, primary, Juliusson, Gunnar, primary, Anagnostopoulos, Achilles, primary, Vlahavas, Ioannis, primary, Antic, Darko, primary, Trentin, Livio, primary, Montillo, Marco, primary, Niemann, Carsten, primary, Döhner, Hartmut, primary, Langerak, Anton W., primary, Pospisilova, Sarka, primary, Hallek, Michael, primary, Campo, Elias, primary, Chiorazzi, Nicholas, primary, Maglaveras, Nikos, primary, Oscier, David, primary, Gaidano, Gianluca, primary, Jelinek, Diane F., primary, Stilgenbauer, Stephan, primary, Chouvarda, Ioanna, primary, Darzentas, Nikos, primary, Belessi, Chrysoula, primary, Davi, Frederic, primary, Hadzidimitriou, Anastasia, primary, Rosenquist, Richard, primary, Ghia, Paolo, primary, and Stamatopoulos, Kostas, primary

Published
2023
Full Text
View/download PDF

24. Whole-exome sequencing in relapsing chronic lymphocytic leukemia: clinical impact of recurrent RPS15 mutations

Author

Ljungström, Viktor, Cortese, Diego, Young, Emma, Pandzic, Tatjana, Mansouri, Larry, Plevova, Karla, Ntoufa, Stavroula, Baliakas, Panagiotis, Clifford, Ruth, Sutton, Lesley-Ann, Blakemore, Stuart J., Stavroyianni, Niki, Agathangelidis, Andreas, Rossi, Davide, Höglund, Martin, Kotaskova, Jana, Juliusson, Gunnar, Belessi, Chrysoula, Chiorazzi, Nicholas, Panagiotidis, Panagiotis, Langerak, Anton W., Smedby, Karin E., Oscier, David, Gaidano, Gianluca, Schuh, Anna, Davi, Frederic, Pott, Christiane, Strefford, Jonathan C., Trentin, Livio, Pospisilova, Sarka, Ghia, Paolo, Stamatopoulos, Kostas, Sjöblom, Tobias, and Rosenquist, Richard

Published
2016
Full Text
View/download PDF

25. Additional file 1 of Reconstructing B cell lineage trees with minimum spanning tree and genotype abundances

Author

Abdollahi, Nika, Jeusset, Lucile, de Septenville, Anne, Davi, Frederic, and Bernardes, Juliana Silva

Abstract

Additional file 1: Fig. S1. ClonalTree configuration performance; Fig. S2. Performance comparison among GCtree, ClonalTree, and GLaMST using GED distances on three categories of trees; Fig. S3. Editing the reconstructed B cell lineage tree by adding unobserved internal nodes; Fig. S4. Editing the reconstructed BCR lineage tree to reduce the depth of the tree while keeping its overall cost; Fig. S5. An example of MRCA calculation; Fig. S6. An example of COAR calculation for a given leaf.

Published
2023
Full Text
View/download PDF

27. Presence of multiple recurrent mutations confers poor trial outcome of relapsed/refractory CLL

Author

Guièze, Romain, Robbe, Pauline, Clifford, Ruth, de Guibert, Sophie, Pereira, Bruno, Timbs, Adele, Dilhuydy, Marie-Sarah, Cabes, Maite, Ysebaert, Loïc, Burns, Adam, Nguyen-Khac, Florence, Davi, Frédéric, Véronèse, Lauren, Combes, Patricia, Le Garff-Tavernier, Magali, Leblond, Véronique, Merle-Béral, Hélène, Alsolami, Reem, Hamblin, Angela, Mason, Joanne, Pettitt, Andrew, Hillmen, Peter, Taylor, Jenny, Knight, SamanthaJ.L., Tournilhac, Olivier, and Schuh, Anna

Published
2015
Full Text
View/download PDF

28. del(8p) and TNFRSF10Bloss are associated with a poor prognosis and resistance to fludarabine in chronic lymphocytic leukemia

Author

Jondreville, Ludovic, Dehgane, Lea, Doualle, Cecile, Smagghe, Luce, Grange, Beatrice, Davi, Frederic, Lerner, Leticia K., Garnier, Delphine, Bravetti, Clotilde, Tournilhac, Olivier, Roos-Weil, Damien, Boubaya, Marouane, Chapiro, Elise, Susin, Santos A., and Nguyen-Khac, Florence

Abstract

Chronic lymphocytic leukemia (CLL) is a heterogeneous disease, the prognosis of which varies according to the cytogenetic group. We characterized a rare chromosomal abnormality (del(8p), deletion of the short arm of chromosome 8) in the context of CLL. By comparing the largest cohort of del(8p) CLL to date (n= 57) with a non-del(8p) cohort (n= 155), del(8p) was significantly associated with a poor prognosis, a shorter time to first treatment, worse overall survival (OS), and a higher risk of Richter transformation. For patients treated with fludarabine-based regimens, the next-treatment-free survival and the OS were shorter in del(8p) cases (including those with mutated IGHV). One copy of the TNFRSF10Bgene (coding a pro-apoptotic receptor activated by TRAIL) was lost in 91% of del(8p) CLL. TNFRSF10Bwas haploinsufficient in del(8p) CLL, and was involved in the modulation of fludarabine-induced cell death - as confirmed by our experiments in primary cells and in CRISPR-edited TNFRSF10Bknock-out CLL cell lines. Lastly, del(8p) abrogated the synergy between fludarabine and TRAIL-induced apoptosis. Our results highlight del(8p)’s value as a prognostic marker and suggest that fit CLL patients (i.e. with mutated IGHV and no TP53disruption) should be screened for del(8p) before the initiation of fludarabine-based treatment.

Published
2023
Full Text
View/download PDF

29. Molecular Evidence for Antigen Drive in the Natural History of Mantle Cell Lymphoma

Author

Xochelli, Aliki, Sutton, Lesley-Ann, Agathangelidis, Andreas, Stalika, Evangelia, Karypidou, Maria, Marantidou, Fotini, Lopez, Alba Navarro, Papadopoulos, Giorgos, Supikova, Jana, Groenen, Patricia, Boudjogra, Myriam, Sundstrom, Christer, Ponzoni, Maurilio, Francova, Hana Skuhrova, Anagnostopoulos, Achilles, Pospisilova, Sarka, Papadaki, Theodora, Tzovaras, Dimitris, Ghia, Paolo, Pott, Christiane, Davi, Frederic, Campo, Elias, Rosenquist, Richard, Hadzidimitriou, Anastasia, Belessi, Chrysoula, and Stamatopoulos, Kostas

Published
2015
Full Text
View/download PDF

30. Evidence of somatic hypermutation in the antigen binding sites of patients with CLL harboring IGHV genes with 100% germline identity

Author

Sofou, Electra, primary, Zaragoza-Infante, Laura, additional, Pechlivanis, Nikolaos, additional, Karakatsoulis, Georgios, additional, Notopoulou, Sofia, additional, Stavroyianni, Niki, additional, Psomopoulos, Fotis, additional, Georgiou, Elisavet, additional, de Septenville, Anne Langlois, additional, Davi, Frederic, additional, Agathangelidis, Andreas, additional, Chatzidimitriou, Anastasia, additional, and Stamatopoulos, Kostas, additional

Published
2022
Full Text
View/download PDF

31. A Comprehensive DNA Methylome Analysis of Stereotyped and Non-Stereotyped CLL Reveals an Epigenetic Signature with Strong Clinical Impact Encompassing IGHV Status, Stereotypes and IGLV3-21R110

Author

Duran-Ferrer, Martí, primary, Mansouri, Larry, additional, Nadeu, Ferran, additional, Clot, Guillem, additional, Bhoi, Sujata, additional, Ann Sutton, Lesley, additional, Baliakas, Panagiotis, additional, Ek, Sara, additional, Kuci Emruli, Venera, additional, Plevova, Karla, additional, Davis, Zadie, additional, Goransson-Kultima, Hanna, additional, Isaksson, Anders, additional, Smedby, Karin E., additional, Gaidano, Gianluca, additional, Langerak, Anton W., additional, Davi, Frederic, additional, Rossi, Davide, additional, Oscier, David, additional, Pospisilova, Sarka, additional, Karypidou, Maria, additional, Agathangelidis, Andreas, additional, Huber, Wolfgang, additional, Lu, Junyan, additional, Zenz, Thorsten, additional, Delgado, Julio, additional, Lopez-Guillermo, Armando, additional, Ghia, Paolo, additional, Campo, Elías, additional, Stamatopoulos, Kostas, additional, Rosenquist, Richard, additional, and Martín-Subero, José I., additional

Published
2022
Full Text
View/download PDF

32. EBV Dictates Lower Tumor Neoepitopes Scores and Intra-Tumoral Repertoire Diversity in NHL from Immuno-Compromized Patients

Author

Baron, Marine, primary, Labreche, Karim, additional, Bouzidi, Amira, additional, Veyri, Marianne, additional, Désiré, Nathalie, additional, Leblond, Véronique, additional, Coulet, Florence, additional, Boelle, Pierre-Yves, additional, Seck Thiam, Fatou, additional, Roos-Weil, Damien, additional, Charlotte, Frédéric, additional, Davi, Frederic, additional, Poullot, Elsa, additional, Rousseau, Alice, additional, Haioun, Corinne, additional, Spano, Jean-Philippe, additional, Autran, Brigitte, additional, Sylvain, Choquet, additional, and Guihot, Amélie, additional

Published
2022
Full Text
View/download PDF

34. Clinical effect of stereotyped B-cell receptor immunoglobulins in chronic lymphocytic leukaemia: a retrospective multicentre study

Author

Baliakas, Panagiotis, Hadzidimitriou, Anastasia, Sutton, Lesley-Ann, Minga, Eva, Agathangelidis, Andreas, Nichelatti, Michele, Tsanousa, Athina, Scarfò, Lydia, Davis, Zadie, Yan, Xiao-Jie, Shanafelt, Tait, Plevova, Karla, Sandberg, Yorick, Vojdeman, Fie Juhl, Boudjogra, Myriam, Tzenou, Tatiana, Chatzouli, Maria, Chu, Charles C, Veronese, Silvio, Gardiner, Anne, Mansouri, Larry, Smedby, Karin E, Pedersen, Lone Bredo, van Lom, Kirsten, Giudicelli, Véronique, Francova, Hana Skuhrova, Nguyen-Khac, Florence, Panagiotidis, Panagiotis, Juliusson, Gunnar, Angelis, Lefteris, Anagnostopoulos, Achilles, Lefranc, Marie-Paule, Facco, Monica, Trentin, Livio, Catherwood, Mark, Montillo, Marco, Geisler, Christian H, Langerak, Anton W, Pospisilova, Sarka, Chiorazzi, Nicholas, Oscier, David, Jelinek, Diane F, Darzentas, Nikos, Belessi, Chrysoula, Davi, Frederic, Rosenquist, Richard, Ghia, Paolo, and Stamatopoulos, Kostas

Published
2014
Full Text
View/download PDF

37. Impact of the Types and Relative Quantities of IGHV Gene Mutations in Predicting Prognosis of Patients With Chronic Lymphocytic Leukemia

Author

Kaufman, Matthew, primary, Yan, Xiao-Jie, additional, Li, Wentian, additional, Ghia, Emanuela M., additional, Langerak, Anton W., additional, Rassenti, Laura Z., additional, Belessi, Chrysoula, additional, Kay, Neil E., additional, Davi, Frederic, additional, Byrd, John C., additional, Pospisilova, Sarka, additional, Brown, Jennifer R., additional, Catherwood, Mark, additional, Davis, Zadie, additional, Oscier, David, additional, Montillo, Marco, additional, Trentin, Livio, additional, Rosenquist, Richard, additional, Ghia, Paolo, additional, Barrientos, Jacqueline C., additional, Kolitz, Jonathan E., additional, Allen, Steven L., additional, Rai, Kanti R., additional, Stamatopoulos, Kostas, additional, Kipps, Thomas J., additional, Neuberg, Donna, additional, and Chiorazzi, Nicholas, additional

Published
2022
Full Text
View/download PDF

38. Comparative analysis of targeted next-generation sequencing panels for the detection of gene mutations in chronic lymphocytic leukemia: an ERIC multi-center study

Author

Sutton, Lesley-Ann, Ljungström, Viktor, Enjuanes, Anna, Cortese, Diego, Skaftason, Aron, Tausch, Eugen, Kozubik, Katerina Stano, Nadeu, Ferran, Armand, Marine, Malcikova, Jikta, Djureinovic, Tatjana, Forster, Jade, Davis, Zadie, Oscier, David, Rossi, Davide, Ghia, Paolo, Strefford, Jonathan C., Pospisilova, Sarka, Stilgenbauer, Stephan, Davi, Frederic, Campo, Elias, Stamatopoulos, Kostas, Rosenquist, Richard, Karolinska Institutet [Stockholm], Uppsala University, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona (UB), University of Ulm (UUlm), Central European Institute of Technology [Brno] (CEITEC MU), Brno University of Technology [Brno] (BUT), Service d'Hématologie clinique [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Sorbonne Université - Faculté de Médecine (SU FM), Sorbonne Université (SU), University of Southampton, Oncology Institute of Southern Switzerland (IOSI), Universita Vita Salute San Raffaele = Vita-Salute San Raffaele University [Milan, Italie] (UniSR), IRCCS Ospedale San Raffaele [Milan, Italy], Karolinska University Hospital [Stockholm], Sutton, Lesley-Ann, Ljungström, Viktor, Enjuanes, Anna, Cortese, Diego, Skaftason, Aron, Tausch, Eugen, Stano Kozubik, Katerina, Nadeu, Ferran, Armand, Marine, Malcikova, Jikta, Pandzic, Tatjana, Forster, Jade, Davis, Zadie, Oscier, David, Rossi, Davide, Ghia, Paolo, Strefford, Jonathan C, Pospisilova, Sarka, Stilgenbauer, Stephan, Davi, Frederic, Campo, Elia, Stamatopoulos, Kosta, and Rosenquist, Richard

Subjects
Cytogenetics and Molecular Genetics, [SDV]Life Sciences [q-bio], Mutation, Next-generation sequencing, High-Throughput Nucleotide Sequencing, Humans, Chronic Lymphocytic Leukemia, Hematology, Hematologi, Genomics, Precision Medicine, Leukemia, Lymphocytic, Chronic, B-Cell, Article
Abstract

International audience; Next-generation sequencing (NGS) has transitioned from research to clinical routine, yet the comparability of different technologies for mutation profiling remains an open question. We performed a European multicenter (n=6) evaluation of three amplicon-based NGS assays targeting 11 genes recurrently mutated in chronic lymphocytic leukemia. Each assay was assessed by two centers using 48 pre-characterized chronic lymphocytic leukemia samples; libraries were sequenced on the Illumina MiSeq instrument and bioinformatics analyses were centralized. Across all centers the median percentage of target reads ≥100x ranged from 94.2- 99.8%. In order to rule out assay-specific technical variability, we first assessed variant calling at the individual assay level i.e., pairwise analysis of variants detected amongst partner centers. After filtering for variants present in the paired normal sample and removal of PCR/sequencing artefacts, the panels achieved 96.2% (Multiplicom), 97.7% (TruSeq) and 90% (HaloPlex) concordance at a variant allele frequency (VAF) >0.5%. Reproducibility was assessed by looking at the inter-laboratory variation in detecting mutations and 107 of 115 (93% concordance) mutations were detected by all six centers, while the remaining eight variants (7%) were undetected by a single center. Notably, 6 of 8 of these variants concerned minor subclonal mutations (VAF 5%, after rigorous validation, the use of unique molecular identifiers may be necessary to reach a higher sensitivity and ensure consistent and accurate detection of low-frequency variants.

Published
2020

39. A Mendelian predisposition to B-cell lymphoma caused by IL-10R deficiency

Author

Neven, Bénédicte, Mamessier, Emilie, Bruneau, Julie, Kaltenbach, Sophie, Kotlarz, Daniel, Suarez, Felipe, Masliah-Planchon, Julien, Billot, Katy, Canioni, Danielle, Frange, Pierre, Radford-Weiss, Isabelle, Asnafi, Vahid, Murugan, Dhaarini, Bole, Christine, Nitschke, Patrick, Goulet, Olivier, Casanova, Jean-Laurent, Blanche, Stéphane, Picard, Capucine, Hermine, Olivier, Rieux-Laucat, Frederic, Brousse, Nicole, Davi, Frederic, Baud, Véronique, Klein, Christoph, Nadel, Bertrand, Ruemmele, Frank, and Fischer, Alain

Published
2013
Full Text
View/download PDF

40. Inflammatory Waldenström's macroglobulinaemia: A French monocentric retrospective study of 67 patients

Author

Elessa, Dikelele, primary, Debureaux, Pierre‐Edouard, additional, Villesuzanne, Camille, additional, Davi, Frederic, additional, Bravetti, Clotilde, additional, Harel, Stephanie, additional, Talbot, Alexis, additional, Oksenhendler, Eric, additional, Malphettes, Marion, additional, Thieblemont, Catherine, additional, Moatti, Hannah, additional, Maarek, Odile, additional, Arnulf, Bertrand, additional, and Royer, Bruno, additional

Published
2022
Full Text
View/download PDF

42. Identification of Prognostic Factors in Post-Transplant Lymphoproliferative Disorders

Author

Choquet, Sylvain, Bruneel, Marie-France Mamzer, Hermine, Olivier, Porcher, Raphaël, Quoc, Stephanie Nguyen, Davi, Frédéric, Charlotte, Frédéric, Dorent, Richard, Barrou, Benoit, Vernant, Jean-Paul, Raphael, Martine, Levy, Vincent, Leblond, Véronique, Schlag, P. M., editor, Senn, H.-J., editor, Diehl, V., editor, Parkin, D. M., editor, Rajewsky, M. F., editor, Rubens, R., editor, Wannenmacher, M., editor, Rentchnik, P., editor, Oertel, Stephan H., editor, and Riess, Hanno, editor

Published
2002
Full Text
View/download PDF

44. Immunoglobulin Gene Mutational Status Assessment by Next Generation Sequencing in Chronic Lymphocytic Leukemia

Author

Langlois de Septenville, Anne, Boudjoghra, Myriam, Bravetti, Clotilde, Armand, Marine, Salson, Mikaël, Giraud, Mathieu, Davi, Frederic, CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Bioinformatics and Sequence Analysis (BONSAI), Université de Lille, Sciences et Technologies-Inria Lille - Nord Europe, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 (CRIStAL), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 (CRIStAL), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Anton W. Langerak, and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)

Subjects
Somatic hypermutation analysis, Genes, Immunoglobulin, Mutational status, High-Throughput Nucleotide Sequencing, Immunoglobulins, Receptors, Antigen, B-Cell, [SDV.CAN]Life Sciences [q-bio]/Cancer, [SDV.MHEP.HEM]Life Sciences [q-bio]/Human health and pathology/Hematology, Immunoglobulin genes, Leukemia, Lymphocytic, Chronic, B-Cell, [SDV.IMM.IA]Life Sciences [q-bio]/Immunology/Adaptive immunology, hemic and lymphatic diseases, Next generation sequencing, Humans, Chronic lymphocytic leukemia, [INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM], Research Article
Abstract

B cell receptor (BcR) immunoglobulins (IG) display a tremendous diversity due to complex DNA rearrangements, the V(D)J recombination, further enhanced by the somatic hypermutation process. In chronic lymphocytic leukemia (CLL), the mutational load of the clonal BcR IG expressed by the leukemic cells constitutes an important prognostic and predictive biomarker. Here, we provide a reliable methodology capable of determining the mutational status of IG genes in CLL using high-throughput sequencing, starting from leukemic cell DNA or RNA.

Published
2022

45. Stereotyped B-cell receptors in one-third of chronic lymphocytic leukemia: a molecular classification with implications for targeted therapies

Author

Agathangelidis, Andreas, Darzentas, Nikos, Hadzidimitriou, Anastasia, Brochet, Xavier, Murray, Fiona, Yan, Xiao-Jie, Davis, Zadie, van Gastel-Mol, Ellen J., Tresoldi, Cristina, Chu, Charles C., Cahill, Nicola, Giudicelli, Veronique, Tichy, Boris, Pedersen, Lone Bredo, Foroni, Letizia, Bonello, Lisa, Janus, Agnieszka, Smedby, Karin, Anagnostopoulos, Achilles, Merle-Beral, Helene, Laoutaris, Nikolaos, Juliusson, Gunnar, di Celle, Paola Francia, Pospisilova, Sarka, Jurlander, Jesper, Geisler, Christian, Tsaftaris, Athanasios, Lefranc, Marie-Paule, Langerak, Anton W., Oscier, David Graham, Chiorazzi, Nicholas, Belessi, Chrysoula, Davi, Frederic, Rosenquist, Richard, Ghia, Paolo, and Stamatopoulos, Kostas

Published
2012
Full Text
View/download PDF

46. MZ lymphoproliferations: shared and unique characteristics

Author

Xochelli, Aliki, Bikos, Vasilis, Polychronidou, Eleftheria, Galigalidou, Chrysi, Agathangelidis, Andreas, Charlotte, Frédéric, Moschonas, Panagiotis, Davis, Zadie, Colombo, Monica, Roumelioti, Maria, Sutton, Lesley-Ann, Groenen, Patricia, van den Brand, Michiel, Boudjoghra, Myriam, Algara, Patricia, Traverse-Glehen, Alexandra, Ferrer, Ana, Stalika, Evangelia, Karypidou, Maria, Kanellis, George, Kalpadakis, Christina, Mollejo, Manuella, Pangalis, Gerasimos, Vlamos, Panayiotis, Amini, Rose-Marie, Pospisilova, Sarka, Gonzalez, David, Ponzoni, Maurilio, Anagnostopoulos, Achilles, Giudicelli, Véronique, Lefranc, Marie-Paule, Espinet, Blanca, Panagiotidis, Panagiotis, Piris, Miguel Angel, Du, Ming-Qing, Rosenquist, Richard, Papadaki, Theodora, Belessi, Chrysoula, Ferrarini, Manlio, Oscier, David, Tzovaras, Dimitrios, Ghia, Paolo, Davi, Frederic, Hadzidimitriou, Anastasia, Stamatopoulos, Kostas, Apollo - University of Cambridge Repository, Institute of Applied Biosciences, CERTH, Thessaloniki, Greece., Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden, Central European Institute of Technology [Brno] (CEITEC MU), Brno University of Technology [Brno] (BUT), Information Technologies Institute, CERTH, Thessaloniki, Greece., Department of Informatics, Ionian University, Corfu, Greece, Division of Experimental Oncology and Department of Onco-Hematology, IRCCS San Raffaele Scientific Institute and Università Vita-Salute San Raffaele, Milan, Italy., Service d'anatomie et cytologie pathologiques [CHU Saint-Antoine], Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Service de pathologie [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Information Technologies Institute, CERTH, Thessaloniki, Greece, Department of Haematology, Royal Bournemouth Hospital, Bournemouth, UK., Molecular Pathology, Ospedale Policlinico SanMartino, Genoa, Italy., First Department of Propaedeutic Medicine, University of Athens, Athens, Greece, Uppsala Universitet [Uppsala], Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden, Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands., Université Pierre et Marie Curie - Paris 6 (UPMC), Service d'Hématologie Biologique [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Hospital Virgen de la Salud, Toledo, Spain, Department of Pathology and Hematology, Hospices Civils de Lyon (HCL), Laboratori de Citologia Hematològica i Citogenètica Molecular, Servei de Patologia, Hospital del Mar, Barcelona, Spain, Centre for Research and Technology Hellas (CERTH), Hematology Department and HCT Unit, G. Papanicolaou Hospital, Thessaloniki, Greece, Hematopathology Department, Evangelismos Hospital, Athens, Greece., Department of Haematology, University of Crete, Heraklion, Greece., Department of Haematology, Athens Medical Center, Athens, Greece, Department of Informatics [Ionian University], Ionian University [Corfu], Department of Informatics, Ionian University, Corfu, Greece., Department of Genetics and Pathology, Uppsala University Hospital, CEITEC-Central European Institute of Technology, MasarykBrno, Czech Republic., Pathology Unit, Unit of Lymphoid Malignancies, San Raffaele H Scientific Institute, Pathology Unit, San Raffaele Scientific Institute, Milan, Italy, Laboratoire d'ImmunoGénétique Moléculaire (LIGM), Institut de génétique humaine (IGH), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Laboratoris de Citologia Hematológica/Citogenética Molecular. Servei de Patologia, GRETNHE, IMIM-Hospital del Mar, Laboratori de Citologia Hematològica i Citogenètica Molecular, Servei de Patologia, Hospital del Mar, Barcelona, Spain., Pathology Department, IIS 'Fundacion Jimenez Diaz', Madrid, Spain, Pathology, University of Cambridge [UK] (CAM), Division of Cellular and Molecular Pathology, Department of Pathology, University of Cambridge, Cambridge, UK, Hematology Department, Nikea General Hospital, Piraeus, Greece, Direzione Scientifica, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Azienda Ospedaliera Universitaria (AOU) San Martino-IST, Genoa, Italy., Informatics & Telematics Institute (ITI), CERTH, Università Vita e Salute, San Raffaele, Milano, Italy, Division of Experimental Oncology and Department of Onco-Hematology, IRCCS San Raffaele Scientific Institute and Università Vita-Salute San Raffaele, Milan, Italy, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institute of Applied Biosciences, Centre for Research and Technology-Hellas, Thessaloniki, Greece, Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Sweden, Xochelli, Aliki, Bikos, Vasili, Polychronidou, Eleftheria, Galigalidou, Chrysi, Agathangelidis, Andrea, Charlotte, Frédéric, Moschonas, Panagioti, Davis, Zadie, Colombo, Monica, Roumelioti, Maria, Sutton, Lesley-Ann, Groenen, Patricia, van den Brand, Michiel, Boudjoghra, Myriam, Algara, Patricia, Traverse-Glehen, Alexandra, Ferrer, Ana, Stalika, Evangelia, Karypidou, Maria, Kanellis, George, Kalpadakis, Christina, Mollejo, Manuella, Pangalis, Gerasimo, Vlamos, Panayioti, Amini, Rose-Marie, Pospisilova, Sarka, Gonzalez, David, Ponzoni, Maurilio, Anagnostopoulos, Achille, Giudicelli, Véronique, Lefranc, Marie-Paule, Espinet, Blanca, Panagiotidis, Panagioti, Piris, Miguel Angel, Du, Ming-Qing, Rosenquist, Richard, Papadaki, Theodora, Belessi, Chrysoula, Ferrarini, Manlio, Oscier, David, Tzovaras, Dimitrio, Ghia, Paolo, Davi, Frederic, Hadzidimitriou, Anastasia, and Stamatopoulos, Kostas

Subjects
[SDV.GEN]Life Sciences [q-bio]/Genetics, Genes, Immunoglobulin, Genes, Immunoglobulin Heavy Chain, Cancer development and immune defence Radboud Institute for Molecular Life Sciences [Radboudumc 2], [SDV]Life Sciences [q-bio], Immunoglobulin Variable Region, Receptors, Antigen, B-Cell, Lymphoma, B-Cell, Marginal Zone, Rare cancers Radboud Institute for Molecular Life Sciences [Radboudumc 9], Complementarity Determining Regions, marginal zone lymphoma, immunoglobulin gene, antigen, ontogeny, Marginal zone lymphoma, Mutation, Tumor Microenvironment, Humans, Gene Rearrangement, B-Lymphocyte
Abstract

Contains fulltext : 203155.pdf (Publisher’s version ) (Closed access) The B cell receptor immunoglobulin (Ig) gene repertoires of marginal zone (MZ) lymphoproliferations were analyzed in order to obtain insight into their ontogenetic relationships. Our cohort included cases with MZ lymphomas (n = 488), i.e. splenic (SMZL), nodal (NMZL) and extranodal (ENMZL), as well as provisional entities (n = 76), according to the WHO classification. The most striking Ig gene repertoire skewing was observed in SMZL. However, restrictions were also identified in all other MZ lymphomas studied, particularly ENMZL, with significantly different Ig gene distributions depending on the primary site of involvement. Cross-entity comparisons of the MZ Ig sequence dataset with a large dataset of Ig sequences (MZ-related or not; n = 65 837) revealed four major clusters of cases sharing homologous ('public') heavy variable complementarity-determining region 3. These clusters included rearrangements from SMZL, ENMZL (gastric, salivary gland, ocular adnexa), chronic lymphocytic leukemia, but also rheumatoid factors and non-malignant splenic MZ cells. In conclusion, different MZ lymphomas display biased immunogenetic signatures indicating distinct antigen exposure histories. The existence of rare public stereotypes raises the intriguing possibility that common, pathogen-triggered, immune-mediated mechanisms may result in diverse B lymphoproliferations due to targeting versatile progenitor B cells and/or operating in particular microenvironments. Copyright (c) 2018 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

Published
2019

49. Autologous stem cell transplantation as a first-line treatment strategy for chronic lymphocytic leukemia: a multicenter, randomized, controlled trial from the SFGM-TC and GFLLC

Author

Sutton, Laurent, Chevret, Sylvie, Tournilhac, Olivier, Diviné, Marine, Leblond, Véronique, Corront, Bernadette, Leprêtre, Stéphane, Eghbali, Houchingue, Van Den Neste, Eric, Michallet, Mauricette, Maloisel, Frédéric, Bouabdallah, Krimo, Decaudin, Didier, Berthou, Christian, Brice, Pauline, Gonzalez, Hugo, Chapiro, Elise, Radford-Weiss, Isabelle, Leporrier, Nathalie, Maloum, Karim, Nguyen-Khac, Florence, Davi, Frédéric, Lejeune, Julie, Merle-Béral, Hélène, and Leporrier, Michel

Published
2011
Full Text
View/download PDF

50. Improvement of Standardization of Molecular Analyses in Hematology: The 10-year GBMHM French Experience

Author

Alary, Anne Sophie, primary, Maute, Carole, additional, Kosmider, Olivier, additional, Sujobert, Pierre, additional, Gauthier, Audrey, additional, Macintyre, Elizabeth, additional, Preudhomme, Claude, additional, Hayette, Sandrine, additional, Luque-Paz, Damien, additional, Baran-Marszak, Fanny, additional, Davi, Frederic, additional, Lippert, Eric, additional, Cornillet-Lefebvre, Pascale, additional, Delfau-Larue, Marie Helene, additional, Cassinat, Bruno, additional, Cayuela, Jean Michel, additional, and Flandrin-Gresta, Pascale, additional

Published
2021
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results