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Petrochemical clusters are forms of industrialization that use compounds and polymers derived directly or indirectly from gas or crude oil for chemical applications. They pose a variety of short- and long-term risks to the environment and the people who live nearby. The aim of this study is to determine whether there is a correlation between the degree of perceived technological risk and the emotional value generated by the contemplation of the petrochemical industry landscape in order to try to establish strategic lines of action to mitigate the perception of risk and improve the emotional well-being of the population. This study uses manipulated pictures and a Public Participation Geographic Information System (PPGIS) survey to assess changes in perception and emotional response in residents in Teheran (Iran). Key findings show an insignificant relationship between technological risk and landscape value perception in both original and manipulated pictures. However, taking into account that, in general, in manipulated pictures, there is a more significant relationship, designing the landscape could help to mitigate the technological risk perception. This study contributes to the broader discussion about industrialization and its environmental and social consequences. It emphasizes the importance of considering public perception when planning and developing industrial areas, so as to balance industrial functionality and environmental and aesthetic considerations for long-term urban development.

Abstract With the exception of a few groups of birds, such as large raptors and colonial seabirds, direct counts of nests cannot be conducted over very large areas for most of the abundant and widely distributed species, and thus indirect methods are used to estimate their relative abundances and population sizes. However, many species of the Family Hirundinidae (swallows and martins) build their mud nests in discrete, predictable and accessible sites, which are reused across years. Therefore, the direct count of active nests could constitute a reliable method for estimating breeding population sizes and their changes at large spatial and temporal scales. We illustrate the feasibility of this monitoring approach through a single year survey of >2700 nests of three coexisting Old‐World species, the barn swallow (Hirundo rustica), the red‐rumped swallow (Cecropis daurica), and the crag martin (Ptyonoprogne rupestris), distributed across Portugal and Spain. Our results revealed changes in the use of nesting substrates and increases in interspecific nest usurpation rates over recent decades. While 56% of the nests of C. daurica were located in rocks five decades ago, almost 100% are nowadays located in anthropogenic substrates such as bridges, road culverts, and abandoned buildings, which could have favored the range expansion of this species. Nest occupation rates were surprisingly low (12% in C. daurica, 21% in H. rustica, and 37% in P. rupestris), and the proportion of abandoned nesting sites was very high (65% in C. daurica, 50% in H. rustica, and 27% in P. rupestris). Abandonment rates reflect the population decline reported for H. rustica. Notably, the usurpation of nests of C. daurica by house sparrows Passer domesticus, which is the main cause of breeding failure, has increased from 2.4% in 1976–1979 to 34.7% of the nests nowadays. The long‐term monitoring of nests may constitute a reliable and affordable method, with the help of citizen science, for assessing changes in breeding population sizes and conservation threats of these and other mud‐nest building hirundines worldwide.

The movement of the human hand offers various degrees of freedom, enabling efficient performance of dynamic tasks and robust interaction with the environment in a compliant and continuous manner. However, the rigid exoskeleton used in hand rehabilitation limits the user’s freedom of movement, complicating their natural interaction with the environment. In this study, we present a soft exo-glove for assistive rehabilitation actuated by Shape Memory Alloys (SMA), controlled by a surface electromyography (sEMG) hand gesture classifier. Thanks to the actuator type, the soft exo-glove enables slow, smooth, and controlled movements when activated and provides complete control transparency when the device is not active. This advantage enhances the comfort and acceptance of the exo-glove by the patient. On the other hand, the classifier, in conjunction with the control algorithm and the soft exo-glove, offers the potential to use the exo-glove in assistive hand rehabilitation therapy. For user-friendly use, an interface has been developed, enabling the acquisition of new sEMG data from new users, retraining of the classifier, and connection with the soft exo-glove for rehabilitation therapy. The main objective of this study is to demonstrate that the proposed wearable soft exo-glove, along with the control algorithm and the employed classifier, constitutes an effective solution for assistive rehabilitation tasks, as demonstrated with healthy subjects. Furthermore, this solution can be easily adapted to the users’ characteristics and requirements.

Abstract The difficulty in predicting fatal outcomes in patients with coronavirus disease 2019 (COVID‐19) impacts the general morbidity and mortality due to severe acute respiratory syndrome‐coronavirus 2 infection, as it wears out the hospital services that care for these patients. Unfortunately, in several of the candidates for prognostic biomarkers proposed, the predictive power is compromised when patients have pre‐existing comorbidities. A cohort of 147 patients hospitalized for severe COVID‐19 was included in a descriptive, observational, single‐center, and prospective study. Patients were recruited during the first COVID‐19 pandemic wave (April–November 2020). Data were collected from the clinical history whereas immunophenotyping by multiparameter flow cytometry analysis allowed us to assess the expression of surface markers on peripheral leucocyte. Patients were grouped according to the outcome in survivors or non‐survivors. The prognostic value of leucocyte, cytokines or HLA‐DR, CD39, and CD73 was calculated. Hypertension and chronic renal failure but not obesity and diabetes were conditions more frequent among the deceased patient group. Mixed hypercytokinemia, including inflammatory (IL‐6) and anti‐inflammatory (IL‐10) cytokines, was more evident in deceased patients. In the deceased patient group, lymphopenia with a higher neutrophil‐lymphocyte ratio (NLR) value was present. HLA‐DR expression and the percentage of CD39+ cells were higher than non‐COVID‐19 patients but remained similar despite the outcome. Receiver operating characteristic analysis and cutoff value of NLR (69.6%, 9.4), percentage NLR (pNLR; 71.1%, 13.6), and IL‐6 (79.7%, 135.2 pg/mL). The expression of HLA‐DR, CD39, and CD73, as many serum cytokines (other than IL‐6) and chemokines levels do not show prognostic potential, were compared to NLR and pNLR values.

To evaluate perceived risk, it is necessary to understand both the type of risk and the residents’ perceptions. With the rise of information on technology and digital platforms, new avenues have emerged for examining citizens’ risk perception in participatory settings. However, the lack of theoretical and methodological approaches in this area calls for further research. The objective of this article is to fill the existing research gap by conducting a scoping review of published literature that examines risk perception related to the petrochemical industry, specifically focusing on digital platforms and the utilization of participatory processes in assessing risk perception within this industry context. The review analyzes the types of questions and responses encountered during participatory processes. The authors selected and studied 10 papers in-depth after applying specific selection criteria. They identified two types of risks—natural and technological—associated with the petrochemical industry, and two types of questions: general questions such as demographics, education, and employment, and specific questions such as risk perception, trust in government and company information, type of risk, or proximity to polluted areas. The paper identifies two question types in participatory processes: general and specific. It emphasizes that the most frequent participation level is consultation, involving seeking public feedback for decision-making. Risk perception is a common topic in participatory processes, highlighting the importance of understanding and addressing public concerns about activities risks. Understanding risk and questions raised during participation is crucial to studying risk perception. This knowledge can improve policies, identify risk mitigation solutions, and identify relevant questions to aid in logical answers.Systematic Review Registration:http://www.prisma-statement.org/?AspxAutoDetectCookieSupport=1

Abstract Variation in offspring sex ratio, particularly in birds, has been frequently studied over the last century, although seldom using long‐term monitoring data. In raptors, the cost of raising males and females is not equal, and several variables have been found to have significant effects on sex ratio, including food availability, parental age, and hatching order. Sex ratio differences between island populations and their mainland counterparts have been poorly documented, despite broad scientific literature on the island syndrome reporting substantial differences in population demography and ecology. Here, we assessed individual and environmental factors potentially affecting the secondary sex ratio of the long‐lived Egyptian vulture Neophron percnopterus. We used data collected from Spanish mainland and island populations over a ca. 30‐year period (1995–2021) to assess the effects of insularity, parental age, breeding phenology, brood size, hatching order, type of breeding unit (pairs vs. trios), and spatial and temporal variability on offspring sex ratio. No sex bias was found at the population level, but two opposite trends were observed between mainland and island populations consistent with the island syndrome. Offspring sex ratio was nonsignificantly female‐biased in mainland Spain (0.47, n = 1112) but significantly male‐biased in the Canary Islands (0.55, n = 499), where a male‐biased mortality among immatures could be compensating for offspring biases and maintaining a paired adult sex ratio. Temporal and spatial variation in food availability might also have some influence on sex ratio, although the difficulties in quantifying them preclude us from determining the magnitude of such influence. This study shows that insularity influences the offspring sex ratio of the Egyptian vulture through several processes that can affect island and mainland populations differentially. Our research contributes to improving our understanding of sex allocation theory by investigating whether sex ratio deviations from parity are possible as a response to changing environments comprised by multiple and complexly interrelated factors.

In their Comment in @CommsEarth, Manuel Morales and colleagues argue that we must act now to protect green agricultural policies in the EU to ensure food security in the future.

Abstract Timing is essential for survival and reproduction of organisms across the tree of life. The core circadian clock gene Clk is involved in the regulation of annual timing events and shows highly conserved sequence homology across vertebrates except for one variable region of poly-glutamine repeats. Clk genotype varies in some species with latitude, seasonal timing and migration. However, findings are inconsistent, difficult to disentangle from environmental responses, and biased towards high latitudes. Here we combine field data with a common-garden experiment to study associations of Clk polymorphism with latitude, migration and annual-cycle timing within the stonechat species complex across its trans-equatorial distribution range. Our dataset includes 950 records from 717 individuals from nine populations with diverse migratory strategies. Gene diversity was lowest in resident African and Canary Island populations and increased with latitude, independently of migration distance. Repeat length and annual-cycle timing was linked in a population-specific way. Specifically, equatorial African stonechats showed delayed timing with longer repeat length for all annual-cycle stages. Our data suggest that at low latitudes with nearly constant photoperiod, Clk genotype might orchestrate a range of consistent, individual chronotypes. In contrast, the influence of Clk on annual-cycle timing at higher latitudes might be mediated by its interactions with genes involved in (circadian) photoperiodic pathways.

This work presents an innovative honeycomb cell geometry design with enhanced in-plane energy absorption under quasi-static lateral loads. Numerical and experimental compression tests results under axial and lateral loads are analyzed. The proposed cell geometry was designed to overcome the limitations posed by standard hexagonal honeycombs, which show relatively low stiffness and energy absorption under loads that have a significant lateral component. To achieve this, the new cell geometry was designed with internal diagonal walls to support the external walls, increasing its stiffness and impact energy absorption in comparison with the hexagonal cell. 3D-printed unit-cell specimens made from ABS thermoplastic material were subjected to experimental quasi-static compression tests, in both lateral and axial directions. Energy absorption was compared to that of the standard hexagonal cell, with the same mass and height. Finite element models were developed and validated using experimental data. Results show that the innovative geometry absorbs approximately 15% more energy under lateral compression, while maintaining the same level of energy absorption of the standard hexagonal cell in the axial direction. The present study demonstrates that the proposed cell geometry has the potential to substitute the standard hexagonal honeycomb in applications where significant lateral loads are present.

Abstract Quantifying space use and segregation, as well as the extrinsic and intrinsic factors affecting them, is crucial to increase our knowledge of species‐specific movement ecology and to design effective management and conservation measures. This is particularly relevant in the case of species that are highly mobile and dependent on sparse and unpredictable trophic resources, such as vultures. Here, we used the GPS‐tagged data of 127 adult Griffon Vultures Gyps fulvus captured at five different breeding regions in Spain to describe the movement patterns (home‐range size and fidelity, and monthly cumulative distance). We also examined how individual sex, season, and breeding region determined the cumulative distance traveled and the size and overlap between consecutive monthly home‐ranges. Overall, Griffon Vultures exhibited very large annual home‐range sizes of 5027 ± 2123 km2, mean monthly cumulative distances of 1776 ± 1497 km, and showed a monthly home‐range fidelity of 67.8 ± 25.5%. However, individuals from northern breeding regions showed smaller home‐ranges and traveled shorter monthly distances than those from southern ones. In all cases, home‐ranges were larger in spring and summer than in winter and autumn, which could be related to difference in flying conditions and food requirements associated with reproduction. Moreover, females showed larger home‐ranges and less monthly fidelity than males, indicating that the latter tended to use the similar areas throughout the year. Overall, our results indicate that both extrinsic and intrinsic factors modulate the home‐range of the Griffon Vulture and that spatial segregation depends on sex and season at the individual level, without relevant differences between breeding regions in individual site fidelity. These results have important implications for conservation, such as identifying key threat factors necessary to improve management actions and policy decisions.

The Dupont’s lark (Chersophilus duponti) is an endangered passerine typical of Mediterranean shrub-steppes, whose European distribution is restricted to Spain. Here, we update the population size and distribution range of the species at a European scale and evaluate (i) the current status; (ii) the change in population size and distribution range of the species from 2004 to 2009 to the current period (2017–2022); and (iii) the effectiveness of the current network of special protection areas (SPAs) for protecting the Dupont’s lark. The European Dupont’s lark population showed a decrease of 29.9%, declining from ca. 3267 to 2289 territorial males from 2004 to 2009 to the current period. Moreover, the species has suffered a contraction in its distribution range of 35.9%, with only 39.3% of the species’ territories located within the current network of SPAs. Our findings agree with the previously described decline of the Dupont’s lark in Europe. The population decline was even larger in peripheral regions, which suggests that the species is suffering a centripetal process of contraction and extinction. These results indicate that if there is no change in present-day declining forces, several peripheral populations will reach extinction in a few decades and the overall population size of the species will continue decreasing. Our study should be considered as a last call for action and used for implementing urgent conservation measures to protect the species and its habitat. Future studies should focus on analyzing and managing the factors driving the species’ extinction and future actions for the conservation of the species should focus on increasing the percentage of the Dupont’s lark territories within protected areas, since the data are alarmingly low for a species that is facing clear risk of extinction.

Abstract Natal dispersal, the movement between the birth and the first breeding site, has been rarely studied in long-lived territorial birds with a long-lasting pre-breeding stage. Here we benefited from the long-term monitoring programs of six populations of Egyptian vultures (Neophron percnopterus) from Spain and France to study how the rearing environment determines dispersal. For 124 vultures, we recorded a median dispersal distance of 48 km (range 0–656 km). Linear models were used to assess the effect of population and individual traits on dispersal distance at two spatial scales. Dispersal distances were inversely related to vulture density in the natal population, suggesting that birds perceive the abundance of conspecifics as a signal of habitat quality. This was particularly true for declining populations, so increasing levels of opportunistic philopatry seemed to arise in high density contexts as a consequence of vacancies created by human-induced adult mortality. Females dispersed further than males, but males were more sensitive to the social environment, indicating different dispersal tactics. Both sexes were affected by different individual attributes simultaneously and interactively with this social context. These results highlight that complex phenotype-by-environment interactions should be considered for advancing our understanding of dispersal dynamics in long-lived organisms.

This paper presents a Public Participation Geographic Information System (PPGIS) application conducted in the Ebro Delta Natural Park, Spain. It aims to support decision-making and management activities. The application is based on an online PPGIS questionnaire using Google Maps API. Participants were asked about the spatial and temporal usage while visiting the Natural Park, about their landscape preferences, and appreciations. A set of eight pairs of bipolar adjectives related to landscape characteristics and experience, four items related to public use, and nine to leisure activities were used. In total, 204 valid answers and 3,969 georeferenced opinions were mapped by this case study. The results of this mapping give insights in the use, perception and appreciation of landscape naturalness and aesthetic beauty, accessibility, facilities, services, and signposting. Furthermore, this study discuss the outcomes of mapping the results and how they support the park management with regard to the identification of conflicts, and the need for action. Finally, this study discuss potentials and limitations of PPGIS as a tool for public participation to capture visitors' experiential knowledge in order to optimize and enhance the management of protected areas.

Abstract: Posttransplant cyclophosphamide (PTCy) effectively prevents graft-versus-host disease (GVHD) after HLA-haploidentical hematopoietic stem cell transplantation (HSCT). The use of PTCy in HLA-identical HSCT is less explored. We conducted a retrospective study of 107 consecutive patients undergoing an HLA-identical sibling (10/10) HSCT in 2 centers in Spain, 50 with GVHD prophylaxis with methotrexate–cyclosporin A (MTX-CsA) and 57 using a PTCy-based regimen with additional immunosuppression. Graft source was unmanipulated mobilized peripheral blood stem cells (PBSC) in most patients (97 patients, 91%). Cumulative incidences of grade II to IV and III to IV acute GVHD at 100 days were lower in the PTCy group (22.6% vs 52.2%, P = .0015; 8.8% vs 24.4%, P = .016), without statistically significant differences in the 2-year cumulative incidence of chronic moderate to severe GVHD (16.7% vs 26%, P = .306). At 2 years, no statistically significant differences were observed in OS (78% vs 56%, P = .088), EFS (62.5% vs 48%, P = .054), relapse (28% vs 27%, P = .47), and NRM (8.8% vs 24%, P = .054). The composite endpoint of GVHD and relapse-free survival (GRFS) was favorable for the PTCy group (24% vs 48%, P = .011), PTCy being the sole independent factor identified in the multivariate analysis for this endpoint. In this study, PTCy combination with additional immunosuppression using mostly PBSCs grafts showed a reduction of acute GVHD rate and an impact on GRFS, with safety results comparable with those obtained with MTX-CsA. Further prospective studies are needed to confirm these observations..

Introducción

Landscape characterisation using social media photographs from popular platforms has been proposed as a landscape and ecosystem services approach. However, popular crowdsourced websites provide uncharacterized data and are only representative of the general public. Photographs from crowdsourced sports platforms, whose users are more homogeneous, could help to characterise landscape more uniformly. In this study we use automated content analysis from photographs on Wikiloc, a crowd-sourced sports platform, to characterize landscape in the Ebro Delta Natural Park, a protected area in Spain. Our approach applies big data procedures and spatial analysis to provide in-depth information regarding what draws visitors’ attention to a landscape and to ascertain their intrasite flow. Our results show that sports users are keen on natural landscapes and pay less attention to rural and degraded landscapes, and that areas closer to paths are more photographed than more distant areas.

A whole-exome capture and next-generation sequencing was applied to an 11 y/o patient with a clinical history of congenital hypotonia, generalized motor and cognitive neurodevelopmental delay, and severe cognitive deficit, and without any identifiable Syndromic pattern, and to her parents, we disclosed a de novo heterozygous pathogenic mutation, c.697_699del p.Phe233del (rs786204835)(ACMG classification PS2, PM1, PM2, PP5), harbored in the PURA gene (MIM*600473) (5q31.3), associated with Autosomal Dominant Mental Retardation 31 (MIM # 616158). We used the significant improvement in the accuracy of protein structure prediction recently implemented in AlphaFold that incorporates novel neural network architectures and training procedures based on the evolutionary, physical, and geometric constraints of protein structures. The wild-type (WT) sequence and the mutated sequence, missing the Phe233, were reconstructed. The predicted local Distance Difference Test (lDDT) for the PURAwt and the PURA–Phe233del showed that the occurrence of the Phe233del affects between 220–320 amino acids. The distortion in the PURA structural conformation in the ~5 Å surrounding area after the p.Phe233del produces a conspicuous disruption of the repeat III, where the DNA and RNA helix unwinding capability occurs. PURA Protein–DNA docking corroborated these results in an in silico analysis that showed a loss of the contact of the PURA–Phe233del III repeat domain model with the DNA. Together, (i) the energetic and stereochemical, (ii) the hydropathic indexes and polarity surfaces, and (iii) the hybrid Quantum Mechanics–Molecular Mechanics (QM–MM) analyses of the PURA molecular models demarcate, at the atomic resolution, the specific surrounding region affected by these mutations and pave the way for future cell-based functional analysis. To the best of our knowledge, this is the first report of a de novo mutation underpinning a PURA syndrome in a Latin American patient and highlights the importance of predicting the molecular effects in protein structure using artificial intelligence algorithms and molecular and atomic resolution stereochemical analyses.

Se presenta Fasti Congressuum, un proyecto digital creado por doctorandos universitarios con el objetivo de difundir congresos y calls for papers relacionados con la Antigüedad. Surgido a raíz de las dificultades de acceso a los mismos por parte de los investigadores, este proyecto se basa en el uso de las humanidades digitales y en el espíritu de trabajo en equipo, aprovechando las ventajas de las redes sociales y contribuyendo a crear una red de difusión internacional. Así, Fasti Congressuum está llegando a una notable cantidad de investigadores mediante la utilización de una web trilingüe dinámica y fácil de consultar, cuyos contenidos son difundidos a través de Facebook, de Twitter y de una newsletter. Estos prometedores resultados, junto con el formato de post (que condensa eficazmente la información imprescindible sobre cada congreso) convierten a Fasti Congressuum en una novedosa herramienta dentro del mundo de la difusión académica de la Antigüedad.

En los últimos tiempos, se ha empezado a prestar una merecida atención a la morfología léxica del español desde perspectivas que ponen el foco en un acercamiento pedagógico y didáctico directamente orientado al aula. En todas las etapas de enseñanza, el potenciamiento de la conciencia morfológica y de la reflexión metalingüística deben ser claves en las que fundamentar el proceso de aprendizaje. A partir de un breve decálogo de citas para la reflexión teórica, en el artículo se proponen diversos tipos de actividades que permitan al alumno centrarse en la reflexión inductiva sobre cómo operan los procesos de formación de palabras en español. El objetivo último es que sea el estudiante el que –a través de actividades formuladas de manera guiada– pueda ir obteniendo conclusiones y generalizaciones, y sea capaz incluso de ir descubriendo cuáles deben ser los límites de su propio aprendizaje morfológico en etapas preuniversitarias de su educación.

El siguiente artículo propone el estudio, a partir de los datos proporcionados por la epigrafía latina de las provincias hispanas, de una de las familias imperiales más importantes del período de la anarquía militar, como es el caso de la domus Licinia Augusta (253-268). Se examinarán, por tanto, las técnicas autorrepresentativas de los emperadores Valeriano, Galieno y sus familiares, Salonina, Valeriano el Joven y Salonino, mediante el análisis estadístico de su corpus epigráfico hispano. De esta manera, se estudiarán los tipos, la procedencia o los títulos imperiales más significativos, además de identificar dos fases cronológicas diferentes y subrayar la importancia de las comunidades en las dedicatorias imperiales de la época.

A georeferenced and tagged dataset of photographs is presented. Over 2000 photographs from the Ebro Delta Natural Park, N-E Spain, have been treated. Raw data come from Wikiloc, a Volunteered Geographic Information source, and have been cleansed and systematized. The photographs have been classified according to their image content. An automatic first analysis was performed using 8-bit software. For uncertain tags, a second supervised analysis was performed. Classification into eight types and thirty-seven subtypes was conducted by considering landscape and social reactions. Data have been treated with the ArcGis 10.2. Geographic Information System. This dataset is useful for understanding ecosystem services by means of users' photographs. Keywords: Volunteered geographic information (VGI), Landscape analysis, Image content, Protected areas, Wikiloc

Abstract: Despite considerable advances in our understanding of the pathophysiology of graft-versus-host disease (GVHD), its prediction remains unresolved and depends mainly on clinical data. The aim of this study is to build a predictive model based on clinical variables and cytokine gene polymorphism for predicting acute GVHD (aGVHD) and chronic GVHD (cGVHD) from the analysis of a large cohort of HLA-identical sibling donor allogeneic stem cell transplant (allo-SCT) patients. A total of 25 SNPs in 12 cytokine genes were evaluated in 509 patients. Data were analyzed using a linear regression model and the least absolute shrinkage and selection operator (LASSO). The statistical model was constructed by randomly selecting 85% of cases (training set), and the predictive ability was confirmed based on the remaining 15% of cases (test set). Models including clinical and genetic variables (CG-M) predicted severe aGVHD significantly better than models including only clinical variables (C-M) or only genetic variables (G-M). For grades 3-4 aGVHD, the correct classification rates (CCR1) were: 100% for CG-M, 88% for G-M, and 50% for C-M. On the other hand, CG-M and G-M predicted extensive cGVHD better than C-M (CCR1: 80% vs. 66.7%, respectively). A risk score was calculated based on LASSO multivariate analyses. It was able to correctly stratify patients who developed grades 3-4 aGVHD (P < .001) and extensive cGVHD (P < .001). The novel predictive models proposed here improve the prediction of severe GVHD after allo-SCT. This approach could facilitate personalized risk-adapted clinical management of patients undergoing allo-SCT.

Este estudio pretende demostrar que la perspectiva curvilínea en la obra de Antonio López es obtenida, exclusivamente, a través de la medición de la realidad. También la arquitectura juega un papel decisivo pues su naturaleza rectilínea evidencia la distorsión de las formas que depende de los condicionantes espaciales que utilice el artista. El resultado es un espacio pictórico que aúna principios geométricos, metodológicos y ópticos.

The aim of this paper is to describe a renewed approach to the ABC landscape assessment method, a procedure that undertakes landscape approach considering abiotic (A), biotic (B) and cultural (C) elements shaping the landscape. This new method is organized in three nested multi-scaled levels defined with high accuracy (1:10,000; 1:20,000; 1:25,000), it combines holistic and parametric approaches and it delineates landscape units from both a typological and chorological point of view. The procedure is based on field work, congruently integrates physical, cultural and perceived landscape components and focuses on the spatial dimension of landscape. Landscape units are hierarchised and classified, leading to a landscape taxonomy. An example is given for Muntanyes d’Ordal, in the Barcelona metropolitan area, with 36 units and 1,019 delineations at Level I, 8 units and 74 delineations at Level II and 14 units at Level III. Overall, 42.5% of Level I delineations are defined by biotic elements and 32.4% by anthropic elements, which shows the peri-urban nature of the area studied. The main interest and originality of the method lies in the fact that the holistic and parametric approaches are integrated using a systematic procedure that can be easily replicated anywhere so that results from different areas can be compared.

A major obstacle to obtaining cost-effective experimental data on the fatigue life of sandwich panels is the prohibitive amount of time and cost required to carry out millions of cycles. On the other hand, vibration techniques applied to sandwich geometries fail to match the stress patterns that are obtained from standard flexural fatigue tests. To overcome such limitations, a vibration-based fatigue technique is proposed, which entails the use of sandwich specimens whose geometries are optimized to reproduce the stress distribution observed during three point bend loading while vibrating at the first resonant frequency. The proposed vibration technique was experimentally validated. The results, compared with the average number of cycles to failure at different stress ratios obtained via the Three-Point Bending test, showed high levels of accuracy. The proposed method is robust and time effective and indicates the possibility of attaining fatigue lifetime prediction of a wide class of composite elements, such as sandwich panels.

Mapping cognitive landscape perception is hindered by the difficulty of representing opinions that are spatially distributed in a heterogeneous way or not restricted by the locations of physical elements in the landscape. In recent years, the use of tools based on geographic information techniques has gained momentum in landscape assessment. We propose a methodology for generalizing cognitive landscape opinions on a spatial basis. To this end, we used a public participatory geographic information system to collect data, which is a method based on bipolar adjectives to approach users’ opinions, and the inverse distance weighted spatial interpolator and multi-criteria evaluation to undertake the spatial analysis. The study was conducted in the Ebro Delta, which is a protected wetland in northeastern Spain. The assessment was based on 1593 georeferenced opinions and resulted in a continuous geographic map of 330 km2 depicting positive and negative perceptions about the landscape. The area under study was perceived as productive, interesting, attractive, and, for the most part, quiet and peaceful, although it was seen as dirty in some parts. The method successfully mapped cognitive landscape opinions and establishes a novel procedure in landscape approaches.

Al present article, s’hi mostra l’interès de la cartografia cognitiva per valorar el coneixement del territori i el raonament espacial. L’estudi es desenvolupa al delta de l’Ebre i s’estructura a partir de consignar topònims i elements d’interès territorial en un mapa mut. La població mostral són 132 estudiants de darrer curs de batxillerat dels cinc centres d’educació secundària del Delta. Mitjançant diferents tècniques d’anàlisi cartogràfica, s’evidencien aspectes de cognició espacial difícils de detectar amb altres procediments. Els resultats assenyalen que els participants tenen un bon coneixement del territori però que presenten dificultats a l’hora de concretar-lo en un mapa a escala detallada, a causa d’unes habilitats espacials poc treballades.

We assembled and annotated the complete mitochondrial genome of Trouessartia rubecula, the first feather mite complete mitochondrial genome from the largest feather mite superfamily Analgoidea (ca. 1150 spp). The mitogenome was composed of 13 protein, 17 tRNA, and 2 rRNA-coding genes and was 14,125 bp in length.

We report a lung-invasive fungal disease with possible cutaneous needle tract seeding in a patient with a febrile neutropenia caused by the Basidiomycetes mold Inonotus spp. Although rare, Inonotus spp. should be added to the list of microorganisms causing invasive fungal disease in neutropenic patients with hematologic malignancies.

Allogenic hematopoietic stem cell transplantation (allo-HSCT) is a curative procedure for several hematological malignancies. Haploidentical HSCT (haplo-HSCT) using high-dose post-transplantation cyclophosphamide (PTCy) makes transplantation possible for patients with no HLA-matched sibling donor. However, this treatment can cause complications, mainly infection, graft-vs.-host disease (GVHD), and conditioning-related toxicity. In recent years, different biomarkers in the form of tissue-specific proteins have been investigated; these may help us to predict complications of allo-HSCT. In this study we explored two such biomarkers, suppression of tumorigenicity 2 (ST2) and regenerating islet-derived 3α (REG3α), in the largest series reported of T cell–replete haplo-HSCT with PTCy. Plasma samples drawn from 87 patients at days +15 and +30 were analyzed. ST2 and REG3α levels at day +15 were not associated with post-transplant complications. ST2 levels at day +30 were higher in patients with grade II-IV acute GVHD, mainly those who received reduced intensity conditioning (RIC; median 2,503 vs. 1,830 ng/ml; p = 0.04). Of note, patients with higher plasma ST2 levels at day +30 also presented a higher incidence of non-relapse mortality (HR, 7.9; p = 0.004) and lower 2-year overall survival (25 vs. 44 months; p = 0.02) than patients with lower levels. Patients with REG3α levels higher than 1,989 pg/ml at day +30 presented a higher incidence of acute gastrointestinal GVHD in the whole cohort (HR, 8.37; p = 0.003) and in the RIC cohort (HR 6.59; p = 0.01). These data suggest that measurement of ST2 and REG3α might be useful for the prognosis and prediction of complications in patients undergoing haplo-HSCT with PTCy.

A menudo, el interés científico por la sal ha encontrado provechosos socios en los investigadores de la economía ro­mana, más que en su relación simbólica con los pobladores. Por ello, el estudio se propone analizar la relación existen­te entre la sal y la religión romana, to­mando para ello el ejemplo del culto de Hércules en Roma, Ostia y el centro de Italia. Con ese fin se analizará en un pri­mer momento la figura del dios itálico en su contexto originario, subrayando sus diferencias conceptuales con el dios grecorromano más tardío y su relación con la sal y su culto urbano. En un se­gundo momento, se revisará el papel que desempeña el dios con la ciudad de Ostia y su casuística, para, en último lugar, es­tudiar la devoción de la divinidad en el centro de Italia, tremendamente radica­da desde tiempos muy remotos en san­tuarios como el de Alba Fucens.